TRPC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr7.90691400
2metanephric mesenchyme development (GO:0072075)7.25069498
3histone H2A monoubiquitination (GO:0035518)7.11294268
4metanephric nephron tubule development (GO:0072234)7.00425803
5metanephric tubule development (GO:0072170)7.00425803
6regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 6.91035917
7artery development (GO:0060840)6.71849582
8activin receptor signaling pathway (GO:0032924)6.40831489
9kidney mesenchyme development (GO:0072074)6.32726096
10neutrophil activation involved in immune response (GO:0002283)6.28148144
11metanephric nephron epithelium development (GO:0072243)6.27798316
12negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)6.21872197
13pyrimidine dimer repair (GO:0006290)6.14710740
14histone H2A ubiquitination (GO:0033522)6.06058681
15positive regulation of tolerance induction (GO:0002645)6.03413682
16thrombin receptor signaling pathway (GO:0070493)5.96019989
17positive regulation of mast cell activation (GO:0033005)5.94650114
18positive regulation of mast cell degranulation (GO:0043306)5.89440378
19positive regulation of mast cell activation involved in immune response (GO:0033008)5.89440378
20metanephric epithelium development (GO:0072207)5.75870875
21cellular response to fluid shear stress (GO:0071498)5.32346621
22pre-miRNA processing (GO:0031054)5.22108631
23lipoxygenase pathway (GO:0019372)5.18537453
24regulation of tolerance induction (GO:0002643)5.17582595
25blood vessel maturation (GO:0001955)5.10060883
26neuromuscular process controlling posture (GO:0050884)5.05214281
27ovulation from ovarian follicle (GO:0001542)4.81164947
28response to water (GO:0009415)4.81161348
29regulation of mast cell activation involved in immune response (GO:0033006)4.80281968
30definitive hemopoiesis (GO:0060216)4.75693475
31osteoclast differentiation (GO:0030316)4.74288268
32regulation of mast cell degranulation (GO:0043304)4.72915003
33megakaryocyte development (GO:0035855)4.70926736
34protein neddylation (GO:0045116)4.64405040
35smooth muscle tissue development (GO:0048745)4.52952627
36positive regulation of male gonad development (GO:2000020)4.49190403
37purinergic nucleotide receptor signaling pathway (GO:0035590)4.45388202
38adenosine receptor signaling pathway (GO:0001973)4.44108000
39regulation of female receptivity (GO:0045924)4.40297618
40polarized epithelial cell differentiation (GO:0030859)4.39564848
41negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.33033560
42negative regulation of translation, ncRNA-mediated (GO:0040033)4.33033560
43regulation of translation, ncRNA-mediated (GO:0045974)4.33033560
44regulation of platelet activation (GO:0010543)4.28011752
45positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.27479184
46positive regulation of synaptic transmission, GABAergic (GO:0032230)4.27088607
47establishment of apical/basal cell polarity (GO:0035089)4.24858352
48establishment or maintenance of monopolar cell polarity (GO:0061339)4.23675437
49establishment of monopolar cell polarity (GO:0061162)4.23675437
50nephron tubule development (GO:0072080)4.21194023
51regulation of mast cell activation (GO:0033003)4.17163059
52spinal cord development (GO:0021510)4.11679475
53female mating behavior (GO:0060180)4.11272911
54regulation of platelet aggregation (GO:0090330)4.02988969
55regulation of male gonad development (GO:2000018)4.02057024
56glucosamine-containing compound catabolic process (GO:1901072)4.01204463
57imidazole-containing compound metabolic process (GO:0052803)3.98772550
58negative regulation of thymocyte apoptotic process (GO:0070244)3.93815952
59positive regulation of leukocyte degranulation (GO:0043302)3.92055571
60negative regulation of interleukin-12 production (GO:0032695)3.92007653
61neutrophil activation (GO:0042119)3.90112113
62negative regulation of bone resorption (GO:0045779)3.89485310
63aggressive behavior (GO:0002118)3.88855758
64membrane tubulation (GO:0097320)3.86097277
65renal tubule morphogenesis (GO:0061333)3.83403481
66positive regulation of amino acid transport (GO:0051957)3.82930908
67positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.79639934
68mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.79639934
69regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.77200541
70positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.77200541
71endothelium development (GO:0003158)3.73795600
72regulation of MHC class II biosynthetic process (GO:0045346)3.72786180
73purinergic receptor signaling pathway (GO:0035587)3.71230657
74response to pheromone (GO:0019236)3.71008845
75centrosome duplication (GO:0051298)3.70103109
76angiogenesis involved in wound healing (GO:0060055)3.69022763
77renal tubule development (GO:0061326)3.64454070
78regulation of myeloid leukocyte mediated immunity (GO:0002886)3.63999331
79prepulse inhibition (GO:0060134)3.63700506
80cellular biogenic amine biosynthetic process (GO:0042401)3.60951082
81negative regulation of phagocytosis (GO:0050765)3.58196083
82regulation of integrin activation (GO:0033623)3.57521569
83striatum development (GO:0021756)3.55653832
84negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.55219008
85positive regulation of urine volume (GO:0035810)3.54923811
86positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)3.54297703
87blood coagulation, intrinsic pathway (GO:0007597)3.53101466
88positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.51807334
89granulocyte activation (GO:0036230)3.50538706
90deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.49485832
91negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.49258095
92translesion synthesis (GO:0019985)3.48646516
93positive regulation of B cell differentiation (GO:0045579)3.48426670
94negative regulation of cytokine production involved in immune response (GO:0002719)3.47858226
95maturation of SSU-rRNA (GO:0030490)3.47214332
96regulation of leukocyte degranulation (GO:0043300)3.46995997
97neural tube development (GO:0021915)3.45972532
98negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.45830267
99negative regulation of calcium ion transmembrane transport (GO:1903170)3.45830267
100negative regulation of cation channel activity (GO:2001258)3.43699605
101amine biosynthetic process (GO:0009309)3.43385063
102ear development (GO:0043583)3.43104827
103interleukin-1-mediated signaling pathway (GO:0070498)3.42266037
104negative regulation of cytosolic calcium ion concentration (GO:0051481)3.42260681
105ribosomal small subunit assembly (GO:0000028)3.41543492
106cellular response to osmotic stress (GO:0071470)3.41051324
107immunoglobulin mediated immune response (GO:0016064)3.40894868
108nephron epithelium development (GO:0072009)3.40188056
109regulation of T cell cytokine production (GO:0002724)3.35513516
