TRMT44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a putative tRNA methyltransferase found in the cytoplasm. Defects in this gene may be a cause of partial epilepsy with pericentral spikes (PEPS), but that has not been proven definitively. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cell fate commitment (GO:0072148)7.29363567
2lung epithelium development (GO:0060428)6.82895949
3protein K11-linked deubiquitination (GO:0035871)6.81749655
4chondrocyte proliferation (GO:0035988)5.68877712
5epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.52472636
6lens fiber cell development (GO:0070307)5.40392859
7regulation of acrosome reaction (GO:0060046)5.27394469
8response to muramyl dipeptide (GO:0032495)4.87795928
9negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.87681827
10daunorubicin metabolic process (GO:0044597)4.83553992
11polyketide metabolic process (GO:0030638)4.83553992
12doxorubicin metabolic process (GO:0044598)4.83553992
13positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.80920530
14ventricular trabecula myocardium morphogenesis (GO:0003222)4.75505908
15cell migration involved in heart development (GO:0060973)4.69544676
16mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.69506499
17neuron projection extension involved in neuron projection guidance (GO:1902284)4.63772496
18axon extension involved in axon guidance (GO:0048846)4.63772496
19somite rostral/caudal axis specification (GO:0032525)4.56589435
20embryonic camera-type eye development (GO:0031076)4.53584234
21regulation of female gonad development (GO:2000194)4.51765962
22venous blood vessel morphogenesis (GO:0048845)4.51760471
23Notch signaling involved in heart development (GO:0061314)4.46844552
24heart valve formation (GO:0003188)4.33163839
25histone mRNA catabolic process (GO:0071044)4.31365033
26multicellular organism reproduction (GO:0032504)4.24789508
27myoblast migration (GO:0051451)4.23582177
28regulation of meiosis I (GO:0060631)4.22728820
29regulation of mesoderm development (GO:2000380)4.21632524
30detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.18011166
31base-excision repair, AP site formation (GO:0006285)4.17108462
32regulation of somitogenesis (GO:0014807)4.14431688
33endocardial cushion morphogenesis (GO:0003203)4.09418743
34somite development (GO:0061053)4.09160563
35negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.06760005
36negative regulation of T-helper cell differentiation (GO:0045623)4.06760005
37piRNA metabolic process (GO:0034587)3.98108596
38axon ensheathment in central nervous system (GO:0032291)3.95486836
39central nervous system myelination (GO:0022010)3.95486836
40negative regulation of activin receptor signaling pathway (GO:0032926)3.93819969
41heart trabecula morphogenesis (GO:0061384)3.87205489
42positive regulation of keratinocyte differentiation (GO:0045618)3.86602919
43positive regulation of histone H3-K4 methylation (GO:0051571)3.85697989
44interferon-gamma production (GO:0032609)3.81808109
45negative regulation of myotube differentiation (GO:0010832)3.80851784
46neural tube formation (GO:0001841)3.78653075
47DNA replication-dependent nucleosome organization (GO:0034723)3.75273498
48DNA replication-dependent nucleosome assembly (GO:0006335)3.75273498
49hepatocyte apoptotic process (GO:0097284)3.74512649
50negative regulation of epidermis development (GO:0045683)3.73320229
51negative regulation of astrocyte differentiation (GO:0048712)3.73087010
52regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.70375292
53neuronal stem cell maintenance (GO:0097150)3.69719680
54negative regulation of oligodendrocyte differentiation (GO:0048715)3.69237993
55barbed-end actin filament capping (GO:0051016)3.67398606
56oocyte development (GO:0048599)3.67318104
57negative regulation of cAMP-mediated signaling (GO:0043951)3.67051335
58centriole replication (GO:0007099)3.60308420
59female gamete generation (GO:0007292)3.57187242
60regulation of telomere maintenance via telomerase (GO:0032210)3.57167998
61DNA strand elongation involved in DNA replication (GO:0006271)3.53251790
62regulation of extracellular matrix organization (GO:1903053)3.52068918
63positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.51410552
64positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.51410552
65positive regulation of mitotic sister chromatid separation (GO:1901970)3.51410552
66apoptotic process involved in morphogenesis (GO:0060561)3.50252538
67attachment of spindle microtubules to kinetochore (GO:0008608)3.49755251
68negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.49667287
69DNA methylation involved in gamete generation (GO:0043046)3.48771400
70DNA strand elongation (GO:0022616)3.47711960
71protein prenylation (GO:0018342)3.47367365
72prenylation (GO:0097354)3.47367365
73inner ear receptor cell differentiation (GO:0060113)3.46314069
74exocrine pancreas development (GO:0031017)3.43803416
75DNA deamination (GO:0045006)3.43000669
76retinal cone cell development (GO:0046549)3.41768016
77atrioventricular valve morphogenesis (GO:0003181)3.40940411
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.40008660
79epithelial cell differentiation involved in prostate gland development (GO:0060742)3.39467522
80cell migration involved in gastrulation (GO:0042074)3.36836566
81detection of chemical stimulus involved in sensory perception (GO:0050907)3.36506207
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.34331523
83paraxial mesoderm development (GO:0048339)3.33070863
84mesenchyme morphogenesis (GO:0072132)3.31362106
85regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.31058059
86trabecula morphogenesis (GO:0061383)3.30222807
87telomere maintenance via semi-conservative replication (GO:0032201)3.29062089
88regulation of stem cell maintenance (GO:2000036)3.28766278
89histone H3-K4 trimethylation (GO:0080182)3.28197618
90negative regulation of glial cell proliferation (GO:0060253)3.26565766
91viral mRNA export from host cell nucleus (GO:0046784)3.24960343
92negative regulation of glial cell differentiation (GO:0045686)3.23527066
93regulation of endothelial cell chemotaxis (GO:2001026)3.23099134
94thalamus development (GO:0021794)3.22758481
95regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.22059788
96phospholipid scrambling (GO:0017121)3.21449920
97collecting duct development (GO:0072044)3.18865122
98regulation of T-helper 1 cell differentiation (GO:0045625)3.18483348
99chaperone mediated protein folding requiring cofactor (GO:0051085)3.16799470
