TRMU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)5.40899589
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.89887176
3nuclear pore complex assembly (GO:0051292)4.86479977
4ribosomal small subunit biogenesis (GO:0042274)4.82000917
5inner mitochondrial membrane organization (GO:0007007)4.73830729
6viral transcription (GO:0019083)4.70103181
7mitochondrial respiratory chain complex I assembly (GO:0032981)4.62462927
8NADH dehydrogenase complex assembly (GO:0010257)4.62462927
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.62462927
10mitotic sister chromatid segregation (GO:0000070)4.56423851
11protein complex biogenesis (GO:0070271)4.51831601
12oxidative phosphorylation (GO:0006119)4.48776514
13translational termination (GO:0006415)4.45635244
14ATP synthesis coupled proton transport (GO:0015986)4.38399542
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38399542
16spliceosomal tri-snRNP complex assembly (GO:0000244)4.31824610
17mitochondrial respiratory chain complex assembly (GO:0033108)4.28293776
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.17988960
19sister chromatid segregation (GO:0000819)4.15541413
20DNA deamination (GO:0045006)4.14184849
21DNA replication initiation (GO:0006270)4.13727716
22protoporphyrinogen IX biosynthetic process (GO:0006782)4.13503722
23nuclear pore organization (GO:0006999)4.11532387
24translational elongation (GO:0006414)4.11433116
25cotranslational protein targeting to membrane (GO:0006613)4.09839168
26regulation of mitochondrial translation (GO:0070129)4.05992740
27protein targeting to ER (GO:0045047)4.04239561
28respiratory chain complex IV assembly (GO:0008535)3.95849680
29respiratory electron transport chain (GO:0022904)3.91059049
30DNA duplex unwinding (GO:0032508)3.90976857
31protein localization to endoplasmic reticulum (GO:0070972)3.83033949
32electron transport chain (GO:0022900)3.82985656
33mitotic nuclear envelope disassembly (GO:0007077)3.82794103
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.81835209
35heme biosynthetic process (GO:0006783)3.74358557
36oxidative demethylation (GO:0070989)3.73443681
37regulation of translational fidelity (GO:0006450)3.72989258
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.72610606
39protoporphyrinogen IX metabolic process (GO:0046501)3.72450213
40COPI coating of Golgi vesicle (GO:0048205)3.72065359
41Golgi transport vesicle coating (GO:0048200)3.72065359
42pore complex assembly (GO:0046931)3.71649499
43protein localization to chromosome, centromeric region (GO:0071459)3.69311130
44DNA geometric change (GO:0032392)3.69054235
45proline biosynthetic process (GO:0006561)3.68049848
46ribosomal small subunit assembly (GO:0000028)3.66608870
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.66285974
48nuclear envelope disassembly (GO:0051081)3.64975239
49membrane disassembly (GO:0030397)3.64975239
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.63742474
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.63742474
52ubiquinone biosynthetic process (GO:0006744)3.62737530
53quinone biosynthetic process (GO:1901663)3.62737530
54DNA replication checkpoint (GO:0000076)3.61769312
55negative regulation of RNA splicing (GO:0033119)3.61717902
56regulation of mammary gland epithelial cell proliferation (GO:0033599)3.57604281
57cytochrome complex assembly (GO:0017004)3.56286190
58response to misfolded protein (GO:0051788)3.55685843
59tRNA methylation (GO:0030488)3.54345055
60cellular protein complex disassembly (GO:0043624)3.53672353
61negative regulation of mRNA metabolic process (GO:1903312)3.51385953
62NADH metabolic process (GO:0006734)3.50980814
63DNA topological change (GO:0006265)3.47194168
64protein complex localization (GO:0031503)3.46306599
65mitotic metaphase plate congression (GO:0007080)3.46038871
66nuclear envelope organization (GO:0006998)3.44729164
67DNA unwinding involved in DNA replication (GO:0006268)3.44473690
68heterochromatin organization (GO:0070828)3.42947498
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.42763784
70DNA synthesis involved in DNA repair (GO:0000731)3.41638245
71maturation of SSU-rRNA (GO:0030490)3.40869438
72viral life cycle (GO:0019058)3.40606199
73regulation of mitotic spindle organization (GO:0060236)3.37653051
74mitotic sister chromatid cohesion (GO:0007064)3.34247410
75telomere maintenance via recombination (GO:0000722)3.33654084
76protein localization to kinetochore (GO:0034501)3.32960618
77DNA conformation change (GO:0071103)3.32323456
78intra-S DNA damage checkpoint (GO:0031573)3.30660816
79peptidyl-arginine omega-N-methylation (GO:0035247)3.27411959
80regulation of translational termination (GO:0006449)3.26863816
81ubiquinone metabolic process (GO:0006743)3.25317604
82aerobic respiration (GO:0009060)3.24825559
83chromosome condensation (GO:0030261)3.24504943
84pteridine-containing compound biosynthetic process (GO:0042559)3.20712992
85DNA strand elongation involved in DNA replication (GO:0006271)3.18106424
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18069619
87cellular protein complex localization (GO:0034629)3.15157100
88protein complex disassembly (GO:0043241)3.13978619
89rRNA modification (GO:0000154)3.13543674
90protein retention in ER lumen (GO:0006621)3.11951673
91viral mRNA export from host cell nucleus (GO:0046784)3.11794931
92mitotic recombination (GO:0006312)3.11023540
93formation of translation preinitiation complex (GO:0001731)3.10155559
94RNA methylation (GO:0001510)3.08715934
95regulation of spindle organization (GO:0090224)3.07484041
96telomere maintenance via semi-conservative replication (GO:0032201)3.06041294
97apoptotic process involved in morphogenesis (GO:0060561)3.06025424
98regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05072466
99translational initiation (GO:0006413)3.04691370
100ribosome assembly (GO:0042255)3.04352633
101chaperone-mediated protein transport (GO:0072321)3.02345613
102succinate metabolic process (GO:0006105)3.01540328
103macromolecular complex disassembly (GO:0032984)3.01272474
104DNA strand elongation (GO:0022616)3.01165517
105maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.01022338
106L-serine metabolic process (GO:0006563)3.01004662
107regulation of RNA export from nucleus (GO:0046831)2.98984591
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98761770
