TRMT1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)7.62974290
2chromosome organization involved in meiosis (GO:0070192)6.51099985
3DNA synthesis involved in DNA repair (GO:0000731)6.04242270
4synaptonemal complex assembly (GO:0007130)5.76435157
5nuclear pore complex assembly (GO:0051292)5.66743290
6male meiosis I (GO:0007141)5.24087010
7synaptonemal complex organization (GO:0070193)5.17283503
8nuclear pore organization (GO:0006999)4.95117349
9piRNA metabolic process (GO:0034587)4.73866999
10male meiosis (GO:0007140)4.67638505
11meiotic nuclear division (GO:0007126)4.59083505
12sister chromatid cohesion (GO:0007062)4.31488035
13meiosis I (GO:0007127)4.27851482
14resolution of meiotic recombination intermediates (GO:0000712)4.24817278
15positive regulation of cellular amide metabolic process (GO:0034250)4.17676637
16mitotic sister chromatid cohesion (GO:0007064)4.16812382
17meiotic cell cycle process (GO:1903046)4.14471061
18DNA methylation involved in gamete generation (GO:0043046)4.08353777
19pore complex assembly (GO:0046931)4.04781065
20establishment of integrated proviral latency (GO:0075713)3.97068797
21meiotic chromosome segregation (GO:0045132)3.76390120
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69964309
23positive regulation of gamma-delta T cell activation (GO:0046645)3.62982054
24mitotic chromosome condensation (GO:0007076)3.59828832
25negative regulation of sister chromatid segregation (GO:0033046)3.54842303
26negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.54842303
27negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.54842303
28negative regulation of mitotic sister chromatid segregation (GO:0033048)3.54842303
29negative regulation of mitotic sister chromatid separation (GO:2000816)3.54842303
30negative regulation of chromosome segregation (GO:0051985)3.50099221
31mitotic spindle assembly checkpoint (GO:0007094)3.49308684
32histone H3-K9 demethylation (GO:0033169)3.48625289
33spindle assembly checkpoint (GO:0071173)3.47331925
34regulation of centriole replication (GO:0046599)3.47330171
35mitotic spindle checkpoint (GO:0071174)3.46750373
36superoxide anion generation (GO:0042554)3.42678763
37protein localization to chromosome (GO:0034502)3.41024500
38regulation of Golgi to plasma membrane protein transport (GO:0042996)3.40829237
39spindle checkpoint (GO:0031577)3.39038133
40DNA ligation (GO:0006266)3.37606089
41reciprocal meiotic recombination (GO:0007131)3.36480961
42reciprocal DNA recombination (GO:0035825)3.36480961
43regulation of activation of Janus kinase activity (GO:0010533)3.35273915
44CENP-A containing nucleosome assembly (GO:0034080)3.35115814
45regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.34308307
46regulation of mitotic metaphase/anaphase transition (GO:0030071)3.34308307
47DNA unwinding involved in DNA replication (GO:0006268)3.34035326
48regulation of histone H3-K9 methylation (GO:0051570)3.33579736
49dendritic cell chemotaxis (GO:0002407)3.30798338
50regulation of DNA endoreduplication (GO:0032875)3.29441992
51proteasome assembly (GO:0043248)3.28197748
52IMP metabolic process (GO:0046040)3.27023480
53regulation of mitotic sister chromatid separation (GO:0010965)3.25482856
54regulation of mitotic sister chromatid segregation (GO:0033047)3.25482856
55regulation of sister chromatid segregation (GO:0033045)3.25482856
56regulation of B cell receptor signaling pathway (GO:0050855)3.24428061
57attachment of spindle microtubules to kinetochore (GO:0008608)3.22892902
58protein localization to chromosome, centromeric region (GO:0071459)3.21567821
59cellular response to interferon-beta (GO:0035458)3.19205823
60regulation of relaxation of muscle (GO:1901077)3.18663685
61response to peptidoglycan (GO:0032494)3.17873907
62negative regulation of mast cell activation (GO:0033004)3.17199805
63mitotic sister chromatid segregation (GO:0000070)3.16413064
64regulation of RIG-I signaling pathway (GO:0039535)3.14587845
65dendritic cell migration (GO:0036336)3.13134662
66histone exchange (GO:0043486)3.12064465
67regulation of chromosome segregation (GO:0051983)3.11611472
68regulation of RNA export from nucleus (GO:0046831)3.10154778
69metaphase plate congression (GO:0051310)3.08507179
70peptidyl-threonine dephosphorylation (GO:0035970)3.08187063
71polyketide metabolic process (GO:0030638)3.06271329
72doxorubicin metabolic process (GO:0044598)3.06271329
73daunorubicin metabolic process (GO:0044597)3.06271329
74chromatin remodeling at centromere (GO:0031055)3.06007025
75sister chromatid segregation (GO:0000819)3.05868326
76protein localization to kinetochore (GO:0034501)3.04606881
77diterpenoid biosynthetic process (GO:0016102)3.04558767
78positive regulation of antigen processing and presentation (GO:0002579)3.04099041
79negative regulation of NF-kappaB import into nucleus (GO:0042347)3.03704367
80mitotic nuclear envelope disassembly (GO:0007077)3.01552579
81regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.00137189
82mast cell activation (GO:0045576)2.99777250
83energy homeostasis (GO:0097009)2.99303192
84establishment of chromosome localization (GO:0051303)2.98695587
85cellular response to exogenous dsRNA (GO:0071360)2.98332204
86DNA strand elongation involved in DNA replication (GO:0006271)2.98283987
87mitotic metaphase plate congression (GO:0007080)2.97007977
88establishment of viral latency (GO:0019043)2.95955898
89regulation of centrosome cycle (GO:0046605)2.95514695
90regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.93584213
91regulation of mitotic spindle checkpoint (GO:1903504)2.93584213
92cilium or flagellum-dependent cell motility (GO:0001539)2.92285282
93nuclear envelope disassembly (GO:0051081)2.92144349
94membrane disassembly (GO:0030397)2.92144349
95regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.91347769
96regulation of meiosis I (GO:0060631)2.88722551
97cellular response to interleukin-15 (GO:0071350)2.85745203
98modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.85229932
99positive regulation by organism of defense response of other organism involved in symbiotic interact2.85229932
100modulation by symbiont of host immune response (GO:0052553)2.85229932
101positive regulation by symbiont of host defense response (GO:0052509)2.85229932
102modulation by symbiont of host defense response (GO:0052031)2.85229932
103modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.85229932
104histone H3-K36 demethylation (GO:0070544)2.85164052
105tricarboxylic acid cycle (GO:0006099)2.84513644
