TRNT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.54231839
2regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.24510170
3regulation of mitotic spindle checkpoint (GO:1903504)4.24510170
4axon ensheathment in central nervous system (GO:0032291)4.19550698
5central nervous system myelination (GO:0022010)4.19550698
6replication fork processing (GO:0031297)4.17532313
7proteasome assembly (GO:0043248)4.05338564
8cullin deneddylation (GO:0010388)4.04585462
9CENP-A containing nucleosome assembly (GO:0034080)3.94194162
10chromatin remodeling at centromere (GO:0031055)3.84921140
11ribosome assembly (GO:0042255)3.78318002
12IMP metabolic process (GO:0046040)3.75482279
13protein deneddylation (GO:0000338)3.70819454
14transcription elongation from RNA polymerase I promoter (GO:0006362)3.70084967
15L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.68703501
167-methylguanosine RNA capping (GO:0009452)3.68681528
17RNA capping (GO:0036260)3.68681528
18DNA replication checkpoint (GO:0000076)3.65009451
197-methylguanosine mRNA capping (GO:0006370)3.63673094
20DNA replication initiation (GO:0006270)3.63328629
21IMP biosynthetic process (GO:0006188)3.63051736
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.62217267
23termination of RNA polymerase III transcription (GO:0006386)3.62217267
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.61719180
25protein neddylation (GO:0045116)3.59420425
26transcription initiation from RNA polymerase I promoter (GO:0006361)3.52901557
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49174184
28transcription from RNA polymerase I promoter (GO:0006360)3.48670907
29termination of RNA polymerase I transcription (GO:0006363)3.48507453
30DNA strand elongation involved in DNA replication (GO:0006271)3.46341332
31mitotic metaphase plate congression (GO:0007080)3.44498684
32fatty acid elongation (GO:0030497)3.43733873
33histone mRNA metabolic process (GO:0008334)3.41340899
34nucleobase biosynthetic process (GO:0046112)3.41098574
35recombinational repair (GO:0000725)3.40143629
36regulation of helicase activity (GO:0051095)3.38449091
37double-strand break repair via homologous recombination (GO:0000724)3.38029747
38maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.37541940
39DNA catabolic process, exonucleolytic (GO:0000738)3.35839661
40protein complex biogenesis (GO:0070271)3.34825581
41synapsis (GO:0007129)3.33908808
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33760975
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33122949
44DNA strand elongation (GO:0022616)3.32612971
45purine nucleobase biosynthetic process (GO:0009113)3.32142918
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32020426
47regulation of centriole replication (GO:0046599)3.31711427
48mitochondrial respiratory chain complex assembly (GO:0033108)3.30877812
49negative regulation of neurotransmitter secretion (GO:0046929)3.28785771
50negative regulation of ligase activity (GO:0051352)3.28429606
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28429606
52histone exchange (GO:0043486)3.27923731
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26582240
54somatic hypermutation of immunoglobulin genes (GO:0016446)3.24904546
55somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24904546
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.24124617
57ribosome biogenesis (GO:0042254)3.22354615
58attachment of spindle microtubules to kinetochore (GO:0008608)3.21748266
59kinetochore organization (GO:0051383)3.18686658
60telomere maintenance via semi-conservative replication (GO:0032201)3.17699337
61intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16491276
62signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16491276
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15769491
64telomere maintenance via recombination (GO:0000722)3.14172853
65respiratory chain complex IV assembly (GO:0008535)3.12935293
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.12774719
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.12774719
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.12774719
69rRNA modification (GO:0000154)3.11539352
70DNA replication-independent nucleosome organization (GO:0034724)3.11336393
71DNA replication-independent nucleosome assembly (GO:0006336)3.11336393
72spliceosomal snRNP assembly (GO:0000387)3.08134067
73resolution of meiotic recombination intermediates (GO:0000712)3.04495291
74reciprocal meiotic recombination (GO:0007131)3.04006525
75reciprocal DNA recombination (GO:0035825)3.04006525
76tRNA methylation (GO:0030488)3.03192972
77signal transduction involved in DNA damage checkpoint (GO:0072422)3.03108942
78signal transduction involved in DNA integrity checkpoint (GO:0072401)3.03108942
79regulation of meiosis I (GO:0060631)3.03042223
80maturation of 5.8S rRNA (GO:0000460)2.99108549
81signal transduction involved in cell cycle checkpoint (GO:0072395)2.98928658
82establishment of protein localization to mitochondrial membrane (GO:0090151)2.98526141
83metaphase plate congression (GO:0051310)2.98082589
84mitochondrial RNA metabolic process (GO:0000959)2.97539886
85regulation of nuclear cell cycle DNA replication (GO:0033262)2.96879174
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96816575
87negative regulation of DNA recombination (GO:0045910)2.96035997
88isotype switching (GO:0045190)2.93481181
89somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.93481181
90somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.93481181
91regulation of DNA endoreduplication (GO:0032875)2.93008214
