TRMT2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.13729135
2viral transcription (GO:0019083)5.92972014
3translational termination (GO:0006415)5.75600728
4DNA strand elongation involved in DNA replication (GO:0006271)5.34402317
5negative regulation of erythrocyte differentiation (GO:0045647)5.18540808
6maturation of SSU-rRNA (GO:0030490)5.14860499
7telomere maintenance via semi-conservative replication (GO:0032201)5.14646823
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.11419546
9ribosomal small subunit biogenesis (GO:0042274)5.10739737
10translational elongation (GO:0006414)5.10086288
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.09865517
12DNA strand elongation (GO:0022616)5.09693932
13cotranslational protein targeting to membrane (GO:0006613)4.98292163
14protein targeting to ER (GO:0045047)4.96735776
15DNA deamination (GO:0045006)4.93314009
16establishment of protein localization to endoplasmic reticulum (GO:0072599)4.75505839
17DNA unwinding involved in DNA replication (GO:0006268)4.73481863
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.70281024
19protein localization to endoplasmic reticulum (GO:0070972)4.67063401
20translational initiation (GO:0006413)4.54152267
21viral life cycle (GO:0019058)4.52109332
22cellular protein complex disassembly (GO:0043624)4.43756273
23telomere maintenance via recombination (GO:0000722)4.43458971
24DNA replication initiation (GO:0006270)4.42261982
25ribosomal large subunit biogenesis (GO:0042273)4.31775610
26mannose metabolic process (GO:0006013)4.29176554
27protein complex disassembly (GO:0043241)4.11561385
28mitotic recombination (GO:0006312)4.09179531
29GDP-mannose metabolic process (GO:0019673)3.97583628
30macromolecular complex disassembly (GO:0032984)3.91767305
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.88119624
32DNA replication checkpoint (GO:0000076)3.84070554
33telomere maintenance via telomere lengthening (GO:0010833)3.83380817
34nucleobase biosynthetic process (GO:0046112)3.82952232
35nuclear-transcribed mRNA catabolic process (GO:0000956)3.78453094
36ribonucleoprotein complex biogenesis (GO:0022613)3.75503863
37formation of translation preinitiation complex (GO:0001731)3.65496086
38mRNA catabolic process (GO:0006402)3.64577616
39RNA catabolic process (GO:0006401)3.54054541
40protein localization to kinetochore (GO:0034501)3.52660892
41translation (GO:0006412)3.51824884
42response to peptidoglycan (GO:0032494)3.51677847
43negative regulation of RNA splicing (GO:0033119)3.50010425
44positive regulation of gamma-delta T cell activation (GO:0046645)3.45520907
45rRNA processing (GO:0006364)3.45041114
46IMP biosynthetic process (GO:0006188)3.43061271
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.42754481
48regulation of translational fidelity (GO:0006450)3.41887811
49proline biosynthetic process (GO:0006561)3.40312151
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40195971
51pseudouridine synthesis (GO:0001522)3.32706287
52rRNA metabolic process (GO:0016072)3.31625834
53translesion synthesis (GO:0019985)3.28445124
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25217548
55CENP-A containing nucleosome assembly (GO:0034080)3.24968698
56regulation of mammary gland epithelial cell proliferation (GO:0033599)3.24455456
57UV protection (GO:0009650)3.24170706
58protein targeting to membrane (GO:0006612)3.22327421
59spliceosomal snRNP assembly (GO:0000387)3.21067510
60protein localization to chromosome, centromeric region (GO:0071459)3.19649616
61IMP metabolic process (GO:0046040)3.19199824
62DNA replication-independent nucleosome organization (GO:0034724)3.19197567
63DNA replication-independent nucleosome assembly (GO:0006336)3.19197567
64tRNA methylation (GO:0030488)3.17987408
65folic acid metabolic process (GO:0046655)3.16669121
66histone H2A acetylation (GO:0043968)3.16654984
67ncRNA 3-end processing (GO:0043628)3.16122730
68intra-S DNA damage checkpoint (GO:0031573)3.15215017
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15118436
70folic acid-containing compound biosynthetic process (GO:0009396)3.14313207
71chromatin remodeling at centromere (GO:0031055)3.12387274
72purine nucleobase biosynthetic process (GO:0009113)3.09361814
73ribosome biogenesis (GO:0042254)3.09051912
74proteasome assembly (GO:0043248)3.06316841
75DNA duplex unwinding (GO:0032508)3.06215886
76spliceosomal complex assembly (GO:0000245)3.05460998
77DNA geometric change (GO:0032392)3.03896770
78regulation of monocyte differentiation (GO:0045655)3.03813398
79mRNA splicing, via spliceosome (GO:0000398)3.03173049
80RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.03173049
81DNA replication-dependent nucleosome assembly (GO:0006335)3.00562912
82DNA replication-dependent nucleosome organization (GO:0034723)3.00562912
83RNA splicing, via transesterification reactions (GO:0000375)3.00510901
84response to muramyl dipeptide (GO:0032495)3.00216443
85mitochondrial DNA replication (GO:0006264)2.98771405
86regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98745888
87establishment of integrated proviral latency (GO:0075713)2.98679136
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97684821
89termination of RNA polymerase II transcription (GO:0006369)2.97285331
90spliceosomal tri-snRNP complex assembly (GO:0000244)2.96309719
91viral mRNA export from host cell nucleus (GO:0046784)2.95426209
92regulation of chromatin binding (GO:0035561)2.93453347
93peptidyl-arginine omega-N-methylation (GO:0035247)2.93175119
94histone mRNA metabolic process (GO:0008334)2.90962112
95NIK/NF-kappaB signaling (GO:0038061)2.90921899
96telomere organization (GO:0032200)2.90525743
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.89904614
