TRMT2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.60202654
2L-phenylalanine catabolic process (GO:0006559)4.60202654
3aromatic amino acid family catabolic process (GO:0009074)4.44103001
4tryptophan catabolic process (GO:0006569)4.38238545
5indole-containing compound catabolic process (GO:0042436)4.38238545
6indolalkylamine catabolic process (GO:0046218)4.38238545
7fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.36658538
8L-phenylalanine metabolic process (GO:0006558)4.33987053
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.33987053
10fatty acid beta-oxidation (GO:0006635)4.25910224
11negative regulation of cell killing (GO:0031342)4.25704721
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.25704721
13tryptophan metabolic process (GO:0006568)4.24965388
14kynurenine metabolic process (GO:0070189)3.97967145
15glyoxylate metabolic process (GO:0046487)3.96351930
16amino-acid betaine metabolic process (GO:0006577)3.95249278
17fatty acid catabolic process (GO:0009062)3.91695465
18carnitine metabolic process (GO:0009437)3.91632404
19fatty acid oxidation (GO:0019395)3.84382892
20negative T cell selection (GO:0043383)3.79543470
21lipid oxidation (GO:0034440)3.79099934
22peptidyl-histidine modification (GO:0018202)3.77748800
23lysine catabolic process (GO:0006554)3.75512190
24lysine metabolic process (GO:0006553)3.75512190
25negative regulation of T cell mediated immunity (GO:0002710)3.71141855
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.69675179
27negative thymic T cell selection (GO:0045060)3.66384945
28histone H3-K4 trimethylation (GO:0080182)3.65356988
29bile acid biosynthetic process (GO:0006699)3.57248202
30monocarboxylic acid catabolic process (GO:0072329)3.56802256
31positive regulation of granulocyte differentiation (GO:0030854)3.53153110
32hepatocyte apoptotic process (GO:0097284)3.52771141
33fatty acid transmembrane transport (GO:1902001)3.51129579
34ubiquinone biosynthetic process (GO:0006744)3.51096673
35spindle assembly involved in mitosis (GO:0090307)3.51072396
36carnitine shuttle (GO:0006853)3.49242188
37regulation of triglyceride catabolic process (GO:0010896)3.49194398
38high-density lipoprotein particle remodeling (GO:0034375)3.46453702
39short-chain fatty acid metabolic process (GO:0046459)3.45468770
40alpha-linolenic acid metabolic process (GO:0036109)3.41561178
41regulation of nuclear cell cycle DNA replication (GO:0033262)3.41447302
42phospholipid homeostasis (GO:0055091)3.38199871
43branched-chain amino acid catabolic process (GO:0009083)3.37624440
44valine metabolic process (GO:0006573)3.35466710
45indolalkylamine metabolic process (GO:0006586)3.31108792
462-oxoglutarate metabolic process (GO:0006103)3.29901562
47amine catabolic process (GO:0009310)3.29640943
48cellular biogenic amine catabolic process (GO:0042402)3.29640943
49regulation of B cell receptor signaling pathway (GO:0050855)3.28752695
50regulation of gamma-delta T cell differentiation (GO:0045586)3.24090468
51homocysteine metabolic process (GO:0050667)3.22529087
52branched-chain amino acid metabolic process (GO:0009081)3.22309077
53tolerance induction (GO:0002507)3.19721385
54regulation of memory T cell differentiation (GO:0043380)3.18671737
55replication fork processing (GO:0031297)3.17370688
56aromatic amino acid family metabolic process (GO:0009072)3.15978414
57positive regulation of gamma-delta T cell activation (GO:0046645)3.15959494
58phospholipid efflux (GO:0033700)3.14150131
59reverse cholesterol transport (GO:0043691)3.13547210
60urea metabolic process (GO:0019627)3.10543659
61urea cycle (GO:0000050)3.10543659
62peptidyl-threonine dephosphorylation (GO:0035970)3.10239654
63protein-lipid complex remodeling (GO:0034368)3.10100434
64macromolecular complex remodeling (GO:0034367)3.10100434
65plasma lipoprotein particle remodeling (GO:0034369)3.10100434
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06593757
67mitochondrial RNA metabolic process (GO:0000959)3.05741501
68blood coagulation, intrinsic pathway (GO:0007597)3.04738605
69fucose catabolic process (GO:0019317)3.04452616
70L-fucose metabolic process (GO:0042354)3.04452616
71L-fucose catabolic process (GO:0042355)3.04452616
72benzene-containing compound metabolic process (GO:0042537)3.02658860
73microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.01614610
74ubiquinone metabolic process (GO:0006743)3.01478920
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01297931
76NAD biosynthetic process (GO:0009435)3.00601107
77oxaloacetate metabolic process (GO:0006107)3.00491868
78positive regulation of fatty acid beta-oxidation (GO:0032000)2.99968178
79regulation of T cell mediated cytotoxicity (GO:0001914)2.99535704
80bile acid metabolic process (GO:0008206)2.98638114
81peptidyl-lysine trimethylation (GO:0018023)2.98354910
82sulfur amino acid catabolic process (GO:0000098)2.98341496
83behavioral response to nicotine (GO:0035095)2.98248986
84activated T cell proliferation (GO:0050798)2.97858041
85acylglycerol homeostasis (GO:0055090)2.97422772
86triglyceride homeostasis (GO:0070328)2.97422772
87ethanol oxidation (GO:0006069)2.97328632
88drug transmembrane transport (GO:0006855)2.96173655
89viral mRNA export from host cell nucleus (GO:0046784)2.95766869
90carboxylic acid catabolic process (GO:0046395)2.93690378
91organic acid catabolic process (GO:0016054)2.93690378
92regulation of sequestering of triglyceride (GO:0010889)2.93689602
93coenzyme catabolic process (GO:0009109)2.93607092
94protein K11-linked deubiquitination (GO:0035871)2.92644605
95tRNA modification (GO:0006400)2.92605148
96complement activation, alternative pathway (GO:0006957)2.91858112
97tyrosine metabolic process (GO:0006570)2.91517817
98regulation of gamma-delta T cell activation (GO:0046643)2.91088102
99alpha-amino acid catabolic process (GO:1901606)2.89828841
100peptidyl-glutamic acid carboxylation (GO:0017187)2.88738121
101protein carboxylation (GO:0018214)2.88738121
102reciprocal DNA recombination (GO:0035825)2.88332961
103reciprocal meiotic recombination (GO:0007131)2.88332961
104carnitine transmembrane transport (GO:1902603)2.85959621
105cellular ketone body metabolic process (GO:0046950)2.84178905
106snRNA transcription (GO:0009301)2.83667547
107tricarboxylic acid cycle (GO:0006099)2.82206275