92long-chain fatty acid biosynthetic process (GO:0042759)2.91789811
93energy coupled proton transport, down electrochemical gradient (GO:0015985)2.91708962
94ATP synthesis coupled proton transport (GO:0015986)2.91708962
95regulation of cellular amino acid metabolic process (GO:0006521)2.91535225
96formation of translation preinitiation complex (GO:0001731)2.91375346
97DNA replication-dependent nucleosome organization (GO:0034723)2.89442441
98centriole replication (GO:0007099)2.89387553
99mitotic recombination (GO:0006312)2.89319016
100cell cycle G1/S phase transition (GO:0044843)2.89282853
101G1/S transition of mitotic cell cycle (GO:0000082)2.89282853
102establishment of integrated proviral latency (GO:0075713)2.88455968
103ribonucleoprotein complex biogenesis (GO:0022613)2.88112759
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88079307
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86956290
106rRNA methylation (GO:0031167)2.86946290
107transcription-coupled nucleotide-excision repair (GO:0006283)2.86235693
108pseudouridine synthesis (GO:0001522)2.86087537
109rRNA processing (GO:0006364)2.85679470
110meiotic chromosome segregation (GO:0045132)2.85590021
111regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.84740841
112kinetochore assembly (GO:0051382)2.84004250
113mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83644467
114cytochrome complex assembly (GO:0017004)2.83196954
115DNA-templated transcription, elongation (GO:0006354)2.82152807
116mismatch repair (GO:0006298)2.79658149
117DNA deamination (GO:0045006)2.78126906
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77395254
119transcription elongation from RNA polymerase II promoter (GO:0006368)2.77364801
120positive regulation of ligase activity (GO:0051351)2.76524471
121nuclear pore organization (GO:0006999)2.75742783
122DNA ligation (GO:0006266)2.75125232
123postreplication repair (GO:0006301)2.75041962
124ribosomal large subunit biogenesis (GO:0042273)2.74957376
125establishment of chromosome localization (GO:0051303)2.74149601
126rRNA metabolic process (GO:0016072)2.73938507
127tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73694173
128RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73694173
129regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73165189
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.72049848
131NADH dehydrogenase complex assembly (GO:0010257)2.72049848
132mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72049848
133DNA unwinding involved in DNA replication (GO:0006268)2.71937281
134DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.70511681
135amino acid salvage (GO:0043102)2.69647207
136L-methionine salvage (GO:0071267)2.69647207
137L-methionine biosynthetic process (GO:0071265)2.69647207
138peptidyl-histidine modification (GO:0018202)2.69481544
139microtubule polymerization or depolymerization (GO:0031109)2.68951841
140platelet dense granule organization (GO:0060155)2.68517537
141establishment of viral latency (GO:0019043)2.67873997
142regulation of ubiquitin-protein transferase activity (GO:0051438)2.67275904
143telomere maintenance via telomere lengthening (GO:0010833)2.67083116
144DNA replication-dependent nucleosome assembly (GO:0006335)2.66605049
145response to X-ray (GO:0010165)2.66441962
146histone H2A acetylation (GO:0043968)2.65917353
147chaperone-mediated protein transport (GO:0072321)2.62696777
148somatic diversification of immunoglobulins (GO:0016445)2.62434261
149ubiquinone metabolic process (GO:0006743)2.62167056
150water-soluble vitamin biosynthetic process (GO:0042364)2.61562463
151histone mRNA catabolic process (GO:0071044)2.60305218
152DNA recombination (GO:0006310)2.58619138
153protein-cofactor linkage (GO:0018065)2.58024820
154double-strand break repair via nonhomologous end joining (GO:0006303)2.55966216
155non-recombinational repair (GO:0000726)2.55966216
156transcription from mitochondrial promoter (GO:0006390)2.55255349
157nucleotide-excision repair, DNA gap filling (GO:0006297)2.55239774
158rRNA catabolic process (GO:0016075)2.54575713
159lactate metabolic process (GO:0006089)2.54066881
160somatic recombination of immunoglobulin gene segments (GO:0016447)2.53736093
161protein K11-linked deubiquitination (GO:0035871)2.53543511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.61073191
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.54185921
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.20883820
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.90836221
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.76224567
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.49937882
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36795587
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20953919
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.20444243
10* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.98910117
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.94572883
12ZNF274_21170338_ChIP-Seq_K562_Hela2.89478197
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87809965
14ELK1_19687146_ChIP-ChIP_HELA_Human2.71890266
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67585219
16* VDR_23849224_ChIP-Seq_CD4+_Human2.63923916
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62535053
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59820813
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54458594
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37607658
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29971029
22* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25820453
