TRPC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)9.16823322
2positive regulation of phosphoprotein phosphatase activity (GO:0032516)6.26690718
3neuronal action potential propagation (GO:0019227)5.71022918
4C4-dicarboxylate transport (GO:0015740)5.67343255
5metanephric tubule development (GO:0072170)5.35595659
6metanephric nephron tubule development (GO:0072234)5.35595659
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.26110643
8regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.18474910
9protein heterotetramerization (GO:0051290)5.15274072
10cerebellar Purkinje cell layer development (GO:0021680)5.15096417
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.12268781
12retinal cone cell development (GO:0046549)5.06338564
13locomotory exploration behavior (GO:0035641)4.97166102
14synaptic vesicle maturation (GO:0016188)4.93808627
15response to histamine (GO:0034776)4.92328079
16retina layer formation (GO:0010842)4.83936324
17metanephric nephron epithelium development (GO:0072243)4.81168318
18relaxation of smooth muscle (GO:0044557)4.79250520
19inositol phosphate-mediated signaling (GO:0048016)4.73067601
20collecting duct development (GO:0072044)4.72275070
21vocalization behavior (GO:0071625)4.69831078
22cerebellar Purkinje cell differentiation (GO:0021702)4.69271621
23synaptic vesicle exocytosis (GO:0016079)4.68649546
24cerebellar granule cell differentiation (GO:0021707)4.66771788
25gamma-aminobutyric acid transport (GO:0015812)4.66707780
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.57451994
27regulation of synaptic vesicle exocytosis (GO:2000300)4.54166666
28glutamate secretion (GO:0014047)4.51773790
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.49487944
30multicellular organismal movement (GO:0050879)4.44202128
31musculoskeletal movement (GO:0050881)4.44202128
32fructose metabolic process (GO:0006000)4.42251143
33cellular potassium ion homeostasis (GO:0030007)4.42004995
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.41472466
35relaxation of cardiac muscle (GO:0055119)4.41270971
36metanephric epithelium development (GO:0072207)4.38185733
37glutamate receptor signaling pathway (GO:0007215)4.33491772
38positive regulation of dendritic spine morphogenesis (GO:0061003)4.31430172
39positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.28239050
40neurofilament cytoskeleton organization (GO:0060052)4.25224009
41neurotransmitter secretion (GO:0007269)4.22217300
42behavioral response to nicotine (GO:0035095)4.19670196
43membrane depolarization during action potential (GO:0086010)4.19332649
44sodium ion export (GO:0071436)4.18254965
45synaptic transmission, glutamatergic (GO:0035249)4.17101551
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.15639929
47layer formation in cerebral cortex (GO:0021819)4.12708707
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.04711351
49protein localization to synapse (GO:0035418)3.98439644
50synaptic vesicle docking involved in exocytosis (GO:0016081)3.97229047
51negative regulation of heart rate (GO:0010459)3.94502716
52neuron-neuron synaptic transmission (GO:0007270)3.92596076
53regulation of glutamate receptor signaling pathway (GO:1900449)3.92564426
54regulation of synaptic vesicle transport (GO:1902803)3.92563320
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.87817091
56proline transport (GO:0015824)3.82878927
57negative regulation of norepinephrine secretion (GO:0010700)3.77766457
58dopamine biosynthetic process (GO:0042416)3.74137203
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.72314852
60relaxation of muscle (GO:0090075)3.72104366
61cell differentiation in hindbrain (GO:0021533)3.70901701
62neuron cell-cell adhesion (GO:0007158)3.70864571
63negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.64551635
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.63529534
65exploration behavior (GO:0035640)3.63072938
66G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.60620540
67positive regulation of synapse maturation (GO:0090129)3.59168011
68neuronal action potential (GO:0019228)3.56995145
69response to pheromone (GO:0019236)3.56224765
70potassium ion import (GO:0010107)3.55239454
71cell communication by electrical coupling (GO:0010644)3.51378614
72positive regulation of glomerulus development (GO:0090193)3.50806858
73neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.50188321
