TRMT61A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.51790580
2ribosome assembly (GO:0042255)4.96027947
3ribosome biogenesis (GO:0042254)4.78168698
4nucleobase biosynthetic process (GO:0046112)4.77246225
5DNA deamination (GO:0045006)4.76462896
6formation of translation preinitiation complex (GO:0001731)4.65870250
7maturation of SSU-rRNA (GO:0030490)4.65566416
8DNA unwinding involved in DNA replication (GO:0006268)4.48284240
9IMP biosynthetic process (GO:0006188)4.43210526
10negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.38091829
11regulation of mammary gland epithelial cell proliferation (GO:0033599)4.33890912
12DNA strand elongation involved in DNA replication (GO:0006271)4.28437316
13DNA replication initiation (GO:0006270)4.20739247
14protein localization to kinetochore (GO:0034501)4.19433168
15ribonucleoprotein complex biogenesis (GO:0022613)4.17492991
16purine nucleobase biosynthetic process (GO:0009113)4.17213468
17peptidyl-arginine omega-N-methylation (GO:0035247)4.15631142
18ribosomal large subunit biogenesis (GO:0042273)4.15553379
19mitotic nuclear envelope disassembly (GO:0007077)4.11053325
20DNA strand elongation (GO:0022616)4.06363768
21telomere maintenance via semi-conservative replication (GO:0032201)3.97797597
22regulation of translational fidelity (GO:0006450)3.92482010
23proline biosynthetic process (GO:0006561)3.91290847
24rRNA processing (GO:0006364)3.88655023
25folic acid metabolic process (GO:0046655)3.87477721
26nuclear envelope disassembly (GO:0051081)3.84384336
27membrane disassembly (GO:0030397)3.84384336
28spliceosomal snRNP assembly (GO:0000387)3.83401843
29pseudouridine synthesis (GO:0001522)3.82400262
30viral transcription (GO:0019083)3.77726930
31translational initiation (GO:0006413)3.74882371
32rRNA metabolic process (GO:0016072)3.74355279
33translational termination (GO:0006415)3.74011737
34IMP metabolic process (GO:0046040)3.73986524
35negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.73129791
36rRNA modification (GO:0000154)3.71783210
37DNA replication checkpoint (GO:0000076)3.71539801
38nuclear pore organization (GO:0006999)3.70205601
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.70057031
40mitotic metaphase plate congression (GO:0007080)3.68262793
41regulation of translational termination (GO:0006449)3.63760661
42ribosomal small subunit assembly (GO:0000028)3.62228788
43histone arginine methylation (GO:0034969)3.56660332
44peptidyl-arginine N-methylation (GO:0035246)3.53663308
45peptidyl-arginine methylation (GO:0018216)3.53663308
46COPI coating of Golgi vesicle (GO:0048205)3.48796032
47Golgi transport vesicle coating (GO:0048200)3.48796032
48translational elongation (GO:0006414)3.48057701
49nuclear pore complex assembly (GO:0051292)3.47690969
50GDP-mannose metabolic process (GO:0019673)3.46417268
51pteridine-containing compound biosynthetic process (GO:0042559)3.46208226
52apoptotic process involved in morphogenesis (GO:0060561)3.43212476
53nuclear envelope reassembly (GO:0031468)3.42769150
54mitotic nuclear envelope reassembly (GO:0007084)3.42769150
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.42458441
56protein localization to chromosome, centromeric region (GO:0071459)3.40550886
57negative regulation of cell size (GO:0045792)3.40011021
58pentose-phosphate shunt (GO:0006098)3.39535365
59telomere maintenance via recombination (GO:0000722)3.37613353
60negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.37272176
61DNA replication-dependent nucleosome assembly (GO:0006335)3.36615679
62DNA replication-dependent nucleosome organization (GO:0034723)3.36615679
63protein maturation by protein folding (GO:0022417)3.35956821
64negative regulation of RNA splicing (GO:0033119)3.35302336
65negative regulation of erythrocyte differentiation (GO:0045647)3.23834270
66protein localization to endosome (GO:0036010)3.23521419
67negative regulation of mRNA processing (GO:0050686)3.23085833
68heterochromatin organization (GO:0070828)3.21542932
69DNA duplex unwinding (GO:0032508)3.16873777
70NIK/NF-kappaB signaling (GO:0038061)3.16853795
71mitotic chromosome condensation (GO:0007076)3.16361404
72cellular protein complex localization (GO:0034629)3.15885150
73telomere maintenance via telomere lengthening (GO:0010833)3.15452073
74RNA splicing, via transesterification reactions (GO:0000375)3.15201785
75DNA geometric change (GO:0032392)3.14307925
76pre-miRNA processing (GO:0031054)3.13590503
77mRNA splicing, via spliceosome (GO:0000398)3.13561380
78RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.13561380
79mitotic recombination (GO:0006312)3.13005020
80rRNA methylation (GO:0031167)3.06775004
81spliceosomal tri-snRNP complex assembly (GO:0000244)3.06138769
82regulation of spindle organization (GO:0090224)3.06003577
83ribosomal small subunit biogenesis (GO:0042274)3.02765083
84nuclear envelope organization (GO:0006998)3.02518072
85SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.01976828
86activation of MAPKKK activity (GO:0000185)3.01226158
87proteasome assembly (GO:0043248)3.00830805
88pinocytosis (GO:0006907)3.00572749
89mitochondrial fusion (GO:0008053)2.99461988
90nucleobase-containing small molecule interconversion (GO:0015949)2.99259163
91glucose catabolic process (GO:0006007)2.99250726
92negative regulation of mRNA metabolic process (GO:1903312)2.98909397
93rRNA transcription (GO:0009303)2.97417778
94nucleotide-excision repair, DNA gap filling (GO:0006297)2.97156709
95termination of RNA polymerase II transcription (GO:0006369)2.96529191
96pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.96443288
97pentose metabolic process (GO:0019321)2.95878196
98metaphase plate congression (GO:0051310)2.95416575