98telomere maintenance (GO:0000723)2.89788653
99transcription-coupled nucleotide-excision repair (GO:0006283)2.88362676
100negative regulation of mRNA processing (GO:0050686)2.87039841
101cellular component biogenesis (GO:0044085)2.86090970
102base-excision repair (GO:0006284)2.83748324
103negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.82371321
104modulation by virus of host process (GO:0019054)2.80502005
105maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80430772
106mature B cell differentiation involved in immune response (GO:0002313)2.80390487
107intracellular estrogen receptor signaling pathway (GO:0030520)2.80231754
108ncRNA processing (GO:0034470)2.78972884
109mucosal-associated lymphoid tissue development (GO:0048537)2.78637431
110Peyers patch development (GO:0048541)2.78637431
111termination of RNA polymerase III transcription (GO:0006386)2.77913709
112transcription elongation from RNA polymerase III promoter (GO:0006385)2.77913709
113negative regulation of DNA-templated transcription, elongation (GO:0032785)2.77244808
114pentose-phosphate shunt (GO:0006098)2.73253730
115negative regulation of cell size (GO:0045792)2.73163847
116protein retention in ER lumen (GO:0006621)2.71701861
117positive thymic T cell selection (GO:0045059)2.71090434
118snRNA metabolic process (GO:0016073)2.70831658
119COPI coating of Golgi vesicle (GO:0048205)2.70672914
120Golgi transport vesicle coating (GO:0048200)2.70672914
121mismatch repair (GO:0006298)2.69797366
122negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69365691
123pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68298309
124negative regulation of granulocyte differentiation (GO:0030853)2.67554542
125regulation of type I interferon-mediated signaling pathway (GO:0060338)2.66429771
126tRNA modification (GO:0006400)2.65724082
127negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.65643083
128somatic diversification of immune receptors via somatic mutation (GO:0002566)2.65404536
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.65404536
130ncRNA metabolic process (GO:0034660)2.64818932
131iron-sulfur cluster assembly (GO:0016226)2.64139560
132metallo-sulfur cluster assembly (GO:0031163)2.64139560
133DNA-dependent DNA replication (GO:0006261)2.64041534
134snRNA processing (GO:0016180)2.63340230
135kinetochore organization (GO:0051383)2.62142341
136regulation of protein heterodimerization activity (GO:0043497)2.61634338
137apoptotic process involved in morphogenesis (GO:0060561)2.61116161
138poly(A)+ mRNA export from nucleus (GO:0016973)2.60197552
139pentose metabolic process (GO:0019321)2.60187209
140protein-DNA complex disassembly (GO:0032986)2.56748760
141nucleosome disassembly (GO:0006337)2.56748760
142modulation by symbiont of host cellular process (GO:0044068)2.54264025
143positive regulation of B cell differentiation (GO:0045579)2.51772839
144retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51023092
145negative regulation of myeloid cell apoptotic process (GO:0033033)2.51022302
146thymic T cell selection (GO:0045061)2.49998234
147actin nucleation (GO:0045010)2.49255693
148maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.48898344
149negative regulation of B cell apoptotic process (GO:0002903)2.47727856
150pinocytosis (GO:0006907)2.47397224
151glycosphingolipid catabolic process (GO:0046479)2.47292384
1523-UTR-mediated mRNA stabilization (GO:0070935)2.46114951
153N-acetylneuraminate metabolic process (GO:0006054)2.44198403
154histone arginine methylation (GO:0034969)2.41060422
155peptidyl-arginine methylation (GO:0018216)2.40576019
156peptidyl-arginine N-methylation (GO:0035246)2.40576019
157positive regulation by symbiont of host defense response (GO:0052509)2.40332046
158modulation by symbiont of host defense response (GO:0052031)2.40332046
159modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.40332046
160modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.40332046
161positive regulation by organism of defense response of other organism involved in symbiotic interact2.40332046
162modulation by symbiont of host immune response (GO:0052553)2.40332046
163regulation of gamma-delta T cell activation (GO:0046643)2.39395816
164dosage compensation (GO:0007549)2.39140967
165regulation of gamma-delta T cell differentiation (GO:0045586)2.38558701
166regulation of mast cell degranulation (GO:0043304)2.38389023
167histone H4 deacetylation (GO:0070933)2.36949193
168regulation of histone H3-K27 methylation (GO:0061085)2.35973426
169pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.34592298
170regulation of superoxide anion generation (GO:0032928)2.34348223
171amino sugar catabolic process (GO:0046348)2.34317044
172nucleotide salvage (GO:0043173)2.32526767
173glucose catabolic process (GO:0006007)2.29214903
174antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.28281854
175positive regulation of receptor biosynthetic process (GO:0010870)2.28052160
176pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.27651324
177pyrimidine nucleotide catabolic process (GO:0006244)2.26643497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.77739084
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.04830101
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93388737
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06263752
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.91748874
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.85844403
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82544050
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79796766
9* ETS1_20019798_ChIP-Seq_JURKAT_Human2.78789354