108thymic T cell selection (GO:0045061)2.80254432
109response to interleukin-15 (GO:0070672)2.79605446
110tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78977875
111RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78977875
112positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78820395
113cysteine metabolic process (GO:0006534)2.78157065
114establishment of protein localization to Golgi (GO:0072600)2.78001801
115regulation of bile acid biosynthetic process (GO:0070857)2.77709639
116biotin metabolic process (GO:0006768)2.77337263
117negative regulation of lipase activity (GO:0060192)2.77227702
118amino-acid betaine transport (GO:0015838)2.76774487
119carnitine transport (GO:0015879)2.76774487
120nitrogen cycle metabolic process (GO:0071941)2.76621183
121low-density lipoprotein particle remodeling (GO:0034374)2.76139583
122T-helper cell differentiation (GO:0042093)2.75742092
123CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.75742092
124positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75527997
125regulation of centriole replication (GO:0046599)2.74649050
126positive regulation of lipid catabolic process (GO:0050996)2.74596158
127acetyl-CoA metabolic process (GO:0006084)2.74104764
128epithelial cilium movement (GO:0003351)2.73572802
129rRNA catabolic process (GO:0016075)2.73425604
130RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72058385
131positive regulation of fatty acid oxidation (GO:0046321)2.71393273
132xenobiotic catabolic process (GO:0042178)2.71072620
133negative regulation of lymphocyte mediated immunity (GO:0002707)2.70564176
134cellular glucuronidation (GO:0052695)2.70279980
135pyrimidine nucleoside catabolic process (GO:0046135)2.70225261
136cellular amino acid catabolic process (GO:0009063)2.69708001
137positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.69297096
138flavonoid metabolic process (GO:0009812)2.69295654
139alpha-beta T cell differentiation (GO:0046632)2.68797826
140T cell selection (GO:0045058)2.68152366
141response to nitrosative stress (GO:0051409)2.68007585
142pyridine nucleotide biosynthetic process (GO:0019363)2.67477638
143nicotinamide nucleotide biosynthetic process (GO:0019359)2.67477638
144cellular response to interleukin-15 (GO:0071350)2.67351659
145negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.66362478
146regulation of protein activation cascade (GO:2000257)2.65141899
147regulation of cholesterol esterification (GO:0010872)2.64535172
148regulation of sarcomere organization (GO:0060297)2.63299986
149regulation of cholesterol metabolic process (GO:0090181)2.63173792
150aspartate family amino acid catabolic process (GO:0009068)2.62808136
151replicative senescence (GO:0090399)2.62670986
152interkinetic nuclear migration (GO:0022027)2.62398670
153quinone biosynthetic process (GO:1901663)2.61837986
154NAD metabolic process (GO:0019674)2.61196462
155cofactor catabolic process (GO:0051187)2.61026885
156tricarboxylic acid metabolic process (GO:0072350)2.59604589
157negative regulation of DNA-dependent DNA replication (GO:2000104)2.58785906
158antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58139869
159antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.58139869
160histone H3-K4 methylation (GO:0051568)2.58117855
161axoneme assembly (GO:0035082)2.56663106
162T cell differentiation involved in immune response (GO:0002292)2.56599611
163alpha-beta T cell differentiation involved in immune response (GO:0002293)2.56599611
164alpha-beta T cell activation involved in immune response (GO:0002287)2.56599611
165DNA deamination (GO:0045006)2.55046416
166regulation of interleukin-5 production (GO:0032674)2.54505837
167L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54138530
168peptidyl-lysine methylation (GO:0018022)2.51806307
169alpha-beta T cell activation (GO:0046631)2.49433353
170preassembly of GPI anchor in ER membrane (GO:0016254)2.47268200
171mRNA cleavage (GO:0006379)2.45665377
172protein targeting to Golgi (GO:0000042)2.45476846
173negative regulation of adaptive immune response (GO:0002820)2.44713823
174CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.44524783
175regulation of histone H3-K4 methylation (GO:0051569)2.43853017
176negative regulation of cAMP-mediated signaling (GO:0043951)2.43781405
177regulation of defense response to virus by host (GO:0050691)2.42848613
178positive regulation of defense response to virus by host (GO:0002230)2.42050042
179regulation of regulatory T cell differentiation (GO:0045589)2.41692576
180centriole replication (GO:0007099)2.41372907
181cardiovascular system development (GO:0072358)2.41067801
182maintenance of protein location in nucleus (GO:0051457)2.40992542
183protein K63-linked deubiquitination (GO:0070536)2.39867508
184* tRNA processing (GO:0008033)2.39137262
185positive regulation of histone H3-K4 methylation (GO:0051571)2.38283723
186recombinational repair (GO:0000725)2.37521160
187protein K48-linked deubiquitination (GO:0071108)2.36642238
188B cell receptor signaling pathway (GO:0050853)2.36305826
189DNA damage induced protein phosphorylation (GO:0006975)2.35706870
190double-strand break repair via homologous recombination (GO:0000724)2.35674359
191regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.35124076
192DNA methylation involved in gamete generation (GO:0043046)2.33903390
193tRNA methylation (GO:0030488)2.33622939
194cellular response to exogenous dsRNA (GO:0071360)2.32802664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.28736048
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.50204017
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.41585804
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.37215425
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.78255074
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.77304723
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.75515062
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.75105244
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.94945296
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.93995096
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.77649608
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.67552687
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.67548357
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.51419172
