TRNP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.99460155
2synaptic vesicle maturation (GO:0016188)5.95777129
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.79322789
4synaptic vesicle exocytosis (GO:0016079)5.28253681
5locomotory exploration behavior (GO:0035641)5.16448369
6glutamate secretion (GO:0014047)5.12975121
7neuronal action potential propagation (GO:0019227)5.12360984
8skin morphogenesis (GO:0043589)4.95744055
9regulation of synaptic vesicle exocytosis (GO:2000300)4.93100866
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.85276024
11protein localization to synapse (GO:0035418)4.52070759
12vocalization behavior (GO:0071625)4.51501068
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.50612495
14regulation of synaptic vesicle transport (GO:1902803)4.38498200
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.36255163
16regulation of synapse structural plasticity (GO:0051823)4.33923578
17cellular potassium ion homeostasis (GO:0030007)4.32965065
18neurotransmitter secretion (GO:0007269)4.27117122
19hemidesmosome assembly (GO:0031581)4.24071145
20cell adhesion mediated by integrin (GO:0033627)4.17858142
21layer formation in cerebral cortex (GO:0021819)4.12771964
22regulation of neuronal synaptic plasticity (GO:0048168)4.11298572
23sodium ion export (GO:0071436)4.05667348
24regulation of glutamate receptor signaling pathway (GO:1900449)4.05421383
25proline transport (GO:0015824)3.99974092
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.97412128
27protein heterotrimerization (GO:0070208)3.96361423
28exploration behavior (GO:0035640)3.93739944
29regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.89598376
30regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.86879793
31protein retention in ER lumen (GO:0006621)3.86538031
32endodermal cell differentiation (GO:0035987)3.84887526
33endothelial cell morphogenesis (GO:0001886)3.82623249
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82122503
35chondrocyte proliferation (GO:0035988)3.82062756
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.81746394
37neuron cell-cell adhesion (GO:0007158)3.77236373
38prepulse inhibition (GO:0060134)3.76015513
39endocardial cushion development (GO:0003197)3.74291327
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.74131478
41cell-substrate junction assembly (GO:0007044)3.73000600
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.71843410
43activation of protein kinase A activity (GO:0034199)3.69955098
44membrane depolarization during action potential (GO:0086010)3.68455492
45positive regulation of synaptic transmission, GABAergic (GO:0032230)3.67544811
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.65938982
47negative regulation of dendrite morphogenesis (GO:0050774)3.65566452
48regulation of plasminogen activation (GO:0010755)3.64504818
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.61389552
50gamma-aminobutyric acid transport (GO:0015812)3.61235516
51desmosome organization (GO:0002934)3.59258480
52synaptic transmission, glutamatergic (GO:0035249)3.57902513
53cerebellar Purkinje cell differentiation (GO:0021702)3.56670503
54cell migration in hindbrain (GO:0021535)3.55920493
55neuron-neuron synaptic transmission (GO:0007270)3.53749754
56Golgi transport vesicle coating (GO:0048200)3.49867935
57COPI coating of Golgi vesicle (GO:0048205)3.49867935
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.48785459
59neurotransmitter transport (GO:0006836)3.48695849
60neuromuscular process controlling balance (GO:0050885)3.48516849
61kidney mesenchyme development (GO:0072074)3.45721429
62neuromuscular process controlling posture (GO:0050884)3.43676869
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42221057
64mesenchymal-epithelial cell signaling (GO:0060638)3.41507600
65basement membrane organization (GO:0071711)3.38742288
66regulation of neurotransmitter secretion (GO:0046928)3.37218717
67cell communication by electrical coupling (GO:0010644)3.36439095
68protein carboxylation (GO:0018214)3.35956619
69peptidyl-glutamic acid carboxylation (GO:0017187)3.35956619
70regulation of excitatory postsynaptic membrane potential (GO:0060079)3.35870466
71glycine transport (GO:0015816)3.34655525
72glutamate receptor signaling pathway (GO:0007215)3.32716335
73neurotransmitter-gated ion channel clustering (GO:0072578)3.32311826
74long-term memory (GO:0007616)3.32222174
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.31781710
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.31540074
77protein localization to endosome (GO:0036010)3.31399705
78membrane repolarization (GO:0086009)3.30010455
79regulation of voltage-gated calcium channel activity (GO:1901385)3.27987872
80positive regulation of membrane potential (GO:0045838)3.27942187
81dendritic spine morphogenesis (GO:0060997)3.27454682
82collagen fibril organization (GO:0030199)3.26727368
83regulation of synaptic plasticity (GO:0048167)3.24407896
84mating behavior (GO:0007617)3.22939219
85innervation (GO:0060384)3.21561102
86focal adhesion assembly (GO:0048041)3.21133002
87cell-substrate adherens junction assembly (GO:0007045)3.21133002
88planar cell polarity pathway involved in neural tube closure (GO:0090179)3.20921430
89synaptic vesicle endocytosis (GO:0048488)3.20845992
90regulation of postsynaptic membrane potential (GO:0060078)3.20747438
91neuronal action potential (GO:0019228)3.20166938
92regulation of neurotransmitter levels (GO:0001505)3.18798174
93regulation of neurotransmitter transport (GO:0051588)3.18593025
94axon cargo transport (GO:0008088)3.17497035
95negative regulation of fibrinolysis (GO:0051918)3.17077371
96vesicle transport along microtubule (GO:0047496)3.16581982
97negative regulation of microtubule polymerization (GO:0031115)3.16511411
98adherens junction assembly (GO:0034333)3.14888562
99negative regulation of dendrite development (GO:2000171)3.13685836
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12210999
101positive regulation of neurotransmitter transport (GO:0051590)3.12054780
102regulation of vesicle fusion (GO:0031338)3.11548810
103adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.11029194
104membrane depolarization (GO:0051899)3.10313338
105transmission of nerve impulse (GO:0019226)3.09703300
106membrane hyperpolarization (GO:0060081)3.09453120
107positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09348941
108protein hydroxylation (GO:0018126)3.09272976
109negative regulation of cation channel activity (GO:2001258)3.07811394
110negative regulation of fatty acid transport (GO:2000192)3.06443940
111response to auditory stimulus (GO:0010996)3.03090335
112establishment of apical/basal cell polarity (GO:0035089)3.02792149