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.78506159
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.76785634
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75272630
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68506582
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.67993574
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67654396
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60875477
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52420608
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46388234
19LXR_22292898_ChIP-Seq_THP-1_Human2.45581429
20* XRN2_22483619_ChIP-Seq_HELA_Human2.43752923
21MYC_22102868_ChIP-Seq_BL_Human2.38162040
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35718475
23VDR_23849224_ChIP-Seq_CD4+_Human2.29659678
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27688729
25CIITA_25753668_ChIP-Seq_RAJI_Human2.23290778
26* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.18535382
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14890048
28FOXP3_21729870_ChIP-Seq_TREG_Human2.06994776
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05191296
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99646913
31* VDR_21846776_ChIP-Seq_THP-1_Human1.97794533
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.96279178
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94900158
34* DCP1A_22483619_ChIP-Seq_HELA_Human1.93782552
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91962723
36* GABP_19822575_ChIP-Seq_HepG2_Human1.88228685
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87993192
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87218570
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87192961
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86047664
41* TTF2_22483619_ChIP-Seq_HELA_Human1.85630466
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81762167
43* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79868076
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.78864989
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77490499
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.76731495
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76498966
48P68_20966046_ChIP-Seq_HELA_Human1.75809649
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73129393
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69536409
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68490746
52KDM2B_26808549_Chip-Seq_DND41_Human1.66673053
53RACK7_27058665_Chip-Seq_MCF-7_Human1.65164634
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.64307377
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64209480
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.59226917
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57861290
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57231507
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54721523
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53605864
61* NCOR1_26117541_ChIP-Seq_K562_Human1.53239600
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.53016389
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.52820513
64SCL_19346495_ChIP-Seq_HPC-7_Human1.51319328
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.50603346
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.49429183
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49288324
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48950333
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48225652
70* SPI1_23547873_ChIP-Seq_NB4_Human1.47764001
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.47402175
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47357700
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47193006
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46352533
75BCL6_27268052_Chip-Seq_Bcells_Human1.46062078
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44786174
77BCOR_27268052_Chip-Seq_Bcells_Human1.42414430
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41850344
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41636199
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40944806
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39697109
82ELK1_19687146_ChIP-ChIP_HELA_Human1.38314243
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38158185
84AR_21909140_ChIP-Seq_LNCAP_Human1.36516779
85ZNF263_19887448_ChIP-Seq_K562_Human1.33688625
86* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.32373810
87KDM5A_27292631_Chip-Seq_BREAST_Human1.31175585
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30827687
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30072109
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30008374
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26818946
92SMC4_20622854_ChIP-Seq_HELA_Human1.26431248
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25036508
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24921408
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22337137
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21583995
97CTCF_26484167_Chip-Seq_Bcells_Mouse1.21195195
98TFEB_21752829_ChIP-Seq_HELA_Human1.21165273
99BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18567977
100PHF8_20622854_ChIP-Seq_HELA_Human1.18284485
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.18204154
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17967390
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17426307
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15088155
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14930847
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14689995
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14577910
