TRMT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)7.58853565
2acrosome reaction (GO:0007340)6.85150169
3rRNA methylation (GO:0031167)6.72355904
4chromosome condensation (GO:0030261)6.65100973
5fusion of sperm to egg plasma membrane (GO:0007342)6.53582772
6microtubule depolymerization (GO:0007019)6.44991943
7DNA packaging (GO:0006323)6.41938267
8centriole replication (GO:0007099)5.88024616
9single strand break repair (GO:0000012)5.77802519
10microtubule polymerization or depolymerization (GO:0031109)5.63860053
11protein polyglutamylation (GO:0018095)5.56719340
12spermatid development (GO:0007286)5.39167020
13sperm-egg recognition (GO:0035036)5.29416408
14binding of sperm to zona pellucida (GO:0007339)5.22370213
15spermatid nucleus differentiation (GO:0007289)5.15632304
16purine nucleobase biosynthetic process (GO:0009113)4.87586944
17plasma membrane fusion (GO:0045026)4.86138962
18protein targeting to Golgi (GO:0000042)4.85159185
19centriole assembly (GO:0098534)4.82216574
20DNA strand elongation involved in DNA replication (GO:0006271)4.76985807
21nucleobase biosynthetic process (GO:0046112)4.71953809
22establishment of protein localization to Golgi (GO:0072600)4.68938884
23sperm capacitation (GO:0048240)4.60541141
24DNA replication initiation (GO:0006270)4.60282597
25response to pheromone (GO:0019236)4.55062547
26DNA strand elongation (GO:0022616)4.51872708
27spermatogenesis (GO:0007283)4.50310651
28male gamete generation (GO:0048232)4.50294274
29telomere maintenance via semi-conservative replication (GO:0032201)4.46120501
30retrograde transport, vesicle recycling within Golgi (GO:0000301)4.45572091
31formation of translation preinitiation complex (GO:0001731)4.30864070
32CENP-A containing nucleosome assembly (GO:0034080)4.27545361
33ribosome assembly (GO:0042255)4.26491673
34gamete generation (GO:0007276)4.22874304
35multicellular organism reproduction (GO:0032504)4.21350879
36ribosome biogenesis (GO:0042254)4.18434693
37chromatin remodeling at centromere (GO:0031055)4.16292726
38IMP biosynthetic process (GO:0006188)4.14368278
39cell-cell recognition (GO:0009988)4.11789832
40nuclear pore organization (GO:0006999)4.11786235
41mitotic metaphase plate congression (GO:0007080)4.05967031
42maturation of SSU-rRNA (GO:0030490)4.05782610
43DNA replication checkpoint (GO:0000076)4.04916857
44seminiferous tubule development (GO:0072520)4.04557835
45telomere maintenance via recombination (GO:0000722)4.02314712
46regulation of cilium movement (GO:0003352)4.01236347
47microtubule severing (GO:0051013)3.96197686
48DNA unwinding involved in DNA replication (GO:0006268)3.93348661
49IMP metabolic process (GO:0046040)3.90010803
50mitotic nuclear envelope disassembly (GO:0007077)3.89788710
51DNA replication-independent nucleosome assembly (GO:0006336)3.88169166
52DNA replication-independent nucleosome organization (GO:0034724)3.88169166
53regulation of spindle organization (GO:0090224)3.84431428
54axonemal dynein complex assembly (GO:0070286)3.81235567
55nuclear pore complex assembly (GO:0051292)3.80383394
56mitotic recombination (GO:0006312)3.77025532
57protein localization to kinetochore (GO:0034501)3.71723494
58folic acid-containing compound biosynthetic process (GO:0009396)3.65695719
59regulation of centrosome duplication (GO:0010824)3.65147411
60attachment of spindle microtubules to kinetochore (GO:0008608)3.65024061
61kinetochore organization (GO:0051383)3.63158990
62histone exchange (GO:0043486)3.61259096
63ribonucleoprotein complex biogenesis (GO:0022613)3.59714630
64membrane disassembly (GO:0030397)3.58519922
65nuclear envelope disassembly (GO:0051081)3.58519922
66single fertilization (GO:0007338)3.58468283
67proteasome assembly (GO:0043248)3.55399088
68synapsis (GO:0007129)3.54386627
69protein localization to Golgi apparatus (GO:0034067)3.52480478
70telomere maintenance via telomere lengthening (GO:0010833)3.52285043
71calcium ion-dependent exocytosis (GO:0017156)3.50685655
72metaphase plate congression (GO:0051310)3.50679693
73reproduction (GO:0000003)3.50233747
74nucleus organization (GO:0006997)3.47512446
75nucleotide-excision repair, DNA gap filling (GO:0006297)3.45144671
76ribosomal small subunit assembly (GO:0000028)3.44093231
77pseudouridine synthesis (GO:0001522)3.42563663
78kinetochore assembly (GO:0051382)3.42385123
79glycerol ether metabolic process (GO:0006662)3.41220561
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39498471
81DNA replication-dependent nucleosome organization (GO:0034723)3.38069636
82DNA replication-dependent nucleosome assembly (GO:0006335)3.38069636
83phosphatidylethanolamine biosynthetic process (GO:0006646)3.35517170
84DNA deamination (GO:0045006)3.33872198
85regulation of meiosis I (GO:0060631)3.33377005
86fertilization (GO:0009566)3.32886848
87multicellular organismal reproductive process (GO:0048609)3.32041376
88piRNA metabolic process (GO:0034587)3.30164412
89ribosomal large subunit biogenesis (GO:0042273)3.28888014
90somatic hypermutation of immunoglobulin genes (GO:0016446)3.28146613
91somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28146613
92germ cell development (GO:0007281)3.27936583
93DNA conformation change (GO:0071103)3.27758906
94rRNA modification (GO:0000154)3.26940744
95glomerular visceral epithelial cell development (GO:0072015)3.25813817
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.25203101
97resolution of meiotic recombination intermediates (GO:0000712)3.24856466
98spliceosomal snRNP assembly (GO:0000387)3.23640945
99meiotic chromosome segregation (GO:0045132)3.23412362
100pore complex assembly (GO:0046931)3.20273893
101cellular ketone body metabolic process (GO:0046950)3.18369070
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18235012
103ether metabolic process (GO:0018904)3.17222056
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16991532
105folic acid metabolic process (GO:0046655)3.16264246