109rRNA methylation (GO:0031167)2.98486356
110folic acid metabolic process (GO:0046655)2.96484341
111snRNA metabolic process (GO:0016073)2.96354419
112protein-cofactor linkage (GO:0018065)2.95470054
113transcription from mitochondrial promoter (GO:0006390)2.94781275
114negative regulation of chromosome segregation (GO:0051985)2.94580877
115positive regulation of cell cycle checkpoint (GO:1901978)2.93868555
116porphyrin-containing compound biosynthetic process (GO:0006779)2.93783669
117heme metabolic process (GO:0042168)2.93595713
118cellular component biogenesis (GO:0044085)2.91417051
119mitochondrial DNA metabolic process (GO:0032042)2.87185293
120regulation of DNA damage checkpoint (GO:2000001)2.85796962
121GDP-mannose metabolic process (GO:0019673)2.84962896
122rRNA transcription (GO:0009303)2.84417129
123mRNA cleavage (GO:0006379)2.83167668
124positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.83059313
125mannosylation (GO:0097502)2.82832957
126regulation of chromatin binding (GO:0035561)2.82620433
127protein export from nucleus (GO:0006611)2.81971183
128chromosome segregation (GO:0007059)2.81137952
129DNA packaging (GO:0006323)2.79378646
130histone arginine methylation (GO:0034969)2.79045266
131ribosomal large subunit biogenesis (GO:0042273)2.78367360
132regulation of chromosome segregation (GO:0051983)2.77937831
133translation (GO:0006412)2.77830454
134mitotic spindle assembly checkpoint (GO:0007094)2.77744658
135regulation of sister chromatid cohesion (GO:0007063)2.77023583
136protein targeting to mitochondrion (GO:0006626)2.76196967
137tRNA modification (GO:0006400)2.76183728
138IMP biosynthetic process (GO:0006188)2.76037925
139peptidyl-lysine dimethylation (GO:0018027)2.75788703
140negative regulation of mitotic sister chromatid separation (GO:2000816)2.74807601
141negative regulation of sister chromatid segregation (GO:0033046)2.74807601
142negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74807601
143negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74807601
144negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74807601
145dosage compensation (GO:0007549)2.72036749
146positive regulation of chromosome segregation (GO:0051984)2.71754241
147spindle assembly checkpoint (GO:0071173)2.71181932
148metaphase plate congression (GO:0051310)2.70882452
149primitive streak formation (GO:0090009)2.70566212
150oxaloacetate metabolic process (GO:0006107)2.70089065
151mRNA transport (GO:0051028)2.69435771
152retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68474663
153mRNA stabilization (GO:0048255)2.68401762
154RNA stabilization (GO:0043489)2.68401762
155establishment of integrated proviral latency (GO:0075713)2.67840760
156spindle checkpoint (GO:0031577)2.67460708
157kinetochore organization (GO:0051383)2.66919891
158pseudouridine synthesis (GO:0001522)2.66876095
159mitotic spindle checkpoint (GO:0071174)2.65210109
160tetrapyrrole biosynthetic process (GO:0033014)2.65203785
1613-UTR-mediated mRNA stabilization (GO:0070935)2.64871839
162nucleobase-containing small molecule interconversion (GO:0015949)2.64777021
163metallo-sulfur cluster assembly (GO:0031163)2.64486816
164iron-sulfur cluster assembly (GO:0016226)2.64486816
165nuclear envelope reassembly (GO:0031468)2.63972239
166mitotic nuclear envelope reassembly (GO:0007084)2.63972239
167regulation of cell cycle checkpoint (GO:1901976)2.63780666
168DNA replication-dependent nucleosome assembly (GO:0006335)2.63731794
169histone H2A acetylation (GO:0043968)2.63536574
170mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.62997529
171ribonucleoprotein complex biogenesis (GO:0022613)2.62706075
172negative regulation of mRNA processing (GO:0050686)2.62612117
173pentose-phosphate shunt (GO:0006098)2.61910797
174galactose catabolic process (GO:0019388)2.61681704
175nuclear-transcribed mRNA catabolic process (GO:0000956)2.60022454
176pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58219667
177regulation of oxidative phosphorylation (GO:0002082)2.57495819
178establishment of protein localization to mitochondrion (GO:0072655)2.56943694
179acetyl-CoA metabolic process (GO:0006084)2.56925740
180neuronal action potential propagation (GO:0019227)2.56308534
181misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.56217112
182positive regulation of protein homodimerization activity (GO:0090073)2.56006476
183urogenital system development (GO:0001655)2.54885972
184tricarboxylic acid metabolic process (GO:0072350)2.54663490
185RNA modification (GO:0009451)2.54567360
186positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.54028857
187protein targeting to membrane (GO:0006612)2.53439432
188oxygen transport (GO:0015671)2.52351499
189cellular response to interleukin-15 (GO:0071350)2.52042038
190ATP biosynthetic process (GO:0006754)2.51613540
191response to pheromone (GO:0019236)10.6130453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.83845044
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.01191497
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87779239
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.69745540
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.48128815
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.32453890
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.25185254
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.16023671
9* GABP_17652178_ChIP-ChIP_JURKAT_Human3.06161009
10THAP11_20581084_ChIP-Seq_MESCs_Mouse2.97262058
11CIITA_25753668_ChIP-Seq_RAJI_Human2.76707489
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71537599
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.68469230
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.64080003
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.59353805
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54121567
17E2F7_22180533_ChIP-Seq_HELA_Human2.51404898
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.41930111
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33851309
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32694216
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.32379252
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24442152
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.22857931
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.21782890
