TRMT12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein deneddylation (GO:0000338)4.99130038
2cullin deneddylation (GO:0010388)4.86126837
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.55063760
4ribosomal small subunit assembly (GO:0000028)4.37556308
5ribosomal large subunit biogenesis (GO:0042273)4.37477032
6proteasome assembly (GO:0043248)4.30527668
7DNA replication initiation (GO:0006270)4.11566441
8rRNA modification (GO:0000154)4.11548932
9maturation of 5.8S rRNA (GO:0000460)4.09306306
10pseudouridine synthesis (GO:0001522)4.05534528
11nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.00037887
12viral life cycle (GO:0019058)3.96724165
13establishment of protein localization to endoplasmic reticulum (GO:0072599)3.95203409
14L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.94729827
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.94394755
16DNA deamination (GO:0045006)3.90722326
17termination of RNA polymerase III transcription (GO:0006386)3.87935993
18transcription elongation from RNA polymerase III promoter (GO:0006385)3.87935993
19DNA strand elongation involved in DNA replication (GO:0006271)3.87196183
20protein localization to endoplasmic reticulum (GO:0070972)3.85488712
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.84738383
22DNA strand elongation (GO:0022616)3.84116833
23translational initiation (GO:0006413)3.81404961
24CENP-A containing nucleosome assembly (GO:0034080)3.81088532
25rRNA methylation (GO:0031167)3.78592349
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78422239
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.78422239
28NADH dehydrogenase complex assembly (GO:0010257)3.78422239
29cellular protein complex disassembly (GO:0043624)3.76429626
30maturation of SSU-rRNA (GO:0030490)3.74125846
31respiratory chain complex IV assembly (GO:0008535)3.70149220
32telomere maintenance via semi-conservative replication (GO:0032201)3.69968364
33base-excision repair, AP site formation (GO:0006285)3.68917746
34protein complex biogenesis (GO:0070271)3.66180330
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.64459989
367-methylguanosine mRNA capping (GO:0006370)3.59825211
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.56188908
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.56088863
39chromatin remodeling at centromere (GO:0031055)3.56023600
40telomere maintenance via recombination (GO:0000722)3.55695424
41RNA capping (GO:0036260)3.54689028
427-methylguanosine RNA capping (GO:0009452)3.54689028
43water-soluble vitamin biosynthetic process (GO:0042364)3.53735182
44protoporphyrinogen IX biosynthetic process (GO:0006782)3.52774332
45negative regulation of ligase activity (GO:0051352)3.52106374
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.52106374
47chaperone-mediated protein transport (GO:0072321)3.48665198
48DNA replication checkpoint (GO:0000076)3.48237666
49rRNA metabolic process (GO:0016072)3.45547523
50inner mitochondrial membrane organization (GO:0007007)3.43617732
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43168021
52spliceosomal snRNP assembly (GO:0000387)3.40162534
53protein complex disassembly (GO:0043241)3.38589267
54translation (GO:0006412)3.37357455
55DNA damage response, detection of DNA damage (GO:0042769)3.37349987
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.37256758
57nucleobase biosynthetic process (GO:0046112)3.33879798
58tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30089366
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30089366
60regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.30078009
61regulation of mitotic spindle checkpoint (GO:1903504)3.30078009
62mitochondrial respiratory chain complex assembly (GO:0033108)3.29548448
63macromolecular complex disassembly (GO:0032984)3.27690345
64nuclear-transcribed mRNA catabolic process (GO:0000956)3.27283162
65regulation of cellular amino acid metabolic process (GO:0006521)3.27265447
66protoporphyrinogen IX metabolic process (GO:0046501)3.25506106
67behavioral response to nicotine (GO:0035095)3.23285364
68ribosomal small subunit biogenesis (GO:0042274)3.22017764
69transcription-coupled nucleotide-excision repair (GO:0006283)3.20029993
70establishment of integrated proviral latency (GO:0075713)3.19536143
71viral mRNA export from host cell nucleus (GO:0046784)3.18029247
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17610155
73spliceosomal complex assembly (GO:0000245)3.17288805
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16468316
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15696273
76regulation of translational fidelity (GO:0006450)3.14894609
77mRNA catabolic process (GO:0006402)3.14606605
78replication fork processing (GO:0031297)3.14583243
79pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.13952384
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12578439
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12578439
82IMP biosynthetic process (GO:0006188)3.12288043
83amino acid salvage (GO:0043102)3.10703462
84L-methionine salvage (GO:0071267)3.10703462
85L-methionine biosynthetic process (GO:0071265)3.10703462
86deoxyribonucleotide catabolic process (GO:0009264)3.10423792
87mitotic recombination (GO:0006312)3.10190949
88formation of translation preinitiation complex (GO:0001731)3.10027003