106epithelial cilium movement (GO:0003351)3.16096024
107negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15927265
108postreplication repair (GO:0006301)3.15703980
109phosphatidylethanolamine metabolic process (GO:0046337)3.15343050
110protein localization to chromosome, centromeric region (GO:0071459)3.14687960
111cell cycle G1/S phase transition (GO:0044843)3.13797564
112G1/S transition of mitotic cell cycle (GO:0000082)3.13797564
113replication fork processing (GO:0031297)3.13289562
114transcription-coupled nucleotide-excision repair (GO:0006283)3.12361574
115non-recombinational repair (GO:0000726)3.10699455
116double-strand break repair via nonhomologous end joining (GO:0006303)3.10699455
117rRNA processing (GO:0006364)3.10667782
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10619000
119microtubule nucleation (GO:0007020)3.08679069
120protein K6-linked ubiquitination (GO:0085020)3.05049309
121rRNA metabolic process (GO:0016072)3.02300217
122cellular process involved in reproduction in multicellular organism (GO:0022412)3.02230441
123establishment of chromosome localization (GO:0051303)3.02174362
124DNA ligation (GO:0006266)3.01173191
125ketone body metabolic process (GO:1902224)3.01144014
126motile cilium assembly (GO:0044458)2.98017974
127male meiosis I (GO:0007141)2.94668966
128regulation of chromosome segregation (GO:0051983)2.93824767
129mitotic chromosome condensation (GO:0007076)2.92407488
130cell wall macromolecule catabolic process (GO:0016998)2.92236739
131double-strand break repair via homologous recombination (GO:0000724)2.91219458
132recombinational repair (GO:0000725)2.90753927
133glomerular epithelial cell development (GO:0072310)2.90529226
134male meiosis (GO:0007140)2.90527201
135maturation of 5.8S rRNA (GO:0000460)2.90105031
136regulation of translation in response to stress (GO:0043555)2.87876940
137DNA methylation involved in gamete generation (GO:0043046)2.87107097
138regulation of centrosome cycle (GO:0046605)2.86198141
139negative regulation of ligase activity (GO:0051352)2.84846469
140negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.84846469
141DNA geometric change (GO:0032392)2.84764686
142DNA duplex unwinding (GO:0032508)2.84683927
143cilium or flagellum-dependent cell motility (GO:0001539)2.84156839
144translational initiation (GO:0006413)2.83702216
145monoubiquitinated protein deubiquitination (GO:0035520)2.83336180
146deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82895856
147spindle checkpoint (GO:0031577)2.82892676
148cellular component biogenesis (GO:0044085)2.82798221
149mitochondrial RNA metabolic process (GO:0000959)2.82369193
150positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82213761
151regulation of mitotic spindle organization (GO:0060236)2.82090982
152cell wall macromolecule metabolic process (GO:0044036)2.81883392
153mitochondrial DNA replication (GO:0006264)2.81724196
154DNA double-strand break processing (GO:0000729)2.81550039
155regulation of centriole replication (GO:0046599)2.81518442
156negative regulation of mitotic sister chromatid separation (GO:2000816)2.79755989
157negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79755989
158negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79755989
159negative regulation of sister chromatid segregation (GO:0033046)2.79755989
160oxidative phosphorylation (GO:0006119)2.79293722
161negative regulation of chromosome segregation (GO:0051985)2.78973458
162regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.78232721
163meiotic cell cycle process (GO:1903046)2.78228589
164sister chromatid cohesion (GO:0007062)2.77965141
165deoxyribonucleotide biosynthetic process (GO:0009263)2.77125505
166chromatin assembly or disassembly (GO:0006333)2.76683615
167DNA synthesis involved in DNA repair (GO:0000731)2.76174056
1687-methylguanosine mRNA capping (GO:0006370)2.75850816
169nuclear envelope organization (GO:0006998)2.75598381
170centrosome duplication (GO:0051298)2.75241645
171regulation of double-strand break repair via homologous recombination (GO:0010569)2.74799301
172establishment of integrated proviral latency (GO:0075713)2.74458196
173telomere maintenance (GO:0000723)2.74446742
174negative regulation of DNA-dependent DNA replication (GO:2000104)2.74097637
175telomere organization (GO:0032200)2.74035698
1767-methylguanosine RNA capping (GO:0009452)2.73433226
177mitochondrial fission (GO:0000266)2.73203339
178histone mRNA metabolic process (GO:0008334)2.69243354
179positive regulation of chromosome segregation (GO:0051984)2.69048136
180mitotic G2/M transition checkpoint (GO:0044818)2.68043306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.04149561
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.55284515
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62082005
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43591048
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40519563
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.22332869
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.17551776
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05674600
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.04152304
10FUS_26573619_Chip-Seq_HEK293_Human3.02224806
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97445304
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94383836
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.92413103
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91334453
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86828495
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83348667
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81629865
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.56102070
19ZNF274_21170338_ChIP-Seq_K562_Hela2.55505517
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48185123
21AR_21909140_ChIP-Seq_LNCAP_Human2.43170571