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.51057949
16ZNF274_21170338_ChIP-Seq_K562_Hela2.48186549
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.47927581
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45877338
19GATA1_22025678_ChIP-Seq_K562_Human2.39127202
20VDR_23849224_ChIP-Seq_CD4+_Human2.38954947
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.28459771
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.24821205
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15923214
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.15859001
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.13599441
26SCL_19346495_ChIP-Seq_HPC-7_Human2.12492413
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.04063456
28RUNX_20019798_ChIP-Seq_JUKART_Human2.03032889
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01420709
30FOXP3_21729870_ChIP-Seq_TREG_Human2.00704974
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00188120
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.00103318
33KDM5A_27292631_Chip-Seq_BREAST_Human1.93855259
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.92339573
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92285773
36* MYB_26560356_Chip-Seq_TH2_Human1.90574424
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87199118
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84962866
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.82785066
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78737158
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.77124369
42CIITA_25753668_ChIP-Seq_RAJI_Human1.69609181
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64838934
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60844423
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.59006997
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54869963
47ELK1_19687146_ChIP-ChIP_HELA_Human1.53681474
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53529934
49MYB_26560356_Chip-Seq_TH1_Human1.53366272
50GATA3_27048872_Chip-Seq_THYMUS_Human1.53182370
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51636572
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51611823
53* GABP_19822575_ChIP-Seq_HepG2_Human1.50690544
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50647407
55MYC_22102868_ChIP-Seq_BL_Human1.50525046
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49836919
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47226005
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45780236
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45668610
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.45382853
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44986597
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43919203
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41829485
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.41248365
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39284833
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.38191149
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37552435
68ER_23166858_ChIP-Seq_MCF-7_Human1.37363554
69* TP53_22573176_ChIP-Seq_HFKS_Human1.37136447
70SPI1_23547873_ChIP-Seq_NB4_Human1.37028818
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35938809
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33320788
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33264749
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.32951220
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31129680
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30073414
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29977012
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28061633
79VDR_22108803_ChIP-Seq_LS180_Human1.27955821
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27275574
81IGF1R_20145208_ChIP-Seq_DFB_Human1.26747811
82TAF15_26573619_Chip-Seq_HEK293_Human1.26355326
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26231127
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25615784
85GBX2_23144817_ChIP-Seq_PC3_Human1.25408454
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.24114476
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23918190
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22704146
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.20611824
90MAF_26560356_Chip-Seq_TH2_Human1.19032524
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18171584
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.18104119
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17579634
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17444271
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17313803
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15841836
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15528233
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15132194
99HTT_18923047_ChIP-ChIP_STHdh_Human1.14984345
100MAF_26560356_Chip-Seq_TH1_Human1.14471250
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14165381
102STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13129268
103EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12397532
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10852648
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10347801
106DCP1A_22483619_ChIP-Seq_HELA_Human1.10311647
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10196882
108* NOTCH1_21737748_ChIP-Seq_TLL_Human1.09737711
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07051545
110FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06452779
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05799105
112UTX_26944678_Chip-Seq_JUKART_Human1.05102230
113ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05012905
114VDR_24787735_ChIP-Seq_THP-1_Human1.04697399
115TFEB_21752829_ChIP-Seq_HELA_Human1.03278174
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02532156
117GATA1_19941827_ChIP-Seq_MEL_Mouse1.02200438
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.02171840
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01237505
120PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01198130
121P53_22387025_ChIP-Seq_ESCs_Mouse1.01118209
122NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00568312