99transcription from mitochondrial promoter (GO:0006390)2.93652601
100cellular protein complex disassembly (GO:0043624)2.93585052
101viral mRNA export from host cell nucleus (GO:0046784)2.91530408
102mannose metabolic process (GO:0006013)2.91428356
103protein targeting to ER (GO:0045047)2.90212166
104mitochondrial DNA metabolic process (GO:0032042)2.90072423
105spliceosomal complex assembly (GO:0000245)2.89979392
106* ncRNA processing (GO:0034470)2.89803457
107modulation by symbiont of host cellular process (GO:0044068)2.89509584
108cotranslational protein targeting to membrane (GO:0006613)2.87222956
109mitotic G1 DNA damage checkpoint (GO:0031571)2.86519821
110UV protection (GO:0009650)2.86296493
111protein retention in ER lumen (GO:0006621)2.85738099
112viral life cycle (GO:0019058)2.85599200
113activation of Rac GTPase activity (GO:0032863)2.85389099
114nuclear-transcribed mRNA catabolic process (GO:0000956)2.84906144
115cellular component biogenesis (GO:0044085)2.84124139
116pore complex assembly (GO:0046931)2.83892231
117maturation of 5.8S rRNA (GO:0000460)2.82951211
118endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.82773530
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82368923
120protein complex localization (GO:0031503)2.81769483
121ribonucleoprotein complex assembly (GO:0022618)2.81760198
122mitochondrial RNA metabolic process (GO:0000959)2.81437900
123tetrahydrofolate metabolic process (GO:0046653)2.80120980
124NADPH regeneration (GO:0006740)2.79831662
125focal adhesion assembly (GO:0048041)2.79579474
126cell-substrate adherens junction assembly (GO:0007045)2.79579474
127RNA catabolic process (GO:0006401)2.79144661
128T cell apoptotic process (GO:0070231)2.78952147
129negative regulation of viral release from host cell (GO:1902187)2.78459313
130regulation of translational elongation (GO:0006448)2.78412564
131adherens junction assembly (GO:0034333)2.77446516
132tRNA aminoacylation for protein translation (GO:0006418)2.77316030
133protein complex disassembly (GO:0043241)2.77162471
134* ncRNA metabolic process (GO:0034660)2.76329265
135regulation of chromatin binding (GO:0035561)2.76172586
136pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.76091682
137positive regulation of Cdc42 GTPase activity (GO:0043089)2.75947787
138positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.75272194
139maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73856550
140retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.72112661
1413-UTR-mediated mRNA stabilization (GO:0070935)2.71851900
142deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.71468164
143pyrimidine nucleoside salvage (GO:0043097)2.70289559
144pyrimidine-containing compound salvage (GO:0008655)2.70289559
145intracellular estrogen receptor signaling pathway (GO:0030520)2.64963816
146modulation by virus of host process (GO:0019054)2.62652581
147positive regulation of keratinocyte differentiation (GO:0045618)2.61860998
148regulation of apoptotic process involved in morphogenesis (GO:1902337)2.60971737
149nucleotide salvage (GO:0043173)2.58564536
150regulation of early endosome to late endosome transport (GO:2000641)2.54779061
151protein insertion into membrane (GO:0051205)2.54695242
152cellular response to virus (GO:0098586)2.52993445
153stress fiber assembly (GO:0043149)2.52492675
154regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.52385294
155low-density lipoprotein particle clearance (GO:0034383)2.50735476
156maternal placenta development (GO:0001893)2.48565557
157regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46869722
158response to peptidoglycan (GO:0032494)2.45931047
159* tRNA methylation (GO:0030488)2.42679830
160chaperone mediated protein folding requiring cofactor (GO:0051085)2.42445746
161pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.42251942
162proline metabolic process (GO:0006560)2.42194800
163regulation of glucose import in response to insulin stimulus (GO:2001273)2.42078269
164epithelial cell differentiation involved in prostate gland development (GO:0060742)2.41760060
165regulation of vitamin D biosynthetic process (GO:0060556)2.39245594
166pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.37436963
167leukocyte apoptotic process (GO:0071887)2.36746654
168positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.35821804
169lymphocyte apoptotic process (GO:0070227)2.34994113
170regulation of superoxide anion generation (GO:0032928)2.33182861
171barbed-end actin filament capping (GO:0051016)2.30696830
172negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.29928111
173negative regulation of DNA-templated transcription, elongation (GO:0032785)2.29626729
174embryo implantation (GO:0007566)2.27715287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.51753556
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.72302328
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.09748941
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.31884809
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.27986061
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.02298983
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93221610
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92486336
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90635073
10MYC_22102868_ChIP-Seq_BL_Human2.77800126
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.69453157
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59178347
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53763191
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.44194351
15XRN2_22483619_ChIP-Seq_HELA_Human2.41435901
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.33706540