113regulation of dendritic spine morphogenesis (GO:0061001)3.02727537
114regulation of synaptic transmission, glutamatergic (GO:0051966)3.02481285
115mesodermal cell differentiation (GO:0048333)3.01945211
116positive regulation of synapse maturation (GO:0090129)3.01338482
117dopamine receptor signaling pathway (GO:0007212)3.01107902
118striatum development (GO:0021756)3.00893247
119positive regulation of potassium ion transmembrane transport (GO:1901381)3.00408965
120cellular response to vitamin (GO:0071295)3.00381083
121potassium ion homeostasis (GO:0055075)3.00094850
122hypotonic response (GO:0006971)2.99967390
123detection of temperature stimulus involved in sensory perception (GO:0050961)2.99249948
124detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.99249948
125paraxial mesoderm development (GO:0048339)2.98739059
126neuronal ion channel clustering (GO:0045161)2.97248839
127neuromuscular process (GO:0050905)2.95422450
128detection of temperature stimulus (GO:0016048)2.95069832
129synaptic transmission (GO:0007268)2.93538938
130cellular response to vitamin D (GO:0071305)2.93079814
131cellular sodium ion homeostasis (GO:0006883)2.93067185
132positive regulation of endothelial cell apoptotic process (GO:2000353)2.92831042
133auditory behavior (GO:0031223)2.92272337
134regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.91288251
135regulation of extracellular matrix disassembly (GO:0010715)2.91164862
136long-term synaptic potentiation (GO:0060291)2.90947184
137cell communication involved in cardiac conduction (GO:0086065)2.90448828
138synaptic transmission, dopaminergic (GO:0001963)2.90246641
139dendrite morphogenesis (GO:0048813)2.89812258
140neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.88432900
141regulation of early endosome to late endosome transport (GO:2000641)2.87050449
142cell migration involved in sprouting angiogenesis (GO:0002042)2.84788588
143type B pancreatic cell proliferation (GO:0044342)2.82641793
144regulation of fibrinolysis (GO:0051917)2.82582358
145sequestering of extracellular ligand from receptor (GO:0035581)2.82072166
146positive regulation of osteoblast proliferation (GO:0033690)2.81421127
147stress fiber assembly (GO:0043149)2.80813642
148regulation of metalloenzyme activity (GO:0048552)2.79889589
149protein maturation by protein folding (GO:0022417)2.78896066
150extracellular matrix assembly (GO:0085029)2.76014723
151peptidyl-proline hydroxylation (GO:0019511)2.75996766
152daunorubicin metabolic process (GO:0044597)2.75982227
153polyketide metabolic process (GO:0030638)2.75982227
154doxorubicin metabolic process (GO:0044598)2.75982227
155regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.75143558
156endocytic recycling (GO:0032456)2.73571668
157epithelial cell-cell adhesion (GO:0090136)2.71901831
158positive regulation of extracellular matrix organization (GO:1903055)2.71254754
159G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.71226800
160actin filament depolymerization (GO:0030042)2.70313240
161cytoskeletal anchoring at plasma membrane (GO:0007016)2.68808436
162heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.67625796
163barbed-end actin filament capping (GO:0051016)2.66087911
164nucleotide-sugar biosynthetic process (GO:0009226)2.63434880
165muscle cell migration (GO:0014812)2.63264537
166bone trabecula formation (GO:0060346)2.61036438
167lung vasculature development (GO:0060426)2.59115780
168dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.57178766
169Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.57132515
170negative regulation of osteoblast proliferation (GO:0033689)2.54081015
171cellular response to hepatocyte growth factor stimulus (GO:0035729)2.49954741
172response to hepatocyte growth factor (GO:0035728)2.49954741
173collagen metabolic process (GO:0032963)2.48083567
174mammary gland epithelial cell proliferation (GO:0033598)2.47910165
175apoptotic cell clearance (GO:0043277)2.47287439
176COPII vesicle coating (GO:0048208)2.46658429
177cell migration involved in heart development (GO:0060973)2.45435715
178substrate-dependent cell migration (GO:0006929)2.44540031
179positive regulation of collagen biosynthetic process (GO:0032967)2.44274964
180retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.42757044
181regulation of establishment of planar polarity (GO:0090175)2.41868359
182cochlea morphogenesis (GO:0090103)2.41847505
183activation of Rac GTPase activity (GO:0032863)2.41273265
184blood vessel endothelial cell migration (GO:0043534)2.40803911
185hippo signaling (GO:0035329)2.40677593
186substrate adhesion-dependent cell spreading (GO:0034446)2.40155051
187establishment or maintenance of monopolar cell polarity (GO:0061339)2.39637437
188establishment of monopolar cell polarity (GO:0061162)2.39637437
189aminoglycoside antibiotic metabolic process (GO:0030647)2.38859329
190semaphorin-plexin signaling pathway (GO:0071526)2.37962107
191atrioventricular valve morphogenesis (GO:0003181)2.37838679
192branching involved in mammary gland duct morphogenesis (GO:0060444)2.37101715
193positive regulation of blood vessel endothelial cell migration (GO:0043536)2.36634859
194regulation of transforming growth factor beta1 production (GO:0032908)2.33488293
195metanephric mesenchyme development (GO:0072075)2.33307140
196heparan sulfate proteoglycan metabolic process (GO:0030201)2.32840509
197multicellular organismal macromolecule metabolic process (GO:0044259)2.32752560
198regulation of mammary gland epithelial cell proliferation (GO:0033599)2.32407034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.25962253
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.19318082
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.39093414
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.74947935
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.52886748
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.24357678
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20116574
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13837325
9JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11079265
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.94583525
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.94583525
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.93443353
13GBX2_23144817_ChIP-Seq_PC3_Human2.83972759
14REST_21632747_ChIP-Seq_MESCs_Mouse2.77152129
15* RARB_27405468_Chip-Seq_BRAIN_Mouse2.76430616
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.69669010
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.69331546
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61829881
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52484576
