TRPA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)8.43467365
2regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)7.91135922
3neuronal action potential (GO:0019228)7.83959492
4negative regulation of dendrite morphogenesis (GO:0050774)7.74284255
5adenosine metabolic process (GO:0046085)7.19808231
6negative regulation of complement activation (GO:0045916)7.06780862
7detection of temperature stimulus involved in sensory perception (GO:0050961)7.02389531
8detection of temperature stimulus involved in sensory perception of pain (GO:0050965)7.02389531
9detection of temperature stimulus (GO:0016048)6.73489491
10peripheral nervous system neuron development (GO:0048935)6.55951361
11virion attachment to host cell (GO:0019062)6.18364460
12adhesion of symbiont to host cell (GO:0044650)6.18364460
13behavioral response to pain (GO:0048266)6.15895255
14potassium ion export (GO:0071435)6.01426700
15mesodermal cell differentiation (GO:0048333)5.82305563
16phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)5.69288931
17negative regulation of protein activation cascade (GO:2000258)5.53055712
18neurofilament cytoskeleton organization (GO:0060052)5.52385953
19negative regulation of homotypic cell-cell adhesion (GO:0034111)5.44346107
20cellular response to vitamin (GO:0071295)5.35403348
21lung vasculature development (GO:0060426)5.26313975
22urinary tract smooth muscle contraction (GO:0014848)5.25379813
23adhesion of symbiont to host (GO:0044406)5.21077383
24cell adhesion mediated by integrin (GO:0033627)5.11820584
25endodermal cell differentiation (GO:0035987)5.09398452
26regulation of platelet aggregation (GO:0090330)4.75481966
27skin morphogenesis (GO:0043589)4.71398581
28cellular response to vitamin D (GO:0071305)4.68052401
29lung lobe morphogenesis (GO:0060463)4.66910073
30negative regulation of humoral immune response (GO:0002921)4.65018977
31membrane depolarization during action potential (GO:0086010)4.56601719
32chondrocyte proliferation (GO:0035988)4.53171189
33regulation of translational termination (GO:0006449)4.50021801
34proline transport (GO:0015824)4.47542390
35endocardial cushion development (GO:0003197)4.47333837
36respiratory tube development (GO:0030323)4.40456740
37protein heterotrimerization (GO:0070208)4.36640708
38regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.36575002
39negative regulation of dendrite development (GO:2000171)4.32234204
40midgut development (GO:0007494)4.32158736
41* response to pain (GO:0048265)4.29605924
42sequestering of extracellular ligand from receptor (GO:0035581)4.23308563
43extracellular matrix assembly (GO:0085029)4.14809778
44bone trabecula formation (GO:0060346)4.12130320
45hypotonic response (GO:0006971)4.10313363
46protein neddylation (GO:0045116)4.07590676
47substrate-dependent cell migration (GO:0006929)4.03798340
48response to ATP (GO:0033198)4.03667735
49type B pancreatic cell proliferation (GO:0044342)4.02194507
50pericardium development (GO:0060039)3.96171271
51negative regulation of fibroblast apoptotic process (GO:2000270)3.91781844
52membrane repolarization (GO:0086009)3.86488739
53negative regulation of hormone biosynthetic process (GO:0032353)3.84752526
54aggressive behavior (GO:0002118)3.84503093
55adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.83745290
56peristalsis (GO:0030432)3.82321687
57enteric nervous system development (GO:0048484)3.75401784
58cell communication involved in cardiac conduction (GO:0086065)3.74740648
59positive regulation of synaptic transmission, GABAergic (GO:0032230)3.72898351
60cellular response to prostaglandin stimulus (GO:0071379)3.72634658
61action potential (GO:0001508)3.71314325
62regulation of sensory perception (GO:0051931)3.70629069
63regulation of sensory perception of pain (GO:0051930)3.70629069
64positive regulation of osteoblast proliferation (GO:0033690)3.70609509
65regulation of histone phosphorylation (GO:0033127)3.68535731
66positive regulation of astrocyte differentiation (GO:0048711)3.67506460
67positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.66873204
68negative regulation of hormone metabolic process (GO:0032351)3.64518709
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.64012171
70muscle cell migration (GO:0014812)3.62535335
71regulation of glucocorticoid metabolic process (GO:0031943)3.61648590
72regulation of homotypic cell-cell adhesion (GO:0034110)3.57339578
73positive regulation of cardiac muscle hypertrophy (GO:0010613)3.55882894
74positive regulation of muscle hypertrophy (GO:0014742)3.55882894
75apoptotic cell clearance (GO:0043277)3.54977955
76response to water (GO:0009415)3.53552535
77positive regulation of Rho protein signal transduction (GO:0035025)3.52701980
78piRNA metabolic process (GO:0034587)3.47700151
79cytokine production involved in immune response (GO:0002367)3.47659053
80collagen fibril organization (GO:0030199)3.47616731
81mesenchymal-epithelial cell signaling (GO:0060638)3.47595841
82neuron fate specification (GO:0048665)3.44031168
83regulation of response to osmotic stress (GO:0047484)3.40975002
84collagen metabolic process (GO:0032963)3.39415033
85sequestering of actin monomers (GO:0042989)3.38681839
86negative regulation of smooth muscle cell migration (GO:0014912)3.38162274
87cornea development in camera-type eye (GO:0061303)3.37193362
88interleukin-6-mediated signaling pathway (GO:0070102)3.36123098
89collagen catabolic process (GO:0030574)3.35914063
90multicellular organismal catabolic process (GO:0044243)3.35375733
91cell migration in hindbrain (GO:0021535)3.34780738
92multicellular organismal macromolecule metabolic process (GO:0044259)3.32831413
93cellular response to nutrient (GO:0031670)3.31882475
94regulation of smooth muscle cell migration (GO:0014910)3.31356220
95actin filament capping (GO:0051693)3.27384523
96retinal ganglion cell axon guidance (GO:0031290)3.26855140
97regulation of glomerular filtration (GO:0003093)3.26627106
98respiratory burst (GO:0045730)3.26536384
99regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.24454432
100negative regulation of actin filament polymerization (GO:0030837)3.24028338
101membrane budding (GO:0006900)3.23119524
102dopamine receptor signaling pathway (GO:0007212)3.22977160
103lung morphogenesis (GO:0060425)3.19887883
104multicellular organismal metabolic process (GO:0044236)3.19335722
105cellular response to hepatocyte growth factor stimulus (GO:0035729)3.17665680
106response to hepatocyte growth factor (GO:0035728)3.17665680
107intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)3.16167229
108phosphatidylglycerol biosynthetic process (GO:0006655)3.13923423