74regulation of synapse structural plasticity (GO:0051823)3.50015951
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48648254
76regulation of excitatory postsynaptic membrane potential (GO:0060079)3.45095091
77cell communication involved in cardiac conduction (GO:0086065)3.44855035
78positive regulation of potassium ion transmembrane transport (GO:1901381)3.43014078
79regulation of potassium ion transmembrane transporter activity (GO:1901016)3.40877571
80membrane depolarization (GO:0051899)3.40354333
81negative regulation of dendrite morphogenesis (GO:0050774)3.37614553
82activation of protein kinase A activity (GO:0034199)3.37386570
83aggressive behavior (GO:0002118)3.37339108
84neurotransmitter transport (GO:0006836)3.36097490
85positive regulation of amino acid transport (GO:0051957)3.36021158
86regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33215303
87positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31870443
88auditory receptor cell stereocilium organization (GO:0060088)3.31728030
89neuromuscular process controlling balance (GO:0050885)3.31490848
90regulation of cell communication by electrical coupling (GO:0010649)3.31342789
91regulation of voltage-gated calcium channel activity (GO:1901385)3.30748322
92regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.28969200
93neuromuscular process controlling posture (GO:0050884)3.27436583
94long-term memory (GO:0007616)3.27423135
95cell migration in hindbrain (GO:0021535)3.27031158
96regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.26545926
97regulation of postsynaptic membrane potential (GO:0060078)3.26153633
98neurotransmitter-gated ion channel clustering (GO:0072578)3.25780702
99transmission of nerve impulse (GO:0019226)3.25496615
100negative regulation of catecholamine secretion (GO:0033604)3.24054142
101regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.22838786
102regulation of synaptic transmission, glutamatergic (GO:0051966)3.21752312
103axonal fasciculation (GO:0007413)3.20437593
104cGMP metabolic process (GO:0046068)3.20400518
105negative regulation of fatty acid transport (GO:2000192)3.19548762
106regulation of neuronal synaptic plasticity (GO:0048168)3.17718410
107regulation of neurotransmitter secretion (GO:0046928)3.17072482
108chemosensory behavior (GO:0007635)3.16579801
109membrane repolarization (GO:0086009)3.15602402
110glycine transport (GO:0015816)3.13383861
111presynaptic membrane organization (GO:0097090)3.13267650
112membrane hyperpolarization (GO:0060081)3.13099717
113prepulse inhibition (GO:0060134)3.11319715
114positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.10211840
115negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.10104494
116regulation of potassium ion transmembrane transport (GO:1901379)3.08682241
117nephron tubule development (GO:0072080)3.08348811
118regulation of axon regeneration (GO:0048679)3.07699243
119regulation of neuron projection regeneration (GO:0070570)3.07699243
120synapse assembly (GO:0007416)3.07131854
121dendrite morphogenesis (GO:0048813)3.05840133
122detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.05573546
123detection of temperature stimulus involved in sensory perception (GO:0050961)3.05573546
124regulation of neurotransmitter levels (GO:0001505)3.04865101
125dendritic spine morphogenesis (GO:0060997)3.04141353
126inner ear receptor stereocilium organization (GO:0060122)3.02000227
127adult walking behavior (GO:0007628)3.01694983
128negative regulation of microtubule polymerization (GO:0031115)3.01056042
129positive regulation of potassium ion transport (GO:0043268)2.99918821
130positive regulation of membrane potential (GO:0045838)2.98516281
131neuron recognition (GO:0008038)2.96177413
132innervation (GO:0060384)2.95972283
133presynaptic membrane assembly (GO:0097105)2.95617708
134neuromuscular synaptic transmission (GO:0007274)2.94290139
135regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93068514
136regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.92056556
137positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.91967561
138serotonin metabolic process (GO:0042428)2.90813149
139cerebral cortex radially oriented cell migration (GO:0021799)2.90808232
140auditory behavior (GO:0031223)2.90701270
141potassium ion homeostasis (GO:0055075)2.90223085
142synaptic vesicle endocytosis (GO:0048488)2.89796442
143heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.89643734
144cellular sodium ion homeostasis (GO:0006883)2.88767583
145detection of calcium ion (GO:0005513)2.88138199
146neuromuscular process (GO:0050905)2.87950889
147synaptic transmission (GO:0007268)2.87821132
148regulation of dendritic spine morphogenesis (GO:0061001)2.85730864
149negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85681896
150sodium ion homeostasis (GO:0055078)2.85163659
151regulation of neurotransmitter transport (GO:0051588)2.84562527
152behavioral response to cocaine (GO:0048148)2.84211122
153regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.83519835
154detection of temperature stimulus (GO:0016048)2.83337223
155response to ammonium ion (GO:0060359)2.81762415
156central nervous system development (GO:0007417)2.80185800
157acidic amino acid transport (GO:0015800)2.78207341
158cellular response to ammonium ion (GO:0071242)2.76975600
159endocrine hormone secretion (GO:0060986)2.76564500
160regulation of Rac GTPase activity (GO:0032314)2.75552293
161cellular response to electrical stimulus (GO:0071257)2.75502664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.25693113
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.31629495
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15033399
4GBX2_23144817_ChIP-Seq_PC3_Human3.15014907
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00675093
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91837920
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91837920
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.77560269
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71958963
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71630101
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66606490
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.63901999
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59993879
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57616530
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55788741
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.53127572
17* REST_21632747_ChIP-Seq_MESCs_Mouse2.51884074
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44561189
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.41781265
20FUS_26573619_Chip-Seq_HEK293_Human2.40146254
21DROSHA_22980978_ChIP-Seq_HELA_Human2.35626506
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35240700
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.29484228
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18293731
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.14572457
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.14233813
27* RNF2_27304074_Chip-Seq_ESCs_Mouse2.09532383
28* REST_18959480_ChIP-ChIP_MESCs_Mouse2.05139185
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97575931
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96318209
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90536334
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87243196
33CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83487427
34TAF15_26573619_Chip-Seq_HEK293_Human1.79332430
35* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75384286
36AR_21572438_ChIP-Seq_LNCaP_Human1.74206626
37SMAD4_21799915_ChIP-Seq_A2780_Human1.72573562
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71500041
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.69749907
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66967054
41EWS_26573619_Chip-Seq_HEK293_Human1.66555807
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56312759
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54120362
44ZNF274_21170338_ChIP-Seq_K562_Hela1.52121315
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46768013
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43284437
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.42507994
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40970993
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40651936
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38381729
51LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38210171
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37023991
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36818230
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36501728
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35474484