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00568312
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00234823
125POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99587079
126E2F7_22180533_ChIP-Seq_HELA_Human0.99326268
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99148665
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.98500239
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.98015729
130GATA3_21878914_ChIP-Seq_MCF-7_Human0.97867455
131TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97502632
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96471453
133* HOXB7_26014856_ChIP-Seq_BT474_Human0.96446606
134SPI1_23127762_ChIP-Seq_K562_Human0.96065031
135PU_27001747_Chip-Seq_BMDM_Mouse0.95695408
136STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95542467
137RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95174297
138P300_27268052_Chip-Seq_Bcells_Human0.94189477
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93735096
140BCAT_22108803_ChIP-Seq_LS180_Human0.93707488
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93659141
142ERA_21632823_ChIP-Seq_H3396_Human0.92916317
143GATA2_19941826_ChIP-Seq_K562_Human0.92738513
144OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92585883
145AR_20517297_ChIP-Seq_VCAP_Human0.92261476
146CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91964513
147PU1_27457419_Chip-Seq_LIVER_Mouse0.91000227
148P53_21459846_ChIP-Seq_SAOS-2_Human0.90104640
149OCT4_18555785_Chip-Seq_ESCs_Mouse0.89936470
150SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89688650
151SMAD_19615063_ChIP-ChIP_OVARY_Human0.89679945
152BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89188837
153CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89094550
154P300_18555785_Chip-Seq_ESCs_Mouse0.88852166
155EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88610261
156RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87886557
157GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87165907
158EP300_21415370_ChIP-Seq_HL-1_Mouse0.86489717
159SOX2_18555785_Chip-Seq_ESCs_Mouse0.86454049
160ZFX_18555785_Chip-Seq_ESCs_Mouse0.86178393
161RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85805195
162SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85715807
163EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84215872
164NMYC_18555785_Chip-Seq_ESCs_Mouse0.84110314
165TAL1_26923725_Chip-Seq_HPCs_Mouse0.84051733
166GATA3_26560356_Chip-Seq_TH2_Human0.83613591
167ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83258146
168EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83089421
169ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81777180
170PIAS1_25552417_ChIP-Seq_VCAP_Human0.81643544
171CTCF_18555785_Chip-Seq_ESCs_Mouse0.80510012
172IRF1_19129219_ChIP-ChIP_H3396_Human0.80339067

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.20666749
2MP0005085_abnormal_gallbladder_physiolo4.36571398
3MP0005365_abnormal_bile_salt4.32271868
4MP0005360_urolithiasis4.17609050
5MP0008875_abnormal_xenobiotic_pharmacok3.03114642
6MP0003252_abnormal_bile_duct2.80692191
7MP0002163_abnormal_gland_morphology2.55737498
8MP0003195_calcinosis2.44067296
9MP0005670_abnormal_white_adipose2.40526038
10MP0005379_endocrine/exocrine_gland_phen2.40058359
11MP0003787_abnormal_imprinting2.39866643
12MP0002138_abnormal_hepatobiliary_system2.30133768
13MP0009697_abnormal_copulation2.29542964
14MP0010329_abnormal_lipoprotein_level2.27073663
15MP0004043_abnormal_pH_regulation2.22512188
16MP0001835_abnormal_antigen_presentation2.10240712
17MP0008877_abnormal_DNA_methylation2.08611229
18MP0003724_increased_susceptibility_to1.99130358
19MP0005332_abnormal_amino_acid1.95045965
20MP0000372_irregular_coat_pigmentation1.94280376
21MP0002837_dystrophic_cardiac_calcinosis1.93106511
22MP0003191_abnormal_cellular_cholesterol1.92206299
23MP0008057_abnormal_DNA_replication1.86679670
24MP0001666_abnormal_nutrient_absorption1.84560386
25MP0002009_preneoplasia1.77075030
26MP0000538_abnormal_urinary_bladder1.75511671
27MP0003183_abnormal_peptide_metabolism1.73870889
28MP0005083_abnormal_biliary_tract1.73775953
29MP0005310_abnormal_salivary_gland1.71215884
30MP0000689_abnormal_spleen_morphology1.70990230
31MP0002396_abnormal_hematopoietic_system1.61251218
32MP0002398_abnormal_bone_marrow1.58117802
33MP0003786_premature_aging1.57692432
34MP0000609_abnormal_liver_physiology1.57193387
35MP0005319_abnormal_enzyme/_coenzyme1.57084049
36MP0005584_abnormal_enzyme/coenzyme_acti1.56928086
37MP0002118_abnormal_lipid_homeostasis1.54640694
38MP0004381_abnormal_hair_follicle1.54261507
39MP0009333_abnormal_splenocyte_physiolog1.54035597
40MP0000703_abnormal_thymus_morphology1.51662430
41MP0003868_abnormal_feces_composition1.50541256
42MP0009785_altered_susceptibility_to1.49687102
43MP0002928_abnormal_bile_duct1.49568099
44MP0004084_abnormal_cardiac_muscle1.48729590
45MP0004145_abnormal_muscle_electrophysio1.47770583
46MP0004215_abnormal_myocardial_fiber1.47543684
47MP0009764_decreased_sensitivity_to1.43154528
48MP0002722_abnormal_immune_system1.43070001
49MP0005464_abnormal_platelet_physiology1.39679095
50MP0005084_abnormal_gallbladder_morpholo1.38909310
51MP0002148_abnormal_hypersensitivity_rea1.37870035
52MP0005451_abnormal_body_composition1.37218570
53MP0003806_abnormal_nucleotide_metabolis1.36707585
54MP0003866_abnormal_defecation1.35696594
55MP0006036_abnormal_mitochondrial_physio1.35416292
56MP0000015_abnormal_ear_pigmentation1.35078180
57MP0001764_abnormal_homeostasis1.33014699
58MP0003186_abnormal_redox_activity1.32429371
59MP0002419_abnormal_innate_immunity1.32030106
60MP0004147_increased_porphyrin_level1.31691965
61MP0001986_abnormal_taste_sensitivity1.31107166
62MP0008469_abnormal_protein_level1.29259685
63MP0010368_abnormal_lymphatic_system1.28983209
64MP0005025_abnormal_response_to1.28973854
65MP0009643_abnormal_urine_homeostasis1.28604319
66MP0002254_reproductive_system_inflammat1.27453981
67MP0008961_abnormal_basal_metabolism1.26491895
68MP0005387_immune_system_phenotype1.26232764
69MP0001790_abnormal_immune_system1.26232764
70MP0004036_abnormal_muscle_relaxation1.24568421
71MP0000685_abnormal_immune_system1.24168517
72MP0004019_abnormal_vitamin_homeostasis1.23630577
73MP0003011_delayed_dark_adaptation1.22872400
