TRPC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.18049325
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.79433818
3locomotory exploration behavior (GO:0035641)4.62968801
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56414983
5synaptic vesicle maturation (GO:0016188)4.50558973
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.46627295
7synaptic vesicle exocytosis (GO:0016079)4.45185148
8regulation of synaptic vesicle exocytosis (GO:2000300)4.36110187
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35765966
10vocalization behavior (GO:0071625)4.35440389
11neuronal action potential propagation (GO:0019227)4.26998029
12glutamate secretion (GO:0014047)4.25392170
13neuron cell-cell adhesion (GO:0007158)4.22808146
14protein localization to synapse (GO:0035418)4.17324306
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.13174098
16regulation of glutamate receptor signaling pathway (GO:1900449)3.99476780
17regulation of synaptic vesicle transport (GO:1902803)3.93491151
18synaptic transmission, glutamatergic (GO:0035249)3.92489447
19neuron-neuron synaptic transmission (GO:0007270)3.81661748
20presynaptic membrane assembly (GO:0097105)3.80645493
21glutamate receptor signaling pathway (GO:0007215)3.79112454
22regulation of neuronal synaptic plasticity (GO:0048168)3.69982076
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.65785125
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.57779669
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.57601001
26presynaptic membrane organization (GO:0097090)3.53789220
27exploration behavior (GO:0035640)3.53430238
28neurotransmitter secretion (GO:0007269)3.49922406
29transmission of nerve impulse (GO:0019226)3.49187150
30long-term synaptic potentiation (GO:0060291)3.47059477
31neuron recognition (GO:0008038)3.45267866
32positive regulation of membrane potential (GO:0045838)3.45078481
33dendritic spine morphogenesis (GO:0060997)3.42635940
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.41821426
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38150101
36long-term memory (GO:0007616)3.34645498
37protein targeting to Golgi (GO:0000042)3.32543898
38regulation of postsynaptic membrane potential (GO:0060078)3.29964279
39axonal fasciculation (GO:0007413)3.28075462
40establishment of protein localization to Golgi (GO:0072600)3.26769367
41neurotransmitter-gated ion channel clustering (GO:0072578)3.26763470
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.25476736
43protein polyglutamylation (GO:0018095)3.21602048
44regulation of neurotransmitter secretion (GO:0046928)3.19293642
45postsynaptic membrane organization (GO:0001941)3.18591458
46regulation of synapse structural plasticity (GO:0051823)3.16958590
47layer formation in cerebral cortex (GO:0021819)3.16314295
48regulation of synaptic plasticity (GO:0048167)3.14423629
49cellular potassium ion homeostasis (GO:0030007)3.10788893
50retrograde transport, vesicle recycling within Golgi (GO:0000301)3.07694169
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07571908
52gamma-aminobutyric acid transport (GO:0015812)3.07398594
53membrane hyperpolarization (GO:0060081)3.07289029
54regulation of vesicle fusion (GO:0031338)3.04934735
55neurotransmitter transport (GO:0006836)3.04602888
56negative regulation of neurotransmitter transport (GO:0051589)3.04279415
57innervation (GO:0060384)3.02696734
58regulation of dendritic spine morphogenesis (GO:0061001)3.02613799
59dendrite morphogenesis (GO:0048813)2.99545614
60negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99323256
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.98116981
62regulation of synaptic transmission, glutamatergic (GO:0051966)2.97775212
63regulation of neurotransmitter transport (GO:0051588)2.96861261
64chemosensory behavior (GO:0007635)2.90435325
65cerebral cortex radially oriented cell migration (GO:0021799)2.89984387
66regulation of voltage-gated calcium channel activity (GO:1901385)2.89690254
67neuronal ion channel clustering (GO:0045161)2.89438361
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.88363915
69cerebellar Purkinje cell differentiation (GO:0021702)2.85516654
70synaptic vesicle endocytosis (GO:0048488)2.85359885
71positive regulation of neurotransmitter transport (GO:0051590)2.85044454
72behavioral response to cocaine (GO:0048148)2.84855861
73synapse assembly (GO:0007416)2.83819920
74detection of calcium ion (GO:0005513)2.83521653
75sperm motility (GO:0030317)2.82721754
76activation of protein kinase A activity (GO:0034199)2.82570385
77response to histamine (GO:0034776)2.80914669
78axon extension involved in axon guidance (GO:0048846)2.80866040
79neuron projection extension involved in neuron projection guidance (GO:1902284)2.80866040
80behavioral defense response (GO:0002209)2.79992067
81behavioral fear response (GO:0001662)2.79992067
82cerebellar granule cell differentiation (GO:0021707)2.79951296
83proline transport (GO:0015824)2.79923267
84seminiferous tubule development (GO:0072520)2.79598296
85positive regulation of neurotransmitter secretion (GO:0001956)2.79164696
86fear response (GO:0042596)2.79119159
87membrane depolarization (GO:0051899)2.78954771
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78709027
89negative regulation of neurotransmitter secretion (GO:0046929)2.77520281
90learning (GO:0007612)2.77223507