100endoderm formation (GO:0001706)3.12498987
101midgut development (GO:0007494)3.12471108
102dopamine transport (GO:0015872)3.10868333
103regulation of nuclear cell cycle DNA replication (GO:0033262)3.10130051
104coronary vasculature morphogenesis (GO:0060977)3.08980780
105negative regulation of myoblast differentiation (GO:0045662)3.08261983
106male meiosis (GO:0007140)3.07821931
107establishment of protein localization to Golgi (GO:0072600)3.07204653
108dorsal/ventral neural tube patterning (GO:0021904)3.04543743
109gene silencing by RNA (GO:0031047)3.04540957
110negative regulation of mitosis (GO:0045839)3.03758556
111regulation of DNA methylation (GO:0044030)3.03715408
112DNA replication checkpoint (GO:0000076)3.03044594
113negative regulation of B cell proliferation (GO:0030889)3.02422538
114negative regulation of alpha-beta T cell differentiation (GO:0046639)3.01617674
115regulation of astrocyte differentiation (GO:0048710)3.01027262
116kinetochore assembly (GO:0051382)2.99040126
117positive regulation of astrocyte differentiation (GO:0048711)2.97887254
118cardiac left ventricle morphogenesis (GO:0003214)2.97367840
119detection of biotic stimulus (GO:0009595)2.97126133
120pyrimidine nucleotide catabolic process (GO:0006244)2.96984049
121seminiferous tubule development (GO:0072520)2.96894737
122regulation of activation of Janus kinase activity (GO:0010533)2.95675763
123tryptophan catabolic process (GO:0006569)2.95479801
124indole-containing compound catabolic process (GO:0042436)2.95479801
125indolalkylamine catabolic process (GO:0046218)2.95479801
126tryptophan metabolic process (GO:0006568)2.95424246
127telomere maintenance via telomere lengthening (GO:0010833)2.95086047
128renal system development (GO:0072001)2.94459357
129replicative senescence (GO:0090399)2.94404920
130nodal signaling pathway (GO:0038092)2.94324753
131forebrain morphogenesis (GO:0048853)2.93268580
132signal transduction involved in regulation of gene expression (GO:0023019)2.93204461
133kinetochore organization (GO:0051383)2.92450312
134centriole assembly (GO:0098534)2.90093422
135pericardium development (GO:0060039)2.89651023
136mismatch repair (GO:0006298)2.86642656
137peptidyl-lysine trimethylation (GO:0018023)2.86060957
138telomere maintenance via recombination (GO:0000722)2.85934064
139male meiosis I (GO:0007141)2.85070620
140replication fork processing (GO:0031297)2.84685847
141regulation of helicase activity (GO:0051095)2.84448845
142type B pancreatic cell development (GO:0003323)2.84303243
143spindle assembly checkpoint (GO:0071173)2.83853940
144N-terminal protein amino acid acetylation (GO:0006474)2.83851277
145telomere maintenance via telomerase (GO:0007004)2.82463948
146regulation of histone H3-K9 methylation (GO:0051570)2.81879706
147protein targeting to Golgi (GO:0000042)2.81158349
148embryonic axis specification (GO:0000578)2.80374404
149left/right axis specification (GO:0070986)2.79132001
150cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.78960898
151digestive tract morphogenesis (GO:0048546)2.78158115
152regulation of B cell receptor signaling pathway (GO:0050855)2.76912877
153mitotic spindle assembly checkpoint (GO:0007094)2.76716728
154oogenesis (GO:0048477)2.75759463
155positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.75490331
156response to pheromone (GO:0019236)2.75331502
157aminoglycoside antibiotic metabolic process (GO:0030647)2.75141968
158negative regulation of smoothened signaling pathway (GO:0045879)2.74506573
159base-excision repair (GO:0006284)2.73310097
160female gonad development (GO:0008585)2.72589936
161negative regulation of chromosome segregation (GO:0051985)2.71734370
162negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71237286
163negative regulation of sister chromatid segregation (GO:0033046)2.71237286
164negative regulation of mitotic sister chromatid separation (GO:2000816)2.71237286
165negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71237286
166apoptotic process involved in development (GO:1902742)2.70639081
167regulation of activin receptor signaling pathway (GO:0032925)2.70263873
168developmental programmed cell death (GO:0010623)2.68953317
169synapsis (GO:0007129)2.68650237
170meiotic cell cycle (GO:0051321)2.67413353
171phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.67104908
172detection of chemical stimulus (GO:0009593)2.65096136
173anterior/posterior axis specification (GO:0009948)2.63507499
174positive regulation of humoral immune response (GO:0002922)2.62898838
175RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62746347
176indolalkylamine metabolic process (GO:0006586)2.59590338
177negative regulation of alpha-beta T cell activation (GO:0046636)2.59494188
178positive regulation of histone methylation (GO:0031062)2.59118727
179positive regulation of RNA splicing (GO:0033120)2.58911799
180negative regulation of execution phase of apoptosis (GO:1900118)2.57209459
181histone H3-K4 methylation (GO:0051568)2.56064481
182double-strand break repair via homologous recombination (GO:0000724)2.54337440
183gastrulation (GO:0007369)2.53945772
184fucose catabolic process (GO:0019317)2.53908405
185L-fucose metabolic process (GO:0042354)2.53908405
186L-fucose catabolic process (GO:0042355)2.53908405
187mitotic G2/M transition checkpoint (GO:0044818)2.52925313
188retrograde transport, vesicle recycling within Golgi (GO:0000301)2.52559296
189righting reflex (GO:0060013)2.51596906
190activin receptor signaling pathway (GO:0032924)2.49802149
191negative regulation of mast cell activation (GO:0033004)2.49741891
192signal peptide processing (GO:0006465)2.48942018
193Rap protein signal transduction (GO:0032486)2.48871052
194regulation of DNA damage checkpoint (GO:2000001)2.48310309
195recombinational repair (GO:0000725)2.47850963
196positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.45910462
197cAMP biosynthetic process (GO:0006171)2.45766012
198T cell differentiation involved in immune response (GO:0002292)2.45298309
199alpha-beta T cell activation involved in immune response (GO:0002287)2.45298309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.11279041
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.16579447
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.82244485
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.63334662
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.51617230
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.20794993
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90250547