110histone monoubiquitination (GO:0010390)3.33264067
111respiratory system process (GO:0003016)3.30668722
112inner ear receptor cell development (GO:0060119)3.29959685
113platelet aggregation (GO:0070527)3.29773744
114B cell mediated immunity (GO:0019724)3.27110341
115retinal rod cell development (GO:0046548)3.26334757
116male sex determination (GO:0030238)3.25817530
117monoamine transport (GO:0015844)3.24085058
118leukocyte migration involved in inflammatory response (GO:0002523)3.22825056
119regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21140628
120response to caffeine (GO:0031000)3.20960919
121triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.19764835
122negative regulation of bone remodeling (GO:0046851)3.18365419
123low-density lipoprotein particle remodeling (GO:0034374)3.17294971
124autophagic vacuole fusion (GO:0000046)3.15903221
125positive regulation of systemic arterial blood pressure (GO:0003084)3.11607806
126protein K6-linked ubiquitination (GO:0085020)3.11051209
127G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.06733570
128positive regulation of granulocyte differentiation (GO:0030854)3.05377456
129leukotriene biosynthetic process (GO:0019370)3.05015544
130purine-containing compound salvage (GO:0043101)3.04910586
131positive regulation of neurotransmitter secretion (GO:0001956)3.04718102
132paraxial mesoderm development (GO:0048339)3.03762460
133muscle organ morphogenesis (GO:0048644)3.01853823
134cardiolipin metabolic process (GO:0032048)3.01685637
135icosanoid biosynthetic process (GO:0046456)3.01580199
136fatty acid derivative biosynthetic process (GO:1901570)3.01580199
137negative regulation of erythrocyte differentiation (GO:0045647)3.00366641
138positive regulation of macrophage differentiation (GO:0045651)2.96767314
139negative regulation of T cell apoptotic process (GO:0070233)2.96736601
140cerebellar Purkinje cell layer development (GO:0021680)2.95758059
141regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.95651642
142determination of left/right symmetry (GO:0007368)2.95209274
143regulation of norepinephrine secretion (GO:0014061)2.94711950
144negative regulation of norepinephrine secretion (GO:0010700)2.94129097
145basic amino acid transport (GO:0015802)2.93859598
146organelle membrane fusion (GO:0090174)2.92818659
147leukocyte degranulation (GO:0043299)2.91680766
148regulation of macrophage cytokine production (GO:0010935)2.90302952
149embryonic placenta development (GO:0001892)2.89938914
150grooming behavior (GO:0007625)2.89774138
151RNA destabilization (GO:0050779)2.89663338
152positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87921565
153negative regulation of heart rate (GO:0010459)2.87778527
154establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.86690081
155mature B cell differentiation involved in immune response (GO:0002313)2.86423747
156positive regulation of regulated secretory pathway (GO:1903307)2.83863580
157microglial cell activation (GO:0001774)2.83820693
158myeloid cell activation involved in immune response (GO:0002275)2.83554903
159regulation of penile erection (GO:0060405)2.82383411
160regulation of erythrocyte differentiation (GO:0045646)2.82311970
161regulation of glutamate secretion (GO:0014048)2.80787246
162fusion of sperm to egg plasma membrane (GO:0007342)2.80655762
163negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80126413
164negative regulation of T-helper cell differentiation (GO:0045623)2.80126413
165determination of bilateral symmetry (GO:0009855)2.79948016
166synaptic transmission, dopaminergic (GO:0001963)2.79767707
167pyrimidine nucleobase catabolic process (GO:0006208)2.78399949
168specification of symmetry (GO:0009799)2.77053559
169histone ubiquitination (GO:0016574)2.76643532
170regulation of Golgi to plasma membrane protein transport (GO:0042996)2.76462147
171leukotriene metabolic process (GO:0006691)2.74284363
172sleep (GO:0030431)2.71712695
173regulation of hypersensitivity (GO:0002883)2.70344439
174negative regulation of platelet activation (GO:0010544)2.69838606
175positive regulation of endothelial cell differentiation (GO:0045603)2.66896790
176cellular response to exogenous dsRNA (GO:0071360)2.65691562
177positive regulation of cAMP-mediated signaling (GO:0043950)2.64818489
178activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.63456486
179regulation of regulated secretory pathway (GO:1903305)2.60968545
180defense response to protozoan (GO:0042832)2.59106842
181negative regulation of nitric oxide biosynthetic process (GO:0045019)2.58325837
182negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.58069293
183negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.57800256
184poly(A)+ mRNA export from nucleus (GO:0016973)2.57785298
185regulation of cholesterol efflux (GO:0010874)2.55940945
186cellular biogenic amine catabolic process (GO:0042402)2.55827795
187amine catabolic process (GO:0009310)2.55827795
188mitochondrial calcium ion transport (GO:0006851)2.55164687
189mast cell activation (GO:0045576)2.53965470
190regulation of megakaryocyte differentiation (GO:0045652)2.52248492
191polyamine biosynthetic process (GO:0006596)2.51013985
192platelet degranulation (GO:0002576)2.50041301
193phosphatidylinositol acyl-chain remodeling (GO:0036149)2.49727720
194regulation of activated T cell proliferation (GO:0046006)2.49467247
195platelet activation (GO:0030168)2.48644395
196regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.48395611
197nodal signaling pathway (GO:0038092)14.0064241

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.52551936
2* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.67089750
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.50845881
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.40145405
5EZH2_22144423_ChIP-Seq_EOC_Human3.27150540
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.26284897
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.20888788
8GBX2_23144817_ChIP-Seq_PC3_Human3.18132780
9LMO2_20887958_ChIP-Seq_HPC-7_Mouse3.16716174
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.95178017
11ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.82090249
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.77960088
13ZNF274_21170338_ChIP-Seq_K562_Hela2.74319016
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71687220
15GATA1_19941826_ChIP-Seq_K562_Human2.69820772
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.68587663
17GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.65199426
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64020803
19SCL_19346495_ChIP-Seq_HPC-7_Human2.60251219
20GATA1_22025678_ChIP-Seq_K562_Human2.47461559
21GATA1_26923725_Chip-Seq_HPCs_Mouse2.47171239
22* GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.44906455
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35431263
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.34558878
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.32331089
26JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29649692
27TAF15_26573619_Chip-Seq_HEK293_Human2.29185282
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27461805
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27461805
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27320544
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.23464547
32ERG_21242973_ChIP-ChIP_JURKAT_Human2.22917448
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20453101
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16651830
35SPI1_23127762_ChIP-Seq_K562_Human2.15476882
36DROSHA_22980978_ChIP-Seq_HELA_Human2.13384491
37TRIM28_21343339_ChIP-Seq_HEK293_Human2.12583411
38ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11711797
39EZH2_27304074_Chip-Seq_ESCs_Mouse2.10485690
40EZH2_27294783_Chip-Seq_ESCs_Mouse2.10182544
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07924553
42SPI1_23547873_ChIP-Seq_NB4_Human2.03126706
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.00681422
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00302253
45GATA2_19941826_ChIP-Seq_K562_Human2.00282669
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.97467843
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96830105
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94020767
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94008732
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.93327869
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92271333
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.90409120
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89527239
54MYB_26560356_Chip-Seq_TH2_Human1.88136113
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.86737078
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85512355
57VDR_24763502_ChIP-Seq_THP-1_Human1.84651677
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.83312719
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.79763344
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78438413
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78358802
62IGF1R_20145208_ChIP-Seq_DFB_Human1.75931692
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73205227
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71954347
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70267652
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68020130
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.63444490
68RARB_27405468_Chip-Seq_BRAIN_Mouse1.62683756
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61939049
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60828522
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54870046
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51333989
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.51167048
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49196129
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48119266
76UTX_26944678_Chip-Seq_JUKART_Human1.46830021
77* SPI1_20517297_ChIP-Seq_HL60_Human1.44846690
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44722294
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44112498
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.43447452
81LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43099650
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.41265012
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40953810
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40015914
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.39324614
86VDR_21846776_ChIP-Seq_THP-1_Human1.37570051
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.36556074
88BCL6_27268052_Chip-Seq_Bcells_Human1.36272967
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36167301
90MYC_22102868_ChIP-Seq_BL_Human1.35887691
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34641329
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32233850
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30945333
94GATA3_26560356_Chip-Seq_TH2_Human1.30603950
95AR_21572438_ChIP-Seq_LNCaP_Human1.30177143
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30078974
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29439514
98STAT1_20625510_ChIP-Seq_HELA_Human1.27862857
99POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27706793
100KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26975066
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26671322
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26591069
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26183330
104EED_16625203_ChIP-ChIP_MESCs_Mouse1.24523411
105P300_27268052_Chip-Seq_Bcells_Human1.22998133
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.21146513
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19893412
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17708213
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16738730
110NCOR1_26117541_ChIP-Seq_K562_Human1.16494382
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15469308
112* GATA3_27048872_Chip-Seq_THYMUS_Human1.15278753
113OCT4_19829295_ChIP-Seq_ESCs_Human1.15124338
114REST_21632747_ChIP-Seq_MESCs_Mouse1.14462234
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14402506
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13542671
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13542671
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13501349
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13490329
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.13340493
121SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.13202991
122ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11806508
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11021323
124FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10540154
125ETS1_22383799_ChIP-Seq_G1ME_Mouse1.10290891
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09010137
127P300_19829295_ChIP-Seq_ESCs_Human1.08227180
128RUNX_20019798_ChIP-Seq_JUKART_Human1.08046198
129ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08036937
130BCOR_27268052_Chip-Seq_Bcells_Human1.07007931
131TP53_16413492_ChIP-PET_HCT116_Human1.04782075
132SMAD4_21741376_ChIP-Seq_HESCs_Human1.04750560
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03701017
134SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03460338
135CBX2_27304074_Chip-Seq_ESCs_Mouse1.01962554
136CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01880898
137TP63_17297297_ChIP-ChIP_HaCaT_Human1.00948184
138GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00784287