91neurofilament cytoskeleton organization (GO:0060052)2.75786558
92positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75023242
93neuromuscular process controlling balance (GO:0050885)2.74676517
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73646141
95atrial cardiac muscle cell action potential (GO:0086014)2.71620655
96positive regulation of synaptic transmission (GO:0050806)2.70972890
97auditory behavior (GO:0031223)2.69486712
98membrane depolarization during action potential (GO:0086010)2.69296197
99startle response (GO:0001964)2.69206049
100synaptic transmission (GO:0007268)2.67458466
101synapse organization (GO:0050808)2.66549958
102protein localization to Golgi apparatus (GO:0034067)2.66453313
103cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.66322551
104striatum development (GO:0021756)2.66293295
105regulation of neurotransmitter levels (GO:0001505)2.66191607
106vesicle transport along microtubule (GO:0047496)2.65715348
107retinal ganglion cell axon guidance (GO:0031290)2.65344438
108adult walking behavior (GO:0007628)2.64980328
109regulation of centriole replication (GO:0046599)2.64633272
110pyrimidine nucleobase catabolic process (GO:0006208)2.64093619
111regulation of synaptic transmission (GO:0050804)2.63297113
112dendritic spine organization (GO:0097061)2.61753067
113regulation of dendritic spine development (GO:0060998)2.61083386
114positive regulation of synapse maturation (GO:0090129)2.60450124
115response to auditory stimulus (GO:0010996)2.60119559
116axon extension (GO:0048675)2.58487377
117acrosome reaction (GO:0007340)2.50968293
118positive regulation of dendritic spine morphogenesis (GO:0061003)2.44971392
119negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43971570
120cell communication by electrical coupling (GO:0010644)2.41293987
121artery development (GO:0060840)2.37216069
122positive regulation of synapse assembly (GO:0051965)2.35022124
123retina layer formation (GO:0010842)2.33359137
124microtubule polymerization or depolymerization (GO:0031109)2.31861667
125renal tubule morphogenesis (GO:0061333)2.31826959
126regulation of axon guidance (GO:1902667)2.30843494
127embryonic retina morphogenesis in camera-type eye (GO:0060059)2.29988497
128negative regulation of hormone biosynthetic process (GO:0032353)2.29798201
129paraxial mesoderm development (GO:0048339)2.29487996
130negative regulation of axon guidance (GO:1902668)2.29222521
131mechanosensory behavior (GO:0007638)2.29057058
132central nervous system projection neuron axonogenesis (GO:0021952)2.28264479
133regulation of axon extension involved in axon guidance (GO:0048841)2.26895131
134cochlea development (GO:0090102)2.25994047
135appendage development (GO:0048736)2.24178008
136limb development (GO:0060173)2.24178008
137negative regulation of axon extension involved in axon guidance (GO:0048843)2.22281700
138limb bud formation (GO:0060174)2.20559330
139neuron projection extension (GO:1990138)2.20087920
140calcium ion-dependent exocytosis (GO:0017156)2.18997094
141negative chemotaxis (GO:0050919)2.18718580
142establishment of nucleus localization (GO:0040023)2.18664963
143short-term memory (GO:0007614)2.16360410
144acrosome assembly (GO:0001675)2.16349391
145inner ear receptor cell development (GO:0060119)2.16347812
146single strand break repair (GO:0000012)2.16137149
147C4-dicarboxylate transport (GO:0015740)2.15550643
148regulation of synapse assembly (GO:0051963)2.15244513
149nucleobase catabolic process (GO:0046113)2.15043938
150spermatid development (GO:0007286)2.13995351
151otic vesicle formation (GO:0030916)2.13430404
152microtubule severing (GO:0051013)2.13106845
153cerebral cortex cell migration (GO:0021795)2.09405398
154spermatid nucleus differentiation (GO:0007289)2.08641182
155regulation of cilium movement (GO:0003352)2.07455663
156cell communication involved in cardiac conduction (GO:0086065)2.06240450
157spinal cord development (GO:0021510)2.05748965
158microtubule nucleation (GO:0007020)2.05458990
159neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.05165304
160centriole replication (GO:0007099)2.04243750
161regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.04224419
162regulation of neuron migration (GO:2001222)2.04155538
163kidney morphogenesis (GO:0060993)2.03050130

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.33554250
2GBX2_23144817_ChIP-Seq_PC3_Human3.80130732
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85397983
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79522321
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73325497
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.47046883
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41674934
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41674934
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37867468
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34270343
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.33218299
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30979817
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29433241
14REST_21632747_ChIP-Seq_MESCs_Mouse2.29062019
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28628202
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27037562
17DROSHA_22980978_ChIP-Seq_HELA_Human2.22310743