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.87927910
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.76477708
10GBX2_23144817_ChIP-Seq_PC3_Human2.62960815
11IGF1R_20145208_ChIP-Seq_DFB_Human2.58552792
12VDR_22108803_ChIP-Seq_LS180_Human2.52933074
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51771025
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.42850538
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39723434
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39181635
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34718944
18ZNF274_21170338_ChIP-Seq_K562_Hela2.31529793
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30844571
20EZH2_22144423_ChIP-Seq_EOC_Human2.28466720
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.28230656
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.25621939
23AR_21909140_ChIP-Seq_LNCAP_Human2.18618516
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11437319
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09658380
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.06353644
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03871891
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02984270
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.01395839
30P300_19829295_ChIP-Seq_ESCs_Human2.01144335
31E2F7_22180533_ChIP-Seq_HELA_Human10.3294291
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98689645
33XRN2_22483619_ChIP-Seq_HELA_Human1.98109850
34SMAD3_21741376_ChIP-Seq_HESCs_Human1.96006579
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.95542988
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95383488
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.95370200
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.94814627
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89103384
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.88051885
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87708259
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87619561
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87138346
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.81852862
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81852862
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.80479675
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80362690
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79926676
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.79559706
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78093910
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.76979542
52EWS_26573619_Chip-Seq_HEK293_Human1.75810498
53FUS_26573619_Chip-Seq_HEK293_Human1.75713159
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.74907467
55MYC_22102868_ChIP-Seq_BL_Human1.74726205
56BCAT_22108803_ChIP-Seq_LS180_Human1.74533852
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74508948
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74212659
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71959206
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71868164
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71361730
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70549792
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70109282
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68587084
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68530764
66VDR_21846776_ChIP-Seq_THP-1_Human1.65522097
67SMAD4_21741376_ChIP-Seq_EPCs_Human1.63455234
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62977154
69CIITA_25753668_ChIP-Seq_RAJI_Human1.62411356
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61332666
71VDR_23849224_ChIP-Seq_CD4+_Human1.61256955
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60977024
73CBP_20019798_ChIP-Seq_JUKART_Human1.60701657
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60701657
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.59129445
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58120277
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56395311
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.56345064
79STAT3_23295773_ChIP-Seq_U87_Human1.56334066
80FOXP3_21729870_ChIP-Seq_TREG_Human1.53328307
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52693438
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.52186509
83SMAD4_21799915_ChIP-Seq_A2780_Human1.51764658
84ER_23166858_ChIP-Seq_MCF-7_Human1.51554165
85SCL_19346495_ChIP-Seq_HPC-7_Human1.50744165
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50704308
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.50100492
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48733253
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45543363
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.45115001
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43757699
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41074452
93THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40832203
94IRF8_22096565_ChIP-ChIP_GC-B_Human1.39594386
95AR_21572438_ChIP-Seq_LNCaP_Human1.38745633
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37774801
97TP53_16413492_ChIP-PET_HCT116_Human1.37113541
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36364786
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35396988
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33058021
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33005065
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32951303
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30949564
104TCF4_22108803_ChIP-Seq_LS180_Human1.30783918
105CDX2_22108803_ChIP-Seq_LS180_Human1.30183942
106SMAD4_21741376_ChIP-Seq_HESCs_Human1.29823313
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29559065
108MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29417096
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28806823
110TCF4_23295773_ChIP-Seq_U87_Human1.28636437
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27203929
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26765309
113AR_25329375_ChIP-Seq_VCAP_Human1.26670158
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26017536
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.25286011
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25165295
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.25063905
118HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24685524
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24635472
120FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24582421