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33027749
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.29630180
19LXR_22292898_ChIP-Seq_THP-1_Human2.27655683
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18493953
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18275777
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.17342595
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15344502
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06471048
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04207730
26VDR_23849224_ChIP-Seq_CD4+_Human2.01674178
27GABP_19822575_ChIP-Seq_HepG2_Human1.94656159
28* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94464414
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92663273
30RACK7_27058665_Chip-Seq_MCF-7_Human1.92019775
31DCP1A_22483619_ChIP-Seq_HELA_Human1.89434998
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88597768
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.86967272
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.86380954
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85865859
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84682556
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80919807
38TTF2_22483619_ChIP-Seq_HELA_Human1.80541760
39FOXP3_21729870_ChIP-Seq_TREG_Human1.80257710
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79194345
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75880393
42CIITA_25753668_ChIP-Seq_RAJI_Human1.72666800
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71713653
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71421086
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70556945
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.69994839
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69353425
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68527714
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65662250
50VDR_21846776_ChIP-Seq_THP-1_Human1.65220227
51KDM5A_27292631_Chip-Seq_BREAST_Human1.62968479
52AR_21909140_ChIP-Seq_LNCAP_Human1.60860719
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57331386
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57221663
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.54021141
56P68_20966046_ChIP-Seq_HELA_Human1.52718574
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.49953491
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49667924
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48996156
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48660603
61KDM2B_26808549_Chip-Seq_DND41_Human1.47531764
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43965235
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42278052
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40509049
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39503389
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38701530
67* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37657777
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35879252
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.35114173
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.33128101
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32062635
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31815071
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30020363
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29709660
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28878183
76* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27737985
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27082923
78VDR_24763502_ChIP-Seq_THP-1_Human1.26004956
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25193764
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24148513
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24006867
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19095005
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18504295
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18082542
85SMC4_20622854_ChIP-Seq_HELA_Human1.17613017
86MAF_26560356_Chip-Seq_TH1_Human1.17458599
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.17235014
88TFEB_21752829_ChIP-Seq_HELA_Human1.16337030
89BCOR_27268052_Chip-Seq_Bcells_Human1.16055301
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15559365
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14680052
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.14080947
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14045626
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13932424
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12649809
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11636108
97* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11406707
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11117262
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10843517
100KDM2B_26808549_Chip-Seq_K562_Human1.10830246
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10664673
102ESR2_21235772_ChIP-Seq_MCF-7_Human1.10663783
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10172716
104* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10167387
105CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08846169
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08819405
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08283450
108CTCF_26484167_Chip-Seq_Bcells_Mouse1.08241013
109ZNF263_19887448_ChIP-Seq_K562_Human1.06607496
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06429964
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05684536
112* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05563666
113ELK1_19687146_ChIP-ChIP_HELA_Human1.04750695