89mitochondrial RNA metabolic process (GO:0000959)3.09375019
90IMP metabolic process (GO:0046040)3.08736480
91positive regulation of ligase activity (GO:0051351)3.08071037
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07966854
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07966854
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07966854
95cytochrome complex assembly (GO:0017004)3.07590397
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.07232048
97electron transport chain (GO:0022900)3.06119692
98somatic hypermutation of immunoglobulin genes (GO:0016446)3.05800820
99somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05800820
100metallo-sulfur cluster assembly (GO:0031163)3.04820045
101iron-sulfur cluster assembly (GO:0016226)3.04820045
102respiratory electron transport chain (GO:0022904)3.04582223
103regulation of mitochondrial translation (GO:0070129)3.03713663
104purine nucleobase biosynthetic process (GO:0009113)3.03274489
1052-deoxyribonucleotide biosynthetic process (GO:0009265)3.03192926
106deoxyribose phosphate biosynthetic process (GO:0046385)3.03192926
107exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03081723
108SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.03032341
109cotranslational protein targeting to membrane (GO:0006613)3.02944343
110tRNA methylation (GO:0030488)2.99700121
111DNA replication-independent nucleosome organization (GO:0034724)2.99280917
112DNA replication-independent nucleosome assembly (GO:0006336)2.99280917
113ribosome biogenesis (GO:0042254)2.99066038
114RNA catabolic process (GO:0006401)2.98256822
115deoxyribose phosphate catabolic process (GO:0046386)2.97971286
116viral transcription (GO:0019083)2.97579891
117energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97568523
118ATP synthesis coupled proton transport (GO:0015986)2.97568523
119deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.97437574
120pyrimidine nucleotide catabolic process (GO:0006244)2.97268077
121translational termination (GO:0006415)2.96319637
122peptidyl-arginine omega-N-methylation (GO:0035247)2.95866752
123RNA methylation (GO:0001510)2.94760758
124protein targeting to ER (GO:0045047)2.94513680
125signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93797163
126signal transduction involved in DNA damage checkpoint (GO:0072422)2.93797163
127* ncRNA processing (GO:0034470)2.93075238
128deoxyribonucleotide biosynthetic process (GO:0009263)2.93000693
129protein targeting to mitochondrion (GO:0006626)2.92661736
130folic acid-containing compound biosynthetic process (GO:0009396)2.92483033
131DNA unwinding involved in DNA replication (GO:0006268)2.92165195
132ribonucleoprotein complex biogenesis (GO:0022613)2.90751142
133cellular component biogenesis (GO:0044085)2.90278595
134translational elongation (GO:0006414)2.90140238
135rRNA processing (GO:0006364)2.90016179
136mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89272421
137regulation of ubiquitin-protein transferase activity (GO:0051438)2.88616665
138* ncRNA metabolic process (GO:0034660)2.86491076
139* tRNA processing (GO:0008033)2.86138379
140* tRNA metabolic process (GO:0006399)2.78905981
141protein targeting to membrane (GO:0006612)2.77695343
142regulation of centriole replication (GO:0046599)2.75718444
143establishment of protein localization to mitochondrion (GO:0072655)2.73179297
144maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.73015980
145protein K6-linked ubiquitination (GO:0085020)2.71899448
146transcription from RNA polymerase III promoter (GO:0006383)2.71204353
147intracellular protein transmembrane import (GO:0044743)2.70690865
148tRNA modification (GO:0006400)2.65175785
149histone arginine methylation (GO:0034969)2.64466767
150DNA-templated transcription, termination (GO:0006353)2.62206120
151tRNA aminoacylation (GO:0043039)2.61036818
152amino acid activation (GO:0043038)2.61036818
153regulation of translational elongation (GO:0006448)2.60219331
154ncRNA catabolic process (GO:0034661)2.57205394
155protein localization to mitochondrion (GO:0070585)2.56525198
156ribosome assembly (GO:0042255)2.55906911
157transcription elongation from RNA polymerase I promoter (GO:0006362)2.55247849

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.80300741
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.54782590
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.17112713
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.91229446
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.84619353
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73166021
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.69765757
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68994196
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.41784850
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.29916036
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.29777494
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21096393
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83468956
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76814840
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71799512
16* VDR_23849224_ChIP-Seq_CD4+_Human2.63608567
17* SRF_21415370_ChIP-Seq_HL-1_Mouse2.51185424
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48439336
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48385980