106DNA replication-independent nucleosome organization (GO:0034724)2.83281855
107DNA replication-independent nucleosome assembly (GO:0006336)2.83281855
108kinetochore organization (GO:0051383)2.83093570
109DNA strand elongation (GO:0022616)2.82998260
110response to host immune response (GO:0052572)2.82679902
111response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82679902
112interferon-gamma production (GO:0032609)2.82361655
113IMP biosynthetic process (GO:0006188)2.81946324
114nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.80678542
115cellular response to type I interferon (GO:0071357)2.80142322
116type I interferon signaling pathway (GO:0060337)2.80142322
117response to type I interferon (GO:0034340)2.78621693
118T cell migration (GO:0072678)2.76816135
119regulation of nucleobase-containing compound transport (GO:0032239)2.76167629
120mesenchymal cell differentiation involved in renal system development (GO:2001012)2.76137529
121mesenchymal cell differentiation involved in kidney development (GO:0072161)2.76137529
122neutrophil activation involved in immune response (GO:0002283)2.75208346
123DNA replication checkpoint (GO:0000076)2.75016145
124regulation of centrosome duplication (GO:0010824)2.74858125
125chromosome organization (GO:0051276)2.74077523
126regulation of mast cell activation (GO:0033003)2.73750053
127germinal center formation (GO:0002467)2.73185597
128ribosome assembly (GO:0042255)2.72112352
129gene silencing by RNA (GO:0031047)2.71980484
130regulation of dendritic cell antigen processing and presentation (GO:0002604)2.71639655
131response to interferon-beta (GO:0035456)2.70991796
132AMP metabolic process (GO:0046033)2.70817361
133neutrophil activation (GO:0042119)2.70136065
134non-recombinational repair (GO:0000726)2.69476398
135double-strand break repair via nonhomologous end joining (GO:0006303)2.69476398
136regulation of acyl-CoA biosynthetic process (GO:0050812)2.67830739
137regulation of antigen processing and presentation (GO:0002577)2.66500282
138detection of molecule of bacterial origin (GO:0032490)2.66167024
139mitotic G2/M transition checkpoint (GO:0044818)2.65490352
140COPI coating of Golgi vesicle (GO:0048205)2.65269528
141Golgi transport vesicle coating (GO:0048200)2.65269528
142mannosylation (GO:0097502)2.64795060
143regulation of cofactor metabolic process (GO:0051193)2.64536990
144regulation of coenzyme metabolic process (GO:0051196)2.64536990
145negative regulation of viral genome replication (GO:0045071)2.62526482
146regulation of double-strand break repair via homologous recombination (GO:0010569)2.60201206
147G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.59994484
148regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59743234
149regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59305160
150lymphoid progenitor cell differentiation (GO:0002320)2.59065999
151cellular response to zinc ion (GO:0071294)2.58778953
152immunoglobulin mediated immune response (GO:0016064)2.58168713
153DNA strand renaturation (GO:0000733)2.58101818
154respiratory burst (GO:0045730)2.57489930
155deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56866264
156natural killer cell activation involved in immune response (GO:0002323)2.56416134
157regulation of B cell differentiation (GO:0045577)2.55893470
158regulation of mast cell degranulation (GO:0043304)2.54278186
159antigen processing and presentation of endogenous antigen (GO:0019883)2.50452268
160definitive hemopoiesis (GO:0060216)2.49605206
161* tRNA methylation (GO:0030488)2.49116358
162mature B cell differentiation (GO:0002335)2.48928674
163G-protein coupled receptor internalization (GO:0002031)2.48344383
164positive regulation of granulocyte differentiation (GO:0030854)2.47654632
165endosome to pigment granule transport (GO:0043485)2.46732393
166endosome to melanosome transport (GO:0035646)2.46732393
167regulation of mast cell activation involved in immune response (GO:0033006)2.46642520
168positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.46432003
169NIK/NF-kappaB signaling (GO:0038061)2.45592477
170positive regulation of interleukin-1 beta secretion (GO:0050718)2.44174890
171cell differentiation involved in metanephros development (GO:0072202)2.42993439
172microglial cell activation (GO:0001774)2.42577813
173production of molecular mediator involved in inflammatory response (GO:0002532)2.42113230
174detection of other organism (GO:0098543)2.41021576
175positive regulation of interferon-alpha production (GO:0032727)2.37624557
176granulocyte activation (GO:0036230)2.36426906
177positive regulation of defense response to virus by host (GO:0002230)2.36090257
178centriole assembly (GO:0098534)2.34746571
179mast cell activation involved in immune response (GO:0002279)2.34724707
180mast cell degranulation (GO:0043303)2.34724707
181detection of bacterium (GO:0016045)2.34460116
182B cell receptor signaling pathway (GO:0050853)2.33723289
183interferon-gamma-mediated signaling pathway (GO:0060333)2.33672443
184poly(A)+ mRNA export from nucleus (GO:0016973)2.32524519
185DNA deamination (GO:0045006)2.31863507
186positive regulation of mast cell degranulation (GO:0043306)2.31617384
187positive regulation of mast cell activation involved in immune response (GO:0033008)2.31617384
188regulation of nuclear cell cycle DNA replication (GO:0033262)2.31341336
189regulation of regulatory T cell differentiation (GO:0045589)2.30940165
190myeloid dendritic cell activation (GO:0001773)2.30427277
191leukocyte aggregation (GO:0070486)2.29774856
192mature B cell differentiation involved in immune response (GO:0002313)2.29132079
193B cell homeostasis (GO:0001782)2.28837291
194I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.28655666
195defense response to protozoan (GO:0042832)2.28225508
196leukocyte degranulation (GO:0043299)2.28015960
197response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.27450477
198response to host (GO:0075136)2.27450477
199response to host defenses (GO:0052200)2.27450477
200negative regulation of DNA-dependent DNA replication (GO:2000104)2.27347261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.85397969
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.82226326
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80611299
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.39261698
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.33396653
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.19890691