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04208676
115NCOR1_26117541_ChIP-Seq_K562_Human1.03857131
116PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03544942
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03303965
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03128372
119BCL6_27268052_Chip-Seq_Bcells_Human1.03081828
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02814874
121CREB1_26743006_Chip-Seq_LNCaP_Human1.02514080
122* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01982957
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00042364
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99595208
125HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98513734
126SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97511462
127* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96314261
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93798255
129UTX_26944678_Chip-Seq_JUKART_Human0.92518506
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.92468652
131SRF_21415370_ChIP-Seq_HL-1_Mouse0.92120870
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90940156
133FOXP1_21924763_ChIP-Seq_HESCs_Human0.89851339
134MAF_26560356_Chip-Seq_TH2_Human0.89584267
135TCF7_22412390_ChIP-Seq_EML_Mouse0.89373906
136TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88873223
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88535591
138ATF3_27146783_Chip-Seq_COLON_Human0.88509157
139NANOG_21062744_ChIP-ChIP_HESCs_Human0.88097053
140SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87871613
141SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87844421
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87428851
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85451617
144SPI1_23547873_ChIP-Seq_NB4_Human0.85292316
145KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85214771
146ELK1_22589737_ChIP-Seq_MCF10A_Human0.85183396
147MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84510882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.56771683
2MP0004957_abnormal_blastocyst_morpholog4.80722072
3MP0003111_abnormal_nucleus_morphology4.41389755
4MP0005451_abnormal_body_composition4.02952215
5MP0010094_abnormal_chromosome_stability3.92225872
6MP0003077_abnormal_cell_cycle3.75292807
7MP0005058_abnormal_lysosome_morphology3.61800989
8MP0008057_abnormal_DNA_replication3.60373960
9MP0002396_abnormal_hematopoietic_system2.84401382
10MP0008058_abnormal_DNA_repair2.69338527
11MP0001730_embryonic_growth_arrest2.64242345
12MP0002877_abnormal_melanocyte_morpholog2.63106512
13MP0010352_gastrointestinal_tract_polyps2.57465926
14MP0004185_abnormal_adipocyte_glucose2.57164282
15MP0000350_abnormal_cell_proliferation2.51242061
16MP0008260_abnormal_autophagy2.46838239
17MP0008007_abnormal_cellular_replicative2.31306095
18MP0008932_abnormal_embryonic_tissue2.23958505
19MP0003453_abnormal_keratinocyte_physiol2.23325257
20MP0003123_paternal_imprinting2.21866521
21MP0010307_abnormal_tumor_latency2.18617774
22MP0010030_abnormal_orbit_morphology2.07924837
23MP0003191_abnormal_cellular_cholesterol2.03224739
24MP0005076_abnormal_cell_differentiation1.99613107
25MP0001672_abnormal_embryogenesis/_devel1.94987581
26MP0005380_embryogenesis_phenotype1.94987581
27MP0006292_abnormal_olfactory_placode1.94297838
28MP0002796_impaired_skin_barrier1.93253319
29MP0000490_abnormal_crypts_of1.85903121
30MP0001697_abnormal_embryo_size1.85829399
31MP0002080_prenatal_lethality1.82191269
32MP0005501_abnormal_skin_physiology1.81371628
33MP0009333_abnormal_splenocyte_physiolog1.80707899
34MP0003984_embryonic_growth_retardation1.78757039
35MP0002088_abnormal_embryonic_growth/wei1.74579180
36MP0002254_reproductive_system_inflammat1.74382649
37MP0002085_abnormal_embryonic_tissue1.71665685
38MP0004510_myositis1.69768161
39MP0002086_abnormal_extraembryonic_tissu1.65984954
40MP0001293_anophthalmia1.63973248
41MP0003786_premature_aging1.63547340
42MP0003763_abnormal_thymus_physiology1.63481487
43MP0004947_skin_inflammation1.62642790
44MP0000313_abnormal_cell_death1.61284474
45MP0004197_abnormal_fetal_growth/weight/1.60414641
46MP0002084_abnormal_developmental_patter1.59562138
47MP0010234_abnormal_vibrissa_follicle1.58485795
48MP0005666_abnormal_adipose_tissue1.55102933
49MP0002019_abnormal_tumor_incidence1.53567854
50MP0001545_abnormal_hematopoietic_system1.53483664
51MP0005397_hematopoietic_system_phenotyp1.53483664
52MP0004808_abnormal_hematopoietic_stem1.52997591
53MP0003806_abnormal_nucleotide_metabolis1.47895807
54MP0003890_abnormal_embryonic-extraembry1.47792529
55MP0004858_abnormal_nervous_system1.45910312
56MP0000703_abnormal_thymus_morphology1.44896289
57MP0009672_abnormal_birth_weight1.36557480
58MP0002398_abnormal_bone_marrow1.32563461
59MP0002249_abnormal_larynx_morphology1.32284031
60MP0005375_adipose_tissue_phenotype1.30237662
61MP0005623_abnormal_meninges_morphology1.24761969
62MP0003119_abnormal_digestive_system1.24020445
63MP0000858_altered_metastatic_potential1.23315011
64MP0003172_abnormal_lysosome_physiology1.21511465
65MP0000003_abnormal_adipose_tissue1.20953451
66MP0008877_abnormal_DNA_methylation1.19651637
67MP0002722_abnormal_immune_system1.19116074
68MP0003075_altered_response_to1.18830539
69MP0002060_abnormal_skin_morphology1.15571032
70MP0001873_stomach_inflammation1.15222399
71MP0003705_abnormal_hypodermis_morpholog1.15173693
72MP0001216_abnormal_epidermal_layer1.15148690
73MP0009053_abnormal_anal_canal1.11875612
74MP0000689_abnormal_spleen_morphology1.09976134
75MP0003567_abnormal_fetal_cardiomyocyte1.09882500
76MP0003303_peritoneal_inflammation1.08179737
77MP0008438_abnormal_cutaneous_collagen1.05446514
78MP0003718_maternal_effect1.03867330
79MP0003329_amyloid_beta_deposits1.03232305