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.17572479
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.14947639
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10011334
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07083982
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.04465040
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99249480
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.98499767
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97405711
26TAF15_26573619_Chip-Seq_HEK293_Human1.96532535
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81281576
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.79313107
29AR_21572438_ChIP-Seq_LNCaP_Human1.75347834
30SMAD4_21799915_ChIP-Seq_A2780_Human1.73820367
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73527496
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72437674
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71963254
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67343258
35* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63577486
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63072472
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61949670
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56972945
39P300_19829295_ChIP-Seq_ESCs_Human1.55178079
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50012665
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.47718865
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.46766439
43EWS_26573619_Chip-Seq_HEK293_Human1.45969055
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45694385
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45049261
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44810573
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41329999
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40658528
49STAT3_23295773_ChIP-Seq_U87_Human1.40626289
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40305446
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36119426
52* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35562491
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34749647
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32358924
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.32281541
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31651775
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30711927
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.30301363
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.29258861
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29199551
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28806458
62CBP_20019798_ChIP-Seq_JUKART_Human1.28581898
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28581898
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27117469
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26514596
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26258966
67TCF4_23295773_ChIP-Seq_U87_Human1.23335777
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22220467
69STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22002540
70AR_25329375_ChIP-Seq_VCAP_Human1.21894244
71SOX9_26525672_Chip-Seq_HEART_Mouse1.21050524
72IGF1R_20145208_ChIP-Seq_DFB_Human1.20517150
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19796038
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19633400
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.19347405
76TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18497214
77TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17067063
78* AR_19668381_ChIP-Seq_PC3_Human1.16640616
79* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15453210
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.15232733
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15131994
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14809707
83AHR_22903824_ChIP-Seq_MCF-7_Human1.14058161
84JUN_21703547_ChIP-Seq_K562_Human1.13464299
85* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12373040
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12352701
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.11592823
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10999672
89* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10445981
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10432564
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10000043
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.09978367
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.09689546
94VDR_22108803_ChIP-Seq_LS180_Human1.09249353
95ZNF274_21170338_ChIP-Seq_K562_Hela1.08521618
96* FUS_26573619_Chip-Seq_HEK293_Human1.08445778
97RNF2_27304074_Chip-Seq_NSC_Mouse1.08089055
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.07257663
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06961961
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06922668
101ER_23166858_ChIP-Seq_MCF-7_Human1.06913470
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06837153
103CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06476944
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05787992
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05097881
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04530737
107* RUNX2_22187159_ChIP-Seq_PCA_Human1.03827748
108KDM2B_26808549_Chip-Seq_REH_Human1.02962631