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22676692
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.20991935
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20489864
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16581907
27IGF1R_20145208_ChIP-Seq_DFB_Human2.14195961
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09710109
29FOXP3_21729870_ChIP-Seq_TREG_Human2.08342947
30DCP1A_22483619_ChIP-Seq_HELA_Human2.08027480
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03387211
32AR_21909140_ChIP-Seq_LNCAP_Human2.00364126
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.99776357
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99142581
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94846294
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90872296
37* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86998631
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86617876
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85552643
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84320662
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83151555
42XRN2_22483619_ChIP-Seq_HELA_Human1.76000539
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72277428
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71335601
45GABP_19822575_ChIP-Seq_HepG2_Human1.70900379
46P300_19829295_ChIP-Seq_ESCs_Human1.68186418
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68025757
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63777238
49GBX2_23144817_ChIP-Seq_PC3_Human1.63687069
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63542850
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59471116
52TTF2_22483619_ChIP-Seq_HELA_Human1.55980691
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52522281
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47198903
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45780996
56FUS_26573619_Chip-Seq_HEK293_Human1.44832625
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44017174
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.43640642
59* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43253968
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.41345441
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39904189
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39131651
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.39088203
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36624005
65* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29923492
66IRF1_19129219_ChIP-ChIP_H3396_Human1.28532275
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27705839
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25840907
69TP53_22573176_ChIP-Seq_HFKS_Human1.25722224
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24614930
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24326867
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.24320411
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24318494
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24104279
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.21936392
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21333909
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.20396414
78MYC_18940864_ChIP-ChIP_HL60_Human1.19826573
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19054332
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17829048
81EWS_26573619_Chip-Seq_HEK293_Human1.17360047
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16077088
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14255561
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14164268
85CBP_20019798_ChIP-Seq_JUKART_Human1.14164268
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.12006303
87* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11711777
88* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11081256
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08929955
90KDM5A_27292631_Chip-Seq_BREAST_Human1.07660629
91ELK1_22589737_ChIP-Seq_MCF10A_Human1.06652734
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05465426
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05052999
94SMAD4_21799915_ChIP-Seq_A2780_Human1.04250548
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03716342
96SOX17_20123909_ChIP-Seq_XEN_Mouse1.03194173
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02299900
98BCAT_22108803_ChIP-Seq_LS180_Human1.01623968
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00911389
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00432324
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99952006
102SOX2_19829295_ChIP-Seq_ESCs_Human0.99531906
103NANOG_19829295_ChIP-Seq_ESCs_Human0.99531906
104STAT3_23295773_ChIP-Seq_U87_Human0.99280087
105NANOG_18555785_Chip-Seq_ESCs_Mouse0.98360937
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97212110
107* FOXA1_25329375_ChIP-Seq_VCAP_Human0.96918204
108* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96918204
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.96513096
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.95679539
111CRX_20693478_ChIP-Seq_RETINA_Mouse0.95550442
112TFEB_21752829_ChIP-Seq_HELA_Human0.95140617
113* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94011886
114P53_22387025_ChIP-Seq_ESCs_Mouse0.93230202
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92685010
116AR_25329375_ChIP-Seq_VCAP_Human0.92244132
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.91412540
118E2F1_18555785_Chip-Seq_ESCs_Mouse0.91372223
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91243410
120* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91053811
121STAT3_18555785_Chip-Seq_ESCs_Mouse0.90879034
122TCF4_22108803_ChIP-Seq_LS180_Human0.90683389
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90512882
124IRF8_21731497_ChIP-ChIP_J774_Mouse0.89271270
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88920288
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87841576
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86372498
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85692919
129* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85562550
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85146600
131NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84495048
132TAF15_26573619_Chip-Seq_HEK293_Human0.83018135
133* SPI1_23547873_ChIP-Seq_NB4_Human0.82522030
134SALL4_22934838_ChIP-ChIP_CD34+_Human0.81331102
135VDR_22108803_ChIP-Seq_LS180_Human0.79082674
136SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79010723
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77051514
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77010930
139ER_23166858_ChIP-Seq_MCF-7_Human0.76407636
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73050780
141RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72937019
142STAT4_19710469_ChIP-ChIP_TH1__Mouse0.72335239
143FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.71947357
144SOX2_16153702_ChIP-ChIP_HESCs_Human0.71705829
145ZFP57_27257070_Chip-Seq_ESCs_Mouse0.69609276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.29930645
2MP0010094_abnormal_chromosome_stability3.87837601
3MP0003693_abnormal_embryo_hatching3.78981513
4MP0008058_abnormal_DNA_repair3.34687324
5MP0004957_abnormal_blastocyst_morpholog3.31568540
6MP0003111_abnormal_nucleus_morphology3.18557368
7MP0003077_abnormal_cell_cycle3.03596208
8MP0008877_abnormal_DNA_methylation3.02724109
9MP0003950_abnormal_plasma_membrane2.77921730
10MP0008932_abnormal_embryonic_tissue2.59681926
11MP0003806_abnormal_nucleotide_metabolis2.56236038
12MP0000920_abnormal_myelination2.51685005
13MP0003787_abnormal_imprinting2.43497221
14MP0003718_maternal_effect2.43386917
15MP0008260_abnormal_autophagy2.32405316
16MP0009697_abnormal_copulation2.30848005
17MP0006072_abnormal_retinal_apoptosis2.23557242
18MP0006292_abnormal_olfactory_placode2.23431445
19MP0008007_abnormal_cellular_replicative2.21465315
20MP0000569_abnormal_digit_pigmentation2.16160323
21MP0002396_abnormal_hematopoietic_system2.00929715
22MP0003123_paternal_imprinting2.00414778
23MP0009333_abnormal_splenocyte_physiolog1.90100060
24MP0001529_abnormal_vocalization1.83696584
25MP0004147_increased_porphyrin_level1.77906185
26MP0005551_abnormal_eye_electrophysiolog1.69967072
27MP0001730_embryonic_growth_arrest1.68800374
28MP0001984_abnormal_olfaction1.64926687
29MP0005253_abnormal_eye_physiology1.59377928
30MP0002938_white_spotting1.57404734
31MP0005408_hypopigmentation1.56495755
32MP0008789_abnormal_olfactory_epithelium1.56213395
33MP0006035_abnormal_mitochondrial_morpho1.55429170
34MP0003195_calcinosis1.54639751
35MP0005671_abnormal_response_to1.53638468
36MP0001485_abnormal_pinna_reflex1.49417427
37MP0003763_abnormal_thymus_physiology1.49233065
38MP0005084_abnormal_gallbladder_morpholo1.48504335
39MP0000427_abnormal_hair_cycle1.48330348
40MP0002210_abnormal_sex_determination1.43781612
41MP0003786_premature_aging1.41702991
42MP0001929_abnormal_gametogenesis1.38127407
43MP0001835_abnormal_antigen_presentation1.37747262
44MP0000350_abnormal_cell_proliferation1.37097834
45MP0003890_abnormal_embryonic-extraembry1.34561935
46MP0008872_abnormal_physiological_respon1.33437271
47MP0001905_abnormal_dopamine_level1.30696841
48MP0001145_abnormal_male_reproductive1.30434185
49MP0005171_absent_coat_pigmentation1.25907469
50MP0004133_heterotaxia1.25894068
51MP0000372_irregular_coat_pigmentation1.23422793
52MP0005174_abnormal_tail_pigmentation1.21967777
53MP0001968_abnormal_touch/_nociception1.21581827
54MP0002736_abnormal_nociception_after1.20707257
55MP0001764_abnormal_homeostasis1.20469584
56MP0004742_abnormal_vestibular_system1.19638706
57MP0000653_abnormal_sex_gland1.19216822
58MP0002837_dystrophic_cardiac_calcinosis1.18603229
59MP0006054_spinal_hemorrhage1.16380315
60MP0003186_abnormal_redox_activity1.16027323
61MP0010386_abnormal_urinary_bladder1.15449356
62MP0002090_abnormal_vision1.14801163
63MP0005645_abnormal_hypothalamus_physiol1.12214823
64MP0000015_abnormal_ear_pigmentation1.12137621
65MP0005646_abnormal_pituitary_gland1.10076514
66MP0001661_extended_life_span1.10019949
67MP0000647_abnormal_sebaceous_gland1.08278902
68MP0005394_taste/olfaction_phenotype1.07778089
69MP0005499_abnormal_olfactory_system1.07778089
70MP0005410_abnormal_fertilization1.06057430
71MP0002638_abnormal_pupillary_reflex1.04621639
72MP0008875_abnormal_xenobiotic_pharmacok1.04591303
73MP0003136_yellow_coat_color1.02370940
74MP0006276_abnormal_autonomic_nervous1.01072543
75MP0004134_abnormal_chest_morphology1.00888704
76MP0001324_abnormal_eye_pigmentation0.99906304
77MP0000631_abnormal_neuroendocrine_gland0.98920245
78MP0001697_abnormal_embryo_size0.98869394
79MP0003656_abnormal_erythrocyte_physiolo0.98734127
80MP0002398_abnormal_bone_marrow0.98678237
81MP0003121_genomic_imprinting0.98540968
82MP0002234_abnormal_pharynx_morphology0.98128730
83MP0009785_altered_susceptibility_to0.97663249
84MP0005075_abnormal_melanosome_morpholog0.97607139
85MP0009046_muscle_twitch0.94464414
86MP0002160_abnormal_reproductive_system0.94211029
87MP0001293_anophthalmia0.94022802
88MP0000383_abnormal_hair_follicle0.93677191