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.49064546
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47939586
22DROSHA_22980978_ChIP-Seq_HELA_Human2.47853675
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44923436
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.40680666
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.38527586
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36309047
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.34361327
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.33348798
29ELK3_25401928_ChIP-Seq_HUVEC_Human2.26207937
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.24507102
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.21210381
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18985264
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.15516573
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15163325
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.11348096
36IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11197520
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08339442
38* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.08318112
39CLOCK_20551151_ChIP-Seq_293T_Human2.07958259
40TP53_22127205_ChIP-Seq_IMR90_Human1.98314363
41RACK7_27058665_Chip-Seq_MCF-7_Human1.94962583
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85611343
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.84895155
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84586422
45* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.83991371
46* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.82882101
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81983091
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80657561
49* ATF3_27146783_Chip-Seq_COLON_Human1.77714260
50* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.77629343
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71515703
52LXR_22292898_ChIP-Seq_THP-1_Human1.71047347
53BRD4_25478319_ChIP-Seq_HGPS_Human1.70003238
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69898101
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69898101
56AR_21572438_ChIP-Seq_LNCaP_Human1.68686946
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63937268
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58619089
59AR_21909140_ChIP-Seq_LNCAP_Human1.56510227
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53398187
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52539579
62TAF15_26573619_Chip-Seq_HEK293_Human1.52011516
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51507606
64SMAD4_21799915_ChIP-Seq_A2780_Human1.50688821
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.45835559
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44671906
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43032075
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42689561
69* KDM2B_26808549_Chip-Seq_K562_Human1.42330651
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42251534
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40633508
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.40034618
73RXR_22158963_ChIP-Seq_LIVER_Mouse1.39648010
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36670912
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.35307357
76SOX2_20726797_ChIP-Seq_SW620_Human1.35277193
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.35147751
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33397031
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32807243
80* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32314613
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31555954
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31452554
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29354475
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28929962
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28272507
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27558865
87CJUN_26792858_Chip-Seq_BT549_Human1.26845431
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25459139
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25011799
90* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25003355
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24020053
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23923809
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22513282
94SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20543037
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20040831
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19288313
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.18496489
98TP53_23651856_ChIP-Seq_MEFs_Mouse1.18354444
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16984535
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16851705
101* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16810440
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16353554
103FOXA2_19822575_ChIP-Seq_HepG2_Human1.15802248
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15558232
105AR_19668381_ChIP-Seq_PC3_Human1.15203372
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14920793
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14850614
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14297817
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13449423
110P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12831592
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12731773
112RING1B_27294783_Chip-Seq_NPCs_Mouse1.12300452
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11530277
114SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11261787
115SMAD_19615063_ChIP-ChIP_OVARY_Human1.11072589
116TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09900554
117* CTCF_27219007_Chip-Seq_Bcells_Human1.09817292
118EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09139463
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09036273
120P300_19829295_ChIP-Seq_ESCs_Human1.08758145
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08636818
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08418276
123STAT3_23295773_ChIP-Seq_U87_Human1.07203114
124AR_25329375_ChIP-Seq_VCAP_Human1.06671428
125TET1_21490601_ChIP-Seq_MESCs_Mouse1.06300910
126NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06197448
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06108369
128MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06024799
129AHR_22903824_ChIP-Seq_MCF-7_Human1.05962650
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05334540
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05171961
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03728442
133PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03625363
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03502294
135* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03085062
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02036427
137JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01966826
138* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00918748
139FOXO3_23340844_ChIP-Seq_DLD1_Human1.00617600
140ZNF274_21170338_ChIP-Seq_K562_Hela1.00593362
141TET1_21451524_ChIP-Seq_MESCs_Mouse1.00333232
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99606170
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.99417805
144CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99417106
145SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98647578
146CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98453896
147EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98209332
148ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97765396
149TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96912653
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.96801360
151GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96502055
152ESR1_21235772_ChIP-Seq_MCF-7_Human0.96494161
153STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96243928
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.95966647
155ARNT_22903824_ChIP-Seq_MCF-7_Human0.95649860
156SMAD4_21741376_ChIP-Seq_HESCs_Human0.95500602
157OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94109934
158YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92504969
159MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91061308
160SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90848386
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.90194303
162RNF2_27304074_Chip-Seq_NSC_Mouse0.89665278
163THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89307994
164OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88883409
165TCF4_23295773_ChIP-Seq_U87_Human0.87834724
166ZNF263_19887448_ChIP-Seq_K562_Human0.86942912
167SMAD3_21741376_ChIP-Seq_HESCs_Human0.86718032
168RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86573703
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.85812650
170TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85347753
171CBX2_27304074_Chip-Seq_ESCs_Mouse0.85042456
172GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84449840
173TP53_20018659_ChIP-ChIP_R1E_Mouse0.84388209
174ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83821941
175ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83598098
176ESR2_21235772_ChIP-Seq_MCF-7_Human0.82511619
177KLF4_19829295_ChIP-Seq_ESCs_Human0.82190214
178SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81692860
179TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80326794
180AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80289542
181ESR1_20079471_ChIP-ChIP_T-47D_Human0.80001232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.19450354
2MP0008438_abnormal_cutaneous_collagen5.61263629
3MP0003705_abnormal_hypodermis_morpholog4.42401245
4MP0004272_abnormal_basement_membrane4.30457818
5MP0003880_abnormal_central_pattern4.15798586
6MP0004270_analgesia4.04968442
7MP0003635_abnormal_synaptic_transmissio3.91373948
8MP0001968_abnormal_touch/_nociception3.91067692
9MP0002735_abnormal_chemical_nociception3.37101699
10MP0002822_catalepsy3.27168056
11MP0005257_abnormal_intraocular_pressure3.26095321
12MP0002734_abnormal_mechanical_nocicepti3.20238070
13MP0002736_abnormal_nociception_after3.18396210
14MP0009745_abnormal_behavioral_response3.12114446
15MP0003566_abnormal_cell_adhesion3.06966299
16MP0002063_abnormal_learning/memory/cond3.04453367
17MP0002064_seizures2.96365582
18MP0003941_abnormal_skin_development2.89551113
19MP0009046_muscle_twitch2.88949155
20MP0002733_abnormal_thermal_nociception2.76548638
21MP0002272_abnormal_nervous_system2.72610359
22MP0003950_abnormal_plasma_membrane2.71150932
23MP0001970_abnormal_pain_threshold2.60395963
24MP0004858_abnormal_nervous_system2.58296445
25MP0005423_abnormal_somatic_nervous2.52464700
26MP0002572_abnormal_emotion/affect_behav2.51158887
27MP0001958_emphysema2.46779049
28MP0005503_abnormal_tendon_morphology2.45167814
29MP0003279_aneurysm2.45120565
30MP0001486_abnormal_startle_reflex2.36631010
31MP0009384_cardiac_valve_regurgitation2.22279242
32MP0005023_abnormal_wound_healing2.17843017
33MP0001984_abnormal_olfaction2.17785868
34MP0002877_abnormal_melanocyte_morpholog2.10915172
35MP0005275_abnormal_skin_tensile2.09499670
36MP0006276_abnormal_autonomic_nervous2.08747306
37MP0002067_abnormal_sensory_capabilities2.05874062
38MP0002184_abnormal_innervation2.05239122
39MP0002909_abnormal_adrenal_gland1.97500423
40MP0001501_abnormal_sleep_pattern1.96079281
41MP0010368_abnormal_lymphatic_system1.96078605
42MP0004811_abnormal_neuron_physiology1.91172067
43MP0001440_abnormal_grooming_behavior1.90859645
44MP0001542_abnormal_bone_strength1.88323594
45MP0010030_abnormal_orbit_morphology1.85712735
46MP0008569_lethality_at_weaning1.85599118
47MP0003329_amyloid_beta_deposits1.82032246
48MP0002060_abnormal_skin_morphology1.80567744
49MP0010352_gastrointestinal_tract_polyps1.75868594
50MP0003091_abnormal_cell_migration1.73095626
51MP0006054_spinal_hemorrhage1.71651998
52MP0000955_abnormal_spinal_cord1.69697953
53MP0000762_abnormal_tongue_morphology1.65853427
54MP0009780_abnormal_chondrocyte_physiolo1.64896946
55MP0002089_abnormal_postnatal_growth/wei1.64614306
56MP0005386_behavior/neurological_phenoty1.61752036
57MP0004924_abnormal_behavior1.61752036
58MP0002557_abnormal_social/conspecific_i1.58281123
59MP0002882_abnormal_neuron_morphology1.51081132
60MP0003879_abnormal_hair_cell1.49260367
61MP0009053_abnormal_anal_canal1.49082969
62MP0000778_abnormal_nervous_system1.48298691
63MP0000767_abnormal_smooth_muscle1.42999671
64MP0003942_abnormal_urinary_system1.42294700
65MP0005508_abnormal_skeleton_morphology1.41679468
66MP0000003_abnormal_adipose_tissue1.40085175
67MP0002066_abnormal_motor_capabilities/c1.37999809
68MP0003633_abnormal_nervous_system1.37954128
69MP0002295_abnormal_pulmonary_circulatio1.35473552
70MP0002896_abnormal_bone_mineralization1.35274701
71MP0001849_ear_inflammation1.33334454
72MP0009250_abnormal_appendicular_skeleto1.28240481
73MP0005360_urolithiasis1.22373848
74MP0004885_abnormal_endolymph1.20913066
75MP0002229_neurodegeneration1.20888098
76MP0005646_abnormal_pituitary_gland1.20844230
77MP0005551_abnormal_eye_electrophysiolog1.20682562
78MP0001905_abnormal_dopamine_level1.19537171
79MP0001986_abnormal_taste_sensitivity1.16211069
80MP0005409_darkened_coat_color1.14087197