80MP0009379_abnormal_foot_pigmentation1.02308182
81MP0003091_abnormal_cell_migration1.00438445
82MP0002132_abnormal_respiratory_system1.00365347
83MP0001346_abnormal_lacrimal_gland0.99400610
84MP0000358_abnormal_cell_content/0.99027129
85MP0002089_abnormal_postnatal_growth/wei0.97606897
86MP0002429_abnormal_blood_cell0.96807558
87MP0000428_abnormal_craniofacial_morphol0.96804049
88MP0000678_abnormal_parathyroid_gland0.95864551
89MP0008770_decreased_survivor_rate0.94165578
90MP0000747_muscle_weakness0.92619831
91MP0000681_abnormal_thyroid_gland0.92234358
92MP0000537_abnormal_urethra_morphology0.91973829
93MP0009931_abnormal_skin_appearance0.91207961
94MP0003566_abnormal_cell_adhesion0.89813629
95MP0009703_decreased_birth_body0.89162901
96MP0005621_abnormal_cell_physiology0.88064193
97MP0000604_amyloidosis0.87788494
98MP0009278_abnormal_bone_marrow0.87275259
99MP0005384_cellular_phenotype0.86908955
100MP0002148_abnormal_hypersensitivity_rea0.85928053
101MP0002098_abnormal_vibrissa_morphology0.85622875
102MP0002210_abnormal_sex_determination0.85462697
103MP0000343_altered_response_to0.84578958
104MP0000716_abnormal_immune_system0.84291990
105MP0003300_gastrointestinal_ulcer0.82718143
106MP0002092_abnormal_eye_morphology0.80235864
107MP0000751_myopathy0.80051503
108MP0001145_abnormal_male_reproductive0.80022116
109MP0002075_abnormal_coat/hair_pigmentati0.78807229
110MP0002653_abnormal_ependyma_morphology0.78216263
111MP0001881_abnormal_mammary_gland0.77615297
112MP0001243_abnormal_dermal_layer0.77603962
113MP0001533_abnormal_skeleton_physiology0.77475596
114MP0001727_abnormal_embryo_implantation0.76826228
115MP0000750_abnormal_muscle_regeneration0.76203826
116MP0002998_abnormal_bone_remodeling0.76009173
117MP0003279_aneurysm0.75592665
118MP0005000_abnormal_immune_tolerance0.75564756
119MP0003878_abnormal_ear_physiology0.75262805
120MP0005377_hearing/vestibular/ear_phenot0.75262805
121MP0005670_abnormal_white_adipose0.74525614
122MP0004233_abnormal_muscle_weight0.74155409
123MP0000759_abnormal_skeletal_muscle0.73482317
124MP0002111_abnormal_tail_morphology0.73055289
125MP0009840_abnormal_foam_cell0.72723482
126MP0005174_abnormal_tail_pigmentation0.72260122
127MP0003436_decreased_susceptibility_to0.70957847
128MP0005310_abnormal_salivary_gland0.70853531
129MP0002405_respiratory_system_inflammati0.70643933
130MP0000477_abnormal_intestine_morphology0.70413925
131MP0002970_abnormal_white_adipose0.69791318
132MP0001919_abnormal_reproductive_system0.69621661
133MP0001800_abnormal_humoral_immune0.68659036
134MP0005023_abnormal_wound_healing0.68174004
135MP0003121_genomic_imprinting0.67236131
136MP0000733_abnormal_muscle_development0.64356432
137MP0000371_diluted_coat_color0.63952641
138MP0000685_abnormal_immune_system0.63799303
139MP0005257_abnormal_intraocular_pressure0.63695075
140MP0001853_heart_inflammation0.63018396
141MP0005389_reproductive_system_phenotype0.61532024
142MP0003448_altered_tumor_morphology0.61024382
143MP0001849_ear_inflammation0.60768893
144MP0000653_abnormal_sex_gland0.58865250
145MP0004133_heterotaxia0.58421798
146MP0000627_abnormal_mammary_gland0.57802306
147MP0002160_abnormal_reproductive_system0.57436329
148MP0008789_abnormal_olfactory_epithelium0.57096080
149MP0001348_abnormal_lacrimal_gland0.56842567

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.44093391
2Abnormality of cells of the erythroid lineage (HP:0012130)4.00956231
3Abnormal number of erythroid precursors (HP:0012131)3.96242216
4Reticulocytopenia (HP:0001896)3.96178221
5Hyperacusis (HP:0010780)3.87173050
6Achilles tendon contracture (HP:0001771)3.68620788
7Breast hypoplasia (HP:0003187)3.68260947
8Selective tooth agenesis (HP:0001592)3.65777636
9Unilateral renal agenesis (HP:0000122)3.42132080
10Ependymoma (HP:0002888)3.38467319
11Rough bone trabeculation (HP:0100670)3.30926971
12Degeneration of anterior horn cells (HP:0002398)3.28942554
13Abnormality of the anterior horn cell (HP:0006802)3.28942554
14Oral leukoplakia (HP:0002745)3.22747410
15Cerebral hypomyelination (HP:0006808)3.22719273
16Patellar aplasia (HP:0006443)3.21384165
17Abnormality of the Achilles tendon (HP:0005109)3.19534426
18Ragged-red muscle fibers (HP:0003200)3.10825134
19Microretrognathia (HP:0000308)3.04065869
20Absent thumb (HP:0009777)3.02456724
21Aplasia/Hypoplasia of the patella (HP:0006498)3.01908209
22Trismus (HP:0000211)2.99138999
23Abnormal number of incisors (HP:0011064)2.95537181
24Progressive muscle weakness (HP:0003323)2.93945229
25Distal lower limb amyotrophy (HP:0008944)2.91581144
26Vertebral compression fractures (HP:0002953)2.90445212
27Colon cancer (HP:0003003)2.90199855
28Premature graying of hair (HP:0002216)2.89230317
29Pallor (HP:0000980)2.85760105
30Ulnar bowing (HP:0003031)2.72465452
31Basal cell carcinoma (HP:0002671)2.66637360
32Macrocytic anemia (HP:0001972)2.55458115
33Broad face (HP:0000283)2.55409644
34Abnormality of glycolipid metabolism (HP:0010969)2.51124016
35Abnormality of liposaccharide metabolism (HP:0010968)2.51124016
36Abnormality of glycosphingolipid metabolism (HP:0004343)2.51124016
37Premature rupture of membranes (HP:0001788)2.50647552
38Pelvic girdle muscle weakness (HP:0003749)2.49707536
39Increased cerebral lipofuscin (HP:0011813)2.49135886
40Rhabdomyosarcoma (HP:0002859)2.48491350
41Broad distal phalanx of finger (HP:0009836)2.47726768
42Insomnia (HP:0100785)2.46144048
43Short nail (HP:0001799)2.45487551
44Difficulty climbing stairs (HP:0003551)2.43628006
45Premature ovarian failure (HP:0008209)2.42945623
46Distal upper limb amyotrophy (HP:0007149)2.42676615
47Upper limb amyotrophy (HP:0009129)2.42676615
48Absent radius (HP:0003974)2.42412917
49Increased serum ferritin (HP:0003281)2.42345641