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33345079
57CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.33329502
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.31045857
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30603848
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28009125
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.26000886
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25063893
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.25006073
64* P300_19829295_ChIP-Seq_ESCs_Human1.24901590
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.24702986
66* AR_19668381_ChIP-Seq_PC3_Human1.23446093
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23285026
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22289633
69* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21956797
70AR_25329375_ChIP-Seq_VCAP_Human1.21717593
71STAT3_23295773_ChIP-Seq_U87_Human1.21498920
72VDR_22108803_ChIP-Seq_LS180_Human1.19982283
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19215619
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15812204
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.15618256
76IGF1R_20145208_ChIP-Seq_DFB_Human1.15398294
77SOX9_26525672_Chip-Seq_HEART_Mouse1.15199932
78AHR_22903824_ChIP-Seq_MCF-7_Human1.14306163
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.13928971
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12902325
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.11765398
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11549962
83* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11434547
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.11059805
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10016590
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09586658
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09487944
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08822844
89TP53_18474530_ChIP-ChIP_U2OS_Human1.08708351
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.08695681
91* KDM2B_26808549_Chip-Seq_K562_Human1.08448161
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.07420275
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07174593
94JUN_21703547_ChIP-Seq_K562_Human1.06796116
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05780804
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05372120
97HTT_18923047_ChIP-ChIP_STHdh_Human1.05078715
98ESR1_20079471_ChIP-ChIP_T-47D_Human1.04979311
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04919011
100SMAD4_21741376_ChIP-Seq_HESCs_Human1.04315689
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04072880
102TCF4_23295773_ChIP-Seq_U87_Human1.03742311
103* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03193330
104TCF4_22108803_ChIP-Seq_LS180_Human1.03092982
105ER_23166858_ChIP-Seq_MCF-7_Human1.02727627
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02028009
107CBP_20019798_ChIP-Seq_JUKART_Human1.02028009
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01460563
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01298383
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00979449
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99955975
112RNF2_27304074_Chip-Seq_NSC_Mouse0.99382574
113P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99310081
114BCAT_22108803_ChIP-Seq_LS180_Human0.97468017
115* SMAD3_21741376_ChIP-Seq_ESCs_Human0.97319259
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95998870
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95941908
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95941908
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95600187
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95570469
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95022797
122EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94308123
123RUNX2_22187159_ChIP-Seq_PCA_Human0.94234309
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92670052
125SMAD4_21741376_ChIP-Seq_EPCs_Human0.89725368
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88935314
127* TET1_21490601_ChIP-Seq_MESCs_Mouse0.88143191
128TP53_20018659_ChIP-ChIP_R1E_Mouse0.86587363
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86367086
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85930017
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.85872097