139VDR_24787735_ChIP-Seq_THP-1_Human1.00595913
140* LXR_22292898_ChIP-Seq_THP-1_Human0.99536060
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98735774
142MYB_26560356_Chip-Seq_TH1_Human0.98491637
143CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98349981
144FUS_26573619_Chip-Seq_HEK293_Human0.98199359
145TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98037651
146RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97748067
147NANOG_20526341_ChIP-Seq_ESCs_Human0.97508594
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.96804107
149* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96634560
150VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96572912
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96246076
152RING1B_27294783_Chip-Seq_NPCs_Mouse0.95549236
153MAF_26560356_Chip-Seq_TH1_Human0.95218437
154ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95216274
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94741401
156ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94695526
157AR_20517297_ChIP-Seq_VCAP_Human0.94221071
158RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94168617
159RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93763180
160CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93191070
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92595421
162HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92304593
163GATA3_21878914_ChIP-Seq_MCF-7_Human0.91054678
164SMAD_19615063_ChIP-ChIP_OVARY_Human0.90626309
165PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90572340
166SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89939336
167EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89918851
168STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89706385
169EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88189388
170WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86838405
171TP53_18474530_ChIP-ChIP_U2OS_Human0.86118815
172PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85906583
173SRF_21415370_ChIP-Seq_HL-1_Mouse0.85615172
174NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85463936
175PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85026879
176TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84765216
177NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84504718
178CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83887768
179CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83756905
180SMRT_27268052_Chip-Seq_Bcells_Human0.82649041
181RNF2_27304074_Chip-Seq_NSC_Mouse0.81860435
182CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81217219
183LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.81079262
184EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78742664
185SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.78405896

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.03184744
2MP0004510_myositis6.51253899
3MP0004133_heterotaxia5.77245833
4MP0002254_reproductive_system_inflammat5.76887905
5MP0001851_eye_inflammation4.21090844
6MP0003724_increased_susceptibility_to4.17719812
7MP0001873_stomach_inflammation4.04857387
8MP0003941_abnormal_skin_development3.98733811
9MP0003303_peritoneal_inflammation3.71436013
10MP0002148_abnormal_hypersensitivity_rea3.24557239
11MP0008004_abnormal_stomach_pH3.12488605
12MP0003252_abnormal_bile_duct3.08763015
13MP0005397_hematopoietic_system_phenotyp3.03355485
14MP0001545_abnormal_hematopoietic_system3.03355485
15MP0005646_abnormal_pituitary_gland2.68018490
16MP0006082_CNS_inflammation2.52158901
17MP0009278_abnormal_bone_marrow2.47945092
18MP0005058_abnormal_lysosome_morphology2.46262429
19MP0005084_abnormal_gallbladder_morpholo2.39295504
20MP0001835_abnormal_antigen_presentation2.35835117
21MP0003806_abnormal_nucleotide_metabolis2.31820976
22MP0003436_decreased_susceptibility_to2.21197453
23MP0008877_abnormal_DNA_methylation2.08942805
24MP0002998_abnormal_bone_remodeling2.07315972
25MP0005000_abnormal_immune_tolerance2.01207531
26MP0003283_abnormal_digestive_organ10.5800530
27MP0005423_abnormal_somatic_nervous1.99855886
28MP0005671_abnormal_response_to1.89362428
29MP0001849_ear_inflammation1.83653457
30MP0002419_abnormal_innate_immunity1.81962852
31MP0010030_abnormal_orbit_morphology1.77583811
32MP0000230_abnormal_systemic_arterial1.74866060
33MP0002735_abnormal_chemical_nociception1.70793343
34MP0001340_abnormal_eyelid_morphology1.70768405
35MP0004859_abnormal_synaptic_plasticity1.65614240
36MP0004270_analgesia1.64840702
37MP0000343_altered_response_to1.64348260
38MP0008872_abnormal_physiological_respon1.61660514
39MP0002452_abnormal_antigen_presenting1.60627050
40MP0002933_joint_inflammation1.59109335
41MP0002398_abnormal_bone_marrow1.58602764
42MP0005410_abnormal_fertilization1.57739283
43MP0005025_abnormal_response_to1.57710317
44MP0001800_abnormal_humoral_immune1.54126369
45MP0002420_abnormal_adaptive_immunity1.52549843
46MP0001819_abnormal_immune_cell1.52415423
47MP0009765_abnormal_xenobiotic_induced1.51612795
48MP0001533_abnormal_skeleton_physiology1.51286415
49MP0001790_abnormal_immune_system1.39980693
50MP0005387_immune_system_phenotype1.39980693
51MP0001986_abnormal_taste_sensitivity1.39961142
52MP0004808_abnormal_hematopoietic_stem1.36941154
53MP0003172_abnormal_lysosome_physiology1.34747920
54MP0010155_abnormal_intestine_physiology1.32974410
55MP0005083_abnormal_biliary_tract1.32003241
56MP0009763_increased_sensitivity_to1.30108878
57MP0005167_abnormal_blood-brain_barrier1.30098023
58MP0002429_abnormal_blood_cell1.24788949
59MP0000716_abnormal_immune_system1.23705837
60MP0003221_abnormal_cardiomyocyte_apopto1.23677536
61MP0002722_abnormal_immune_system1.23367118
62MP0001845_abnormal_inflammatory_respons1.23341981
63MP0003828_pulmonary_edema1.22297033
64MP0004147_increased_porphyrin_level1.22174488
65MP0003656_abnormal_erythrocyte_physiolo1.21187669
66MP0003943_abnormal_hepatobiliary_system1.19360014
67MP0004885_abnormal_endolymph1.13437244
68MP0002405_respiratory_system_inflammati1.13197441
69MP0003635_abnormal_synaptic_transmissio1.10342169
70MP0005174_abnormal_tail_pigmentation1.09988085
71MP0002138_abnormal_hepatobiliary_system1.09459523
72MP0002396_abnormal_hematopoietic_system1.07314088
73MP0005670_abnormal_white_adipose1.05171167
74MP0003950_abnormal_plasma_membrane1.01343339
75MP0003718_maternal_effect1.00864745
76MP0001663_abnormal_digestive_system1.00464716
77MP0005394_taste/olfaction_phenotype0.99021192
78MP0005499_abnormal_olfactory_system0.99021192
79MP0008775_abnormal_heart_ventricle0.98931905
80MP0009046_muscle_twitch0.98493865
81MP0002139_abnormal_hepatobiliary_system0.96900166
82MP0009785_altered_susceptibility_to0.96378531
83MP0002075_abnormal_coat/hair_pigmentati0.96048927
84MP0006036_abnormal_mitochondrial_physio0.95505063