109positive regulation of cell size (GO:0045793)3.13879410
110cell migration involved in heart development (GO:0060973)3.13652755
111axon cargo transport (GO:0008088)3.13108437
112negative regulation of protein polymerization (GO:0032272)3.12737969
113organ induction (GO:0001759)3.09526019
114phospholipid scrambling (GO:0017121)3.08061530
115polarized epithelial cell differentiation (GO:0030859)3.07513242
116maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.07447599
117establishment of apical/basal cell polarity (GO:0035089)3.07388700
118negative regulation of microtubule polymerization (GO:0031115)3.07187609
119positive regulation of Cdc42 GTPase activity (GO:0043089)3.06767940
120fibrinolysis (GO:0042730)3.06644797
121positive regulation of endothelial cell apoptotic process (GO:2000353)3.05256059
122COPI coating of Golgi vesicle (GO:0048205)3.04425168
123Golgi transport vesicle coating (GO:0048200)3.04425168
124negative regulation of meiosis (GO:0045835)3.03488142
125mammary gland epithelial cell proliferation (GO:0033598)3.02152016
126positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.01381944
127positive regulation of amino acid transport (GO:0051957)2.98127932
128vesicle transport along microtubule (GO:0047496)2.96746341
129regulation of collateral sprouting (GO:0048670)2.96374060
130hyaluronan catabolic process (GO:0030214)2.94270772
131sodium ion transmembrane transport (GO:0035725)2.94073335
132sensory perception of taste (GO:0050909)2.93254899
133ribonucleoprotein complex disassembly (GO:0032988)2.92435370
134anterior/posterior axis specification, embryo (GO:0008595)2.91656002
135cellular response to nicotine (GO:0071316)2.91279382
136regulation of actin filament depolymerization (GO:0030834)2.90698006
137extracellular fibril organization (GO:0043206)2.88287537
138positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.87951882
139extracellular matrix disassembly (GO:0022617)2.87922507
140DNA damage induced protein phosphorylation (GO:0006975)2.86855913
141alanine transport (GO:0032328)2.84746997
142stress fiber assembly (GO:0043149)2.83781047
143renal system process involved in regulation of blood volume (GO:0001977)2.83586224
144protein retention in ER lumen (GO:0006621)2.81499739
145positive regulation of cellular amide metabolic process (GO:0034250)2.81499196
146wound healing, spreading of epidermal cells (GO:0035313)2.80609299
147deoxyribose phosphate biosynthetic process (GO:0046385)2.80445639
1482-deoxyribonucleotide biosynthetic process (GO:0009265)2.80445639
149regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.78882567
150chronic inflammatory response (GO:0002544)2.77293833
151negative regulation of actin filament depolymerization (GO:0030835)2.77034990
152acrosome reaction (GO:0007340)2.75999674
153regulation of osteoblast proliferation (GO:0033688)2.75325535
154regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.75073620
155negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.74803506
156barbed-end actin filament capping (GO:0051016)2.74684223
157negative regulation of osteoblast proliferation (GO:0033689)2.73848611
158neuromuscular synaptic transmission (GO:0007274)2.72995458
159regulation of cell maturation (GO:1903429)2.71613186
160sensory perception of pain (GO:0019233)2.71263014
161heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.71031427
162substrate adhesion-dependent cell spreading (GO:0034446)2.70353283
163basement membrane organization (GO:0071711)2.69744278
164microtubule polymerization or depolymerization (GO:0031109)2.69379209
165fibril organization (GO:0097435)2.68950370
166regulation of integrin-mediated signaling pathway (GO:2001044)2.66933181
167production of molecular mediator of immune response (GO:0002440)2.66143773
168cerebral cortex neuron differentiation (GO:0021895)2.66121309
169negative regulation of sodium ion transport (GO:0010766)2.65826567
170positive regulation of alpha-beta T cell proliferation (GO:0046641)2.63472581
171positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.62958342
172positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.61627238
173regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.61627238
174regulation of collagen metabolic process (GO:0010712)2.60900514
175regulation of steroid hormone biosynthetic process (GO:0090030)2.60634350
176embryonic foregut morphogenesis (GO:0048617)2.60425289
177male meiosis (GO:0007140)2.60304822
178response to magnesium ion (GO:0032026)2.60147863
179regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.59333368
180embryo implantation (GO:0007566)2.59188755
181DNA methylation involved in gamete generation (GO:0043046)2.59070154
182decidualization (GO:0046697)2.58997825
183protein localization to endosome (GO:0036010)2.58573075
184negative regulation of axon extension involved in axon guidance (GO:0048843)2.58404469
185positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.56615202
186tooth mineralization (GO:0034505)2.56514290
187planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56278546
188glycosphingolipid biosynthetic process (GO:0006688)2.55086721
189smooth muscle tissue development (GO:0048745)2.55026159
190establishment of mitochondrion localization (GO:0051654)2.53502318
191venous blood vessel morphogenesis (GO:0048845)2.52266326
192wound healing (GO:0042060)2.52007415
193regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.51499916
194cellular response to interferon-alpha (GO:0035457)2.49775333
195response to vitamin D (GO:0033280)2.49346501
196positive regulation of blood vessel endothelial cell migration (GO:0043536)2.47564444
197negative regulation of stem cell proliferation (GO:2000647)2.46943348
198positive regulation of receptor recycling (GO:0001921)2.46391497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.95055048
2VDR_22108803_ChIP-Seq_LS180_Human4.66093805
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.27963174
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.64044195
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.49408958
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.46770586
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.23001699
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.21844554
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.21844554
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.21844554
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.93127325
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.88533718
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.86812829
14TCF4_18268006_ChIP-ChIP_LS174T_Human2.78891537
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.74284317