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48234185
21FOXP3_21729870_ChIP-Seq_TREG_Human2.46041668
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41976034
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.38744054
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34823357
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.34029541
26DCP1A_22483619_ChIP-Seq_HELA_Human2.32279897
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32072742
28XRN2_22483619_ChIP-Seq_HELA_Human2.29591859
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24643693
30GABP_19822575_ChIP-Seq_HepG2_Human2.24526986
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.22504977
32* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19127189
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17153958
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16120666
35* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.12958653
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04741937
37* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03270121
38* ELK1_19687146_ChIP-ChIP_HELA_Human1.92709726
39ZNF274_21170338_ChIP-Seq_K562_Hela1.89384647
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87366655
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85909929
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84866364
43* TTF2_22483619_ChIP-Seq_HELA_Human1.79668005
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.76000853
45* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71411344
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.71071316
47* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70271797
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.69288792
49GATA1_22025678_ChIP-Seq_K562_Human1.68054097
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67754758
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.67121285
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65029353
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61033909
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60955131
55AR_21909140_ChIP-Seq_LNCAP_Human1.56387167
56* CIITA_25753668_ChIP-Seq_RAJI_Human1.54811849
57* YY1_21170310_ChIP-Seq_MESCs_Mouse1.51324274
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50152354
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47179452
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46312719
61* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42901749
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39190656
63ELF5_23300383_ChIP-Seq_T47D_Human1.37891872
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37815292
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34819948
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.32242117
67KDM5A_27292631_Chip-Seq_BREAST_Human1.28641412
68* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28631307
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27806837
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25872664
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25447279
72* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23547767
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.23099009
74MYC_18940864_ChIP-ChIP_HL60_Human1.22685698
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21564235
76EWS_26573619_Chip-Seq_HEK293_Human1.19528339
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18981284
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15849388
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14564604
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.14021059
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12961026
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12715628
83SPI1_23547873_ChIP-Seq_NB4_Human1.11110774
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10253468
85TFEB_21752829_ChIP-Seq_HELA_Human1.10119811
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09804341
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09536200
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06340185
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.05695172
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01251725
91* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98732227
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98343920
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98208131
94* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98014471
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93603418
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93591385
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92996929
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91966989
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90022259
100NANOG_16153702_ChIP-ChIP_HESCs_Human0.89614743
101POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89302543
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89028760
103VDR_22108803_ChIP-Seq_LS180_Human0.86667341
104* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86073946
105FUS_26573619_Chip-Seq_HEK293_Human0.86067275
106FOXP1_21924763_ChIP-Seq_HESCs_Human0.85976861
107KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85533051
108* ER_23166858_ChIP-Seq_MCF-7_Human0.85488920
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82822447
