TRMT61B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.12092257
2DNA damage response, detection of DNA damage (GO:0042769)4.75033532
3respiratory chain complex IV assembly (GO:0008535)4.48795134
4replication fork processing (GO:0031297)4.12034369
5proteasome assembly (GO:0043248)4.02030043
6chromatin remodeling at centromere (GO:0031055)3.93126866
7CENP-A containing nucleosome assembly (GO:0034080)3.92611225
8cullin deneddylation (GO:0010388)3.86676135
9cytochrome complex assembly (GO:0017004)3.86671640
10regulation of helicase activity (GO:0051095)3.76044616
11protein deneddylation (GO:0000338)3.71144260
12protein complex biogenesis (GO:0070271)3.67504131
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63747188
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.63747188
15NADH dehydrogenase complex assembly (GO:0010257)3.63747188
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.59415048
17RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.59415048
18mitochondrial respiratory chain complex assembly (GO:0033108)3.54623679
19DNA catabolic process, exonucleolytic (GO:0000738)3.54474694
20rRNA modification (GO:0000154)3.48588388
21maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.47148089
22histone exchange (GO:0043486)3.40081417
23pseudouridine synthesis (GO:0001522)3.29038744
24DNA replication checkpoint (GO:0000076)3.24704183
25histone H2A acetylation (GO:0043968)3.23517700
26DNA ligation (GO:0006266)3.20282452
27ribosome assembly (GO:0042255)3.19543637
28somatic hypermutation of immunoglobulin genes (GO:0016446)3.16855408
29somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16855408
30regulation of mitotic spindle checkpoint (GO:1903504)3.12558671
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12558671
32DNA replication-independent nucleosome assembly (GO:0006336)3.08911454
33DNA replication-independent nucleosome organization (GO:0034724)3.08911454
34resolution of meiotic recombination intermediates (GO:0000712)3.04929896
35platelet dense granule organization (GO:0060155)3.04347708
36branched-chain amino acid catabolic process (GO:0009083)3.01969530
37water-soluble vitamin biosynthetic process (GO:0042364)2.98398232
38establishment of integrated proviral latency (GO:0075713)2.97453888
39negative regulation of DNA-dependent DNA replication (GO:2000104)2.95067124
40RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.94197989
41postreplication repair (GO:0006301)2.93565700
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92580564
43DNA replication-dependent nucleosome assembly (GO:0006335)2.91290931
44DNA replication-dependent nucleosome organization (GO:0034723)2.91290931
45regulation of mitochondrial translation (GO:0070129)2.91037071
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89830862
47* mitochondrial RNA metabolic process (GO:0000959)2.88424268
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87818802
49rRNA methylation (GO:0031167)2.87243116
50kinetochore organization (GO:0051383)2.86923080
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86682387
52IMP biosynthetic process (GO:0006188)2.84750366
53purine nucleobase biosynthetic process (GO:0009113)2.80430259
54kinetochore assembly (GO:0051382)2.78925106
55peptidyl-histidine modification (GO:0018202)2.78636677
56maturation of 5.8S rRNA (GO:0000460)2.78327337
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78327244
58recombinational repair (GO:0000725)2.76584360
59regulation of meiosis I (GO:0060631)2.75881925
60isotype switching (GO:0045190)2.75877398
61somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75877398
62somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75877398
63non-recombinational repair (GO:0000726)2.74836862
64double-strand break repair via nonhomologous end joining (GO:0006303)2.74836862
65negative regulation of telomere maintenance (GO:0032205)2.74022875
66double-strand break repair via homologous recombination (GO:0000724)2.70848446
67DNA-dependent DNA replication (GO:0006261)2.69542554
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65777330
69nucleobase biosynthetic process (GO:0046112)2.61418255
70male meiosis (GO:0007140)2.61179619