89MP0006036_abnormal_mitochondrial_physio0.93642153
90MP0003698_abnormal_male_reproductive0.92316117
91MP0003880_abnormal_central_pattern0.92193297
92MP0005000_abnormal_immune_tolerance0.92125124
93MP0003632_abnormal_nervous_system0.91756070
94MP0003567_abnormal_fetal_cardiomyocyte0.90550038
95MP0002751_abnormal_autonomic_nervous0.89753038
96MP0000313_abnormal_cell_death0.89118990
97MP0001188_hyperpigmentation0.89073534
98MP0000716_abnormal_immune_system0.89064296
99MP0002019_abnormal_tumor_incidence0.88926404
100MP0003646_muscle_fatigue0.88844557
101MP0003119_abnormal_digestive_system0.86702082
102MP0002102_abnormal_ear_morphology0.86543586
103MP0000490_abnormal_crypts_of0.86345543
104MP0002723_abnormal_immune_serum0.86208242
105MP0002080_prenatal_lethality0.86066876
106MP0002420_abnormal_adaptive_immunity0.85655759
107MP0003937_abnormal_limbs/digits/tail_de0.85168118
108MP0002148_abnormal_hypersensitivity_rea0.85124430
109MP0001919_abnormal_reproductive_system0.84284167
110MP0002933_joint_inflammation0.83516699
111MP0001819_abnormal_immune_cell0.83317136
112MP0000689_abnormal_spleen_morphology0.83101724
113MP0001800_abnormal_humoral_immune0.83039683
114MP0002452_abnormal_antigen_presenting0.83016317
115MP0005389_reproductive_system_phenotype0.82555891
116MP0001986_abnormal_taste_sensitivity0.82315628
117MP0005391_vision/eye_phenotype0.81391328
118MP0002272_abnormal_nervous_system0.81205083
119MP0002429_abnormal_blood_cell0.80833746
120MP0008995_early_reproductive_senescence0.80577769
121MP0002722_abnormal_immune_system0.79994041
122MP0002163_abnormal_gland_morphology0.79875716
123MP0000703_abnormal_thymus_morphology0.79733293
124MP0005220_abnormal_exocrine_pancreas0.78760298
125MP0010307_abnormal_tumor_latency0.76237577
126MP0004381_abnormal_hair_follicle0.76076731
127MP0006082_CNS_inflammation0.75216188
128MP0004215_abnormal_myocardial_fiber0.74604453
129MP0005195_abnormal_posterior_eye0.73623510
130MP0002233_abnormal_nose_morphology0.73564334
131MP0005380_embryogenesis_phenotype0.72789420
132MP0001672_abnormal_embryogenesis/_devel0.72789420
133MP0009745_abnormal_behavioral_response0.72324382
134MP0002095_abnormal_skin_pigmentation0.70733809
135MP0002084_abnormal_developmental_patter0.69677721
136MP0001963_abnormal_hearing_physiology0.69149151
137MP0005085_abnormal_gallbladder_physiolo0.68770485
138MP0001286_abnormal_eye_development0.68594789
139MP0002229_neurodegeneration0.67654920
140MP0002928_abnormal_bile_duct0.67289979
141MP0002009_preneoplasia0.67248607
142MP0003221_abnormal_cardiomyocyte_apopto0.67179768
143MP0000358_abnormal_cell_content/0.67112309
144MP0001119_abnormal_female_reproductive0.67069901
145MP0005395_other_phenotype0.66706903
146MP0005025_abnormal_response_to0.66467626
147MP0004142_abnormal_muscle_tone0.65710576
148MP0005451_abnormal_body_composition0.65179366
149MP0002085_abnormal_embryonic_tissue0.64538097
150MP0003634_abnormal_glial_cell0.63583986
151MP0001243_abnormal_dermal_layer0.63399823
152MP0005310_abnormal_salivary_gland0.61967572

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.98582863
2Increased serum pyruvate (HP:0003542)4.98582863
3Cerebral hypomyelination (HP:0006808)4.69485135
4Birth length less than 3rd percentile (HP:0003561)4.27218361
5Irregular epiphyses (HP:0010582)3.87380070
6Gonadotropin excess (HP:0000837)3.82214904
7Pancreatic cysts (HP:0001737)3.45899833
8Breast hypoplasia (HP:0003187)3.45733482
9Abnormality of chromosome stability (HP:0003220)3.31458461
10Volvulus (HP:0002580)3.24159072
11Abnormality of the labia minora (HP:0012880)3.16985267
12Parakeratosis (HP:0001036)3.10621741
13Pancreatic fibrosis (HP:0100732)3.09712661
14Abnormality of midbrain morphology (HP:0002418)3.07354032
15Molar tooth sign on MRI (HP:0002419)3.07354032
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.05191840
17Degeneration of the lateral corticospinal tracts (HP:0002314)3.05191840
18CNS hypomyelination (HP:0003429)3.04670153
19Chromsome breakage (HP:0040012)3.03383869
20Absent epiphyses (HP:0010577)2.92865462
21Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.92865462
22Acute necrotizing encephalopathy (HP:0006965)2.92112868
23Small epiphyses (HP:0010585)2.86534314
24True hermaphroditism (HP:0010459)2.86173420
25Colon cancer (HP:0003003)2.83450801
263-Methylglutaconic aciduria (HP:0003535)2.82097611
27Postnatal microcephaly (HP:0005484)2.81598157
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.67196305
29Hypoplasia of the capital femoral epiphysis (HP:0003090)2.66497275
30Autoamputation (HP:0001218)2.60776490
31Hypoplastic pelvis (HP:0008839)2.60149880
32Mitochondrial inheritance (HP:0001427)2.58946996
33Increased CSF lactate (HP:0002490)2.51733218
34Abnormal mitochondria in muscle tissue (HP:0008316)2.49904577
35Methylmalonic acidemia (HP:0002912)2.48895609
36Leukodystrophy (HP:0002415)2.46649338
37Cerebral edema (HP:0002181)2.44998475
38Peripheral hypomyelination (HP:0007182)2.43903338
39Increased hepatocellular lipid droplets (HP:0006565)2.39318516
40Premature ovarian failure (HP:0008209)2.38997943
41Rough bone trabeculation (HP:0100670)2.38463287
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37247642
43Congenital stationary night blindness (HP:0007642)2.36927577
44Progressive macrocephaly (HP:0004481)2.35208131
45Aplastic anemia (HP:0001915)2.33008367
46Nephronophthisis (HP:0000090)2.30344283
47Chronic hepatic failure (HP:0100626)2.28356386
48Sensory axonal neuropathy (HP:0003390)2.28094067
49Increased serum lactate (HP:0002151)2.27707959
50Premature graying of hair (HP:0002216)2.26880047
51Abnormality of the preputium (HP:0100587)2.25965070