110MYC_22102868_ChIP-Seq_BL_Human0.82768579
111* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82149786
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82098013
113KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78956751
114TP53_22573176_ChIP-Seq_HFKS_Human0.77969085
115CHD1_26751641_Chip-Seq_LNCaP_Human0.76882629
116KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.75669742
117CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75058475
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73039182
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.72127119
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.71727866
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70866073
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69529582
123PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.66886523
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.65166576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.14564201
2MP0008057_abnormal_DNA_replication3.85058129
3MP0000569_abnormal_digit_pigmentation3.68463423
4MP0010094_abnormal_chromosome_stability3.58791990
5MP0004957_abnormal_blastocyst_morpholog3.48738446
6MP0003111_abnormal_nucleus_morphology3.02148185
7MP0004147_increased_porphyrin_level2.91609691
8MP0003077_abnormal_cell_cycle2.88240315
9MP0003123_paternal_imprinting2.77904463
10MP0008058_abnormal_DNA_repair2.67436750
11MP0003656_abnormal_erythrocyte_physiolo2.66674283
12MP0001529_abnormal_vocalization2.59538779
13MP0008877_abnormal_DNA_methylation2.53342450
14MP0001873_stomach_inflammation2.39505921
15MP0002234_abnormal_pharynx_morphology2.30954075
16MP0006036_abnormal_mitochondrial_physio2.15058784
17MP0001905_abnormal_dopamine_level2.13494032
18MP0001986_abnormal_taste_sensitivity2.05937705
19MP0001293_anophthalmia2.04047476
20MP0005075_abnormal_melanosome_morpholog2.00478958
21MP0008932_abnormal_embryonic_tissue1.97092766
22MP0003121_genomic_imprinting1.81800742
23MP0008995_early_reproductive_senescence1.80403338
24MP0002396_abnormal_hematopoietic_system1.75934991
25MP0006072_abnormal_retinal_apoptosis1.71520680
26MP0006292_abnormal_olfactory_placode1.70372195
27MP0005671_abnormal_response_to1.65388248
28MP0003315_abnormal_perineum_morphology1.62990914
29MP0002398_abnormal_bone_marrow1.61973077
30MP0008789_abnormal_olfactory_epithelium1.56473559
31MP0006054_spinal_hemorrhage1.55820624
32MP0004808_abnormal_hematopoietic_stem1.54402013
33MP0000689_abnormal_spleen_morphology1.54073172
34MP0008007_abnormal_cellular_replicative1.53908411
35MP0009333_abnormal_splenocyte_physiolog1.49625660
36MP0003011_delayed_dark_adaptation1.46567479
37MP0003718_maternal_effect1.45473295
38MP0009697_abnormal_copulation1.45151177
39MP0003763_abnormal_thymus_physiology1.43834502
40MP0005423_abnormal_somatic_nervous1.43802462
41MP0005084_abnormal_gallbladder_morpholo1.42118672
42MP0001730_embryonic_growth_arrest1.42048845
43MP0005645_abnormal_hypothalamus_physiol1.41997649
44MP0003122_maternal_imprinting1.41891452
45MP0005646_abnormal_pituitary_gland1.40649405
46MP0002722_abnormal_immune_system1.40263196
47MP0003941_abnormal_skin_development1.38322158
48MP0000427_abnormal_hair_cycle1.38105245
49MP0003567_abnormal_fetal_cardiomyocyte1.35791103
50MP0004142_abnormal_muscle_tone1.34577282
51MP0009053_abnormal_anal_canal1.34563748
52MP0000015_abnormal_ear_pigmentation1.34383950
53MP0003890_abnormal_embryonic-extraembry1.34127673
54MP0002132_abnormal_respiratory_system1.33553093
55MP0001835_abnormal_antigen_presentation1.30454095
56MP0001800_abnormal_humoral_immune1.30222912
57MP0000490_abnormal_crypts_of1.30074683
58MP0004233_abnormal_muscle_weight1.28835488
59MP0001188_hyperpigmentation1.28582639
60MP0002837_dystrophic_cardiac_calcinosis1.28519144
61MP0004742_abnormal_vestibular_system1.28161010
62MP0002019_abnormal_tumor_incidence1.27388865
63MP0002095_abnormal_skin_pigmentation1.25478977
64MP0002277_abnormal_respiratory_mucosa1.25265252
65MP0003937_abnormal_limbs/digits/tail_de1.22883169
66MP0000703_abnormal_thymus_morphology1.22528023
67MP0000631_abnormal_neuroendocrine_gland1.22180152
68MP0005220_abnormal_exocrine_pancreas1.20879815
69MP0003880_abnormal_central_pattern1.20100428
70MP0002429_abnormal_blood_cell1.18517701
71MP0006035_abnormal_mitochondrial_morpho1.18503369
72MP0003786_premature_aging1.18497719
73MP0008260_abnormal_autophagy1.15196473
74MP0002751_abnormal_autonomic_nervous1.14471920
75MP0002160_abnormal_reproductive_system1.14094516
76MP0003186_abnormal_redox_activity1.13555985
77MP0000749_muscle_degeneration1.13025401
78MP0003806_abnormal_nucleotide_metabolis1.11109104
79MP0001545_abnormal_hematopoietic_system1.10906733
80MP0005397_hematopoietic_system_phenotyp1.10906733
81MP0003787_abnormal_imprinting1.10403854
82MP0000716_abnormal_immune_system1.10001315
83MP0004133_heterotaxia1.09156647
84MP0005408_hypopigmentation1.08289778
85MP0000358_abnormal_cell_content/1.07802282
86MP0002102_abnormal_ear_morphology1.07779103
87MP0000049_abnormal_middle_ear1.05346590
88MP0000750_abnormal_muscle_regeneration1.04455891
89MP0002420_abnormal_adaptive_immunity1.04366440
90MP0009379_abnormal_foot_pigmentation1.03690824
91MP0000350_abnormal_cell_proliferation1.02708131
92MP0000681_abnormal_thyroid_gland1.00951903
93MP0001819_abnormal_immune_cell1.00649363
94MP0001984_abnormal_olfaction1.00153759
95MP0001764_abnormal_homeostasis0.99947245
96MP0005174_abnormal_tail_pigmentation0.99756513
97MP0005389_reproductive_system_phenotype0.99402600
98MP0001727_abnormal_embryo_implantation0.99399496
99MP0003646_muscle_fatigue0.99280723
100MP0001697_abnormal_embryo_size0.99228941
101MP0005394_taste/olfaction_phenotype0.98850544
102MP0005499_abnormal_olfactory_system0.98850544
103MP0001485_abnormal_pinna_reflex0.98267226
104MP0000685_abnormal_immune_system0.94986638
105MP0002080_prenatal_lethality0.94944815
106MP0001968_abnormal_touch/_nociception0.94920483
107MP0002723_abnormal_immune_serum0.93774420
108MP0006276_abnormal_autonomic_nervous0.93391739
109MP0002184_abnormal_innervation0.93262017
110MP0000313_abnormal_cell_death0.92998513
111MP0005187_abnormal_penis_morphology0.92311331
112MP0004215_abnormal_myocardial_fiber0.90440094
113MP0002452_abnormal_antigen_presenting0.90201842
114MP0000647_abnormal_sebaceous_gland0.89314078
115MP0001929_abnormal_gametogenesis0.88208365
116MP0002210_abnormal_sex_determination0.87644718
117MP0005310_abnormal_salivary_gland0.85539908
118MP0002084_abnormal_developmental_patter0.85139501
119MP0002697_abnormal_eye_size0.84079083
120MP0001286_abnormal_eye_development0.83844608
121MP0002085_abnormal_embryonic_tissue0.82892203
122MP0003866_abnormal_defecation0.82395192
123MP0000653_abnormal_sex_gland0.82132696
124MP0005636_abnormal_mineral_homeostasis0.81982043
125MP0001672_abnormal_embryogenesis/_devel0.81903067
126MP0005380_embryogenesis_phenotype0.81903067
127MP0002088_abnormal_embryonic_growth/wei0.81135202
128MP0002177_abnormal_outer_ear0.80778759
129MP0002693_abnormal_pancreas_physiology0.80252169
130MP0005501_abnormal_skin_physiology0.80212197
131MP0003172_abnormal_lysosome_physiology0.79422249
132MP0005266_abnormal_metabolism0.78886430
133MP0005384_cellular_phenotype0.77900769
134MP0001145_abnormal_male_reproductive0.74011367
135MP0002796_impaired_skin_barrier0.73729098
136MP0003984_embryonic_growth_retardation0.73725442
137MP0002736_abnormal_nociception_after0.73684158
138MP0001186_pigmentation_phenotype0.72127063
139MP0003879_abnormal_hair_cell0.71992858
140MP0005379_endocrine/exocrine_gland_phen0.71067530
141MP0002909_abnormal_adrenal_gland0.70570241
142MP0003938_abnormal_ear_development0.69848086
143MP0001324_abnormal_eye_pigmentation0.68294762
144MP0004197_abnormal_fetal_growth/weight/0.67920571
145MP0003936_abnormal_reproductive_system0.67889110
146MP0003698_abnormal_male_reproductive0.66900376
147MP0001853_heart_inflammation0.66280165
148MP0001919_abnormal_reproductive_system0.66036853
149MP0000537_abnormal_urethra_morphology0.65652032
150MP0009046_muscle_twitch0.64383286
151MP0001119_abnormal_female_reproductive0.64294013
152MP0002734_abnormal_mechanical_nocicepti0.63691285
153MP0000372_irregular_coat_pigmentation0.63435601
154MP0000465_gastrointestinal_hemorrhage0.62979383
155MP0005464_abnormal_platelet_physiology0.62401771
156MP0002163_abnormal_gland_morphology0.61923210

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.48196224
2Mitochondrial inheritance (HP:0001427)4.42188045
3Hepatocellular necrosis (HP:0001404)4.39942925
4Acute necrotizing encephalopathy (HP:0006965)4.14850590
5Abnormality of the heme biosynthetic pathway (HP:0010472)4.14548046
6Abnormal mitochondria in muscle tissue (HP:0008316)4.08715766
7Increased CSF lactate (HP:0002490)4.03587909
8Increased hepatocellular lipid droplets (HP:0006565)4.00565403
9Hepatic necrosis (HP:0002605)3.66062543
10Lipid accumulation in hepatocytes (HP:0006561)3.65328645
11Progressive macrocephaly (HP:0004481)3.33069398
12Aplastic anemia (HP:0001915)3.32336023
13Concave nail (HP:0001598)3.31431453
14Respiratory difficulties (HP:0002880)3.28769432
15Acute encephalopathy (HP:0006846)3.28464694
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.27261318
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.27261318
18Breast hypoplasia (HP:0003187)3.26996888
19Increased serum lactate (HP:0002151)3.26868626
20Exertional dyspnea (HP:0002875)3.24615793
21Increased intramyocellular lipid droplets (HP:0012240)3.24320014
22Abnormal number of erythroid precursors (HP:0012131)3.22330664
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.18056259
24Renal Fanconi syndrome (HP:0001994)3.17644247
25Abnormality of cells of the erythroid lineage (HP:0012130)3.12167017
26Cerebral hypomyelination (HP:0006808)3.05667408
27Lactic acidosis (HP:0003128)3.05124280
28Abnormal hair whorl (HP:0010721)2.97010739
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.95633594
303-Methylglutaconic aciduria (HP:0003535)2.93368101
31Exercise intolerance (HP:0003546)2.83103960
32Microvesicular hepatic steatosis (HP:0001414)2.82478783
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.77362987
34Degeneration of the lateral corticospinal tracts (HP:0002314)2.77362987
35IgM deficiency (HP:0002850)2.75396488
36Increased serum pyruvate (HP:0003542)2.72247533
37Abnormality of glycolysis (HP:0004366)2.72247533
38Increased muscle lipid content (HP:0009058)2.71397750
39Poor suck (HP:0002033)2.65171474
40Type 2 muscle fiber atrophy (HP:0003554)2.64441431
41Tongue fasciculations (HP:0001308)2.63680259
42Respiratory failure (HP:0002878)2.60940245
43Thrombocytosis (HP:0001894)2.50002170
44Neuroendocrine neoplasm (HP:0100634)2.48145028
45Muscle fiber atrophy (HP:0100295)2.48037408
46CNS hypomyelination (HP:0003429)2.47880975
47Microretrognathia (HP:0000308)2.47861830
48Congenital primary aphakia (HP:0007707)2.43812000
49Degeneration of anterior horn cells (HP:0002398)2.40035613
50Abnormality of the anterior horn cell (HP:0006802)2.40035613
51Nephrogenic diabetes insipidus (HP:0009806)2.38204825
52Gait imbalance (HP:0002141)2.38072929
53Type I transferrin isoform profile (HP:0003642)2.35399061
54Hyperalaninemia (HP:0003348)2.33192641
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33192641
56Abnormality of alanine metabolism (HP:0010916)2.33192641
57Oral leukoplakia (HP:0002745)2.32835875
58Chronic hepatic failure (HP:0100626)2.32434509
59Abnormality of midbrain morphology (HP:0002418)2.32075314
60Molar tooth sign on MRI (HP:0002419)2.32075314
61Medial flaring of the eyebrow (HP:0010747)2.30234682
62Progressive inability to walk (HP:0002505)2.30099289
63Hypothermia (HP:0002045)2.28755819
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28620979
65Type II lissencephaly (HP:0007260)2.26414761
66Colon cancer (HP:0003003)2.25683804
67Chromsome breakage (HP:0040012)2.25220716
68Macrocytic anemia (HP:0001972)2.25197299
69Limb hypertonia (HP:0002509)2.23191532
70Emotional lability (HP:0000712)2.22982393
71Patellar aplasia (HP:0006443)2.22681832
72Abnormality of chromosome stability (HP:0003220)2.21895802
73Missing ribs (HP:0000921)2.20255324
74Pancreatic fibrosis (HP:0100732)2.18719953
75Abnormality of the ileum (HP:0001549)2.18107515
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.14726758
77Cerebral edema (HP:0002181)2.14654210
78IgG deficiency (HP:0004315)2.14222552
79Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13957207
80Muscle fibrillation (HP:0010546)2.12685787
81Gastrointestinal stroma tumor (HP:0100723)2.11590992
82Acute lymphatic leukemia (HP:0006721)2.10641683
83Abnormal protein glycosylation (HP:0012346)2.09589510
84Abnormal glycosylation (HP:0012345)2.09589510
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09589510
86Abnormal protein N-linked glycosylation (HP:0012347)2.09589510
87Abnormality of B cell number (HP:0010975)2.09198178
88B lymphocytopenia (HP:0010976)2.09198178
89Meckel diverticulum (HP:0002245)2.08705582
90Brushfield spots (HP:0001088)2.08275710
91Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07702238
92Retinal dysplasia (HP:0007973)2.07353341
93Abnormality of the preputium (HP:0100587)2.06254265
94Rough bone trabeculation (HP:0100670)2.05253094
95Protruding tongue (HP:0010808)2.01617125
96Delusions (HP:0000746)2.00638927
97Petechiae (HP:0000967)1.99468699
98Unsteady gait (HP:0002317)1.99214542
99Intestinal atresia (HP:0011100)1.98985471
100Inability to walk (HP:0002540)1.97903545
101Carpal bone hypoplasia (HP:0001498)1.97666602
102Pheochromocytoma (HP:0002666)1.97341569
103Postnatal microcephaly (HP:0005484)1.97105819
104Abnormality of DNA repair (HP:0003254)1.96974460
105Optic disc pallor (HP:0000543)1.96471879
106Short thumb (HP:0009778)1.96145584
107Visual hallucinations (HP:0002367)1.95586009
108Cholecystitis (HP:0001082)1.95246280
109Abnormal gallbladder physiology (HP:0012438)1.95246280
110Premature graying of hair (HP:0002216)1.94850993
111Aplasia/Hypoplasia of the patella (HP:0006498)1.94678008
112Abnormality of the corticospinal tract (HP:0002492)1.94584851
113Congenital, generalized hypertrichosis (HP:0004540)1.94220479
114Pallor (HP:0000980)1.91595915
115Irregular epiphyses (HP:0010582)1.90406968
116Pancreatic cysts (HP:0001737)1.90017065
117Pancytopenia (HP:0001876)1.89853343
118CNS demyelination (HP:0007305)1.89804585
119Absent thumb (HP:0009777)1.89302935
120Sparse lateral eyebrow (HP:0005338)1.88709168
121Leukodystrophy (HP:0002415)1.88595586
12211 pairs of ribs (HP:0000878)1.88349499
123Severe visual impairment (HP:0001141)1.88163254
124Abnormality of the pons (HP:0007361)1.87045749
125Cleft eyelid (HP:0000625)1.85218936
126Premature ovarian failure (HP:0008209)1.84306035
127Multiple enchondromatosis (HP:0005701)1.83876110
128Poor coordination (HP:0002370)1.83871024
129Basal cell carcinoma (HP:0002671)1.83857059
130Hypoplasia of the pons (HP:0012110)1.82977328
131Hyperglycinemia (HP:0002154)1.82292720
132Reticulocytopenia (HP:0001896)1.82143059
133Abnormality of renal resorption (HP:0011038)1.81901583
134Depressed nasal tip (HP:0000437)1.81770168
135Secondary amenorrhea (HP:0000869)1.80812866
136Abnormal pupillary function (HP:0007686)1.80000146
137Progressive muscle weakness (HP:0003323)1.78597125
138True hermaphroditism (HP:0010459)1.77235799
139Female pseudohermaphroditism (HP:0010458)1.74443564
140Progressive neurologic deterioration (HP:0002344)1.74083481
141Myelodysplasia (HP:0002863)1.74012186
142Abnormality of the neuromuscular junction (HP:0003398)1.69861421
143Fatigable weakness (HP:0003473)1.69861421
144Abnormality of serum amino acid levels (HP:0003112)1.69643242
145Ragged-red muscle fibers (HP:0003200)1.68943667
146Lethargy (HP:0001254)1.68828970
147Nephronophthisis (HP:0000090)1.63613626
148Oculomotor apraxia (HP:0000657)1.62306109
149Hypoplasia of the radius (HP:0002984)1.61744879
150Triphalangeal thumb (HP:0001199)1.61732753
151Small intestinal stenosis (HP:0012848)1.61395144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.71736770
2MAP3K123.64816768
3MUSK2.99224966
4STK162.98841373
5CDC72.95239427
6INSRR2.80957027
7SCYL22.72408178
8EIF2AK12.66428389
9CDK192.52280040
10WEE12.48878027
11SRPK12.42235523
12CASK2.41964857
13DYRK32.36045509
14TLK12.32636351
15TRIM282.14296473
16VRK22.11117797
17BRSK22.03889786
18NME12.02537656
19VRK11.94979023
20CDK81.94159045
21TIE11.86307122
22CCNB11.75035052
23ZAK1.68250270
24EIF2AK31.67900018
25ACVR1B1.60592027
26DAPK11.59443829
27TAOK31.59407736
28TAF11.55466760
29MAP4K11.50143436
30TSSK61.48566480
31NME21.44676134
32TESK21.42723279
33PLK41.40847724
34MAPKAPK31.40724618
35MAP2K71.37982911
36TEC1.37605871
37RPS6KB21.36497671
38PIM21.34584463
39FLT31.33816134
40ARAF1.27337480
41BLK1.27072454
42IRAK31.24585899
43ZAP701.22824658
44PLK11.19496963
45RPS6KA51.18979944
46BRD41.17034230
47SYK1.16884648
48PIK3CA1.16173902
49AURKA1.16168764
50MAP4K21.12728218
51CSNK1G31.12184759
52KIT1.10830506
53BMPR1B1.08742959
54GRK11.08550385
55CAMK1D1.07004878
56MYLK1.06321827
57BRAF1.05151345
58GRK61.01858663
59NUAK11.01749500
60ADRBK21.00824369
61CHEK21.00507685
62CDK120.99798165
63AURKB0.98990963
64BRSK10.96744414
65PBK0.96071519
66MKNK10.94014099
67PLK30.93968600
68PASK0.88714578
69NEK20.87737708
70TGFBR10.83876104
71NEK10.80881310
72MAP2K40.79650898
73RPS6KA40.78102711
74MAP3K40.77045739
75ATR0.76673192
76PAK40.76536139
77CLK10.76148251
78MAPK130.75522173
79BTK0.74284094
80MAP2K20.74144828
81MKNK20.74006175
82ERBB30.72470759
83MAP3K110.71772573
84CSF1R0.71552107
85MST40.70805571
86TTK0.68408259
87PLK20.68359748
88CAMKK20.67787232
89MAP3K90.67558877
90LYN0.67041510
91CSNK1G10.66813745
92BCKDK0.66752867
93RAF10.66163289
94CHEK10.63796278
95MAPKAPK50.63641364
96PIK3CG0.61952759
97ALK0.61651357
98CDK70.60927744
99KDR0.60410149
100PNCK0.59104812
101BMPR20.59039636
102DYRK20.57668618
103MAPK150.54021944
104KSR10.53457023
105ERBB40.52993476
106CSNK1G20.51949506
107TRIB30.51430670
108CDK30.51030951
109EEF2K0.50151356
110CDK40.49382241
111TYK20.48273670
112CSNK2A10.48243944
113OBSCN0.46488415
114CSNK2A20.46401711
115STK38L0.45818210
116PRKCI0.45432678
117AKT30.45121896
118ATM0.44894651
119CDK10.42071365
120TXK0.41847716
121LRRK20.41351797
122DAPK30.39860799
123PRKCG0.39019199
124CDK20.38228531
125CHUK0.38041312
126CSNK1E0.36892812
127MAP3K60.36615179
128TNIK0.36319907
129CDK180.35441162
130RPS6KB10.34301902
131YES10.33421841
132CDK140.33363333
133CDK11A0.32945403
134OXSR10.32894979
135MATK0.32157360
136CDK150.31333861
137ITK0.29018643
138MAP3K80.28915522
139PAK10.28296172
140PIM10.28141703
141STK240.28075913
142SIK30.27802275

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.15094423
2DNA replication_Homo sapiens_hsa030304.01825339
3RNA polymerase_Homo sapiens_hsa030203.98337473
4Mismatch repair_Homo sapiens_hsa034303.45316218
5Ribosome_Homo sapiens_hsa030103.32430356
6Oxidative phosphorylation_Homo sapiens_hsa001902.77973747
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71210895
8Pyrimidine metabolism_Homo sapiens_hsa002402.63786499
9Protein export_Homo sapiens_hsa030602.63528972
10Homologous recombination_Homo sapiens_hsa034402.51406715
11Base excision repair_Homo sapiens_hsa034102.49790714
12Parkinsons disease_Homo sapiens_hsa050122.45486345
13Spliceosome_Homo sapiens_hsa030402.41945000
14Nucleotide excision repair_Homo sapiens_hsa034202.38570721
15RNA transport_Homo sapiens_hsa030132.08457508
16Non-homologous end-joining_Homo sapiens_hsa034502.05745486
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03936727
18Cell cycle_Homo sapiens_hsa041102.00128516
19Basal transcription factors_Homo sapiens_hsa030221.94990852
20Huntingtons disease_Homo sapiens_hsa050161.81352318
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76906403
22Folate biosynthesis_Homo sapiens_hsa007901.72868236
23Purine metabolism_Homo sapiens_hsa002301.68647249
24Alzheimers disease_Homo sapiens_hsa050101.67418868
25RNA degradation_Homo sapiens_hsa030181.61002093
26Collecting duct acid secretion_Homo sapiens_hsa049661.49537157
27Fanconi anemia pathway_Homo sapiens_hsa034601.47817770
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42698152
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40209660
30One carbon pool by folate_Homo sapiens_hsa006701.40149895
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31692210
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25415459
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.24789104
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20937301
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17882631
36Vitamin B6 metabolism_Homo sapiens_hsa007501.12198170
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10692004
38Epstein-Barr virus infection_Homo sapiens_hsa051691.05970733
39Pyruvate metabolism_Homo sapiens_hsa006201.03227553
40Pentose phosphate pathway_Homo sapiens_hsa000301.02385845
41Vibrio cholerae infection_Homo sapiens_hsa051100.99587471
42Biosynthesis of amino acids_Homo sapiens_hsa012300.93251853
43Systemic lupus erythematosus_Homo sapiens_hsa053220.92620251
44N-Glycan biosynthesis_Homo sapiens_hsa005100.92432094
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90196328
46Synaptic vesicle cycle_Homo sapiens_hsa047210.84855552
47Primary immunodeficiency_Homo sapiens_hsa053400.81066694
48Oocyte meiosis_Homo sapiens_hsa041140.80281082
49Butanoate metabolism_Homo sapiens_hsa006500.78912372
50Melanoma_Homo sapiens_hsa052180.78640389
51p53 signaling pathway_Homo sapiens_hsa041150.76494167
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76306615
53Alcoholism_Homo sapiens_hsa050340.75990785
54Metabolic pathways_Homo sapiens_hsa011000.70529431
55Steroid biosynthesis_Homo sapiens_hsa001000.68776406
56Carbon metabolism_Homo sapiens_hsa012000.67536838
57Peroxisome_Homo sapiens_hsa041460.64234903
58Regulation of autophagy_Homo sapiens_hsa041400.63749038
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63189450
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.61938304
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59418569
62Cardiac muscle contraction_Homo sapiens_hsa042600.57863897
63mRNA surveillance pathway_Homo sapiens_hsa030150.56884408
64Propanoate metabolism_Homo sapiens_hsa006400.56283892
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55984060
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.51722278
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50992214
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48364141
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48150653
70Phototransduction_Homo sapiens_hsa047440.48123136
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48112335
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46275938
73Antigen processing and presentation_Homo sapiens_hsa046120.44955352
74Viral carcinogenesis_Homo sapiens_hsa052030.44226940
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43233278
76Other glycan degradation_Homo sapiens_hsa005110.41697887
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41307677
78Nicotine addiction_Homo sapiens_hsa050330.41142896
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39943718
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39370448
81Fructose and mannose metabolism_Homo sapiens_hsa000510.39092184
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.38422297
83Glutathione metabolism_Homo sapiens_hsa004800.36909018
84Herpes simplex infection_Homo sapiens_hsa051680.36110083
85Renal cell carcinoma_Homo sapiens_hsa052110.35269047
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.35015492
87Linoleic acid metabolism_Homo sapiens_hsa005910.33211026
88Galactose metabolism_Homo sapiens_hsa000520.33070360
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33064540
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32341372
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31503224
92Apoptosis_Homo sapiens_hsa042100.29288365
93Fatty acid elongation_Homo sapiens_hsa000620.28996045
94Phagosome_Homo sapiens_hsa041450.28279447
95Sulfur metabolism_Homo sapiens_hsa009200.28252791
96Selenocompound metabolism_Homo sapiens_hsa004500.27618623
97Bladder cancer_Homo sapiens_hsa052190.27208688
98Basal cell carcinoma_Homo sapiens_hsa052170.26857320
99Thyroid cancer_Homo sapiens_hsa052160.26322132
100ErbB signaling pathway_Homo sapiens_hsa040120.26129923
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25331072
102Prolactin signaling pathway_Homo sapiens_hsa049170.24641318
103Caffeine metabolism_Homo sapiens_hsa002320.24499044
104Colorectal cancer_Homo sapiens_hsa052100.24415759
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.21200091
106Acute myeloid leukemia_Homo sapiens_hsa052210.20815382
107Endometrial cancer_Homo sapiens_hsa052130.19918808
108Lysosome_Homo sapiens_hsa041420.19510608
109Vitamin digestion and absorption_Homo sapiens_hsa049770.18606973
110Hematopoietic cell lineage_Homo sapiens_hsa046400.18209824
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18167392
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.16763510
113B cell receptor signaling pathway_Homo sapiens_hsa046620.16355404
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15692909
115T cell receptor signaling pathway_Homo sapiens_hsa046600.15284014
116Hippo signaling pathway_Homo sapiens_hsa043900.13357437
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13164155
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12461762
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12034676
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11283650
121Type II diabetes mellitus_Homo sapiens_hsa049300.10822288
122Hedgehog signaling pathway_Homo sapiens_hsa043400.10242313
123Hepatitis B_Homo sapiens_hsa051610.09684250
124Olfactory transduction_Homo sapiens_hsa047400.09673733
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.09334957
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.09080192
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.08657335
128Sphingolipid metabolism_Homo sapiens_hsa006000.08649315
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.08041627
130Shigellosis_Homo sapiens_hsa051310.07954669
131HTLV-I infection_Homo sapiens_hsa051660.07919272
132Tyrosine metabolism_Homo sapiens_hsa003500.07757033
133Dopaminergic synapse_Homo sapiens_hsa047280.07674786
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.07443341
135Arachidonic acid metabolism_Homo sapiens_hsa005900.07289354
136Sulfur relay system_Homo sapiens_hsa041220.07055958
137Arginine and proline metabolism_Homo sapiens_hsa003300.05114843
138Rheumatoid arthritis_Homo sapiens_hsa053230.04905154
139Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.04448848
140Legionellosis_Homo sapiens_hsa051340.01477815

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