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40249863
23VDR_23849224_ChIP-Seq_CD4+_Human2.32221061
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32058559
25XRN2_22483619_ChIP-Seq_HELA_Human2.27319362
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20580816
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17507602
28DCP1A_22483619_ChIP-Seq_HELA_Human2.11276541
29FOXP3_21729870_ChIP-Seq_TREG_Human2.06080014
30MYCN_18555785_ChIP-Seq_MESCs_Mouse2.03525604
31* IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.03225312
32* CBP_20019798_ChIP-Seq_JUKART_Human2.03225312
33E2F1_21310950_ChIP-Seq_MCF-7_Human2.01762354
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98142090
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97351065
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97092289
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96249310
38GABP_19822575_ChIP-Seq_HepG2_Human1.91952264
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90280270
40P300_19829295_ChIP-Seq_ESCs_Human1.89039156
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86584986
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86045636
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85910638
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83982451
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80019271
46VDR_22108803_ChIP-Seq_LS180_Human1.79913300
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79460240
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79102175
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.78460785
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77859751
51TTF2_22483619_ChIP-Seq_HELA_Human1.76884979
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76149257
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75958632
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71606607
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71606607
56ELK1_19687146_ChIP-ChIP_HELA_Human1.70902692
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68683186
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.67659264
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67433688
60TAF15_26573619_Chip-Seq_HEK293_Human1.65282797
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65117278
62ER_23166858_ChIP-Seq_MCF-7_Human1.64857625
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.63392785
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61967745
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61824683
66EWS_26573619_Chip-Seq_HEK293_Human1.61609565
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57781998
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56127714
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55241144
70KDM5A_27292631_Chip-Seq_BREAST_Human1.52841466
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50612941
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49794740
73* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48188647
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45473458
75CIITA_25753668_ChIP-Seq_RAJI_Human1.43916330
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37404323
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36413793
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.36110873
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35947414
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.34651287
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.34000466
82MYC_22102868_ChIP-Seq_BL_Human1.30963222
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30055959
84AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28888425
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28702970
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28124884
87IGF1R_20145208_ChIP-Seq_DFB_Human1.27994988
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27588271
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27008232
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.26722874
91RBPJ_21746931_ChIP-Seq_IB4_Human1.26459995
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25502678
93AR_25329375_ChIP-Seq_VCAP_Human1.24875245
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23540289
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23338208
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22616733
97CBX2_22325352_ChIP-Seq_293T-Rex_Human1.21285074
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21162231
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18831236
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18805903
101ETV1_20927104_ChIP-Seq_GIST48_Human1.18102539
102SMAD4_21799915_ChIP-Seq_A2780_Human1.17553901
103TFEB_21752829_ChIP-Seq_HELA_Human1.16921869
104HNFA_21074721_ChIP-Seq_CACO-2_Human1.16076054
105SALL4_22934838_ChIP-ChIP_CD34+_Human1.15130146
106PHF8_20622853_ChIP-Seq_HELA_Human1.13656823
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13574348
108NFYB_21822215_ChIP-Seq_K562_Human1.13567218
109CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.13343353
110SOX2_19829295_ChIP-Seq_ESCs_Human1.13101198
111NANOG_19829295_ChIP-Seq_ESCs_Human1.13101198
112* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11580219
113STAT3_23295773_ChIP-Seq_U87_Human1.11484185
114TP53_18474530_ChIP-ChIP_U2OS_Human1.10394334
115PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10186583
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07999749
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07872884
118GBX2_23144817_ChIP-Seq_PC3_Human1.06860950
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04726321
120ERG_20517297_ChIP-Seq_VCAP_Human1.04382569
121SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03613238
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03241483
123TBL1_22424771_ChIP-Seq_293T_Human1.01088707
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00558976
125TP63_19390658_ChIP-ChIP_HaCaT_Human1.00336985