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.02919152
110TP53_16413492_ChIP-PET_HCT116_Human1.00907549
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00531150
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.00179469
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98079360
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98018117
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97970619
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.97922851
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97811609
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.97267788
119BCAT_22108803_ChIP-Seq_LS180_Human0.96981783
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.96519904
121TP53_18474530_ChIP-ChIP_U2OS_Human0.96119535
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94685238
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94685238
124EP300_21415370_ChIP-Seq_HL-1_Mouse0.94370576
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93469616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.37317430
2MP0003880_abnormal_central_pattern4.29965984
3MP0004270_analgesia3.73206037
4MP0003635_abnormal_synaptic_transmissio3.67010758
5MP0009745_abnormal_behavioral_response3.13078360
6MP0002063_abnormal_learning/memory/cond2.95553362
7MP0002064_seizures2.87288585
8MP0009046_muscle_twitch2.73891707
9MP0001968_abnormal_touch/_nociception2.63635484
10MP0002572_abnormal_emotion/affect_behav2.59771855
11MP0002822_catalepsy2.59339198
12MP0002272_abnormal_nervous_system2.56803745
13MP0001486_abnormal_startle_reflex2.53905972
14MP0002734_abnormal_mechanical_nocicepti2.51609405
15MP0005423_abnormal_somatic_nervous2.38720296
16MP0009780_abnormal_chondrocyte_physiolo2.29960017
17MP0005551_abnormal_eye_electrophysiolog2.12460576
18MP0002735_abnormal_chemical_nociception2.08483101
19MP0002736_abnormal_nociception_after2.07024167
20MP0001440_abnormal_grooming_behavior2.00277169
21MP0001501_abnormal_sleep_pattern1.97618245
22MP0000778_abnormal_nervous_system1.86864500
23MP0002067_abnormal_sensory_capabilities1.86284433
24MP0002733_abnormal_thermal_nociception1.80893583
25MP0003121_genomic_imprinting1.80491222
26MP0005646_abnormal_pituitary_gland1.78957101
27MP0003890_abnormal_embryonic-extraembry1.77217427
28MP0001970_abnormal_pain_threshold1.75834914
29MP0001984_abnormal_olfaction1.75288073
30MP0004885_abnormal_endolymph1.71993800
31MP0002909_abnormal_adrenal_gland1.69719467
32MP0003787_abnormal_imprinting1.66293811
33MP0002557_abnormal_social/conspecific_i1.64974292
34MP0004924_abnormal_behavior1.62601901
35MP0005386_behavior/neurological_phenoty1.62601901
36MP0002184_abnormal_innervation1.62079497
37MP0008569_lethality_at_weaning1.58431398
38MP0004043_abnormal_pH_regulation1.55645932
39MP0003329_amyloid_beta_deposits1.53345757
40MP0002882_abnormal_neuron_morphology1.50957170
41MP0006072_abnormal_retinal_apoptosis1.46612658
42MP0001502_abnormal_circadian_rhythm1.46281783
43MP0002102_abnormal_ear_morphology1.45744089
44MP0004811_abnormal_neuron_physiology1.45416785
45MP0001188_hyperpigmentation1.44918970
46MP0000955_abnormal_spinal_cord1.43820266
47MP0003879_abnormal_hair_cell1.43635477
48MP0003937_abnormal_limbs/digits/tail_de1.43537884
49MP0001905_abnormal_dopamine_level1.42256501
50MP0008877_abnormal_DNA_methylation1.40411549
51MP0002938_white_spotting1.39520215
52MP0001529_abnormal_vocalization1.37173317
53MP0006276_abnormal_autonomic_nervous1.36823398
54MP0005410_abnormal_fertilization1.36190500
55MP0002229_neurodegeneration1.33923234
56MP0002066_abnormal_motor_capabilities/c1.33312701
57MP0005253_abnormal_eye_physiology1.28321832
58MP0004858_abnormal_nervous_system1.28250147
59MP0000534_abnormal_ureter_morphology1.27252957
60MP0005623_abnormal_meninges_morphology1.25294279
61MP0001293_anophthalmia1.24937298
62MP0000920_abnormal_myelination1.23580007
63MP0003136_yellow_coat_color1.23432539
64MP0005645_abnormal_hypothalamus_physiol1.22824508
65MP0003633_abnormal_nervous_system1.22108487
66MP0003941_abnormal_skin_development1.21463785
67MP0004742_abnormal_vestibular_system1.21049450
68MP0003119_abnormal_digestive_system1.17700631
69MP0002697_abnormal_eye_size1.15881917
70MP0002233_abnormal_nose_morphology1.15777742
71MP0003283_abnormal_digestive_organ1.13455465
72MP0001177_atelectasis1.12714573
73MP0000049_abnormal_middle_ear1.11877830
74MP0000462_abnormal_digestive_system1.11460569
75MP0000013_abnormal_adipose_tissue1.10824900
76MP0003942_abnormal_urinary_system1.10241877
77MP0005248_abnormal_Harderian_gland1.10140054
78MP0001286_abnormal_eye_development1.09991318
79MP0003122_maternal_imprinting1.09985044
80MP0004133_heterotaxia1.08597365
81MP0010386_abnormal_urinary_bladder1.08269018
82MP0003861_abnormal_nervous_system1.08110752
83MP0005377_hearing/vestibular/ear_phenot1.07268039
84MP0003878_abnormal_ear_physiology1.07268039
85MP0001963_abnormal_hearing_physiology1.06399619
86MP0005409_darkened_coat_color1.06121025
87MP0003631_nervous_system_phenotype1.05519469
88MP0003385_abnormal_body_wall1.05121589
89MP0001485_abnormal_pinna_reflex1.04231104
90MP0005503_abnormal_tendon_morphology1.04214358
91MP0009250_abnormal_appendicular_skeleto1.04196489
92MP0004142_abnormal_muscle_tone1.04139264
93MP0002152_abnormal_brain_morphology1.03963223
94MP0003123_paternal_imprinting1.03218014