50Generalized amyotrophy (HP:0003700)2.42107900
51Chromsome breakage (HP:0040012)2.41204241
52Distal lower limb muscle weakness (HP:0009053)2.41168088
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38523813
54Impulsivity (HP:0100710)2.37220008
55Axonal loss (HP:0003447)2.36423816
56Prominent nose (HP:0000448)2.35839947
57Carpal bone hypoplasia (HP:0001498)2.33161439
58Increased connective tissue (HP:0009025)2.31799995
59Testicular atrophy (HP:0000029)2.30015087
60Abnormality of the preputium (HP:0100587)2.29876342
61Facial hemangioma (HP:0000329)2.29689828
62Myelodysplasia (HP:0002863)2.29194628
63Aplastic anemia (HP:0001915)2.29083667
64Meckel diverticulum (HP:0002245)2.28088873
65Medulloblastoma (HP:0002885)2.27627921
66Abnormality of the ileum (HP:0001549)2.27616405
67Absent forearm bone (HP:0003953)2.27261024
68Aplasia involving forearm bones (HP:0009822)2.27261024
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26431282
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.25501268
71Cheilitis (HP:0100825)2.25387032
72Abnormal trabecular bone morphology (HP:0100671)2.25297843
73Multiple enchondromatosis (HP:0005701)2.24974585
74Agnosia (HP:0010524)2.24385957
75Genu recurvatum (HP:0002816)2.24246993
76Horseshoe kidney (HP:0000085)2.23023993
77Thin bony cortex (HP:0002753)2.21402452
78Atrophy/Degeneration involving motor neurons (HP:0007373)2.18442324
79Spinal muscular atrophy (HP:0007269)2.18304816
80Aplasia/Hypoplasia of the uvula (HP:0010293)2.18196575
81Abnormality of the umbilical cord (HP:0010881)2.16499498
82Hyperparathyroidism (HP:0000843)2.16428734
83Proximal placement of thumb (HP:0009623)2.16026762
84Abnormality of the astrocytes (HP:0100707)2.13741170
85Astrocytoma (HP:0009592)2.13741170
86Stridor (HP:0010307)2.13600717
87Abnormality of the labia minora (HP:0012880)2.13010857
88Neoplasm of the pancreas (HP:0002894)2.11962262
89Abnormality of the distal phalanges of the toes (HP:0010182)2.11468227
90Long palpebral fissure (HP:0000637)2.11438796
91Amaurosis fugax (HP:0100576)2.08351400
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08055797
93Abnormality of chromosome stability (HP:0003220)2.07799098
94Tracheoesophageal fistula (HP:0002575)2.07102856
95Cellular immunodeficiency (HP:0005374)2.05959899
96Premature skin wrinkling (HP:0100678)2.05864452
97Dysostosis multiplex (HP:0000943)2.05007055
98Slender long bone (HP:0003100)2.03624373
99Atresia of the external auditory canal (HP:0000413)2.03466412
100Secondary amenorrhea (HP:0000869)2.03297190
101Hypertensive crisis (HP:0100735)2.03035814
102Deviation of the thumb (HP:0009603)2.02533048
103Protrusio acetabuli (HP:0003179)2.02362231
104Missing ribs (HP:0000921)2.02083733
105Cafe-au-lait spot (HP:0000957)2.01989938
106Elbow flexion contracture (HP:0002987)2.01569423
107Ectopic kidney (HP:0000086)2.01265356
108Myopathic facies (HP:0002058)1.98524141
109Rib fusion (HP:0000902)1.97755441
110Hypokinesia (HP:0002375)1.97137664
111Cerebral inclusion bodies (HP:0100314)1.96561177
112Squamous cell carcinoma (HP:0002860)1.96210767
113Progressive external ophthalmoplegia (HP:0000590)1.96120978
114Neuronal loss in central nervous system (HP:0002529)1.96042803
115Mitral regurgitation (HP:0001653)1.94009916
116Abnormality of reticulocytes (HP:0004312)1.93980726
117Shoulder girdle muscle weakness (HP:0003547)1.93619632
118Increased density of long bones (HP:0006392)1.93024725
119Abnormality of pyrimidine metabolism (HP:0004353)1.92656253
120Neoplasm of striated muscle (HP:0009728)1.90512331
121Glioma (HP:0009733)1.90294519
122Prolonged neonatal jaundice (HP:0006579)1.90231520
123Nuclear cataract (HP:0100018)1.90183454
124Ureteral duplication (HP:0000073)1.89676228
125Tongue fasciculations (HP:0001308)1.89465692
126Upper motor neuron abnormality (HP:0002127)1.88384083
127Sloping forehead (HP:0000340)1.87202602
128Loss of speech (HP:0002371)1.86803154
129Long eyelashes (HP:0000527)1.86459174
130Abnormality of the musculature of the pelvis (HP:0001469)1.85803997
131Abnormality of the hip-girdle musculature (HP:0001445)1.85803997
132Abnormality of the thoracic spine (HP:0100711)1.85558552
133Bone marrow hypocellularity (HP:0005528)1.85522735
134Patellar dislocation (HP:0002999)1.84140936
135Interstitial pulmonary disease (HP:0006530)1.83549634
136Natal tooth (HP:0000695)1.83309014
137Flattened epiphyses (HP:0003071)1.81722565
138Overriding aorta (HP:0002623)1.81526587
139Personality changes (HP:0000751)1.80876802
140Cellulitis (HP:0100658)1.80203458
141Entropion (HP:0000621)1.80168731
142J-shaped sella turcica (HP:0002680)1.79863533
143Rectal prolapse (HP:0002035)1.79310496
144Lower limb amyotrophy (HP:0007210)1.78488674
145Adenoma sebaceum (HP:0009720)1.78419191
146Angiofibromas (HP:0010615)1.78419191
147Nonimmune hydrops fetalis (HP:0001790)1.77249956
148Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76711617
149Lymphoma (HP:0002665)1.75860657
150Aplasia/hypoplasia of the humerus (HP:0006507)1.75855343
151Microvesicular hepatic steatosis (HP:0001414)1.74331836
152Short clavicles (HP:0000894)1.72920964
153Acute lymphatic leukemia (HP:0006721)1.72847933
154Elfin facies (HP:0004428)1.72604136
155Preauricular skin tag (HP:0000384)1.71882735
156Pancytopenia (HP:0001876)1.71573818
157Gastrointestinal dysmotility (HP:0002579)1.71502403
158Fragile skin (HP:0001030)1.71298371
159Muscle fibrillation (HP:0010546)1.71269924
160Sparse lateral eyebrow (HP:0005338)1.71175186
161Annular pancreas (HP:0001734)1.71165922
162Hypoplasia of the pons (HP:0012110)1.70711533
163Small intestinal stenosis (HP:0012848)1.70215073
164Fasciculations (HP:0002380)1.69646305
165Hypercortisolism (HP:0001578)1.69319506
166Reduced subcutaneous adipose tissue (HP:0003758)1.68440626