85MP0008469_abnormal_protein_level0.94648111
86MP0003938_abnormal_ear_development0.94111767
87MP0005165_increased_susceptibility_to0.94087336
88MP0005220_abnormal_exocrine_pancreas0.92132651
89MP0000249_abnormal_blood_vessel0.90418852
90MP0009697_abnormal_copulation0.90394239
91MP0000049_abnormal_middle_ear0.90317836
92MP0005248_abnormal_Harderian_gland0.90001837
93MP0004947_skin_inflammation0.89984944
94MP0002063_abnormal_learning/memory/cond0.88042878
95MP0003183_abnormal_peptide_metabolism0.86698649
96MP0000685_abnormal_immune_system0.86078898
97MP0001186_pigmentation_phenotype0.85691400
98MP0008789_abnormal_olfactory_epithelium0.84629991
99MP0005390_skeleton_phenotype0.83039837
100MP0002822_catalepsy0.82605136
101MP0005381_digestive/alimentary_phenotyp0.82244896
102MP0001970_abnormal_pain_threshold0.81454037
103MP0005503_abnormal_tendon_morphology0.80690016
104MP0001664_abnormal_digestion0.80642280
105MP0008873_increased_physiological_sensi0.80506259
106MP0009333_abnormal_splenocyte_physiolog0.80440076
107MP0005075_abnormal_melanosome_morpholog0.79333605
108MP0009745_abnormal_behavioral_response0.79317703
109MP0010329_abnormal_lipoprotein_level0.79298045
110MP0008874_decreased_physiological_sensi0.78377962
111MP0003880_abnormal_central_pattern0.77898974
112MP0003385_abnormal_body_wall0.77723547
113MP0005666_abnormal_adipose_tissue0.76761707
114MP0001502_abnormal_circadian_rhythm0.75985666
115MP0004036_abnormal_muscle_relaxation0.75787357
116MP0003763_abnormal_thymus_physiology0.74630837
117MP0000465_gastrointestinal_hemorrhage0.74434265
118MP0003075_altered_response_to0.74184185
119MP0004084_abnormal_cardiac_muscle0.73902704
120MP0002064_seizures0.73219896
121* MP0009642_abnormal_blood_homeostasis0.73142201
122MP0009840_abnormal_foam_cell0.72975982
123MP0004883_abnormal_blood_vessel0.72650742
124MP0001944_abnormal_pancreas_morphology0.72476410
125MP0002249_abnormal_larynx_morphology0.71686102
126MP0001529_abnormal_vocalization0.70937280
127MP0004272_abnormal_basement_membrane0.70752972
128MP0001486_abnormal_startle_reflex0.70065017
129MP0004185_abnormal_adipocyte_glucose0.69705192
130MP0002877_abnormal_melanocyte_morpholog0.68329781
131* MP0002557_abnormal_social/conspecific_i0.67865507
132MP0000566_synostosis0.67431957
133MP0006072_abnormal_retinal_apoptosis0.66651365
134MP0003795_abnormal_bone_structure0.66355833
135MP0000703_abnormal_thymus_morphology0.65931268
136MP0003300_gastrointestinal_ulcer0.65770333
137MP0005448_abnormal_energy_balance0.65180560
138* MP0002233_abnormal_nose_morphology0.64680168
139MP0002019_abnormal_tumor_incidence0.64607613
140MP0008058_abnormal_DNA_repair0.64505088
141MP0002132_abnormal_respiratory_system0.63769734
142MP0002733_abnormal_thermal_nociception0.63344015
143MP0003115_abnormal_respiratory_system0.61980220
144MP0001501_abnormal_sleep_pattern0.58780747
145* MP0002572_abnormal_emotion/affect_behav0.58490743
146MP0000778_abnormal_nervous_system0.57932925
147MP0002113_abnormal_skeleton_development0.54811761
148MP0001968_abnormal_touch/_nociception0.54483442
149MP0000470_abnormal_stomach_morphology0.54357142
150MP0003866_abnormal_defecation0.53561061
151* MP0002184_abnormal_innervation0.53382587
152MP0006276_abnormal_autonomic_nervous0.52559160
153MP0000534_abnormal_ureter_morphology0.52244316
154MP0005085_abnormal_gallbladder_physiolo0.52223850
155MP0002083_premature_death0.52052895
156MP0008569_lethality_at_weaning0.52019021
157MP0003787_abnormal_imprinting0.50174125
158MP0002932_abnormal_joint_morphology0.49719707
159MP0005360_urolithiasis0.49449097
160MP0005164_abnormal_response_to0.47037450
161MP0003638_abnormal_response/metabolism_0.47035204
162MP0002736_abnormal_nociception_after0.46548192
163MP0003879_abnormal_hair_cell0.46174369
164MP0005551_abnormal_eye_electrophysiolog0.44556446
165MP0000613_abnormal_salivary_gland0.44483161
166MP0002723_abnormal_immune_serum0.44370750
167MP0005501_abnormal_skin_physiology0.42027917
168* MP0002272_abnormal_nervous_system0.41202250
169MP0000955_abnormal_spinal_cord0.41172605
170MP0002090_abnormal_vision0.41068520
171MP0000689_abnormal_spleen_morphology0.40770224
172MP0004742_abnormal_vestibular_system0.40405811
173MP0001963_abnormal_hearing_physiology0.39847657
174MP0009764_decreased_sensitivity_to0.39833522
175MP0002067_abnormal_sensory_capabilities0.37753719
176MP0004085_abnormal_heartbeat0.36845566
177MP0000751_myopathy0.36704088
178MP0010386_abnormal_urinary_bladder0.35830293
179MP0005166_decreased_susceptibility_to0.35403533

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.03845130
2Abdominal situs inversus (HP:0003363)8.35712786
3Abnormality of abdominal situs (HP:0011620)8.35712786
4Petechiae (HP:0000967)8.15982859
5Entropion (HP:0000621)7.92742790
6Poikiloderma (HP:0001029)7.36742627
7Purpura (HP:0000979)7.31609433
8Menorrhagia (HP:0000132)7.10828315
9Increased mean platelet volume (HP:0011877)7.05695746
10Abnormal platelet volume (HP:0011876)6.71273148
11Epistaxis (HP:0000421)6.31447671
12Striae distensae (HP:0001065)6.08290935
13Constricted visual fields (HP:0001133)5.08990438
14Abnormality of DNA repair (HP:0003254)5.08080949
15Limb hypertonia (HP:0002509)4.84771501
16Oligodontia (HP:0000677)4.75108760
17Abnormal ventriculo-arterial connection (HP:0011563)4.66030359
18Transposition of the great arteries (HP:0001669)4.66030359
19Abnormal connection of the cardiac segments (HP:0011545)4.66030359
20Stillbirth (HP:0003826)4.65577088
21Truncus arteriosus (HP:0001660)4.63331874
22Gingival bleeding (HP:0000225)4.59273141
23Abnormal sex determination (HP:0012244)4.51701359
24Sex reversal (HP:0012245)4.51701359
25True hermaphroditism (HP:0010459)4.32529015
26Abnormal platelet function (HP:0011869)4.15119004
27Impaired platelet aggregation (HP:0003540)4.15119004
28Failure to thrive in infancy (HP:0001531)4.06600141
29Ectropion (HP:0000656)3.96441198
30Chin dimple (HP:0010751)3.95637943
31Hyperlipoproteinemia (HP:0010980)3.94419393
32Spontaneous hematomas (HP:0007420)3.73264285
33Abnormality of the periventricular white matter (HP:0002518)3.49058931
34Stomatitis (HP:0010280)3.41972312
35Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.40540161
36Elevated erythrocyte sedimentation rate (HP:0003565)3.39813757
37Dyschromatopsia (HP:0007641)3.39360499
38Late onset (HP:0003584)3.26287945
39Ankyloglossia (HP:0010296)3.23926230
40Hepatosplenomegaly (HP:0001433)3.21283899
41Abnormality of the prostate (HP:0008775)3.20992093
42Decreased central vision (HP:0007663)3.18682213
43Absent rod-and cone-mediated responses on ERG (HP:0007688)3.17465230
44Increased neuronal autofluorescent lipopigment (HP:0002074)3.16908052
45Male infertility (HP:0003251)3.16377437
46Dysostosis multiplex (HP:0000943)3.10743471
47Increased cerebral lipofuscin (HP:0011813)3.04537052