81MP0001502_abnormal_circadian_rhythm1.13420241
82MP0004142_abnormal_muscle_tone1.13300482
83MP0000566_synostosis1.12236261
84MP0003631_nervous_system_phenotype1.12221434
85MP0001529_abnormal_vocalization1.09326531
86MP0003385_abnormal_body_wall1.08673652
87MP0001243_abnormal_dermal_layer1.08101795
88MP0000751_myopathy1.08075681
89MP0000733_abnormal_muscle_development1.07083258
90MP0009840_abnormal_foam_cell1.06744738
91MP0005394_taste/olfaction_phenotype1.06694468
92MP0005499_abnormal_olfactory_system1.06694468
93MP0008874_decreased_physiological_sensi1.03060164
94MP0000467_abnormal_esophagus_morphology1.01679745
95MP0000428_abnormal_craniofacial_morphol1.01202841
96MP0001915_intracranial_hemorrhage1.01103909
97MP0002796_impaired_skin_barrier1.00954421
98MP0003634_abnormal_glial_cell0.97612272
99MP0003453_abnormal_keratinocyte_physiol0.97373735
100MP0002090_abnormal_vision0.96974366
101MP0005501_abnormal_skin_physiology0.96426624
102MP0000462_abnormal_digestive_system0.95369319
103MP0008872_abnormal_physiological_respon0.94713768
104MP0002152_abnormal_brain_morphology0.94572658
105MP0008961_abnormal_basal_metabolism0.94417129
106MP0002752_abnormal_somatic_nervous0.93854360
107MP0010386_abnormal_urinary_bladder0.93658398
108MP0003283_abnormal_digestive_organ0.93301446
109MP0005076_abnormal_cell_differentiation0.91617753
110MP0004145_abnormal_muscle_electrophysio0.91225742
111MP0003123_paternal_imprinting0.90191576
112MP0002254_reproductive_system_inflammat0.89911912
113MP0000013_abnormal_adipose_tissue0.89764417
114MP0001188_hyperpigmentation0.88589931
115MP0000858_altered_metastatic_potential0.87005613
116MP0005595_abnormal_vascular_smooth0.86829013
117MP0003191_abnormal_cellular_cholesterol0.86714384
118MP0005164_abnormal_response_to0.86130092
119MP0010234_abnormal_vibrissa_follicle0.85537099
120MP0003787_abnormal_imprinting0.84076039
121MP0000920_abnormal_myelination0.83510955
122MP0001661_extended_life_span0.83211442
123MP0002069_abnormal_eating/drinking_beha0.82622457
124MP0003115_abnormal_respiratory_system0.82092650
125MP0005645_abnormal_hypothalamus_physiol0.82052399
126MP0004085_abnormal_heartbeat0.81960909
127MP0003075_altered_response_to0.81879300
128MP0004742_abnormal_vestibular_system0.81293142
129MP0003755_abnormal_palate_morphology0.81054307
130MP0005535_abnormal_body_temperature0.80144030
131MP0000604_amyloidosis0.79817620
132MP0010771_integument_phenotype0.79329948
133MP0003937_abnormal_limbs/digits/tail_de0.78779299
134MP0002638_abnormal_pupillary_reflex0.78545128
135MP0002751_abnormal_autonomic_nervous0.76224861
136MP0002108_abnormal_muscle_morphology0.75952366
137MP0000432_abnormal_head_morphology0.75590258
138MP0001177_atelectasis0.75234088
139MP0005197_abnormal_uvea_morphology0.74741483
140MP0002249_abnormal_larynx_morphology0.74168132
141MP0000163_abnormal_cartilage_morphology0.72191473
142MP0004185_abnormal_adipocyte_glucose0.71420751
143MP0001963_abnormal_hearing_physiology0.71397784
144MP0001299_abnormal_eye_distance/0.71168878
145MP0000759_abnormal_skeletal_muscle0.70306130
146MP0003632_abnormal_nervous_system0.70172260
147MP0005451_abnormal_body_composition0.68230416
148MP0005623_abnormal_meninges_morphology0.68135056
149MP0000579_abnormal_nail_morphology0.67030327
150MP0003122_maternal_imprinting0.66619143
151MP0005165_increased_susceptibility_to0.66187080
152MP0000569_abnormal_digit_pigmentation0.65685137
153MP0000678_abnormal_parathyroid_gland0.65522076
154MP0002177_abnormal_outer_ear0.64583376
155MP0001614_abnormal_blood_vessel0.64574208
156MP0000750_abnormal_muscle_regeneration0.64230590
157MP0001664_abnormal_digestion0.63620380
158MP0002697_abnormal_eye_size0.63434026
159MP0001348_abnormal_lacrimal_gland0.63118626
160MP0002128_abnormal_blood_circulation0.61785434
161MP0004134_abnormal_chest_morphology0.60360541
162MP0003935_abnormal_craniofacial_develop0.60267433
163MP0001216_abnormal_epidermal_layer0.59621715
164MP0005193_abnormal_anterior_eye0.59409655
165MP0002114_abnormal_axial_skeleton0.58643439
166MP0003137_abnormal_impulse_conducting0.58615416
167MP0002925_abnormal_cardiovascular_devel0.58423971
168MP0002139_abnormal_hepatobiliary_system0.58208642
169MP0002113_abnormal_skeleton_development0.57862112
170MP0003690_abnormal_glial_cell0.57538323
171MP0000537_abnormal_urethra_morphology0.56645644
172MP0006072_abnormal_retinal_apoptosis0.56472050
173MP0000747_muscle_weakness0.55970485
174MP0001485_abnormal_pinna_reflex0.55173637
175MP0002837_dystrophic_cardiac_calcinosis0.54921537
176MP0004233_abnormal_muscle_weight0.54533710
177MP0000534_abnormal_ureter_morphology0.54203432
178MP0004484_altered_response_of0.51955985
179MP0004215_abnormal_myocardial_fiber0.51893748
180MP0005253_abnormal_eye_physiology0.51721853
181MP0003172_abnormal_lysosome_physiology0.51672406
182MP0001943_abnormal_respiration0.50640772
183MP0004510_myositis0.49434690

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.32437492
2Premature rupture of membranes (HP:0001788)6.63492891
3Protrusio acetabuli (HP:0003179)6.39080244
4Focal motor seizures (HP:0011153)6.34514641
5Focal seizures (HP:0007359)5.23688180
6Action tremor (HP:0002345)4.95652852
7Visual hallucinations (HP:0002367)4.93849141
8Febrile seizures (HP:0002373)4.68123901
9Ankle contracture (HP:0006466)4.48282887
10Atonic seizures (HP:0010819)4.48269889
11Progressive cerebellar ataxia (HP:0002073)4.36723904
12Follicular hyperkeratosis (HP:0007502)4.11008700
13Vascular tortuosity (HP:0004948)4.08805188
14Epileptic encephalopathy (HP:0200134)3.92548589
15Absence seizures (HP:0002121)3.89119098
16Spinal rigidity (HP:0003306)3.87399853
17Supranuclear gaze palsy (HP:0000605)3.81883004
18Ankle clonus (HP:0011448)3.63978001
19Atrophic scars (HP:0001075)3.62268529
20Type 1 muscle fiber predominance (HP:0003803)3.61602176
21Generalized tonic-clonic seizures (HP:0002069)3.60509098
22Arterial tortuosity (HP:0005116)3.60277400
23Fragile skin (HP:0001030)3.52191041
24Abnormality of dentin (HP:0010299)3.49293911
25Dialeptic seizures (HP:0011146)3.46795328
26Achilles tendon contracture (HP:0001771)3.46431616
27Mildly elevated creatine phosphokinase (HP:0008180)3.45259082
28Ulnar claw (HP:0001178)3.44862499
29Aortic aneurysm (HP:0004942)3.44128617
30Aortic dissection (HP:0002647)3.43592749
31Termporal pattern (HP:0011008)3.41598890
32Insidious onset (HP:0003587)3.41598890
33Abnormality of the Achilles tendon (HP:0005109)3.40238489
34Slender build (HP:0001533)3.33304849
35Depression (HP:0000716)3.29416731
36Neonatal short-limb short stature (HP:0008921)3.27038656
37Pheochromocytoma (HP:0002666)3.26979151
38Bladder diverticulum (HP:0000015)3.20386757
39Wormian bones (HP:0002645)3.15503787
40Truncal ataxia (HP:0002078)3.08086363