52Type I transferrin isoform profile (HP:0003642)2.25032070
53Congenital primary aphakia (HP:0007707)2.24527145
54Morphological abnormality of the inner ear (HP:0011390)2.23302796
55Hepatocellular necrosis (HP:0001404)2.22728997
56Secondary amenorrhea (HP:0000869)2.21748168
57Prolonged neonatal jaundice (HP:0006579)2.20725847
58Gait imbalance (HP:0002141)2.16064323
59Abnormality of the renal cortex (HP:0011035)2.14245366
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13845035
61Abnormality of alanine metabolism (HP:0010916)2.13845035
62Hyperalaninemia (HP:0003348)2.13845035
63Nephrogenic diabetes insipidus (HP:0009806)2.13355717
64Bone marrow hypocellularity (HP:0005528)2.12734421
65Methylmalonic aciduria (HP:0012120)2.11286635
66Renal Fanconi syndrome (HP:0001994)2.10941772
67Clubbing of toes (HP:0100760)2.10485879
68Renal cortical cysts (HP:0000803)2.07623647
69Duplicated collecting system (HP:0000081)2.07619098
70Abnormality of the renal collecting system (HP:0004742)2.07088901
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06812933
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06812933
73Hyperglycinemia (HP:0002154)2.04985772
74Bile duct proliferation (HP:0001408)2.04618370
75Abnormal biliary tract physiology (HP:0012439)2.04618370
76Abnormality of methionine metabolism (HP:0010901)2.03641477
77Hyperglycinuria (HP:0003108)2.03336369
78Severe combined immunodeficiency (HP:0004430)2.02698385
79Sclerocornea (HP:0000647)2.02323548
80Abnormality of the septum pellucidum (HP:0007375)2.02256115
81Adrenal hypoplasia (HP:0000835)2.00321440
82Aplasia/Hypoplasia of the tongue (HP:0010295)2.00098683
83Absent septum pellucidum (HP:0001331)1.99206504
84Acute encephalopathy (HP:0006846)1.99164386
85Lactic acidosis (HP:0003128)1.98613767
86Disinhibition (HP:0000734)1.98512894
87Alacrima (HP:0000522)1.97915655
88Abnormal number of erythroid precursors (HP:0012131)1.97773140
89Progressive inability to walk (HP:0002505)1.97141463
90Hepatosplenomegaly (HP:0001433)1.96927379
91Abnormality of cochlea (HP:0000375)1.96154011
92Meckel diverticulum (HP:0002245)1.96152127
93Abnormality of the renal medulla (HP:0100957)1.94718029
94Abnormality of the duodenum (HP:0002246)1.94673157
95Stenosis of the external auditory canal (HP:0000402)1.94313849
96Abnormality of the ileum (HP:0001549)1.93542704
97Menstrual irregularities (HP:0000858)1.92886056
98Abolished electroretinogram (ERG) (HP:0000550)1.91520239
99Resting tremor (HP:0002322)1.90996366
100Supernumerary spleens (HP:0009799)1.90842222
101Abnormality of B cell number (HP:0010975)1.90669793
102Sloping forehead (HP:0000340)1.90017601
103Abnormality of the pons (HP:0007361)1.90010316
104Abnormality of serum amino acid levels (HP:0003112)1.89187188
105Abnormality of glycine metabolism (HP:0010895)1.88633747
106Abnormality of serine family amino acid metabolism (HP:0010894)1.88633747
107Thyroiditis (HP:0100646)1.88338782
108Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87950916
109Genital tract atresia (HP:0001827)1.87839062
110Median cleft lip (HP:0000161)1.87640956
111Congenital, generalized hypertrichosis (HP:0004540)1.87611633
112Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86383778
113Hypoplasia of the pons (HP:0012110)1.86188783
114Abnormal lung lobation (HP:0002101)1.85788025
115Lipid accumulation in hepatocytes (HP:0006561)1.85420364
116Abnormality of chromosome segregation (HP:0002916)1.84881249
117Vaginal atresia (HP:0000148)1.84501746
118Preaxial hand polydactyly (HP:0001177)1.84472608
119Metaphyseal dysplasia (HP:0100255)1.83418329
120Carpal bone hypoplasia (HP:0001498)1.83332272
121Astigmatism (HP:0000483)1.83216745
122Abnormality of cells of the erythroid lineage (HP:0012130)1.83212261
123Abnormal trabecular bone morphology (HP:0100671)1.82043069
124Lethargy (HP:0001254)1.80663493
125Absent thumb (HP:0009777)1.80158873
126Abnormal spermatogenesis (HP:0008669)1.79538912
127Attenuation of retinal blood vessels (HP:0007843)1.79471113
128Hypothermia (HP:0002045)1.79208627
129T lymphocytopenia (HP:0005403)1.78953992
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.78883604
131Congenital ichthyosiform erythroderma (HP:0007431)1.78690184
132Abnormality of the phalanges of the 2nd finger (HP:0009541)1.78270434
133Abnormality of the corticospinal tract (HP:0002492)1.77576373
134Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77184250
135Medial flaring of the eyebrow (HP:0010747)1.76880307
136Male pseudohermaphroditism (HP:0000037)1.76695757
137Myelodysplasia (HP:0002863)1.76609151
138Optic disc pallor (HP:0000543)1.76106093
139Triphalangeal thumb (HP:0001199)1.76093952
140Anencephaly (HP:0002323)1.76058932
141Abnormality of the anterior horn cell (HP:0006802)1.75638867
142Degeneration of anterior horn cells (HP:0002398)1.75638867
143Small intestinal stenosis (HP:0012848)1.74823486
144Duodenal stenosis (HP:0100867)1.74823486
145Lymphoma (HP:0002665)1.74742741
146Postaxial foot polydactyly (HP:0001830)1.74409606
147Combined immunodeficiency (HP:0005387)1.74057687
148B lymphocytopenia (HP:0010976)1.73722414
149Type 2 muscle fiber atrophy (HP:0003554)1.72869505
150Microvesicular hepatic steatosis (HP:0001414)1.72689559
151Pancytopenia (HP:0001876)1.72527267
152Agnosia (HP:0010524)1.72106109
153Abnormal protein glycosylation (HP:0012346)1.71694988
154Abnormal glycosylation (HP:0012345)1.71694988
155Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71694988
156Abnormal protein N-linked glycosylation (HP:0012347)1.71694988
157Hepatic necrosis (HP:0002605)1.71323746
158Stomatitis (HP:0010280)1.70992880
159Pancreatic islet-cell hyperplasia (HP:0004510)1.70100426
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.70033865
161Genu varum (HP:0002970)1.69752022
162Ependymoma (HP:0002888)1.69598699
163Epiphyseal dysplasia (HP:0002656)1.68831973
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.68781238
165Abnormality of T cell number (HP:0011839)1.68237999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.92204039
2BUB13.87193333
3FRK3.85786129
4MST43.23572126
5EIF2AK32.85294195
6STK392.73570231
7CDC72.62749084
8PBK2.49993504
9TSSK62.46470912
10WEE12.41953485
11PLK42.26933000
12OXSR12.26462251
13SRPK12.24562059
14BCR2.11773076
15WNK32.11100287
16MKNK12.10061895
17BRSK22.06505323
18ADRBK22.01163651
19STK161.95791895
20VRK11.89970586
21TRIM281.85534982
22TAF11.80036748
23VRK21.69913723
24NEK11.57133981
25GRK11.54481554
26NEK61.46933035
27PLK31.46551473
28ACVR1B1.44901995
29MAP4K21.44516562
30MKNK21.42258173
31MET1.39983539
32TESK21.39406582
33INSRR1.34509634
34LIMK11.29064945
35CDK191.27618820
36IRAK41.26230968
37SCYL21.24770700
38PINK11.24299939
39AKT31.19937281
40TXK1.19839676
41ATR1.19011067
42PNCK1.17395813
43TNIK1.14333813
44CSNK1G31.11426086
45WNK41.11321312
46ZAK1.06970321
47PLK11.06035395
48CASK1.04430537
49MAP3K41.03864508
50TLK11.03236738
51ERBB41.03090836
52BMPR1B1.01197031
53RPS6KA41.00162275
54TTK0.99831622
55MAP3K140.99112801
56BMPR20.95983431
57MAP3K80.95941693
58CCNB10.95859388
59MAP3K120.94769421
60DYRK30.93125747
61MAPKAPK50.91971794
62DYRK20.90539137
63CHEK20.90122265
64TGFBR10.88259794
65BRAF0.88075233
66CAMK2B0.87333280
67CDK70.87086559
68CSNK1A1L0.83572827
69RPS6KA50.83096827
70MAPK130.82997908
71IKBKB0.82101375
72STK30.82076005
73BCKDK0.81849643
74MELK0.81343930
75AURKB0.81321212
76PDK20.81234777
77EIF2AK20.80292369
78BRSK10.77936877
79MAP3K130.74062331
80ERBB30.73267728
81CSNK1G10.72628309
82PDK30.72481068
83PDK40.72481068
84STK38L0.71401137
85PKN10.71080375
86TRPM70.70616162
87CHEK10.70289487
88NEK20.69576856
89PRPF4B0.68650268
90STK100.67060396
91NME10.65590579
92AURKA0.65432822
93PAK30.65281440
94PIM20.63512042
95TEC0.62589720
96MUSK0.60254309
97ADRBK10.57552374
98MAP2K70.57014057
99STK40.56716326
100PLK20.56575958
101NLK0.56270573
102PASK0.55756863
103CSNK2A20.55719638
104CSNK2A10.55222511
105PRKCE0.53264258
106PRKCG0.52893179
107ITK0.52754940
108CAMKK20.52414453
109ATM0.52102466
110NME20.50884647
111ROCK20.50594321
112RPS6KB10.50576288
113MAP4K10.50193567
114FGFR20.49117954
115BRD40.48213694
116TAOK30.47543782
117CAMK2D0.46482564
118FLT30.46394260
119CSNK1G20.44679882
120EPHB10.43622827
121FGR0.43169770
122CDK10.41258963
123NUAK10.40777776
124CLK10.40672024
125CDK140.40160853
126PRKCQ0.39065331
127PAK10.39029065
128CDK180.37736689
129CSNK1E0.37370371
130LCK0.36324316
131CDK150.35861218
132ARAF0.33712910
133MINK10.32223275
134PRKCI0.30688463
135CSNK1A10.30571470
136FER0.29209007
137GRK50.27370352
138GRK70.27128749
139PIM10.26968210

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.02633200
2RNA polymerase_Homo sapiens_hsa030203.74146868
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55129066
4DNA replication_Homo sapiens_hsa030303.32772152
5Mismatch repair_Homo sapiens_hsa034303.10511401
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.09858912
7Homologous recombination_Homo sapiens_hsa034402.82720653
8Protein export_Homo sapiens_hsa030602.62375412
9* RNA transport_Homo sapiens_hsa030132.58825952
10Non-homologous end-joining_Homo sapiens_hsa034502.56930878
11Basal transcription factors_Homo sapiens_hsa030222.44262608
12Spliceosome_Homo sapiens_hsa030402.43317213
13Nucleotide excision repair_Homo sapiens_hsa034202.31128947
14Propanoate metabolism_Homo sapiens_hsa006402.22160685
15Ribosome_Homo sapiens_hsa030102.11242075
16Cell cycle_Homo sapiens_hsa041102.04423958
17Vitamin B6 metabolism_Homo sapiens_hsa007502.01659810
18Pyrimidine metabolism_Homo sapiens_hsa002401.97943796
19Base excision repair_Homo sapiens_hsa034101.97212770
20Fanconi anemia pathway_Homo sapiens_hsa034601.89334773
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85878414
22RNA degradation_Homo sapiens_hsa030181.84296996
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84212384
24Steroid biosynthesis_Homo sapiens_hsa001001.82246323
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82226091
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77755133
27Oxidative phosphorylation_Homo sapiens_hsa001901.75044905
28Butanoate metabolism_Homo sapiens_hsa006501.56354405
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43816368
30Parkinsons disease_Homo sapiens_hsa050121.43801794
31Fatty acid elongation_Homo sapiens_hsa000621.42317433
32One carbon pool by folate_Homo sapiens_hsa006701.41394095
33Selenocompound metabolism_Homo sapiens_hsa004501.41245545
34Purine metabolism_Homo sapiens_hsa002301.40066134
35Phototransduction_Homo sapiens_hsa047441.28278016
36mRNA surveillance pathway_Homo sapiens_hsa030151.16888646
37Epstein-Barr virus infection_Homo sapiens_hsa051691.14838421
38Ether lipid metabolism_Homo sapiens_hsa005651.12740418
39Huntingtons disease_Homo sapiens_hsa050161.12414715
40Peroxisome_Homo sapiens_hsa041461.09876520
41Systemic lupus erythematosus_Homo sapiens_hsa053221.05250712
42Nitrogen metabolism_Homo sapiens_hsa009101.04027916
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03271952
44Caffeine metabolism_Homo sapiens_hsa002321.03095549
45Autoimmune thyroid disease_Homo sapiens_hsa053201.02382220
46Tryptophan metabolism_Homo sapiens_hsa003801.02192112
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02018758