71negative regulation of DNA recombination (GO:0045910)2.61104325
72termination of RNA polymerase I transcription (GO:0006363)2.60764373
73prenylation (GO:0097354)2.60004664
74protein prenylation (GO:0018342)2.60004664
75protein-cofactor linkage (GO:0018065)2.58802132
76regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58348644
77protein K11-linked ubiquitination (GO:0070979)2.57826103
78preassembly of GPI anchor in ER membrane (GO:0016254)2.56308609
79viral mRNA export from host cell nucleus (GO:0046784)2.55329757
80histone mRNA metabolic process (GO:0008334)2.55286910
81termination of RNA polymerase III transcription (GO:0006386)2.53077947
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.53077947
83transcription from mitochondrial promoter (GO:0006390)2.52634031
84telomere maintenance via semi-conservative replication (GO:0032201)2.51314285
85* tRNA processing (GO:0008033)2.48917669
86intraciliary transport (GO:0042073)2.48750317
87synapsis (GO:0007129)2.48497907
88response to X-ray (GO:0010165)2.48450870
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.48293948
90response to pheromone (GO:0019236)2.48147014
91mismatch repair (GO:0006298)2.47927749
92regulation of cellular amino acid metabolic process (GO:0006521)2.47913449
93protein localization to kinetochore (GO:0034501)2.47453488
94mitotic spindle checkpoint (GO:0071174)2.46642921
95mitochondrial DNA replication (GO:0006264)2.46620558
96telomere maintenance via telomerase (GO:0007004)2.46029677
97branched-chain amino acid metabolic process (GO:0009081)2.45288172
98spindle checkpoint (GO:0031577)2.44665991
99negative regulation of ligase activity (GO:0051352)2.43480361
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.43480361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25350435
2E2F7_22180533_ChIP-Seq_HELA_Human3.79198778
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.52317847
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36106061
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.25806713
6ZNF274_21170338_ChIP-Seq_K562_Hela2.88516035
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79273827
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.73475673
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70886400
10* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69946385
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.69942995
12ELK1_19687146_ChIP-ChIP_HELA_Human2.63816291
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53573025
14VDR_22108803_ChIP-Seq_LS180_Human2.48128219
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45710671
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37090951
17IGF1R_20145208_ChIP-Seq_DFB_Human2.32701175
18FUS_26573619_Chip-Seq_HEK293_Human2.29762949
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15005846
20EWS_26573619_Chip-Seq_HEK293_Human2.14650234
21* VDR_23849224_ChIP-Seq_CD4+_Human2.09642958
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09317684
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.05897930
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04774237
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.03989157
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97581633
27GBX2_23144817_ChIP-Seq_PC3_Human1.95743771
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92385703
29TAF15_26573619_Chip-Seq_HEK293_Human1.92380788
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85080895
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81286524
32FOXP3_21729870_ChIP-Seq_TREG_Human1.81068363
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.67669967
34MYC_18940864_ChIP-ChIP_HL60_Human1.66482192
35P300_19829295_ChIP-Seq_ESCs_Human1.66184825
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.63606108
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63106766
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62559933
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58793220
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58767269
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54218978
42* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51839879