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.84752260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.89811731
2MP0001968_abnormal_touch/_nociception4.70033610
3MP0002736_abnormal_nociception_after4.03667542
4MP0009046_muscle_twitch3.79531221
5MP0002735_abnormal_chemical_nociception3.69760683
6MP0003880_abnormal_central_pattern3.63530179
7* MP0003635_abnormal_synaptic_transmissio3.62595042
8MP0004270_analgesia3.58731427
9MP0002734_abnormal_mechanical_nocicepti3.26563214
10MP0009745_abnormal_behavioral_response2.95429052
11MP0010386_abnormal_urinary_bladder2.91688936
12* MP0002272_abnormal_nervous_system2.82834799
13MP0002064_seizures2.81407455
14MP0002733_abnormal_thermal_nociception2.72343347
15MP0002063_abnormal_learning/memory/cond2.66656794
16MP0006035_abnormal_mitochondrial_morpho2.64517734
17MP0005423_abnormal_somatic_nervous2.62076032
18MP0002067_abnormal_sensory_capabilities2.46464811
19MP0001970_abnormal_pain_threshold2.40248283
20MP0002572_abnormal_emotion/affect_behav2.37297529
21MP0008569_lethality_at_weaning2.35585174
22MP0002184_abnormal_innervation2.16864636
23MP0004145_abnormal_muscle_electrophysio2.14890382
24MP0001440_abnormal_grooming_behavior2.08596710
25MP0001486_abnormal_startle_reflex2.07133824
26MP0008875_abnormal_xenobiotic_pharmacok1.89091816
27MP0000751_myopathy1.86381033
28MP0001501_abnormal_sleep_pattern1.85777621
29MP0004858_abnormal_nervous_system1.84470795
30MP0004215_abnormal_myocardial_fiber1.79094897
31MP0006276_abnormal_autonomic_nervous1.78976806
32MP0002837_dystrophic_cardiac_calcinosis1.72185074
33MP0005386_behavior/neurological_phenoty1.67915060
34MP0004924_abnormal_behavior1.67915060
35MP0003329_amyloid_beta_deposits1.59991437
36MP0002557_abnormal_social/conspecific_i1.56742738
37MP0000955_abnormal_spinal_cord1.54710861
38MP0004811_abnormal_neuron_physiology1.53886985
39MP0000778_abnormal_nervous_system1.52943366
40MP0004142_abnormal_muscle_tone1.43315354
41MP0001986_abnormal_taste_sensitivity1.39909812
42MP0008877_abnormal_DNA_methylation1.36412342
43MP0001984_abnormal_olfaction1.35813417
44* MP0002066_abnormal_motor_capabilities/c1.35662394
45MP0004484_altered_response_of1.33309092
46MP0000566_synostosis1.31898417
47MP0002909_abnormal_adrenal_gland1.29836853
48MP0002822_catalepsy1.29073221
49* MP0002882_abnormal_neuron_morphology1.28993293
50MP0003137_abnormal_impulse_conducting1.25018307
51MP0003879_abnormal_hair_cell1.22278778
52MP0004085_abnormal_heartbeat1.22242184
53MP0003633_abnormal_nervous_system1.20778291
54MP0004084_abnormal_cardiac_muscle1.20751985
55MP0004036_abnormal_muscle_relaxation1.20419899
56MP0001485_abnormal_pinna_reflex1.17850553
57MP0003646_muscle_fatigue1.12957164
58MP0006072_abnormal_retinal_apoptosis1.12684385
59MP0002102_abnormal_ear_morphology1.12271342
60MP0009780_abnormal_chondrocyte_physiolo1.11222841
61MP0004147_increased_porphyrin_level1.10537044
62MP0005623_abnormal_meninges_morphology1.09207958
63MP0000534_abnormal_ureter_morphology1.07838369
64MP0000013_abnormal_adipose_tissue1.07781397
65MP0003631_nervous_system_phenotype1.07566804
66MP0000569_abnormal_digit_pigmentation1.07426261
67MP0005499_abnormal_olfactory_system1.06551527
68MP0005394_taste/olfaction_phenotype1.06551527
69MP0003890_abnormal_embryonic-extraembry1.04787537
70MP0004742_abnormal_vestibular_system1.04092612
71MP0004043_abnormal_pH_regulation1.01877017
72MP0004885_abnormal_endolymph1.01506215
73MP0005410_abnormal_fertilization1.01151716
74MP0003632_abnormal_nervous_system0.95056241
75MP0001502_abnormal_circadian_rhythm0.94401232
76MP0001188_hyperpigmentation0.94163677
77MP0003122_maternal_imprinting0.93079037
78MP0002229_neurodegeneration0.92194444
79* MP0002152_abnormal_brain_morphology0.92062947
80MP0002972_abnormal_cardiac_muscle0.88738875
81MP0003121_genomic_imprinting0.87508647
82MP0000747_muscle_weakness0.86627834
83MP0002234_abnormal_pharynx_morphology0.85701375
84MP0003283_abnormal_digestive_organ0.85697426
85MP0008789_abnormal_olfactory_epithelium0.85378040
86MP0005620_abnormal_muscle_contractility0.85104526
87MP0008872_abnormal_physiological_respon0.84860547
88MP0000749_muscle_degeneration0.84320823
89MP0002160_abnormal_reproductive_system0.84133199
90MP0005187_abnormal_penis_morphology0.81765213
91MP0008874_decreased_physiological_sensi0.81201983
92MP0005551_abnormal_eye_electrophysiolog0.80834052