25XRN2_22483619_ChIP-Seq_HELA_Human2.20843697
26GATA1_22025678_ChIP-Seq_K562_Human2.18907939
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18307314
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09580393
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.08245589
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.07388058
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.05677846
32EZH2_22144423_ChIP-Seq_EOC_Human1.98997881
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97792022
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95857765
35FOXP3_21729870_ChIP-Seq_TREG_Human1.93681593
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88024063
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.86400129
38CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.85612176
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85363063
40* GABP_19822575_ChIP-Seq_HepG2_Human1.80699934
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80332053
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78511139
43DCP1A_22483619_ChIP-Seq_HELA_Human1.76154581
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75507913
45VDR_23849224_ChIP-Seq_CD4+_Human1.72993546
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71632184
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70726083
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.70207927
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69648896
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69106081
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68867585
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.68300185
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.68081261
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.65249417
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64201354
56CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.62614742
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.59570871
58* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.59562408
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58150439
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51198977
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49942095
62KDM5A_27292631_Chip-Seq_BREAST_Human1.49420852
63TTF2_22483619_ChIP-Seq_HELA_Human1.48531632
64VDR_21846776_ChIP-Seq_THP-1_Human1.46248291
65* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.45460843
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44822347
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43783120
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43752888
69SCL_19346495_ChIP-Seq_HPC-7_Human1.42041538
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40330138
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39625004
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38276487
73RACK7_27058665_Chip-Seq_MCF-7_Human1.35787568
74* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34613901
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33841740
76TCF7_22412390_ChIP-Seq_EML_Mouse1.32607342
77* MYC_22102868_ChIP-Seq_BL_Human1.32048870
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32020199
79MAF_26560356_Chip-Seq_TH2_Human1.30366691
80AR_21909140_ChIP-Seq_LNCAP_Human1.30169034
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29121471
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29079731
83* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28954945
84KDM2B_26808549_Chip-Seq_DND41_Human1.28810111
85TFEB_21752829_ChIP-Seq_HELA_Human1.28793435
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27743453
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26681667
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26534820
89ZNF263_19887448_ChIP-Seq_K562_Human1.26342265
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24753119
91ELK1_22589737_ChIP-Seq_MCF10A_Human1.24435983
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24426252
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22479018
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21693096
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20306734
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20149257
97P68_20966046_ChIP-Seq_HELA_Human1.18332297
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16427312
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15746423
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15407000
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14584567
102YY1_22570637_ChIP-Seq_MALME-3M_Human1.14558763
103HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14240282
104EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13389017
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13264256
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12897587
107MAF_26560356_Chip-Seq_TH1_Human1.12315245
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10636623
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10163524
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10092719
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.09741043
112ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09438463
113NCOR1_26117541_ChIP-Seq_K562_Human1.07686552
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07527493
115UTX_26944678_Chip-Seq_JUKART_Human1.07455842
116ELF1_20517297_ChIP-Seq_JURKAT_Human1.04628291
117ZNF274_21170338_ChIP-Seq_K562_Hela1.04202585
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03704398
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02480022
120CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01363410
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01126019
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01091735
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99838195
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99651905
125SMC4_20622854_ChIP-Seq_HELA_Human0.98827525
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98398779
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96649937
128POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94624326
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94331190
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94189065
131FOXP1_21924763_ChIP-Seq_HESCs_Human0.93815676