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50369536
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49544216
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47209074
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45734145
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38385833
48IRF1_19129219_ChIP-ChIP_H3396_Human1.36866606
49* DCP1A_22483619_ChIP-Seq_HELA_Human1.34893268
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31987213
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.31210464
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27140480
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.25098772
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24585811
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23647297
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.22829153
57GABP_19822575_ChIP-Seq_HepG2_Human1.21322622
58ER_23166858_ChIP-Seq_MCF-7_Human1.20407744
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20036978
60TP53_22573176_ChIP-Seq_HFKS_Human1.15369624
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15283582
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14757684
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14480207
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.13186461
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11723810
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11065295
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09869560
68CBP_20019798_ChIP-Seq_JUKART_Human1.09869560
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07984162
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07688834
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07259874
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06003390
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05966297
74TTF2_22483619_ChIP-Seq_HELA_Human1.04457324
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04288956
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03479524
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.02850506
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02480083
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02101392
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01917089
81SMAD4_21799915_ChIP-Seq_A2780_Human1.01398424
82SOX2_16153702_ChIP-ChIP_HESCs_Human0.99611843
83CRX_20693478_ChIP-Seq_RETINA_Mouse0.97222898
84YY1_21170310_ChIP-Seq_MESCs_Mouse0.96962282
85SOX2_19829295_ChIP-Seq_ESCs_Human0.95957299
86NANOG_19829295_ChIP-Seq_ESCs_Human0.95957299
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94781724
88THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94324266
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93247790
90STAT3_23295773_ChIP-Seq_U87_Human0.92979018
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92458042
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91751437
93* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91242471
94BCAT_22108803_ChIP-Seq_LS180_Human0.91039289
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.90789314
96PIAS1_25552417_ChIP-Seq_VCAP_Human0.90724439
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90508657
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90370830
99FOXM1_23109430_ChIP-Seq_U2OS_Human0.89335235
100AR_21909140_ChIP-Seq_LNCAP_Human0.88289734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.28478104
2MP0008058_abnormal_DNA_repair3.10435782
3MP0010094_abnormal_chromosome_stability3.03474862
4MP0003195_calcinosis2.61590248
5MP0000372_irregular_coat_pigmentation2.58367369
6MP0002938_white_spotting2.43011486
7MP0006292_abnormal_olfactory_placode2.35003278
8MP0003693_abnormal_embryo_hatching2.34305144
9MP0008877_abnormal_DNA_methylation2.33681330
10MP0001529_abnormal_vocalization2.27421338
11MP0009697_abnormal_copulation2.23963275
12MP0002736_abnormal_nociception_after2.22940219
13MP0003718_maternal_effect2.11754225
14MP0003806_abnormal_nucleotide_metabolis2.11314490
15MP0004957_abnormal_blastocyst_morpholog2.07631264
16MP0006072_abnormal_retinal_apoptosis1.93733242
17MP0003111_abnormal_nucleus_morphology1.90755595
18MP0002234_abnormal_pharynx_morphology1.80765755