95MP0003634_abnormal_glial_cell1.03200850
96MP0009384_cardiac_valve_regurgitation1.00960813
97MP0002752_abnormal_somatic_nervous1.00215176
98MP0004272_abnormal_basement_membrane0.99544453
99MP0003755_abnormal_palate_morphology0.99115710
100MP0003698_abnormal_male_reproductive0.99042258
101MP0002090_abnormal_vision0.97367691
102MP0000631_abnormal_neuroendocrine_gland0.97231833
103MP0004145_abnormal_muscle_electrophysio0.96739517
104MP0002751_abnormal_autonomic_nervous0.96669331
105MP0003567_abnormal_fetal_cardiomyocyte0.96246555
106MP0001299_abnormal_eye_distance/0.93991115
107MP0002638_abnormal_pupillary_reflex0.93612561
108MP0000566_synostosis0.92553425
109MP0002837_dystrophic_cardiac_calcinosis0.90740840
110MP0004085_abnormal_heartbeat0.90286946
111MP0003935_abnormal_craniofacial_develop0.90150150
112MP0005394_taste/olfaction_phenotype0.90066959
113MP0005499_abnormal_olfactory_system0.90066959
114MP0010030_abnormal_orbit_morphology0.89819400
115MP0000428_abnormal_craniofacial_morphol0.88069495
116MP0002160_abnormal_reproductive_system0.86969241
117MP0003690_abnormal_glial_cell0.85927180
118MP0002069_abnormal_eating/drinking_beha0.84998399
119MP0005391_vision/eye_phenotype0.84178433
120MP0005535_abnormal_body_temperature0.82930220
121MP0008438_abnormal_cutaneous_collagen0.82686268
122MP0008789_abnormal_olfactory_epithelium0.82366682
123MP0005195_abnormal_posterior_eye0.81090279
124MP0003632_abnormal_nervous_system0.80020919
125MP0003183_abnormal_peptide_metabolism0.77930327
126MP0000751_myopathy0.76605603
127MP0002876_abnormal_thyroid_physiology0.75946282
128MP0008872_abnormal_physiological_respon0.73352319
129MP0000026_abnormal_inner_ear0.70768198
130MP0006292_abnormal_olfactory_placode0.69884480
131MP0002234_abnormal_pharynx_morphology0.67942798
132MP0000678_abnormal_parathyroid_gland0.67143594
133MP0008874_decreased_physiological_sensi0.66531453
134MP0008961_abnormal_basal_metabolism0.65635016
135MP0004215_abnormal_myocardial_fiber0.64882662
136MP0001765_abnormal_ion_homeostasis0.63167695
137MP0005171_absent_coat_pigmentation0.62464117
138MP0003137_abnormal_impulse_conducting0.61200632
139MP0000569_abnormal_digit_pigmentation0.60140164
140MP0005187_abnormal_penis_morphology0.59555273
141MP0004484_altered_response_of0.58330671
142MP0004233_abnormal_muscle_weight0.58313033

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.79223404
2Myokymia (HP:0002411)5.59106965
3Focal seizures (HP:0007359)4.66399765
4Epileptic encephalopathy (HP:0200134)4.52353361
5Atonic seizures (HP:0010819)4.24465334
6Febrile seizures (HP:0002373)4.04091942
7Visual hallucinations (HP:0002367)3.74340516
8Hyperventilation (HP:0002883)3.62936071
9Broad-based gait (HP:0002136)3.58891081
10Progressive cerebellar ataxia (HP:0002073)3.47371041
11Absence seizures (HP:0002121)3.40558910
12Action tremor (HP:0002345)3.31069896
13Generalized tonic-clonic seizures (HP:0002069)3.21223514
14Dialeptic seizures (HP:0011146)3.12374450
15Gaze-evoked nystagmus (HP:0000640)3.05434036
16Ankle clonus (HP:0011448)3.00069033
17Abnormality of the corticospinal tract (HP:0002492)2.98326258
18Supranuclear gaze palsy (HP:0000605)2.98081215
19Degeneration of the lateral corticospinal tracts (HP:0002314)2.97922750
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.97922750
21Dysmetria (HP:0001310)2.92970850
22Impaired vibration sensation in the lower limbs (HP:0002166)2.87233783
23Dysdiadochokinesis (HP:0002075)2.85919521
24Poor eye contact (HP:0000817)2.85411130
25Congenital stationary night blindness (HP:0007642)2.77068196
26Central scotoma (HP:0000603)2.74510738
27Excessive salivation (HP:0003781)2.72959984
28Drooling (HP:0002307)2.72959984
29Abnormality of macular pigmentation (HP:0008002)2.72174255
30Anxiety (HP:0000739)2.70750279
31Truncal ataxia (HP:0002078)2.67735148
32Neurofibrillary tangles (HP:0002185)2.66198714
33Chronic hepatic failure (HP:0100626)2.63244826
34Insidious onset (HP:0003587)2.62918675
35Termporal pattern (HP:0011008)2.62918675
36Spastic gait (HP:0002064)2.62685404
37Depression (HP:0000716)2.59220470
38Tubulointerstitial nephritis (HP:0001970)2.59033152
39Scanning speech (HP:0002168)2.57249313
40Abnormality of the labia minora (HP:0012880)2.52600665
41Abnormal social behavior (HP:0012433)2.51714057
42Impaired social interactions (HP:0000735)2.51714057
43Increased circulating renin level (HP:0000848)2.49176616
44Epileptiform EEG discharges (HP:0011182)2.47970512
45Pheochromocytoma (HP:0002666)2.47919065
46Urinary bladder sphincter dysfunction (HP:0002839)2.47326772
47Amblyopia (HP:0000646)2.46389025
48Absent speech (HP:0001344)2.43033559
49Bony spicule pigmentary retinopathy (HP:0007737)2.40740697
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.39626199
51Hepatoblastoma (HP:0002884)2.38265989
52Cerebral inclusion bodies (HP:0100314)2.37362405
53Dyschromatopsia (HP:0007641)2.36752668
54Fetal akinesia sequence (HP:0001989)2.36096684
55EEG with generalized epileptiform discharges (HP:0011198)2.34243712
56Optic nerve hypoplasia (HP:0000609)2.32891434
57Retinal dysplasia (HP:0007973)2.27240606
58Septo-optic dysplasia (HP:0100842)2.27132938
59Intention tremor (HP:0002080)2.26293175
60Urinary urgency (HP:0000012)2.24740862
61Abnormal eating behavior (HP:0100738)2.23352516
62Hypsarrhythmia (HP:0002521)2.20797589
63Protruding tongue (HP:0010808)2.20088311