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92643337
133SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92187530
134* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89035377
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88715685
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88309078
137LXR_22292898_ChIP-Seq_THP-1_Human0.87863025
138PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84993711
139MYC_18940864_ChIP-ChIP_HL60_Human0.84847806
140* CTCF_26484167_Chip-Seq_Bcells_Mouse0.84683606
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84501656
142TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84235774
143LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84113055
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83884263
145BCL6_27268052_Chip-Seq_Bcells_Human0.82259611
146NOTCH1_21737748_ChIP-Seq_TLL_Human0.81413196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology4.64215919
2MP0003880_abnormal_central_pattern3.87180455
3MP0008057_abnormal_DNA_replication3.59943927
4MP0003077_abnormal_cell_cycle3.53589221
5MP0004147_increased_porphyrin_level3.33879851
6MP0009379_abnormal_foot_pigmentation3.13472051
7MP0008260_abnormal_autophagy3.11144311
8MP0004957_abnormal_blastocyst_morpholog3.08228359
9MP0006292_abnormal_olfactory_placode2.76316418
10MP0002638_abnormal_pupillary_reflex2.74349269
11MP0005451_abnormal_body_composition2.66218138
12MP0003705_abnormal_hypodermis_morpholog2.65905715
13MP0008932_abnormal_embryonic_tissue2.59725267
14MP0006035_abnormal_mitochondrial_morpho2.58113164
15MP0001730_embryonic_growth_arrest2.48608850
16MP0002396_abnormal_hematopoietic_system2.41776857
17MP0006276_abnormal_autonomic_nervous2.41006688
18MP0006036_abnormal_mitochondrial_physio2.38633167
19MP0008058_abnormal_DNA_repair2.30128711
20MP0005076_abnormal_cell_differentiation2.29232579
21MP0004859_abnormal_synaptic_plasticity2.29128493
22MP0005646_abnormal_pituitary_gland2.28909100
23MP0005058_abnormal_lysosome_morphology2.23996262
24MP0003806_abnormal_nucleotide_metabolis2.19418376
25MP0000350_abnormal_cell_proliferation2.13800159
26MP0005171_absent_coat_pigmentation2.10319787
27MP0002089_abnormal_postnatal_growth/wei2.05199998
28MP0003122_maternal_imprinting1.97995705
29MP0004233_abnormal_muscle_weight1.93920470
30MP0002877_abnormal_melanocyte_morpholog1.88189628
31MP0005380_embryogenesis_phenotype1.85346970
32MP0001672_abnormal_embryogenesis/_devel1.85346970
33MP0008569_lethality_at_weaning1.85258967
34MP0001849_ear_inflammation1.80192887
35MP0002080_prenatal_lethality1.75264946
36MP0003984_embryonic_growth_retardation1.72323742
37MP0002234_abnormal_pharynx_morphology1.71455506
38MP0003763_abnormal_thymus_physiology1.65392053
39MP0000313_abnormal_cell_death1.65176287
40MP0009278_abnormal_bone_marrow1.64726269
41MP0001529_abnormal_vocalization1.64103468
42MP0002822_catalepsy1.62916068
43MP0010030_abnormal_orbit_morphology1.61923474
44MP0002088_abnormal_embryonic_growth/wei1.61774468
45MP0009672_abnormal_birth_weight1.57707904
46MP0009697_abnormal_copulation1.57292130
47MP0008961_abnormal_basal_metabolism1.56442987
48MP0001697_abnormal_embryo_size1.53386183
49MP0003183_abnormal_peptide_metabolism1.52548749
50MP0004142_abnormal_muscle_tone1.51256862
51MP0000751_myopathy1.50321328
52MP0003011_delayed_dark_adaptation1.49892766
53MP0001188_hyperpigmentation1.49052051
54MP0003786_premature_aging1.48808755
55MP0005174_abnormal_tail_pigmentation1.47326233
56MP0001764_abnormal_homeostasis1.45352460
57MP0003635_abnormal_synaptic_transmissio1.44889716
58MP0005621_abnormal_cell_physiology1.43094391
59MP0010307_abnormal_tumor_latency1.42735808
60MP0002064_seizures1.37366692
61MP0004185_abnormal_adipocyte_glucose1.36639977
62MP0003221_abnormal_cardiomyocyte_apopto1.35359198
63MP0003693_abnormal_embryo_hatching1.34262464
64MP0004215_abnormal_myocardial_fiber1.34145459
65MP0000631_abnormal_neuroendocrine_gland1.32642151
66MP0000015_abnormal_ear_pigmentation1.32389073
67MP0005075_abnormal_melanosome_morpholog1.32266349
68MP0002086_abnormal_extraembryonic_tissu1.31256559
69MP0002085_abnormal_embryonic_tissue1.29108568
70MP0005384_cellular_phenotype1.28416820
71MP0005551_abnormal_eye_electrophysiolog1.26747808
72MP0002837_dystrophic_cardiac_calcinosis1.26221252
73MP0003453_abnormal_keratinocyte_physiol1.25663817
74MP0001986_abnormal_taste_sensitivity1.24316561
75MP0002272_abnormal_nervous_system1.24310543
76MP0000372_irregular_coat_pigmentation1.23250636
77MP0009333_abnormal_splenocyte_physiolog1.20743423
78MP0003646_muscle_fatigue1.20341306
79MP0002163_abnormal_gland_morphology1.20276537
80MP0000678_abnormal_parathyroid_gland1.19815618
81MP0003566_abnormal_cell_adhesion1.19125030
82MP0004808_abnormal_hematopoietic_stem1.18129800
83MP0001502_abnormal_circadian_rhythm1.17729027
84MP0002084_abnormal_developmental_patter1.16000389
85MP0001984_abnormal_olfaction1.15970347
86MP0003329_amyloid_beta_deposits1.14817287
87MP0000358_abnormal_cell_content/1.14805909
88MP0004197_abnormal_fetal_growth/weight/1.14691530
89MP0009046_muscle_twitch1.14546907
90MP0005501_abnormal_skin_physiology1.14368091
91MP0002019_abnormal_tumor_incidence1.14294203
92MP0005645_abnormal_hypothalamus_physiol1.13695911
93MP0002095_abnormal_skin_pigmentation1.12817490
94MP0004381_abnormal_hair_follicle1.12645269
95MP0003959_abnormal_lean_body1.11105766
96MP0000703_abnormal_thymus_morphology1.10404305
97MP0000003_abnormal_adipose_tissue1.09877635
98MP0003136_yellow_coat_color1.07891630
99MP0002067_abnormal_sensory_capabilities1.07672152
100MP0001853_heart_inflammation1.07082809
101MP0010329_abnormal_lipoprotein_level1.07074839
102MP0002249_abnormal_larynx_morphology1.05660927
103MP0005409_darkened_coat_color1.05508971
104MP0005266_abnormal_metabolism1.05425430
105MP0002557_abnormal_social/conspecific_i1.05143599
106MP0005623_abnormal_meninges_morphology1.04845992
107MP0006054_spinal_hemorrhage1.04286027
108MP0000778_abnormal_nervous_system1.04248970
109MP0002938_white_spotting1.03909351
110MP0003123_paternal_imprinting1.03882024
111MP0001348_abnormal_lacrimal_gland1.03687895
112MP0000747_muscle_weakness1.02408755
113MP0005365_abnormal_bile_salt1.02163786
114MP0005671_abnormal_response_to1.02053197
115MP0004858_abnormal_nervous_system1.02045825
116MP0003656_abnormal_erythrocyte_physiolo1.01819747