93MP0004233_abnormal_muscle_weight0.80574962
94MP0008961_abnormal_basal_metabolism0.77210869
95MP0001299_abnormal_eye_distance/0.76148289
96MP0003634_abnormal_glial_cell0.75083218
97MP0002752_abnormal_somatic_nervous0.75003568
98MP0000920_abnormal_myelination0.74838274
99MP0005253_abnormal_eye_physiology0.73823401
100MP0001177_atelectasis0.72981910
101MP0008775_abnormal_heart_ventricle0.72062398
102MP0003698_abnormal_male_reproductive0.69953993
103MP0005646_abnormal_pituitary_gland0.69649643
104MP0003119_abnormal_digestive_system0.69257220
105MP0000358_abnormal_cell_content/0.69039847
106MP0003011_delayed_dark_adaptation0.68331395
107MP0003861_abnormal_nervous_system0.67929788
108MP0000026_abnormal_inner_ear0.67902765
109MP0004510_myositis0.67116171
110MP0002277_abnormal_respiratory_mucosa0.66608922
111MP0002069_abnormal_eating/drinking_beha0.66117992
112MP0002638_abnormal_pupillary_reflex0.64413756
113MP0004130_abnormal_muscle_cell0.64077033
114MP0000604_amyloidosis0.63904813
115MP0005535_abnormal_body_temperature0.63265831
116MP0003718_maternal_effect0.63024140
117MP0006138_congestive_heart_failure0.62177267
118MP0001963_abnormal_hearing_physiology0.61880940
119MP0003690_abnormal_glial_cell0.60995290
120MP0005167_abnormal_blood-brain_barrier0.59752201
121MP0001529_abnormal_vocalization0.59665198
122MP0004087_abnormal_muscle_fiber0.59461982
123MP0006292_abnormal_olfactory_placode0.59381347
124MP0001905_abnormal_dopamine_level0.56081910
125MP0003183_abnormal_peptide_metabolism0.55893709
126MP0005595_abnormal_vascular_smooth0.54349040
127MP0001943_abnormal_respiration0.53674727
128MP0002332_abnormal_exercise_endurance0.53340997
129MP0003045_fibrosis0.52811125
130MP0003787_abnormal_imprinting0.52638769
131MP0002106_abnormal_muscle_physiology0.51750385
132MP0005171_absent_coat_pigmentation0.51542279

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.48558532
2Myokymia (HP:0002411)6.20733088
3Action tremor (HP:0002345)5.66249734
4Focal seizures (HP:0007359)5.49025869
5Atonic seizures (HP:0010819)5.48779964
6Progressive cerebellar ataxia (HP:0002073)5.32302421
7Visual hallucinations (HP:0002367)4.88312094
8Febrile seizures (HP:0002373)4.86029833
9Epileptic encephalopathy (HP:0200134)4.18882382
10Absence seizures (HP:0002121)4.16087386
11Gaze-evoked nystagmus (HP:0000640)4.11200476
12Dysdiadochokinesis (HP:0002075)3.73542521
13Broad-based gait (HP:0002136)3.70194661
14Dialeptic seizures (HP:0011146)3.66353767
15Generalized tonic-clonic seizures (HP:0002069)3.59101436
16Scanning speech (HP:0002168)3.57292263
17Dysmetric saccades (HP:0000641)3.45167132
18Truncal ataxia (HP:0002078)3.33578593
19Pheochromocytoma (HP:0002666)3.31341203
20Termporal pattern (HP:0011008)3.18144515
21Insidious onset (HP:0003587)3.18144515
22Impaired smooth pursuit (HP:0007772)3.10789830
23Poor eye contact (HP:0000817)3.08635371
24Hemiplegia (HP:0002301)3.02754471
25Myotonia (HP:0002486)3.02095771
26Degeneration of the lateral corticospinal tracts (HP:0002314)3.00828019
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.00828019
28Ventricular fibrillation (HP:0001663)3.00460813
29Dysmetria (HP:0001310)2.97241361
30Neuroendocrine neoplasm (HP:0100634)2.95967081
31Ankle clonus (HP:0011448)2.86708239
32Abnormal social behavior (HP:0012433)2.86500211
33Impaired social interactions (HP:0000735)2.86500211
34Supranuclear gaze palsy (HP:0000605)2.81992745
35Depression (HP:0000716)2.80188354
36Postural tremor (HP:0002174)2.77588935
37Abnormality of ocular smooth pursuit (HP:0000617)2.75053026
38Intention tremor (HP:0002080)2.71573478
39Abnormality of binocular vision (HP:0011514)2.69985132
40Diplopia (HP:0000651)2.69985132
41Hemiparesis (HP:0001269)2.68118690
42Status epilepticus (HP:0002133)2.64892212
43Impaired vibration sensation in the lower limbs (HP:0002166)2.63256731
44Abnormality of the lower motor neuron (HP:0002366)2.62114614
45Genetic anticipation (HP:0003743)2.62110063
46Acute necrotizing encephalopathy (HP:0006965)2.56514315
47Anxiety (HP:0000739)2.54245204
48Abnormality of pain sensation (HP:0010832)2.52808104
49Impaired pain sensation (HP:0007328)2.52808104
50Urinary bladder sphincter dysfunction (HP:0002839)2.52457542
51Abnormality of the corticospinal tract (HP:0002492)2.50764566
52Urinary urgency (HP:0000012)2.49743854
53Agitation (HP:0000713)2.47336767
54Abnormal eating behavior (HP:0100738)2.47202149