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14292607
109TP63_19390658_ChIP-ChIP_HaCaT_Human1.14231196
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13347090
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13304125
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13041157
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12692728
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09791844
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09568437
116* FOXP1_21924763_ChIP-Seq_HESCs_Human1.08914674
117E2F1_20622854_ChIP-Seq_HELA_Human1.08452153
118CTCF_21964334_Chip-Seq_Bcells_Human1.08361430
119NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08200747
120IRF8_22096565_ChIP-ChIP_GC-B_Human1.07799566
121UTX_26944678_Chip-Seq_JUKART_Human1.07747596
122KDM2B_26808549_Chip-Seq_K562_Human1.07424499
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06912476
124KDM2B_26808549_Chip-Seq_JURKAT_Human1.06887780
125GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06773925
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06161907
127YY1_22570637_ChIP-Seq_MALME-3M_Human1.06073767
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05616964
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05265865
130CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04750700
131MAF_26560356_Chip-Seq_TH1_Human1.04705433
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04299123
133CREB1_26743006_Chip-Seq_LNCaP_Human1.04189080
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03825048
135VDR_24763502_ChIP-Seq_THP-1_Human1.03375446
136* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99154380
137MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98659413
138KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98319481
139RUNX1_22412390_ChIP-Seq_EML_Mouse0.98144108
140BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95464546
141MYC_18940864_ChIP-ChIP_HL60_Human0.95436355
142MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94222872
143MAF_26560356_Chip-Seq_TH2_Human0.92332464
144* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91789966
145* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91589156
146MYB_26560356_Chip-Seq_TH2_Human0.89849848
147PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87081967
148MYB_26560356_Chip-Seq_TH1_Human0.86863550
149* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85152001
150ELK1_22589737_ChIP-Seq_MCF10A_Human0.84083758
151* TCF7_22412390_ChIP-Seq_EML_Mouse0.83696814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.57561502
2MP0010094_abnormal_chromosome_stability4.02687460
3MP0004957_abnormal_blastocyst_morpholog3.66126928
4MP0002396_abnormal_hematopoietic_system3.64763873
5MP0005451_abnormal_body_composition3.45339734
6MP0003111_abnormal_nucleus_morphology3.45226711
7MP0003077_abnormal_cell_cycle3.28411176
8MP0008057_abnormal_DNA_replication2.97947045
9MP0008058_abnormal_DNA_repair2.78594082
10MP0003806_abnormal_nucleotide_metabolis2.76429669
11MP0008007_abnormal_cellular_replicative2.60447265
12MP0005174_abnormal_tail_pigmentation2.56623098
13MP0003303_peritoneal_inflammation2.56139447
14MP0000678_abnormal_parathyroid_gland2.52289289
15MP0000490_abnormal_crypts_of2.30913431
16MP0004808_abnormal_hematopoietic_stem2.24990450
17MP0008932_abnormal_embryonic_tissue2.20444033
18MP0003763_abnormal_thymus_physiology2.14703764
19MP0008260_abnormal_autophagy2.13773615
20MP0005075_abnormal_melanosome_morpholog2.07225712
21MP0002398_abnormal_bone_marrow2.03672234
22MP0001835_abnormal_antigen_presentation1.97223603
23MP0009333_abnormal_splenocyte_physiolog1.93511785
24MP0003705_abnormal_hypodermis_morpholog1.90008688
25MP0006054_spinal_hemorrhage1.86784362
26MP0000685_abnormal_immune_system1.86644750
27MP0000703_abnormal_thymus_morphology1.81052605
28MP0002722_abnormal_immune_system1.78251709
29MP0004185_abnormal_adipocyte_glucose1.77186963
30MP0000689_abnormal_spleen_morphology1.73406794
31MP0000350_abnormal_cell_proliferation1.70399204
32MP0001800_abnormal_humoral_immune1.66089103
33MP0001730_embryonic_growth_arrest1.64136994
34MP0000465_gastrointestinal_hemorrhage1.63455890
35MP0001545_abnormal_hematopoietic_system1.60077720
36MP0005397_hematopoietic_system_phenotyp1.60077720
37MP0003786_premature_aging1.59903550
38MP0002429_abnormal_blood_cell1.59222454
39MP0005671_abnormal_response_to1.58622230
40MP0001849_ear_inflammation1.57048257
41MP0000716_abnormal_immune_system1.56661753
42MP0002095_abnormal_skin_pigmentation1.55601508
43MP0002019_abnormal_tumor_incidence1.55311977
44MP0002249_abnormal_larynx_morphology1.54378795
45MP0000313_abnormal_cell_death1.51457532
46MP0000681_abnormal_thyroid_gland1.51265232
47MP0010030_abnormal_orbit_morphology1.50624413
48MP0002420_abnormal_adaptive_immunity1.50392031
49MP0002452_abnormal_antigen_presenting1.49509125
50MP0009379_abnormal_foot_pigmentation1.48840716
51MP0002877_abnormal_melanocyte_morpholog1.48190144
52MP0001819_abnormal_immune_cell1.47627028
53MP0005076_abnormal_cell_differentiation1.46614674
54MP0001873_stomach_inflammation1.46420558
55MP0000015_abnormal_ear_pigmentation1.41205927
56MP0003191_abnormal_cellular_cholesterol1.41023909
57MP0004947_skin_inflammation1.36973162
58MP0002080_prenatal_lethality1.34308876
59MP0005666_abnormal_adipose_tissue1.34208376
60MP0002166_altered_tumor_susceptibility1.33985183
61MP0003453_abnormal_keratinocyte_physiol1.33172078
62MP0003866_abnormal_defecation1.32862721
63MP0004858_abnormal_nervous_system1.31550039
64MP0002723_abnormal_immune_serum1.31314883
65MP0010307_abnormal_tumor_latency1.30427557
66MP0001853_heart_inflammation1.26751560
67MP0003656_abnormal_erythrocyte_physiolo1.25376425