74MP0002693_abnormal_pancreas_physiology1.22586562
75MP0004233_abnormal_muscle_weight1.22586549
76MP0008058_abnormal_DNA_repair1.22279540
77MP0002876_abnormal_thyroid_physiology1.22030324
78MP0001853_heart_inflammation1.22020469
79MP0001800_abnormal_humoral_immune1.19965355
80MP0003300_gastrointestinal_ulcer1.19175947
81MP0002429_abnormal_blood_cell1.17940637
82MP0004130_abnormal_muscle_cell1.15478499
83MP0000427_abnormal_hair_cycle1.13792018
84MP0009763_increased_sensitivity_to1.12409437
85MP0001873_stomach_inflammation1.09496432
86MP0003646_muscle_fatigue1.08974300
87MP0009840_abnormal_foam_cell1.08308386
88MP0003045_fibrosis1.08225195
89MP0003693_abnormal_embryo_hatching1.07785446
90MP0005671_abnormal_response_to1.07684333
91MP0002405_respiratory_system_inflammati1.07282654
92MP0002723_abnormal_immune_serum1.06080393
93MP0005330_cardiomyopathy1.05177628
94MP0002971_abnormal_brown_adipose1.03044285
95MP0005000_abnormal_immune_tolerance1.00588093
96MP0002909_abnormal_adrenal_gland0.99310996
97MP0003436_decreased_susceptibility_to0.98835393
98MP0003763_abnormal_thymus_physiology0.98705308
99MP0003656_abnormal_erythrocyte_physiolo0.98430432
100MP0002452_abnormal_antigen_presenting0.98179669
101MP0005266_abnormal_metabolism0.97439754
102MP0002166_altered_tumor_susceptibility0.97254592
103MP0002972_abnormal_cardiac_muscle0.96775506
104MP0005408_hypopigmentation0.95978146
105MP0002277_abnormal_respiratory_mucosa0.95661791
106MP0008775_abnormal_heart_ventricle0.95186519
107MP0010094_abnormal_chromosome_stability0.92763370
108MP0001845_abnormal_inflammatory_respons0.92470231
109MP0003828_pulmonary_edema0.91977301
110MP0010155_abnormal_intestine_physiology0.91823884
111MP0000230_abnormal_systemic_arterial0.91578314
112MP0001765_abnormal_ion_homeostasis0.91450345
113MP0004484_altered_response_of0.91393301
114MP0000569_abnormal_digit_pigmentation0.90931426
115MP0002078_abnormal_glucose_homeostasis0.90387073
116MP0005535_abnormal_body_temperature0.88040482
117MP0005666_abnormal_adipose_tissue0.87774339
118MP0004782_abnormal_surfactant_physiolog0.87180729
119MP0009642_abnormal_blood_homeostasis0.86776244
120MP0008872_abnormal_physiological_respon0.86718334
121MP0001879_abnormal_lymphatic_vessel0.86548611
122MP0005334_abnormal_fat_pad0.86129815
123MP0002420_abnormal_adaptive_immunity0.86058503
124MP0001819_abnormal_immune_cell0.85445094
125MP0002332_abnormal_exercise_endurance0.83549708
126MP0005647_abnormal_sex_gland0.82960431
127MP0002019_abnormal_tumor_incidence0.81501805
128MP0000749_muscle_degeneration0.81253900
129MP0000598_abnormal_liver_morphology0.80011979
130MP0008995_early_reproductive_senescence0.79199893
131MP0003172_abnormal_lysosome_physiology0.78306846
132MP0000013_abnormal_adipose_tissue0.77734521
133MP0005075_abnormal_melanosome_morpholog0.77066673
134MP0005220_abnormal_exocrine_pancreas0.76741779
135MP0001544_abnormal_cardiovascular_syste0.76133683
136MP0005385_cardiovascular_system_phenoty0.76133683
137MP0003111_abnormal_nucleus_morphology0.76073696
138MP0005636_abnormal_mineral_homeostasis0.75018545
139MP0000371_diluted_coat_color0.74227920
140MP0002970_abnormal_white_adipose0.73699213
141MP0001756_abnormal_urination0.72910655
142MP0001919_abnormal_reproductive_system0.70539276
143MP0006035_abnormal_mitochondrial_morpho0.70441221
144MP0000470_abnormal_stomach_morphology0.70290479
145MP0000465_gastrointestinal_hemorrhage0.69495037
146MP0002006_tumorigenesis0.68930189
147MP0004947_skin_inflammation0.68532732
148MP0001944_abnormal_pancreas_morphology0.68510372
149MP0001270_distended_abdomen0.67405560
150MP0000716_abnormal_immune_system0.66767285
151MP0009765_abnormal_xenobiotic_induced0.62993413

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)4.68345313
2Prolonged partial thromboplastin time (HP:0003645)4.32555842
3Joint hemorrhage (HP:0005261)4.26507190
4Hypoglycemic coma (HP:0001325)4.14881993
5Intrahepatic cholestasis (HP:0001406)4.05816614
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.97018882
7Renal cortical cysts (HP:0000803)3.95693817
8Pancreatic cysts (HP:0001737)3.89438847
9Pancreatic fibrosis (HP:0100732)3.87038451
10Abnormality of fatty-acid metabolism (HP:0004359)3.69737862
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.53727240
12Abnormality of T cell physiology (HP:0011840)3.47660226
13Severe muscular hypotonia (HP:0006829)3.38483186
14Hyperammonemia (HP:0001987)3.33797928
15Panhypogammaglobulinemia (HP:0003139)3.33639486
16Vascular calcification (HP:0004934)3.31754837
17Ketosis (HP:0001946)3.29970295
18Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20393098
19Dicarboxylic aciduria (HP:0003215)3.20393098
20Type II lissencephaly (HP:0007260)3.17553380
21Abnormality of the intrinsic pathway (HP:0010989)3.16764131
22Progressive muscle weakness (HP:0003323)3.12792399
23Ketoacidosis (HP:0001993)3.10761342
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.08727263
25Hypothermia (HP:0002045)3.07540806
26Abnormality of midbrain morphology (HP:0002418)3.05741306
27Molar tooth sign on MRI (HP:0002419)3.05741306
28Deep venous thrombosis (HP:0002625)3.05361095
29Abnormality of monocarboxylic acid metabolism (HP:0010996)3.00349840
30Cerebellar dysplasia (HP:0007033)2.97567156
31Xanthomatosis (HP:0000991)2.95362220
32Cardiovascular calcification (HP:0011915)2.94955883
33Abnormality of T cells (HP:0002843)2.94491075
34Hyperglycinuria (HP:0003108)2.86322791
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.84568218
36Hepatic necrosis (HP:0002605)2.83184287
37Hypoglycemic seizures (HP:0002173)2.82660838
38Hypobetalipoproteinemia (HP:0003563)2.82170464
39Hyperlipoproteinemia (HP:0010980)2.75550209
40Myoglobinuria (HP:0002913)2.71363173
41Abnormality of methionine metabolism (HP:0010901)2.69138625
42Eczematoid dermatitis (HP:0000976)2.68293843
43Abnormality of serine family amino acid metabolism (HP:0010894)2.65636223
44Abnormality of glycine metabolism (HP:0010895)2.65636223
45Medial flaring of the eyebrow (HP:0010747)2.64284227
46Conjugated hyperbilirubinemia (HP:0002908)2.63054391
47Hyperbilirubinemia (HP:0002904)2.60616536
48Metabolic acidosis (HP:0001942)2.60603607
49Nephronophthisis (HP:0000090)2.59428380
50Recurrent fungal infections (HP:0002841)2.59313930
51Cerebral edema (HP:0002181)2.58787328