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.17549829
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.90724373
9PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.90709445
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.85820242
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.80955749
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.80668704
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.70467456
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.66430181
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66097239
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.63690088
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.62856216
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.57450846
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.44907466
20PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.43332098
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30935218
22GATA1_22025678_ChIP-Seq_K562_Human2.27380116
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25640792
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.25071100
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19093888
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16454740
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11316028
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.10411011
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.07903405
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07477201
31SUZ12_27294783_Chip-Seq_NPCs_Mouse2.05779495
32E2F7_22180533_ChIP-Seq_HELA_Human2.05268116
33NFE2_27457419_Chip-Seq_LIVER_Mouse2.04683626
34AR_21909140_ChIP-Seq_LNCAP_Human2.04277064
35SCL_19346495_ChIP-Seq_HPC-7_Human2.02422019
36PADI4_21655091_ChIP-ChIP_MCF-7_Human2.01670288
37DCP1A_22483619_ChIP-Seq_HELA_Human2.00616670
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97098360
39TFEB_21752829_ChIP-Seq_HELA_Human1.96866339
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95566794
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95350059
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.94770694
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93521546
44GBX2_23144817_ChIP-Seq_PC3_Human1.91751728
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.90971541
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.85975796
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.85226133
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84125483
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.83878585
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82427194
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.82126861
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81327172
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78388296
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.76939647
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.76786201
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75326994
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69083210
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68616745
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68479085
60SPI1_23547873_ChIP-Seq_NB4_Human1.66207330
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.61977984
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.61192764
63* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60453972
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57223462
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.53713802
66RUNX_20019798_ChIP-Seq_JUKART_Human1.53098343
67STAT3_18555785_Chip-Seq_ESCs_Mouse1.50052799
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49656001
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49586477
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49401945
71NMYC_18555785_Chip-Seq_ESCs_Mouse1.46330725
72SUZ12_18555785_Chip-Seq_ESCs_Mouse1.45823388
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45582451
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44820833
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44804795
76GABP_19822575_ChIP-Seq_HepG2_Human1.44020523
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41523127
78P53_22387025_ChIP-Seq_ESCs_Mouse1.40092662
79RUNX1_27457419_Chip-Seq_LIVER_Mouse1.40026372
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39885120
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39458061
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39421070
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38344034
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.37945128
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37842765
86E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37322345
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36764861
88EWS_26573619_Chip-Seq_HEK293_Human1.36195975
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.35633399
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34641022
91FUS_26573619_Chip-Seq_HEK293_Human1.33151176
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33004503
93P300_18555785_Chip-Seq_ESCs_Mouse1.32938276
94MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32428320
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32351311
96ELK1_19687146_ChIP-ChIP_HELA_Human1.31395167
97ZFX_18555785_Chip-Seq_ESCs_Mouse1.31147015
98GABP_17652178_ChIP-ChIP_JURKAT_Human1.30734286
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.30195579
100IGF1R_20145208_ChIP-Seq_DFB_Human1.29843564
101PU1_27457419_Chip-Seq_LIVER_Mouse1.28348338
102FOXP3_21729870_ChIP-Seq_TREG_Human1.28298237
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27895672
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27727909
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24901989
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22907024
107SOX2_18555785_Chip-Seq_ESCs_Mouse1.22432725
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21093888
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.20977389
110NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19856357
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19225628
112KLF4_18555785_Chip-Seq_ESCs_Mouse1.18397361
113ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18353023
114MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18319792
115ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18069828
116VDR_23849224_ChIP-Seq_CD4+_Human1.17969883
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.17683371