19MP0005551_abnormal_eye_electrophysiolog1.80535752
20MP0008789_abnormal_olfactory_epithelium1.66154703
21MP0003786_premature_aging1.63944188
22MP0003077_abnormal_cell_cycle1.63731342
23MP0008995_early_reproductive_senescence1.61158485
24MP0008057_abnormal_DNA_replication1.60138914
25MP0001293_anophthalmia1.58549575
26MP0000516_abnormal_urinary_system1.57935354
27MP0005367_renal/urinary_system_phenotyp1.57935354
28MP0006276_abnormal_autonomic_nervous1.52983581
29MP0003890_abnormal_embryonic-extraembry1.51905840
30MP0004147_increased_porphyrin_level1.49912506
31MP0002837_dystrophic_cardiac_calcinosis1.48770788
32MP0008932_abnormal_embryonic_tissue1.48428179
33MP0001984_abnormal_olfaction1.46903094
34MP0003136_yellow_coat_color1.46393359
35MP0008007_abnormal_cellular_replicative1.45858322
36MP0003186_abnormal_redox_activity1.45645540
37MP0008872_abnormal_physiological_respon1.43436616
38MP0005253_abnormal_eye_physiology1.43411919
39MP0005075_abnormal_melanosome_morpholog1.41841922
40MP0001968_abnormal_touch/_nociception1.38955777
41MP0000631_abnormal_neuroendocrine_gland1.35593042
42MP0003121_genomic_imprinting1.28926222
43MP0000569_abnormal_digit_pigmentation1.28612166
44MP0004133_heterotaxia1.27592623
45MP0001764_abnormal_homeostasis1.27095395
46MP0002751_abnormal_autonomic_nervous1.24736832
47MP0005646_abnormal_pituitary_gland1.24334568
48MP0003880_abnormal_central_pattern1.22634717
49MP0002163_abnormal_gland_morphology1.21667737
50MP0001929_abnormal_gametogenesis1.20617334
51MP0003122_maternal_imprinting1.20213885
52MP0005645_abnormal_hypothalamus_physiol1.20040937
53MP0005084_abnormal_gallbladder_morpholo1.17041621
54MP0002638_abnormal_pupillary_reflex1.15914558
55MP0000427_abnormal_hair_cycle1.15805771
56MP0005394_taste/olfaction_phenotype1.15793477
57MP0005499_abnormal_olfactory_system1.15793477
58MP0003567_abnormal_fetal_cardiomyocyte1.14093759
59MP0002090_abnormal_vision1.11143244
60MP0006036_abnormal_mitochondrial_physio1.10582730
61MP0000647_abnormal_sebaceous_gland1.10401541
62MP0003937_abnormal_limbs/digits/tail_de1.10379588
63MP0004215_abnormal_myocardial_fiber1.09395208
64MP0001661_extended_life_span1.08538819
65MP0002233_abnormal_nose_morphology1.07953007
66MP0002210_abnormal_sex_determination1.03996816
67MP0000653_abnormal_sex_gland1.01591589
68MP0005379_endocrine/exocrine_gland_phen1.01567855
69MP0006035_abnormal_mitochondrial_morpho1.01218281
70MP0001145_abnormal_male_reproductive0.96111150
71MP0003119_abnormal_digestive_system0.95473852
72MP0001286_abnormal_eye_development0.94183024
73MP0008875_abnormal_xenobiotic_pharmacok0.94025796
74MP0005408_hypopigmentation0.93923373
75MP0003698_abnormal_male_reproductive0.91418624
76MP0005332_abnormal_amino_acid0.91032653
77MP0005195_abnormal_posterior_eye0.88364221
78MP0005410_abnormal_fertilization0.87860898
79MP0005395_other_phenotype0.86433004
80MP0001324_abnormal_eye_pigmentation0.83713808
81MP0002160_abnormal_reproductive_system0.83671174
82MP0001485_abnormal_pinna_reflex0.82262497
83MP0001119_abnormal_female_reproductive0.79386943
84MP0005391_vision/eye_phenotype0.79073070
85MP0000383_abnormal_hair_follicle0.77036365
86MP0001697_abnormal_embryo_size0.76941669
87MP0000778_abnormal_nervous_system0.76676003
88MP0004197_abnormal_fetal_growth/weight/0.75457367
89MP0002127_abnormal_cardiovascular_syste0.73010396
90MP0002084_abnormal_developmental_patter0.72338157
91MP0005389_reproductive_system_phenotype0.72258251
92MP0000358_abnormal_cell_content/0.71112543
93MP0010030_abnormal_orbit_morphology0.70191932
94MP0009703_decreased_birth_body0.68738539
95MP0001486_abnormal_startle_reflex0.68466134
96MP0002282_abnormal_trachea_morphology0.67529374
97MP0009046_muscle_twitch0.65789006
98MP0003787_abnormal_imprinting0.64924107
99MP0001672_abnormal_embryogenesis/_devel0.64613748
100MP0005380_embryogenesis_phenotype0.64613748

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.58642741
2Increased CSF lactate (HP:0002490)3.01125995
3Methylmalonic acidemia (HP:0002912)2.97987343
4True hermaphroditism (HP:0010459)2.89526848
5Hyperglycinemia (HP:0002154)2.88625832
6Molar tooth sign on MRI (HP:0002419)2.86030404
7Abnormality of midbrain morphology (HP:0002418)2.86030404