126HOXB7_26014856_ChIP-Seq_BT474_Human1.00326021
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00290613
128FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99680487
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98157525
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97805170
131PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97189090
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95839498
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95334224
134ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94237403
135FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94019316
136FOXA1_25329375_ChIP-Seq_VCAP_Human0.94019316
137RUNX2_22187159_ChIP-Seq_PCA_Human0.93255734
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.93206641
139MYC_18940864_ChIP-ChIP_HL60_Human0.92972068
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.92660959
141GATA6_21074721_ChIP-Seq_CACO-2_Human0.92500127
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90876786
143SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89658513
144GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88903293
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88856358
146* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88752305
147KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88283907
148SALL1_21062744_ChIP-ChIP_HESCs_Human0.86876442
149SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86134029
150NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84167137
151* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84077512
152SPI1_23547873_ChIP-Seq_NB4_Human0.81496499
153ELK1_22589737_ChIP-Seq_MCF10A_Human0.80900002
154DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80662553
155CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80442564
156CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79062033
157NANOG_21062744_ChIP-ChIP_HESCs_Human0.78036686
158NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77731791
159OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76599963
160TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76117463
161SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76065227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.41228527
2MP0003693_abnormal_embryo_hatching5.80983263
3MP0010094_abnormal_chromosome_stability4.36608827
4MP0004957_abnormal_blastocyst_morpholog3.99814375
5MP0003111_abnormal_nucleus_morphology3.87253209
6MP0003077_abnormal_cell_cycle3.77933961
7MP0008058_abnormal_DNA_repair3.65156983
8MP0008057_abnormal_DNA_replication3.17079205
9MP0003698_abnormal_male_reproductive3.16520166
10MP0005377_hearing/vestibular/ear_phenot3.12246253
11MP0003878_abnormal_ear_physiology3.12246253
12MP0003646_muscle_fatigue2.80733663
13MP0008877_abnormal_DNA_methylation2.75110937
14MP0003806_abnormal_nucleotide_metabolis2.74676452
15MP0008932_abnormal_embryonic_tissue2.55459186
16MP0008007_abnormal_cellular_replicative2.43106289
17MP0002396_abnormal_hematopoietic_system2.37533292
18MP0001730_embryonic_growth_arrest2.30142557
19MP0005670_abnormal_white_adipose2.26682469
20MP0004084_abnormal_cardiac_muscle2.16529563
21MP0003123_paternal_imprinting2.09807473
22MP0008789_abnormal_olfactory_epithelium2.08200336
23MP0000350_abnormal_cell_proliferation1.93608627
24MP0002161_abnormal_fertility/fecundity1.86228028
25MP0005380_embryogenesis_phenotype1.85579109
26MP0001672_abnormal_embryogenesis/_devel1.85579109
27MP0003567_abnormal_fetal_cardiomyocyte1.82761130
28MP0003984_embryonic_growth_retardation1.77466777
29MP0003011_delayed_dark_adaptation1.75278793
30MP0005379_endocrine/exocrine_gland_phen1.71936511
31MP0002088_abnormal_embryonic_growth/wei1.71614977
32MP0001697_abnormal_embryo_size1.71494902
33MP0010352_gastrointestinal_tract_polyps1.71009535
34MP0000372_irregular_coat_pigmentation1.69780936
35MP0003786_premature_aging1.65748670
36MP0006036_abnormal_mitochondrial_physio1.60671126
37MP0003950_abnormal_plasma_membrane1.56876128
38MP0002080_prenatal_lethality1.56453560
39MP0005253_abnormal_eye_physiology1.55056799
40MP0003718_maternal_effect1.53203741
41MP0004808_abnormal_hematopoietic_stem1.52896204
42MP0010307_abnormal_tumor_latency1.44635962
43MP0003221_abnormal_cardiomyocyte_apopto1.44562674
44MP0001485_abnormal_pinna_reflex1.43329458
45MP0002938_white_spotting1.40827646
46MP0005394_taste/olfaction_phenotype1.40596185
47MP0005499_abnormal_olfactory_system1.40596185
48MP0001348_abnormal_lacrimal_gland1.40372331
49MP0004215_abnormal_myocardial_fiber1.39363355
50MP0003186_abnormal_redox_activity1.39044387
51MP0005408_hypopigmentation1.32182907
52MP0005395_other_phenotype1.31913860
53MP0002019_abnormal_tumor_incidence1.31379657
54MP0002837_dystrophic_cardiac_calcinosis1.31165281
55MP0000313_abnormal_cell_death1.30357598
56MP0004233_abnormal_muscle_weight1.28695680
57MP0002085_abnormal_embryonic_tissue1.28349763
58MP0002269_muscular_atrophy1.27170897
59MP0002086_abnormal_extraembryonic_tissu1.25738878
60MP0002160_abnormal_reproductive_system1.25337007
61MP0002210_abnormal_sex_determination1.24593346
62MP0002102_abnormal_ear_morphology1.24547386
63MP0004197_abnormal_fetal_growth/weight/1.23246140
64MP0005551_abnormal_eye_electrophysiolog1.21278928
65MP0002084_abnormal_developmental_patter1.20202534
66MP0000490_abnormal_crypts_of1.13855311
67MP0005330_cardiomyopathy1.13741481
68MP0005266_abnormal_metabolism1.12402760
69MP0000358_abnormal_cell_content/1.12206205
70MP0001984_abnormal_olfaction1.11049611
71MP0006035_abnormal_mitochondrial_morpho1.10916522
72MP0001853_heart_inflammation1.09665072
73MP0010030_abnormal_orbit_morphology1.08435443
74MP0009697_abnormal_copulation1.07487746
75MP0001929_abnormal_gametogenesis1.07349815
76MP0001145_abnormal_male_reproductive1.06490676
77MP0005391_vision/eye_phenotype1.06432495
78MP0005248_abnormal_Harderian_gland1.05142007
79MP0001545_abnormal_hematopoietic_system1.04305480