52Stomach cancer (HP:0012126)2.57902933
53Abnormality of the common coagulation pathway (HP:0010990)2.54731964
54Cerebral palsy (HP:0100021)2.49321965
55Severe combined immunodeficiency (HP:0004430)2.49134664
56Hypolipoproteinemia (HP:0010981)2.48243831
57Cystic liver disease (HP:0006706)2.47483956
58Tongue fasciculations (HP:0001308)2.47209001
59Abnormality of glutamine family amino acid metabolism (HP:0010902)2.46765374
60Hypoalphalipoproteinemia (HP:0003233)2.45329639
61Gingival bleeding (HP:0000225)2.43467371
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.42136640
63Fat malabsorption (HP:0002630)2.41846305
64Glycosuria (HP:0003076)2.41505052
65Abnormality of urine glucose concentration (HP:0011016)2.41505052
66Subaortic stenosis (HP:0001682)2.40924082
67Abnormality of the left ventricular outflow tract (HP:0011103)2.40924082
68Abnormality of the renal medulla (HP:0100957)2.36860854
69Tinnitus (HP:0000360)2.36117979
70Muscle fibrillation (HP:0010546)2.34396657
71Epidermoid cyst (HP:0200040)2.34104273
72Abnormality of sulfur amino acid metabolism (HP:0004339)2.33661568
73Recurrent gram-negative bacterial infections (HP:0005420)2.32726881
74IgG deficiency (HP:0004315)2.31872888
75Recurrent abscess formation (HP:0002722)2.31643929
76Complement deficiency (HP:0004431)2.31321125
77Palpitations (HP:0001962)2.31237128
78Ventricular tachycardia (HP:0004756)2.30868188
79Proximal tubulopathy (HP:0000114)2.30801473
80Lipoatrophy (HP:0100578)2.28838195
81Aplasia/Hypoplasia of the spleen (HP:0010451)2.28525687
82Pachygyria (HP:0001302)2.28232459
83Asplenia (HP:0001746)2.26786053
84Pustule (HP:0200039)2.24437480
85Cheilitis (HP:0100825)2.22244328
86J-shaped sella turcica (HP:0002680)2.22233149
87Lethargy (HP:0001254)2.20817404
88Abnormality of purine metabolism (HP:0004352)2.20580493
89Atrial fibrillation (HP:0005110)2.19436501
90Elevated hepatic transaminases (HP:0002910)2.18707970
91Congenital stationary night blindness (HP:0007642)2.18581379
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17043617
93Hypoplasia of the pons (HP:0012110)2.16700581
94Rhabdomyolysis (HP:0003201)2.15710310
95Recurrent cutaneous fungal infections (HP:0011370)2.15231142
96Chronic mucocutaneous candidiasis (HP:0002728)2.15231142
97IgM deficiency (HP:0002850)2.14927547
98Abnormality of serum amino acid levels (HP:0003112)2.14274165
99Abnormality of nucleobase metabolism (HP:0010932)2.13925185
100Recurrent bacterial skin infections (HP:0005406)2.13465394
101Pancreatitis (HP:0001733)2.12908140
102Prolonged bleeding time (HP:0003010)2.12339400
103Abnormality of the renal cortex (HP:0011035)2.11433234
104Symptomatic seizures (HP:0011145)2.11030043
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10959161
106Abnormality of alanine metabolism (HP:0010916)2.10959161
107Hyperalaninemia (HP:0003348)2.10959161
108Abnormality of T cell number (HP:0011839)2.08593776
109Increased muscle lipid content (HP:0009058)2.08560062
110Neoplasm of the adrenal cortex (HP:0100641)2.08410223
111Hyperinsulinemic hypoglycemia (HP:0000825)2.07325996
112Menorrhagia (HP:0000132)2.05774135
113Chronic otitis media (HP:0000389)2.05539759
114Growth hormone excess (HP:0000845)2.04610006
115T lymphocytopenia (HP:0005403)2.03926922
116Autoimmune hemolytic anemia (HP:0001890)2.03747078
117Disproportionate short-trunk short stature (HP:0003521)2.03410121
118Nausea (HP:0002018)2.03304260
119Hyperglycinemia (HP:0002154)2.02492939
120Abnormality of the pons (HP:0007361)2.02203895
121Hepatocellular necrosis (HP:0001404)2.01383334
122Chronic diarrhea (HP:0002028)2.00746219
123Abnormality of pyrimidine metabolism (HP:0004353)2.00614571
124Right ventricular cardiomyopathy (HP:0011663)1.97514629
125Increased serum lactate (HP:0002151)1.96580911
126Lissencephaly (HP:0001339)1.96468432
127Hypoplasia of the thymus (HP:0000778)1.95110725
128Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94907050
129Hypercholesterolemia (HP:0003124)1.94339594
130Tubular atrophy (HP:0000092)1.93897696
131Lactic acidosis (HP:0003128)1.91956353
132Abnormality of DNA repair (HP:0003254)1.90862424
133Epistaxis (HP:0000421)1.90480075
134Acute encephalopathy (HP:0006846)1.90245686
135Bone cyst (HP:0012062)1.88971243
136High pitched voice (HP:0001620)1.88430992
137Primary atrial arrhythmia (HP:0001692)1.87623872
138Dilated cardiomyopathy (HP:0001644)1.87533185
139Hepatocellular carcinoma (HP:0001402)1.86502158
140Exercise-induced myalgia (HP:0003738)1.86332826
141Pancreatic islet-cell hyperplasia (HP:0004510)1.86256018
142Large for gestational age (HP:0001520)1.84693957
143Asymmetric septal hypertrophy (HP:0001670)1.84612884
144Myocardial infarction (HP:0001658)1.83937774
145Vomiting (HP:0002013)1.83908464
146Furrowed tongue (HP:0000221)1.83589408
147Sudden death (HP:0001699)1.83477843
148True hermaphroditism (HP:0010459)1.83402654
149Stomatitis (HP:0010280)1.83261727
150Increased neuronal autofluorescent lipopigment (HP:0002074)1.82680704
151Hyperventilation (HP:0002883)1.81508383
152Steatorrhea (HP:0002570)1.81501541
153Supraventricular tachycardia (HP:0004755)1.80435145
154Attenuation of retinal blood vessels (HP:0007843)1.80378792
155Agammaglobulinemia (HP:0004432)1.78549464
156Recurrent viral infections (HP:0004429)1.78155408
157Poor coordination (HP:0002370)1.77578484
158Clumsiness (HP:0002312)1.76746106
159Elevated erythrocyte sedimentation rate (HP:0003565)1.75486876
160Increased intramyocellular lipid droplets (HP:0012240)1.75044776
161Microretrognathia (HP:0000308)1.74905354
162Dysautonomia (HP:0002459)1.74785002
163Reduced antithrombin III activity (HP:0001976)1.74191245
164Intellectual disability, progressive (HP:0006887)1.74015756
165Inflammation of the large intestine (HP:0002037)1.73141197
166Decreased circulating renin level (HP:0003351)1.72108393
167Axonal loss (HP:0003447)1.71702966
168Colitis (HP:0002583)1.71686695
169Supraventricular arrhythmia (HP:0005115)1.71532032
170Albinism (HP:0001022)1.67551533
171Congenital primary aphakia (HP:0007707)1.66971157
172Nephrogenic diabetes insipidus (HP:0009806)1.64998723
173Abnormality of chromosome stability (HP:0003220)1.63233830
174Protruding tongue (HP:0010808)1.63233201
175Neuroendocrine neoplasm (HP:0100634)1.62677188
176Hyperkalemia (HP:0002153)1.62223271
177Decreased electroretinogram (ERG) amplitude (HP:0000654)1.62071237