118CTCF_18555785_Chip-Seq_ESCs_Mouse1.17257775
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15559432
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15237096
121TAF15_26573619_Chip-Seq_HEK293_Human1.14892926
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14499495
123SMAD1_18555785_Chip-Seq_ESCs_Mouse1.14467945
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14436894
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14214086
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13665330
127P300_19829295_ChIP-Seq_ESCs_Human1.13631653
128FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12936746
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12864889
130PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11904727
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11375003
132TTF2_22483619_ChIP-Seq_HELA_Human1.10369765
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09923525
134TAL1_26923725_Chip-Seq_HPCs_Mouse1.09524479
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08746215
136MYB_26560356_Chip-Seq_TH2_Human1.05445741
137SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05298673
138HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05063981
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04486963
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03132823
141NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03080726
142XRN2_22483619_ChIP-Seq_HELA_Human1.02752732
143STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01929205
144CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01763126
145MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01685811
146CHD1_26751641_Chip-Seq_LNCaP_Human1.01429860
147YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00068077
148FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99374915
149CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98926653
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98186589
151GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98132858
152RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96029123
153MYB_26560356_Chip-Seq_TH1_Human0.94133929
154HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89559953
155SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85636183
156CIITA_25753668_ChIP-Seq_RAJI_Human0.84525834
157SOX17_20123909_ChIP-Seq_XEN_Mouse0.84446335
158ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83782231
159KDM5A_27292631_Chip-Seq_BREAST_Human0.82689601
160NANOG_16153702_ChIP-ChIP_HESCs_Human0.81101707
161TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80348359
162TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79804252
163WT1_19549856_ChIP-ChIP_CCG9911_Human0.78843390
164EGR1_19374776_ChIP-ChIP_THP-1_Human0.78274769
165TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76891612
166MYC_18940864_ChIP-ChIP_HL60_Human0.76267868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.47553616
2MP0001835_abnormal_antigen_presentation3.89760734
3MP0006292_abnormal_olfactory_placode3.65225553
4MP0004957_abnormal_blastocyst_morpholog3.05927770
5MP0001188_hyperpigmentation3.00927171
6MP0003656_abnormal_erythrocyte_physiolo2.96819635
7MP0005671_abnormal_response_to2.90944765
8MP0002148_abnormal_hypersensitivity_rea2.84395940
9MP0003646_muscle_fatigue2.79656266
10MP0002396_abnormal_hematopoietic_system2.71109197
11MP0009785_altered_susceptibility_to2.70396812
12MP0003763_abnormal_thymus_physiology2.63714925
13MP0008058_abnormal_DNA_repair2.55520002
14MP0001986_abnormal_taste_sensitivity2.51470562
15MP0001790_abnormal_immune_system2.46354414
16MP0005387_immune_system_phenotype2.46354414
17MP0001800_abnormal_humoral_immune2.34382082
18MP0003077_abnormal_cell_cycle2.23393379
19MP0000015_abnormal_ear_pigmentation2.22538109
20MP0000685_abnormal_immune_system2.19095471
21MP0003221_abnormal_cardiomyocyte_apopto2.17468737
22MP0002452_abnormal_antigen_presenting2.15769349
23MP0002419_abnormal_innate_immunity2.15616356
24MP0005000_abnormal_immune_tolerance2.13974737
25MP0005025_abnormal_response_to2.08983149
26MP0009697_abnormal_copulation2.05865108
27MP0004233_abnormal_muscle_weight2.05837939
28MP0002723_abnormal_immune_serum2.05400136
29MP0002638_abnormal_pupillary_reflex2.03750344
30MP0003724_increased_susceptibility_to2.02019266
31MP0003436_decreased_susceptibility_to2.00744483
32MP0005174_abnormal_tail_pigmentation2.00159617
33MP0001819_abnormal_immune_cell1.97603315
34MP0002420_abnormal_adaptive_immunity1.96442045
35MP0001929_abnormal_gametogenesis1.95069268
36MP0002210_abnormal_sex_determination1.94300059
37MP0005645_abnormal_hypothalamus_physiol1.89568956
38MP0005075_abnormal_melanosome_morpholog1.86390363
39MP0005646_abnormal_pituitary_gland1.82123188
40MP0008932_abnormal_embryonic_tissue1.79908156
41MP0002877_abnormal_melanocyte_morpholog1.78412584
42MP0001730_embryonic_growth_arrest1.74458644
43MP0002269_muscular_atrophy1.66585118
44MP0002398_abnormal_bone_marrow1.65816814
45MP0003806_abnormal_nucleotide_metabolis1.63810223
46MP0001853_heart_inflammation1.63178045
47MP0002132_abnormal_respiratory_system1.62856467
48MP0002277_abnormal_respiratory_mucosa1.61599940
49MP0001145_abnormal_male_reproductive1.59497932
50MP0010307_abnormal_tumor_latency1.58649417
51MP0004036_abnormal_muscle_relaxation1.56396789
52MP0001661_extended_life_span1.56235253
53MP0004145_abnormal_muscle_electrophysio1.55998020
54MP0002095_abnormal_skin_pigmentation1.54770218
55MP0002009_preneoplasia1.54404428
56MP0000716_abnormal_immune_system1.53332972
57MP0008260_abnormal_autophagy1.51678410
58MP0006036_abnormal_mitochondrial_physio1.51398006
59MP0005379_endocrine/exocrine_gland_phen1.49133251
60MP0003136_yellow_coat_color1.48904485
61MP0008057_abnormal_DNA_replication1.48666785
62MP0000653_abnormal_sex_gland1.47547179
63MP0009764_decreased_sensitivity_to1.45728732
64MP0002405_respiratory_system_inflammati1.44460289
65MP0000749_muscle_degeneration1.44093399
66MP0005409_darkened_coat_color1.42676198
67MP0005380_embryogenesis_phenotype1.40851551
68MP0001672_abnormal_embryogenesis/_devel1.40851551
69MP0008007_abnormal_cellular_replicative1.39833817
70MP0003693_abnormal_embryo_hatching1.39244575
71MP0001697_abnormal_embryo_size1.39219820
72MP0003183_abnormal_peptide_metabolism1.38788646
73MP0003984_embryonic_growth_retardation1.37298360
74MP0004147_increased_porphyrin_level1.36589703
75MP0003718_maternal_effect1.36502879
76MP0000350_abnormal_cell_proliferation1.33982049