121SPI1_23547873_ChIP-Seq_NB4_Human1.23759157
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23439755
123FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22392384
124GATA1_26923725_Chip-Seq_HPCs_Mouse1.22220134
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21956987
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21607938
127NANOG_18555785_Chip-Seq_ESCs_Mouse1.21601315
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.20078756
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19066518
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15714609
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15665363
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15024723
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13739194
134DCP1A_22483619_ChIP-Seq_HELA_Human1.13350003
135NANOG_19829295_ChIP-Seq_ESCs_Human1.12815533
136SOX2_19829295_ChIP-Seq_ESCs_Human1.12815533
137OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12546195
138* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11956217
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11576394
140FLI1_21867929_ChIP-Seq_TH2_Mouse1.11484492
141NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11415281
142FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11117707
143TAF15_26573619_Chip-Seq_HEK293_Human1.11045061
144E2F1_18555785_Chip-Seq_ESCs_Mouse1.10289341
145SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10091651
146SOX2_16153702_ChIP-ChIP_HESCs_Human1.09374381
147KDM2B_26808549_Chip-Seq_REH_Human1.08642240
148TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08394748
149GABP_19822575_ChIP-Seq_HepG2_Human1.08209328
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07373565
151CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07301945
152RUNX2_22187159_ChIP-Seq_PCA_Human1.06248953
153TTF2_22483619_ChIP-Seq_HELA_Human1.06220096
154SMRT_27268052_Chip-Seq_Bcells_Human1.05405311
155BP1_19119308_ChIP-ChIP_Hs578T_Human1.05337848
156ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03952154
157GATA3_26560356_Chip-Seq_TH1_Human1.03028832
158MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02941942
159VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01652318
160TBL1_22424771_ChIP-Seq_293T_Human0.99623094
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99605226
162SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99527397
163TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99332406
164VDR_24787735_ChIP-Seq_THP-1_Human0.99108279
165KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98331960
166ARNT_22903824_ChIP-Seq_MCF-7_Human0.97333041
167ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96919495
168SRF_21415370_ChIP-Seq_HL-1_Mouse0.96915678
169MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96669738
170KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95204489
171GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91807420
172NANOG_16153702_ChIP-ChIP_HESCs_Human0.91554974
173E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88381475
174PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85148291
175TFEB_21752829_ChIP-Seq_HELA_Human0.84014677
176TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83524542
177KDM5A_27292631_Chip-Seq_BREAST_Human0.83318263
178STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82963601
179SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82651341
180ELK1_19687146_ChIP-ChIP_HELA_Human0.82191505
181EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81300849
182POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78344723
183NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.76105573
184RUNX1_22412390_ChIP-Seq_EML_Mouse0.75567227
185SOX2_18692474_ChIP-Seq_MESCs_Mouse0.73163971
186SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73008970
187CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72761127
188KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71401427
189IRF1_19129219_ChIP-ChIP_H3396_Human0.70266617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis9.62163773
2MP0010030_abnormal_orbit_morphology5.00355386
3MP0003890_abnormal_embryonic-extraembry4.90678506
4MP0009780_abnormal_chondrocyte_physiolo4.72562586
5MP0005423_abnormal_somatic_nervous4.35056383
6MP0003880_abnormal_central_pattern4.29468746
7MP0002163_abnormal_gland_morphology4.07714658
8MP0005257_abnormal_intraocular_pressure3.18678179
9MP0002102_abnormal_ear_morphology2.98661483
10MP0003111_abnormal_nucleus_morphology2.95625292
11MP0003195_calcinosis2.76999028
12MP0005379_endocrine/exocrine_gland_phen2.63867521
13MP0003941_abnormal_skin_development2.50193798
14MP0000372_irregular_coat_pigmentation2.36635153
15MP0010094_abnormal_chromosome_stability2.35695650
16MP0003693_abnormal_embryo_hatching2.35655342
17MP0003077_abnormal_cell_cycle2.32226641
18MP0004381_abnormal_hair_follicle2.30284098
19MP0008995_early_reproductive_senescence2.27550457
20MP0008057_abnormal_DNA_replication2.22395009
21MP0003646_muscle_fatigue2.17231475
22MP0002089_abnormal_postnatal_growth/wei2.01860936
23MP0003950_abnormal_plasma_membrane1.96225613
24MP0000569_abnormal_digit_pigmentation1.94339616
25MP0002249_abnormal_larynx_morphology1.94295759
26MP0003183_abnormal_peptide_metabolism1.89491775
27MP0008932_abnormal_embryonic_tissue1.86029445
28MP0005499_abnormal_olfactory_system1.80838802
29MP0005394_taste/olfaction_phenotype1.80838802
30MP0001188_hyperpigmentation1.78750767
31MP0003943_abnormal_hepatobiliary_system1.77175573
32MP0004134_abnormal_chest_morphology1.75489146
33MP0005084_abnormal_gallbladder_morpholo1.73262806
34MP0002396_abnormal_hematopoietic_system1.73075317
35MP0008058_abnormal_DNA_repair1.70413237
36MP0005647_abnormal_sex_gland1.70127009
37MP0008961_abnormal_basal_metabolism1.64947545
38MP0001958_emphysema1.63587983
39MP0008004_abnormal_stomach_pH1.63047601
40MP0008007_abnormal_cellular_replicative1.61319541
41MP0001293_anophthalmia1.57316607
42MP0005220_abnormal_exocrine_pancreas1.56953710
43MP0000049_abnormal_middle_ear1.50761598
44MP0001929_abnormal_gametogenesis1.50133773
45MP0002138_abnormal_hepatobiliary_system1.47952538
46MP0005551_abnormal_eye_electrophysiolog1.42075847
47MP0002751_abnormal_autonomic_nervous1.38478809
48MP0006072_abnormal_retinal_apoptosis1.38335740
49MP0000490_abnormal_crypts_of1.36661132
50MP0003938_abnormal_ear_development1.36269639
51MP0003656_abnormal_erythrocyte_physiolo1.35073837
52MP0003786_premature_aging1.31584301
53MP0004957_abnormal_blastocyst_morpholog1.30840180