64Nephronophthisis (HP:0000090)2.18398680
65Genetic anticipation (HP:0003743)2.17173578
66Agitation (HP:0000713)2.17117800
67Gait imbalance (HP:0002141)2.16178585
68Postural instability (HP:0002172)2.16166250
69Megalencephaly (HP:0001355)2.16146711
70Lower limb muscle weakness (HP:0007340)2.14806049
71Impaired smooth pursuit (HP:0007772)2.13931870
72Anophthalmia (HP:0000528)2.13357525
73Preaxial foot polydactyly (HP:0001841)2.12247403
74Scotoma (HP:0000575)2.10658652
75Neuroendocrine neoplasm (HP:0100634)2.08960219
76Stereotypic behavior (HP:0000733)2.08954408
77Blue irides (HP:0000635)2.08748955
78Intestinal atresia (HP:0011100)2.07177766
79Aplasia involving bones of the upper limbs (HP:0009823)2.06391764
80Aplasia of the phalanges of the hand (HP:0009802)2.06391764
81Aplasia involving bones of the extremities (HP:0009825)2.06391764
82Vaginal atresia (HP:0000148)2.06335116
83Hemiparesis (HP:0001269)2.05390199
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02687986
85Hypoglycemic seizures (HP:0002173)2.02070600
86Torticollis (HP:0000473)2.00128924
87Thickened helices (HP:0000391)1.98225818
88Mutism (HP:0002300)1.94913778
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.94887066
90Absent/shortened dynein arms (HP:0200106)1.94887066
91Choroideremia (HP:0001139)1.92693272
92Abnormality of salivation (HP:0100755)1.92280091
93Impaired vibratory sensation (HP:0002495)1.88871697
94Abnormality of ocular smooth pursuit (HP:0000617)1.87777821
95Metabolic alkalosis (HP:0200114)1.86930975
96Hyperinsulinemic hypoglycemia (HP:0000825)1.86242567
97Midline defect of the nose (HP:0004122)1.85860274
98Papilledema (HP:0001085)1.85213783
99Generalized myoclonic seizures (HP:0002123)1.85153301
100Diplopia (HP:0000651)1.83061049
101Abnormality of binocular vision (HP:0011514)1.83061049
102Pancreatic fibrosis (HP:0100732)1.82709338
103Cutaneous finger syndactyly (HP:0010554)1.82467029
104Congenital primary aphakia (HP:0007707)1.81057375
105Akinesia (HP:0002304)1.80131304
106Widely spaced teeth (HP:0000687)1.80079267
107Aqueductal stenosis (HP:0002410)1.79513970
108Prolonged QT interval (HP:0001657)1.78465682
109Medial flaring of the eyebrow (HP:0010747)1.77562492
110Focal dystonia (HP:0004373)1.76536058
111Abnormal rod and cone electroretinograms (HP:0008323)1.76509344
112Inability to walk (HP:0002540)1.75776282
113Coronal craniosynostosis (HP:0004440)1.75649644
114Abnormality of the renal medulla (HP:0100957)1.73980506
115Bifid tongue (HP:0010297)1.72852513
116Limb dystonia (HP:0002451)1.72493472
117Overgrowth (HP:0001548)1.71305601
118Bradykinesia (HP:0002067)1.71142974
119Gastrointestinal atresia (HP:0002589)1.70953816
120Abnormality of the ischium (HP:0003174)1.70792282
121Cutaneous syndactyly (HP:0012725)1.70041630
122Progressive inability to walk (HP:0002505)1.69889751
123Atrial fibrillation (HP:0005110)1.68784439
124Abnormal EKG (HP:0003115)1.68579208
125Poor coordination (HP:0002370)1.68488390
126Broad metatarsal (HP:0001783)1.68129822
127Nephrogenic diabetes insipidus (HP:0009806)1.68100199
128Growth hormone deficiency (HP:0000824)1.67101949
129Intellectual disability, moderate (HP:0002342)1.66546538
130Gait ataxia (HP:0002066)1.66249838
131Abnormality of calcium-phosphate metabolism (HP:0100530)1.66203654
132Omphalocele (HP:0001539)1.66189128
133Type II lissencephaly (HP:0007260)1.65532229
134Genital tract atresia (HP:0001827)1.65519879
135Maternal diabetes (HP:0009800)1.64196030
136True hermaphroditism (HP:0010459)1.63098149
137Bilateral microphthalmos (HP:0007633)1.62919619
138Abnormal pancreas size (HP:0012094)1.62483923
139Menstrual irregularities (HP:0000858)1.62127698
140Supernumerary spleens (HP:0009799)1.59793386
141Renal hypoplasia (HP:0000089)1.58110400
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.57982902
143Sleep apnea (HP:0010535)1.57296058
144Abnormality of dentin (HP:0010299)1.57281449
145Absent eyebrow (HP:0002223)1.56263355
146Postaxial hand polydactyly (HP:0001162)1.54978503
147Esophageal atresia (HP:0002032)1.54964336
148Abnormality of the middle phalanges of the toes (HP:0010183)1.54841766
149Polyphagia (HP:0002591)1.54146610
150Abnormal ciliary motility (HP:0012262)1.53000038
151Failure to thrive in infancy (HP:0001531)1.52399667
152Short hallux (HP:0010109)1.51772480
153Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.51552518
154Short tibia (HP:0005736)1.51523383
155Double outlet right ventricle (HP:0001719)1.50579624
156Congenital malformation of the right heart (HP:0011723)1.50579624
157Primary atrial arrhythmia (HP:0001692)1.50079697
158Tubulointerstitial abnormality (HP:0001969)1.50037590
159Myelomeningocele (HP:0002475)1.49825251
160Aplasia/Hypoplasia of the sternum (HP:0006714)1.48514295
161Partial duplication of thumb phalanx (HP:0009944)1.47915389
162Duplication of thumb phalanx (HP:0009942)1.47761468
163Aplasia/Hypoplasia of the hallux (HP:0008362)1.46412751
164Abnormal respiratory motile cilium physiology (HP:0012261)1.45923372
165Labial hypoplasia (HP:0000066)1.45410253
166Neonatal short-limb short stature (HP:0008921)1.42942941
167Limited hip movement (HP:0008800)1.42847850
168Occipital encephalocele (HP:0002085)1.42572895
169Hypoplastic ischia (HP:0003175)1.42519012
170Mixed hearing impairment (HP:0000410)1.41869960
171Oligodactyly (hands) (HP:0001180)1.41100554
172Colon cancer (HP:0003003)1.41085747
173Abnormality of the pubic bones (HP:0003172)1.40573442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.16375390
2NTRK34.08163378
3PLK42.89979420
4MARK12.84143318
5MAP3K42.67364966
6CASK2.61918982
7MAP2K72.45036684
8MAP3K92.39523499
9PRKD32.23676490
10TNIK2.18949878
11MINK12.08650296
12OXSR12.07334432
13DAPK21.91247799
14NTRK11.85908100
15PAK61.82555020
16STK391.81325881
17BRSK21.80774234
18FRK1.63929478
19TRIM281.62663504
20STK38L1.62416526
21PRPF4B1.60561811
22NTRK21.59372434
23PNCK1.58997923
24MAP3K21.57115727
25MAPK131.54045711
26SGK4941.53174329
27SGK2231.53174329
28MKNK21.51885471
29WNK41.49950528
30CDK51.46555407
31PLK21.44164612
32KSR21.42052206
33CAMKK11.41004200
34RIPK41.40552687
35MAP2K41.39889668
36BMPR1B1.38527436
37KSR11.37263747
38CAMKK21.34415733
39BRD41.26912125
40PINK11.25845070
41GRK51.23643352
42WEE11.22807853
43BRSK11.21858690
44SGK21.21369904
45DYRK21.18886551
46UHMK11.17825044
47EPHB21.17819790
48CAMK2B1.17367194
49WNK11.17253611
50CDK191.17133465
51LATS21.16660521
52LATS11.16338035
53SIK21.11263026
54CAMK2A1.11166844
55BMPR21.10676719
56PAK31.08417099
57INSRR1.06533546
58PRKCG1.06336590
59PLK31.05073448
60AKT31.04845915
61NEK61.04130678
62STK381.00888837
63PHKG10.98092263
64PHKG20.98092263
65WNK30.96892117
66PRKCH0.95180594
67DMPK0.94839148
68FES0.93735752
69TYRO30.92272499
70DAPK10.91026986
71CAMK2D0.87476390
72MKNK10.86881600
73SGK30.86838584
74TAF10.85608211
75BCR0.85455190
76STK110.84018359
77ZAK0.83897313
78PRKCE0.82136202
79SGK10.81190576
80DYRK1A0.79552972
81FGFR10.79433700
82MARK20.79254024
83CSNK1G20.77579425
84MAP3K120.77054456
85CSNK1G10.76095786
86CAMK10.75290331
87DDR20.74692514
88PTK2B0.73750800
89FGFR20.71955872
90ARAF0.71778724
91PKN10.70736900
92DYRK30.70237805
93ERBB30.69405258
94CAMK1G0.68865098
95CDK30.68074940
96CDK180.67445730
97ERBB40.67085025
98MAPKAPK50.65790094
99CDK140.65457635
100PDGFRA0.64907943
101RET0.64690392
102CDK150.64225252
103MAP3K130.64160322
104PDPK10.63934288
105CAMK2G0.61160922
106CDC70.59384556
107NUAK10.58785831
108OBSCN0.55620828
109SIK30.55403638
110TIE10.54017480
111EPHA30.53918542
112FLT30.53787225
113FER0.53431188
114MAP3K10.52517525
115CSNK1E0.52475385
116CDK11A0.52273729
117PRKCZ0.52267978
118NEK90.51332490
119PLK10.51217895
120MAPK150.49657484
121GRK10.49017803
122PDK10.48758746
123HIPK20.47815798
124CSNK1G30.47313868
125RPS6KA40.46744686
126RPS6KA30.46237250
127ROCK20.45632009
128VRK10.45475471
129STK30.45054328
130PBK0.43281632
131MAPK100.43164150
132CDC42BPA0.43122476
133FYN0.42643133
134DYRK1B0.42334199
135MET0.42036785
136FGR0.41196470
137PRKACA0.40475427
138ROCK10.40250922
139ADRBK10.39967697
140RAF10.38514836
141CAMK40.38458491
142PRKD20.37900486
143CSNK1A10.37816276
144CSNK1A1L0.37738704
145PRKG10.36392404

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.31676307
2Phototransduction_Homo sapiens_hsa047443.05790583
3Synaptic vesicle cycle_Homo sapiens_hsa047212.87953744
4Olfactory transduction_Homo sapiens_hsa047402.66840289
5Circadian entrainment_Homo sapiens_hsa047132.62255578
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56382806
7GABAergic synapse_Homo sapiens_hsa047272.56124454
8Long-term potentiation_Homo sapiens_hsa047202.50707413
9Morphine addiction_Homo sapiens_hsa050322.46108306
10* Glutamatergic synapse_Homo sapiens_hsa047242.45905539
11Amphetamine addiction_Homo sapiens_hsa050312.43354715
12Insulin secretion_Homo sapiens_hsa049112.14312192
13Dopaminergic synapse_Homo sapiens_hsa047282.13337917
14Salivary secretion_Homo sapiens_hsa049701.96909530
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96888819
16Cholinergic synapse_Homo sapiens_hsa047251.89201534
17Hedgehog signaling pathway_Homo sapiens_hsa043401.85549910
18Taste transduction_Homo sapiens_hsa047421.84964625
19* Serotonergic synapse_Homo sapiens_hsa047261.82132989
20Cocaine addiction_Homo sapiens_hsa050301.76087758
21Long-term depression_Homo sapiens_hsa047301.75399831
22Gastric acid secretion_Homo sapiens_hsa049711.73588296
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68611672
24Renin secretion_Homo sapiens_hsa049241.64501894
25Collecting duct acid secretion_Homo sapiens_hsa049661.57942427
26Oxytocin signaling pathway_Homo sapiens_hsa049211.50445899
27Basal cell carcinoma_Homo sapiens_hsa052171.50124779
28Protein export_Homo sapiens_hsa030601.49888777
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49210954
30Calcium signaling pathway_Homo sapiens_hsa040201.46125872
31Hippo signaling pathway_Homo sapiens_hsa043901.42070618
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37039442
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33939920
34cAMP signaling pathway_Homo sapiens_hsa040241.28941572
35Axon guidance_Homo sapiens_hsa043601.24090445
36Propanoate metabolism_Homo sapiens_hsa006401.23537833
37Fatty acid biosynthesis_Homo sapiens_hsa000611.23164668
38GnRH signaling pathway_Homo sapiens_hsa049121.22113909
39Gap junction_Homo sapiens_hsa045401.21945899
40Steroid biosynthesis_Homo sapiens_hsa001001.21884946
41ECM-receptor interaction_Homo sapiens_hsa045121.18883815
42Type II diabetes mellitus_Homo sapiens_hsa049301.16240423
43Vibrio cholerae infection_Homo sapiens_hsa051101.15418359
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13314819
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11381680
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10902112