77MP0003941_abnormal_skin_development1.33416708
78MP0002088_abnormal_embryonic_growth/wei1.33035381
79MP0000689_abnormal_spleen_morphology1.29552501
80MP0010094_abnormal_chromosome_stability1.28553106
81MP0002722_abnormal_immune_system1.26514885
82MP0005310_abnormal_salivary_gland1.25743399
83MP0010155_abnormal_intestine_physiology1.23734092
84MP0002429_abnormal_blood_cell1.23400431
85MP0006035_abnormal_mitochondrial_morpho1.22876873
86MP0004484_altered_response_of1.21551551
87MP0009333_abnormal_splenocyte_physiolog1.21364423
88MP0002084_abnormal_developmental_patter1.21123948
89MP0005464_abnormal_platelet_physiology1.20455641
90MP0005330_cardiomyopathy1.20115778
91MP0000703_abnormal_thymus_morphology1.19961235
92MP0002876_abnormal_thyroid_physiology1.19212846
93MP0003698_abnormal_male_reproductive1.19075653
94MP0002166_altered_tumor_susceptibility1.17713551
95MP0004381_abnormal_hair_follicle1.16915367
96MP0002006_tumorigenesis1.16664161
97MP0001873_stomach_inflammation1.15608785
98MP0001845_abnormal_inflammatory_respons1.15102072
99MP0004084_abnormal_cardiac_muscle1.14282491
100MP0000313_abnormal_cell_death1.12034557
101MP0003111_abnormal_nucleus_morphology1.11090200
102MP0000490_abnormal_crypts_of1.10801228
103MP0000747_muscle_weakness1.10213055
104MP0002080_prenatal_lethality1.10048693
105MP0009703_decreased_birth_body1.08888701
106MP0003943_abnormal_hepatobiliary_system1.07421345
107MP0002160_abnormal_reproductive_system1.07277228
108MP0004782_abnormal_surfactant_physiolog1.05729273
109MP0002837_dystrophic_cardiac_calcinosis1.05646142
110MP0003890_abnormal_embryonic-extraembry1.04738329
111MP0001502_abnormal_circadian_rhythm1.04510246
112MP0004215_abnormal_myocardial_fiber1.04017531
113MP0005389_reproductive_system_phenotype1.03524327
114MP0002928_abnormal_bile_duct1.03237115
115MP0005171_absent_coat_pigmentation1.01847753
116MP0002086_abnormal_extraembryonic_tissu1.00079917
117MP0004808_abnormal_hematopoietic_stem1.00077160
118MP0002163_abnormal_gland_morphology0.99649960
119MP0004197_abnormal_fetal_growth/weight/0.98357380
120MP0004264_abnormal_extraembryonic_tissu0.98146724
121MP0005076_abnormal_cell_differentiation0.97482686
122MP0004087_abnormal_muscle_fiber0.97049913
123MP0000751_myopathy0.94120677
124MP0009672_abnormal_birth_weight0.93581962
125MP0010352_gastrointestinal_tract_polyps0.92795346
126MP0008469_abnormal_protein_level0.91593982
127MP0002938_white_spotting0.91332376
128MP0002254_reproductive_system_inflammat0.90920853
129MP0003786_premature_aging0.90425368
130MP0003186_abnormal_redox_activity0.90030529
131MP0000358_abnormal_cell_content/0.89979131
132MP0000566_synostosis0.89754685
133MP0002019_abnormal_tumor_incidence0.89729501
134MP0004185_abnormal_adipocyte_glucose0.88486139
135MP0005266_abnormal_metabolism0.88369420
136MP0003828_pulmonary_edema0.87486206
137MP0002106_abnormal_muscle_physiology0.86836941
138MP0005451_abnormal_body_composition0.86677668
139MP0005670_abnormal_white_adipose0.86490150
140MP0005551_abnormal_eye_electrophysiolog0.86485620
141MP0000427_abnormal_hair_cycle0.86414570
142MP0000372_irregular_coat_pigmentation0.86156869
143MP0003950_abnormal_plasma_membrane0.86005801
144MP0002085_abnormal_embryonic_tissue0.85337298
145MP0003699_abnormal_female_reproductive0.84193889
146MP0005384_cellular_phenotype0.84124165
147MP0000465_gastrointestinal_hemorrhage0.82061107
148MP0000678_abnormal_parathyroid_gland0.80435031
149MP0006082_CNS_inflammation0.80432494
150MP0005253_abnormal_eye_physiology0.80330426
151MP0002332_abnormal_exercise_endurance0.80095631
152MP0000858_altered_metastatic_potential0.80009828
153MP0000681_abnormal_thyroid_gland0.79702249
154MP0005621_abnormal_cell_physiology0.78794105
155MP0001984_abnormal_olfaction0.78393219
156MP0001727_abnormal_embryo_implantation0.78265512
157MP0005397_hematopoietic_system_phenotyp0.77318745
158MP0001545_abnormal_hematopoietic_system0.77318745
159MP0001764_abnormal_homeostasis0.76804835
160MP0002161_abnormal_fertility/fecundity0.74795346
161MP0010630_abnormal_cardiac_muscle0.73774866
162MP0002127_abnormal_cardiovascular_syste0.73062216
163MP0001533_abnormal_skeleton_physiology0.72132986
164MP0001915_intracranial_hemorrhage0.72066234
165MP0004510_myositis0.71642419
166MP0005083_abnormal_biliary_tract0.71238939
167MP0001919_abnormal_reproductive_system0.71073817
168MP0008995_early_reproductive_senescence0.70140402
169MP0002933_joint_inflammation0.69476942
170MP0000371_diluted_coat_color0.68634123
171MP0001186_pigmentation_phenotype0.68379275
172MP0003787_abnormal_imprinting0.68310091
173MP0001119_abnormal_female_reproductive0.66536765

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)5.03951510
2Muscle fiber inclusion bodies (HP:0100299)4.75164360
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.64406129
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.41156327
5Chromsome breakage (HP:0040012)4.12867588
6Exercise-induced muscle cramps (HP:0003710)3.96591341
7Rimmed vacuoles (HP:0003805)3.77685211
8Shoulder girdle muscle weakness (HP:0003547)3.54819027
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.47486569
10True hermaphroditism (HP:0010459)3.45038147
11Gonadotropin excess (HP:0000837)3.41628268
12Recurrent abscess formation (HP:0002722)3.35498485
13Type I transferrin isoform profile (HP:0003642)3.28965494
14Prostate neoplasm (HP:0100787)3.21705743
15Tubulointerstitial nephritis (HP:0001970)3.14885798
16Progressive external ophthalmoplegia (HP:0000590)3.12687962
17Congenital stationary night blindness (HP:0007642)3.10394916
18Volvulus (HP:0002580)3.07731399
19IgM deficiency (HP:0002850)3.07288885
20Abnormality of DNA repair (HP:0003254)3.05104871
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94595956
22Nephroblastoma (Wilms tumor) (HP:0002667)2.83331974
23Retrobulbar optic neuritis (HP:0100654)2.82385440
24Optic neuritis (HP:0100653)2.82385440
25Recurrent bacterial skin infections (HP:0005406)2.79495974
26Pelvic girdle muscle weakness (HP:0003749)2.76980016
27Myositis (HP:0100614)2.73766861
28Recurrent cutaneous fungal infections (HP:0011370)2.73538230
29Chronic mucocutaneous candidiasis (HP:0002728)2.73538230
30Progressive muscle weakness (HP:0003323)2.72252126
31Reduced antithrombin III activity (HP:0001976)2.71614811
32Embryonal renal neoplasm (HP:0011794)2.69146848
33Azoospermia (HP:0000027)2.67500696
34Exercise-induced myalgia (HP:0003738)2.66003673
35Mediastinal lymphadenopathy (HP:0100721)2.65105699
36Duplicated collecting system (HP:0000081)2.64822939