80MP0005397_hematopoietic_system_phenotyp1.04305480
81MP0002282_abnormal_trachea_morphology1.03704536
82MP0003136_yellow_coat_color1.03446247
83MP0006072_abnormal_retinal_apoptosis1.02859828
84MP0003119_abnormal_digestive_system1.01870345
85MP0010630_abnormal_cardiac_muscle1.01259440
86MP0000049_abnormal_middle_ear1.00907859
87MP0004147_increased_porphyrin_level1.00212644
88MP0005367_renal/urinary_system_phenotyp0.99663619
89MP0000516_abnormal_urinary_system0.99663619
90MP0003937_abnormal_limbs/digits/tail_de0.97798809
91MP0000653_abnormal_sex_gland0.96597051
92MP0009672_abnormal_birth_weight0.96398308
93MP0002233_abnormal_nose_morphology0.95326241
94MP0001544_abnormal_cardiovascular_syste0.94554790
95MP0005385_cardiovascular_system_phenoty0.94554790
96MP0003890_abnormal_embryonic-extraembry0.93973827
97MP0003315_abnormal_perineum_morphology0.93862314
98MP0009333_abnormal_splenocyte_physiolog0.93172670
99MP0004036_abnormal_muscle_relaxation0.91212365
100MP0000749_muscle_degeneration0.89992390
101MP0000750_abnormal_muscle_regeneration0.89460080
102MP0000678_abnormal_parathyroid_gland0.87411339
103MP0006138_congestive_heart_failure0.84166496
104MP0005310_abnormal_salivary_gland0.83745297
105MP0000703_abnormal_thymus_morphology0.81673458
106MP0003941_abnormal_skin_development0.81283438
107MP0002722_abnormal_immune_system0.80508080
108MP0000689_abnormal_spleen_morphology0.80344792
109MP0001119_abnormal_female_reproductive0.79966199
110MP0001293_anophthalmia0.79397998
111MP0002234_abnormal_pharynx_morphology0.79182403
112MP0003828_pulmonary_edema0.78261356
113MP0002398_abnormal_bone_marrow0.78261307
114MP0003121_genomic_imprinting0.77290629
115MP0003763_abnormal_thymus_physiology0.76514149
116MP0003755_abnormal_palate_morphology0.76176883
117MP0000751_myopathy0.75611386
118MP0002163_abnormal_gland_morphology0.75186158
119MP0006292_abnormal_olfactory_placode0.74192461
120MP0005389_reproductive_system_phenotype0.73720397
121MP0000266_abnormal_heart_morphology0.73642776
122MP0005076_abnormal_cell_differentiation0.73605870
123MP0005647_abnormal_sex_gland0.72525313
124MP0001529_abnormal_vocalization0.71655671
125MP0002106_abnormal_muscle_physiology0.71545520
126MP0005384_cellular_phenotype0.71498034
127MP0002127_abnormal_cardiovascular_syste0.71389975
128MP0003705_abnormal_hypodermis_morpholog0.71149625
129MP0001764_abnormal_homeostasis0.69827149
130MP0004087_abnormal_muscle_fiber0.69609139
131MP0004133_heterotaxia0.69498807
132MP0001486_abnormal_startle_reflex0.68920490
133MP0002090_abnormal_vision0.67331776
134MP0001963_abnormal_hearing_physiology0.67015396
135MP0001286_abnormal_eye_development0.66698199
136MP0004742_abnormal_vestibular_system0.66465345
137MP0000747_muscle_weakness0.65659866
138MP0002735_abnormal_chemical_nociception0.64359505
139MP0009053_abnormal_anal_canal0.64101475
140MP0009703_decreased_birth_body0.64020576
141MP0005621_abnormal_cell_physiology0.63902367
142MP0006054_spinal_hemorrhage0.63712980
143MP0003656_abnormal_erythrocyte_physiolo0.63110998
144MP0002095_abnormal_skin_pigmentation0.62920662
145MP0000026_abnormal_inner_ear0.62625079
146MP0000647_abnormal_sebaceous_gland0.61925592
147MP0005084_abnormal_gallbladder_morpholo0.60678993
148MP0000371_diluted_coat_color0.60515980
149MP0002429_abnormal_blood_cell0.60498759
150MP0003699_abnormal_female_reproductive0.59832352
151MP0000427_abnormal_hair_cycle0.59613999
152MP0003936_abnormal_reproductive_system0.59153430
153MP0001324_abnormal_eye_pigmentation0.58606319
154MP0002109_abnormal_limb_morphology0.55630778
155MP0002254_reproductive_system_inflammat0.54544777
156MP0002092_abnormal_eye_morphology0.53449093
157MP0002697_abnormal_eye_size0.51257539
158MP0003385_abnormal_body_wall0.51072930
159MP0003935_abnormal_craniofacial_develop0.50183036

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.87067580
2Chronic hepatic failure (HP:0100626)5.75843442
3Tubulointerstitial nephritis (HP:0001970)4.93651139
4Breast hypoplasia (HP:0003187)3.63341531
5Chromsome breakage (HP:0040012)3.62374982
6Aplastic anemia (HP:0001915)3.59838211
7Abnormality of the anterior horn cell (HP:0006802)3.35365405
8Degeneration of anterior horn cells (HP:0002398)3.35365405
9Hepatocellular necrosis (HP:0001404)3.32824849
10Oral leukoplakia (HP:0002745)3.32217017
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.30076171
12Absent/shortened dynein arms (HP:0200106)3.30076171
13Reticulocytopenia (HP:0001896)3.29696576
14Carpal bone hypoplasia (HP:0001498)3.29058341
15Attenuation of retinal blood vessels (HP:0007843)3.26736256
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.26115505
17Abnormality of alanine metabolism (HP:0010916)3.21860694
18Hyperalaninemia (HP:0003348)3.21860694
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.21860694
20Hepatic necrosis (HP:0002605)3.15815628
21Nephronophthisis (HP:0000090)3.10790332
22Cone-rod dystrophy (HP:0000548)3.09723296
23Abnormality of macular pigmentation (HP:0008002)3.04700383
24Bony spicule pigmentary retinopathy (HP:0007737)2.98426393
25Aplasia/Hypoplasia of the earlobes (HP:0009906)2.97398942
26Abnormality of chromosome stability (HP:0003220)2.90767893
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.89188176
28Selective tooth agenesis (HP:0001592)2.82756246
29Volvulus (HP:0002580)2.77961429
30Abnormality of cells of the erythroid lineage (HP:0012130)2.76279778
31Patellar aplasia (HP:0006443)2.74885333
32Abnormality of the renal collecting system (HP:0004742)2.73856835
33Abnormal number of erythroid precursors (HP:0012131)2.71215474
34Microretrognathia (HP:0000308)2.70999144
35Abnormality of the preputium (HP:0100587)2.69980235
36Multiple enchondromatosis (HP:0005701)2.69670190
37Impulsivity (HP:0100710)2.68729112
38Colon cancer (HP:0003003)2.67927779
39Increased serum lactate (HP:0002151)2.64974932
40Short middle phalanx of the 5th finger (HP:0004220)2.61890114
41Entropion (HP:0000621)2.61621734