16ZNF263_19887448_ChIP-Seq_K562_Human2.72558597
17BRD4_25478319_ChIP-Seq_HGPS_Human2.70946539
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.68217529
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.65645240
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.56894628
21CLOCK_20551151_ChIP-Seq_293T_Human2.45411354
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.33827061
23CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.33625286
24CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.29637150
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.28347509
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27105104
27TP53_18474530_ChIP-ChIP_U2OS_Human2.26945739
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25048467
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24954726
30EP300_21415370_ChIP-Seq_HL-1_Mouse2.22587989
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.20102454
32IGF1R_20145208_ChIP-Seq_DFB_Human2.14570172
33PPAR_26484153_Chip-Seq_NCI-H1993_Human2.12272732
34TP53_16413492_ChIP-PET_HCT116_Human2.02993992
35GATA2_21666600_ChIP-Seq_HMVEC_Human2.02309391
36SALL1_21062744_ChIP-ChIP_HESCs_Human2.00172965
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.99001743
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.99001743
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.92334579
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.92180402
41JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90580143
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88770381
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.81451133
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79390499
45JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77535609
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77087855
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.75776426
48STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.70336630
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.69129736
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63125018
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62230073
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62230073
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62010357
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62010357
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61511063
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58897840
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58528202
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53875204
59SMC1_22415368_ChIP-Seq_MEFs_Mouse1.52720253
60PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.51262246
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51145566
62E2F7_22180533_ChIP-Seq_HELA_Human1.49521311
63TP53_22127205_ChIP-Seq_IMR90_Human1.49514886
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48955286
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.47479073
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46349302
67NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45877904
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45227070
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.44899295
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.41834877
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.41817174
72GBX2_23144817_ChIP-Seq_PC3_Human1.41583829
73STAT3_23295773_ChIP-Seq_U87_Human1.41473599
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.40759244
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.39517972
76* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36570552
77KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36411650
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35488111
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35221736
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.33922257
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.33020868
82TP63_17297297_ChIP-ChIP_HaCaT_Human1.32761184
83ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31072290
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30992045
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28790733
86SOX2_20726797_ChIP-Seq_SW620_Human1.28373309
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27249919
88SMAD3_21741376_ChIP-Seq_ESCs_Human1.26888134
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26722249
90KDM2B_26808549_Chip-Seq_REH_Human1.26390014
91SA1_22415368_ChIP-Seq_MEFs_Mouse1.26254600
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25366247
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25169954
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22984252
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21809290
96* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19567153
97NANOG_19829295_ChIP-Seq_ESCs_Human1.19254863
98SOX2_19829295_ChIP-Seq_ESCs_Human1.19254863
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18699589
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17979981
101JUN_21703547_ChIP-Seq_K562_Human1.17969536
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16840620
103MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16446171
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16246215
105STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15893796
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15642372
107GATA3_21867929_ChIP-Seq_TH1_Mouse1.14806436
108FOXM1_23109430_ChIP-Seq_U2OS_Human1.13514805
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13271514
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12884678
111SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12689645
112TCF4_23295773_ChIP-Seq_U87_Human1.12280966
113RNF2_27304074_Chip-Seq_NSC_Mouse1.11888244
114P300_19829295_ChIP-Seq_ESCs_Human1.11788591
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11453825
116REST_21632747_ChIP-Seq_MESCs_Mouse1.09946637
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.09863377
118TET1_21490601_ChIP-Seq_MESCs_Mouse1.08520370
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07042046
120VDR_24787735_ChIP-Seq_THP-1_Human1.05751277
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05714210
122MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05638911
123* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04786690
124* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04262794
125HTT_18923047_ChIP-ChIP_STHdh_Human1.04130195
126AHR_22903824_ChIP-Seq_MCF-7_Human1.03127926
127TBX20_22080862_ChIP-Seq_HEART_Mouse1.03018473
128TBX20_22328084_ChIP-Seq_HEART_Mouse1.03018473
129CDX2_22108803_ChIP-Seq_LS180_Human1.01374492