167Abnormal gallbladder physiology (HP:0012438)1.68257498
168Cholecystitis (HP:0001082)1.68257498
169Polygenic inheritance (HP:0010982)1.67501236
170Spinal cord compression (HP:0002176)1.67019219
171Reticulocytosis (HP:0001923)1.66995115
172Abnormal umbilical cord blood vessels (HP:0011403)1.65131432
173Single umbilical artery (HP:0001195)1.65131432
174Abnormality of the fetal cardiovascular system (HP:0010948)1.65131432
175Centrally nucleated skeletal muscle fibers (HP:0003687)1.64020368
176Disproportionate tall stature (HP:0001519)1.63471595
177Thoracic kyphosis (HP:0002942)1.63372957
178Abnormality of the distal phalanx of the thumb (HP:0009617)1.62222482
179Biconcave vertebral bodies (HP:0004586)1.61958688
180Septate vagina (HP:0001153)1.61607891
181Hemorrhage of the eye (HP:0011885)1.61386087
182Diaphragmatic weakness (HP:0009113)1.60437961
183Bulbar palsy (HP:0001283)1.58825341
184Acanthosis nigricans (HP:0000956)1.58816837
185Spinal rigidity (HP:0003306)1.58612726
186Advanced eruption of teeth (HP:0006288)1.57914066
187Hypertriglyceridemia (HP:0002155)1.57750151
188Neurofibrillary tangles (HP:0002185)1.56397571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.09070974
2BUB13.69845969
3SMG13.63284584
4WEE13.17792634
5CDC73.14286788
6NEK23.04922944
7NME23.04547969
8PRPF4B2.77964725
9ACVR1B2.70667791
10EEF2K2.54488535
11EIF2AK12.37910221
12TSSK62.35968733
13RPS6KA42.29582117
14EPHA22.18963942
15CDK122.03879651
16NEK12.03794375
17MAP3K101.99869852
18MAP3K111.84717921
19PIM21.83953346
20CDK71.82877756
21TTK1.75069035
22SRPK11.74426368
23DYRK31.71232253
24ALK1.71219327
25TESK21.69610429
26TLK11.69157704
27MAP4K11.68359974
28CDK41.58858282
29SCYL21.51773619
30TAOK11.51370050
31PLK11.43316410
32VRK11.40477371
33VRK21.39170017
34ARAF1.38874991
35MST1R1.37489966
36PAK41.36503105
37TAOK21.35541805
38ATR1.34951546
39RIPK11.30630040
40RPS6KB21.30494579
41MAP3K81.29453582
42SIK21.28955463
43TRIB31.27045875
44TTN1.26459079
45CHEK11.21531588
46SIK31.21190967
47ZAP701.19646914
48LATS21.18507518
49AURKB1.18152961
50CHEK21.17172379
51TBK11.14218364
52IRAK21.12745802
53CDK81.05715884
54PLK41.03971636
55PLK31.03378052
56ABL21.02754964
57EIF2AK31.00951094
58PKN21.00502656
59PIM10.99844173
60AURKA0.98624013
61MKNK10.98585924
62STK100.94948785
63PASK0.94848409
64CDK20.92585063
65IRAK40.90015984
66PRKD20.88757605
67BRAF0.86578658
68SIK10.86351020
69PRKD30.86087243
70MAP2K20.85511390
71BRD40.83694736
72MKNK20.83559390
73MTOR0.82535351
74CDK60.82516908
75LMTK20.82116396
76RAF10.81480757
77MAP3K130.80328738
78MARK30.77743396
79PAK20.77480797
80RPS6KC10.73796358
81RPS6KL10.73796358
82BRSK20.71941642
83MAP3K10.70292227
84STK160.70082069
85MAP3K140.70026841
86CSNK2A20.69910668
87LIMK10.68990553
88BRSK10.68529876
89JAK30.68328843
90CCNB10.68276700
91ILK0.68004856
92RPS6KA20.65296029
93PTK60.64922084
94IKBKB0.63989133
95PTK20.63461503
96ZAK0.63033255
97LRRK20.62344940
98PDPK10.62249812
99ATM0.62027989
100ICK0.61857659
101CDC42BPA0.61255100
102CSNK1E0.60420093
103MAP3K30.60007899
104PAK10.59696885
105TGFBR10.59122069
106BMX0.58736478
107TXK0.58056108
108DDR20.57828595
109KDR0.56355182
110TYK20.55895626
111AKT20.55551374
112DAPK30.55299348
113FLT30.55186975
114MOS0.55107441
115MAP2K30.52597843
116ERN10.51904245
117RPS6KA60.51702228
118CSNK2A10.51326606
119PDGFRA0.50437034
120PBK0.49913254
121MARK20.47408528
122GRK60.46408642
123PRKCI0.46155263
124CDK10.46055825
125DAPK10.43830034
126CDK90.43629329
127MAPKAPK20.41782103
128MATK0.40864281
129FGFR40.40727702
130RPS6KA10.38281230
131CAMKK10.35591953
132RPS6KA50.35261752
133HIPK20.34756199
134MAPK110.34149692
135CHUK0.33241626
136MAP3K50.32781464
137MAPK90.31429343
138MAPKAPK30.30802434
139NME10.29277094
140STK40.29037390
141BCKDK0.28102844
142MELK0.26862113
143TESK10.26544440
144PRKDC0.26197823
145MAPK140.25500660

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.54263889
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.39048195
3Mismatch repair_Homo sapiens_hsa034303.66035736
4Spliceosome_Homo sapiens_hsa030403.50596253
5RNA transport_Homo sapiens_hsa030133.41160010
6Ribosome_Homo sapiens_hsa030103.16540678
7One carbon pool by folate_Homo sapiens_hsa006703.07371511
8Base excision repair_Homo sapiens_hsa034102.85698167
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.84754613
10Other glycan degradation_Homo sapiens_hsa005112.81923093
11RNA polymerase_Homo sapiens_hsa030202.79002193
12Proteasome_Homo sapiens_hsa030502.47013845
13Homologous recombination_Homo sapiens_hsa034402.34948937
14Cell cycle_Homo sapiens_hsa041102.27765600
15Pyrimidine metabolism_Homo sapiens_hsa002402.26500062
16Nucleotide excision repair_Homo sapiens_hsa034202.20498492
17mRNA surveillance pathway_Homo sapiens_hsa030151.87426531
18RNA degradation_Homo sapiens_hsa030181.64129744
19p53 signaling pathway_Homo sapiens_hsa041151.60674239
20Fanconi anemia pathway_Homo sapiens_hsa034601.60335994
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.40756715
22Folate biosynthesis_Homo sapiens_hsa007901.40523770
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38292682
24Prion diseases_Homo sapiens_hsa050201.31648706
25Sulfur relay system_Homo sapiens_hsa041221.30747287
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30565038
27Pancreatic cancer_Homo sapiens_hsa052121.24118547
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23052466
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.22434206
30Basal transcription factors_Homo sapiens_hsa030221.22245179
31Lysosome_Homo sapiens_hsa041421.22079906
32Epstein-Barr virus infection_Homo sapiens_hsa051691.21273451
33TNF signaling pathway_Homo sapiens_hsa046681.19253780
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.14908102