42Ependymoma (HP:0002888)2.59801985
43Abnormal respiratory motile cilium physiology (HP:0012261)2.58615073
44Male infertility (HP:0003251)2.56786753
45Abnormality of the renal medulla (HP:0100957)2.56001950
46Increased CSF lactate (HP:0002490)2.54314129
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.52536064
48Abnormal ciliary motility (HP:0012262)2.51013933
49Aplasia/Hypoplasia of the patella (HP:0006498)2.50365714
50Tubulointerstitial abnormality (HP:0001969)2.50040130
51Hypoalphalipoproteinemia (HP:0003233)2.49599774
52Mitochondrial inheritance (HP:0001427)2.48451518
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48227183
54Progressive muscle weakness (HP:0003323)2.47703227
55Myelodysplasia (HP:0002863)2.46382712
56Meckel diverticulum (HP:0002245)2.43933753
57Agnosia (HP:0010524)2.40553270
58Medulloblastoma (HP:0002885)2.38382005
59Abnormal mitochondria in muscle tissue (HP:0008316)2.36489733
60Cerebral hypomyelination (HP:0006808)2.34674764
61Absent thumb (HP:0009777)2.34256107
62Renal Fanconi syndrome (HP:0001994)2.34015803
63Rough bone trabeculation (HP:0100670)2.33716736
64Pancreatic cysts (HP:0001737)2.32331163
65Progressive sensorineural hearing impairment (HP:0000408)2.31878285
66Abnormality of the ileum (HP:0001549)2.31694395
67Pancreatic fibrosis (HP:0100732)2.30799715
68Resting tremor (HP:0002322)2.30024705
69Abnormality of the duodenum (HP:0002246)2.29690512
70Acute necrotizing encephalopathy (HP:0006965)2.27898500
71Generalized aminoaciduria (HP:0002909)2.26446979
72Azoospermia (HP:0000027)2.26077711
73Abnormal respiratory motile cilium morphology (HP:0005938)2.25571500
74Abnormal respiratory epithelium morphology (HP:0012253)2.25571500
75Molar tooth sign on MRI (HP:0002419)2.25129523
76Abnormality of midbrain morphology (HP:0002418)2.25129523
77Infertility (HP:0000789)2.22313312
78Rhabdomyosarcoma (HP:0002859)2.19755862
79Exercise intolerance (HP:0003546)2.19582049
80CNS demyelination (HP:0007305)2.19223666
81Increased hepatocellular lipid droplets (HP:0006565)2.18821388
82Microvesicular hepatic steatosis (HP:0001414)2.18121686
83Asymmetric septal hypertrophy (HP:0001670)2.17238851
84Menstrual irregularities (HP:0000858)2.16010398
85Bone marrow hypocellularity (HP:0005528)2.15370943
86Premature ovarian failure (HP:0008209)2.13003685
87Lactic acidosis (HP:0003128)2.12522532
88Pancytopenia (HP:0001876)2.11135691
89Insulin-resistant diabetes mellitus (HP:0000831)2.09531333
90Rhabdomyolysis (HP:0003201)2.09389120
91Lipid accumulation in hepatocytes (HP:0006561)2.09371688
92Renovascular hypertension (HP:0100817)2.08303087
93IgM deficiency (HP:0002850)2.07454239
94Irregular epiphyses (HP:0010582)2.06085665
95Abnormality of pyrimidine metabolism (HP:0004353)2.05685754
96Increased intramyocellular lipid droplets (HP:0012240)2.04945570
97Absent radius (HP:0003974)2.04612112
98Duplicated collecting system (HP:0000081)2.04011313
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03626537
100Horseshoe kidney (HP:0000085)2.03141921
101Sloping forehead (HP:0000340)2.02512194
102Neoplasm of the pancreas (HP:0002894)2.02452975
103Ectopic kidney (HP:0000086)2.01611809
104Subcapsular cataract (HP:0000523)2.00369251
105Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00346875
106Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00346875
107Truncal obesity (HP:0001956)2.00308590
108Portal hypertension (HP:0001409)1.97480704
109Tubular atrophy (HP:0000092)1.96383210
110Abnormality of the carotid arteries (HP:0005344)1.95594851
111True hermaphroditism (HP:0010459)1.95379709
112Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95115375
113Astigmatism (HP:0000483)1.94303759
114Horizontal nystagmus (HP:0000666)1.93798431
115Sclerocornea (HP:0000647)1.92712840
116Squamous cell carcinoma (HP:0002860)1.92361049
117Emotional lability (HP:0000712)1.92351690
118Rectal prolapse (HP:0002035)1.90359846
119Duodenal stenosis (HP:0100867)1.90199792
120Small intestinal stenosis (HP:0012848)1.90199792
121Poikiloderma (HP:0001029)1.89848460
122Hyperglycinemia (HP:0002154)1.89540917
123Megaloblastic anemia (HP:0001889)1.89053264
124Median cleft lip (HP:0000161)1.88921966
125Pendular nystagmus (HP:0012043)1.88812149
126Cerebral edema (HP:0002181)1.87922062
127Increased muscle lipid content (HP:0009058)1.87844486
128Abnormal lung lobation (HP:0002101)1.87736909
129Ventricular tachycardia (HP:0004756)1.87380264
130Neoplasm of the colon (HP:0100273)1.86826659
131Areflexia of lower limbs (HP:0002522)1.86713071
132Neoplasm of the rectum (HP:0100743)1.85119172
133Abnormality of the labia minora (HP:0012880)1.84809666
134Glioma (HP:0009733)1.84557779
135Stage 5 chronic kidney disease (HP:0003774)1.84522111
136Respiratory difficulties (HP:0002880)1.83422140
137Ureteral duplication (HP:0000073)1.81686933
138Hypophosphatemic rickets (HP:0004912)1.81661302
139Abnormal drinking behavior (HP:0030082)1.81617807
140Polydipsia (HP:0001959)1.81617807
141Abnormality of serum amino acid levels (HP:0003112)1.81390007
142Clubbing of toes (HP:0100760)1.81333795
143Absent forearm bone (HP:0003953)1.81217902
144Aplasia involving forearm bones (HP:0009822)1.81217902
145Exertional dyspnea (HP:0002875)1.81200855
146Amaurosis fugax (HP:0100576)1.80987790
147Abnormality of dental color (HP:0011073)1.80483062
148Slender long bone (HP:0003100)1.80229900
149Abnormality of DNA repair (HP:0003254)1.79800370
150Acute encephalopathy (HP:0006846)1.79317837
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.79041966
152Severe visual impairment (HP:0001141)1.78778592
153Bell-shaped thorax (HP:0001591)1.78571730
154Abnormality of sulfur amino acid metabolism (HP:0004339)1.78556320
155Premature graying of hair (HP:0002216)1.78267966
156Abnormal spermatogenesis (HP:0008669)1.78258635
157Stenosis of the external auditory canal (HP:0000402)1.78189169
158Cellular immunodeficiency (HP:0005374)1.77900255