178Absent rod-and cone-mediated responses on ERG (HP:0007688)1.60997845
179Encephalitis (HP:0002383)1.60760194
180Abnormal drinking behavior (HP:0030082)1.59588696
181Polydipsia (HP:0001959)1.59588696
182Abnormal rod and cone electroretinograms (HP:0008323)1.58414267
183Progressive inability to walk (HP:0002505)1.57468532
184Heterotopia (HP:0002282)1.56540154
185Chromsome breakage (HP:0040012)1.56354714
186Increased CSF lactate (HP:0002490)1.56037906
187Papilloma (HP:0012740)1.54625294
188Verrucae (HP:0200043)1.54625294
189Anorexia (HP:0002039)1.53668366
190Congenital hepatic fibrosis (HP:0002612)1.52769425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B3.38410103
2BCKDK3.36919338
3INSRR3.08007469
4FRK2.50935320
5FLT32.45128045
6WNK42.40252952
7TXK2.27833871
8TGFBR22.22945560
9MYLK2.20341172
10MAP3K142.14343482
11TEC2.11398239
12LATS12.03495245
13IRAK12.03456522
14LMTK21.99952785
15IRAK31.96930517
16MAP4K11.89762772
17TAOK31.87084484
18KIT1.86722397
19ZAK1.84717997
20TNK21.84541011
21MAPKAPK31.78060657
22TYK21.74848285
23NEK91.72196770
24GRK61.69283043
25MAP3K71.67927872
26MAPK71.64007915
27MUSK1.63783323
28JAK11.60728921
29IRAK21.58306479
30PIK3CG1.56986317
31GRK71.56784833
32SIK11.46894236
33TIE11.43864758
34PHKG11.42857526
35PHKG21.42857526
36BTK1.41597544
37ACVR1B1.33323678
38OBSCN1.32684305
39CSF1R1.32288498
40IRAK41.32146586
41MAP2K61.31913870
42EEF2K1.29993916
43PLK41.29268506
44ERN11.28041160
45FGFR41.25411752
46MAP3K31.23331755
47TBK11.20862499
48TLK11.19390669
49EIF2AK21.19284328
50IKBKB1.18915118
51PIK3CA1.15873463
52TRIB31.12724871
53TRPM71.10625181
54JAK31.10565174
55EPHA31.09820242
56MAP3K131.09106962
57EPHB11.08326196
58MAP2K31.08274195
59PTK61.08106793
60TTN1.05963383
61MST41.03609697
62BLK1.01495959
63TAF11.00849810
64CASK0.99795090
65MARK30.99089408
66RIPK10.98136352
67MAPK110.97752788
68IKBKE0.97511589
69ITK0.96128554
70TGFBR10.95746894
71STK160.95251452
72STK240.94784307
73RIPK40.94668855
74JAK20.94386145
75SGK20.92673902
76GRK10.91935472
77SYK0.90515204
78PRKAA20.87935414
79NME20.87583732
80RPS6KB20.87224963
81STK390.86513874
82PRKG20.85217574
83NME10.84351519
84FES0.84149237
85HIPK20.83328621
86CAMK10.83310810
87MAP4K20.79985686
88CAMK40.77921484
89PKN20.76503375
90SIK20.76435683
91MAPK40.76236197
92ADRBK20.75759120
93RPS6KA60.75220654
94RPS6KL10.73134797
95RPS6KC10.73134797
96CAMK1D0.71847450
97LYN0.71384386
98SGK30.67982773
99MAPK120.67270425
100FGFR30.66787917
101PDK40.65574583
102PDK30.65574583
103PTK2B0.63815251
104NUAK10.63565169
105CDK80.63305704
106MAP3K20.62868895
107ZAP700.62157174
108PRKCQ0.61460041
109NLK0.61075528
110PINK10.60585027
111CCNB10.60470701
112HCK0.59666005
113PDK10.57226622
114MAP2K20.57082850
115MAPK150.57029995
116SMG10.56593740
117MAP2K70.56458015
118PKN10.56308787
119ATR0.56058309
120CHEK20.53114294
121STK30.52704928
122MAP2K10.51293756
123CHUK0.47851776
124WNK10.47724696
125LCK0.47634969
126RPS6KA20.47535288
127TAOK20.46521783
128CSK0.46242836
129NEK60.46191336
130MELK0.46061495
131CAMK2D0.44883631
132CAMKK20.44705603
133BRD40.43786990
134ILK0.43232875
135CDK40.42995569
136SIK30.42757378
137BMX0.42425462
138PRKCH0.42172982
139CDK70.41673296
140PRKCD0.41359122
141CLK10.40966152
142VRK20.40864812
143STK100.40805905
144PIM10.36931917
145YES10.36204760
146PRKD20.35991179
147MAPKAPK20.35430287
148PRKAA10.35147812
149VRK10.30283879
150ADRBK10.29160816

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000713.38543116
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.18519506
3Propanoate metabolism_Homo sapiens_hsa006403.09629896
4Homologous recombination_Homo sapiens_hsa034402.91307976
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.88218032
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.72614782
7Tryptophan metabolism_Homo sapiens_hsa003802.63932957
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52625604
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.45909415
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.44880955
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.44831050
12Caffeine metabolism_Homo sapiens_hsa002322.36643748
13Fatty acid metabolism_Homo sapiens_hsa012122.32210488
14Peroxisome_Homo sapiens_hsa041462.22867329
15T cell receptor signaling pathway_Homo sapiens_hsa046602.20428023
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18827864
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16156510
18Histidine metabolism_Homo sapiens_hsa003402.14626438
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10745498
20One carbon pool by folate_Homo sapiens_hsa006702.08746731
21beta-Alanine metabolism_Homo sapiens_hsa004102.08522513
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05812154
23Fanconi anemia pathway_Homo sapiens_hsa034602.00381349
24Complement and coagulation cascades_Homo sapiens_hsa046101.99011620
25Fatty acid elongation_Homo sapiens_hsa000621.87503187
26PPAR signaling pathway_Homo sapiens_hsa033201.81078569
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80842177
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80820579
29Butanoate metabolism_Homo sapiens_hsa006501.75996421
30Arginine biosynthesis_Homo sapiens_hsa002201.71529699
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.69461497
32Pyrimidine metabolism_Homo sapiens_hsa002401.69158141
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.66404934
34RNA polymerase_Homo sapiens_hsa030201.66057333
35Starch and sucrose metabolism_Homo sapiens_hsa005001.65787952
36Chemical carcinogenesis_Homo sapiens_hsa052041.65468106
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64260474
38ABC transporters_Homo sapiens_hsa020101.60760154
39Pyruvate metabolism_Homo sapiens_hsa006201.56541013
40Retinol metabolism_Homo sapiens_hsa008301.52736975
41RNA degradation_Homo sapiens_hsa030181.52416222
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52290326
43Staphylococcus aureus infection_Homo sapiens_hsa051501.51367474
44Base excision repair_Homo sapiens_hsa034101.44116676
45Vitamin digestion and absorption_Homo sapiens_hsa049771.43106934
46Phenylalanine metabolism_Homo sapiens_hsa003601.37339273
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36711882
48Sulfur metabolism_Homo sapiens_hsa009201.36070621
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.29864645