54MP0000685_abnormal_immune_system1.29719789
55MP0005410_abnormal_fertilization1.28918571
56MP0003252_abnormal_bile_duct1.27541079
57MP0002160_abnormal_reproductive_system1.25948003
58MP0000653_abnormal_sex_gland1.22372222
59MP0002210_abnormal_sex_determination1.21438280
60MP0005389_reproductive_system_phenotype1.20892392
61MP0000371_diluted_coat_color1.20258757
62MP0000350_abnormal_cell_proliferation1.20196822
63MP0005310_abnormal_salivary_gland1.20135885
64MP0008789_abnormal_olfactory_epithelium1.19646773
65MP0001119_abnormal_female_reproductive1.19593787
66MP0003119_abnormal_digestive_system1.19541419
67MP0002254_reproductive_system_inflammat1.14654837
68MP0005395_other_phenotype1.13568961
69MP0005253_abnormal_eye_physiology1.12425135
70MP0004264_abnormal_extraembryonic_tissu1.10966167
71MP0003699_abnormal_female_reproductive1.10906580
72MP0002332_abnormal_exercise_endurance1.10193338
73MP0000427_abnormal_hair_cycle1.09661554
74MP0000428_abnormal_craniofacial_morphol1.09172967
75MP0002928_abnormal_bile_duct1.07080146
76MP0005187_abnormal_penis_morphology1.05979509
77MP0003283_abnormal_digestive_organ1.05875333
78MP0001346_abnormal_lacrimal_gland1.05745955
79MP0002127_abnormal_cardiovascular_syste1.04597728
80MP0001984_abnormal_olfaction1.03165329
81MP0001145_abnormal_male_reproductive1.02493278
82MP0006276_abnormal_autonomic_nervous1.02025443
83MP0004133_heterotaxia0.95702749
84MP0005645_abnormal_hypothalamus_physiol0.95563686
85MP0000613_abnormal_salivary_gland0.94232669
86MP0001873_stomach_inflammation0.92823192
87MP0003698_abnormal_male_reproductive0.92069553
88MP0002092_abnormal_eye_morphology0.90889479
89MP0001919_abnormal_reproductive_system0.89290465
90MP0000689_abnormal_spleen_morphology0.89146946
91MP0001835_abnormal_antigen_presentation0.87423613
92MP0002075_abnormal_coat/hair_pigmentati0.87193058
93MP0000762_abnormal_tongue_morphology0.85573624
94MP0009697_abnormal_copulation0.85301941
95MP0004215_abnormal_myocardial_fiber0.84624855
96MP0008872_abnormal_physiological_respon0.84465996
97MP0006292_abnormal_olfactory_placode0.82734384
98MP0005266_abnormal_metabolism0.82665656
99MP0005174_abnormal_tail_pigmentation0.82537336
100MP0004808_abnormal_hematopoietic_stem0.82223630
101MP0001944_abnormal_pancreas_morphology0.81251618
102MP0001186_pigmentation_phenotype0.81134014
103MP0000313_abnormal_cell_death0.80708302
104MP0003984_embryonic_growth_retardation0.79311834
105MP0005671_abnormal_response_to0.79063425
106MP0002132_abnormal_respiratory_system0.78778393
107MP0003718_maternal_effect0.78087801
108MP0001986_abnormal_taste_sensitivity0.77503427
109MP0001672_abnormal_embryogenesis/_devel0.76515054
110MP0005380_embryogenesis_phenotype0.76515054
111MP0005075_abnormal_melanosome_morpholog0.76283646
112MP0001299_abnormal_eye_distance/0.75567800
113MP0001730_embryonic_growth_arrest0.75300492
114MP0003115_abnormal_respiratory_system0.74449450
115MP0002088_abnormal_embryonic_growth/wei0.74432488
116MP0001800_abnormal_humoral_immune0.73773234
117MP0003755_abnormal_palate_morphology0.73606981
118MP0002019_abnormal_tumor_incidence0.73118507
119MP0001286_abnormal_eye_development0.72420044
120MP0008877_abnormal_DNA_methylation0.71173249
121MP0002398_abnormal_bone_marrow0.70378247
122MP0001764_abnormal_homeostasis0.70144067
123MP0002277_abnormal_respiratory_mucosa0.69592285
124MP0005397_hematopoietic_system_phenotyp0.68075376
125MP0001545_abnormal_hematopoietic_system0.68075376
126MP0003937_abnormal_limbs/digits/tail_de0.67557442
127MP0002723_abnormal_immune_serum0.66999349
128MP0000015_abnormal_ear_pigmentation0.66582768
129MP0002452_abnormal_antigen_presenting0.65991153
130MP0003959_abnormal_lean_body0.65842986
131MP0002084_abnormal_developmental_patter0.64657109
132MP0001661_extended_life_span0.64282976
133MP0002161_abnormal_fertility/fecundity0.63851653
134MP0000703_abnormal_thymus_morphology0.63499643
135MP0003172_abnormal_lysosome_physiology0.63223804
136MP0003453_abnormal_keratinocyte_physiol0.62367066
137MP0003936_abnormal_reproductive_system0.62365092
138MP0002085_abnormal_embryonic_tissue0.62125842
139MP0001697_abnormal_embryo_size0.62047206
140MP0001324_abnormal_eye_pigmentation0.61838885
141MP0002086_abnormal_extraembryonic_tissu0.61531178
142MP0009278_abnormal_bone_marrow0.61508508
143MP0009053_abnormal_anal_canal0.61408896
144MP0003763_abnormal_thymus_physiology0.60862223
145MP0000647_abnormal_sebaceous_gland0.59226179
146MP0005508_abnormal_skeleton_morphology0.58648660
147MP0002111_abnormal_tail_morphology0.56409692
148MP0010307_abnormal_tumor_latency0.56012283
149MP0006054_spinal_hemorrhage0.55956857
150MP0009785_altered_susceptibility_to0.55553686
151MP0000858_altered_metastatic_potential0.55515788
152MP0000470_abnormal_stomach_morphology0.55487674
153MP0002722_abnormal_immune_system0.55229617
154MP0005646_abnormal_pituitary_gland0.55089768
155MP0002429_abnormal_blood_cell0.55010485
156MP0002938_white_spotting0.54839337
157MP0002419_abnormal_innate_immunity0.54459004
158MP0001819_abnormal_immune_cell0.53599031
159MP0002420_abnormal_adaptive_immunity0.53284329
160MP0000163_abnormal_cartilage_morphology0.52511498
161MP0000716_abnormal_immune_system0.52499478

Predicted human phenotypes

RankGene SetZ-score
1Neonatal short-limb short stature (HP:0008921)5.83784919
2Partial duplication of thumb phalanx (HP:0009944)5.63680390
3Partial duplication of the phalanx of hand (HP:0009999)4.90889259
4Duplication of thumb phalanx (HP:0009942)4.88372206
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.54173905
6Alacrima (HP:0000522)4.35897128
7Carpal bone hypoplasia (HP:0001498)4.32481452
8Aplasia involving bones of the upper limbs (HP:0009823)4.30535762
9Aplasia of the phalanges of the hand (HP:0009802)4.30535762
10Aplasia involving bones of the extremities (HP:0009825)4.30535762
11Chromsome breakage (HP:0040012)4.27850336
12Recurrent corneal erosions (HP:0000495)4.03396099
13Diastasis recti (HP:0001540)3.97377386
14Absent radius (HP:0003974)3.94933669
15Duplicated collecting system (HP:0000081)3.92347170
16Absent forearm bone (HP:0003953)3.81253542
17Aplasia involving forearm bones (HP:0009822)3.81253542
18Abnormality of incisor morphology (HP:0011063)3.79660462
19Decreased lacrimation (HP:0000633)3.74753919
20Abnormality of the costochondral junction (HP:0000919)3.67266853
21Aplasia/Hypoplasia of the fovea (HP:0008060)3.66665804
22Hypoplasia of the fovea (HP:0007750)3.66665804
23Xerostomia (HP:0000217)3.65950244
24Conical tooth (HP:0000698)3.58097538