68MP0003172_abnormal_lysosome_physiology1.24766731
69MP0003123_paternal_imprinting1.24552938
70MP0008877_abnormal_DNA_methylation1.21342879
71MP0003329_amyloid_beta_deposits1.18328899
72MP0002148_abnormal_hypersensitivity_rea1.17528377
73MP0003300_gastrointestinal_ulcer1.16196739
74MP0005025_abnormal_response_to1.15108950
75MP0001697_abnormal_embryo_size1.12990965
76MP0005501_abnormal_skin_physiology1.12027509
77MP0000003_abnormal_adipose_tissue1.11687494
78MP0010352_gastrointestinal_tract_polyps1.10545482
79MP0005464_abnormal_platelet_physiology1.09966760
80MP0005375_adipose_tissue_phenotype1.09260442
81MP0001661_extended_life_span1.09169425
82MP0005000_abnormal_immune_tolerance1.07848547
83MP0002405_respiratory_system_inflammati1.04314940
84MP0002132_abnormal_respiratory_system1.04238998
85MP0006292_abnormal_olfactory_placode1.04046470
86MP0009840_abnormal_foam_cell1.01851207
87MP0003567_abnormal_fetal_cardiomyocyte0.99271813
88MP0005380_embryogenesis_phenotype0.99204090
89MP0001672_abnormal_embryogenesis/_devel0.99204090
90MP0003121_genomic_imprinting0.98444770
91MP0002102_abnormal_ear_morphology0.97195589
92MP0004381_abnormal_hair_follicle0.96982719
93MP0004147_increased_porphyrin_level0.96458974
94MP0008469_abnormal_protein_level0.93477380
95MP0009278_abnormal_bone_marrow0.93448869
96MP0009785_altered_susceptibility_to0.92705229
97MP0002085_abnormal_embryonic_tissue0.92592116
98MP0000858_altered_metastatic_potential0.92460188
99MP0001845_abnormal_inflammatory_respons0.91991909
100MP0001790_abnormal_immune_system0.90836646
101MP0005387_immune_system_phenotype0.90836646
102MP0003984_embryonic_growth_retardation0.90224295
103MP0000604_amyloidosis0.88940266
104MP0010155_abnormal_intestine_physiology0.87572429
105MP0000747_muscle_weakness0.87571197
106MP0009931_abnormal_skin_appearance0.87039893
107MP0006036_abnormal_mitochondrial_physio0.86516465
108MP0002075_abnormal_coat/hair_pigmentati0.86458641
109MP0002088_abnormal_embryonic_growth/wei0.86120697
110MP0003436_decreased_susceptibility_to0.85754598
111MP0004233_abnormal_muscle_weight0.84803439
112MP0002419_abnormal_innate_immunity0.84299688
113MP0002970_abnormal_white_adipose0.84173105
114MP0005670_abnormal_white_adipose0.83790105
115MP0002006_tumorigenesis0.83636333
116MP0000477_abnormal_intestine_morphology0.79749088
117MP0005310_abnormal_salivary_gland0.79041041
118MP0005171_absent_coat_pigmentation0.78732129
119MP0002086_abnormal_extraembryonic_tissu0.78202768
120MP0001293_anophthalmia0.77563361
121MP0000343_altered_response_to0.77251157
122MP0000358_abnormal_cell_content/0.76504354
123MP0002084_abnormal_developmental_patter0.75608225
124MP0000371_diluted_coat_color0.75486784
125MP0002210_abnormal_sex_determination0.74929204
126MP0001986_abnormal_taste_sensitivity0.74545741
127MP0000609_abnormal_liver_physiology0.74428019
128MP0001764_abnormal_homeostasis0.73863789
129MP0003315_abnormal_perineum_morphology0.73625056
130MP0001145_abnormal_male_reproductive0.72454973
131MP0005384_cellular_phenotype0.72246801
132MP0004197_abnormal_fetal_growth/weight/0.71942017
133MP0005058_abnormal_lysosome_morphology0.71216650
134MP0001533_abnormal_skeleton_physiology0.71175069
135MP0005621_abnormal_cell_physiology0.67595387
136MP0000049_abnormal_middle_ear0.63746450
137MP0006035_abnormal_mitochondrial_morpho0.63209563
138MP0001186_pigmentation_phenotype0.62719982

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.32093054
2Abnormal number of erythroid precursors (HP:0012131)6.05018248
3Reticulocytopenia (HP:0001896)5.83531074
4Pallor (HP:0000980)4.48206203
5Aplastic anemia (HP:0001915)4.16574107
6Thrombocytosis (HP:0001894)3.94961409
7Hypertensive crisis (HP:0100735)3.83646510
8Truncus arteriosus (HP:0001660)3.81890074
9Macrocytic anemia (HP:0001972)3.66243725
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.41714459
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.41714459
12IgM deficiency (HP:0002850)3.41007626
13Chronic obstructive pulmonary disease (HP:0006510)3.39876437
14Obstructive lung disease (HP:0006536)3.39876437
15Colon cancer (HP:0003003)3.30861267
16Seborrheic dermatitis (HP:0001051)3.23509895
17Birth length less than 3rd percentile (HP:0003561)3.22777945
18Abnormality of the heme biosynthetic pathway (HP:0010472)3.19598653
19Hyperthyroidism (HP:0000836)3.15693002
20Oral leukoplakia (HP:0002745)3.02208269
21Colitis (HP:0002583)2.92821419
22Reticulocytosis (HP:0001923)2.92408227
23Selective tooth agenesis (HP:0001592)2.88964498
24Myelodysplasia (HP:0002863)2.81867506
25Degeneration of anterior horn cells (HP:0002398)2.79230297
26Abnormality of the anterior horn cell (HP:0006802)2.79230297
27Cholecystitis (HP:0001082)2.79200461
28Abnormal gallbladder physiology (HP:0012438)2.79200461
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75401168
3011 pairs of ribs (HP:0000878)2.73768159
31Agnosia (HP:0010524)2.63145585
32Elevated erythrocyte sedimentation rate (HP:0003565)2.62653848
33Increased serum ferritin (HP:0003281)2.61980698
34Chronic otitis media (HP:0000389)2.60809616
35Type I transferrin isoform profile (HP:0003642)2.59564721
36Hyperacusis (HP:0010780)2.58511395
37Recurrent abscess formation (HP:0002722)2.56055409
38Ulnar bowing (HP:0003031)2.54824885
39Broad distal phalanx of finger (HP:0009836)2.54800846
40Microretrognathia (HP:0000308)2.54461827
41Abnormal large intestine physiology (HP:0012700)2.52310963
42Lymphoma (HP:0002665)2.52266802
43Abnormality of liposaccharide metabolism (HP:0010968)2.51530979
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.51530979
45Abnormality of glycolipid metabolism (HP:0010969)2.51530979
46Eczematoid dermatitis (HP:0000976)2.50036608
47Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.49505631
48Recurrent bacterial skin infections (HP:0005406)2.49203975
49Testicular atrophy (HP:0000029)2.47647596
50Petechiae (HP:0000967)2.47444917
51Bone marrow hypocellularity (HP:0005528)2.46430240
52Rough bone trabeculation (HP:0100670)2.45326486
53Poikiloderma (HP:0001029)2.44903433
54Bowel incontinence (HP:0002607)2.44739638
55Abnormality of the thoracic spine (HP:0100711)2.44455799
56Absent thumb (HP:0009777)2.43292935
57Ragged-red muscle fibers (HP:0003200)2.42776091
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42114121
59Atelectasis (HP:0100750)2.41787525
60Premature graying of hair (HP:0002216)2.40426546
61Pancytopenia (HP:0001876)2.39702395
62Stridor (HP:0010307)2.39253579
63Dysostosis multiplex (HP:0000943)2.37411560
64Chromsome breakage (HP:0040012)2.35391534
65Basal cell carcinoma (HP:0002671)2.34749762
66Annular pancreas (HP:0001734)2.34129712
67Increased cerebral lipofuscin (HP:0011813)2.29428198
68Myopathic facies (HP:0002058)2.29137553
69Abnormality of T cell physiology (HP:0011840)2.27633072
70Patellar aplasia (HP:0006443)2.22838692
71Abnormality of the preputium (HP:0100587)2.21607511
72Hemorrhage of the eye (HP:0011885)2.21539329
73Asplenia (HP:0001746)2.19354002
74Abnormal number of incisors (HP:0011064)2.19232837
75Abnormality of the tricuspid valve (HP:0001702)2.18488662
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18038002
77Abnormality of DNA repair (HP:0003254)2.17717322
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17353061
79Abnormal protein N-linked glycosylation (HP:0012347)2.17353061
80Abnormal protein glycosylation (HP:0012346)2.17353061
81Abnormal glycosylation (HP:0012345)2.17353061
82Hepatosplenomegaly (HP:0001433)2.16450285
83Reduced antithrombin III activity (HP:0001976)2.14955480
84Aplasia/Hypoplasia of the patella (HP:0006498)2.12542791
85Microvesicular hepatic steatosis (HP:0001414)2.12169161
86Abnormality of B cell number (HP:0010975)2.11119078
87B lymphocytopenia (HP:0010976)2.11119078
88Purpura (HP:0000979)2.10681309
89Hypoplasia of the radius (HP:0002984)2.10223488
90Cholelithiasis (HP:0001081)2.10110624
91Medulloblastoma (HP:0002885)2.10081277
92Neoplasm of the pancreas (HP:0002894)2.09928420
93Recurrent bronchitis (HP:0002837)2.09781355
94Thoracic kyphosis (HP:0002942)2.09363293
95Aplasia/Hypoplasia of the spleen (HP:0010451)2.08477117
96Vertebral compression fractures (HP:0002953)2.07388325
97Abnormality of chromosome stability (HP:0003220)2.06890610
98Breast hypoplasia (HP:0003187)2.06328041
99Abnormality of the ileum (HP:0001549)2.06074222
100Cleft eyelid (HP:0000625)2.05858738
101Increased neuronal autofluorescent lipopigment (HP:0002074)2.05784206
102Fatigue (HP:0012378)2.05744425
103Achilles tendon contracture (HP:0001771)2.04993444
104Ependymoma (HP:0002888)2.04898841
105Meckel diverticulum (HP:0002245)2.04664933
106Mediastinal lymphadenopathy (HP:0100721)2.04315602
107Panhypogammaglobulinemia (HP:0003139)2.04111207
108Abnormality of reticulocytes (HP:0004312)2.03951191
109Abnormality of macrophages (HP:0004311)2.02531568
110Acute lymphatic leukemia (HP:0006721)2.02302849
111Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00760401
112Nonimmune hydrops fetalis (HP:0001790)1.99845714
113Entropion (HP:0000621)1.99600192
114Cellulitis (HP:0100658)1.99509251
115Duodenal stenosis (HP:0100867)1.99105952
116Small intestinal stenosis (HP:0012848)1.99105952
117Cerebral hypomyelination (HP:0006808)1.96114007
118Thin bony cortex (HP:0002753)1.95974620
119Aplasia/Hypoplasia of the uvula (HP:0010293)1.95973105
120Progressive muscle weakness (HP:0003323)1.95837292
121Trismus (HP:0000211)1.95586114
122Hypertriglyceridemia (HP:0002155)1.95567986
123Squamous cell carcinoma (HP:0002860)1.95494699
124Hypoparathyroidism (HP:0000829)1.93749881
125Abnormality of cells of the lymphoid lineage (HP:0012140)1.93682902
126Recurrent viral infections (HP:0004429)1.93071721
127Abnormality of T cells (HP:0002843)1.92014777
128Leukopenia (HP:0001882)1.91798095
129Poor head control (HP:0002421)1.91398992
130Cellular immunodeficiency (HP:0005374)1.90531365
131Premature skin wrinkling (HP:0100678)1.90230448
132Inflammation of the large intestine (HP:0002037)1.89466638
133Polycythemia (HP:0001901)1.88769288
134Slender long bone (HP:0003100)1.88499020
135Abnormal delayed hypersensitivity skin test (HP:0002963)1.88322477
136Depressed nasal ridge (HP:0000457)1.87025692
137Distal lower limb amyotrophy (HP:0008944)1.85044320
138Long palpebral fissure (HP:0000637)1.84854856
139Slow saccadic eye movements (HP:0000514)1.84285393
140Increased IgE level (HP:0003212)1.83986092
141Lymphopenia (HP:0001888)1.83945876
142Atrophy/Degeneration involving motor neurons (HP:0007373)1.83876306
143Patellar dislocation (HP:0002999)1.83798660
144Gastrointestinal inflammation (HP:0004386)1.83153660
145Disproportionate tall stature (HP:0001519)1.82712951
146Severe visual impairment (HP:0001141)1.81821790
147Abnormality of the columella (HP:0009929)1.81798428
148Abnormality of the fingertips (HP:0001211)1.81737503
149Meningitis (HP:0001287)1.80747302
150Triphalangeal thumb (HP:0001199)1.80003961
151Interstitial pulmonary disease (HP:0006530)1.78812669
152Increased serum lactate (HP:0002151)1.78806779
153Gastrointestinal dysmotility (HP:0002579)1.78793464
154Amaurosis fugax (HP:0100576)1.78709586
155Recurrent fungal infections (HP:0002841)1.78282067
156Volvulus (HP:0002580)1.78274434
157Aplasia/Hypoplasia of the thymus (HP:0010515)1.78039353
158Prominent nose (HP:0000448)1.76705865
159Progressive external ophthalmoplegia (HP:0000590)1.76705749
160Hepatocellular necrosis (HP:0001404)1.76480255