117MP0005220_abnormal_exocrine_pancreas1.01647759
118MP0002736_abnormal_nociception_after1.00076096
119MP0005083_abnormal_biliary_tract0.99227201
120MP0002063_abnormal_learning/memory/cond0.98092327
121MP0009745_abnormal_behavioral_response0.97954512
122MP0000733_abnormal_muscle_development0.96521074
123MP0002090_abnormal_vision0.96342593
124MP0000537_abnormal_urethra_morphology0.96226779
125MP0003121_genomic_imprinting0.95016528
126MP0004084_abnormal_cardiac_muscle0.94207347
127MP0001915_intracranial_hemorrhage0.94109281
128MP0001440_abnormal_grooming_behavior0.93701891
129MP0010352_gastrointestinal_tract_polyps0.93338597
130MP0005253_abnormal_eye_physiology0.92146765
131MP0004133_heterotaxia0.91056141
132MP0002139_abnormal_hepatobiliary_system0.90550765
133MP0010630_abnormal_cardiac_muscle0.90054690
134MP0010094_abnormal_chromosome_stability0.89900366
135MP0002572_abnormal_emotion/affect_behav0.89869302
136MP0003868_abnormal_feces_composition0.88099519
137MP0003879_abnormal_hair_cell0.87447761
138MP0002398_abnormal_bone_marrow0.87397679
139MP0008007_abnormal_cellular_replicative0.87186134
140MP0001661_extended_life_span0.86219379
141MP0000858_altered_metastatic_potential0.85900342
142MP0003172_abnormal_lysosome_physiology0.85517032
143MP0001346_abnormal_lacrimal_gland0.85516088
144MP0002078_abnormal_glucose_homeostasis0.85377859
145MP0003943_abnormal_hepatobiliary_system0.85215638
146MP0003137_abnormal_impulse_conducting0.84399957
147MP0005332_abnormal_amino_acid0.84224702
148MP0005379_endocrine/exocrine_gland_phen0.83815247
149MP0003091_abnormal_cell_migration0.83619900
150MP0005636_abnormal_mineral_homeostasis0.83064368
151MP0000685_abnormal_immune_system0.82548601
152MP0005666_abnormal_adipose_tissue0.81246245
153MP0002269_muscular_atrophy0.80256552
154MP0000049_abnormal_middle_ear0.79618810
155MP0008872_abnormal_physiological_respon0.79316285
156MP0002075_abnormal_coat/hair_pigmentati0.79051685
157MP0000759_abnormal_skeletal_muscle0.77400416
158MP0006072_abnormal_retinal_apoptosis0.77386895
159MP0002697_abnormal_eye_size0.76698024
160MP0005670_abnormal_white_adipose0.75864927
161MP0003866_abnormal_defecation0.75792545
162MP0005584_abnormal_enzyme/coenzyme_acti0.74778004
163MP0002970_abnormal_white_adipose0.73941239
164MP0005423_abnormal_somatic_nervous0.73875322
165MP0005375_adipose_tissue_phenotype0.73853551
166MP0002060_abnormal_skin_morphology0.73741874
167MP0005330_cardiomyopathy0.73633271
168MP0004087_abnormal_muscle_fiber0.73492221
169MP0001905_abnormal_dopamine_level0.72772950
170MP0003115_abnormal_respiratory_system0.72708872
171MP0000490_abnormal_crypts_of0.72615979
172MP0002111_abnormal_tail_morphology0.71426093
173MP0002722_abnormal_immune_system0.70821245
174MP0002092_abnormal_eye_morphology0.70355166
175MP0004264_abnormal_extraembryonic_tissu0.67385709
176MP0002429_abnormal_blood_cell0.62977434
177MP0000371_diluted_coat_color0.62392262
178MP0000750_abnormal_muscle_regeneration0.60912853
179MP0009703_decreased_birth_body0.60773568
180MP0009931_abnormal_skin_appearance0.60630031
181MP0001243_abnormal_dermal_layer0.59517605

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.87222340
2Hepatocellular necrosis (HP:0001404)4.76398961
3Abnormal mitochondria in muscle tissue (HP:0008316)4.67370974
4Mitochondrial inheritance (HP:0001427)4.42078340
5Acute encephalopathy (HP:0006846)4.41195734
6Hepatic necrosis (HP:0002605)4.29148924
7Abnormality of the heme biosynthetic pathway (HP:0010472)4.23991922
8Increased CSF lactate (HP:0002490)4.02241149
9Conjugated hyperbilirubinemia (HP:0002908)3.93225556
10Progressive macrocephaly (HP:0004481)3.92011278
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.69824900
12Progressive muscle weakness (HP:0003323)3.39347269
13Abnormality of cells of the erythroid lineage (HP:0012130)3.36980011
14Chromsome breakage (HP:0040012)3.31387818
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.29204760
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.29204760
17Cerebral edema (HP:0002181)3.28673713
18Ulnar bowing (HP:0003031)3.27592260
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.24519721
20Reduced antithrombin III activity (HP:0001976)3.20296176
21Poor suck (HP:0002033)3.17507613
22* Lactic acidosis (HP:0003128)3.16720284
23Abnormal number of erythroid precursors (HP:0012131)3.11447973
24* Increased serum lactate (HP:0002151)3.02354426
25Exercise intolerance (HP:0003546)3.02083336
26Broad distal phalanx of finger (HP:0009836)3.00043459
27Increased hepatocellular lipid droplets (HP:0006565)2.96128378
28Multiple enchondromatosis (HP:0005701)2.94473902
29Optic disc pallor (HP:0000543)2.93175726
30Lipid accumulation in hepatocytes (HP:0006561)2.93092496
31Hyperacusis (HP:0010780)2.92304437
32Type I transferrin isoform profile (HP:0003642)2.90480925
33Cholecystitis (HP:0001082)2.89603159
34Abnormal gallbladder physiology (HP:0012438)2.89603159
35Poikiloderma (HP:0001029)2.87227561
36Selective tooth agenesis (HP:0001592)2.73208760
37Abnormality of glycolysis (HP:0004366)2.72492737
38Increased serum pyruvate (HP:0003542)2.72492737
39Increased intramyocellular lipid droplets (HP:0012240)2.68234808
40Respiratory failure (HP:0002878)2.67576632
41Lissencephaly (HP:0001339)2.66238401
42Hypoplasia of the pons (HP:0012110)2.65168958
43Upper limb amyotrophy (HP:0009129)2.65168360
44Distal upper limb amyotrophy (HP:0007149)2.65168360
45Abnormality of alanine metabolism (HP:0010916)2.64945873
46Hyperalaninemia (HP:0003348)2.64945873
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.64945873
48Birth length less than 3rd percentile (HP:0003561)2.63376972
49Emotional lability (HP:0000712)2.62849676
50Petechiae (HP:0000967)2.59214542
51Progressive external ophthalmoplegia (HP:0000590)2.56693274
52Increased muscle lipid content (HP:0009058)2.56128214
53Esotropia (HP:0000565)2.49045640
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.48790475
553-Methylglutaconic aciduria (HP:0003535)2.48529791
56Elevated erythrocyte sedimentation rate (HP:0003565)2.45175171
57Polyphagia (HP:0002591)2.42121348
58* Hyperbilirubinemia (HP:0002904)2.41968513
59Pallor (HP:0000980)2.41930480
60Proximal placement of thumb (HP:0009623)2.35317279
61Abnormality of the pons (HP:0007361)2.33773833
62Long palpebral fissure (HP:0000637)2.32569179