25Aplasia cutis congenita (HP:0001057)3.57056834
26Coronal craniosynostosis (HP:0004440)3.48844389
27Abnormality of the renal collecting system (HP:0004742)3.48588164
28Nasolacrimal duct obstruction (HP:0000579)3.46979566
29Abnormality of the salivary glands (HP:0010286)3.36346365
30Neonatal death (HP:0003811)3.27649707
31Thickened helices (HP:0000391)3.22003718
32Abnormality of the right ventricle (HP:0001707)3.20071563
33Abnormality of abdominal situs (HP:0011620)3.17865031
34Abdominal situs inversus (HP:0003363)3.17865031
35Adactyly (HP:0009776)3.14228211
36Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.10417175
37Abnormality of the fovea (HP:0000493)3.09796683
38Leiomyosarcoma (HP:0100243)2.95626756
39Uterine leiomyosarcoma (HP:0002891)2.95626756
40Gonadal dysgenesis (HP:0000133)2.89687038
41Abnormality of the lumbar spine (HP:0100712)2.89310910
42Abnormality of the incisor (HP:0000676)2.86196818
43Abnormality of the antihelix (HP:0009738)2.84709419
44Agnosia (HP:0010524)2.78860215
45Heterotopia (HP:0002282)2.77822150
46Reticulocytopenia (HP:0001896)2.75417041
47Abnormality of the middle phalanges of the toes (HP:0010183)2.72538974
48Ectopic kidney (HP:0000086)2.71094210
49Lip pit (HP:0100267)2.71014866
50Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.70662945
51Albinism (HP:0001022)2.70218242
52Mixed hearing impairment (HP:0000410)2.69362560
53Megalencephaly (HP:0001355)2.66114771
54Triphalangeal thumb (HP:0001199)2.64619076
55Severe visual impairment (HP:0001141)2.64618687
56Short femoral neck (HP:0100864)2.60491793
57Abnormality of the ileum (HP:0001549)2.58270822
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.55206799
59Abnormality of the lacrimal duct (HP:0011481)2.54335961
60J-shaped sella turcica (HP:0002680)2.53554216
61Abnormality of the preputium (HP:0100587)2.53478545
62Aplasia/Hypoplasia of the scapulae (HP:0006713)2.51574337
63Hypoplastic scapulae (HP:0000882)2.51574337
64Abnormality of DNA repair (HP:0003254)2.49422980
65Aplasia/Hypoplasia of the macula (HP:0008059)2.48132335
66Abnormal pancreas size (HP:0012094)2.46934128
67Infantile muscular hypotonia (HP:0008947)2.46696238
68Intestinal atresia (HP:0011100)2.46635253
69Meckel diverticulum (HP:0002245)2.46074536
70Limited elbow extension (HP:0001377)2.44449359
71Thoracolumbar scoliosis (HP:0002944)2.43925128
72Double outlet right ventricle (HP:0001719)2.43053005
73Congenital malformation of the right heart (HP:0011723)2.43053005
74Gonadotropin excess (HP:0000837)2.41491158
75Increased nuchal translucency (HP:0010880)2.40527726
76Pancreatic cysts (HP:0001737)2.39964007
77Gaze-evoked nystagmus (HP:0000640)2.38104273
78Stomatitis (HP:0010280)2.37574383
79Oligodactyly (hands) (HP:0001180)2.35235139
80Anal stenosis (HP:0002025)2.34945801
81Abnormality of chromosome stability (HP:0003220)2.34557058
82Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.34448457
83Bile duct proliferation (HP:0001408)2.31344703
84Congenital stationary night blindness (HP:0007642)2.30624942
85Aplasia/Hypoplasia of the earlobes (HP:0009906)2.30309282
86Molar tooth sign on MRI (HP:0002419)2.29137440
87Abnormality of midbrain morphology (HP:0002418)2.29137440
88Transitional cell carcinoma of the bladder (HP:0006740)2.25631304
89Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.25413566
90Amelogenesis imperfecta (HP:0000705)2.24073669
91Flared metaphyses (HP:0003015)2.23294713
92Aplasia/Hypoplasia affecting the retina (HP:0008061)2.22859434
93Abnormality of permanent molar morphology (HP:0011071)2.20207336
94Abnormality of the dental root (HP:0006486)2.20207336
95Taurodontia (HP:0000679)2.20207336
96Abnormality of the nasolacrimal system (HP:0000614)2.19041872
97Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.17976462
98Fair hair (HP:0002286)2.17085065
99Gastrointestinal carcinoma (HP:0002672)2.14419068
100Malignant gastrointestinal tract tumors (HP:0006749)2.14419068
101Neoplasm of the adrenal cortex (HP:0100641)2.14052932
102Skull defect (HP:0001362)2.11997110
103Methylmalonic acidemia (HP:0002912)2.10836002
104Abnormality of molar (HP:0011077)2.09327440
105Abnormality of molar morphology (HP:0011070)2.09327440
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08986141
107Spinal canal stenosis (HP:0003416)2.08065762
108Duodenal stenosis (HP:0100867)2.07604814
109Small intestinal stenosis (HP:0012848)2.07604814
110Recurrent bronchitis (HP:0002837)2.06979063
111Degeneration of anterior horn cells (HP:0002398)2.06854220
112Abnormality of the anterior horn cell (HP:0006802)2.06854220
113Thyroiditis (HP:0100646)2.06781055
114Absent hand (HP:0004050)2.06350326
115Bifid scrotum (HP:0000048)2.05835582
116Aqueductal stenosis (HP:0002410)2.04606669
117Overfolded helix (HP:0000396)1.99722486
118Hypoplasia of the radius (HP:0002984)1.99325247
119Broad hallux (HP:0010055)1.99030486
120Polyuria (HP:0000103)1.98849342
121Increased number of teeth (HP:0011069)1.98318075
122Pancreatic fibrosis (HP:0100732)1.97451946
123Abnormality of glycolipid metabolism (HP:0010969)1.96937077
124Abnormality of liposaccharide metabolism (HP:0010968)1.96937077
125Abnormality of glycosphingolipid metabolism (HP:0004343)1.96937077
126Nephronophthisis (HP:0000090)1.95782298
127Pigmentary retinal degeneration (HP:0001146)1.95645094
128Preaxial hand polydactyly (HP:0001177)1.95367673
129Abnormality of pyrimidine metabolism (HP:0004353)1.95340869
130Volvulus (HP:0002580)1.94895395
131Preaxial foot polydactyly (HP:0001841)1.93442820
132Abnormality of the renal cortex (HP:0011035)1.93314318
133Clubbing of toes (HP:0100760)1.91981620
134Germ cell neoplasia (HP:0100728)1.91318075
135Synostosis of carpal bones (HP:0005048)1.91224720
136Chronic hepatic failure (HP:0100626)1.90988248
137Abnormality of the labia majora (HP:0012881)1.90389814
138Porencephaly (HP:0002132)1.89784194
139Hypoplastic iliac wings (HP:0002866)1.88775292
140Attenuation of retinal blood vessels (HP:0007843)1.87930177
141Septo-optic dysplasia (HP:0100842)1.87522106
142Abnormality of primary teeth (HP:0006481)1.87354611
143Abnormality of the dental pulp (HP:0006479)1.87272493
144Genetic anticipation (HP:0003743)1.87160304
145Abnormally folded helix (HP:0008544)1.86133199
146Bladder carcinoma (HP:0002862)1.85939821
147Bladder neoplasm (HP:0009725)1.85939821
148Renal agenesis (HP:0000104)1.85673586
149Broad alveolar ridges (HP:0000187)1.84546072
150Abnormal number of incisors (HP:0011064)1.84357752
151Aplasia/hypoplasia of the femur (HP:0005613)1.83443345
152Abnormality of the renal medulla (HP:0100957)1.83084772
153Abnormal biliary tract physiology (HP:0012439)1.83019660
154Asplenia (HP:0001746)1.80441486
155Hematochezia (HP:0002573)1.80002822
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.78416582
157Pancreatic islet-cell hyperplasia (HP:0004510)1.77955126
158Progressive inability to walk (HP:0002505)1.74932238
159Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74185407
160Flat acetabular roof (HP:0003180)1.73974207
161Slow saccadic eye movements (HP:0000514)1.72642257
162Retrobulbar optic neuritis (HP:0100654)1.72609654
163Optic neuritis (HP:0100653)1.72609654
164Abnormality of the odontoid process (HP:0003310)1.71619406
165Dyschromatopsia (HP:0007641)1.71324454
166Tubular atrophy (HP:0000092)1.70713678
167Abnormality of the sella turcica (HP:0002679)1.69840480
168Long clavicles (HP:0000890)1.69238122
169Aplasia/Hypoplasia of the tibia (HP:0005772)1.68830712
170Optic nerve hypoplasia (HP:0000609)1.68749988
171Tented upper lip vermilion (HP:0010804)1.68455788
172Vertebral arch anomaly (HP:0008438)1.68385800
173Growth hormone deficiency (HP:0000824)1.68215007
174Abnormality of the fetal cardiovascular system (HP:0010948)1.67053423
175Abnormal umbilical cord blood vessels (HP:0011403)1.67053423
176Single umbilical artery (HP:0001195)1.67053423
177Truncal obesity (HP:0001956)1.66713120
178Hyperventilation (HP:0002883)1.66411002
179Stomach cancer (HP:0012126)1.65877299
180Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.64689701
181Abnormality of B cell number (HP:0010975)1.64385014
182Sloping forehead (HP:0000340)1.61311920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB19.61597952
2FRK5.64078763
3BLK4.64610407
4ACVR1B4.04740340
5FGFR33.99517752
6CDK83.97792615
7SIK32.64695661
8TLK12.60982982
9MST42.47157021
10BMPR1B2.44285516
11CDK122.33033708
12NEK22.21352268
13TRIM282.13404734
14ZAK2.10055582
15MAP4K21.97378308
16TGFBR21.94764897
17FGFR11.90454179
18TXK1.82537862
19CDC71.78143609
20TAOK31.75194728
21TTK1.73734475
22SRPK11.68342592
23DYRK31.67797759
24BRD41.67385765
25STK38L1.62832824
26ATR1.61495458
27STK161.59509623
28WNK31.54974773
29MELK1.50455789
30EPHA21.43637444
31WEE11.38749506
32IRAK21.38625941
33ERBB41.38039770
34GRK71.37887762
35VRK11.35185974
36IRAK11.34074160
37CDK41.32953423
38PLK21.31926020
39PLK11.25495217
40INSRR1.24119100
41RPS6KA41.22374210
42CAMK1G1.19753412
43EIF2AK11.19315290
44MKNK21.19098455
45NTRK21.17972668
46CHEK21.13119947
47MAP3K41.13088436
48CDK71.10588444
49CDK91.08895636
50IRAK31.06652640
51AURKB1.05670937
52TGFBR11.04160116
53YES11.04141663
54STK41.03757974
55PAK41.03356208
56SIK21.02626522
57BRSK11.02456101
58BRSK20.97377042
59GRK10.95238342
60TNK20.93420402
61MKNK10.93003865
62GRK50.91687644
63CAMKK20.91596000
64MOS0.89262095
65MAP3K140.87828968
66AKT30.87528746
67MAP3K100.87394144
68CHEK10.85148788
69PTK2B0.80918886
70KIT0.80648076
71MAP4K10.79834163
72TEC0.79040931
73TSSK60.78763379
74ADRBK10.78559885
75AKT20.74862502
76PKN20.74675549
77CASK0.74197775
78MAP3K130.74073280
79PLK40.74059448
80SYK0.73093846
81PIK3CG0.72968168
82AURKA0.71695441
83MAP2K30.70239528
84PRPF4B0.69905185
85EIF2AK20.67940161
86PDK20.65479554
87STK240.65087852
88SCYL20.64544013
89CAMK40.64474808
90CHUK0.62966702
91MAP3K60.61837270
92NUAK10.61190957
93SGK20.59735503
94NLK0.59315597
95STK100.58562522
96CCNB10.58353941
97LATS10.58109442
98FLT30.57947374
99PIM10.57303459
100IKBKB0.56664495
101SIK10.56506138
102RPS6KB20.55383282
103HIPK20.54295418
104STK380.53353023
105MARK30.53237198
106CDK20.53094927
107PASK0.53058356
108WNK10.53032280
109MAP3K70.52492455
110ADRBK20.51543733
111OXSR10.51042280
112UHMK10.50855816
113BMPR20.50712063
114RAF10.50301212
115FGFR20.50292260
116MAPK130.49604347
117PRKCZ0.49097412
118STK390.49027489
119PRKCQ0.48617319
120IRAK40.48419889
121EIF2AK30.47994180
122ATM0.47598769
123EEF2K0.47572177
124TYK20.47325921
125NEK60.47152097
126STK30.46599044
127CSNK1G10.43926050
128PRKAA20.43787846
129LYN0.43588301
130BTK0.43182105
131PLK30.42545844
132TRPM70.41775396
133CSF1R0.39773878
134CDK10.38790191
135TNIK0.38154225
136MAP2K40.37102246
137CSNK1D0.36315469
138CAMK1D0.36151445
139PBK0.36084521
140MTOR0.35278582
141FGR0.34655572
142STK110.34577136
143MAPK110.34139233
144ZAP700.33741879
145MAP3K80.33615180
146OBSCN0.32781586
147IKBKE0.32287778
148CLK10.31448399
149CSK0.30373625
150MAPK90.28847446
151RIPK10.28111553
152MAPK100.27608618
153NME20.27244962
154ROCK20.25925600
155GRK60.24151751
156RPS6KA50.24033580
157JAK30.22730392
158CSNK2A20.22591820
159CSNK2A10.19721047

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61269770
2Base excision repair_Homo sapiens_hsa034104.14246479
3Mismatch repair_Homo sapiens_hsa034303.63065335
4Notch signaling pathway_Homo sapiens_hsa043302.94374631
5Fanconi anemia pathway_Homo sapiens_hsa034602.77950231
6Spliceosome_Homo sapiens_hsa030402.73069373
7Olfactory transduction_Homo sapiens_hsa047402.66336765
8Homologous recombination_Homo sapiens_hsa034402.60569221
9Ovarian steroidogenesis_Homo sapiens_hsa049132.60415962
10Cell cycle_Homo sapiens_hsa041102.56049608
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43743698
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40464707
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.32073462
14RNA transport_Homo sapiens_hsa030132.29387518
15Non-homologous end-joining_Homo sapiens_hsa034502.17469479
16Nucleotide excision repair_Homo sapiens_hsa034202.09018806
17Systemic lupus erythematosus_Homo sapiens_hsa053222.08368779
18One carbon pool by folate_Homo sapiens_hsa006702.06467745
19Circadian rhythm_Homo sapiens_hsa047101.91574578
20Basal cell carcinoma_Homo sapiens_hsa052171.85619338
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.74579485
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71571536
23Pyrimidine metabolism_Homo sapiens_hsa002401.54985509
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54895711
25p53 signaling pathway_Homo sapiens_hsa041151.45129551
26Hedgehog signaling pathway_Homo sapiens_hsa043401.44501283
27Phototransduction_Homo sapiens_hsa047441.42747901
28MicroRNAs in cancer_Homo sapiens_hsa052061.39863224
29mRNA surveillance pathway_Homo sapiens_hsa030151.39068117
30RNA polymerase_Homo sapiens_hsa030201.38271593
31Caffeine metabolism_Homo sapiens_hsa002321.37068826
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36658415
33RNA degradation_Homo sapiens_hsa030181.34328691
34Basal transcription factors_Homo sapiens_hsa030221.33073528
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.30985269
36Bladder cancer_Homo sapiens_hsa052191.27065891
37Sulfur metabolism_Homo sapiens_hsa009201.25683842
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.25446370
39ABC transporters_Homo sapiens_hsa020101.23725802
40HTLV-I infection_Homo sapiens_hsa051661.19934985
41Herpes simplex infection_Homo sapiens_hsa051681.19779749
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17387847
43FoxO signaling pathway_Homo sapiens_hsa040681.15613991
44Viral carcinogenesis_Homo sapiens_hsa052031.15257067
45Butanoate metabolism_Homo sapiens_hsa006501.13595693
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.09311229
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08744777
48Ether lipid metabolism_Homo sapiens_hsa005651.08093326
49Inositol phosphate metabolism_Homo sapiens_hsa005621.06443029
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06043652
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05793622
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04808751
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04519239
54Measles_Homo sapiens_hsa051621.04318536
55Taste transduction_Homo sapiens_hsa047421.03826365
56Platelet activation_Homo sapiens_hsa046111.02104622
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01133011
58Regulation of autophagy_Homo sapiens_hsa041400.99234748
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95564373
60Leishmaniasis_Homo sapiens_hsa051400.95181129
61Vitamin B6 metabolism_Homo sapiens_hsa007500.95164630
62Dorso-ventral axis formation_Homo sapiens_hsa043200.94984671
63Apoptosis_Homo sapiens_hsa042100.94341083
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93722076
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93197041
66Hematopoietic cell lineage_Homo sapiens_hsa046400.91960300
67Primary immunodeficiency_Homo sapiens_hsa053400.86986660
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86716796
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85942570
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85207654
71Proteasome_Homo sapiens_hsa030500.85109083
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.84550392
73Linoleic acid metabolism_Homo sapiens_hsa005910.82520420
74Epstein-Barr virus infection_Homo sapiens_hsa051690.82400992
75N-Glycan biosynthesis_Homo sapiens_hsa005100.80396472
76Propanoate metabolism_Homo sapiens_hsa006400.79591219
77Calcium signaling pathway_Homo sapiens_hsa040200.79561607
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78675033
79Ribosome_Homo sapiens_hsa030100.78248822
80Small cell lung cancer_Homo sapiens_hsa052220.75944594
81Allograft rejection_Homo sapiens_hsa053300.74583242
82Purine metabolism_Homo sapiens_hsa002300.74272927
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73775566
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72640623
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72511333
86Hepatitis B_Homo sapiens_hsa051610.71472426
87Folate biosynthesis_Homo sapiens_hsa007900.70686762
88Asthma_Homo sapiens_hsa053100.68832711
89Tryptophan metabolism_Homo sapiens_hsa003800.68714081
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.68459731
91Chronic myeloid leukemia_Homo sapiens_hsa052200.67612123
92Antigen processing and presentation_Homo sapiens_hsa046120.66730139
93Influenza A_Homo sapiens_hsa051640.66350886
94Melanoma_Homo sapiens_hsa052180.64428432
95Prostate cancer_Homo sapiens_hsa052150.64356617
96Retinol metabolism_Homo sapiens_hsa008300.64230017
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60146296
98Pathways in cancer_Homo sapiens_hsa052000.59409882
99cAMP signaling pathway_Homo sapiens_hsa040240.59374843
100Alcoholism_Homo sapiens_hsa050340.57726724
101Legionellosis_Homo sapiens_hsa051340.56637166
102Salivary secretion_Homo sapiens_hsa049700.56222770
103Selenocompound metabolism_Homo sapiens_hsa004500.54056322
104Hippo signaling pathway_Homo sapiens_hsa043900.53892889
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53600110
106Shigellosis_Homo sapiens_hsa051310.52808068
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52016143
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52009348
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51700424
110Colorectal cancer_Homo sapiens_hsa052100.51236534
111Non-small cell lung cancer_Homo sapiens_hsa052230.50091365
112Type I diabetes mellitus_Homo sapiens_hsa049400.49448385
113Chemokine signaling pathway_Homo sapiens_hsa040620.48836479
114Fructose and mannose metabolism_Homo sapiens_hsa000510.48695761
115Tuberculosis_Homo sapiens_hsa051520.48606573
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48503558
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48071641
118Pancreatic cancer_Homo sapiens_hsa052120.47482119
119Lysine degradation_Homo sapiens_hsa003100.47430346
120Prion diseases_Homo sapiens_hsa050200.46998820
121Type II diabetes mellitus_Homo sapiens_hsa049300.45519064
122Steroid biosynthesis_Homo sapiens_hsa001000.45334486
123mTOR signaling pathway_Homo sapiens_hsa041500.43601342
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43492750
125Morphine addiction_Homo sapiens_hsa050320.43435035
126Graft-versus-host disease_Homo sapiens_hsa053320.43286393
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.42920575
128Wnt signaling pathway_Homo sapiens_hsa043100.42589410
129Pentose phosphate pathway_Homo sapiens_hsa000300.42431513
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41926650
131Sulfur relay system_Homo sapiens_hsa041220.41603125
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.40357374
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39575046
134Protein export_Homo sapiens_hsa030600.39073775
135Osteoclast differentiation_Homo sapiens_hsa043800.37847723
136B cell receptor signaling pathway_Homo sapiens_hsa046620.36315564
137TNF signaling pathway_Homo sapiens_hsa046680.35370919
138Autoimmune thyroid disease_Homo sapiens_hsa053200.35295720
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.35078138
140Acute myeloid leukemia_Homo sapiens_hsa052210.34740113
141Malaria_Homo sapiens_hsa051440.33522710
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33441127
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33219221
144Other glycan degradation_Homo sapiens_hsa005110.32840956
145T cell receptor signaling pathway_Homo sapiens_hsa046600.32486087
146Oocyte meiosis_Homo sapiens_hsa041140.31238797
147Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31065331
148TGF-beta signaling pathway_Homo sapiens_hsa043500.31056901

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »