TRO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.82761614
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.15968695
3synaptic vesicle maturation (GO:0016188)5.62858448
4vocalization behavior (GO:0071625)5.59461261
5locomotory exploration behavior (GO:0035641)5.47679236
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.41473111
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.37867040
8nucleobase catabolic process (GO:0046113)5.33458080
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.32912242
10synaptic vesicle exocytosis (GO:0016079)5.16916739
11neuron cell-cell adhesion (GO:0007158)5.04374118
12regulation of glutamate receptor signaling pathway (GO:1900449)5.04091459
13regulation of synaptic vesicle exocytosis (GO:2000300)4.90162576
14protein localization to synapse (GO:0035418)4.86306826
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.74345559
16glutamate secretion (GO:0014047)4.71219858
17layer formation in cerebral cortex (GO:0021819)4.57058325
18neurotransmitter secretion (GO:0007269)4.55887520
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.55177430
20exploration behavior (GO:0035640)4.50133942
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.37865828
22regulation of synaptic vesicle transport (GO:1902803)4.35989188
23establishment of mitochondrion localization (GO:0051654)4.31764325
24synaptic transmission, glutamatergic (GO:0035249)4.22364841
25regulation of neuronal synaptic plasticity (GO:0048168)4.20395546
26glutamate receptor signaling pathway (GO:0007215)4.15501155
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.15047474
28regulation of synapse structural plasticity (GO:0051823)4.14013431
29dendritic spine morphogenesis (GO:0060997)4.12349328
30gamma-aminobutyric acid transport (GO:0015812)4.09578013
31neuronal action potential propagation (GO:0019227)4.09468743
32neuron-neuron synaptic transmission (GO:0007270)4.03166323
33neurotransmitter-gated ion channel clustering (GO:0072578)4.02807461
34neuron recognition (GO:0008038)4.02806319
35proline transport (GO:0015824)4.01484632
36positive regulation of synaptic transmission, GABAergic (GO:0032230)3.92096709
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.88017743
38retinal ganglion cell axon guidance (GO:0031290)3.81850197
39long-term memory (GO:0007616)3.79062414
40axonal fasciculation (GO:0007413)3.77425207
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76192482
42transmission of nerve impulse (GO:0019226)3.74023893
43neurotransmitter transport (GO:0006836)3.73573953
44postsynaptic membrane organization (GO:0001941)3.63339650
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.62630601
46positive regulation of synapse maturation (GO:0090129)3.60796488
47positive regulation of membrane potential (GO:0045838)3.60485467
48regulation of postsynaptic membrane potential (GO:0060078)3.52053831
49activation of protein kinase A activity (GO:0034199)3.51046728
50cerebellar Purkinje cell differentiation (GO:0021702)3.46302282
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.44440052
52cell migration in hindbrain (GO:0021535)3.43591075
53regulation of neurotransmitter levels (GO:0001505)3.42926942
54regulation of dendritic spine morphogenesis (GO:0061001)3.41831223
55prepulse inhibition (GO:0060134)3.41521439
56synaptic vesicle endocytosis (GO:0048488)3.41107192
57dendrite morphogenesis (GO:0048813)3.40985022
58auditory behavior (GO:0031223)3.40452943
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.38926000
60positive regulation of mitochondrial fission (GO:0090141)3.35203630
61neuromuscular process controlling balance (GO:0050885)3.34573948
62calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.33632786
63regulation of neurotransmitter secretion (GO:0046928)3.32419337
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.32183956
65cellular potassium ion homeostasis (GO:0030007)3.31844317
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29866659
67neuromuscular process controlling posture (GO:0050884)3.29624702
68regulation of synaptic plasticity (GO:0048167)3.29257899
69response to pheromone (GO:0019236)3.28549492
70presynaptic membrane assembly (GO:0097105)3.27122246
71synapse assembly (GO:0007416)3.23302878
72regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22844866
73response to auditory stimulus (GO:0010996)3.22770347
74response to histamine (GO:0034776)3.22742661
75membrane depolarization during action potential (GO:0086010)3.22654936
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22341451
77membrane hyperpolarization (GO:0060081)3.22064084
78establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.21710808
79mitochondrion transport along microtubule (GO:0047497)3.21710808
80neuronal ion channel clustering (GO:0045161)3.20589979
81regulation of vesicle fusion (GO:0031338)3.19939019
82C4-dicarboxylate transport (GO:0015740)3.18435205
83long-term synaptic potentiation (GO:0060291)3.17626348
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.17376931
85vesicle transport along microtubule (GO:0047496)3.17159890
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16678279
87behavioral fear response (GO:0001662)3.15269635
88behavioral defense response (GO:0002209)3.15269635
89membrane depolarization (GO:0051899)3.12480510
90negative regulation of synaptic transmission, GABAergic (GO:0032229)3.11501618
91regulation of neurotransmitter transport (GO:0051588)3.10862194
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10295007
93presynaptic membrane organization (GO:0097090)3.09607869
94sodium ion export (GO:0071436)3.09218639
95central nervous system projection neuron axonogenesis (GO:0021952)3.07425621
96positive regulation of neurotransmitter transport (GO:0051590)3.07398797
97cell communication by electrical coupling (GO:0010644)3.07190115
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05661818
99intraspecies interaction between organisms (GO:0051703)3.03949079
100social behavior (GO:0035176)3.03949079
101learning (GO:0007612)3.03775143
102regulation of synaptic transmission, GABAergic (GO:0032228)3.03580931
103mating behavior (GO:0007617)3.02716823
104protein localization to cilium (GO:0061512)3.02215773
105nonmotile primary cilium assembly (GO:0035058)3.01358285
106positive regulation of synapse assembly (GO:0051965)3.00681577
107synapse organization (GO:0050808)2.99908854
108glycine transport (GO:0015816)2.97623436
109positive regulation of neurotransmitter secretion (GO:0001956)2.97521469
110regulation of glutamate secretion (GO:0014048)2.96999210
111synaptic transmission (GO:0007268)2.96545852
112behavioral response to nicotine (GO:0035095)2.96460489
113dopamine receptor signaling pathway (GO:0007212)2.96368366
114innervation (GO:0060384)2.95867822
115negative regulation of oligodendrocyte differentiation (GO:0048715)2.94929511
116cerebral cortex radially oriented cell migration (GO:0021799)2.89529872
117head development (GO:0060322)2.89153575
118mechanosensory behavior (GO:0007638)2.84483067
119spinal cord development (GO:0021510)2.83525804
120olfactory bulb development (GO:0021772)2.81606033
121hippocampus development (GO:0021766)2.81099929
122limb bud formation (GO:0060174)2.79301881
123behavioral response to ethanol (GO:0048149)2.73526978
124regulation of synapse assembly (GO:0051963)2.68891872
125axon extension (GO:0048675)2.67478145
126somite development (GO:0061053)2.66813430
127neuromuscular synaptic transmission (GO:0007274)2.64526318
128regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.63159318
129short-term memory (GO:0007614)2.62660817
130regulation of development, heterochronic (GO:0040034)2.56048929
131central nervous system neuron axonogenesis (GO:0021955)2.55887402
132regulation of feeding behavior (GO:0060259)2.54766729
133dendritic spine organization (GO:0097061)2.53911042
134protein polyglutamylation (GO:0018095)2.53240913
135regulation of respiratory system process (GO:0044065)2.50145615
136glycosphingolipid biosynthetic process (GO:0006688)2.50061067
137* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.49063952
138axon extension involved in axon guidance (GO:0048846)2.48679114
139neuron projection extension involved in neuron projection guidance (GO:1902284)2.48679114
140startle response (GO:0001964)2.45472277
141appendage development (GO:0048736)2.45365606
142limb development (GO:0060173)2.45365606
143mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.43117091
144positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.43117091
145intraciliary transport (GO:0042073)2.42750747
146heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.37728647
147adult walking behavior (GO:0007628)2.35450112
148axonogenesis (GO:0007409)2.33528650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.40685126
2GBX2_23144817_ChIP-Seq_PC3_Human3.56800770
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14881338
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11049821
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04551456
6REST_21632747_ChIP-Seq_MESCs_Mouse2.84712970
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71308840
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71308840
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70210650
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.68080592
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59915689
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.57876793
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54460311
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.54270579
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.54201902
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.49966181
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49842757
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45800333
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45232834
20DROSHA_22980978_ChIP-Seq_HELA_Human2.44015445
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.37457598
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.33211936
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.27827875
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25067593
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23854882
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.18508663
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15277740
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12940783
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01357865
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95041700
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87617818
32TAF15_26573619_Chip-Seq_HEK293_Human1.80679039
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79552848
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73288335
35AR_21572438_ChIP-Seq_LNCaP_Human1.72654044
36SMAD4_21799915_ChIP-Seq_A2780_Human1.65480219
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.63826170
38ZNF274_21170338_ChIP-Seq_K562_Hela1.62570483
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61929576
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60208629
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.50117549
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.49381425
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47306245
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46572764
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46268452
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43452752
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42629021
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40048582
49P300_19829295_ChIP-Seq_ESCs_Human1.39795408
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.38291678
51EWS_26573619_Chip-Seq_HEK293_Human1.37784462
52FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.37139345
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37061528
54VDR_22108803_ChIP-Seq_LS180_Human1.35911899
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.34752498
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.34413793
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34253370
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31877807
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.31068993
60RNF2_27304074_Chip-Seq_NSC_Mouse1.29834072
61IGF1R_20145208_ChIP-Seq_DFB_Human1.26905499
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26829703
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24476176
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23688988
65AR_19668381_ChIP-Seq_PC3_Human1.22255190
66AR_25329375_ChIP-Seq_VCAP_Human1.21226509
67STAT3_23295773_ChIP-Seq_U87_Human1.19425191
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18303885
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.18172765
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17902903
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17198749
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15422319
73CBP_20019798_ChIP-Seq_JUKART_Human1.15415262
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15415262
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15135248
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14572108
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14508235
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14278451
79FUS_26573619_Chip-Seq_HEK293_Human1.13262228
80SOX9_26525672_Chip-Seq_HEART_Mouse1.12506483
81IRF1_19129219_ChIP-ChIP_H3396_Human1.08631956
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.07757461
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07755941
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07553590
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07030941
86TCF4_23295773_ChIP-Seq_U87_Human1.06372787
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.06290120
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05392411
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05348439
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04820533
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04800964
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03091420
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02783866
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01963745
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01674096
96RUNX2_22187159_ChIP-Seq_PCA_Human1.00234757
97POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99406128
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.98602196
99* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97839745
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97793416
101POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96910555
102SMAD3_21741376_ChIP-Seq_ESCs_Human0.96395548
103EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96385299
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94819194
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94740514
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94719761
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94228661
108AHR_22903824_ChIP-Seq_MCF-7_Human0.93938248
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93184822
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93057129
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92690718
112KDM2B_26808549_Chip-Seq_K562_Human0.92679412
113GATA1_26923725_Chip-Seq_HPCs_Mouse0.92473879
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92074645
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91961123
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91521828
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.91156535
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91050111
119E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90589760
120TP63_19390658_ChIP-ChIP_HaCaT_Human0.90199917
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89913253
122ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89847251
123JUN_21703547_ChIP-Seq_K562_Human0.89648968
124TAL1_26923725_Chip-Seq_HPCs_Mouse0.88967090
125TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88893141
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.88652806
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88504060
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88504060
129ER_23166858_ChIP-Seq_MCF-7_Human0.86301570
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86035101
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85170603
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82700438

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.84840533
2MP0003880_abnormal_central_pattern4.86220566
3MP0003635_abnormal_synaptic_transmissio3.99321878
4MP0004270_analgesia3.38293286
5MP0009745_abnormal_behavioral_response3.31407395
6MP0002063_abnormal_learning/memory/cond3.19523369
7MP0005423_abnormal_somatic_nervous3.12206656
8MP0001968_abnormal_touch/_nociception3.10507015
9MP0002064_seizures3.05592341
10MP0009046_muscle_twitch3.04242796
11MP0002822_catalepsy2.86170265
12MP0002572_abnormal_emotion/affect_behav2.70863964
13MP0002734_abnormal_mechanical_nocicepti2.62755197
14MP0002272_abnormal_nervous_system2.46288567
15MP0001486_abnormal_startle_reflex2.41806301
16MP0003122_maternal_imprinting2.37713369
17MP0002736_abnormal_nociception_after2.34466794
18MP0002735_abnormal_chemical_nociception2.27867082
19MP0006276_abnormal_autonomic_nervous2.15410314
20MP0002102_abnormal_ear_morphology2.13437105
21MP0002733_abnormal_thermal_nociception2.11967146
22MP0001440_abnormal_grooming_behavior2.11093122
23MP0001501_abnormal_sleep_pattern2.09650344
24MP0003787_abnormal_imprinting2.03583990
25MP0000778_abnormal_nervous_system2.00448972
26MP0002067_abnormal_sensory_capabilities1.96136502
27MP0001970_abnormal_pain_threshold1.95893707
28MP0002184_abnormal_innervation1.95817052
29MP0002653_abnormal_ependyma_morphology1.87225135
30MP0002557_abnormal_social/conspecific_i1.81551493
31MP0004811_abnormal_neuron_physiology1.75942254
32MP0005386_behavior/neurological_phenoty1.75438679
33MP0004924_abnormal_behavior1.75438679
34MP0000049_abnormal_middle_ear1.72438733
35MP0008789_abnormal_olfactory_epithelium1.72180078
36MP0005645_abnormal_hypothalamus_physiol1.69765545
37MP0004858_abnormal_nervous_system1.66667034
38MP0005646_abnormal_pituitary_gland1.66249829
39MP0009780_abnormal_chondrocyte_physiolo1.66110564
40MP0001529_abnormal_vocalization1.61264098
41MP0008569_lethality_at_weaning1.60595106
42MP0000955_abnormal_spinal_cord1.60202375
43MP0002909_abnormal_adrenal_gland1.55740694
44MP0004133_heterotaxia1.50147500
45MP0001984_abnormal_olfaction1.49631063
46MP0002882_abnormal_neuron_morphology1.44058129
47MP0005253_abnormal_eye_physiology1.43594455
48MP0003329_amyloid_beta_deposits1.43486603
49MP0002066_abnormal_motor_capabilities/c1.39019474
50MP0000566_synostosis1.35131831
51MP0004885_abnormal_endolymph1.33483028
52MP0004142_abnormal_muscle_tone1.32426405
53MP0003119_abnormal_digestive_system1.31713149
54MP0003136_yellow_coat_color1.30911721
55MP0003121_genomic_imprinting1.28111040
56MP0001293_anophthalmia1.25832733
57MP0003879_abnormal_hair_cell1.24501246
58MP0003011_delayed_dark_adaptation1.23714032
59MP0001905_abnormal_dopamine_level1.23071891
60MP0003123_paternal_imprinting1.22812206
61MP0003938_abnormal_ear_development1.21947103
62MP0002152_abnormal_brain_morphology1.21034122
63MP0001502_abnormal_circadian_rhythm1.18579137
64MP0002938_white_spotting1.17693223
65MP0000569_abnormal_digit_pigmentation1.17124952
66MP0003633_abnormal_nervous_system1.14783346
67MP0000751_myopathy1.13694132
68MP0002233_abnormal_nose_morphology1.13221522
69MP0002234_abnormal_pharynx_morphology1.11593081
70MP0001188_hyperpigmentation1.11410801
71MP0003567_abnormal_fetal_cardiomyocyte1.10884806
72MP0010030_abnormal_orbit_morphology1.10083940
73MP0003937_abnormal_limbs/digits/tail_de1.09315892
74MP0003283_abnormal_digestive_organ1.08781486
75MP0003385_abnormal_body_wall1.06572170
76MP0000026_abnormal_inner_ear1.05487326
77MP0003890_abnormal_embryonic-extraembry1.01478465
78MP0003631_nervous_system_phenotype1.00034092
79MP0000631_abnormal_neuroendocrine_gland0.99706687
80MP0005391_vision/eye_phenotype0.98516713
81MP0005394_taste/olfaction_phenotype0.97786565
82MP0005499_abnormal_olfactory_system0.97786565
83MP0003755_abnormal_palate_morphology0.94774774
84MP0002069_abnormal_eating/drinking_beha0.92894515
85MP0003942_abnormal_urinary_system0.91453884
86MP0008872_abnormal_physiological_respon0.90825016
87MP0004145_abnormal_muscle_electrophysio0.90758448
88MP0005195_abnormal_posterior_eye0.90713620
89MP0002638_abnormal_pupillary_reflex0.90272710
90MP0000013_abnormal_adipose_tissue0.90063060
91MP0002229_neurodegeneration0.88531371
92MP0005551_abnormal_eye_electrophysiolog0.88128599
93MP0002249_abnormal_larynx_morphology0.87575389
94MP0004085_abnormal_heartbeat0.87342381
95MP0010386_abnormal_urinary_bladder0.87264823
96MP0001177_atelectasis0.86447976
97MP0001286_abnormal_eye_development0.85943802
98MP0002697_abnormal_eye_size0.85203275
99MP0000534_abnormal_ureter_morphology0.84833979
100MP0001986_abnormal_taste_sensitivity0.84169091
101MP0004742_abnormal_vestibular_system0.84168354
102MP0002752_abnormal_somatic_nervous0.83706785
103MP0005171_absent_coat_pigmentation0.78723389
104MP0003861_abnormal_nervous_system0.77263487
105MP0003634_abnormal_glial_cell0.77150646
106MP0002081_perinatal_lethality0.76554473
107MP0001963_abnormal_hearing_physiology0.74741512
108MP0005084_abnormal_gallbladder_morpholo0.74572066
109MP0005623_abnormal_meninges_morphology0.74058838
110MP0003632_abnormal_nervous_system0.74023987
111MP0003137_abnormal_impulse_conducting0.73228271
112MP0002116_abnormal_craniofacial_bone0.72410428
113MP0003935_abnormal_craniofacial_develop0.72040304
114MP0008874_decreased_physiological_sensi0.69798962
115MP0002837_dystrophic_cardiac_calcinosis0.68609602
116MP0004233_abnormal_muscle_weight0.67347679
117MP0006072_abnormal_retinal_apoptosis0.66268344
118MP0003690_abnormal_glial_cell0.65346269
119MP0001299_abnormal_eye_distance/0.65264246
120MP0001943_abnormal_respiration0.64509709
121MP0005535_abnormal_body_temperature0.64378392
122MP0008961_abnormal_basal_metabolism0.64131039
123MP0006292_abnormal_olfactory_placode0.63966836
124MP0005167_abnormal_blood-brain_barrier0.62827578
125MP0004215_abnormal_myocardial_fiber0.62217739
126MP0005187_abnormal_penis_morphology0.61984741
127MP0002082_postnatal_lethality0.59469220
128MP0010770_preweaning_lethality0.59469220
129MP0010769_abnormal_survival0.58952009
130MP0002751_abnormal_autonomic_nervous0.58074715
131MP0001664_abnormal_digestion0.57999381
132MP0002090_abnormal_vision0.57613681
133MP0010768_mortality/aging0.55493083
134MP0001485_abnormal_pinna_reflex0.54788886
135MP0008877_abnormal_DNA_methylation0.53958858

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.01867339
2Myokymia (HP:0002411)6.38641811
3Focal seizures (HP:0007359)5.46330446
4Visual hallucinations (HP:0002367)4.75936201
5Epileptic encephalopathy (HP:0200134)4.33917393
6Atonic seizures (HP:0010819)4.33665683
7Febrile seizures (HP:0002373)4.17488762
8Progressive cerebellar ataxia (HP:0002073)4.12866440
9Absence seizures (HP:0002121)3.90467766
10Generalized tonic-clonic seizures (HP:0002069)3.59989322
11Dialeptic seizures (HP:0011146)3.55471781
12Ankle clonus (HP:0011448)3.47631542
13Action tremor (HP:0002345)3.42166976
14Broad-based gait (HP:0002136)3.38313830
15Impaired vibration sensation in the lower limbs (HP:0002166)3.33677919
16Supranuclear gaze palsy (HP:0000605)3.29685356
17Lissencephaly (HP:0001339)3.14271656
18Mutism (HP:0002300)3.05648137
19Retinal dysplasia (HP:0007973)3.01607481
20Poor eye contact (HP:0000817)3.01301569
21Urinary bladder sphincter dysfunction (HP:0002839)3.01111574
22Depression (HP:0000716)3.00697333
23Medial flaring of the eyebrow (HP:0010747)3.00137677
24Nephrogenic diabetes insipidus (HP:0009806)2.99394883
25Congenital primary aphakia (HP:0007707)2.97366114
26Abnormal eating behavior (HP:0100738)2.97003335
27Dysdiadochokinesis (HP:0002075)2.94704546
28Hyperventilation (HP:0002883)2.93330483
29Truncal ataxia (HP:0002078)2.91920548
30Gaze-evoked nystagmus (HP:0000640)2.88974854
31Anxiety (HP:0000739)2.87110416
32Drooling (HP:0002307)2.86246508
33Excessive salivation (HP:0003781)2.86246508
34Vaginal atresia (HP:0000148)2.85692607
35Genital tract atresia (HP:0001827)2.83170775
36Amblyopia (HP:0000646)2.78611258
37Limb dystonia (HP:0002451)2.77060318
38Progressive inability to walk (HP:0002505)2.77032590
39Impaired social interactions (HP:0000735)2.74124170
40Abnormal social behavior (HP:0012433)2.74124170
41Abnormality of the lower motor neuron (HP:0002366)2.70587079
42Cortical dysplasia (HP:0002539)2.67662136
43Urinary urgency (HP:0000012)2.67593916
44Type II lissencephaly (HP:0007260)2.67498593
45Hemiparesis (HP:0001269)2.66164258
46Postural instability (HP:0002172)2.64435485
47Polyphagia (HP:0002591)2.64048925
48Dysmetria (HP:0001310)2.63807136
49Spastic gait (HP:0002064)2.57770231
50Genetic anticipation (HP:0003743)2.57421554
51Termporal pattern (HP:0011008)2.53661965
52Insidious onset (HP:0003587)2.53661965
53Abnormality of the corticospinal tract (HP:0002492)2.48302235
54Pachygyria (HP:0001302)2.47197618
55Papilledema (HP:0001085)2.42981688
56Torticollis (HP:0000473)2.42810438
57True hermaphroditism (HP:0010459)2.41523058
58Pancreatic cysts (HP:0001737)2.40940873
59Impaired smooth pursuit (HP:0007772)2.40039522
60Pancreatic fibrosis (HP:0100732)2.37310560
61Pheochromocytoma (HP:0002666)2.36584122
62Scanning speech (HP:0002168)2.33032788
63Bradykinesia (HP:0002067)2.31184719
64Hemiplegia (HP:0002301)2.28553045
65Epileptiform EEG discharges (HP:0011182)2.27756180
66Agitation (HP:0000713)2.26370094
67Focal dystonia (HP:0004373)2.26273741
68Occipital encephalocele (HP:0002085)2.25570277
69Nephronophthisis (HP:0000090)2.23468735
70Abnormality of binocular vision (HP:0011514)2.23323468
71Diplopia (HP:0000651)2.23323468
72Cutaneous finger syndactyly (HP:0010554)2.22581871
73EEG with generalized epileptiform discharges (HP:0011198)2.22090851
74Amyotrophic lateral sclerosis (HP:0007354)2.21022821
75Failure to thrive in infancy (HP:0001531)2.20491855
76Lower limb muscle weakness (HP:0007340)2.19005651
77Hepatoblastoma (HP:0002884)2.16629126
78Fetal akinesia sequence (HP:0001989)2.15680231
79Split foot (HP:0001839)2.15331824
80Short 4th metacarpal (HP:0010044)2.15312780
81Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15312780
82Abnormality of ocular smooth pursuit (HP:0000617)2.14831080
83Colon cancer (HP:0003003)2.14574092
84Stereotypic behavior (HP:0000733)2.14530329
85Optic nerve hypoplasia (HP:0000609)2.14203307
86Hypsarrhythmia (HP:0002521)2.14066754
87Broad alveolar ridges (HP:0000187)2.13085384
88Poor coordination (HP:0002370)2.11792027
89Absent speech (HP:0001344)2.11535777
90Insomnia (HP:0100785)2.10147778
91Neuroendocrine neoplasm (HP:0100634)2.08751760
92Cerebral inclusion bodies (HP:0100314)2.06196522
93Craniofacial dystonia (HP:0012179)2.04442509
94Pointed chin (HP:0000307)2.04111779
95Septo-optic dysplasia (HP:0100842)2.03755772
96Impaired vibratory sensation (HP:0002495)2.02732070
97Renal hypoplasia (HP:0000089)2.02385826
98Postaxial hand polydactyly (HP:0001162)1.98799111
99Cerebellar dysplasia (HP:0007033)1.98752382
100Intention tremor (HP:0002080)1.98715852
101Oligodactyly (hands) (HP:0001180)1.98523780
102Specific learning disability (HP:0001328)1.98437846
103Anophthalmia (HP:0000528)1.98398199
104Cutaneous syndactyly (HP:0012725)1.97896725
105Hypoventilation (HP:0002791)1.97633020
106Vitreoretinal degeneration (HP:0000655)1.97032055
107Megalencephaly (HP:0001355)1.96929022
108Neurofibrillary tangles (HP:0002185)1.96687403
109Ventricular fibrillation (HP:0001663)1.96345649
110Spastic tetraplegia (HP:0002510)1.96171449
111Inability to walk (HP:0002540)1.94523744
112Broad foot (HP:0001769)1.94182374
113Abnormality of the 4th metacarpal (HP:0010012)1.93262806
114Dysmetric saccades (HP:0000641)1.93122342
115Incomplete penetrance (HP:0003829)1.92707883
116Morphological abnormality of the middle ear (HP:0008609)1.92334784
117Gait imbalance (HP:0002141)1.91589221
118Esotropia (HP:0000565)1.91278377
119Abnormality of midbrain morphology (HP:0002418)1.91210760
120Molar tooth sign on MRI (HP:0002419)1.91210760
121Hypoplasia of the brainstem (HP:0002365)1.91120029
122Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91120029
123Anterior segment dysgenesis (HP:0007700)1.90975132
124Status epilepticus (HP:0002133)1.90893327
125Hypoplastic pelvis (HP:0008839)1.89502667
126Intestinal atresia (HP:0011100)1.88620758
127Narrow forehead (HP:0000341)1.88572162
128Abnormality of salivation (HP:0100755)1.86486358
129Short foot (HP:0001773)1.86074758
130Protruding tongue (HP:0010808)1.85080740
131Abnormality of the labia minora (HP:0012880)1.83551397
132Generalized myoclonic seizures (HP:0002123)1.80930844
133Micropenis (HP:0000054)1.80715985
134Psychosis (HP:0000709)1.80302456
135Neuronal loss in central nervous system (HP:0002529)1.79013454
136Inappropriate behavior (HP:0000719)1.78879770
137Hypoplasia of the corpus callosum (HP:0002079)1.78760458
138Clonus (HP:0002169)1.78417329
139Decreased testicular size (HP:0008734)1.77656059
140Abnormal EKG (HP:0003115)1.77043736
141Neoplasm of the heart (HP:0100544)1.76849383
142Resting tremor (HP:0002322)1.76655242
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76654094
144Humeroradial synostosis (HP:0003041)1.75879485
145Synostosis involving the elbow (HP:0003938)1.75879485
146Annular pancreas (HP:0001734)1.75023907
147Gait ataxia (HP:0002066)1.74967717
148Sleep apnea (HP:0010535)1.74279922
149Hyperthyroidism (HP:0000836)1.73500927
150Blue irides (HP:0000635)1.72956669
151Bifid tongue (HP:0010297)1.72173461
152Postaxial foot polydactyly (HP:0001830)1.71577045
153Hyperglycinemia (HP:0002154)1.71474214
154Anencephaly (HP:0002323)1.69326353
155Oligodactyly (HP:0012165)1.67455347
156Short tibia (HP:0005736)1.67014026
157Cystic liver disease (HP:0006706)1.66838599
158Abnormality of the renal medulla (HP:0100957)1.65514690
159Aplasia/Hypoplasia of the lens (HP:0008063)1.65338471
160Morphological abnormality of the pyramidal tract (HP:0002062)1.65036317
161Rimmed vacuoles (HP:0003805)1.64149211
162Polymicrogyria (HP:0002126)1.63010796
163Fibular aplasia (HP:0002990)1.61324052
164Atrophy/Degeneration involving motor neurons (HP:0007373)1.61171117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.71920045
2MARK14.02158916
3MAP3K93.82610421
4EPHA43.69127200
5MAP3K43.19214825
6MINK12.76260186
7MAP2K72.60834438
8NTRK22.59462469
9MAP4K22.49937547
10CASK2.25029217
11TRIM282.22282879
12MAP3K122.19716360
13DAPK22.10063797
14PAK62.04675107
15TNIK2.04153618
16MAP2K41.92256131
17KSR21.90127328
18PNCK1.78259493
19MAPK131.75638981
20KSR11.70401789
21NTRK11.66972700
22SRPK11.64893725
23PRKD31.61297342
24CAMKK11.49930462
25CDK51.49546433
26CSNK1A1L1.44951790
27SIK21.42164803
28PLK21.41745613
29EPHA31.32083651
30GRK51.32047058
31DAPK11.31889302
32UHMK11.30925737
33CSNK1G11.29092466
34DYRK31.24156994
35LATS21.23083224
36ARAF1.21414203
37STK381.19732910
38PRKCG1.19037900
39PHKG11.18576198
40PHKG21.18576198
41PRPF4B1.18223159
42EPHB21.15064491
43TYRO31.13629625
44NUAK11.11929509
45BCKDK1.08686292
46LATS11.08098325
47FES1.07021444
48CDK191.01669178
49RIPK40.99111679
50INSRR0.98785519
51CDK180.94326215
52CAMK2A0.94215499
53MAP3K20.93592006
54CDK150.91974918
55SGK2230.91167078
56SGK4940.91167078
57CDK140.90986875
58BMPR1B0.90454653
59CSNK1G20.85802166
60PAK30.82246717
61STK110.80469196
62PKN10.80201489
63CDK11A0.79654261
64CAMKK20.78956792
65DYRK1B0.77030496
66CAMK10.76941258
67WNK30.76189721
68SGK20.75680014
69PRKCH0.73628112
70DYRK1A0.73246398
71RET0.72589002
72TAOK10.72201543
73MAP3K130.71957318
74MARK20.71644292
75CAMK2B0.71570058
76ALK0.70025449
77LMTK20.68093622
78GRK10.66736930
79ZAK0.65826379
80STK38L0.65353201
81SGK10.63194323
82CDC42BPA0.62009543
83MKNK10.60511142
84TIE10.60231731
85RAF10.60160579
86ERBB30.59887622
87FRK0.58431795
88SGK30.58352099
89SCYL20.57434770
90RPS6KA40.57180256
91AKT30.55363356
92ADRBK20.55160705
93OBSCN0.54799234
94OXSR10.54116460
95VRK10.53453229
96FER0.53138042
97BCR0.52937489
98CAMK1G0.52475435
99PTK2B0.52444382
100LIMK10.51439782
101MKNK20.49858366
102RPS6KA30.49428567
103PRKCZ0.49330361
104PRKCE0.48657093
105CSNK1A10.48541090
106PRKAA10.47214695
107TNK20.47042596
108TSSK60.46904754
109RPS6KA20.46599405
110PINK10.45805304
111MAPK100.45621202
112CSNK1D0.45243669
113NME10.45126852
114CSNK1G30.44539449
115PRKACA0.42872281
116NEK10.41648320
117CAMK40.41294333
118CCNB10.41165560
119PRKACB0.40485254
120FYN0.40276437
121CDK30.39393992
122CAMK2D0.38588742
123ADRBK10.37375790
124BRAF0.37317330
125BRSK10.37130183
126DYRK20.36963627
127ERBB20.36811088
128DDR20.36777140
129BRD40.36585807
130PRKDC0.36482221
131MAP3K10.36088501
132PRKG10.35534646
133CAMK2G0.35512992
134SIK30.35208416
135MAP2K10.34877099
136PRKCB0.34602627
137FGFR20.34316637
138CSNK1E0.34043863
139ROCK20.33985465
140ERBB40.33277249
141PLK30.31029652
142MAPK150.30687659
143RPS6KA50.30420140
144MAPK90.29170541

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.06348945
2Synaptic vesicle cycle_Homo sapiens_hsa047213.45522383
3GABAergic synapse_Homo sapiens_hsa047272.90939785
4Olfactory transduction_Homo sapiens_hsa047402.76032301
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72392649
6Circadian entrainment_Homo sapiens_hsa047132.68542501
7Morphine addiction_Homo sapiens_hsa050322.59237016
8Glutamatergic synapse_Homo sapiens_hsa047242.54616673
9Long-term potentiation_Homo sapiens_hsa047202.54153227
10Amphetamine addiction_Homo sapiens_hsa050312.40344565
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35617558
12Dopaminergic synapse_Homo sapiens_hsa047282.24284029
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19009867
14Salivary secretion_Homo sapiens_hsa049702.00943860
15Insulin secretion_Homo sapiens_hsa049111.92087422
16Cholinergic synapse_Homo sapiens_hsa047251.90709818
17Taste transduction_Homo sapiens_hsa047421.88283313
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81869438
19Steroid biosynthesis_Homo sapiens_hsa001001.81436741
20Cocaine addiction_Homo sapiens_hsa050301.80459362
21Gastric acid secretion_Homo sapiens_hsa049711.76971234
22Long-term depression_Homo sapiens_hsa047301.76122685
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75776117
24Serotonergic synapse_Homo sapiens_hsa047261.74297729
25Butanoate metabolism_Homo sapiens_hsa006501.71742828
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69518512
27Renin secretion_Homo sapiens_hsa049241.67223700
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66265282
29Collecting duct acid secretion_Homo sapiens_hsa049661.60019288
30Oxytocin signaling pathway_Homo sapiens_hsa049211.59499221
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56952710
32Calcium signaling pathway_Homo sapiens_hsa040201.53819574
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49369296
34Gap junction_Homo sapiens_hsa045401.47911331
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42551313
36GnRH signaling pathway_Homo sapiens_hsa049121.41754904
37Basal cell carcinoma_Homo sapiens_hsa052171.37732828
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34715435
39Axon guidance_Homo sapiens_hsa043601.31353007
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26228387
41Cardiac muscle contraction_Homo sapiens_hsa042601.22042173
42Estrogen signaling pathway_Homo sapiens_hsa049151.20480309
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20321927
44cAMP signaling pathway_Homo sapiens_hsa040241.18959401
45Type II diabetes mellitus_Homo sapiens_hsa049301.15219625
46Protein export_Homo sapiens_hsa030601.15026277
47Hippo signaling pathway_Homo sapiens_hsa043901.13956852
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12658542
49Melanogenesis_Homo sapiens_hsa049161.10735656
50Glioma_Homo sapiens_hsa052141.07845476
51Vibrio cholerae infection_Homo sapiens_hsa051101.05990318
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05531411
53ErbB signaling pathway_Homo sapiens_hsa040121.04728174
54Selenocompound metabolism_Homo sapiens_hsa004501.02286718
55Oocyte meiosis_Homo sapiens_hsa041141.01920827
56Propanoate metabolism_Homo sapiens_hsa006401.00729835
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00493162
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98901122
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.98723727
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98414894
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93878793
62Regulation of autophagy_Homo sapiens_hsa041400.92252607
63Ether lipid metabolism_Homo sapiens_hsa005650.89786685
64Phototransduction_Homo sapiens_hsa047440.89746912
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.87126283
66Fatty acid elongation_Homo sapiens_hsa000620.84926168
67Dorso-ventral axis formation_Homo sapiens_hsa043200.83916281
68Dilated cardiomyopathy_Homo sapiens_hsa054140.80481865
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.79904875
70Fanconi anemia pathway_Homo sapiens_hsa034600.79861934
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78110538
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77856278
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77711256
74Alcoholism_Homo sapiens_hsa050340.77344917
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77205341
76Basal transcription factors_Homo sapiens_hsa030220.73449369
77MAPK signaling pathway_Homo sapiens_hsa040100.72239573
78Fatty acid metabolism_Homo sapiens_hsa012120.70826967
79Thyroid hormone synthesis_Homo sapiens_hsa049180.70739252
80Linoleic acid metabolism_Homo sapiens_hsa005910.70607109
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70399430
82Peroxisome_Homo sapiens_hsa041460.67635891
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67312393
84beta-Alanine metabolism_Homo sapiens_hsa004100.65966045
85Arginine and proline metabolism_Homo sapiens_hsa003300.65924826
86Pancreatic secretion_Homo sapiens_hsa049720.65522770
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65326998
88Choline metabolism in cancer_Homo sapiens_hsa052310.64474125
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.63715252
90Alzheimers disease_Homo sapiens_hsa050100.62988692
91RNA degradation_Homo sapiens_hsa030180.61521878
92mRNA surveillance pathway_Homo sapiens_hsa030150.60778910
93Type I diabetes mellitus_Homo sapiens_hsa049400.60236018
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60111988
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58408430
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58163029
97Endometrial cancer_Homo sapiens_hsa052130.58065566
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57758028
99Ras signaling pathway_Homo sapiens_hsa040140.57239921
100Oxidative phosphorylation_Homo sapiens_hsa001900.56728677
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56704316
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55560139
103Rap1 signaling pathway_Homo sapiens_hsa040150.55466041
104Wnt signaling pathway_Homo sapiens_hsa043100.54427555
105Glucagon signaling pathway_Homo sapiens_hsa049220.54346266
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54212309
107Parkinsons disease_Homo sapiens_hsa050120.53929757
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53755411
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51743653
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50679886
111Biosynthesis of amino acids_Homo sapiens_hsa012300.49928908
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49910780
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49778980
114mTOR signaling pathway_Homo sapiens_hsa041500.49629463
115Hedgehog signaling pathway_Homo sapiens_hsa043400.48905737
116Protein digestion and absorption_Homo sapiens_hsa049740.47703506
117VEGF signaling pathway_Homo sapiens_hsa043700.47200146
118Renal cell carcinoma_Homo sapiens_hsa052110.45186838
119Prion diseases_Homo sapiens_hsa050200.44453508
120Base excision repair_Homo sapiens_hsa034100.43683908
121Insulin signaling pathway_Homo sapiens_hsa049100.43596350
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43394069
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43327447
124TGF-beta signaling pathway_Homo sapiens_hsa043500.42888473
125Endocytosis_Homo sapiens_hsa041440.42441862
126Colorectal cancer_Homo sapiens_hsa052100.42107013
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.40566478
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39825982
129Huntingtons disease_Homo sapiens_hsa050160.38872749
130Nitrogen metabolism_Homo sapiens_hsa009100.38100434
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37816395
132Non-small cell lung cancer_Homo sapiens_hsa052230.37569324
133Inositol phosphate metabolism_Homo sapiens_hsa005620.36112907
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36004064
135AMPK signaling pathway_Homo sapiens_hsa041520.35834036
136Bile secretion_Homo sapiens_hsa049760.35703496
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35514564
138Circadian rhythm_Homo sapiens_hsa047100.34550886
139Ovarian steroidogenesis_Homo sapiens_hsa049130.34547866
140Tryptophan metabolism_Homo sapiens_hsa003800.34343213
141Spliceosome_Homo sapiens_hsa030400.33990429
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33921810
143Metabolic pathways_Homo sapiens_hsa011000.32690344
144Tight junction_Homo sapiens_hsa045300.28084164
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26424688

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