37Agammaglobulinemia (HP:0004432)2.59428514
38Abnormality of the anterior horn cell (HP:0006802)2.57298740
39Degeneration of anterior horn cells (HP:0002398)2.57298740
40Abnormal respiratory motile cilium physiology (HP:0012261)2.57056726
41Recurrent fungal infections (HP:0002841)2.56369337
42Meningitis (HP:0001287)2.54489003
43Abnormality of the left ventricular outflow tract (HP:0011103)2.53427712
44Subaortic stenosis (HP:0001682)2.53427712
45Muscle fiber splitting (HP:0003555)2.51021219
46Abnormality of the renal collecting system (HP:0004742)2.50943363
47Petechiae (HP:0000967)2.50523250
48Chronic obstructive pulmonary disease (HP:0006510)2.49458734
49Obstructive lung disease (HP:0006536)2.49458734
50Abnormal spermatogenesis (HP:0008669)2.48640393
51Recurrent pneumonia (HP:0006532)2.48020937
52Pancreatic fibrosis (HP:0100732)2.46083106
53Myopathic facies (HP:0002058)2.46038152
54Myoglobinuria (HP:0002913)2.45126287
55Chronic sinusitis (HP:0011109)2.44231842
56Eczematoid dermatitis (HP:0000976)2.41411367
57Clubbing of toes (HP:0100760)2.37196697
58Duodenal stenosis (HP:0100867)2.36654396
59Small intestinal stenosis (HP:0012848)2.36654396
60Bronchiectasis (HP:0002110)2.35826026
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.34878018
62Absent/shortened dynein arms (HP:0200106)2.34878018
63Chronic otitis media (HP:0000389)2.34145774
64Prolonged bleeding time (HP:0003010)2.33346210
65Encephalitis (HP:0002383)2.32993261
66Abnormality of the prostate (HP:0008775)2.31551543
67Recurrent skin infections (HP:0001581)2.30647720
68Bundle branch block (HP:0011710)2.30469969
69Gout (HP:0001997)2.27405179
70Rhinitis (HP:0012384)2.27240737
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26770533
72Abnormality of the preputium (HP:0100587)2.26225337
73EMG: myopathic abnormalities (HP:0003458)2.25902615
74Panhypogammaglobulinemia (HP:0003139)2.25705762
75Increased nuchal translucency (HP:0010880)2.25628893
76Abnormal ciliary motility (HP:0012262)2.24907419
77Papillary thyroid carcinoma (HP:0002895)2.23611582
78Rhabdomyolysis (HP:0003201)2.23402622
79Stomach cancer (HP:0012126)2.23180638
80Vasculitis (HP:0002633)2.22858215
81Abnormality of the hip-girdle musculature (HP:0001445)2.22189739
82Abnormality of the musculature of the pelvis (HP:0001469)2.22189739
83White forelock (HP:0002211)2.21075481
84Renal cortical cysts (HP:0000803)2.20503275
85Recurrent lower respiratory tract infections (HP:0002783)2.19056985
86Neutropenia (HP:0001875)2.16551004
87Pancreatic cysts (HP:0001737)2.15769087
88Cortical dysplasia (HP:0002539)2.15289840
89Lymphopenia (HP:0001888)2.14736074
90Male infertility (HP:0003251)2.14101426
91Patchy hypopigmentation of hair (HP:0011365)2.13594496
92Abnormality of T cell physiology (HP:0011840)2.13414304
93Recurrent sinusitis (HP:0011108)2.12279408
94Abnormality of the columella (HP:0009929)2.12228298
95Chronic bronchitis (HP:0004469)2.12168278
96Orchitis (HP:0100796)2.11719544
97Abnormality of secondary sexual hair (HP:0009888)2.11149610
98Abnormality of the axillary hair (HP:0100134)2.11149610
99Chronic diarrhea (HP:0002028)2.10977296
100Neoplasm of the colon (HP:0100273)2.10758668
101Large hands (HP:0001176)2.09962649
102Elevated erythrocyte sedimentation rate (HP:0003565)2.09606986
103Albinism (HP:0001022)2.09042629
104Chronic hepatic failure (HP:0100626)2.08944365
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08706487
106Abnormal protein N-linked glycosylation (HP:0012347)2.08706487
107Abnormal protein glycosylation (HP:0012346)2.08706487
108Abnormal glycosylation (HP:0012345)2.08706487
109Basal ganglia calcification (HP:0002135)2.08455156
110Abnormality of chromosome stability (HP:0003220)2.08131690
111Abnormal rod and cone electroretinograms (HP:0008323)2.07575930
112Abnormality of methionine metabolism (HP:0010901)2.06591155
113Recurrent viral infections (HP:0004429)2.06486193
114Recurrent bronchitis (HP:0002837)2.06395511
115Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04717975
116Tetraparesis (HP:0002273)2.04122721
117Abnormality of T cells (HP:0002843)2.04001865
118Abnormality of cells of the lymphoid lineage (HP:0012140)2.03395778
119IgG deficiency (HP:0004315)2.02172317
120Granulocytopenia (HP:0001913)2.01831114
121Birth length less than 3rd percentile (HP:0003561)2.01808615
122Abnormal respiratory epithelium morphology (HP:0012253)2.01753119
123Abnormal respiratory motile cilium morphology (HP:0005938)2.01753119
124Increased IgM level (HP:0003496)2.00095456
125Type 2 muscle fiber atrophy (HP:0003554)1.99907458
126Congenital sensorineural hearing impairment (HP:0008527)1.99267169
127Hypothermia (HP:0002045)1.99224583
128Abnormality of male internal genitalia (HP:0000022)1.98940570
129Neck muscle weakness (HP:0000467)1.97657175
130Abnormality of macrophages (HP:0004311)1.97406056
131Myelodysplasia (HP:0002863)1.96444146
132Abnormal hair whorl (HP:0010721)1.95879793
133Ectopic kidney (HP:0000086)1.95182924
134Atrophy/Degeneration involving motor neurons (HP:0007373)1.94907568
135Median cleft lip (HP:0000161)1.94779126
136Ragged-red muscle fibers (HP:0003200)1.94759015
137Gingivitis (HP:0000230)1.94681044
138Aplastic anemia (HP:0001915)1.93220471
139Centrally nucleated skeletal muscle fibers (HP:0003687)1.92728997
140Recurrent gram-negative bacterial infections (HP:0005420)1.92080455
141Increased serum pyruvate (HP:0003542)1.91785188
142Aplasia/Hypoplasia of the uvula (HP:0010293)1.91622634
143Pulmonary infiltrates (HP:0002113)1.91294096
144Optic nerve coloboma (HP:0000588)1.91239008
145Cafe-au-lait spot (HP:0000957)1.90864552
146Hand muscle atrophy (HP:0009130)1.90353050
147Diaphragmatic weakness (HP:0009113)1.90112723
148Abnormal lung lobation (HP:0002101)1.90091472
149Dry hair (HP:0011359)1.89888468
150Rhabdomyosarcoma (HP:0002859)1.89841023
151T lymphocytopenia (HP:0005403)1.89780669
152Entropion (HP:0000621)1.89096911
153Hypoplasia of the fovea (HP:0007750)1.88636835
154Aplasia/Hypoplasia of the fovea (HP:0008060)1.88636835
155Medial flaring of the eyebrow (HP:0010747)1.88225973
156Lymphoma (HP:0002665)1.88201583
157Submucous cleft hard palate (HP:0000176)1.87706325
158Thyroid-stimulating hormone excess (HP:0002925)1.86676986
159Nephrogenic diabetes insipidus (HP:0009806)1.86051741
160Acute lymphatic leukemia (HP:0006721)1.85762010
161Meckel diverticulum (HP:0002245)1.84625758
162Degeneration of the lateral corticospinal tracts (HP:0002314)1.82670564
163Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82670564