8Colon cancer (HP:0003003)2.85921939
9Pancreatic cysts (HP:0001737)2.82987533
10Hepatocellular necrosis (HP:0001404)2.76831742
11Acute encephalopathy (HP:0006846)2.72183780
12Acute necrotizing encephalopathy (HP:0006965)2.71481524
13Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.70012402
14Abnormal protein N-linked glycosylation (HP:0012347)2.70012402
15Abnormal protein glycosylation (HP:0012346)2.70012402
16Abnormal glycosylation (HP:0012345)2.70012402
17Mitochondrial inheritance (HP:0001427)2.68140382
18Increased serum pyruvate (HP:0003542)2.67202443
19Meckel diverticulum (HP:0002245)2.66519129
20Pancreatic fibrosis (HP:0100732)2.66398598
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.64888188
22Hepatic necrosis (HP:0002605)2.62767747
23Abnormality of the ileum (HP:0001549)2.59918728
24Medial flaring of the eyebrow (HP:0010747)2.53100848
25Progressive macrocephaly (HP:0004481)2.52064084
26Reduced antithrombin III activity (HP:0001976)2.46020027
27Abnormal mitochondria in muscle tissue (HP:0008316)2.44376503
28Abolished electroretinogram (ERG) (HP:0000550)2.41012176
29Methylmalonic aciduria (HP:0012120)2.40618177
30Abnormality of glycolysis (HP:0004366)2.37428891
31Abnormality of chromosome stability (HP:0003220)2.35809477
32Increased serum lactate (HP:0002151)2.34178980
33Nephronophthisis (HP:0000090)2.32770432
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31246492
35Abnormality of alanine metabolism (HP:0010916)2.31246492
36Hyperalaninemia (HP:0003348)2.31246492
37Pancreatic islet-cell hyperplasia (HP:0004510)2.30964246
38Abnormality of the preputium (HP:0100587)2.30569334
39Type I transferrin isoform profile (HP:0003642)2.30239168
40Renal cortical cysts (HP:0000803)2.29400467
41Small intestinal stenosis (HP:0012848)2.28356362
42Duodenal stenosis (HP:0100867)2.28356362
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27918803
44Abnormality of serum amino acid levels (HP:0003112)2.26223136
45Abnormal lung lobation (HP:0002101)2.22411260
46Abnormality of glycine metabolism (HP:0010895)2.16744543
47Abnormality of serine family amino acid metabolism (HP:0010894)2.16744543
48Short tibia (HP:0005736)2.15038668
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.14987064
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.12958232
51Abnormality of the duodenum (HP:0002246)2.12609143
52Cerebral edema (HP:0002181)2.11065829
53Lactic acidosis (HP:0003128)2.10610577
54Ependymoma (HP:0002888)2.09539545
55Chromsome breakage (HP:0040012)2.04665013
56Hyperglycinuria (HP:0003108)2.02935181
57Degeneration of anterior horn cells (HP:0002398)2.02500962
58Abnormality of the anterior horn cell (HP:0006802)2.02500962
59Sloping forehead (HP:0000340)2.01460870
60Increased hepatocellular lipid droplets (HP:0006565)2.00310897
61Abnormality of the renal cortex (HP:0011035)2.00209401
62Pendular nystagmus (HP:0012043)1.99870234
63Bifid tongue (HP:0010297)1.98930996
64Congenital primary aphakia (HP:0007707)1.97972531
65Intestinal atresia (HP:0011100)1.97859601
66Nephrogenic diabetes insipidus (HP:0009806)1.96473768
67Congenital stationary night blindness (HP:0007642)1.93991030
68Lipid accumulation in hepatocytes (HP:0006561)1.93912246
69Retinal dysplasia (HP:0007973)1.93107540
70Small hand (HP:0200055)1.92511828
71Gait imbalance (HP:0002141)1.91346258
72Chronic hepatic failure (HP:0100626)1.91326410
73Genital tract atresia (HP:0001827)1.91167516
74Volvulus (HP:0002580)1.90635632
75Abnormality of the renal medulla (HP:0100957)1.84255630
76Gastrointestinal atresia (HP:0002589)1.83462578
77Sclerocornea (HP:0000647)1.82977235
78Abnormality of the metopic suture (HP:0005556)1.81976361
79Attenuation of retinal blood vessels (HP:0007843)1.81392760
80Abnormality of macular pigmentation (HP:0008002)1.79703646
81Lethargy (HP:0001254)1.79088680
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78994361
83Abnormality of the vitamin B12 metabolism (HP:0004341)1.78893202
84Neoplasm of the adrenal cortex (HP:0100641)1.78681934
85Abnormality of vitamin B metabolism (HP:0004340)1.78596744
86Embryonal renal neoplasm (HP:0011794)1.77796739
87Nephroblastoma (Wilms tumor) (HP:0002667)1.76019019