48Abnormality of the vasculature of the conjunctiva (HP:0008054)2.99662472
49Atrioventricular canal defect (HP:0006695)2.99147477
50Genetic anticipation (HP:0003743)2.85741985
51Childhood onset (HP:0011463)2.85059158
52Autoimmune thrombocytopenia (HP:0001973)2.84509254
53Chronic obstructive pulmonary disease (HP:0006510)2.84106379
54Obstructive lung disease (HP:0006536)2.84106379
55Progressive inability to walk (HP:0002505)2.83869819
56Abnormality of transition element cation homeostasis (HP:0011030)2.83483798
57Abnormality of iron homeostasis (HP:0011031)2.76007522
58Abnormality of macrophages (HP:0004311)2.70151190
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.64553892
60Abnormal hair whorl (HP:0010721)2.63807464
61Conjunctival telangiectasia (HP:0000524)2.63548550
62Annular pancreas (HP:0001734)2.63073917
63Lack of skin elasticity (HP:0100679)2.63013444
64Pigmentary retinal degeneration (HP:0001146)2.60698052
65Flat cornea (HP:0007720)2.58193878
66Increased serum ferritin (HP:0003281)2.58185524
67Bruising susceptibility (HP:0000978)2.57457182
68Abnormality of lateral ventricle (HP:0030047)2.55146788
69Poikilocytosis (HP:0004447)2.54320736
70Thrombocytosis (HP:0001894)2.47469090
71Increased IgM level (HP:0003496)2.47343686
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.46670134
73Progressive cerebellar ataxia (HP:0002073)2.44086382
74Type 2 muscle fiber atrophy (HP:0003554)2.43354987
75Abnormality of the heme biosynthetic pathway (HP:0010472)2.42588612
76Episodic fever (HP:0001954)2.41196940
77Intrahepatic cholestasis (HP:0001406)2.40287182
78Autoimmune hemolytic anemia (HP:0001890)2.38304369
79Muscle fiber atrophy (HP:0100295)2.37041776
80Abnormality of oral frenula (HP:0000190)2.36222603
81Attenuation of retinal blood vessels (HP:0007843)2.30708607
82Progressive microcephaly (HP:0000253)2.29942183
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.29817774
84Panhypogammaglobulinemia (HP:0003139)2.25608411
85Squamous cell carcinoma (HP:0002860)2.24632559
86Occipital encephalocele (HP:0002085)2.22602175
87Joint swelling (HP:0001386)2.14644485
88Acanthocytosis (HP:0001927)2.12682037
89Abnormality of methionine metabolism (HP:0010901)2.11816494
90Leukocytosis (HP:0001974)2.11483172
91Abnormality of B cell number (HP:0010975)2.09127016
92Keratitis (HP:0000491)2.09099887
93Visual hallucinations (HP:0002367)2.08913767
94Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07677771
95Granulocytopenia (HP:0001913)2.06645804
96Vacuolated lymphocytes (HP:0001922)2.06428918
97Chest pain (HP:0100749)2.05635449
98Recurrent abscess formation (HP:0002722)2.05190410
99Thickened calvaria (HP:0002684)2.05055077
100Round face (HP:0000311)2.04683288
101Testicular neoplasm (HP:0010788)2.03774141
102Encephalitis (HP:0002383)2.02708977
103Basal ganglia calcification (HP:0002135)2.00392554
104Double outlet right ventricle (HP:0001719)10.2537595
105Congenital malformation of the right heart (HP:0011723)10.2537595
106Abnormal pancreas size (HP:0012094)1.99409467
107Abolished electroretinogram (ERG) (HP:0000550)1.97735839
108Arterial thrombosis (HP:0004420)1.94055496
109Paralysis (HP:0003470)1.93559002
110Vasculitis (HP:0002633)1.92081399
111Abnormality of the common coagulation pathway (HP:0010990)1.92027302
112Myositis (HP:0100614)1.91424452
113Hyperventilation (HP:0002883)1.90376386
114Abnormal pupillary function (HP:0007686)1.87023074
115Recurrent bacterial skin infections (HP:0005406)1.86139197
116Eosinophilia (HP:0001880)1.85193836
117Abnormal rod and cone electroretinograms (HP:0008323)1.83531020
118Intellectual disability, profound (HP:0002187)1.82157960
119Slow saccadic eye movements (HP:0000514)1.81290847
120Myopathic facies (HP:0002058)1.80297652
121Meningitis (HP:0001287)1.79893446
122Neonatal hypoglycemia (HP:0001998)1.79389353
123Tubulointerstitial nephritis (HP:0001970)1.77942647
124Asymmetric septal hypertrophy (HP:0001670)1.77696534
125Vertigo (HP:0002321)1.76882819
126Mucopolysacchariduria (HP:0008155)1.75507955
127Urinary glycosaminoglycan excretion (HP:0003541)1.75507955
128Weak cry (HP:0001612)1.74142799
129Pulmonary fibrosis (HP:0002206)1.73842035
130Pulmonary embolism (HP:0002204)1.73055995
131Agammaglobulinemia (HP:0004432)1.73007401
132Systemic lupus erythematosus (HP:0002725)1.72872932
133Hypothermia (HP:0002045)1.71365158
134Arterial tortuosity (HP:0005116)1.70577058
135Renal Fanconi syndrome (HP:0001994)1.70291234
136Poor speech (HP:0002465)1.69206091
1373-Methylglutaconic aciduria (HP:0003535)1.68626129
138Recurrent fungal infections (HP:0002841)1.68150639
139Delayed myelination (HP:0012448)1.67974434
140Abnormality of the costochondral junction (HP:0000919)1.67668402
141Abnormality of eosinophils (HP:0001879)1.66095081
142Thrombophlebitis (HP:0004418)1.66037142
143Dysautonomia (HP:0002459)1.65905169
144Orchitis (HP:0100796)1.65821651
145Recurrent viral infections (HP:0004429)1.65682646
146Spondylolisthesis (HP:0003302)1.65097081
147Eczematoid dermatitis (HP:0000976)1.63043363
148Abnormality of aspartate family amino acid metabolism (HP:0010899)1.61543459
149Clonus (HP:0002169)1.60212039
150Generalized aminoaciduria (HP:0002909)1.58945454
151Postural tremor (HP:0002174)1.58891782
152Abnormality of mucopolysaccharide metabolism (HP:0011020)1.58807963
153Abnormality of polysaccharide metabolism (HP:0011012)1.58807963
154Abnormality of glycosaminoglycan metabolism (HP:0004371)1.58807963
155Absent frontal sinuses (HP:0002688)1.58788137
156Febrile seizures (HP:0002373)1.58638168
157Chronic otitis media (HP:0000389)1.58608046
158Tinnitus (HP:0000360)1.57707625
159Gonadal dysgenesis (HP:0000133)1.57591053
160Bifid scrotum (HP:0000048)1.57090551
161Hyperthyroidism (HP:0000836)1.56893462
162Anhidrosis (HP:0000970)1.56020407
163Nausea (HP:0002018)1.55623856
164Fatigable weakness (HP:0003473)1.55290334
165Abnormality of the neuromuscular junction (HP:0003398)1.55290334
166Abnormality of the fingertips (HP:0001211)1.54815044
167Bifid uvula (HP:0000193)1.54586941
168Gowers sign (HP:0003391)1.53254710
169J-shaped sella turcica (HP:0002680)1.51995254
170Mask-like facies (HP:0000298)1.51980609
171Male pseudohermaphroditism (HP:0000037)1.51255906
172Optic neuritis (HP:0100653)1.49313679
173Retrobulbar optic neuritis (HP:0100654)1.49313679
174Hypophosphatemic rickets (HP:0004912)1.49300025
175Nonprogressive disorder (HP:0003680)1.48962529
176B lymphocytopenia (HP:0010976)1.48031806
177Progressive hearing impairment (HP:0001730)1.46632751
178Decreased muscle mass (HP:0003199)1.46506492
179Esophageal atresia (HP:0002032)1.46052461
180Irritability (HP:0000737)1.45932213
181Progressive neurologic deterioration (HP:0002344)1.45789206
182Abnormal biliary tract physiology (HP:0012439)1.45771254
183Bile duct proliferation (HP:0001408)1.45771254