63Breast hypoplasia (HP:0003187)2.31412756
64Neuroendocrine neoplasm (HP:0100634)2.29889497
65Absent radius (HP:0003974)2.28509882
66Supranuclear gaze palsy (HP:0000605)2.27255101
67Abnormal protein glycosylation (HP:0012346)2.26224762
68Abnormal glycosylation (HP:0012345)2.26224762
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26224762
70Abnormal protein N-linked glycosylation (HP:0012347)2.26224762
71Squamous cell carcinoma (HP:0002860)2.25860818
72Deviation of the thumb (HP:0009603)2.24863977
73Type II lissencephaly (HP:0007260)2.24709462
74Renal Fanconi syndrome (HP:0001994)2.24386929
75Distal lower limb amyotrophy (HP:0008944)2.24327116
76Type 2 muscle fiber atrophy (HP:0003554)2.23675145
77Nephrogenic diabetes insipidus (HP:0009806)2.23102092
78Hand muscle atrophy (HP:0009130)2.22331431
79Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21407697
80Deep palmar crease (HP:0006191)2.21000290
81Gliosis (HP:0002171)2.19338502
82CNS demyelination (HP:0007305)2.19284649
83High anterior hairline (HP:0009890)2.16882707
84Aplastic anemia (HP:0001915)2.16871916
85Severe visual impairment (HP:0001141)2.15852962
86Macrocytic anemia (HP:0001972)2.15219029
87Cortical visual impairment (HP:0100704)2.13770521
88Increased nuchal translucency (HP:0010880)2.13601113
89Broad face (HP:0000283)2.11496320
90Metaphyseal cupping (HP:0003021)2.11468382
91Prominent nose (HP:0000448)2.10864050
92Central scotoma (HP:0000603)2.09914908
93Abnormality of the calcaneus (HP:0008364)2.09567541
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08423835
95Opisthotonus (HP:0002179)2.07930720
96Leukodystrophy (HP:0002415)2.07601096
97Dicarboxylic aciduria (HP:0003215)2.07409106
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07409106
99Respiratory difficulties (HP:0002880)2.07379883
100Testicular atrophy (HP:0000029)2.05778204
101Biconcave vertebral bodies (HP:0004586)2.05439265
102Aplasia involving forearm bones (HP:0009822)2.03627874
103Absent forearm bone (HP:0003953)2.03627874
104Centrally nucleated skeletal muscle fibers (HP:0003687)2.02963520
105Pointed chin (HP:0000307)2.02083356
106Hypoproteinemia (HP:0003075)2.01943233
107Upper motor neuron abnormality (HP:0002127)2.00918341
108Oral leukoplakia (HP:0002745)1.99396619
109Trismus (HP:0000211)1.98914699
110Akinesia (HP:0002304)1.98863730
111Spastic paraparesis (HP:0002313)1.98626542
112Achilles tendon contracture (HP:0001771)1.97301267
113Flared metaphyses (HP:0003015)1.97237226
114Abnormality of the fingertips (HP:0001211)1.97052379
115Intestinal fistula (HP:0100819)1.95446236
116Increased connective tissue (HP:0009025)1.94863949
117Hypsarrhythmia (HP:0002521)1.91632730
118Purpura (HP:0000979)1.91473950
119Unsteady gait (HP:0002317)1.89886907
120Thin ribs (HP:0000883)1.89840052
121Fetal akinesia sequence (HP:0001989)1.89001868
122Lethargy (HP:0001254)1.88641488
123Neoplasm of the peripheral nervous system (HP:0100007)1.88236236
124Muscle fiber atrophy (HP:0100295)1.87549900
125External ophthalmoplegia (HP:0000544)1.87427483
126Self-mutilation (HP:0000742)1.86930921
127Late onset (HP:0003584)1.86524395
128Abnormality of cochlea (HP:0000375)1.85525117
129Nonimmune hydrops fetalis (HP:0001790)1.84909371
130Retinal dysplasia (HP:0007973)1.84605964
131Sparse lateral eyebrow (HP:0005338)1.84161570
132* Microvesicular hepatic steatosis (HP:0001414)1.83726554
133Hypobetalipoproteinemia (HP:0003563)1.83578165
134Microretrognathia (HP:0000308)1.82944941
135Abnormality of the umbilical cord (HP:0010881)1.82788099
136Vertebral compression fractures (HP:0002953)1.82774466
137Vaginal fistula (HP:0004320)1.82770922
138Ragged-red muscle fibers (HP:0003200)1.82626349
139Long eyelashes (HP:0000527)1.82041231
140Methylmalonic aciduria (HP:0012120)1.81611587
141Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81170824
142EEG with generalized epileptiform discharges (HP:0011198)1.79486307
143Prolonged bleeding time (HP:0003010)1.79123855
144Facial hemangioma (HP:0000329)1.78463205
145Hyperglycinuria (HP:0003108)1.78000020
146Entropion (HP:0000621)1.77731968
147Cerebral aneurysm (HP:0004944)1.76979013
148Focal motor seizures (HP:0011153)1.76816721
149Pancytopenia (HP:0001876)1.76535199
150Myopathic facies (HP:0002058)1.76534511
151Urethral obstruction (HP:0000796)1.76520639
152Premature skin wrinkling (HP:0100678)1.76291646
153Pseudobulbar signs (HP:0002200)1.76233095
154Epileptic encephalopathy (HP:0200134)1.76123940
155Insomnia (HP:0100785)1.75899001
156Epileptiform EEG discharges (HP:0011182)1.75110831
157Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74270645
158Cafe-au-lait spot (HP:0000957)1.73658712
159Abnormality of the thoracic spine (HP:0100711)1.72626513
160Gastrointestinal stroma tumor (HP:0100723)1.72251811
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71753185
162Absent epiphyses (HP:0010577)1.71753185
163Abnormality of the preputium (HP:0100587)1.71424622
164Glossoptosis (HP:0000162)1.71018533
165Hypoglycemic coma (HP:0001325)1.70918684
166Ketosis (HP:0001946)1.70645381
167Colitis (HP:0002583)1.70542333
168Rough bone trabeculation (HP:0100670)1.70503929
169Acute lymphatic leukemia (HP:0006721)1.70483989
170Dislocated radial head (HP:0003083)1.68155696
171Cholelithiasis (HP:0001081)1.68153819
172Disproportionate tall stature (HP:0001519)1.68051716
173Ureteral duplication (HP:0000073)1.68048224
174Nuclear cataract (HP:0100018)1.66899476
175Basal cell carcinoma (HP:0002671)1.66359364
176Trigonocephaly (HP:0000243)1.66043074
177Dysmetric saccades (HP:0000641)1.65549357
178Preauricular skin tag (HP:0000384)1.64429680
179Atresia of the external auditory canal (HP:0000413)1.64060038
180Lower limb amyotrophy (HP:0007210)1.64038084
181Flattened epiphyses (HP:0003071)1.62184565
182Impaired proprioception (HP:0010831)1.61341645
183Optic nerve coloboma (HP:0000588)1.61098449
184Gastrointestinal dysmotility (HP:0002579)1.59944463
185Abnormality of the distal phalanx of the thumb (HP:0009617)1.58787525
186Overlapping toe (HP:0001845)1.57906416
187Horseshoe kidney (HP:0000085)1.57608602
188Premature ovarian failure (HP:0008209)1.57377086
189Abnormality of the lower motor neuron (HP:0002366)1.56672888
190Duplication of thumb phalanx (HP:0009942)1.56100123
191Premature graying of hair (HP:0002216)1.55445413
192Dysautonomia (HP:0002459)1.55345555