161Prolonged neonatal jaundice (HP:0006579)1.76115486
162Glossoptosis (HP:0000162)1.76021321
163Prolonged bleeding time (HP:0003010)1.75910291
164Abnormality of iron homeostasis (HP:0011031)1.75272712
165Abnormality of the gallbladder (HP:0005264)1.73402119
166Joint stiffness (HP:0001387)1.73067626
167Vaginal fistula (HP:0004320)1.72079714
168Biconcave vertebral bodies (HP:0004586)1.71432910
169Abnormality of the Achilles tendon (HP:0005109)1.70908018
170Loss of speech (HP:0002371)1.70559937
171Abnormality of lateral ventricle (HP:0030047)1.69282481
172Centrally nucleated skeletal muscle fibers (HP:0003687)1.69135226
173Increased muscle lipid content (HP:0009058)1.68778616
174Broad face (HP:0000283)1.64965821
175Neuronal loss in central nervous system (HP:0002529)1.64640892
176Flared metaphyses (HP:0003015)1.63587975
177Abnormality of the nasal mucosa (HP:0000433)1.63383327
178Intestinal fistula (HP:0100819)1.62632723
179Dysautonomia (HP:0002459)1.62529447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.84110271
2EIF2AK13.81950028
3STK163.81573612
4TLK13.67300943
5IRAK33.22538269
6SMG13.21706126
7WEE12.99712859
8MAP4K12.91020641
9PRPF4B2.85365826
10CDC72.69733754
11NME22.68288170
12FLT32.14512381
13EEF2K2.05827184
14ICK2.05641174
15VRK12.01627690
16NEK22.00275557
17PASK1.91238573
18RIPK41.88291080
19DYRK31.85926919
20SIK11.82873672
21SRPK11.81259097
22ACVR1B1.74107427
23TSSK61.73585979
24TESK21.68869809
25CDK121.66945312
26BRSK21.64718848
27SCYL21.61210519
28RPS6KB21.60824915
29MAP3K101.58773135
30CDK191.53658023
31BTK1.50724947
32MAP2K31.47132340
33EIF2AK31.46591282
34TAOK21.44061960
35ATR1.43611713
36MAP3K131.40041474
37PIM21.39635272
38CDK41.36313477
39MKNK11.31807858
40KIT1.31500591
41LRRK21.31434570
42ZAP701.30769393
43RPS6KA41.29048067
44TAOK31.24799220
45MAPK111.24429862
46TGFBR11.23836901
47CDK71.21598558
48TNK21.17270569
49KSR21.17262371
50CSF1R1.17205846
51CCNB11.14203453
52BLK1.13825628
53TEC1.12951653
54AURKB1.11659779
55ARAF1.10716805
56STK101.07070805
57PDPK11.06502276
58PLK11.05554178
59MAP3K141.04707437
60PKN21.00418693
61MARK20.99879630
62MKNK20.98121182
63PAK40.97347018
64MAP3K80.97251502
65CLK10.97187920
66CAMKK20.97020023
67GRK60.96613423
68MAP3K110.95581703
69TESK10.95028190
70ERN10.93771198
71TTK0.93540990
72MAP3K10.92634313
73SYK0.91497166
74PRKD20.91004913
75IRAK20.88115606
76KDR0.87643378
77MAPK120.83770220
78PRKD30.83609500
79CDK80.83315085
80MAP3K30.81121903
81PIM10.81082066
82CHEK20.80527799
83MTOR0.79813476
84BRSK10.78511514
85MAPK150.77988517
86RPS6KC10.73881928
87RPS6KL10.73881928
88BCKDK0.73847229
89AURKA0.71504191
90MATK0.69013160
91TAOK10.68681077
92PTK60.68117348
93CDC42BPA0.68062476
94MAP2K20.67905588
95JAK30.67159921
96PDK10.66964180
97CHEK10.66416234
98BRD40.66344191
99BMX0.63452469
100NME10.63347211
101FGFR40.62581505
102HIPK20.61825705
103LYN0.59488796
104TTN0.59292538
105MAPKAPK30.59278705
106CSK0.58940183
107BRAF0.58705806
108MAP2K60.57181969
109STK40.56346300
110RPS6KA60.56221776
111IRAK40.55555505
112CDK20.55530258
113PLK40.55065047
114EPHB10.54932423
115CAMK1D0.54762056
116CSNK2A20.54382967
117RPS6KA20.54307274
118VRK20.51979612
119HCK0.51811124
120FES0.51674226
121TRIB30.50714592
122IKBKE0.50281165
123MAP3K70.48325691
124ILK0.47921904
125CSNK2A10.46912000
126TXK0.46023856
127SIK20.45334927
128TYK20.45199002
129LCK0.44790743
130PAK10.44267198
131CDK60.43129470
132TGFBR20.42428862
133DAPK10.41628885
134ZAK0.41272839
135RPS6KA50.40004390
136MAPK70.38718512
137DYRK1B0.38554978
138ATM0.37610449
139JAK20.36705364
140UHMK10.36630543
141PLK30.33597236
142SIK30.33092051
143PRKCI0.32437044
144TBK10.31994429
145CDK10.31868305
146AKT20.31497630
147IKBKB0.29859831
148MAP3K120.29309596
149RAF10.25726773

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.29602744
2Ribosome_Homo sapiens_hsa030104.66579718
3Mismatch repair_Homo sapiens_hsa034304.35866544
4Base excision repair_Homo sapiens_hsa034103.31879830
5Spliceosome_Homo sapiens_hsa030403.30524513
6Homologous recombination_Homo sapiens_hsa034402.92172177
7RNA polymerase_Homo sapiens_hsa030202.89247545
8Pyrimidine metabolism_Homo sapiens_hsa002402.70216349
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65387527
10Nucleotide excision repair_Homo sapiens_hsa034202.59689384
11Proteasome_Homo sapiens_hsa030502.48988551
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32341076
13RNA transport_Homo sapiens_hsa030132.30865740
14Cell cycle_Homo sapiens_hsa041102.19259843
15Fanconi anemia pathway_Homo sapiens_hsa034602.06311183
16One carbon pool by folate_Homo sapiens_hsa006701.99537020
17Non-homologous end-joining_Homo sapiens_hsa034501.80944069
18Protein export_Homo sapiens_hsa030601.65469874
19RNA degradation_Homo sapiens_hsa030181.63670099
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53306334
21Primary immunodeficiency_Homo sapiens_hsa053401.38665344
22Purine metabolism_Homo sapiens_hsa002301.37611884
23mRNA surveillance pathway_Homo sapiens_hsa030151.33105374
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32572898
25VEGF signaling pathway_Homo sapiens_hsa043701.31901133
26Sulfur relay system_Homo sapiens_hsa041221.27633454
27p53 signaling pathway_Homo sapiens_hsa041151.27127148
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26943331
29Systemic lupus erythematosus_Homo sapiens_hsa053221.26206112
30Antigen processing and presentation_Homo sapiens_hsa046121.23025759
31N-Glycan biosynthesis_Homo sapiens_hsa005101.20831882
32Epstein-Barr virus infection_Homo sapiens_hsa051691.19793437
33Basal transcription factors_Homo sapiens_hsa030221.18413785
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09849835
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.08869338