184Septo-optic dysplasia (HP:0100842)1.44815713
185Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.44656005
186Degeneration of the lateral corticospinal tracts (HP:0002314)1.44656005
187Agitation (HP:0000713)1.44249434
188Deep venous thrombosis (HP:0002625)1.44147524
189Abnormality of male internal genitalia (HP:0000022)1.44113622
190Sensory axonal neuropathy (HP:0003390)1.43794164
191Vascular tortuosity (HP:0004948)1.40753618
192Centrally nucleated skeletal muscle fibers (HP:0003687)1.33446524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K37.76679873
2MAP3K36.60300160
3KIT5.35933947
4CDK195.13736898
5PRKD24.08612804
6TRIB34.04023109
7TAOK33.97152915
8TRIM283.75864614
9MAP4K23.58695874
10SGK23.03624148
11TNK22.72108562
12SGK4942.52804320
13SGK2232.52804320
14PRKCH2.51712068
15BCKDK2.29933522
16MATK2.20495252
17BMX2.19234222
18FES2.16009245
19SGK32.15660872
20GRK61.97315616
21PIK3CG1.94255595
22NME21.69012324
23MAP4K11.67399928
24MST41.65533206
25TLK11.62857430
26ADRBK21.60825181
27IRAK31.60246969
28IKBKB1.57153803
29TIE11.51714238
30TGFBR21.49024949
31MAP3K41.48074124
32ZAP701.47424214
33NUAK11.38837856
34TRPM71.34693931
35PTK2B1.33561040
36DAPK21.31616816
37BMPR21.30306295
38MAP2K71.28792288
39ZAK1.26029260
40MAP2K41.25833234
41MAPKAPK51.21295107
42LYN1.21267533
43EIF2AK11.17568139
44VRK21.10167518
45KDR1.10037773
46MAPKAPK31.09806802
47SYK1.07404091
48PIM21.06638574
49ERN10.97600365
50ILK0.93843637
51ITK0.92208829
52PAK20.90568487
53MUSK0.87051184
54ADRBK10.86472214
55MARK30.86213651
56MAP3K100.85401339
57FGR0.83104743
58CDK120.82949759
59IRAK20.82927640
60MAP3K110.82776515
61IRAK10.82668345
62TAOK20.81566946
63BLK0.80085186
64LCK0.79182292
65PRKCQ0.78070903
66DAPK10.77385159
67IRAK40.73026707
68CSK0.72295650
69MKNK10.71485578
70SCYL20.71079977
71DAPK30.69860868
72MAP3K90.69319776
73PRKCE0.68291659
74ACVR1B0.66244456
75MAP2K20.63811667
76BRD40.59318054
77MARK10.58765985
78RIPK40.57997017
79CSF1R0.55157018
80CAMKK20.54307607
81CASK0.53767160
82MAP3K50.52739950
83CDK90.52478102
84FER0.52465650
85MAP2K60.51033021
86PAK10.50548339
87NEK90.49405771
88GRK70.49241949
89VRK10.49165697
90TNIK0.48945569
91TESK20.48909499
92EGFR0.48709341
93GSK3A0.48220480
94PINK10.47915595
95FRK0.46534335
96JAK20.45428371
97PIM10.44790130
98TBK10.44459574
99PKN20.44300268
100MAP3K130.44064974
101TAOK10.43506953
102PRKCD0.42074534
103MAP2K10.40347084
104DYRK20.39796274
105NTRK20.39491401
106PRKG20.39455289
107MAPK130.38714183
108UHMK10.37443278
109EPHB20.37266592
110MAP3K120.36802036
111PRKAA20.36573662
112MAP3K70.36453462
113HIPK20.36231823
114SGK10.36041823
115PDK10.35772179
116MAP3K140.34833547
117STK160.34548255
118SIK10.30431789
119MINK10.30142023
120CDK50.29632149
121BTK0.29480318
122ABL10.27728478
123IGF1R0.27570229
124CHUK0.26018420
125MAPK120.25989716
126CDK60.25258461
127PRKACG0.24564747
128PRKD10.24468324
129WNK30.24341055
130MARK20.24211043
131TEC0.23292609
132CAMK2B0.22537466
133RPS6KB20.22232363
134PHKG10.19889664
135PHKG20.19889664
136CAMK2D0.19133938
137MAPK30.18593068
138GRK50.18443106
139PRKCA0.16251393
140PRKACA0.15779599
141PDPK10.15766370
142CAMK2A0.15082219
143FLT30.14045838
144RPS6KA50.13876342
145PKN10.13694334
146NTRK30.13304955
147RPS6KA30.12512992
148MYLK0.12502242
149ABL20.12449588
150RET0.12294743
151MTOR0.12192543
152HCK0.11935357
153MAPK40.11754809
154TTN0.11489159
155STK100.11389042
156JAK30.11281456
157PAK60.11078792
158MAPKAPK20.10669164
159PRKACB0.10660181
160MOS0.09752584
161IKBKE0.09741587
162ERBB30.09357481
163CDK11A0.09281820
164INSR0.09196646
165EPHA40.09043307
166TXK0.08985539
167SIK30.08874582

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004505.13813965
2Asthma_Homo sapiens_hsa053104.26545334
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.82247722
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.79978407
5Allograft rejection_Homo sapiens_hsa053302.62488666
6GnRH signaling pathway_Homo sapiens_hsa049122.40808463
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.40603665
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.32217272
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.26318686
10Arachidonic acid metabolism_Homo sapiens_hsa005902.25363683
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14530099
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10518395
13Staphylococcus aureus infection_Homo sapiens_hsa051502.07700822
14Autoimmune thyroid disease_Homo sapiens_hsa053202.05828404
15Glutamatergic synapse_Homo sapiens_hsa047241.95846092
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95417004
17Graft-versus-host disease_Homo sapiens_hsa053321.89652529
18Nicotine addiction_Homo sapiens_hsa050331.83095439
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80977006
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.80052581
21Olfactory transduction_Homo sapiens_hsa047401.80035179
22Leishmaniasis_Homo sapiens_hsa051401.70520412
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70109649
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.68299766
25GABAergic synapse_Homo sapiens_hsa047271.65393001
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62644788
27Renin-angiotensin system_Homo sapiens_hsa046141.59700112
28Circadian entrainment_Homo sapiens_hsa047131.59474486
29Type I diabetes mellitus_Homo sapiens_hsa049401.58059617
30Butanoate metabolism_Homo sapiens_hsa006501.57093839
31Other glycan degradation_Homo sapiens_hsa005111.56163674
32Serotonergic synapse_Homo sapiens_hsa047261.52133814
33Morphine addiction_Homo sapiens_hsa050321.49450944
34Systemic lupus erythematosus_Homo sapiens_hsa053221.47053201
35MAPK signaling pathway_Homo sapiens_hsa040101.43325126
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38786097
37Tryptophan metabolism_Homo sapiens_hsa003801.37029169
38Primary immunodeficiency_Homo sapiens_hsa053401.35502506
39Mismatch repair_Homo sapiens_hsa034301.34653619
40Rheumatoid arthritis_Homo sapiens_hsa053231.33694219
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32872210
42Taste transduction_Homo sapiens_hsa047421.28135755
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26256884
44Lysosome_Homo sapiens_hsa041421.22224673
45Salivary secretion_Homo sapiens_hsa049701.21642773
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21391013
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21379664
48Dopaminergic synapse_Homo sapiens_hsa047281.17661675
49Dorso-ventral axis formation_Homo sapiens_hsa043201.17364380
50Fatty acid degradation_Homo sapiens_hsa000711.16439443
51Linoleic acid metabolism_Homo sapiens_hsa005911.15488629
52p53 signaling pathway_Homo sapiens_hsa041151.14825977
53African trypanosomiasis_Homo sapiens_hsa051431.12827414
54B cell receptor signaling pathway_Homo sapiens_hsa046621.11953806