159Abnormality of the hepatic vasculature (HP:0006707)1.77788612
160Intellectual disability, moderate (HP:0002342)1.77132471
161Optic nerve hypoplasia (HP:0000609)1.76518786
162Abnormality of methionine metabolism (HP:0010901)1.74566213
163Hyperkalemia (HP:0002153)1.74253983
164Facial cleft (HP:0002006)1.72562585
165Neoplasm of striated muscle (HP:0009728)1.71637176
166Medial flaring of the eyebrow (HP:0010747)1.71425183
167Sensory axonal neuropathy (HP:0003390)1.71401789
168Nephroblastoma (Wilms tumor) (HP:0002667)1.70027165
169Hypoplasia of the thymus (HP:0000778)1.69616311
170Hypergonadotropic hypogonadism (HP:0000815)1.69148579
171Abnormal rod and cone electroretinograms (HP:0008323)1.67256976
172Postaxial foot polydactyly (HP:0001830)1.66922100
173Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65464444
174Supernumerary spleens (HP:0009799)1.65330690
175Type 2 muscle fiber atrophy (HP:0003554)1.65069529
176Amniotic constriction ring (HP:0009775)1.64987496
177Abnormality of placental membranes (HP:0011409)1.64987496
178Anencephaly (HP:0002323)1.64615659
179Rhinitis (HP:0012384)1.64228183
180Abnormality of aspartate family amino acid metabolism (HP:0010899)1.63201050
181Sandal gap (HP:0001852)1.62602764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.35895694
2BUB13.74188490
3CDC73.21176333
4EIF2AK12.98667820
5INSRR2.84337049
6PLK22.77791032
7PLK42.74831315
8NEK22.69425542
9MAP4K22.62917930
10NEK12.59381236
11EIF2AK32.50857789
12ACVR1B2.40826037
13TRIM282.24565333
14TTK2.23548062
15ZAK2.17295312
16RPS6KA42.14663698
17SRPK12.12907400
18TSSK62.07628440
19NME22.02557686
20MAP2K32.02189883
21DYRK31.88655466
22DDR21.88324283
23PLK11.85596724
24MKNK11.84169114
25BRSK21.77279509
26STK161.77235981
27ATR1.75980490
28PLK31.72216974
29CAMK1G1.71649185
30PDK41.65281318
31PDK31.65281318
32BMPR1B1.61197177
33BCKDK1.57326074
34SCYL21.54416755
35CCNB11.53913484
36MKNK21.51438971
37RPS6KB21.49662110
38MAP3K31.47801526
39FRK1.42540333
40AURKB1.41923899
41PIM21.38050392
42TAF11.37892198
43MAP3K81.37063379
44TAOK21.36245001
45BRAF1.31992308
46PASK1.30027202
47CDK71.29787965
48STK38L1.28838103
49VRK11.25543301
50STK241.24162694
51CDK41.24053577
52VRK21.24034581
53AURKA1.22621224
54TGFBR11.21274655
55CHEK21.13608231
56ERBB31.12250832
57NEK61.11074290
58FLT31.10852922
59MAP3K111.06398934
60TNIK1.03421758
61ARAF1.03085362
62BRSK11.00265417
63STK40.99740342
64RAF10.99271846
65CHEK10.97656734
66MAP3K40.94402228
67STK100.94350130
68ICK0.93556038
69MST1R0.92877243
70AKT30.90038903
71MAP2K70.85123249
72STK390.82667898
73PRKD30.82450447
74LATS10.82321941
75TTN0.82206029
76MST40.80535140
77PDK20.78627289
78CSNK1G10.78278241
79EIF2AK20.77804602
80MAP3K50.77667882
81WNK30.76342619
82ATM0.74681921
83CSNK1G30.70418399
84TESK20.67339359
85PIM10.67132641
86MELK0.64526640
87LRRK20.63259936
88PIK3CG0.62872066
89CSNK1A1L0.62491202
90CDK20.60499093
91CAMK1D0.59995215
92CSNK1G20.59791230
93EPHA20.59583385
94BCR0.59057297
95TIE10.58631173
96CSNK2A20.58144507
97PKN20.58097652
98TAOK10.58065618
99STK380.57741508
100ERBB40.56201664
101CSNK2A10.55859104
102KIT0.55212700
103BRD40.54659840
104NUAK10.53071154
105MUSK0.52477769
106WNK10.51454984
107CDK10.49955116
108ALK0.47298949
109TLK10.47016309
110PAK40.46171605
111NME10.46068896
112MAP3K90.45668006
113MET0.44085970
114STK30.43436588
115PINK10.42378063
116CDK30.41340272
117PBK0.40373128
118ILK0.39939325
119TYRO30.39803450
120RPS6KA50.39628826
121PTK2B0.39135857
122MYLK0.37964812
123RPS6KC10.37295572
124RPS6KL10.37295572
125WNK40.37266696
126CDK60.37235022
127PAK10.36804383
128DYRK20.36438336
129ZAP700.35759385
130TESK10.33849516
131ADRBK20.33110310
132PRKCG0.32206918
133CDK90.32154521
134MAP4K10.31854073
135EEF2K0.31313964
136KDR0.31257061
137PRKCI0.31234500
138PNCK0.31231884
139AKT20.31085893
140CDK120.30788603
141MAPK110.29526268
142RPS6KA60.28509287
143NEK90.27900236
144MTOR0.26770022
145CSNK1A10.26330311
146GSK3B0.24240079
147PRKDC0.23985173
148CSNK1E0.23756219
149PRKCE0.23474855
150OXSR10.19892148

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.91288672
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.32010080
3Mismatch repair_Homo sapiens_hsa034304.17802911
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.93224105
5Proteasome_Homo sapiens_hsa030503.58787817
6RNA polymerase_Homo sapiens_hsa030203.39203262
7RNA transport_Homo sapiens_hsa030133.11743051
8Fatty acid biosynthesis_Homo sapiens_hsa000613.06168380
9Spliceosome_Homo sapiens_hsa030402.83090451
10Ribosome_Homo sapiens_hsa030102.79318042
11Nucleotide excision repair_Homo sapiens_hsa034202.76482557
12Homologous recombination_Homo sapiens_hsa034402.74069934
13One carbon pool by folate_Homo sapiens_hsa006702.64763204
14Pyrimidine metabolism_Homo sapiens_hsa002402.63086731
15Base excision repair_Homo sapiens_hsa034102.55155808
16Cell cycle_Homo sapiens_hsa041102.48749501
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38420882
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19466164
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09467341
20Fanconi anemia pathway_Homo sapiens_hsa034602.03644182
21RNA degradation_Homo sapiens_hsa030181.80685216
22Basal transcription factors_Homo sapiens_hsa030221.74653232
23Butanoate metabolism_Homo sapiens_hsa006501.65381245
24Non-homologous end-joining_Homo sapiens_hsa034501.63381765
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60654462
26Fatty acid metabolism_Homo sapiens_hsa012121.54328234
27Olfactory transduction_Homo sapiens_hsa047401.44855167
28mRNA surveillance pathway_Homo sapiens_hsa030151.44314458
29Purine metabolism_Homo sapiens_hsa002301.42281696
30p53 signaling pathway_Homo sapiens_hsa041151.41043476
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.37660663
32Biosynthesis of amino acids_Homo sapiens_hsa012301.35244413
33Vitamin B6 metabolism_Homo sapiens_hsa007501.32527294
34Carbon metabolism_Homo sapiens_hsa012001.32056902