36Herpes simplex infection_Homo sapiens_hsa051681.05160149
37mTOR signaling pathway_Homo sapiens_hsa041500.95052514
38Folate biosynthesis_Homo sapiens_hsa007900.89056289
39Other glycan degradation_Homo sapiens_hsa005110.88496929
40Viral carcinogenesis_Homo sapiens_hsa052030.88492548
41B cell receptor signaling pathway_Homo sapiens_hsa046620.87545280
42Toxoplasmosis_Homo sapiens_hsa051450.86574478
43Tuberculosis_Homo sapiens_hsa051520.85815611
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85432191
45Carbon metabolism_Homo sapiens_hsa012000.84108633
46Pentose phosphate pathway_Homo sapiens_hsa000300.83130271
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82088842
48TNF signaling pathway_Homo sapiens_hsa046680.82071546
49Hepatitis C_Homo sapiens_hsa051600.81441186
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.79061162
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.78621759
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77635384
53Prion diseases_Homo sapiens_hsa050200.73906578
54HTLV-I infection_Homo sapiens_hsa051660.73233561
55Hematopoietic cell lineage_Homo sapiens_hsa046400.70855944
56Selenocompound metabolism_Homo sapiens_hsa004500.70725554
57Measles_Homo sapiens_hsa051620.70194409
58Allograft rejection_Homo sapiens_hsa053300.69890903
59Alcoholism_Homo sapiens_hsa050340.69492378
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67101783
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66916551
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65666836
63Shigellosis_Homo sapiens_hsa051310.63580952
64Insulin signaling pathway_Homo sapiens_hsa049100.62119638
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.60962327
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.60893890
67Viral myocarditis_Homo sapiens_hsa054160.58760170
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57471382
69Autoimmune thyroid disease_Homo sapiens_hsa053200.57117683
70Glioma_Homo sapiens_hsa052140.56021264
71Prolactin signaling pathway_Homo sapiens_hsa049170.55549019
72Chronic myeloid leukemia_Homo sapiens_hsa052200.55099357
73Hepatitis B_Homo sapiens_hsa051610.54811223
74Notch signaling pathway_Homo sapiens_hsa043300.53888498
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53400796
76Apoptosis_Homo sapiens_hsa042100.53213156
77Acute myeloid leukemia_Homo sapiens_hsa052210.52980151
78Staphylococcus aureus infection_Homo sapiens_hsa051500.52474532
79Asthma_Homo sapiens_hsa053100.52034534
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50171605
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49759930
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.49589944
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47704508
84Salmonella infection_Homo sapiens_hsa051320.47250348
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.47109149
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46697740
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46344994
88Renal cell carcinoma_Homo sapiens_hsa052110.46007995
89Leishmaniasis_Homo sapiens_hsa051400.45663295
90Legionellosis_Homo sapiens_hsa051340.45231738
91Insulin resistance_Homo sapiens_hsa049310.45030135
92ErbB signaling pathway_Homo sapiens_hsa040120.44900128
93Thyroid cancer_Homo sapiens_hsa052160.44549809
94Oocyte meiosis_Homo sapiens_hsa041140.43486937
95Small cell lung cancer_Homo sapiens_hsa052220.42739524
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42508151
97Inositol phosphate metabolism_Homo sapiens_hsa005620.41842338
98Endometrial cancer_Homo sapiens_hsa052130.41595540
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.40140431
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39758472
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39214626
102Influenza A_Homo sapiens_hsa051640.38465955
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37812575
104Colorectal cancer_Homo sapiens_hsa052100.36979187
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36719079
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36673418
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.35814855
108Non-small cell lung cancer_Homo sapiens_hsa052230.35752132
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34869148
110Biosynthesis of amino acids_Homo sapiens_hsa012300.33914639
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31655658
112Huntingtons disease_Homo sapiens_hsa050160.31426062
113Parkinsons disease_Homo sapiens_hsa050120.31379843
114MicroRNAs in cancer_Homo sapiens_hsa052060.27839103
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27363887
116Galactose metabolism_Homo sapiens_hsa000520.26489954
117T cell receptor signaling pathway_Homo sapiens_hsa046600.25792515
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25115530
119Fructose and mannose metabolism_Homo sapiens_hsa000510.25102738
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.24789679
121Platelet activation_Homo sapiens_hsa046110.22259778
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22188780
123Bladder cancer_Homo sapiens_hsa052190.21763593
124Osteoclast differentiation_Homo sapiens_hsa043800.21655105
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.21256822
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.20626661
127Pancreatic cancer_Homo sapiens_hsa052120.18402207
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.18191756
129Regulation of autophagy_Homo sapiens_hsa041400.18075503
130Lysosome_Homo sapiens_hsa041420.17736434
131Pathways in cancer_Homo sapiens_hsa052000.17603514
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16677373
133HIF-1 signaling pathway_Homo sapiens_hsa040660.13947150

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