130EED_16625203_ChIP-ChIP_MESCs_Mouse1.00811118
131TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.00684056
132* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00480441
133TP63_23658742_ChIP-Seq_EP156T_Human0.99829319
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99135296
135* E2F1_18555785_Chip-Seq_ESCs_Mouse0.98186561
136NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96739642
137CJUN_26792858_Chip-Seq_BT549_Human0.96533024
138TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95001931
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94313242
140TCF4_22108803_ChIP-Seq_LS180_Human0.94059631
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92722434
142EGR1_19032775_ChIP-ChIP_M12_Human0.92113684
143* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92052927
144* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91170292
145KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90183486
146RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89980891
147SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89979063
148* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89699744
149SOX2_21211035_ChIP-Seq_LN229_Gbm0.89558894
150AR_25329375_ChIP-Seq_VCAP_Human0.89557642
151* SMAD3_21741376_ChIP-Seq_HESCs_Human0.89323817
152EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89181944
153GATA3_24758297_ChIP-Seq_MCF-7_Human0.88739524
154CBX2_22325352_ChIP-Seq_293T-Rex_Human0.88430406
155SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88249950
156SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86500853
157SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86142125
158ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86136999
159IRF8_27001747_Chip-Seq_BMDM_Mouse0.86111543
160KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85488112
161P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85434473
162* TAL1_26923725_Chip-Seq_HPCs_Mouse0.85223658
163TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85105700
164CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84899533
165ETV1_20927104_ChIP-Seq_GIST48_Human0.84854033
166NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84642381
167* CMYC_18555785_Chip-Seq_ESCs_Mouse0.84625789
168ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83400755
169CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83267716
170PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.83045907
171NANOG_18692474_ChIP-Seq_MESCs_Mouse0.82703403
172HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82567752
173LXR_22158963_ChIP-Seq_LIVER_Mouse0.81307745
174NANOG_16518401_ChIP-PET_MESCs_Mouse0.80959506
175TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.80944968
176TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80526262
177TP53_23651856_ChIP-Seq_MEFs_Mouse0.80264131
178TP53_22573176_ChIP-Seq_HFKS_Human0.80097293
179PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79203950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception9.16430129
2MP0002736_abnormal_nociception_after9.06269880
3MP0008438_abnormal_cutaneous_collagen6.93768168
4* MP0002735_abnormal_chemical_nociception6.65958322
5* MP0002733_abnormal_thermal_nociception4.41637190
6MP0003279_aneurysm4.07508632
7MP0004858_abnormal_nervous_system3.99122580
8MP0004270_analgesia3.96398767
9* MP0002734_abnormal_mechanical_nocicepti3.77360185
10MP0003705_abnormal_hypodermis_morpholog3.75496866
11* MP0001970_abnormal_pain_threshold3.56953693
12MP0005257_abnormal_intraocular_pressure3.40094240
13MP0004272_abnormal_basement_membrane3.25912276
14MP0001542_abnormal_bone_strength3.04664821
15MP0006276_abnormal_autonomic_nervous2.87774342
16MP0003693_abnormal_embryo_hatching2.80854560
17MP0005275_abnormal_skin_tensile2.80718907
18MP0001958_emphysema2.65347437
19MP0008004_abnormal_stomach_pH2.49109414
20MP0006054_spinal_hemorrhage2.23688234
21MP0003091_abnormal_cell_migration2.22175775
22MP0010368_abnormal_lymphatic_system2.21977689
23MP0000751_myopathy2.21146168
24MP0003656_abnormal_erythrocyte_physiolo2.19114494
25MP0005503_abnormal_tendon_morphology2.18540489
26MP0008260_abnormal_autophagy2.16184637
27MP0005360_urolithiasis2.05969485
28MP0003950_abnormal_plasma_membrane2.05343538
29MP0002751_abnormal_autonomic_nervous2.04569759
30MP0003448_altered_tumor_morphology2.00539501
31MP0009780_abnormal_chondrocyte_physiolo1.99452914
32MP0002877_abnormal_melanocyte_morpholog1.97018189
33MP0005623_abnormal_meninges_morphology1.93008291
34MP0009840_abnormal_foam_cell1.88380756
35MP0005164_abnormal_response_to1.78880455
36MP0005023_abnormal_wound_healing1.76727403
37MP0002295_abnormal_pulmonary_circulatio1.72866289
38MP0002896_abnormal_bone_mineralization1.70902314
39MP0009384_cardiac_valve_regurgitation1.69913985
40MP0000767_abnormal_smooth_muscle1.67366892
41MP0000858_altered_metastatic_potential1.65810673
42MP0010234_abnormal_vibrissa_follicle1.61104535
43MP0005508_abnormal_skeleton_morphology1.58990812
44MP0003300_gastrointestinal_ulcer1.57769793
45MP0010030_abnormal_orbit_morphology1.57348070
46MP0003941_abnormal_skin_development1.53761868
47MP0001348_abnormal_lacrimal_gland1.53504538
48MP0005083_abnormal_biliary_tract1.51320445
49MP0002272_abnormal_nervous_system1.49745177
50MP0003436_decreased_susceptibility_to1.48446403
51MP0001533_abnormal_skeleton_physiology1.42623774
52MP0003136_yellow_coat_color1.38276638
53* MP0002067_abnormal_sensory_capabilities1.37293407
54MP0008789_abnormal_olfactory_epithelium1.36961799
55MP0005390_skeleton_phenotype1.36355715
56MP0001270_distended_abdomen1.35207616
57MP0000372_irregular_coat_pigmentation1.34870275
58MP0005595_abnormal_vascular_smooth1.34730636
59MP0002998_abnormal_bone_remodeling1.32589162
60MP0008877_abnormal_DNA_methylation1.31605751
61MP0003123_paternal_imprinting1.29493851
62MP0000428_abnormal_craniofacial_morphol1.25936914
63MP0005197_abnormal_uvea_morphology1.25864158
64MP0002254_reproductive_system_inflammat1.24395606
65MP0002184_abnormal_innervation1.23617196
66MP0000569_abnormal_digit_pigmentation1.23504982
67MP0000343_altered_response_to1.23294830
68MP0010352_gastrointestinal_tract_polyps1.20340081
69MP0001299_abnormal_eye_distance/1.19001166
70MP0001243_abnormal_dermal_layer1.18422242
71MP0010771_integument_phenotype1.17308679
72* MP0001986_abnormal_taste_sensitivity1.14460311
73MP0002060_abnormal_skin_morphology1.10694592
74MP0000750_abnormal_muscle_regeneration1.08547719
75MP0001664_abnormal_digestion1.06209572
76MP0009697_abnormal_copulation1.05658362
77MP0005058_abnormal_lysosome_morphology1.05031705
78MP0006082_CNS_inflammation1.04784783
79MP0000579_abnormal_nail_morphology1.03524869
80MP0000538_abnormal_urinary_bladder1.02863667