88Oculomotor apraxia (HP:0000657)1.75075801
89Vaginal atresia (HP:0000148)1.74965180
90CNS demyelination (HP:0007305)1.73902871
91Hypoglycemic coma (HP:0001325)1.72328099
92Atrophy/Degeneration involving motor neurons (HP:0007373)1.71384255
93Progressive inability to walk (HP:0002505)1.70830346
94Postaxial hand polydactyly (HP:0001162)1.70051060
95Progressive microcephaly (HP:0000253)1.69915018
96Dandy-Walker malformation (HP:0001305)1.69195709
97Hyperinsulinemic hypoglycemia (HP:0000825)1.69001677
98Triphalangeal thumb (HP:0001199)1.68820079
99Type 2 muscle fiber atrophy (HP:0003554)1.68410846
100Neoplasm of the adrenal gland (HP:0100631)1.67330033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.91874335
2NUAK13.59243068
3MAP4K23.58527132
4EIF2AK33.46375423
5FRK2.95213363
6TRIM282.41943405
7VRK22.17415092
8SRPK12.15606232
9BUB12.14703851
10WNK32.07487983
11BMPR1B2.06902573
12WEE12.04761187
13ZAK2.03699941
14ERBB32.00432201
15LATS11.98577961
16BRSK21.92698058
17PLK31.90841072
18TNIK1.87996142
19MST41.85152645
20MKNK21.81044975
21EIF2AK11.74787058
22NEK11.74680493
23BCR1.72037724
24MKNK11.71269285
25VRK11.59175475
26CDC71.48143317
27PBK1.44851858
28TSSK61.39995117
29MAP3K41.39344903
30PLK21.36402439
31MAPK131.35349264
32TTK1.32643393
33TAF11.22987809
34STK161.21543349
35ACVR1B1.20812934
36STK31.19523927
37PLK41.16671431
38FGFR21.16569896
39EIF2AK21.15915639
40BCKDK1.15800791
41STK38L1.11996415
42NME11.11219880
43PDK21.09439937
44PLK11.07874448
45CASK1.06322792
46CSNK1G11.05977946
47MAP2K71.04887291
48PINK11.03489758
49ADRBK21.02941569
50DYRK20.98301679
51CSNK1G30.90989493
52TLK10.89512321
53CSNK1G20.87108124
54CHEK20.84693059
55FLT30.84112514
56BRSK10.81523388
57GRK10.80315023
58EPHA40.77330597
59CCNB10.76990181
60OXSR10.76329890
61CSNK1A1L0.72682851
62ATR0.71320472
63TAOK20.69625459
64STK390.68294688
65PAK30.65016495
66PRKCE0.59311478
67BRD40.58250416
68ATM0.54367529
69MAP2K60.53431899
70TGFBR10.51754926
71MAP3K120.48762441
72AURKB0.46821775
73PNCK0.44216630
74DAPK10.43800805
75PRKCG0.42733004
76FER0.41429134
77PASK0.39440108
78DYRK30.36996027
79RPS6KB20.36951555
80MAPKAPK50.35074141
81CHEK10.34243811
82MARK10.34236522
83MAPKAPK30.33764936
84CSNK2A20.33352485
85CSNK2A10.32780658
86CSNK1A10.31820882
87PKN10.30960416
88MAP3K50.30642121
89PRKACB0.29370196
90ADRBK10.28700613
91MINK10.28291502
92OBSCN0.27192549
93NEK20.26755628
94MUSK0.26314357
95YES10.26188774
96FGFR10.25460316
97CDK80.24817987
98NLK0.24663550
99RPS6KA40.24460360
100ERBB40.23591901

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.35700453
2Protein export_Homo sapiens_hsa030603.32864634
3Non-homologous end-joining_Homo sapiens_hsa034502.76468825
4RNA polymerase_Homo sapiens_hsa030202.66316558
5Mismatch repair_Homo sapiens_hsa034302.63420698
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58041610
7Propanoate metabolism_Homo sapiens_hsa006402.46425127
8Homologous recombination_Homo sapiens_hsa034402.45357336
9DNA replication_Homo sapiens_hsa030302.35797485
10Fanconi anemia pathway_Homo sapiens_hsa034602.31289477
11Basal transcription factors_Homo sapiens_hsa030222.26421457
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05202548
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00196208
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93959915
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92908364
16Oxidative phosphorylation_Homo sapiens_hsa001901.86943542
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84180397
18Fatty acid elongation_Homo sapiens_hsa000621.76700280
19RNA transport_Homo sapiens_hsa030131.71111356
20Spliceosome_Homo sapiens_hsa030401.71012245
21RNA degradation_Homo sapiens_hsa030181.69993138
22Base excision repair_Homo sapiens_hsa034101.68052651
23Parkinsons disease_Homo sapiens_hsa050121.66769001
24Butanoate metabolism_Homo sapiens_hsa006501.65123701
25Nucleotide excision repair_Homo sapiens_hsa034201.61863278
26One carbon pool by folate_Homo sapiens_hsa006701.55456044
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51946037
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51248499
29Pyrimidine metabolism_Homo sapiens_hsa002401.50551929
30Phototransduction_Homo sapiens_hsa047441.45097880