35Pentose phosphate pathway_Homo sapiens_hsa000301.14863664
36Biosynthesis of amino acids_Homo sapiens_hsa012301.14732900
37Viral carcinogenesis_Homo sapiens_hsa052031.05564473
38HTLV-I infection_Homo sapiens_hsa051661.03542286
39Thyroid cancer_Homo sapiens_hsa052161.02929188
40Purine metabolism_Homo sapiens_hsa002301.01738639
41Antigen processing and presentation_Homo sapiens_hsa046121.01582344
42Herpes simplex infection_Homo sapiens_hsa051681.00354444
43Hepatitis C_Homo sapiens_hsa051600.99122989
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98122512
45Vibrio cholerae infection_Homo sapiens_hsa051100.96973881
46Acute myeloid leukemia_Homo sapiens_hsa052210.94586650
47Selenocompound metabolism_Homo sapiens_hsa004500.91968227
48Osteoclast differentiation_Homo sapiens_hsa043800.91123651
49Chronic myeloid leukemia_Homo sapiens_hsa052200.87519551
50Non-homologous end-joining_Homo sapiens_hsa034500.86345113
51Systemic lupus erythematosus_Homo sapiens_hsa053220.85407177
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85116249
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.84981394
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84006721
55Salmonella infection_Homo sapiens_hsa051320.82736164
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81702593
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81613564
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77953572
59Bladder cancer_Homo sapiens_hsa052190.76911458
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73744459
61Hepatitis B_Homo sapiens_hsa051610.73702426
62Oocyte meiosis_Homo sapiens_hsa041140.73469872
63Toxoplasmosis_Homo sapiens_hsa051450.72922853
64Insulin signaling pathway_Homo sapiens_hsa049100.72728240
65mTOR signaling pathway_Homo sapiens_hsa041500.72627884
66MicroRNAs in cancer_Homo sapiens_hsa052060.72417267
67Glioma_Homo sapiens_hsa052140.69704622
68Primary immunodeficiency_Homo sapiens_hsa053400.67554813
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66868664
70AMPK signaling pathway_Homo sapiens_hsa041520.66169145
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.65820001
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65633069
73Small cell lung cancer_Homo sapiens_hsa052220.65527467
74Vitamin B6 metabolism_Homo sapiens_hsa007500.65480593
75Glutathione metabolism_Homo sapiens_hsa004800.65007235
76Colorectal cancer_Homo sapiens_hsa052100.61368335
77Shigellosis_Homo sapiens_hsa051310.60656742
78ErbB signaling pathway_Homo sapiens_hsa040120.59879773
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.59857740
80Apoptosis_Homo sapiens_hsa042100.59456489
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58926538
82Renal cell carcinoma_Homo sapiens_hsa052110.58179475
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54455939
84Legionellosis_Homo sapiens_hsa051340.54080331
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.52657472
86Measles_Homo sapiens_hsa051620.52657053
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.50843011
88N-Glycan biosynthesis_Homo sapiens_hsa005100.50555202
89Endocytosis_Homo sapiens_hsa041440.50479184
90Proteoglycans in cancer_Homo sapiens_hsa052050.49891448
91Notch signaling pathway_Homo sapiens_hsa043300.49572173
92HIF-1 signaling pathway_Homo sapiens_hsa040660.49564125
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49441936
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49137195
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48586670
96Fructose and mannose metabolism_Homo sapiens_hsa000510.48463632
97T cell receptor signaling pathway_Homo sapiens_hsa046600.47817939
98Phenylalanine metabolism_Homo sapiens_hsa003600.46900182
99Hippo signaling pathway_Homo sapiens_hsa043900.45068940
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43908539
101Non-small cell lung cancer_Homo sapiens_hsa052230.41069252
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35176433
103Alcoholism_Homo sapiens_hsa050340.34948253
104B cell receptor signaling pathway_Homo sapiens_hsa046620.33792374
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33121923
106TGF-beta signaling pathway_Homo sapiens_hsa043500.30806005
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30606720
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30467363
109Influenza A_Homo sapiens_hsa051640.29964582
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.29858114
111VEGF signaling pathway_Homo sapiens_hsa043700.29093454
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28095699
113Prolactin signaling pathway_Homo sapiens_hsa049170.28070234
114Carbon metabolism_Homo sapiens_hsa012000.27799059
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27306981
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27252874
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26621525
118Leishmaniasis_Homo sapiens_hsa051400.26610620
119Galactose metabolism_Homo sapiens_hsa000520.26458949
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25676988
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25592359
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24165025
123Wnt signaling pathway_Homo sapiens_hsa043100.23079029
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.22790657
125Endometrial cancer_Homo sapiens_hsa052130.22570934
126Hematopoietic cell lineage_Homo sapiens_hsa046400.22188569
127Pathways in cancer_Homo sapiens_hsa052000.22106003
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20793177
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20770767
130Prostate cancer_Homo sapiens_hsa052150.19316088
131Basal cell carcinoma_Homo sapiens_hsa052170.19085055

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