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26795394
51Nitrogen metabolism_Homo sapiens_hsa009101.26736111
52Carbon metabolism_Homo sapiens_hsa012001.24990384
53Acute myeloid leukemia_Homo sapiens_hsa052211.21256240
54Purine metabolism_Homo sapiens_hsa002301.21064412
55Folate biosynthesis_Homo sapiens_hsa007901.20955278
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19035100
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19029075
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18814682
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16392260
60Tyrosine metabolism_Homo sapiens_hsa003501.16340016
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.15836397
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09829529
63Regulation of autophagy_Homo sapiens_hsa041401.09025768
64Lysine degradation_Homo sapiens_hsa003101.01069242
65Non-homologous end-joining_Homo sapiens_hsa034500.99717279
66Basal transcription factors_Homo sapiens_hsa030220.99244896
67Selenocompound metabolism_Homo sapiens_hsa004500.96639756
68DNA replication_Homo sapiens_hsa030300.95492140
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.90416079
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88119178
71Arginine and proline metabolism_Homo sapiens_hsa003300.88101352
72Bile secretion_Homo sapiens_hsa049760.86417990
73Non-small cell lung cancer_Homo sapiens_hsa052230.85316765
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.83724653
75Mismatch repair_Homo sapiens_hsa034300.82016832
76RNA transport_Homo sapiens_hsa030130.81668078
77Nucleotide excision repair_Homo sapiens_hsa034200.77376483
78Other glycan degradation_Homo sapiens_hsa005110.77214995
79Glycerolipid metabolism_Homo sapiens_hsa005610.76914840
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76865115
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73020277
82Asthma_Homo sapiens_hsa053100.71821761
83mTOR signaling pathway_Homo sapiens_hsa041500.67112139
84Viral carcinogenesis_Homo sapiens_hsa052030.66106128
85Ovarian steroidogenesis_Homo sapiens_hsa049130.64627101
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64048231
87Insulin resistance_Homo sapiens_hsa049310.63790896
88Fat digestion and absorption_Homo sapiens_hsa049750.62494229
89Hepatitis B_Homo sapiens_hsa051610.62177795
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61467408
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.60754847
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60639678
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60511328
94Biosynthesis of amino acids_Homo sapiens_hsa012300.59381097
95Hematopoietic cell lineage_Homo sapiens_hsa046400.59069837
96Autoimmune thyroid disease_Homo sapiens_hsa053200.58741926
97Ether lipid metabolism_Homo sapiens_hsa005650.57760469
98Parkinsons disease_Homo sapiens_hsa050120.57700754
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57635329
100Phototransduction_Homo sapiens_hsa047440.57293675
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57151924
102VEGF signaling pathway_Homo sapiens_hsa043700.56830614
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56719255
104Type I diabetes mellitus_Homo sapiens_hsa049400.56606753
105Primary immunodeficiency_Homo sapiens_hsa053400.56498712
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.56465153
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.55267225
108Allograft rejection_Homo sapiens_hsa053300.54752676
109Sulfur relay system_Homo sapiens_hsa041220.54062646
110Glutathione metabolism_Homo sapiens_hsa004800.53692600
111Metabolic pathways_Homo sapiens_hsa011000.53291663
112Leishmaniasis_Homo sapiens_hsa051400.51033251
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50683034
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50274213
115FoxO signaling pathway_Homo sapiens_hsa040680.48484043
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44614733
117Epstein-Barr virus infection_Homo sapiens_hsa051690.44513068
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43086590
119Platelet activation_Homo sapiens_hsa046110.42958447
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42194152
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41076529
122Pentose phosphate pathway_Homo sapiens_hsa000300.40675358
123Prostate cancer_Homo sapiens_hsa052150.40661700
124Apoptosis_Homo sapiens_hsa042100.40621795
125p53 signaling pathway_Homo sapiens_hsa041150.40358555
126Osteoclast differentiation_Homo sapiens_hsa043800.40065914
127Olfactory transduction_Homo sapiens_hsa047400.39908547
128Inositol phosphate metabolism_Homo sapiens_hsa005620.39383733
129Measles_Homo sapiens_hsa051620.39295366
130Galactose metabolism_Homo sapiens_hsa000520.38177836
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37697466
132Huntingtons disease_Homo sapiens_hsa050160.36985465
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36270828
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35612069
135Arachidonic acid metabolism_Homo sapiens_hsa005900.34163214
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33863468
137Oxidative phosphorylation_Homo sapiens_hsa001900.32224884
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.31779103
139Linoleic acid metabolism_Homo sapiens_hsa005910.30972672
140B cell receptor signaling pathway_Homo sapiens_hsa046620.29991458
141Glucagon signaling pathway_Homo sapiens_hsa049220.29787532
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.29237149
143Protein export_Homo sapiens_hsa030600.26567629
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22991985
145Malaria_Homo sapiens_hsa051440.22677995
146Graft-versus-host disease_Homo sapiens_hsa053320.21682812
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21256146
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20177747
149SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19191325
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18228662
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16785985
152TNF signaling pathway_Homo sapiens_hsa046680.16783164
153Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15515871
154Dilated cardiomyopathy_Homo sapiens_hsa054140.15273840
155Herpes simplex infection_Homo sapiens_hsa051680.14934023

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