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08716270
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08158024
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01180236
50Tight junction_Homo sapiens_hsa045301.00111782
51Estrogen signaling pathway_Homo sapiens_hsa049150.99587078
52Vitamin B6 metabolism_Homo sapiens_hsa007500.98740116
53Glioma_Homo sapiens_hsa052140.98505674
54ErbB signaling pathway_Homo sapiens_hsa040120.97692624
55Adherens junction_Homo sapiens_hsa045200.97373739
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.96889804
57TGF-beta signaling pathway_Homo sapiens_hsa043500.96585780
58Melanogenesis_Homo sapiens_hsa049160.93905949
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93903078
60* Pancreatic secretion_Homo sapiens_hsa049720.89268309
61Cardiac muscle contraction_Homo sapiens_hsa042600.87948007
62Dorso-ventral axis formation_Homo sapiens_hsa043200.87364910
63Thyroid hormone synthesis_Homo sapiens_hsa049180.85816321
64Huntingtons disease_Homo sapiens_hsa050160.84429762
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83747991
66Basal transcription factors_Homo sapiens_hsa030220.82871185
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81915772
68Circadian rhythm_Homo sapiens_hsa047100.80737016
69Dilated cardiomyopathy_Homo sapiens_hsa054140.79344005
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.76621914
71Protein digestion and absorption_Homo sapiens_hsa049740.74501501
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73005765
73Choline metabolism in cancer_Homo sapiens_hsa052310.72952786
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71239892
75Non-homologous end-joining_Homo sapiens_hsa034500.70727239
76Fanconi anemia pathway_Homo sapiens_hsa034600.69400775
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68118040
78Parkinsons disease_Homo sapiens_hsa050120.67488115
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67021652
80Fatty acid metabolism_Homo sapiens_hsa012120.66634871
81Ras signaling pathway_Homo sapiens_hsa040140.65746289
82MAPK signaling pathway_Homo sapiens_hsa040100.65718287
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64570158
84Ovarian steroidogenesis_Homo sapiens_hsa049130.64296659
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63870566
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63812357
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63080925
88Nitrogen metabolism_Homo sapiens_hsa009100.62986575
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61939503
90Glucagon signaling pathway_Homo sapiens_hsa049220.60249361
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60218965
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59243158
93Regulation of autophagy_Homo sapiens_hsa041400.58399735
94Oocyte meiosis_Homo sapiens_hsa041140.56119846
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55869081
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55268752
97Melanoma_Homo sapiens_hsa052180.55121876
98RNA transport_Homo sapiens_hsa030130.54991793
99Focal adhesion_Homo sapiens_hsa045100.54311293
100Alcoholism_Homo sapiens_hsa050340.52159496
101Alzheimers disease_Homo sapiens_hsa050100.50156521
102Inositol phosphate metabolism_Homo sapiens_hsa005620.49964418
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.49788637
104Rap1 signaling pathway_Homo sapiens_hsa040150.49709940
105Type I diabetes mellitus_Homo sapiens_hsa049400.48223491
106Renal cell carcinoma_Homo sapiens_hsa052110.47792033
107RNA degradation_Homo sapiens_hsa030180.47688530
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45767507
109mRNA surveillance pathway_Homo sapiens_hsa030150.45636877
110Wnt signaling pathway_Homo sapiens_hsa043100.43926778
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42536301
112Cell cycle_Homo sapiens_hsa041100.41908457
113Selenocompound metabolism_Homo sapiens_hsa004500.41763881
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41061703
115Endocytosis_Homo sapiens_hsa041440.40367970
116Ether lipid metabolism_Homo sapiens_hsa005650.39541395
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38408272
118Folate biosynthesis_Homo sapiens_hsa007900.38134169
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37920650
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.37702136
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37037309
122Sphingolipid metabolism_Homo sapiens_hsa006000.36669625
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36149910
124VEGF signaling pathway_Homo sapiens_hsa043700.36095013
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35987233
126Bile secretion_Homo sapiens_hsa049760.34713195
127Rheumatoid arthritis_Homo sapiens_hsa053230.33888783
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32923792
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.31107704
130Oxidative phosphorylation_Homo sapiens_hsa001900.29872344
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29207094
132mTOR signaling pathway_Homo sapiens_hsa041500.29151275
133Mineral absorption_Homo sapiens_hsa049780.29108207
134Butanoate metabolism_Homo sapiens_hsa006500.29099803
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27852445
136Chemokine signaling pathway_Homo sapiens_hsa040620.27366964

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