81MP0004510_myositis1.02486263
82MP0003283_abnormal_digestive_organ1.02429849
83MP0008932_abnormal_embryonic_tissue1.02068611
84MP0000733_abnormal_muscle_development1.01678303
85MP0005394_taste/olfaction_phenotype0.95684267
86MP0005499_abnormal_olfactory_system0.95684267
87MP0009053_abnormal_anal_canal0.95367966
88MP0000955_abnormal_spinal_cord0.93745476
89MP0002933_joint_inflammation0.93363359
90MP0004957_abnormal_blastocyst_morpholog0.93241920
91MP0010155_abnormal_intestine_physiology0.92688835
92MP0004883_abnormal_blood_vessel0.91859354
93MP0003718_maternal_effect0.91066267
94MP0009250_abnormal_appendicular_skeleto0.90615308
95MP0005464_abnormal_platelet_physiology0.90303615
96MP0003385_abnormal_body_wall0.90273022
97MP0000427_abnormal_hair_cycle0.89952938
98MP0005085_abnormal_gallbladder_physiolo0.89640763
99MP0001849_ear_inflammation0.89117745
100MP0002089_abnormal_postnatal_growth/wei0.89099739
101MP0000534_abnormal_ureter_morphology0.88858343
102MP0000627_abnormal_mammary_gland0.87566350
103MP0003868_abnormal_feces_composition0.87031807
104MP0002177_abnormal_outer_ear0.83588227
105MP0000462_abnormal_digestive_system0.83576257
106MP0001881_abnormal_mammary_gland0.83032615
107MP0002876_abnormal_thyroid_physiology0.81535447
108MP0002128_abnormal_blood_circulation0.80394516
109MP0000762_abnormal_tongue_morphology0.80298353
110MP0003183_abnormal_peptide_metabolism0.79460229
111* MP0004811_abnormal_neuron_physiology0.79084910
112MP0001879_abnormal_lymphatic_vessel0.78207960
113MP0001614_abnormal_blood_vessel0.76632673
114MP0000490_abnormal_crypts_of0.76346577
115MP0003795_abnormal_bone_structure0.75846072
116MP0004859_abnormal_synaptic_plasticity0.75750518
117MP0001915_intracranial_hemorrhage0.75149468
118MP0003045_fibrosis0.74989760
119MP0001666_abnormal_nutrient_absorption0.74257232
120MP0010307_abnormal_tumor_latency0.72469312
121MP0002113_abnormal_skeleton_development0.72245843
122MP0000249_abnormal_blood_vessel0.71796280
123MP0002108_abnormal_muscle_morphology0.71336281
124MP0005408_hypopigmentation0.69501197
125MP0000477_abnormal_intestine_morphology0.69146387
126MP0005381_digestive/alimentary_phenotyp0.68926637
127MP0000163_abnormal_cartilage_morphology0.67835823
128MP0001663_abnormal_digestive_system0.67622085
129MP0003806_abnormal_nucleotide_metabolis0.66765875
130MP0002160_abnormal_reproductive_system0.66314329
131MP0003566_abnormal_cell_adhesion0.65039136
132MP0000432_abnormal_head_morphology0.64565517
133MP0000604_amyloidosis0.63984316
134MP0003942_abnormal_urinary_system0.63975551
135MP0008775_abnormal_heart_ventricle0.62429258
136MP0009046_muscle_twitch0.61782608
137MP0000015_abnormal_ear_pigmentation0.61061223
138MP0004084_abnormal_cardiac_muscle0.60690674
139MP0000681_abnormal_thyroid_gland0.60028781
140MP0000013_abnormal_adipose_tissue0.59391748
141MP0003936_abnormal_reproductive_system0.58950739
142MP0003646_muscle_fatigue0.57961320
143MP0001727_abnormal_embryo_implantation0.57630121
144MP0002163_abnormal_gland_morphology0.56905884
145MP0005165_increased_susceptibility_to0.56010327
146MP0005451_abnormal_body_composition0.55027790
147MP0005367_renal/urinary_system_phenotyp0.54826939
148MP0000516_abnormal_urinary_system0.54826939
149MP0004484_altered_response_of0.53812065
150MP0001346_abnormal_lacrimal_gland0.51885470
151MP0003315_abnormal_perineum_morphology0.51384241
152MP0005395_other_phenotype0.50828119
153MP0003634_abnormal_glial_cell0.50313530
154MP0002653_abnormal_ependyma_morphology0.47927333
155MP0008872_abnormal_physiological_respon0.44840127
156MP0003077_abnormal_cell_cycle0.44546183
157MP0010094_abnormal_chromosome_stability0.44446544
158MP0002882_abnormal_neuron_morphology0.44138845
159MP0003724_increased_susceptibility_to0.43979386
160MP0002210_abnormal_sex_determination0.43115957
161MP0010386_abnormal_urinary_bladder0.39757478
162MP0003699_abnormal_female_reproductive0.39570119
163MP0001188_hyperpigmentation0.39252479
164MP0003329_amyloid_beta_deposits0.38915439
165MP0000653_abnormal_sex_gland0.38847427
166MP0001905_abnormal_dopamine_level0.36114022
167MP0001119_abnormal_female_reproductive0.36038566
168MP0000778_abnormal_nervous_system0.35896032
169MP0001929_abnormal_gametogenesis0.35247593
170MP0004036_abnormal_muscle_relaxation0.35057867
171MP0004142_abnormal_muscle_tone0.34251238
172MP0002102_abnormal_ear_morphology0.34103801
173MP0002752_abnormal_somatic_nervous0.33841276
174MP0005166_decreased_susceptibility_to0.31843300
175MP0008058_abnormal_DNA_repair0.30769364
176MP0003453_abnormal_keratinocyte_physiol0.30497313
177MP0003632_abnormal_nervous_system0.30394774
178MP0005389_reproductive_system_phenotype0.30198209
179MP0002873_normal_phenotype0.30189332
180MP0005310_abnormal_salivary_gland0.30028671
181MP0003186_abnormal_redox_activity0.29420547
182MP0002169_no_abnormal_phenotype0.29193601
183MP0009785_altered_susceptibility_to0.28194475
184MP0009764_decreased_sensitivity_to0.28135506
185* MP0003631_nervous_system_phenotype0.28100628

Predicted human phenotypes

RankGene SetZ-score
1Dysautonomia (HP:0002459)7.88240205
2Ulnar claw (HP:0001178)7.19816426
3Premature rupture of membranes (HP:0001788)6.97860869
4Follicular hyperkeratosis (HP:0007502)5.89337251
5Protrusio acetabuli (HP:0003179)5.79240110
6Ankle contracture (HP:0006466)5.76830587
7Impaired pain sensation (HP:0007328)5.73599987
8Abnormality of pain sensation (HP:0010832)5.73599987
9Aortic dissection (HP:0002647)5.48025863
10Type 1 muscle fiber predominance (HP:0003803)5.39168482
11Termporal pattern (HP:0011008)5.37492127
12Insidious onset (HP:0003587)5.37492127
13Aortic aneurysm (HP:0004942)5.29679755
14Vascular tortuosity (HP:0004948)5.22422197
15Segmental peripheral demyelination/remyelination (HP:0003481)5.12683479
16Arterial tortuosity (HP:0005116)4.89742059
17Slender build (HP:0001533)4.56188576
18Abnormal autonomic nervous system physiology (HP:0012332)4.43289028
19Soft skin (HP:0000977)4.15593966
20Bladder diverticulum (HP:0000015)4.03125542
21Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.01896994
22Axonal loss (HP:0003447)3.79506512
23Abnormality of dentin (HP:0010299)3.62498242
24Spinal rigidity (HP:0003306)3.62493968
25Atrophic scars (HP:0001075)3.62284057
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.44436255
27Action tremor (HP:0002345)3.42699425
28Genu recurvatum (HP:0002816)3.34488625
29Hammertoe (HP:0001765)3.29355375
30Mildly elevated creatine phosphokinase (HP:0008180)3.26708450
31Hypothermia (HP:0002045)3.23475881
32Thyroid carcinoma (HP:0002890)3.20455810
33Wormian bones (HP:0002645)3.20412081
34Peripheral demyelination (HP:0011096)3.19330830
35Peritonitis (HP:0002586)3.18599878
36Thoracolumbar scoliosis (HP:0002944)3.17570692
37Achilles tendon contracture (HP:0001771)3.14750848
38Fragile skin (HP:0001030)3.14354940
39Dilatation of the ascending aorta (HP:0005111)3.12917023
40Cervical subluxation (HP:0003308)3.12342717
41Blue sclerae (HP:0000592)3.09775999
42Abnormal umbilical cord blood vessels (HP:0011403)3.05397457
43Single umbilical artery (HP:0001195)3.05397457
44Abnormality of the fetal cardiovascular system (HP:0010948)3.05397457
45Upper limb muscle weakness (HP:0003484)3.02777779
46Myokymia (HP:0002411)3.01379333
47Mitral valve prolapse (HP:0001634)2.99039040
48Spondylolisthesis (HP:0003302)2.99030462
49Overgrowth (HP:0001548)2.94853743
50Vertebral compression fractures (HP:0002953)2.94515595
51Abnormality of magnesium homeostasis (HP:0004921)2.93132866
52Elbow flexion contracture (HP:0002987)2.91692919
53Steppage gait (HP:0003376)2.88448322
54Increased variability in muscle fiber diameter (HP:0003557)2.87477543
55Abnormality of the Achilles tendon (HP:0005109)2.86367362
56Broad metatarsal (HP:0001783)2.85725643
57Failure to thrive in infancy (HP:0001531)2.85548678
58Cerebral aneurysm (HP:0004944)2.82779319
59Submucous cleft hard palate (HP:0000176)2.82724229
60Hydroureter (HP:0000072)2.81768179
61Neuroblastic tumors (HP:0004376)2.81559420
62Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.81559420
63Neuroblastoma (HP:0003006)2.81559420
64Primitive neuroectodermal tumor (HP:0030065)2.81559420
65Peripheral hypomyelination (HP:0007182)2.79382011
66Abnormality of proline metabolism (HP:0010907)2.74641574
67Hydroxyprolinuria (HP:0003080)2.74641574
68Distal arthrogryposis (HP:0005684)2.74406003
69Hypomagnesemia (HP:0002917)2.73864771
70Neonatal short-limb short stature (HP:0008921)2.72787299
71Ventricular fibrillation (HP:0001663)2.71578797
72Aneurysm (HP:0002617)2.71108648
73Overlapping toe (HP:0001845)2.68273697
74Wide anterior fontanel (HP:0000260)2.66894046
75Joint laxity (HP:0001388)2.63944560
76Hypoventilation (HP:0002791)2.60483909
77Distal lower limb muscle weakness (HP:0009053)2.58134299
78Distal sensory impairment (HP:0002936)2.57414569
79Decreased motor nerve conduction velocity (HP:0003431)2.57387493
80Onion bulb formation (HP:0003383)2.56384514
81Foot dorsiflexor weakness (HP:0009027)2.51725228
82Potter facies (HP:0002009)2.46631623
83Facial shape deformation (HP:0011334)2.46631623
84Autoimmune thrombocytopenia (HP:0001973)2.46587305
85Abnormality of skeletal muscle fiber size (HP:0012084)2.46435728
86Long toe (HP:0010511)2.46301350
87Abnormality of glutamine family amino acid metabolism (HP:0010902)2.44180521
88Ankle clonus (HP:0011448)2.44132950
89Abnormality of the vocal cords (HP:0008777)2.42136996
90Hyperextensible skin (HP:0000974)2.42126649
91Hypercortisolism (HP:0001578)2.41414427
92Abnormality of the aortic arch (HP:0012303)2.39412159
93Bowel diverticulosis (HP:0005222)2.39211415
94Abnormality of the umbilical cord (HP:0010881)2.34666248
95Neuroendocrine neoplasm (HP:0100634)2.34021427
96Aqueductal stenosis (HP:0002410)2.33290564
97Eczematoid dermatitis (HP:0000976)2.33058700
98Cortical dysplasia (HP:0002539)2.31823388
99Pheochromocytoma (HP:0002666)2.31158207
100Wrist flexion contracture (HP:0001239)2.31107951
101Chromsome breakage (HP:0040012)2.29153890
102Bradycardia (HP:0001662)2.23583305
103Abnormality of pyrimidine metabolism (HP:0004353)2.23241956
104Atonic seizures (HP:0010819)2.22105228
105Distal upper limb amyotrophy (HP:0007149)2.20680222
106Upper limb amyotrophy (HP:0009129)2.20680222
107Abnormal hair whorl (HP:0010721)2.19527060
108Muscle fibrillation (HP:0010546)2.18918334
109Abnormality of the foot musculature (HP:0001436)2.18535387
110Neoplasm of the adrenal cortex (HP:0100641)2.17794654
111Generalized amyotrophy (HP:0003700)2.17686103
112Abnormality of the anterior horn cell (HP:0006802)2.17138382
113Degeneration of anterior horn cells (HP:0002398)2.17138382
114Areflexia of lower limbs (HP:0002522)2.16190519
115Shallow orbits (HP:0000586)2.14956332
116Autoamputation (HP:0001218)2.14955158
117Osteolytic defects of the hand bones (HP:0009699)2.13762236
118Osteolytic defects of the phalanges of the hand (HP:0009771)2.13762236
119Abnormality of the corticospinal tract (HP:0002492)2.12708887
120Impaired proprioception (HP:0010831)2.12313722
121Redundant skin (HP:0001582)2.12175795
122Hand muscle atrophy (HP:0009130)2.11882889
123Carpal bone hypoplasia (HP:0001498)2.09990934
124Ovoid vertebral bodies (HP:0003300)2.07396453
125Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07390661
126Malnutrition (HP:0004395)2.07099711
127Protruding ear (HP:0000411)2.07007500
128Hypophosphatemic rickets (HP:0004912)2.05609841
129Abnormality of the acetabulum (HP:0003170)2.05154656
130Menorrhagia (HP:0000132)2.03001503
131Limb-girdle muscle weakness (HP:0003325)2.02959099
132Disproportionate tall stature (HP:0001519)2.02749111
133Xerostomia (HP:0000217)1.97891357
134Cardiovascular calcification (HP:0011915)1.97083159
135Tetraparesis (HP:0002273)1.95703262
136Nausea (HP:0002018)1.94563711
137Abnormality of the pulmonary veins (HP:0011718)1.94543794
138Focal seizures (HP:0007359)1.93947814
139Intestinal atresia (HP:0011100)1.93837463
140Absent phalangeal crease (HP:0006109)1.91805980
141Mesomelia (HP:0003027)1.91496873
142Obstructive sleep apnea (HP:0002870)1.91470822
143Femoral bowing (HP:0002980)1.91009262
144Episodic fever (HP:0001954)1.89590708
145Neonatal death (HP:0003811)1.89052209
146Abnormal delivery (HP:0001787)1.88897646
147Mask-like facies (HP:0000298)1.87914780
148Aortic regurgitation (HP:0001659)1.86576629
149Increased CSF protein (HP:0002922)1.85823537
150Lower limb amyotrophy (HP:0007210)1.85437684
151Cupped ribs (HP:0000887)1.84955931
152Microglossia (HP:0000171)1.82954877
153Abnormality of the musculature of the hand (HP:0001421)1.80982956
154Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80109698
155Premature skin wrinkling (HP:0100678)1.79855281
156Abnormality of the epiphysis of the femoral head (HP:0010574)1.79533723
157Mucopolysacchariduria (HP:0008155)1.79526138
158Urinary glycosaminoglycan excretion (HP:0003541)1.79526138
159Bicornuate uterus (HP:0000813)1.79400819
160Nervous tissue neoplasm (HP:0030060)1.76930500
161Neuroectodermal neoplasm (HP:0030061)1.76930500
162Neuroepithelial neoplasm (HP:0030063)1.76930500
163Osteopenia (HP:0000938)1.76879682
164Progressive sensorineural hearing impairment (HP:0000408)1.75956861
165Torticollis (HP:0000473)1.75484188
166Knee flexion contracture (HP:0006380)1.75235484
167Ankyloglossia (HP:0010296)1.74877870
168Abnormality of the labia minora (HP:0012880)1.74840471
169Dysostosis multiplex (HP:0000943)1.74345221
170Facial hemangioma (HP:0000329)1.74179810
171Cutaneous melanoma (HP:0012056)1.73871112
172Tongue fasciculations (HP:0001308)1.72852604
173Camptodactyly of toe (HP:0001836)1.72803053
174Increased corneal curvature (HP:0100692)1.69971805
175Keratoconus (HP:0000563)1.69971805
176Arthropathy (HP:0003040)1.69162018
177Biconcave vertebral bodies (HP:0004586)1.69156670
178Impaired platelet aggregation (HP:0003540)1.68424081
179Abnormal platelet function (HP:0011869)1.68424081
180Myotonia (HP:0002486)1.67495209
181Joint stiffness (HP:0001387)1.67404370
182Aplasia/Hypoplasia of the tibia (HP:0005772)1.67175913
183Arachnodactyly (HP:0001166)1.66770959
184Chin dimple (HP:0010751)1.66656730
185Adrenal hypoplasia (HP:0000835)1.65504901
186Febrile seizures (HP:0002373)1.65180301
187Abnormality of glycolipid metabolism (HP:0010969)1.64746646
188Abnormality of liposaccharide metabolism (HP:0010968)1.64746646
189Abnormality of glycosphingolipid metabolism (HP:0004343)1.64746646
190Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64598407
191Thin bony cortex (HP:0002753)1.64307707
192Abnormality of mucopolysaccharide metabolism (HP:0011020)1.63924111
193Abnormality of polysaccharide metabolism (HP:0011012)1.63924111
194Abnormality of glycosaminoglycan metabolism (HP:0004371)1.63924111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK5.32535213
2RIPK44.82715789
3MAP3K94.14899574
4KSR24.09214571
5PDGFRA4.02770695
6NTRK13.76856534
7GRK73.68185801
8FRK3.63221091
9MAP3K23.27262408
10LMTK23.14655380
11LIMK13.01439864
12ERN12.86348164
13GRK52.82796636
14TGFBR22.80044723
15ARAF2.71998196
16DDR22.68750452
17PIK3CG2.53625384
18GRK12.39684839
19PTK22.21737728
20GRK62.19735636
21PAK62.15633612
22MARK32.05514525
23EPHB22.03158869
24RIPK12.00003960
25LATS21.91431462
26EPHA31.86771934
27PAK21.82929528
28RET1.78810442
29MINK11.72902494
30PAK41.66127367
31TTN1.65285950
32MATK1.64194921
33BRAF1.63106896
34ACVR1B1.53949110
35NEK91.50266034
36IRAK31.49931359
37CDC42BPA1.49682861
38DAPK21.48061330
39TESK11.41546184
40AKT31.33486465
41PRKD31.30416209
42RPS6KA21.30263209
43MAP2K11.28387568
44PLK31.22714227
45ADRBK21.20594795
46PRKG21.15406329
47PRKD21.14814780
48PDGFRB1.14513294
49MAP2K21.11484045
50SIK11.08007298
51LATS11.03377713
52NTRK31.00396043
53MAP3K11.00255293
54YES10.99565366
55NEK10.98891125
56MAP3K130.98080180
57MAP3K120.97748824
58SCYL20.96444051
59BMPR20.96071434
60ZAP700.94932120
61PNCK0.92499373
62ABL20.90251176
63STK240.89998350
64ROCK10.89624433
65MST40.88715645
66EPHA20.88306309
67ERBB30.88282984
68DYRK1B0.84792757
69PKN20.84314327
70TRIB30.84269412
71ROCK20.81475116
72EIF2AK30.79883203
73FER0.79651044
74STK30.78873513
75PLK40.78815418
76MAP3K40.78528473
77MET0.78503466
78MOS0.78079217
79ZAK0.77534509
80CLK10.77205035
81KIT0.73970596
82STK380.73740178
83JAK30.72266933
84MAPK130.72246761
85MAP3K30.71323058
86TRPM70.71136346
87TAOK20.70922611
88FGFR30.69641671
89MAP3K50.69544026
90DAPK30.69499171
91DYRK20.68897003
92PLK20.68386591
93AURKA0.68156223
94GSK3A0.65284896
95SGK20.65108402
96MAP2K70.64385687
97ADRBK10.64372243
98TIE10.64360495
99CDK140.64097404
100CHUK0.63909836
101PAK10.63010721
102MAPKAPK30.62498460
103PTK2B0.61909809
104TYK20.61176012
105MAP3K80.61167064
106SGK4940.60092546
107SGK2230.60092546
108TTK0.59688184
109ALK0.58278775
110FGFR20.58036888
111PIM20.57683511
112DMPK0.56577961
113BCR0.55642744
114PLK10.55205937
115TSSK60.51207408
116PDPK10.49062495
117ILK0.48054793
118EIF2AK10.47483049
119RAF10.46908700
120PHKG20.45769819
121PHKG10.45769819
122MAPKAPK20.45539746
123KSR10.45451101
124PRKCZ0.45120667
125PDK10.45104658
126MAPK40.44683499
127IKBKE0.44025741
128EPHB10.43670141
129CDC70.43445833
130PAK30.42836219
131MAP3K140.42730865
132TBK10.41844114
133CDK90.40285455
134FGR0.38970136
135MELK0.38111380
136CSNK1E0.37671576
137FLT30.37186528
138JAK20.36776809
139BRSK10.34967257
140PRKCE0.34857508
141RPS6KB20.34682458
142MAP2K30.34631336
143SGK30.34598049
144MAP2K40.32633388
145CDK50.32340525
146BUB10.32233568
147ERBB40.31127249
148RPS6KB10.31106055
149IGF1R0.31019857
150NLK0.30696228
151CSNK2A20.30552245
152TGFBR10.28423934
153PRPF4B0.27895176
154ATM0.27516069
155JAK10.26708544
156PBK0.26388552
157SRC0.25941294
158FGFR40.25609433
159MUSK0.23581065
160MTOR0.23571943
161CAMK2G0.20506357
162INSR0.18910336
163CDK180.18096046
164PRKD10.18074085
165CDK150.17861132

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.33577892
2Renin-angiotensin system_Homo sapiens_hsa046143.21708423
3Thyroid cancer_Homo sapiens_hsa052163.14379400
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.99110500
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.89602404
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.71753761
7Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.64968328
8Focal adhesion_Homo sapiens_hsa045102.63367849
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.38509798
10Steroid biosynthesis_Homo sapiens_hsa001002.24016229
11Synaptic vesicle cycle_Homo sapiens_hsa047212.18939580
12Folate biosynthesis_Homo sapiens_hsa007902.08866292
13Proteoglycans in cancer_Homo sapiens_hsa052052.00853069
14Salmonella infection_Homo sapiens_hsa051321.99106850
15Complement and coagulation cascades_Homo sapiens_hsa046101.97969025
16Proteasome_Homo sapiens_hsa030501.88997748
17Other glycan degradation_Homo sapiens_hsa005111.87894469
18Regulation of actin cytoskeleton_Homo sapiens_hsa048101.82269470
19Sulfur metabolism_Homo sapiens_hsa009201.78945938
20Oocyte meiosis_Homo sapiens_hsa041141.73780549
21Phagosome_Homo sapiens_hsa041451.72014668
22Dorso-ventral axis formation_Homo sapiens_hsa043201.69963964
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.60912062
24Mineral absorption_Homo sapiens_hsa049781.59393380
25Small cell lung cancer_Homo sapiens_hsa052221.49706077
26Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.49044583
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48482633
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.47999825
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.47484777
30African trypanosomiasis_Homo sapiens_hsa051431.46941743
31Endometrial cancer_Homo sapiens_hsa052131.45586220
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43109816
33Malaria_Homo sapiens_hsa051441.40597385
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35411908
35GnRH signaling pathway_Homo sapiens_hsa049121.32553605
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28868830
37PI3K-Akt signaling pathway_Homo sapiens_hsa041511.28798691
38Lysosome_Homo sapiens_hsa041421.24171331
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23863984
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.22970491
41* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20275646
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19813686
43Melanoma_Homo sapiens_hsa052181.19179296
44Dilated cardiomyopathy_Homo sapiens_hsa054141.18250988
45Insulin secretion_Homo sapiens_hsa049111.17037876
46Chronic myeloid leukemia_Homo sapiens_hsa052201.14172486
47Ether lipid metabolism_Homo sapiens_hsa005651.13642050
48Prolactin signaling pathway_Homo sapiens_hsa049171.13434813
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11107009
50Taste transduction_Homo sapiens_hsa047421.09177286
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.07980576
52Gap junction_Homo sapiens_hsa045401.07613588
53Choline metabolism in cancer_Homo sapiens_hsa052311.05807523
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05186457
55Viral myocarditis_Homo sapiens_hsa054161.04723322
56Cell cycle_Homo sapiens_hsa041101.04548776
57Pathways in cancer_Homo sapiens_hsa052001.03384973
58Glycerophospholipid metabolism_Homo sapiens_hsa005641.03279122
59N-Glycan biosynthesis_Homo sapiens_hsa005101.02685658
60Sphingolipid signaling pathway_Homo sapiens_hsa040711.02306577
61Regulation of autophagy_Homo sapiens_hsa041401.01725662
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.00217513
63Amoebiasis_Homo sapiens_hsa051460.99619201
64MicroRNAs in cancer_Homo sapiens_hsa052060.99553158
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98490719
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.95351794
67Shigellosis_Homo sapiens_hsa051310.94846989
68mTOR signaling pathway_Homo sapiens_hsa041500.93669056
69Leishmaniasis_Homo sapiens_hsa051400.92732600
70Prostate cancer_Homo sapiens_hsa052150.92134357
71Glioma_Homo sapiens_hsa052140.91553839
72Galactose metabolism_Homo sapiens_hsa000520.90336921
73Estrogen signaling pathway_Homo sapiens_hsa049150.90054541
74Thyroid hormone synthesis_Homo sapiens_hsa049180.89928984
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.89461310
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85267837
77p53 signaling pathway_Homo sapiens_hsa041150.85232816
78Dopaminergic synapse_Homo sapiens_hsa047280.84136206
79Epstein-Barr virus infection_Homo sapiens_hsa051690.83489458
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83188617
81Rheumatoid arthritis_Homo sapiens_hsa053230.82704660
82Apoptosis_Homo sapiens_hsa042100.82554266
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79739864
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.78710002
85Platelet activation_Homo sapiens_hsa046110.78295905
86Legionellosis_Homo sapiens_hsa051340.77458846
87Hippo signaling pathway_Homo sapiens_hsa043900.77455816
88Renal cell carcinoma_Homo sapiens_hsa052110.76355902
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75009824
90Pertussis_Homo sapiens_hsa051330.73921055
91Allograft rejection_Homo sapiens_hsa053300.72105881
92Olfactory transduction_Homo sapiens_hsa047400.71909611
93Rap1 signaling pathway_Homo sapiens_hsa040150.71536367
94Bladder cancer_Homo sapiens_hsa052190.71535434
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70099523
96Cholinergic synapse_Homo sapiens_hsa047250.69776642
97Vitamin digestion and absorption_Homo sapiens_hsa049770.68790420
98Fat digestion and absorption_Homo sapiens_hsa049750.67758906
99Pancreatic cancer_Homo sapiens_hsa052120.66725596
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66366337
101Graft-versus-host disease_Homo sapiens_hsa053320.65522997
102Melanogenesis_Homo sapiens_hsa049160.65451172
103VEGF signaling pathway_Homo sapiens_hsa043700.65293814
104Tuberculosis_Homo sapiens_hsa051520.64782149
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64607157
106Hedgehog signaling pathway_Homo sapiens_hsa043400.63479523
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63298091
108Long-term potentiation_Homo sapiens_hsa047200.62783862
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62586874
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61867518
111Type II diabetes mellitus_Homo sapiens_hsa049300.61208382
112ErbB signaling pathway_Homo sapiens_hsa040120.60664399
113Insulin signaling pathway_Homo sapiens_hsa049100.59932827
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58377080
115Colorectal cancer_Homo sapiens_hsa052100.58336331
116Hematopoietic cell lineage_Homo sapiens_hsa046400.57705542
117Glutamatergic synapse_Homo sapiens_hsa047240.57399749
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56898146
119Glycerolipid metabolism_Homo sapiens_hsa005610.56817721
120TNF signaling pathway_Homo sapiens_hsa046680.56515322
121Hepatitis B_Homo sapiens_hsa051610.55801787
122PPAR signaling pathway_Homo sapiens_hsa033200.55532182
123Pancreatic secretion_Homo sapiens_hsa049720.54736262
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54715835
125Protein digestion and absorption_Homo sapiens_hsa049740.54286240
126Basal cell carcinoma_Homo sapiens_hsa052170.54022242
127Collecting duct acid secretion_Homo sapiens_hsa049660.53891592
128Fructose and mannose metabolism_Homo sapiens_hsa000510.53223101
129Sphingolipid metabolism_Homo sapiens_hsa006000.53161918
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52853200
131Long-term depression_Homo sapiens_hsa047300.52847349
132Tight junction_Homo sapiens_hsa045300.52288710
133Vibrio cholerae infection_Homo sapiens_hsa051100.51829536
134Glutathione metabolism_Homo sapiens_hsa004800.51508218
135Toxoplasmosis_Homo sapiens_hsa051450.51294335
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51278431
137Endocytosis_Homo sapiens_hsa041440.50878852
138Prion diseases_Homo sapiens_hsa050200.50762771
139Hepatitis C_Homo sapiens_hsa051600.49662371
140Salivary secretion_Homo sapiens_hsa049700.49616987
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.48353146
142Acute myeloid leukemia_Homo sapiens_hsa052210.46960372
143HTLV-I infection_Homo sapiens_hsa051660.46395309
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45615440
145TGF-beta signaling pathway_Homo sapiens_hsa043500.44726379
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44357066
147Osteoclast differentiation_Homo sapiens_hsa043800.44354321
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44250463
149Adherens junction_Homo sapiens_hsa045200.43426422
150Ras signaling pathway_Homo sapiens_hsa040140.43361389
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.43211652
152Serotonergic synapse_Homo sapiens_hsa047260.42589656
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42496428
154Protein export_Homo sapiens_hsa030600.41883222

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