193Abnormality of the Achilles tendon (HP:0005109)1.55159410
194Distal sensory impairment (HP:0002936)1.54626851
195Hypopigmentation of the fundus (HP:0007894)1.54121784
196Ankyloglossia (HP:0010296)1.53371731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.90021148
2TRIB34.30613280
3SMG13.60646614
4CDK123.42856117
5MAP3K102.77865308
6SRPK12.73251466
7ICK2.61993670
8MAP3K122.52632119
9STK162.47701519
10CDC72.31321359
11MAP3K112.27121070
12PRPF4B2.26608019
13EEF2K2.24190158
14MAP3K132.20481068
15VRK12.15890889
16BUB11.97597358
17IRAK31.96468104
18KIT1.94222730
19PDK21.93022063
20ARAF1.88406462
21PKN21.85429102
22BCKDK1.84759018
23CDK81.84221996
24PBK1.81581070
25MAPK131.81509935
26NTRK21.79901269
27TTK1.76540255
28ERN11.72942424
29DYRK31.67790249
30NME21.63371829
31CDK41.62834217
32MUSK1.53402548
33TEC1.53035046
34CDK191.51130249
35GRK61.49246191
36WEE11.45671394
37PIM21.44885078
38SIK11.43105027
39TESK21.42812547
40SIK21.34650101
41NEK21.33702029
42TGFBR11.27457847
43TTN1.26087478
44MAP2K31.25546019
45BRAF1.24987072
46CHEK11.23710757
47EIF2AK11.22755861
48MTOR1.19003716
49MST1R1.18770782
50PLK11.18498573
51MAPK111.18437020
52MAP3K81.15326766
53CDK61.14800770
54BRD41.14494896
55NME11.11812108
56WNK31.11754796
57PAK41.11018510
58TYK21.07788714
59PDK41.07424730
60PDK31.07424730
61MAP2K71.06015298
62MAP4K11.05454555
63PASK1.02365477
64FGFR41.01713661
65SYK1.01146056
66EIF2AK30.99386751
67BMX0.98003847
68CAMK10.95605297
69KDR0.95321730
70FES0.93379433
71AURKB0.92325931
72INSRR0.90105713
73SIK30.89847872
74TLK10.89374823
75UHMK10.86622178
76CAMK1D0.86590891
77TXK0.86258397
78MAPK40.85520141
79MELK0.85447887
80NEK10.84969122
81LMTK20.83109189
82PDGFRA0.83097033
83STK40.81668994
84RAF10.79462976
85MARK10.75975180
86TAOK20.75695019
87WNK40.75559752
88PIK3CA0.75445119
89CDK20.75244845
90LYN0.72442692
91CDK70.71256808
92MARK30.71218678
93TSSK60.70613523
94BRSK10.70321886
95MAP2K60.68419059
96CDK90.68409439
97CDK10.67360258
98STK100.67318740
99MYLK0.66263163
100PLK40.63033022
101BLK0.62800696
102BTK0.61902673
103YES10.61640816
104CCNB10.61531190
105KSR10.60853403
106PRKCI0.60634721
107MKNK10.59745916
108PIM10.59316835
109MAP3K140.58982681
110RIPK10.58051755
111PRKG20.57239229
112PRKCH0.57057299
113TIE10.57039475
114RPS6KC10.56365833
115RPS6KL10.56365833
116RPS6KB20.56042904
117CDC42BPA0.55923246
118CSNK1G10.55446296
119CSNK2A20.54532797
120AKT20.53941300
121ATR0.53928904
122PAK10.53632945
123EPHB20.52395464
124ZAP700.52235026
125AURKA0.51171852
126CDK50.50681159
127CAMK1G0.50658894
128ATM0.50467260
129MAP2K40.49692664
130TESK10.49481751
131IRAK20.49404756
132CAMKK20.48571382
133ZAK0.47459221
134CDK11A0.45934043
135MATK0.44699022
136ALK0.44691473
137PHKG20.44445738
138PHKG10.44445738
139DAPK10.44115132
140CASK0.43878622
141CHEK20.43792576
142JAK30.43514009
143SCYL20.42989315
144VRK20.42686948
145PDPK10.42081562
146ERBB20.41748704
147PRKD30.41437458
148MAPK120.40926444
149KSR20.40631265
150LATS20.40085953
151PRKACA0.39978948
152CDK150.39109963
153DYRK20.38947431
154PRKD20.37934256
155CDK180.37544614
156RPS6KA10.35163396
157RPS6KA60.35033276
158TGFBR20.34990833
159NTRK30.34869755
160MAP3K70.34607786
161ERBB40.34422703
162MET0.33912971
163DYRK1B0.33823518
164CSNK1G30.33300665
165MARK20.33182808
166DYRK1A0.32932310
167PRKCG0.31365934
168MAP3K10.31027264

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.07005205
2Oxidative phosphorylation_Homo sapiens_hsa001903.35666147
3DNA replication_Homo sapiens_hsa030303.04733306
4Parkinsons disease_Homo sapiens_hsa050122.99129579
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.70534563
6Protein export_Homo sapiens_hsa030602.54665728
7Mismatch repair_Homo sapiens_hsa034302.51169401
8* Sulfur relay system_Homo sapiens_hsa041222.49735391
9Cell cycle_Homo sapiens_hsa041102.48314374
10Proteasome_Homo sapiens_hsa030502.47688338
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32552029
12Non-homologous end-joining_Homo sapiens_hsa034502.14749515
13Spliceosome_Homo sapiens_hsa030402.13373157
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11698569
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.10983407
16Folate biosynthesis_Homo sapiens_hsa007902.09137476
17Pyrimidine metabolism_Homo sapiens_hsa002402.09132885
18RNA polymerase_Homo sapiens_hsa030202.04095124
19Alzheimers disease_Homo sapiens_hsa050102.02957845
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02597660
21Huntingtons disease_Homo sapiens_hsa050161.88548614
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77041082
23mRNA surveillance pathway_Homo sapiens_hsa030151.77031257
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75746472
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.70151804
26Lysine degradation_Homo sapiens_hsa003101.66605317
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65436840
28Propanoate metabolism_Homo sapiens_hsa006401.61137348
29Pyruvate metabolism_Homo sapiens_hsa006201.60289255
30Cardiac muscle contraction_Homo sapiens_hsa042601.60207955
31Sulfur metabolism_Homo sapiens_hsa009201.60119504
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.58050399
33Base excision repair_Homo sapiens_hsa034101.56730594
34Chronic myeloid leukemia_Homo sapiens_hsa052201.48965468
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48839184
36One carbon pool by folate_Homo sapiens_hsa006701.41686787
37Carbon metabolism_Homo sapiens_hsa012001.39964169
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.39289871
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36176845
40Acute myeloid leukemia_Homo sapiens_hsa052211.29889215
41Non-small cell lung cancer_Homo sapiens_hsa052231.28298893
42Peroxisome_Homo sapiens_hsa041461.27906636
43Fatty acid degradation_Homo sapiens_hsa000711.27861175
44Butanoate metabolism_Homo sapiens_hsa006501.26939457
45Pentose phosphate pathway_Homo sapiens_hsa000301.25582375
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23681598
47Bladder cancer_Homo sapiens_hsa052191.23433775
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21368335
49N-Glycan biosynthesis_Homo sapiens_hsa005101.18352851
50Fatty acid metabolism_Homo sapiens_hsa012121.18221778
51Biosynthesis of amino acids_Homo sapiens_hsa012301.17499786
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17039528
53Pancreatic cancer_Homo sapiens_hsa052121.13993641