55Osteoclast differentiation_Homo sapiens_hsa043801.09665016
56Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09482173
57Malaria_Homo sapiens_hsa051441.09099563
58Nitrogen metabolism_Homo sapiens_hsa009101.08720241
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.08530218
60Calcium signaling pathway_Homo sapiens_hsa040201.04255500
61Renin secretion_Homo sapiens_hsa049241.03880863
62Chemokine signaling pathway_Homo sapiens_hsa040621.03267260
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00855777
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00798647
65Choline metabolism in cancer_Homo sapiens_hsa052310.99331604
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99052615
67Non-small cell lung cancer_Homo sapiens_hsa052230.98787037
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98170257
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96630834
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95961176
71Antigen processing and presentation_Homo sapiens_hsa046120.95081496
72Platelet activation_Homo sapiens_hsa046110.94607505
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93631425
74Synaptic vesicle cycle_Homo sapiens_hsa047210.93474309
75Biosynthesis of amino acids_Homo sapiens_hsa012300.92061058
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.91693237
77Legionellosis_Homo sapiens_hsa051340.91431855
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89443694
79Lysine degradation_Homo sapiens_hsa003100.89011227
80Phototransduction_Homo sapiens_hsa047440.88376056
81Cholinergic synapse_Homo sapiens_hsa047250.88102325
82Folate biosynthesis_Homo sapiens_hsa007900.87447267
83Insulin secretion_Homo sapiens_hsa049110.87042331
84Base excision repair_Homo sapiens_hsa034100.86849113
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86135166
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85782357
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83880090
88Tuberculosis_Homo sapiens_hsa051520.82565594
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82018165
90Ovarian steroidogenesis_Homo sapiens_hsa049130.81000252
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.79744014
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78948639
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78198220
94Herpes simplex infection_Homo sapiens_hsa051680.77123143
95Histidine metabolism_Homo sapiens_hsa003400.76822067
96Long-term depression_Homo sapiens_hsa047300.76570128
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.76245663
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75971233
99Thyroid hormone synthesis_Homo sapiens_hsa049180.75346262
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75263369
101Oxytocin signaling pathway_Homo sapiens_hsa049210.73807818
102Fatty acid metabolism_Homo sapiens_hsa012120.73285683
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73145487
104Glycerolipid metabolism_Homo sapiens_hsa005610.72967798
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72718145
106Toxoplasmosis_Homo sapiens_hsa051450.72250533
107Ras signaling pathway_Homo sapiens_hsa040140.71358231
108Alcoholism_Homo sapiens_hsa050340.69898995
109Regulation of autophagy_Homo sapiens_hsa041400.69307475
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.67950005
111Dilated cardiomyopathy_Homo sapiens_hsa054140.67591810
112Sulfur metabolism_Homo sapiens_hsa009200.67496771
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64766266
114Chronic myeloid leukemia_Homo sapiens_hsa052200.64492597
115ECM-receptor interaction_Homo sapiens_hsa045120.64298065
116Amphetamine addiction_Homo sapiens_hsa050310.64051301
117Pertussis_Homo sapiens_hsa051330.63645641
118Peroxisome_Homo sapiens_hsa041460.63025777
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62187558
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61036494
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60992218
122Shigellosis_Homo sapiens_hsa051310.60409122
123Propanoate metabolism_Homo sapiens_hsa006400.59999867
124Prolactin signaling pathway_Homo sapiens_hsa049170.57929338
125Glutathione metabolism_Homo sapiens_hsa004800.57785082
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57642584
127Arginine biosynthesis_Homo sapiens_hsa002200.57390778
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.57060818
129Chemical carcinogenesis_Homo sapiens_hsa052040.56577734
130Viral myocarditis_Homo sapiens_hsa054160.56561402
131Influenza A_Homo sapiens_hsa051640.55710117
132Phagosome_Homo sapiens_hsa041450.55475274
133T cell receptor signaling pathway_Homo sapiens_hsa046600.55164093
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55076627
135beta-Alanine metabolism_Homo sapiens_hsa004100.55013636
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54835686
137Acute myeloid leukemia_Homo sapiens_hsa052210.54557725
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54225666
139Gap junction_Homo sapiens_hsa045400.52637943
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.51570782
141Starch and sucrose metabolism_Homo sapiens_hsa005000.51331070
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51208062
143Collecting duct acid secretion_Homo sapiens_hsa049660.51122640
144Long-term potentiation_Homo sapiens_hsa047200.49794196
145Mineral absorption_Homo sapiens_hsa049780.49778837
146VEGF signaling pathway_Homo sapiens_hsa043700.48466311
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47385415
148Hematopoietic cell lineage_Homo sapiens_hsa046400.45653067
149Cocaine addiction_Homo sapiens_hsa050300.45593818
150Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45564882
151RNA polymerase_Homo sapiens_hsa030200.45003983
152Fatty acid elongation_Homo sapiens_hsa000620.44453851
153Fanconi anemia pathway_Homo sapiens_hsa034600.43648367
154Axon guidance_Homo sapiens_hsa043600.43596524
155Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42946919
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42681541
157Pancreatic secretion_Homo sapiens_hsa049720.42387981
158Carbon metabolism_Homo sapiens_hsa012000.41790988
159Apoptosis_Homo sapiens_hsa042100.41730077
160Adipocytokine signaling pathway_Homo sapiens_hsa049200.41292195
161Rap1 signaling pathway_Homo sapiens_hsa040150.40919938
162cAMP signaling pathway_Homo sapiens_hsa040240.39572937
163Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39088069
164Ether lipid metabolism_Homo sapiens_hsa005650.37072640
165ErbB signaling pathway_Homo sapiens_hsa040120.36951542
166Complement and coagulation cascades_Homo sapiens_hsa046100.36735431
167Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34513084
168Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33990920
169Endometrial cancer_Homo sapiens_hsa052130.33184259

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