31Selenocompound metabolism_Homo sapiens_hsa004501.41478642
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.41029301
33Steroid biosynthesis_Homo sapiens_hsa001001.36962831
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34097932
35Purine metabolism_Homo sapiens_hsa002301.32153549
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31429595
37Cell cycle_Homo sapiens_hsa041101.21268922
38Glutathione metabolism_Homo sapiens_hsa004801.19869930
39Huntingtons disease_Homo sapiens_hsa050161.18688820
40Pyruvate metabolism_Homo sapiens_hsa006201.18552893
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07864712
42Peroxisome_Homo sapiens_hsa041461.07415115
43Regulation of autophagy_Homo sapiens_hsa041401.06019199
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02999706
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.01411915
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01366019
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00601272
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94804343
49Tryptophan metabolism_Homo sapiens_hsa003800.93091105
50mRNA surveillance pathway_Homo sapiens_hsa030150.90114343
51Linoleic acid metabolism_Homo sapiens_hsa005910.86322788
52Oocyte meiosis_Homo sapiens_hsa041140.86023307
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82456643
54Alzheimers disease_Homo sapiens_hsa050100.82439516
55Metabolic pathways_Homo sapiens_hsa011000.82325103
56Ribosome_Homo sapiens_hsa030100.81319632
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81183041
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80733708
59Nitrogen metabolism_Homo sapiens_hsa009100.78709122
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78145853
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76867893
62Fatty acid metabolism_Homo sapiens_hsa012120.75324418
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.71378791
64p53 signaling pathway_Homo sapiens_hsa041150.70800579
65Ether lipid metabolism_Homo sapiens_hsa005650.70768580
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69966605
67beta-Alanine metabolism_Homo sapiens_hsa004100.69849666
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68575268
69Nicotine addiction_Homo sapiens_hsa050330.67427772
70Vitamin B6 metabolism_Homo sapiens_hsa007500.65386981
71Chemical carcinogenesis_Homo sapiens_hsa052040.64659917
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64480391
73Folate biosynthesis_Homo sapiens_hsa007900.63824320
74Caffeine metabolism_Homo sapiens_hsa002320.63222871
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63167683
76Carbon metabolism_Homo sapiens_hsa012000.61851085
77Fatty acid degradation_Homo sapiens_hsa000710.61382007
78N-Glycan biosynthesis_Homo sapiens_hsa005100.60357445
79Retinol metabolism_Homo sapiens_hsa008300.59952712
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59772741
81Olfactory transduction_Homo sapiens_hsa047400.58337053
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57470208
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.54686249
84Arachidonic acid metabolism_Homo sapiens_hsa005900.52500293
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51705788
86Taste transduction_Homo sapiens_hsa047420.50795437
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46900305
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45151221
89Biosynthesis of amino acids_Homo sapiens_hsa012300.43842273
90Fat digestion and absorption_Homo sapiens_hsa049750.43387835
91Collecting duct acid secretion_Homo sapiens_hsa049660.41909856
92Cardiac muscle contraction_Homo sapiens_hsa042600.39892164
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39374462
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38087664
95Sulfur metabolism_Homo sapiens_hsa009200.38015558
96Arginine and proline metabolism_Homo sapiens_hsa003300.35193899
97Hedgehog signaling pathway_Homo sapiens_hsa043400.34215435
98Vitamin digestion and absorption_Homo sapiens_hsa049770.33080589
99Starch and sucrose metabolism_Homo sapiens_hsa005000.30832381
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29051694

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