41Shallow orbits (HP:0000586)3.07624887
42Urinary bladder sphincter dysfunction (HP:0002839)3.05242851
43Gaze-evoked nystagmus (HP:0000640)3.04660079
44Soft skin (HP:0000977)3.04154320
45Anxiety (HP:0000739)2.97830514
46Ventricular fibrillation (HP:0001663)2.97557382
47Upper limb amyotrophy (HP:0009129)2.96998171
48Distal upper limb amyotrophy (HP:0007149)2.96998171
49Torticollis (HP:0000473)2.95836057
50Impaired vibration sensation in the lower limbs (HP:0002166)2.88220014
51Annular pancreas (HP:0001734)2.87967361
52Distal lower limb amyotrophy (HP:0008944)2.87904442
53Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.84633910
54Short nail (HP:0001799)2.84373120
55Abnormality of the lower motor neuron (HP:0002366)2.83991034
56Peripheral hypomyelination (HP:0007182)2.83922364
57Ulnar bowing (HP:0003031)2.82470239
58Elbow flexion contracture (HP:0002987)2.82406840
59Neuroendocrine neoplasm (HP:0100634)2.81807986
60Vertebral compression fractures (HP:0002953)2.80005260
61Dysmetria (HP:0001310)2.79624834
62Poor eye contact (HP:0000817)2.79546457
63Genu recurvatum (HP:0002816)2.78479611
64Urinary urgency (HP:0000012)2.78167292
65Cardiovascular calcification (HP:0011915)2.77701646
66Deep venous thrombosis (HP:0002625)2.75197553
67Amblyopia (HP:0000646)2.74494220
68Dysdiadochokinesis (HP:0002075)2.71896212
69Focal dystonia (HP:0004373)2.70286202
70Mutism (HP:0002300)2.68132181
71Papilledema (HP:0001085)2.65665390
72Broad metatarsal (HP:0001783)2.65641957
73Abnormal eating behavior (HP:0100738)2.65620895
74Limb dystonia (HP:0002451)2.65267123
75Coronal craniosynostosis (HP:0004440)2.63275626
76Cervical subluxation (HP:0003308)2.61487643
77Postural instability (HP:0002172)2.59711957
78Craniofacial dystonia (HP:0012179)2.58781379
79Impaired social interactions (HP:0000735)2.57422170
80Abnormal social behavior (HP:0012433)2.57422170
81Mitral regurgitation (HP:0001653)2.56717859
82Abnormality of carpal bone ossification (HP:0006257)2.56414085
83Blue sclerae (HP:0000592)2.51951136
84Generalized amyotrophy (HP:0003700)2.51670883
85Scanning speech (HP:0002168)2.49809342
86Spastic gait (HP:0002064)2.47770011
87Broad-based gait (HP:0002136)2.46007013
88Vascular calcification (HP:0004934)2.43684410
89Hypercortisolism (HP:0001578)2.41402242
90Bowel diverticulosis (HP:0005222)2.40483262
91Megalencephaly (HP:0001355)2.39231759
92Hyperacusis (HP:0010780)2.38399770
93Lower limb amyotrophy (HP:0007210)2.37439799
94Abnormal delivery (HP:0001787)2.36994733
95Abnormality of pain sensation (HP:0010832)2.35962744
96Impaired pain sensation (HP:0007328)2.35962744
97Increased connective tissue (HP:0009025)2.34682063
98Postural tremor (HP:0002174)2.34448623
99Increased variability in muscle fiber diameter (HP:0003557)2.31186478
100Hyperextensible skin (HP:0000974)2.29698787
101Hammertoe (HP:0001765)2.29301805
102Bradykinesia (HP:0002067)2.29258797
103Peritonitis (HP:0002586)2.29218423
104Insomnia (HP:0100785)2.28515791
105Abnormal ossification of hand bones (HP:0005921)2.28497355
106Myotonia (HP:0002486)2.27918804
107Genetic anticipation (HP:0003743)2.27899830
108Abnormality of the acetabulum (HP:0003170)2.27495777
109Biconcave vertebral bodies (HP:0004586)2.24798162
110Failure to thrive in infancy (HP:0001531)2.24749382
111Neoplasm of the peripheral nervous system (HP:0100007)2.24660205
112Dilatation of the ascending aorta (HP:0005111)2.23991139
113Progressive inability to walk (HP:0002505)2.23456545
114Cholecystitis (HP:0001082)2.23276317
115Abnormal gallbladder physiology (HP:0012438)2.23276317
116Mitral valve prolapse (HP:0001634)2.21968727
117Impaired smooth pursuit (HP:0007772)2.20650176
118Renal duplication (HP:0000075)2.19196354
119Joint laxity (HP:0001388)2.18889832
120Hand muscle atrophy (HP:0009130)2.16162663
121Pointed chin (HP:0000307)2.13807400
122Natal tooth (HP:0000695)2.11695556
123Lower limb muscle weakness (HP:0007340)2.11151497
124Mitral stenosis (HP:0001718)2.10077682
125Intention tremor (HP:0002080)2.09974117
126Bundle branch block (HP:0011710)2.09513605
127Resting tremor (HP:0002322)2.09056340
128Hypoventilation (HP:0002791)2.07821387
129Stereotypic behavior (HP:0000733)2.07416897
130Agitation (HP:0000713)2.06549187
131Protruding ear (HP:0000411)2.06298476
132Wide anterior fontanel (HP:0000260)2.05595261
133Bowed forearm bones (HP:0003956)2.05426158
134Bowing of the arm (HP:0006488)2.05426158
135Rapidly progressive (HP:0003678)2.05063976
136Dysmetric saccades (HP:0000641)2.04290745
137Disproportionate tall stature (HP:0001519)2.04271110
138Abnormality of the corticospinal tract (HP:0002492)2.04184060
139Lower limb asymmetry (HP:0100559)2.03879752
140Abnormality of skeletal muscle fiber size (HP:0012084)2.03604785
141Abnormality of ocular smooth pursuit (HP:0000617)2.03506847
142Long toe (HP:0010511)2.02660034
143Osteolytic defects of the phalanges of the hand (HP:0009771)2.02460596
144Osteolytic defects of the hand bones (HP:0009699)2.02460596
145Overgrowth (HP:0001548)2.02196706
146Abnormality of the vocal cords (HP:0008777)1.99999425
147Onion bulb formation (HP:0003383)1.98806567
148Fetal akinesia sequence (HP:0001989)1.97614005
149Foot dorsiflexor weakness (HP:0009027)1.97055462
150Difficulty climbing stairs (HP:0003551)1.96970658
151Central scotoma (HP:0000603)1.95715300
152Limb-girdle muscle weakness (HP:0003325)1.94980914
153Hemiparesis (HP:0001269)1.93860202
154Impaired vibratory sensation (HP:0002495)1.91716850
155Distal lower limb muscle weakness (HP:0009053)1.91614735
156Epileptiform EEG discharges (HP:0011182)1.91480030
157Hemiplegia (HP:0002301)1.91431829
158Neurofibrillary tangles (HP:0002185)1.91120793
159EEG with generalized epileptiform discharges (HP:0011198)1.90573543
160Redundant skin (HP:0001582)1.89945927
161Clonus (HP:0002169)1.89649172
162Spinal canal stenosis (HP:0003416)1.89264917
163Cerebral aneurysm (HP:0004944)1.89111431
164Abnormal EKG (HP:0003115)1.89071175
165Aortic regurgitation (HP:0001659)1.89049147
166Partial duplication of the phalanx of hand (HP:0009999)1.87848294
167Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.87797990
168Cerebral inclusion bodies (HP:0100314)1.87746904
169Obstructive sleep apnea (HP:0002870)1.87595603
170Abnormal hand bone ossification (HP:0010660)1.86454657
171Diplopia (HP:0000651)1.86360275
172Abnormality of binocular vision (HP:0011514)1.86360275
173Aneurysm (HP:0002617)1.86041081
174Decreased motor nerve conduction velocity (HP:0003431)1.85887280
175Gait ataxia (HP:0002066)1.85467712
176Incomplete penetrance (HP:0003829)1.85419021
177Rigidity (HP:0002063)1.84608143
178Aplasia involving bones of the extremities (HP:0009825)1.84577733
179Aplasia involving bones of the upper limbs (HP:0009823)1.84577733