48p53 signaling pathway_Homo sapiens_hsa041150.98961010
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98169808
50Graft-versus-host disease_Homo sapiens_hsa053320.92187701
51Allograft rejection_Homo sapiens_hsa053300.90407435
52Oocyte meiosis_Homo sapiens_hsa041140.90095284
53Pyruvate metabolism_Homo sapiens_hsa006200.85886526
54Viral carcinogenesis_Homo sapiens_hsa052030.84390799
55Primary immunodeficiency_Homo sapiens_hsa053400.82574242
56Alzheimers disease_Homo sapiens_hsa050100.82447250
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.78973865
58Sphingolipid metabolism_Homo sapiens_hsa006000.78009230
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75921585
60Nicotine addiction_Homo sapiens_hsa050330.70828659
61Rheumatoid arthritis_Homo sapiens_hsa053230.70504835
62Olfactory transduction_Homo sapiens_hsa047400.70139272
63Legionellosis_Homo sapiens_hsa051340.68976441
64Arachidonic acid metabolism_Homo sapiens_hsa005900.67258892
65Glutathione metabolism_Homo sapiens_hsa004800.66728818
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66440358
67Regulation of autophagy_Homo sapiens_hsa041400.65443895
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64878260
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.64831030
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64363641
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63625046
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.62581861
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61540387
74Herpes simplex infection_Homo sapiens_hsa051680.61203108
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.60879388
76Measles_Homo sapiens_hsa051620.60826820
77Fatty acid metabolism_Homo sapiens_hsa012120.59366452
78beta-Alanine metabolism_Homo sapiens_hsa004100.58208251
79Collecting duct acid secretion_Homo sapiens_hsa049660.58125063
80Cardiac muscle contraction_Homo sapiens_hsa042600.57491440
81Shigellosis_Homo sapiens_hsa051310.56724403
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55297525
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55105615
84Alcoholism_Homo sapiens_hsa050340.54927106
85Type I diabetes mellitus_Homo sapiens_hsa049400.54429579
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.54077140
87Antigen processing and presentation_Homo sapiens_hsa046120.53590133
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53243488
89Asthma_Homo sapiens_hsa053100.52036110
90Taste transduction_Homo sapiens_hsa047420.51990351
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51754652
92Retinol metabolism_Homo sapiens_hsa008300.50904122
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50450143
94Chemical carcinogenesis_Homo sapiens_hsa052040.50267731
95Fatty acid degradation_Homo sapiens_hsa000710.49568591
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48076229
97Hematopoietic cell lineage_Homo sapiens_hsa046400.47624148
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47449777
99Sulfur metabolism_Homo sapiens_hsa009200.46840817
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45812472
101Phagosome_Homo sapiens_hsa041450.43680742
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43550203
103Metabolic pathways_Homo sapiens_hsa011000.43022841
104Vibrio cholerae infection_Homo sapiens_hsa051100.42007682
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40814392
106Arginine and proline metabolism_Homo sapiens_hsa003300.39952465
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39528613
108Linoleic acid metabolism_Homo sapiens_hsa005910.39385622
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38553079
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.37313922
111Sulfur relay system_Homo sapiens_hsa041220.36581061
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35831327
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35540605
114T cell receptor signaling pathway_Homo sapiens_hsa046600.31725310
115Folate biosynthesis_Homo sapiens_hsa007900.30576344
116Malaria_Homo sapiens_hsa051440.30454497
117Pentose phosphate pathway_Homo sapiens_hsa000300.30018404
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28378733
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27099678
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26333468
121Lysine degradation_Homo sapiens_hsa003100.24303779
122HTLV-I infection_Homo sapiens_hsa051660.22390187
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22214610
124Vitamin digestion and absorption_Homo sapiens_hsa049770.20459689
125TGF-beta signaling pathway_Homo sapiens_hsa043500.18671922
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18240941
127Carbon metabolism_Homo sapiens_hsa012000.17896630
128Tyrosine metabolism_Homo sapiens_hsa003500.16953549
129Prostate cancer_Homo sapiens_hsa052150.16857119
130Apoptosis_Homo sapiens_hsa042100.14823265
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14677724
132Hepatitis B_Homo sapiens_hsa051610.14014540
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13595397
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12154933
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10628042
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10416158
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.10146505
138N-Glycan biosynthesis_Homo sapiens_hsa005100.09672469
139Biosynthesis of amino acids_Homo sapiens_hsa012300.08748565
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.08645463
141Renal cell carcinoma_Homo sapiens_hsa052110.07404568
142Salmonella infection_Homo sapiens_hsa051320.07196968

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »