

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein localization to kinetochore (GO:0034501) | 5.88639214 |
| 2 | mitotic sister chromatid segregation (GO:0000070) | 5.66814658 |
| 3 | mitotic metaphase plate congression (GO:0007080) | 5.36504243 |
| 4 | protein localization to chromosome, centromeric region (GO:0071459) | 5.36164998 |
| 5 | sister chromatid segregation (GO:0000819) | 5.22464713 |
| 6 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 5.16836341 |
| 7 | mitotic chromosome condensation (GO:0007076) | 4.98537359 |
| 8 | DNA unwinding involved in DNA replication (GO:0006268) | 4.92578927 |
| 9 | kinetochore organization (GO:0051383) | 4.86375295 |
| 10 | metaphase plate congression (GO:0051310) | 4.73421122 |
| 11 | regulation of spindle organization (GO:0090224) | 4.72909945 |
| 12 | mitotic nuclear envelope disassembly (GO:0007077) | 4.56120162 |
| 13 | establishment of chromosome localization (GO:0051303) | 4.50924077 |
| 14 | DNA ligation (GO:0006266) | 4.50837949 |
| 15 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.46560170 |
| 16 | attachment of spindle microtubules to kinetochore (GO:0008608) | 4.37716943 |
| 17 | CENP-A containing nucleosome assembly (GO:0034080) | 4.36774855 |
| 18 | kinetochore assembly (GO:0051382) | 4.34257549 |
| 19 | DNA replication checkpoint (GO:0000076) | 4.29942954 |
| 20 | DNA replication initiation (GO:0006270) | 4.29531947 |
| 21 | chromatin remodeling at centromere (GO:0031055) | 4.27804999 |
| 22 | positive regulation of chromosome segregation (GO:0051984) | 4.24697640 |
| 23 | regulation of mitotic spindle organization (GO:0060236) | 4.23995018 |
| 24 | DNA strand elongation (GO:0022616) | 4.23465124 |
| 25 | membrane disassembly (GO:0030397) | 4.22321159 |
| 26 | nuclear envelope disassembly (GO:0051081) | 4.22321159 |
| 27 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.18882636 |
| 28 | DNA replication-independent nucleosome organization (GO:0034724) | 4.05104768 |
| 29 | DNA replication-independent nucleosome assembly (GO:0006336) | 4.05104768 |
| 30 | protein localization to chromosome (GO:0034502) | 4.01872586 |
| 31 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.93568667 |
| 32 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.93568667 |
| 33 | regulation of chromosome segregation (GO:0051983) | 3.93186378 |
| 34 | nuclear pore complex assembly (GO:0051292) | 3.92507381 |
| 35 | nuclear pore organization (GO:0006999) | 3.91587654 |
| 36 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.91202362 |
| 37 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.91202362 |
| 38 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.91202362 |
| 39 | spindle checkpoint (GO:0031577) | 3.89978566 |
| 40 | meiotic chromosome segregation (GO:0045132) | 3.89758466 |
| 41 | mitotic recombination (GO:0006312) | 3.85371996 |
| 42 | telomere maintenance via recombination (GO:0000722) | 3.84544562 |
| 43 | chromosome segregation (GO:0007059) | 3.76688846 |
| 44 | negative regulation of chromosome segregation (GO:0051985) | 3.71979158 |
| 45 | spindle assembly checkpoint (GO:0071173) | 3.69309828 |
| 46 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.68326301 |
| 47 | histone exchange (GO:0043486) | 3.66123082 |
| 48 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.64802562 |
| 49 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.64802562 |
| 50 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.64802562 |
| 51 | negative regulation of sister chromatid segregation (GO:0033046) | 3.64802562 |
| 52 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.64616965 |
| 53 | mitotic spindle assembly checkpoint (GO:0007094) | 3.61459800 |
| 54 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.59603037 |
| 55 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.58216548 |
| 56 | mitotic spindle checkpoint (GO:0071174) | 3.57979762 |
| 57 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.57844179 |
| 58 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.57829108 |
| 59 | establishment of integrated proviral latency (GO:0075713) | 3.54843078 |
| 60 | chromatin assembly or disassembly (GO:0006333) | 3.53976620 |
| 61 | ribosomal small subunit biogenesis (GO:0042274) | 3.53826898 |
| 62 | regulation of sister chromatid segregation (GO:0033045) | 3.44183683 |
| 63 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.44183683 |
| 64 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.44183683 |
| 65 | regulation of sister chromatid cohesion (GO:0007063) | 3.43680963 |
| 66 | chromosome condensation (GO:0030261) | 3.43481101 |
| 67 | telomere maintenance via telomere lengthening (GO:0010833) | 3.43284497 |
| 68 | mitotic sister chromatid cohesion (GO:0007064) | 3.36235309 |
| 69 | nuclear envelope organization (GO:0006998) | 3.35313120 |
| 70 | microtubule depolymerization (GO:0007019) | 3.33910952 |
| 71 | regulation of centrosome cycle (GO:0046605) | 3.32436327 |
| 72 | DNA duplex unwinding (GO:0032508) | 3.29355314 |
| 73 | DNA geometric change (GO:0032392) | 3.29230139 |
| 74 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.28327080 |
| 75 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.22458287 |
| 76 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.22389503 |
| 77 | regulation of exit from mitosis (GO:0007096) | 3.16660679 |
| 78 | DNA topological change (GO:0006265) | 3.16393218 |
| 79 | histone-serine phosphorylation (GO:0035404) | 3.14309515 |
| 80 | formation of translation preinitiation complex (GO:0001731) | 3.14094197 |
| 81 | IMP biosynthetic process (GO:0006188) | 3.11485379 |
| 82 | ATP-dependent chromatin remodeling (GO:0043044) | 3.10343430 |
| 83 | DNA conformation change (GO:0071103) | 3.09753373 |
| 84 | regulation of telomere maintenance via telomerase (GO:0032210) | 3.09508780 |
| 85 | nucleobase biosynthetic process (GO:0046112) | 3.09268518 |
| 86 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.08870771 |
| 87 | regulation of spindle checkpoint (GO:0090231) | 3.08693214 |
| 88 | establishment of mitotic spindle localization (GO:0040001) | 3.08353911 |
| 89 | mitotic cell cycle (GO:0000278) | 3.06251489 |
| 90 | DNA packaging (GO:0006323) | 3.04793616 |
| 91 | protein K6-linked ubiquitination (GO:0085020) | 3.03071860 |
| 92 | pore complex assembly (GO:0046931) | 2.98933875 |
| 93 | proteasome assembly (GO:0043248) | 2.98738661 |
| 94 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.97159743 |
| 95 | viral transcription (GO:0019083) | 2.96185152 |
| 96 | regulation of mitochondrial translation (GO:0070129) | 2.96062762 |
| 97 | spindle assembly involved in mitosis (GO:0090307) | 2.93665072 |
| 98 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.93052083 |
| 99 | heterochromatin organization (GO:0070828) | 2.92475179 |
| 100 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.92460622 |
| 101 | maturation of SSU-rRNA (GO:0030490) | 2.91493834 |
| 102 | ventricular cardiac muscle cell development (GO:0055015) | 2.91056331 |
| 103 | translational termination (GO:0006415) | 2.89144845 |
| 104 | spindle organization (GO:0007051) | 2.87178569 |
| 105 | ribosomal small subunit assembly (GO:0000028) | 2.87142958 |
| 106 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.86248463 |
| 107 | negative regulation of ligase activity (GO:0051352) | 2.86248463 |
| 108 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.85030595 |
| 109 | base-excision repair (GO:0006284) | 2.84098614 |
| 110 | IMP metabolic process (GO:0046040) | 2.81218420 |
| 111 | telomere maintenance (GO:0000723) | 2.80200289 |
| 112 | negative regulation of mitosis (GO:0045839) | 2.79134891 |
| 113 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.79003077 |
| 114 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla | 2.78773992 |
| 115 | telomere organization (GO:0032200) | 2.78523974 |
| 116 | mitotic G2/M transition checkpoint (GO:0044818) | 2.77704824 |
| 117 | chromosome organization (GO:0051276) | 2.77103353 |
| 118 | negative regulation of RNA splicing (GO:0033119) | 2.76811077 |
| 119 | regulation of centriole replication (GO:0046599) | 2.75666651 |
| 120 | ribosome assembly (GO:0042255) | 2.74980073 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.30303072 |
| 2 | * FOXM1_23109430_ChIP-Seq_U2OS_Human | 6.99625678 |
| 3 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.37013370 |
| 4 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 4.26540914 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.63291945 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.47526460 |
| 7 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.64782355 |
| 8 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.64684095 |
| 9 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.62328032 |
| 10 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.48488032 |
| 11 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.45580385 |
| 12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.39863760 |
| 13 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.35054786 |
| 14 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.23082619 |
| 15 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.21928146 |
| 16 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.16634672 |
| 17 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.16400878 |
| 18 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.15618816 |
| 19 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.09522909 |
| 20 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.01079368 |
| 21 | MYC_22102868_ChIP-Seq_BL_Human | 1.99319404 |
| 22 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.98034104 |
| 23 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.97963201 |
| 24 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.95492749 |
| 25 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.86156055 |
| 26 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.80569510 |
| 27 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.78436883 |
| 28 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.76058518 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.74885712 |
| 30 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.73737881 |
| 31 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.72977137 |
| 32 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.72077941 |
| 33 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.70049293 |
| 34 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.66345148 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.64046536 |
| 36 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.62601149 |
| 37 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.61880517 |
| 38 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.61355853 |
| 39 | * MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.59401103 |
| 40 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.49706279 |
| 41 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.47571600 |
| 42 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.46334359 |
| 43 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.46079900 |
| 44 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.45956838 |
| 45 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.45474329 |
| 46 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.44148862 |
| 47 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.43529396 |
| 48 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.39484020 |
| 49 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.39065048 |
| 50 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.35981112 |
| 51 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.34503417 |
| 52 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.31456592 |
| 53 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.30030439 |
| 54 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.28288770 |
| 55 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.25852806 |
| 56 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.25515966 |
| 57 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.25152616 |
| 58 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.22211570 |
| 59 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.21671505 |
| 60 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.21671444 |
| 61 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.21556015 |
| 62 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.20023117 |
| 63 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.18895706 |
| 64 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16843423 |
| 65 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.13949109 |
| 66 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.13192526 |
| 67 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.12262017 |
| 68 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.11827042 |
| 69 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.09836051 |
| 70 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.09275644 |
| 71 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.08849330 |
| 72 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.07843892 |
| 73 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.05722855 |
| 74 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.04572044 |
| 75 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02868787 |
| 76 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.01943906 |
| 77 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.01816741 |
| 78 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.01686769 |
| 79 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.99304805 |
| 80 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.98955251 |
| 81 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.98157501 |
| 82 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.98150640 |
| 83 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.98105175 |
| 84 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.96163962 |
| 85 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.93694937 |
| 86 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.92495259 |
| 87 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.91272585 |
| 88 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.90771083 |
| 89 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.90234958 |
| 90 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.88685649 |
| 91 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.87284808 |
| 92 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.85651546 |
| 93 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.84532829 |
| 94 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.83515422 |
| 95 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.83383684 |
| 96 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.82750188 |
| 97 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.82631015 |
| 98 | UTX_26944678_Chip-Seq_JUKART_Human | 0.81237624 |
| 99 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.78703302 |
| 100 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.78607921 |
| 101 | * TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.75490517 |
| 102 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.74820927 |
| 103 | * CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.74739401 |
| 104 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.74199747 |
| 105 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.73606848 |
| 106 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.73488588 |
| 107 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.72951160 |
| 108 | MAF_26560356_Chip-Seq_TH1_Human | 0.72732086 |
| 109 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.71759016 |
| 110 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.71560589 |
| 111 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.70655667 |
| 112 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.69574753 |
| 113 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.69422426 |
| 114 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.69099813 |
| 115 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.69071236 |
| 116 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.68975387 |
| 117 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.68602575 |
| 118 | MYB_26560356_Chip-Seq_TH1_Human | 0.68283530 |
| 119 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.68238456 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.55166208 |
| 2 | MP0003111_abnormal_nucleus_morphology | 5.15002345 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.71830285 |
| 4 | MP0003077_abnormal_cell_cycle | 4.34764868 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 4.18806892 |
| 6 | MP0008057_abnormal_DNA_replication | 3.68826652 |
| 7 | MP0008007_abnormal_cellular_replicative | 2.76587526 |
| 8 | MP0008932_abnormal_embryonic_tissue | 2.63942929 |
| 9 | MP0008058_abnormal_DNA_repair | 2.56484190 |
| 10 | MP0001730_embryonic_growth_arrest | 2.39781349 |
| 11 | MP0000350_abnormal_cell_proliferation | 2.36750109 |
| 12 | MP0002396_abnormal_hematopoietic_system | 2.28303893 |
| 13 | MP0010307_abnormal_tumor_latency | 2.19137181 |
| 14 | MP0003123_paternal_imprinting | 2.10094526 |
| 15 | MP0010352_gastrointestinal_tract_polyps | 2.03227086 |
| 16 | MP0001697_abnormal_embryo_size | 1.82449002 |
| 17 | MP0005380_embryogenesis_phenotype | 1.80714715 |
| 18 | MP0001672_abnormal_embryogenesis/_devel | 1.80714715 |
| 19 | MP0000490_abnormal_crypts_of | 1.80427543 |
| 20 | MP0005076_abnormal_cell_differentiation | 1.80374741 |
| 21 | MP0009697_abnormal_copulation | 1.69131665 |
| 22 | MP0004808_abnormal_hematopoietic_stem | 1.66598889 |
| 23 | MP0002085_abnormal_embryonic_tissue | 1.64955528 |
| 24 | MP0002080_prenatal_lethality | 1.64839274 |
| 25 | MP0008877_abnormal_DNA_methylation | 1.60976928 |
| 26 | MP0003984_embryonic_growth_retardation | 1.60049269 |
| 27 | MP0003718_maternal_effect | 1.59362456 |
| 28 | MP0002088_abnormal_embryonic_growth/wei | 1.55587318 |
| 29 | MP0001545_abnormal_hematopoietic_system | 1.55476175 |
| 30 | MP0005397_hematopoietic_system_phenotyp | 1.55476175 |
| 31 | MP0002019_abnormal_tumor_incidence | 1.54827686 |
| 32 | MP0000313_abnormal_cell_death | 1.52841721 |
| 33 | MP0000566_synostosis | 1.52154130 |
| 34 | MP0002084_abnormal_developmental_patter | 1.48345764 |
| 35 | MP0002086_abnormal_extraembryonic_tissu | 1.47690070 |
| 36 | MP0003786_premature_aging | 1.46952307 |
| 37 | MP0004197_abnormal_fetal_growth/weight/ | 1.38493816 |
| 38 | MP0002938_white_spotting | 1.37230661 |
| 39 | MP0009278_abnormal_bone_marrow | 1.34408949 |
| 40 | MP0010030_abnormal_orbit_morphology | 1.34381199 |
| 41 | MP0001346_abnormal_lacrimal_gland | 1.27378691 |
| 42 | MP0003705_abnormal_hypodermis_morpholog | 1.24381164 |
| 43 | MP0008789_abnormal_olfactory_epithelium | 1.22646069 |
| 44 | MP0000703_abnormal_thymus_morphology | 1.21385943 |
| 45 | MP0003121_genomic_imprinting | 1.19916203 |
| 46 | MP0003136_yellow_coat_color | 1.19813477 |
| 47 | MP0009333_abnormal_splenocyte_physiolog | 1.19428734 |
| 48 | MP0006054_spinal_hemorrhage | 1.15757307 |
| 49 | MP0002398_abnormal_bone_marrow | 1.14638873 |
| 50 | MP0003567_abnormal_fetal_cardiomyocyte | 1.13471271 |
| 51 | MP0006035_abnormal_mitochondrial_morpho | 1.12152364 |
| 52 | MP0002210_abnormal_sex_determination | 1.11275437 |
| 53 | MP0009379_abnormal_foot_pigmentation | 1.10166606 |
| 54 | MP0000049_abnormal_middle_ear | 1.09694842 |
| 55 | MP0002722_abnormal_immune_system | 1.08265913 |
| 56 | MP0008995_early_reproductive_senescence | 1.07344974 |
| 57 | MP0003656_abnormal_erythrocyte_physiolo | 1.05332391 |
| 58 | MP0005023_abnormal_wound_healing | 1.03004068 |
| 59 | MP0002234_abnormal_pharynx_morphology | 1.02604647 |
| 60 | MP0000858_altered_metastatic_potential | 1.01873187 |
| 61 | MP0000689_abnormal_spleen_morphology | 1.01433141 |
| 62 | MP0001529_abnormal_vocalization | 1.01395057 |
| 63 | MP0001293_anophthalmia | 1.00909042 |
| 64 | MP0005499_abnormal_olfactory_system | 0.99823408 |
| 65 | MP0005394_taste/olfaction_phenotype | 0.99823408 |
| 66 | MP0006036_abnormal_mitochondrial_physio | 0.99608744 |
| 67 | MP0002653_abnormal_ependyma_morphology | 0.98479316 |
| 68 | MP0001145_abnormal_male_reproductive | 0.98337588 |
| 69 | MP0002249_abnormal_larynx_morphology | 0.98158260 |
| 70 | MP0000372_irregular_coat_pigmentation | 0.98058287 |
| 71 | MP0003566_abnormal_cell_adhesion | 0.97508831 |
| 72 | MP0000678_abnormal_parathyroid_gland | 0.97495137 |
| 73 | MP0003763_abnormal_thymus_physiology | 0.97408869 |
| 74 | MP0001929_abnormal_gametogenesis | 0.97389856 |
| 75 | MP0001915_intracranial_hemorrhage | 0.96972947 |
| 76 | MP0005501_abnormal_skin_physiology | 0.94040139 |
| 77 | MP0002102_abnormal_ear_morphology | 0.93917011 |
| 78 | MP0005621_abnormal_cell_physiology | 0.93370130 |
| 79 | MP0009053_abnormal_anal_canal | 0.93241106 |
| 80 | MP0003890_abnormal_embryonic-extraembry | 0.90183665 |
| 81 | MP0003186_abnormal_redox_activity | 0.89822681 |
| 82 | MP0004233_abnormal_muscle_weight | 0.89727723 |
| 83 | MP0000653_abnormal_sex_gland | 0.89640904 |
| 84 | MP0002161_abnormal_fertility/fecundity | 0.87822721 |
| 85 | MP0002132_abnormal_respiratory_system | 0.86629905 |
| 86 | MP0003937_abnormal_limbs/digits/tail_de | 0.86612404 |
| 87 | MP0001119_abnormal_female_reproductive | 0.86403672 |
| 88 | MP0005384_cellular_phenotype | 0.85597082 |
| 89 | MP0005395_other_phenotype | 0.85304819 |
| 90 | MP0002429_abnormal_blood_cell | 0.84563475 |
| 91 | MP0002160_abnormal_reproductive_system | 0.83951029 |
| 92 | MP0009672_abnormal_birth_weight | 0.82467908 |
| 93 | MP0005171_absent_coat_pigmentation | 0.80397793 |
| 94 | MP0000537_abnormal_urethra_morphology | 0.80356461 |
| 95 | MP0003698_abnormal_male_reproductive | 0.80244802 |
| 96 | MP0001849_ear_inflammation | 0.77748312 |
| 97 | MP0002111_abnormal_tail_morphology | 0.77506090 |
| 98 | MP0003119_abnormal_digestive_system | 0.77114484 |
| 99 | MP0003861_abnormal_nervous_system | 0.76436138 |
| 100 | MP0003315_abnormal_perineum_morphology | 0.76429897 |
| 101 | MP0000733_abnormal_muscle_development | 0.76041429 |
| 102 | MP0003806_abnormal_nucleotide_metabolis | 0.75988477 |
| 103 | MP0002163_abnormal_gland_morphology | 0.75720275 |
| 104 | MP0002233_abnormal_nose_morphology | 0.73877854 |
| 105 | MP0001727_abnormal_embryo_implantation | 0.72527333 |
| 106 | MP0005408_hypopigmentation | 0.72011574 |
| 107 | MP0003755_abnormal_palate_morphology | 0.71598053 |
| 108 | MP0004147_increased_porphyrin_level | 0.70629579 |
| 109 | MP0000428_abnormal_craniofacial_morphol | 0.68783854 |
| 110 | MP0000716_abnormal_immune_system | 0.68778800 |
| 111 | MP0004264_abnormal_extraembryonic_tissu | 0.68324498 |
| 112 | MP0000358_abnormal_cell_content/ | 0.67257340 |
| 113 | MP0009703_decreased_birth_body | 0.66298433 |
| 114 | MP0002925_abnormal_cardiovascular_devel | 0.65274641 |
| 115 | MP0002092_abnormal_eye_morphology | 0.64969653 |
| 116 | MP0006292_abnormal_olfactory_placode | 0.64655581 |
| 117 | MP0003115_abnormal_respiratory_system | 0.64410764 |
| 118 | MP0003699_abnormal_female_reproductive | 0.64271574 |
| 119 | MP0000477_abnormal_intestine_morphology | 0.63988103 |
| 120 | MP0001661_extended_life_span | 0.62708877 |
| 121 | MP0002932_abnormal_joint_morphology | 0.61429669 |
| 122 | MP0003942_abnormal_urinary_system | 0.61279462 |
| 123 | MP0003448_altered_tumor_morphology | 0.60730677 |
| 124 | MP0002405_respiratory_system_inflammati | 0.59046190 |
| 125 | MP0000631_abnormal_neuroendocrine_gland | 0.58110126 |
| 126 | MP0002177_abnormal_outer_ear | 0.57678984 |
| 127 | MP0008770_decreased_survivor_rate | 0.57212988 |
| 128 | MP0000762_abnormal_tongue_morphology | 0.57064432 |
| 129 | MP0000432_abnormal_head_morphology | 0.56532700 |
| 130 | MP0009250_abnormal_appendicular_skeleto | 0.55053848 |
| 131 | MP0000579_abnormal_nail_morphology | 0.54921718 |
| 132 | MP0005389_reproductive_system_phenotype | 0.54901561 |
| 133 | MP0001286_abnormal_eye_development | 0.54676492 |
| 134 | MP0003221_abnormal_cardiomyocyte_apopto | 0.54239080 |
| 135 | MP0001243_abnormal_dermal_layer | 0.53258592 |
| 136 | MP0003935_abnormal_craniofacial_develop | 0.52125378 |
| 137 | MP0000266_abnormal_heart_morphology | 0.51252290 |
| 138 | MP0001919_abnormal_reproductive_system | 0.50846189 |
| 139 | MP0002877_abnormal_melanocyte_morpholog | 0.50186451 |
| 140 | MP0002697_abnormal_eye_size | 0.49992822 |
| 141 | MP0002420_abnormal_adaptive_immunity | 0.49443423 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chromsome breakage (HP:0040012) | 4.45424224 |
| 2 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.34390115 |
| 3 | Birth length less than 3rd percentile (HP:0003561) | 3.83146584 |
| 4 | Reticulocytopenia (HP:0001896) | 3.72364694 |
| 5 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.66203155 |
| 6 | Selective tooth agenesis (HP:0001592) | 3.44267992 |
| 7 | Patellar aplasia (HP:0006443) | 3.36010140 |
| 8 | Abnormality of chromosome stability (HP:0003220) | 3.29553991 |
| 9 | Meckel diverticulum (HP:0002245) | 3.29031765 |
| 10 | Breast hypoplasia (HP:0003187) | 3.23463011 |
| 11 | Small intestinal stenosis (HP:0012848) | 3.14120829 |
| 12 | Duodenal stenosis (HP:0100867) | 3.14120829 |
| 13 | Abnormality of the ileum (HP:0001549) | 3.14120140 |
| 14 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.12307151 |
| 15 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.07343271 |
| 16 | Broad distal phalanx of finger (HP:0009836) | 3.02374547 |
| 17 | Abnormality of the preputium (HP:0100587) | 3.02212223 |
| 18 | Ectopic kidney (HP:0000086) | 2.99453265 |
| 19 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.98184132 |
| 20 | Abnormal number of erythroid precursors (HP:0012131) | 2.96976138 |
| 21 | Increased nuchal translucency (HP:0010880) | 2.95113233 |
| 22 | Myelodysplasia (HP:0002863) | 2.93251570 |
| 23 | Medulloblastoma (HP:0002885) | 2.90008052 |
| 24 | Microvesicular hepatic steatosis (HP:0001414) | 2.81365560 |
| 25 | Carpal bone hypoplasia (HP:0001498) | 2.80364530 |
| 26 | Oral leukoplakia (HP:0002745) | 2.77887176 |
| 27 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.74995211 |
| 28 | Short 4th metacarpal (HP:0010044) | 2.74995211 |
| 29 | Absent thumb (HP:0009777) | 2.73590925 |
| 30 | Absent radius (HP:0003974) | 2.71702679 |
| 31 | Impulsivity (HP:0100710) | 2.64545645 |
| 32 | Colon cancer (HP:0003003) | 2.63402813 |
| 33 | Aplastic anemia (HP:0001915) | 2.62994874 |
| 34 | Ependymoma (HP:0002888) | 2.57357144 |
| 35 | Abnormal lung lobation (HP:0002101) | 2.56503408 |
| 36 | Abnormality of the duodenum (HP:0002246) | 2.55136222 |
| 37 | Absent forearm bone (HP:0003953) | 2.52624099 |
| 38 | Aplasia involving forearm bones (HP:0009822) | 2.52624099 |
| 39 | Rhabdomyosarcoma (HP:0002859) | 2.50246460 |
| 40 | Sloping forehead (HP:0000340) | 2.49967814 |
| 41 | Abnormality of the anterior horn cell (HP:0006802) | 2.46997707 |
| 42 | Degeneration of anterior horn cells (HP:0002398) | 2.46997707 |
| 43 | High pitched voice (HP:0001620) | 2.46245701 |
| 44 | Volvulus (HP:0002580) | 2.46237916 |
| 45 | Abnormal number of incisors (HP:0011064) | 2.42579675 |
| 46 | 11 pairs of ribs (HP:0000878) | 2.42397273 |
| 47 | Bone marrow hypocellularity (HP:0005528) | 2.41157648 |
| 48 | Basal cell carcinoma (HP:0002671) | 2.40977905 |
| 49 | Cafe-au-lait spot (HP:0000957) | 2.40583000 |
| 50 | Proximal placement of thumb (HP:0009623) | 2.37068453 |
| 51 | Deviation of the thumb (HP:0009603) | 2.36496967 |
| 52 | Duplicated collecting system (HP:0000081) | 2.35295184 |
| 53 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.34562214 |
| 54 | Abnormality of the carotid arteries (HP:0005344) | 2.28870631 |
| 55 | Abnormality of cochlea (HP:0000375) | 2.28858209 |
| 56 | Abnormality of reticulocytes (HP:0004312) | 2.27212988 |
| 57 | Hypoplastic pelvis (HP:0008839) | 2.26571742 |
| 58 | Agnosia (HP:0010524) | 2.25242693 |
| 59 | Acute necrotizing encephalopathy (HP:0006965) | 2.25160890 |
| 60 | Duplication of thumb phalanx (HP:0009942) | 2.24633522 |
| 61 | Pallor (HP:0000980) | 2.23703880 |
| 62 | Tracheoesophageal fistula (HP:0002575) | 2.23137888 |
| 63 | Absent epiphyses (HP:0010577) | 2.22781067 |
| 64 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.22781067 |
| 65 | Atresia of the external auditory canal (HP:0000413) | 2.21005214 |
| 66 | Abnormality of the calcaneus (HP:0008364) | 2.20022309 |
| 67 | Cortical dysplasia (HP:0002539) | 2.19029603 |
| 68 | High anterior hairline (HP:0009890) | 2.17536211 |
| 69 | Abnormality of glycolysis (HP:0004366) | 2.17533202 |
| 70 | Neoplasm of the pancreas (HP:0002894) | 2.17153373 |
| 71 | Overlapping toe (HP:0001845) | 2.17137807 |
| 72 | Squamous cell carcinoma (HP:0002860) | 2.15854559 |
| 73 | Progressive muscle weakness (HP:0003323) | 2.15404828 |
| 74 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.15145557 |
| 75 | Short thumb (HP:0009778) | 2.13873317 |
| 76 | Rough bone trabeculation (HP:0100670) | 2.13675590 |
| 77 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.12417311 |
| 78 | Ankle contracture (HP:0006466) | 2.10809887 |
| 79 | Prominent nose (HP:0000448) | 2.10792442 |
| 80 | Horseshoe kidney (HP:0000085) | 2.08477443 |
| 81 | Acute encephalopathy (HP:0006846) | 2.06162944 |
| 82 | Premature graying of hair (HP:0002216) | 2.04483527 |
| 83 | Trismus (HP:0000211) | 2.03668062 |
| 84 | Hepatocellular necrosis (HP:0001404) | 2.02672729 |
| 85 | Abnormality of the renal collecting system (HP:0004742) | 2.01462215 |
| 86 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.00511305 |
| 87 | Increased CSF lactate (HP:0002490) | 2.00344206 |
| 88 | Short middle phalanx of the 5th finger (HP:0004220) | 1.98555045 |
| 89 | Triphalangeal thumb (HP:0001199) | 1.98476467 |
| 90 | Missing ribs (HP:0000921) | 1.97389378 |
| 91 | Facial hemangioma (HP:0000329) | 1.96895141 |
| 92 | Abnormality of the labia minora (HP:0012880) | 1.96346777 |
| 93 | Increased serum pyruvate (HP:0003542) | 1.96335826 |
| 94 | Mitochondrial inheritance (HP:0001427) | 1.96262242 |
| 95 | Clubbing of toes (HP:0100760) | 1.95213572 |
| 96 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.94980406 |
| 97 | Neoplasm of striated muscle (HP:0009728) | 1.94845352 |
| 98 | Facial cleft (HP:0002006) | 1.93967424 |
| 99 | Choanal atresia (HP:0000453) | 1.92561929 |
| 100 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.89988349 |
| 101 | Abnormality of DNA repair (HP:0003254) | 1.88585347 |
| 102 | Abnormality of chromosome segregation (HP:0002916) | 1.87972090 |
| 103 | Morphological abnormality of the inner ear (HP:0011390) | 1.86905676 |
| 104 | Hepatic necrosis (HP:0002605) | 1.85981814 |
| 105 | Pancytopenia (HP:0001876) | 1.85741828 |
| 106 | Abnormal gallbladder physiology (HP:0012438) | 1.85196410 |
| 107 | Cholecystitis (HP:0001082) | 1.85196410 |
| 108 | Abnormality of abdominal situs (HP:0011620) | 1.84709566 |
| 109 | Abdominal situs inversus (HP:0003363) | 1.84709566 |
| 110 | Type I transferrin isoform profile (HP:0003642) | 1.84126160 |
| 111 | Abnormality of the fingertips (HP:0001211) | 1.83028965 |
| 112 | Multiple enchondromatosis (HP:0005701) | 1.81944015 |
| 113 | Cellular immunodeficiency (HP:0005374) | 1.81733026 |
| 114 | Supernumerary spleens (HP:0009799) | 1.81223659 |
| 115 | Embryonal neoplasm (HP:0002898) | 1.81117772 |
| 116 | Embryonal renal neoplasm (HP:0011794) | 1.80580488 |
| 117 | Slender long bone (HP:0003100) | 1.80503476 |
| 118 | Testicular atrophy (HP:0000029) | 1.79683036 |
| 119 | Macrocytic anemia (HP:0001972) | 1.79673882 |
| 120 | Broad palm (HP:0001169) | 1.78993685 |
| 121 | Increased serum lactate (HP:0002151) | 1.78822356 |
| 122 | Abnormality of the 4th metacarpal (HP:0010012) | 1.75849450 |
| 123 | Arteriovenous malformation (HP:0100026) | 1.74855840 |
| 124 | Microretrognathia (HP:0000308) | 1.74693147 |
| 125 | Septate vagina (HP:0001153) | 1.74637203 |
| 126 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 1.74411267 |
| 127 | Irregular epiphyses (HP:0010582) | 1.74356013 |
| 128 | Astrocytoma (HP:0009592) | 1.74027375 |
| 129 | Abnormality of the astrocytes (HP:0100707) | 1.74027375 |
| 130 | Premature ovarian failure (HP:0008209) | 1.73228921 |
| 131 | Hypergonadotropic hypogonadism (HP:0000815) | 1.72020701 |
| 132 | Long eyelashes (HP:0000527) | 1.72003594 |
| 133 | Ureteral duplication (HP:0000073) | 1.71758739 |
| 134 | Neoplasm of the oral cavity (HP:0100649) | 1.71371228 |
| 135 | Cleft eyelid (HP:0000625) | 1.69915937 |
| 136 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.68105163 |
| 137 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.68105163 |
| 138 | Hypoplasia of the pons (HP:0012110) | 1.68094511 |
| 139 | Cerebral edema (HP:0002181) | 1.67072131 |
| 140 | Increased hepatocellular lipid droplets (HP:0006565) | 1.66695330 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.22401495 |
| 2 | CDC7 | 4.76253356 |
| 3 | WEE1 | 3.75809143 |
| 4 | NEK2 | 3.68577247 |
| 5 | VRK2 | 3.21231445 |
| 6 | TTK | 3.01606213 |
| 7 | EEF2K | 2.35930815 |
| 8 | EIF2AK1 | 2.35062676 |
| 9 | BRSK2 | 2.34535638 |
| 10 | STK10 | 2.33340922 |
| 11 | PLK1 | 2.28365841 |
| 12 | CDK12 | 2.26178460 |
| 13 | PLK4 | 2.24195786 |
| 14 | NEK1 | 2.17189184 |
| 15 | BRSK1 | 2.16497251 |
| 16 | TESK2 | 2.00450150 |
| 17 | AURKB | 1.92908536 |
| 18 | SMG1 | 1.89557552 |
| 19 | MAP3K8 | 1.76685399 |
| 20 | MAP3K10 | 1.68209338 |
| 21 | CDK7 | 1.65707800 |
| 22 | ATR | 1.59162139 |
| 23 | CHEK2 | 1.54153406 |
| 24 | SRPK1 | 1.54097955 |
| 25 | AURKA | 1.53403793 |
| 26 | STK4 | 1.51809569 |
| 27 | RPS6KB2 | 1.49016230 |
| 28 | RPS6KA4 | 1.44592762 |
| 29 | CDK4 | 1.43648563 |
| 30 | PLK3 | 1.43039848 |
| 31 | CCNB1 | 1.40270006 |
| 32 | CHEK1 | 1.29757251 |
| 33 | ACVR1B | 1.25400245 |
| 34 | VRK1 | 1.25314784 |
| 35 | TLK1 | 1.23565999 |
| 36 | NME2 | 1.23320433 |
| 37 | NME1 | 1.18849508 |
| 38 | MELK | 1.18735560 |
| 39 | PKN2 | 1.16573287 |
| 40 | PAK4 | 1.16470633 |
| 41 | TAF1 | 1.15961719 |
| 42 | MKNK1 | 1.14929568 |
| 43 | PASK | 1.13737050 |
| 44 | STK3 | 1.10007556 |
| 45 | TRIB3 | 1.09499321 |
| 46 | TSSK6 | 1.04961363 |
| 47 | DYRK3 | 1.03766894 |
| 48 | MAP4K1 | 0.92018225 |
| 49 | ATM | 0.91549463 |
| 50 | EIF2AK3 | 0.88998686 |
| 51 | MST1R | 0.87961303 |
| 52 | CDK6 | 0.86260404 |
| 53 | CDK2 | 0.85000257 |
| 54 | LRRK2 | 0.84349177 |
| 55 | CLK1 | 0.83529169 |
| 56 | SCYL2 | 0.83216826 |
| 57 | MKNK2 | 0.78460476 |
| 58 | PAK1 | 0.77979166 |
| 59 | IRAK3 | 0.77699783 |
| 60 | PDK2 | 0.77242881 |
| 61 | LATS2 | 0.77043356 |
| 62 | BRD4 | 0.75268753 |
| 63 | CDK1 | 0.71764013 |
| 64 | CDK8 | 0.70266997 |
| 65 | PIM1 | 0.70213088 |
| 66 | TESK1 | 0.69782802 |
| 67 | BCKDK | 0.67467182 |
| 68 | BRAF | 0.67286707 |
| 69 | TGFBR1 | 0.66755901 |
| 70 | EPHA2 | 0.66385009 |
| 71 | FLT3 | 0.61197925 |
| 72 | NUAK1 | 0.60657363 |
| 73 | ICK | 0.59446875 |
| 74 | ZAK | 0.58957279 |
| 75 | TTN | 0.55138604 |
| 76 | PBK | 0.54143747 |
| 77 | MOS | 0.53408563 |
| 78 | ALK | 0.53141833 |
| 79 | MTOR | 0.52486948 |
| 80 | ARAF | 0.52341165 |
| 81 | LATS1 | 0.51000087 |
| 82 | MAP2K3 | 0.50888926 |
| 83 | MAPK11 | 0.50509943 |
| 84 | MARK3 | 0.47527403 |
| 85 | MET | 0.47105196 |
| 86 | EIF2AK2 | 0.44872223 |
| 87 | CSNK2A1 | 0.43804392 |
| 88 | AKT2 | 0.43718436 |
| 89 | CDK18 | 0.42617704 |
| 90 | PRKCI | 0.40583345 |
| 91 | CSNK2A2 | 0.39514864 |
| 92 | KDR | 0.39022351 |
| 93 | MAP3K11 | 0.38644703 |
| 94 | TAOK1 | 0.38099715 |
| 95 | GRK6 | 0.37869216 |
| 96 | MAPKAPK3 | 0.35480117 |
| 97 | MAPKAPK2 | 0.34695648 |
| 98 | ILK | 0.33870770 |
| 99 | CDK14 | 0.33734040 |
| 100 | PIM2 | 0.32368998 |
| 101 | SIK1 | 0.31648274 |
| 102 | STK16 | 0.31313214 |
| 103 | CSNK1G3 | 0.31271120 |
| 104 | MAP3K6 | 0.30816610 |
| 105 | MAPKAPK5 | 0.30205643 |
| 106 | UHMK1 | 0.30175890 |
| 107 | PRKDC | 0.29647772 |
| 108 | CDK9 | 0.29361128 |
| 109 | DAPK1 | 0.29073719 |
| 110 | CSF1R | 0.28698804 |
| 111 | NEK9 | 0.28566919 |
| 112 | CDK11A | 0.28160359 |
| 113 | TRIM28 | 0.27857690 |
| 114 | RPS6KA5 | 0.27788336 |
| 115 | BTK | 0.26551601 |
| 116 | MAPK14 | 0.25732049 |
| 117 | BMX | 0.25430578 |
| 118 | PAK2 | 0.25036077 |
| 119 | CDK15 | 0.24986512 |
| 120 | CSNK1E | 0.24225806 |
| 121 | AKT1 | 0.23362539 |
| 122 | CSNK1G1 | 0.19361336 |
| 123 | CSNK1A1L | 0.18554993 |
| 124 | RAF1 | 0.18084408 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.04817506 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.07819565 |
| 3 | Cell cycle_Homo sapiens_hsa04110 | 3.53672600 |
| 4 | Base excision repair_Homo sapiens_hsa03410 | 3.28201731 |
| 5 | Spliceosome_Homo sapiens_hsa03040 | 3.16561043 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 3.14154266 |
| 7 | RNA transport_Homo sapiens_hsa03013 | 3.05738649 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.04295290 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.74000587 |
| 10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.54340806 |
| 11 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.52748509 |
| 12 | RNA polymerase_Homo sapiens_hsa03020 | 2.46754343 |
| 13 | Ribosome_Homo sapiens_hsa03010 | 2.46026601 |
| 14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.07898644 |
| 15 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.07392021 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.04067229 |
| 17 | p53 signaling pathway_Homo sapiens_hsa04115 | 2.03004979 |
| 18 | Proteasome_Homo sapiens_hsa03050 | 2.02319382 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.98496957 |
| 20 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.90561795 |
| 21 | Basal transcription factors_Homo sapiens_hsa03022 | 1.78063070 |
| 22 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.64114005 |
| 23 | Parkinsons disease_Homo sapiens_hsa05012 | 1.60791150 |
| 24 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.53756328 |
| 25 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.52582392 |
| 26 | Huntingtons disease_Homo sapiens_hsa05016 | 1.46221748 |
| 27 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.45847614 |
| 28 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.32513629 |
| 29 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.28448971 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.23922557 |
| 31 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.20912736 |
| 32 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.20436091 |
| 33 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.10920692 |
| 34 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.09947812 |
| 35 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.08342194 |
| 36 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.06685896 |
| 37 | HTLV-I infection_Homo sapiens_hsa05166 | 1.06063846 |
| 38 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.04674699 |
| 39 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.03240014 |
| 40 | Purine metabolism_Homo sapiens_hsa00230 | 1.01444338 |
| 41 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.00406631 |
| 42 | Protein export_Homo sapiens_hsa03060 | 0.94349129 |
| 43 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.90785833 |
| 44 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.90745236 |
| 45 | Alzheimers disease_Homo sapiens_hsa05010 | 0.90665623 |
| 46 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.82760072 |
| 47 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.82166666 |
| 48 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.81660180 |
| 49 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.79712911 |
| 50 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.79064547 |
| 51 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.78146002 |
| 52 | Apoptosis_Homo sapiens_hsa04210 | 0.73840002 |
| 53 | Thyroid cancer_Homo sapiens_hsa05216 | 0.70682202 |
| 54 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.70356641 |
| 55 | Colorectal cancer_Homo sapiens_hsa05210 | 0.69477272 |
| 56 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.69106719 |
| 57 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.69088388 |
| 58 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.66781046 |
| 59 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.66430592 |
| 60 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.65271781 |
| 61 | Hepatitis B_Homo sapiens_hsa05161 | 0.64637748 |
| 62 | Bladder cancer_Homo sapiens_hsa05219 | 0.63462597 |
| 63 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.62298478 |
| 64 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.60074453 |
| 65 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.58713280 |
| 66 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.57628998 |
| 67 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.57308315 |
| 68 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.56999265 |
| 69 | Shigellosis_Homo sapiens_hsa05131 | 0.56740741 |
| 70 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.55716949 |
| 71 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.54954121 |
| 72 | Metabolic pathways_Homo sapiens_hsa01100 | 0.53920950 |
| 73 | Measles_Homo sapiens_hsa05162 | 0.51697255 |
| 74 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.51239157 |
| 75 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.51030305 |
| 76 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.50276353 |
| 77 | Legionellosis_Homo sapiens_hsa05134 | 0.50055457 |
| 78 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.49806502 |
| 79 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.48789672 |
| 80 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.48373790 |
| 81 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.47756982 |
| 82 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.45918523 |
| 83 | Alcoholism_Homo sapiens_hsa05034 | 0.45763903 |
| 84 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.45762387 |
| 85 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.43514132 |
| 86 | Adherens junction_Homo sapiens_hsa04520 | 0.43481545 |
| 87 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.42964809 |
| 88 | Viral myocarditis_Homo sapiens_hsa05416 | 0.42946947 |
| 89 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.42569990 |
| 90 | Galactose metabolism_Homo sapiens_hsa00052 | 0.42484988 |
| 91 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.42399990 |
| 92 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.42276942 |
| 93 | Lysine degradation_Homo sapiens_hsa00310 | 0.41811574 |
| 94 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.39385731 |
| 95 | Influenza A_Homo sapiens_hsa05164 | 0.38958894 |
| 96 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.38487114 |
| 97 | Pathways in cancer_Homo sapiens_hsa05200 | 0.38237357 |
| 98 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.36613484 |
| 99 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.36586737 |
| 100 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.35638785 |
| 101 | Sulfur relay system_Homo sapiens_hsa04122 | 0.34964822 |
| 102 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.33756221 |
| 103 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.33176055 |
| 104 | Prostate cancer_Homo sapiens_hsa05215 | 0.33154473 |
| 105 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.32535539 |
| 106 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.32400010 |
| 107 | Leishmaniasis_Homo sapiens_hsa05140 | 0.32263786 |
| 108 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.32048895 |
| 109 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.31935175 |
| 110 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.31736398 |
| 111 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.30711052 |
| 112 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.26807713 |
| 113 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.26582525 |
| 114 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.26210829 |
| 115 | Endometrial cancer_Homo sapiens_hsa05213 | 0.25218150 |
| 116 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.25081508 |
| 117 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.24972614 |
| 118 | Melanoma_Homo sapiens_hsa05218 | 0.24800294 |
| 119 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.24222823 |
| 120 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.23522238 |
| 121 | Carbon metabolism_Homo sapiens_hsa01200 | 0.23071933 |
| 122 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.21892348 |
| 123 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.21808628 |
| 124 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.21166303 |
| 125 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.19885656 |
| 126 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.19749067 |
| 127 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.19278098 |
| 128 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.19016162 |
| 129 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.18805476 |
| 130 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.18693638 |
| 131 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.16636897 |
| 132 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.16545284 |
| 133 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.16422237 |
| 134 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.12742363 |
| 135 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.11318989 |