35Pentose phosphate pathway_Homo sapiens_hsa000301.28617725
36Steroid biosynthesis_Homo sapiens_hsa001001.20252858
37Epstein-Barr virus infection_Homo sapiens_hsa051691.13621679
38Glutathione metabolism_Homo sapiens_hsa004801.06920546
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.06086240
40Selenocompound metabolism_Homo sapiens_hsa004501.01839869
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94781894
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93273947
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90612220
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.90118532
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89469380
46Parkinsons disease_Homo sapiens_hsa050120.88829786
47Huntingtons disease_Homo sapiens_hsa050160.87696306
48Fatty acid elongation_Homo sapiens_hsa000620.85866703
49Antigen processing and presentation_Homo sapiens_hsa046120.85153989
50Protein export_Homo sapiens_hsa030600.84674039
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80942538
52Oocyte meiosis_Homo sapiens_hsa041140.79370430
53Folate biosynthesis_Homo sapiens_hsa007900.78573163
54Phototransduction_Homo sapiens_hsa047440.78532498
55Propanoate metabolism_Homo sapiens_hsa006400.77710462
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74355029
57Systemic lupus erythematosus_Homo sapiens_hsa053220.72564013
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71893508
59Thyroid cancer_Homo sapiens_hsa052160.71599897
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70420725
61Oxidative phosphorylation_Homo sapiens_hsa001900.67414803
62Viral carcinogenesis_Homo sapiens_hsa052030.67352674
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66720687
64Herpes simplex infection_Homo sapiens_hsa051680.65010374
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60348401
66Pyruvate metabolism_Homo sapiens_hsa006200.55802863
67Galactose metabolism_Homo sapiens_hsa000520.54429177
68Fructose and mannose metabolism_Homo sapiens_hsa000510.52397295
69Tryptophan metabolism_Homo sapiens_hsa003800.52345324
70Taste transduction_Homo sapiens_hsa047420.51341490
71Hedgehog signaling pathway_Homo sapiens_hsa043400.50696281
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50200269
73Legionellosis_Homo sapiens_hsa051340.48528389
74TGF-beta signaling pathway_Homo sapiens_hsa043500.47622596
75HTLV-I infection_Homo sapiens_hsa051660.45565502
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44933648
77Sulfur relay system_Homo sapiens_hsa041220.44391944
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44066329
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.42428591
80Metabolic pathways_Homo sapiens_hsa011000.40908960
81Fatty acid degradation_Homo sapiens_hsa000710.38200871
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37965130
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36346357
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35337719
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35304974
86N-Glycan biosynthesis_Homo sapiens_hsa005100.34059124
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33342830
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32249683
89Retinol metabolism_Homo sapiens_hsa008300.32108457
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.31234594
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31006851
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30629130
93HIF-1 signaling pathway_Homo sapiens_hsa040660.29585924
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29342911
95Hippo signaling pathway_Homo sapiens_hsa043900.28675048
96Sphingolipid metabolism_Homo sapiens_hsa006000.26637066
97Arginine and proline metabolism_Homo sapiens_hsa003300.26374632
98Caffeine metabolism_Homo sapiens_hsa002320.25180505
99Cardiac muscle contraction_Homo sapiens_hsa042600.24975405
100Chemical carcinogenesis_Homo sapiens_hsa052040.24575251
101Viral myocarditis_Homo sapiens_hsa054160.23714762
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23423993
103Nitrogen metabolism_Homo sapiens_hsa009100.23315245
104Small cell lung cancer_Homo sapiens_hsa052220.23235311
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.22208831
106MicroRNAs in cancer_Homo sapiens_hsa052060.21281565
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20007085
108Sulfur metabolism_Homo sapiens_hsa009200.20000465
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19693387
110Alzheimers disease_Homo sapiens_hsa050100.19671489
111Glycerolipid metabolism_Homo sapiens_hsa005610.16629355
112Lysine degradation_Homo sapiens_hsa003100.16057686
113Apoptosis_Homo sapiens_hsa042100.15796978
114Tyrosine metabolism_Homo sapiens_hsa003500.15409347
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15356019
116Glucagon signaling pathway_Homo sapiens_hsa049220.14604317
117mTOR signaling pathway_Homo sapiens_hsa041500.14323431
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13080224
119PPAR signaling pathway_Homo sapiens_hsa033200.13038006
120Wnt signaling pathway_Homo sapiens_hsa043100.12511215
121Colorectal cancer_Homo sapiens_hsa052100.12124175
122Primary immunodeficiency_Homo sapiens_hsa053400.11164967
123Dorso-ventral axis formation_Homo sapiens_hsa043200.10960337
124Basal cell carcinoma_Homo sapiens_hsa052170.09918587
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.09837463
126beta-Alanine metabolism_Homo sapiens_hsa004100.09676943
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09467802
128Phenylalanine metabolism_Homo sapiens_hsa003600.09202076
129Regulation of autophagy_Homo sapiens_hsa041400.07166188
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.05492621
131Starch and sucrose metabolism_Homo sapiens_hsa005000.05483186
132Hepatitis B_Homo sapiens_hsa051610.05251905
133Acute myeloid leukemia_Homo sapiens_hsa052210.04509131
134Peroxisome_Homo sapiens_hsa041460.03320628

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