164Supernumerary spleens (HP:0009799)1.81270209
165Short tibia (HP:0005736)1.80612062
166Neuroendocrine neoplasm (HP:0100634)1.77947077
167Proximal placement of thumb (HP:0009623)1.77153516
168Abnormality of the duodenum (HP:0002246)1.75680094
169Pheochromocytoma (HP:0002666)1.75677572
170Ovarian neoplasm (HP:0100615)1.75533980
171Sloping forehead (HP:0000340)1.75340962
172Abnormality of the ileum (HP:0001549)1.73860889
173Absent radius (HP:0003974)1.72271817
174Osteomalacia (HP:0002749)1.69064618
175Thyroid carcinoma (HP:0002890)1.68027646
176Infertility (HP:0000789)1.64617723
177Medulloblastoma (HP:0002885)1.64314315
178Cholelithiasis (HP:0001081)1.64256238
179Limb-girdle muscle atrophy (HP:0003797)1.63499541
180Abnormality of glycolysis (HP:0004366)1.62777245
181Bowel incontinence (HP:0002607)1.61262915
182Embryonal neoplasm (HP:0002898)1.59198725
183Abnormal large intestine physiology (HP:0012700)1.58145838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.95489015
2TTK3.69939506
3TXK3.54553498
4OBSCN3.39037573
5IRAK33.25285434
6MAP3K143.10152687
7ZAK2.97012350
8IRAK42.79898274
9BUB12.62183701
10MAP4K12.59378402
11NEK92.51837111
12BCR2.27651432
13KSR12.21238032
14STK162.10624558
15TNIK2.10228869
16CDK122.09829131
17MAP4K22.09085989
18FLT32.04974146
19KIT2.04736603
20NEK12.02220702
21TEC2.01338088
22YES11.89889015
23CASK1.87934612
24MKNK21.77341517
25JAK31.77119078
26BMPR21.75383637
27RIPK41.73011766
28MAP2K21.70532904
29TSSK61.70279545
30TNK21.68403468
31CDC71.65997051
32ADRBK21.64397040
33NLK1.63265240
34CDK191.59696735
35INSRR1.59361589
36BTK1.57280638
37IKBKE1.55626011
38EIF2AK11.49242975
39IKBKB1.48774756
40SIK31.44735459
41BMPR1B1.44211640
42PDK21.40755118
43PNCK1.38758056
44MUSK1.37250473
45EIF2AK21.36995678
46TYK21.35836071
47PIK3CG1.35670862
48TAF11.33457310
49GRK11.30507167
50PLK11.30477879
51PIM21.29515427
52KSR21.28651457
53MAP3K121.27284553
54BLK1.26905970
55MAPK151.23661108
56BRAF1.19965068
57MKNK11.17440638
58IRAK11.13491368
59VRK11.12972938
60TAOK31.12205685
61MAP3K21.11629284
62MET1.11056124
63WEE11.10609803
64LYN1.09697788
65ZAP701.09600353
66SYK1.08446785
67PLK31.08023388
68ERBB31.06951795
69CDK61.05177546
70MAP2K71.04187787
71SGK21.00702966
72NEK60.99676536
73BRD40.99073102
74CHUK0.98981641
75STK240.98319047
76CHEK10.96994246
77MAP3K130.95762710
78MAP3K100.95709200
79TBK10.94934441
80PLK40.94283792
81SRPK10.94283507
82GRK70.93650069
83TESK20.93437669
84EPHA30.91944065
85LIMK10.90866736
86FGR0.90422043
87ATR0.90340020
88CCNB10.89950634
89RAF10.85087713
90MAP3K50.84816175
91CDK30.84454273
92AKT30.83931270
93LCK0.83628903
94JAK10.83203057
95PRPF4B0.77920683
96CLK10.77540832
97NEK20.76751880
98CDK40.76311066
99STK40.74793580
100STK100.73954512
101PIM10.73502623
102TTN0.73355548
103DYRK30.71843759
104GRK60.69460007
105CSF1R0.69364152
106HCK0.68740206
107CAMKK20.67275886
108MST1R0.66601981
109NUAK10.66393591
110TAOK20.66068279
111PTK2B0.65418610
112PBK0.64542458
113TIE10.63995373
114RIPK10.62845108
115PHKG20.62724419
116PHKG10.62724419
117STK30.62603179
118MST40.59164581
119CDK80.59099479
120MAP3K80.55223165
121OXSR10.54180658
122TRPM70.53755444
123SCYL20.53181029
124RPS6KA40.51328724
125FES0.51243246
126WNK30.49187456
127CDK70.48741271
128AURKB0.46331095
129BRSK20.46079991
130MELK0.45831311
131DYRK1A0.44647793
132MAPK70.44183018
133BMX0.43236893
134CDK90.43109001
135CSK0.40819809
136ITK0.40544651
137EGFR0.40494262
138RPS6KA50.39958380
139MAP2K10.39930547
140PRKCD0.39654800
141PIK3CA0.38935344
142EIF2AK30.38229915
143PRKCQ0.38163137
144AURKA0.37429275
145CDK20.36942689
146MAPK30.36758086
147SGK30.36725899
148JAK20.36616394
149TGFBR20.35472153
150PLK20.34771022
151ACVR1B0.34434323
152STK38L0.33945419
153CHEK20.32669076
154ATM0.32561702
155ABL10.31995345
156PRKCE0.31677694
157PASK0.31545038
158CDK10.30531525
159MATK0.30394843
160RPS6KB10.30040873
161BRSK10.29822414
162RPS6KB20.29778174
163LMTK20.29474130

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.13850293
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.05024091
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.98260778
4Homologous recombination_Homo sapiens_hsa034402.62899766
5Fanconi anemia pathway_Homo sapiens_hsa034602.59769649
6Primary immunodeficiency_Homo sapiens_hsa053402.54360115
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.46772994
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.34438537
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32040501
10RNA transport_Homo sapiens_hsa030132.31306314
11Allograft rejection_Homo sapiens_hsa053302.31254981
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.10417730
13Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.03367734
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02270307
15Measles_Homo sapiens_hsa051622.00933222
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97788328
17Non-homologous end-joining_Homo sapiens_hsa034501.96040484
18Graft-versus-host disease_Homo sapiens_hsa053321.95670206
19Propanoate metabolism_Homo sapiens_hsa006401.94775760
20Oocyte meiosis_Homo sapiens_hsa041141.85994863
21Hematopoietic cell lineage_Homo sapiens_hsa046401.82129323
22Autoimmune thyroid disease_Homo sapiens_hsa053201.76991653
23Herpes simplex infection_Homo sapiens_hsa051681.75657148
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69382221
25Pyruvate metabolism_Homo sapiens_hsa006201.68026024
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67965860
27Leishmaniasis_Homo sapiens_hsa051401.65552217
28mRNA surveillance pathway_Homo sapiens_hsa030151.59260687
29Carbon metabolism_Homo sapiens_hsa012001.59033969
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57251943
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.57180584
32DNA replication_Homo sapiens_hsa030301.55236206
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53496330
34Mismatch repair_Homo sapiens_hsa034301.52959722
35Phototransduction_Homo sapiens_hsa047441.50778515
36RNA polymerase_Homo sapiens_hsa030201.48935527
37Base excision repair_Homo sapiens_hsa034101.47150212
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46579035
39Fatty acid elongation_Homo sapiens_hsa000621.42794995
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41141079
41Basal transcription factors_Homo sapiens_hsa030221.39809722
42Influenza A_Homo sapiens_hsa051641.38127139
43Type I diabetes mellitus_Homo sapiens_hsa049401.37531475
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37233140
45Pyrimidine metabolism_Homo sapiens_hsa002401.36797680
46Biosynthesis of amino acids_Homo sapiens_hsa012301.35526792
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.35457709
48Pentose phosphate pathway_Homo sapiens_hsa000301.35080371
49Asthma_Homo sapiens_hsa053101.34166068
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29996407
51RNA degradation_Homo sapiens_hsa030181.29146081
52Phenylalanine metabolism_Homo sapiens_hsa003601.28194157
53Protein export_Homo sapiens_hsa030601.26576340
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26147400
55Legionellosis_Homo sapiens_hsa051341.22990432
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22145052
57Thyroid cancer_Homo sapiens_hsa052161.20191121
58Osteoclast differentiation_Homo sapiens_hsa043801.12697780
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12077790
60Other glycan degradation_Homo sapiens_hsa005111.11356472
61Nucleotide excision repair_Homo sapiens_hsa034201.07820875
62One carbon pool by folate_Homo sapiens_hsa006701.07793724
63Purine metabolism_Homo sapiens_hsa002301.07260882
64B cell receptor signaling pathway_Homo sapiens_hsa046621.06861501
65Rheumatoid arthritis_Homo sapiens_hsa053231.06552872
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05984128
67Sphingolipid metabolism_Homo sapiens_hsa006001.04899199
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03179889
69Antigen processing and presentation_Homo sapiens_hsa046121.02566176
70Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01399137
71Sulfur relay system_Homo sapiens_hsa041220.98581533
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96755255
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95427270
74TNF signaling pathway_Homo sapiens_hsa046680.93941282
75Malaria_Homo sapiens_hsa051440.93444706
76Tuberculosis_Homo sapiens_hsa051520.91536067
77Circadian rhythm_Homo sapiens_hsa047100.91222009
78p53 signaling pathway_Homo sapiens_hsa041150.90478045
79Arachidonic acid metabolism_Homo sapiens_hsa005900.90198804
80Regulation of autophagy_Homo sapiens_hsa041400.88921728
81Spliceosome_Homo sapiens_hsa030400.83738307
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80220199
83Vitamin digestion and absorption_Homo sapiens_hsa049770.78911476
84Fatty acid metabolism_Homo sapiens_hsa012120.77944852
85Viral carcinogenesis_Homo sapiens_hsa052030.77220201
86Pertussis_Homo sapiens_hsa051330.76357420
87Hepatitis B_Homo sapiens_hsa051610.73287598
88African trypanosomiasis_Homo sapiens_hsa051430.70255709
89Chemokine signaling pathway_Homo sapiens_hsa040620.70085434
90Non-small cell lung cancer_Homo sapiens_hsa052230.69344740
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67396411
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66799226
93Apoptosis_Homo sapiens_hsa042100.66317045
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66289200
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65856153
96Toxoplasmosis_Homo sapiens_hsa051450.64732261
97Fructose and mannose metabolism_Homo sapiens_hsa000510.64702392
98Cell cycle_Homo sapiens_hsa041100.63517279
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61513300
100Ribosome_Homo sapiens_hsa030100.61013733
101Epstein-Barr virus infection_Homo sapiens_hsa051690.60409773
102Selenocompound metabolism_Homo sapiens_hsa004500.60257960
103Arginine and proline metabolism_Homo sapiens_hsa003300.59969907
104Nicotine addiction_Homo sapiens_hsa050330.59128588
105Staphylococcus aureus infection_Homo sapiens_hsa051500.59074560
106Fatty acid degradation_Homo sapiens_hsa000710.58581944
107T cell receptor signaling pathway_Homo sapiens_hsa046600.57467796
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.57410637
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57363884
110Insulin signaling pathway_Homo sapiens_hsa049100.57292772
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56762892
112Tyrosine metabolism_Homo sapiens_hsa003500.56244729
113ABC transporters_Homo sapiens_hsa020100.53833269
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52916215
115Salmonella infection_Homo sapiens_hsa051320.52569121
116Hepatitis C_Homo sapiens_hsa051600.52093823
117Chronic myeloid leukemia_Homo sapiens_hsa052200.49997044
118beta-Alanine metabolism_Homo sapiens_hsa004100.48745674
119Glutathione metabolism_Homo sapiens_hsa004800.45536332
120Acute myeloid leukemia_Homo sapiens_hsa052210.45264860
121Proteasome_Homo sapiens_hsa030500.45119820
122Peroxisome_Homo sapiens_hsa041460.45050431
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43842769
124Starch and sucrose metabolism_Homo sapiens_hsa005000.43338372
125Small cell lung cancer_Homo sapiens_hsa052220.43320580
126HTLV-I infection_Homo sapiens_hsa051660.40893043
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40328438
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40324317
129Huntingtons disease_Homo sapiens_hsa050160.39332730
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38388032
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.37899139
132Prostate cancer_Homo sapiens_hsa052150.37210927
133Renal cell carcinoma_Homo sapiens_hsa052110.36750933
134Pancreatic cancer_Homo sapiens_hsa052120.36685578
135Inositol phosphate metabolism_Homo sapiens_hsa005620.35245611
136Phagosome_Homo sapiens_hsa041450.35062391
137Folate biosynthesis_Homo sapiens_hsa007900.34937908
138Arginine biosynthesis_Homo sapiens_hsa002200.34327594
139Taste transduction_Homo sapiens_hsa047420.33962157
140Adherens junction_Homo sapiens_hsa045200.33881217
141N-Glycan biosynthesis_Homo sapiens_hsa005100.33469039
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33265769
143Glucagon signaling pathway_Homo sapiens_hsa049220.33200203
144Galactose metabolism_Homo sapiens_hsa000520.31912894
145Shigellosis_Homo sapiens_hsa051310.31838967
146Morphine addiction_Homo sapiens_hsa050320.31784741
147Glioma_Homo sapiens_hsa052140.30397319
148Metabolic pathways_Homo sapiens_hsa011000.29445364
149Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28187717
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27247406
151Notch signaling pathway_Homo sapiens_hsa043300.27105493
152Serotonergic synapse_Homo sapiens_hsa047260.26669380
153AMPK signaling pathway_Homo sapiens_hsa041520.25978711
154Central carbon metabolism in cancer_Homo sapiens_hsa052300.24043743
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23722638
156Retinol metabolism_Homo sapiens_hsa008300.19101004

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