180Aplasia of the phalanges of the hand (HP:0009802)1.84577733
181Neuronal loss in central nervous system (HP:0002529)1.83318642
182Reduced subcutaneous adipose tissue (HP:0003758)1.82777738
183Nonimmune hydrops fetalis (HP:0001790)1.80098258
184Coxa vara (HP:0002812)1.79656268
185Premature skin wrinkling (HP:0100678)1.78439012
186Advanced eruption of teeth (HP:0006288)1.77175213
187Spinal cord compression (HP:0002176)1.76160793
188Arnold-Chiari malformation (HP:0002308)1.75343582
189Deviation of the hallux (HP:0010051)1.74800708
190Acanthosis nigricans (HP:0000956)1.72589961
191Entropion (HP:0000621)1.71906926
192Osteopenia (HP:0000938)1.71594450
193Glucose intolerance (HP:0000833)1.67120023
194Partial duplication of thumb phalanx (HP:0009944)1.66879178
195Trismus (HP:0000211)1.66305670
196Bradycardia (HP:0001662)1.65464754
197Abnormality of the umbilical cord (HP:0010881)1.64295061
198Hallux valgus (HP:0001822)1.64095505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.54554142
2MAP3K94.23661943
3NTRK34.05526206
4EPHA23.73789452
5EPHA43.58261914
6KSR23.37133843
7MET3.30139983
8PDGFRA3.24828751
9MINK13.00679919
10SIK12.91657172
11IRAK32.86176964
12PTK22.79925440
13MYLK2.70898258
14TRIB32.69715744
15MAP3K42.51532521
16NTRK12.49873754
17DAPK22.45206703
18PAK42.36572131
19MAP3K22.33949216
20PAK62.31447932
21GRK52.29447079
22MARK12.19334311
23PRKD32.17386395
24ARAF2.12872433
25CAMKK11.99428708
26MAP2K71.97502573
27TTN1.95218741
28TESK11.94299070
29RIPK41.90672481
30MAP3K121.88480493
31ERBB41.85641009
32DDR21.85429207
33LMTK21.79742551
34MAP2K41.73886455
35EPHB21.72570985
36ICK1.54309812
37NTRK21.53470248
38FLT31.53437776
39STK381.50182434
40CDK51.49162189
41RET1.48279730
42LATS21.47410657
43ERN11.45705081
44PRKD21.45527624
45PAK21.39932348
46PHKG21.34650229
47PHKG11.34650229
48AKT31.34456626
49PINK11.34322566
50EPHB11.28341313
51TAOK11.22793263
52DAPK11.22439147
53PLK21.20180197
54CAMKK21.19974862
55MAPK131.19969480
56LATS11.19537656
57PRKG21.15636520
58KSR11.14853679
59FGFR41.14110078
60LIMK11.12917683
61UHMK11.12558647
62PTK2B1.09446314
63FES1.07627198
64PRKCG1.07438263
65SIK21.07041860
66MAP3K11.02732568
67CDK81.02544538
68MOS1.01977923
69MAP3K130.99313284
70SGK2230.99056799
71SGK4940.99056799
72CDK140.96720478
73BMX0.94306484
74ABL20.92145858
75SMG10.91283479
76PNCK0.90900195
77PKN20.89717999
78WNK10.88688778
79NEK10.88000793
80PDGFRB0.87977714
81CDK180.87927097
82CDK150.87499730
83PRKCH0.86033064
84PRPF4B0.85436357
85ILK0.83715682
86TAOK20.83434862
87ROCK20.83066773
88CDK190.82072691
89TYRO30.81928199
90RIPK10.81698568
91PTK60.80804021
92MAP2K10.80165378
93TGFBR20.79832790
94CAMK2A0.79298123
95STK110.77516675
96CDK11A0.77323233
97NEK90.76156795
98CAMK10.75165992
99RAF10.73471434
100MTOR0.73360595
101SGK20.72496249
102PAK30.71420247
103TNK20.69673077
104SGK30.68156445
105PDK10.67854055
106ROCK10.67321918
107ALK0.67253340
108DMPK0.65833522
109TNIK0.65794565
110CSNK1G20.63452075
111IRAK20.62429215
112PDPK10.62197709
113CASK0.62117612
114CDK120.61654088
115PBK0.59682959
116MARK20.59314912
117CAMK2B0.59249584
118FER0.58787211
119MAP3K30.57851364
120SCYL20.57304099
121RPS6KA20.56824239
122PIM20.55028597
123PRKCZ0.53591686
124NME20.53111919
125CDC42BPA0.51748023
126CAMK2G0.50605510
127EEF2K0.49577562
128MAPKAPK50.49076291
129CAMK2D0.48103772
130FGFR10.47931152
131DYRK1B0.47775067
132SGK10.45729091
133PAK10.44708029
134BRAF0.44083933
135MAP3K70.43347558
136BMPR20.42827716
137PRKCE0.42771121
138MAPK100.42429024
139DYRK1A0.42036804
140GSK3A0.42006119
141MELK0.41973143
142DAPK30.40369167
143RPS6KA30.40012937
144BRSK10.39837928
145AKT20.39651588
146FYN0.38670596
147STK390.37805128
148WNK40.37613129
149NME10.37058772
150MAP3K80.37054898
151CAMK40.35952944
152PRKCI0.33997222
153CDK70.33122172
154AURKA0.32239818
155HIPK20.30564822
156BUB10.30327152
157OXSR10.30224221
158ADRBK10.29844333
159PRKACA0.29166951
160TRPM70.28673747

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.53916362
2Olfactory transduction_Homo sapiens_hsa047403.15250606
3ECM-receptor interaction_Homo sapiens_hsa045123.07780443
4Nicotine addiction_Homo sapiens_hsa050332.87583263
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.59356537
6GABAergic synapse_Homo sapiens_hsa047272.46155724
7Circadian entrainment_Homo sapiens_hsa047132.45777441
8Focal adhesion_Homo sapiens_hsa045102.44130372
9Long-term potentiation_Homo sapiens_hsa047202.36587543
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33403173
11Morphine addiction_Homo sapiens_hsa050322.30179524
12Glutamatergic synapse_Homo sapiens_hsa047242.29987445
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.25049315
14Vitamin B6 metabolism_Homo sapiens_hsa007502.22351676
15Dopaminergic synapse_Homo sapiens_hsa047282.12463643
16Amphetamine addiction_Homo sapiens_hsa050312.10612621
17Salivary secretion_Homo sapiens_hsa049702.06112878
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.05749173
19Insulin secretion_Homo sapiens_hsa049112.03126651
20Cholinergic synapse_Homo sapiens_hsa047251.96746362
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.94474935
22Proteoglycans in cancer_Homo sapiens_hsa052051.84656831
23Taste transduction_Homo sapiens_hsa047421.76748460
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75142850
25Gastric acid secretion_Homo sapiens_hsa049711.74940872
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73406764
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.72766109
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67955982
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.65040792
30Adherens junction_Homo sapiens_hsa045201.61863890
31Bladder cancer_Homo sapiens_hsa052191.59104030
32Oxytocin signaling pathway_Homo sapiens_hsa049211.50720991
33Cocaine addiction_Homo sapiens_hsa050301.50144261
34Long-term depression_Homo sapiens_hsa047301.49950359
35Complement and coagulation cascades_Homo sapiens_hsa046101.49228342
36Renin secretion_Homo sapiens_hsa049241.48468677
37Serotonergic synapse_Homo sapiens_hsa047261.48467503
38Hippo signaling pathway_Homo sapiens_hsa043901.46050657
39GnRH signaling pathway_Homo sapiens_hsa049121.45395231
40Collecting duct acid secretion_Homo sapiens_hsa049661.45296144
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.44587784
42Phototransduction_Homo sapiens_hsa047441.43859823
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.39197299
44Protein digestion and absorption_Homo sapiens_hsa049741.36793279
45Gap junction_Homo sapiens_hsa045401.36009750
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.35260426
47Calcium signaling pathway_Homo sapiens_hsa040201.35203254
48Tight junction_Homo sapiens_hsa045301.26400974
49Galactose metabolism_Homo sapiens_hsa000521.24153336
50Glioma_Homo sapiens_hsa052141.23933031
51Cardiac muscle contraction_Homo sapiens_hsa042601.22674591
52Type II diabetes mellitus_Homo sapiens_hsa049301.20088762
53N-Glycan biosynthesis_Homo sapiens_hsa005101.19154039
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17353106
55cAMP signaling pathway_Homo sapiens_hsa040241.15369298
56Amoebiasis_Homo sapiens_hsa051461.14237594
57Estrogen signaling pathway_Homo sapiens_hsa049151.13992810
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13925293
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12691114
60Dorso-ventral axis formation_Homo sapiens_hsa043201.09899666
61Small cell lung cancer_Homo sapiens_hsa052221.06987459
62Pentose phosphate pathway_Homo sapiens_hsa000301.01910425
63Melanogenesis_Homo sapiens_hsa049161.00008141
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99809859
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99241770
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99175191
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99122006
68Fructose and mannose metabolism_Homo sapiens_hsa000510.97323390
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97188670
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96784672
71MicroRNAs in cancer_Homo sapiens_hsa052060.94563534
72Basal cell carcinoma_Homo sapiens_hsa052170.94237821
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93497856
74Glutathione metabolism_Homo sapiens_hsa004800.93259865
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92381574
76Vibrio cholerae infection_Homo sapiens_hsa051100.92148323
77ErbB signaling pathway_Homo sapiens_hsa040120.91621201
78Chronic myeloid leukemia_Homo sapiens_hsa052200.91196840
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90969416
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.89284685
81Sulfur metabolism_Homo sapiens_hsa009200.88758275
82Oocyte meiosis_Homo sapiens_hsa041140.87990807
83Nitrogen metabolism_Homo sapiens_hsa009100.85814963
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85644828
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.85273778
86Wnt signaling pathway_Homo sapiens_hsa043100.84733757
87Arginine biosynthesis_Homo sapiens_hsa002200.84673004
88Axon guidance_Homo sapiens_hsa043600.84491086
89Thyroid hormone synthesis_Homo sapiens_hsa049180.84018115
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83244915
91Pancreatic secretion_Homo sapiens_hsa049720.83157886
92Other glycan degradation_Homo sapiens_hsa005110.80727821
93TGF-beta signaling pathway_Homo sapiens_hsa043500.80320099
94Sulfur relay system_Homo sapiens_hsa041220.79727306
95Biosynthesis of amino acids_Homo sapiens_hsa012300.79681901
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.75978673
97Hedgehog signaling pathway_Homo sapiens_hsa043400.75165536
98VEGF signaling pathway_Homo sapiens_hsa043700.75041544
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73929140
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72453936
101Starch and sucrose metabolism_Homo sapiens_hsa005000.71850382
102Pathways in cancer_Homo sapiens_hsa052000.70842352
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.68203161
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67668938
105Selenocompound metabolism_Homo sapiens_hsa004500.66849827
106Choline metabolism in cancer_Homo sapiens_hsa052310.66696607
107Sphingolipid metabolism_Homo sapiens_hsa006000.66592438
108Shigellosis_Homo sapiens_hsa051310.66422082
109mTOR signaling pathway_Homo sapiens_hsa041500.64373214
110Bile secretion_Homo sapiens_hsa049760.63854024
111MAPK signaling pathway_Homo sapiens_hsa040100.63332028
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63211617
113Dilated cardiomyopathy_Homo sapiens_hsa054140.63118243
114Endocytosis_Homo sapiens_hsa041440.63008605
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62724248
116Arginine and proline metabolism_Homo sapiens_hsa003300.62247887
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61809809
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.60900989
119Steroid biosynthesis_Homo sapiens_hsa001000.60212812
120Endometrial cancer_Homo sapiens_hsa052130.60210146
121Insulin signaling pathway_Homo sapiens_hsa049100.60069788
122AMPK signaling pathway_Homo sapiens_hsa041520.59918348
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59246128
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59190661
125Rap1 signaling pathway_Homo sapiens_hsa040150.58066062
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.57755442
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57600254
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.56873131
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55745774
130Non-small cell lung cancer_Homo sapiens_hsa052230.55056381
131Folate biosynthesis_Homo sapiens_hsa007900.54834843
132Ras signaling pathway_Homo sapiens_hsa040140.54227103
133Alcoholism_Homo sapiens_hsa050340.53267267
134Phenylalanine metabolism_Homo sapiens_hsa003600.51676619
135Alzheimers disease_Homo sapiens_hsa050100.51489414
136Glucagon signaling pathway_Homo sapiens_hsa049220.51484802
137Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50151752
138Carbon metabolism_Homo sapiens_hsa012000.49591810
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49284792
140Inositol phosphate metabolism_Homo sapiens_hsa005620.48934173
141Parkinsons disease_Homo sapiens_hsa050120.48714451
142Prostate cancer_Homo sapiens_hsa052150.47662796
143Fatty acid biosynthesis_Homo sapiens_hsa000610.46023317
144Prion diseases_Homo sapiens_hsa050200.45595002
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44012544
146Thyroid cancer_Homo sapiens_hsa052160.43375290
147Circadian rhythm_Homo sapiens_hsa047100.40171330
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38255302
149Renal cell carcinoma_Homo sapiens_hsa052110.36613056
150Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35434909
151Prolactin signaling pathway_Homo sapiens_hsa049170.35378085
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35260336
153Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35025521
154Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34968903
155Melanoma_Homo sapiens_hsa052180.34699768
156Oxidative phosphorylation_Homo sapiens_hsa001900.34549389
157Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33351803
158Chemokine signaling pathway_Homo sapiens_hsa040620.32097536
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31526333
160Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31443283
161Mineral absorption_Homo sapiens_hsa049780.26838329

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