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.12173783
55Fatty acid elongation_Homo sapiens_hsa000621.12063757
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10360797
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09680472
58Purine metabolism_Homo sapiens_hsa002301.09625419
59Viral carcinogenesis_Homo sapiens_hsa052031.08513659
60Epstein-Barr virus infection_Homo sapiens_hsa051691.05439736
61Small cell lung cancer_Homo sapiens_hsa052221.04061753
62Notch signaling pathway_Homo sapiens_hsa043301.01383663
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.01354455
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01115874
65Colorectal cancer_Homo sapiens_hsa052101.01048668
66Apoptosis_Homo sapiens_hsa042100.98864956
67p53 signaling pathway_Homo sapiens_hsa041150.96422411
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96069348
69Thyroid cancer_Homo sapiens_hsa052160.93270518
70HTLV-I infection_Homo sapiens_hsa051660.89156601
71Metabolic pathways_Homo sapiens_hsa011000.88516757
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.88440665
73mTOR signaling pathway_Homo sapiens_hsa041500.86687253
74Hepatitis B_Homo sapiens_hsa051610.85319981
75Nicotine addiction_Homo sapiens_hsa050330.83798588
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83585684
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83354991
78Primary immunodeficiency_Homo sapiens_hsa053400.82651965
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81852507
80Endometrial cancer_Homo sapiens_hsa052130.80776661
81MicroRNAs in cancer_Homo sapiens_hsa052060.80575296
82Insulin secretion_Homo sapiens_hsa049110.80565678
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78693336
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78526582
85Oocyte meiosis_Homo sapiens_hsa041140.78498309
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77541287
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77068857
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.77032804
89RNA degradation_Homo sapiens_hsa030180.75628408
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74517641
91Herpes simplex infection_Homo sapiens_hsa051680.74002842
92Nucleotide excision repair_Homo sapiens_hsa034200.73834101
93VEGF signaling pathway_Homo sapiens_hsa043700.72296792
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70929191
95Prostate cancer_Homo sapiens_hsa052150.70468973
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.70071255
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69519243
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69116367
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67377680
100Glioma_Homo sapiens_hsa052140.65321479
101Vitamin B6 metabolism_Homo sapiens_hsa007500.63848611
102Shigellosis_Homo sapiens_hsa051310.62023871
103Inositol phosphate metabolism_Homo sapiens_hsa005620.61578562
104Galactose metabolism_Homo sapiens_hsa000520.60771775
105GABAergic synapse_Homo sapiens_hsa047270.60443787
106Systemic lupus erythematosus_Homo sapiens_hsa053220.60423057
107Insulin signaling pathway_Homo sapiens_hsa049100.60346307
108Homologous recombination_Homo sapiens_hsa034400.58694924
109Selenocompound metabolism_Homo sapiens_hsa004500.58357750
110B cell receptor signaling pathway_Homo sapiens_hsa046620.58090396
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.56760351
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56341536
113AMPK signaling pathway_Homo sapiens_hsa041520.55665091
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54479476
115Alcoholism_Homo sapiens_hsa050340.53568296
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51851441
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51564390
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49211182
119Morphine addiction_Homo sapiens_hsa050320.47742871
120Synaptic vesicle cycle_Homo sapiens_hsa047210.46377760
121HIF-1 signaling pathway_Homo sapiens_hsa040660.46069507
122Glucagon signaling pathway_Homo sapiens_hsa049220.45551421
123Adherens junction_Homo sapiens_hsa045200.45185725
124beta-Alanine metabolism_Homo sapiens_hsa004100.43554555
125Circadian entrainment_Homo sapiens_hsa047130.43350523
126Nitrogen metabolism_Homo sapiens_hsa009100.43281809
127Tyrosine metabolism_Homo sapiens_hsa003500.43119001
128Lysosome_Homo sapiens_hsa041420.43032235
129ErbB signaling pathway_Homo sapiens_hsa040120.41810723
130Other glycan degradation_Homo sapiens_hsa005110.40281790
131Proteoglycans in cancer_Homo sapiens_hsa052050.37643014
132Hippo signaling pathway_Homo sapiens_hsa043900.34870959
133Starch and sucrose metabolism_Homo sapiens_hsa005000.34868911
134Arginine and proline metabolism_Homo sapiens_hsa003300.34752306
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34300930
136Arginine biosynthesis_Homo sapiens_hsa002200.33081259
137Phenylalanine metabolism_Homo sapiens_hsa003600.32862986
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32323754
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.32245572
140Hepatitis C_Homo sapiens_hsa051600.32103022
141Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30924249
142Choline metabolism in cancer_Homo sapiens_hsa052310.30598615
143Basal cell carcinoma_Homo sapiens_hsa052170.30384316
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28021292
145PPAR signaling pathway_Homo sapiens_hsa033200.27401495
146ABC transporters_Homo sapiens_hsa020100.25811664
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24970333
148Fructose and mannose metabolism_Homo sapiens_hsa000510.24922882
149Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24465681
150Hematopoietic cell lineage_Homo sapiens_hsa046400.22507646
151Vibrio cholerae infection_Homo sapiens_hsa051100.22437214
152Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21753071
153RNA transport_Homo sapiens_hsa030130.20318983
154Sphingolipid metabolism_Homo sapiens_hsa006000.19769562
155Calcium signaling pathway_Homo sapiens_hsa040200.14394848
156Phototransduction_Homo sapiens_hsa047440.13341926
157Glutamatergic synapse_Homo sapiens_hsa047240.12660037
158Fanconi anemia pathway_Homo sapiens_hsa034600.10832658
159Cyanoamino acid metabolism_Homo sapiens_hsa004600.09594685
160Gap junction_Homo sapiens_hsa045400.09043882

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