55Annular pancreas (HP:0001734)2.43683143
56Hyperventilation (HP:0002883)2.40741264
57Amblyopia (HP:0000646)2.40035234
58Bundle branch block (HP:0011710)2.38557393
59Ulnar claw (HP:0001178)2.36470211
60Mutism (HP:0002300)2.33217872
61Horizontal nystagmus (HP:0000666)2.31464565
62Progressive macrocephaly (HP:0004481)2.29604771
63Sudden death (HP:0001699)2.25670097
64Progressive inability to walk (HP:0002505)2.25474975
65Spastic gait (HP:0002064)2.24003874
66Lower limb asymmetry (HP:0100559)2.20578070
67Abnormal mitochondria in muscle tissue (HP:0008316)2.20255965
68Acute encephalopathy (HP:0006846)2.17503216
69Prolonged QT interval (HP:0001657)2.14528276
70Postural instability (HP:0002172)2.14048651
71Fetal akinesia sequence (HP:0001989)2.09974097
72Torticollis (HP:0000473)2.09570982
73Neoplasm of the peripheral nervous system (HP:0100007)2.05388339
74Gait ataxia (HP:0002066)2.05275030
75Tetraplegia (HP:0002445)2.02817208
76Exercise-induced myalgia (HP:0003738)2.02654300
77Drooling (HP:0002307)1.98685525
78Excessive salivation (HP:0003781)1.98685525
79Retinal dysplasia (HP:0007973)1.98100753
80Papilledema (HP:0001085)1.97488474
81Abnormality of saccadic eye movements (HP:0000570)1.96148866
82Epileptiform EEG discharges (HP:0011182)1.95918052
83EEG with generalized epileptiform discharges (HP:0011198)1.95061205
84Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94876399
85Failure to thrive in infancy (HP:0001531)1.94855954
86Syncope (HP:0001279)1.94263852
87Stereotypic behavior (HP:0000733)1.93905262
88Focal dystonia (HP:0004373)1.93890283
89Amyotrophic lateral sclerosis (HP:0007354)1.91797021
90Hypoventilation (HP:0002791)1.90923186
91Neuronal loss in central nervous system (HP:0002529)1.90452991
92Slow progression (HP:0003677)1.89537255
93Psychosis (HP:0000709)1.89336048
94Morphological abnormality of the pyramidal tract (HP:0002062)1.89315260
95Pointed chin (HP:0000307)1.88953413
96Limb dystonia (HP:0002451)1.87663154
97Abnormal EKG (HP:0003115)1.87411629
98Gait imbalance (HP:0002141)1.86898764
99Hypsarrhythmia (HP:0002521)1.86811772
100Genital tract atresia (HP:0001827)1.86122134
101Aqueductal stenosis (HP:0002410)1.84749057
102Papillary thyroid carcinoma (HP:0002895)1.82740378
103Incomplete penetrance (HP:0003829)1.82416691
104Lower limb muscle weakness (HP:0007340)1.81241435
105Abnormality of the vocal cords (HP:0008777)1.80117283
106Short tibia (HP:0005736)1.79397505
107Limb ataxia (HP:0002070)1.79030632
108Medial flaring of the eyebrow (HP:0010747)1.78023099
109Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77017273
110Hypoplasia of the brainstem (HP:0002365)1.77017273
111Impaired vibratory sensation (HP:0002495)1.76627678
112Bradykinesia (HP:0002067)1.76214993
113Cerebellar atrophy (HP:0001272)1.75370712
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.74982324
115Esotropia (HP:0000565)1.74975531
116Congenital primary aphakia (HP:0007707)1.71035532
117Epidermoid cyst (HP:0200040)1.69233658
118Aplasia involving bones of the upper limbs (HP:0009823)1.68322067
119Aplasia of the phalanges of the hand (HP:0009802)1.68322067
120Aplasia involving bones of the extremities (HP:0009825)1.68322067
121Mitochondrial inheritance (HP:0001427)1.66533917
122Cutaneous finger syndactyly (HP:0010554)1.64685076
123Autoamputation (HP:0001218)1.64543684
124Hyperlipoproteinemia (HP:0010980)1.63600492
125Vaginal atresia (HP:0000148)1.61243963
126Increased serum pyruvate (HP:0003542)1.60197095
127Intellectual disability, mild (HP:0001256)1.56382087
128Dysarthria (HP:0001260)1.56236542
129Abnormality of the phalanges of the 2nd finger (HP:0009541)1.54407018
130Optic nerve hypoplasia (HP:0000609)1.54243268
131Cerebral edema (HP:0002181)1.48886988
132Preaxial foot polydactyly (HP:0001841)1.48110933
133Type II lissencephaly (HP:0007260)1.47177629
134Degeneration of anterior horn cells (HP:0002398)1.43155351
135Abnormality of the anterior horn cell (HP:0006802)1.43155351
136Nephrogenic diabetes insipidus (HP:0009806)1.43148088
137Supernumerary spleens (HP:0009799)1.42876211
138Toxemia of pregnancy (HP:0100603)1.41442198
139Cutaneous syndactyly (HP:0012725)1.41147493
140Abnormality of the labia minora (HP:0012880)1.35879743
141Athetosis (HP:0002305)1.32533246
142Inability to walk (HP:0002540)1.32285904
143Choroideremia (HP:0001139)1.30932367
144Abnormality of glycolysis (HP:0004366)1.30414949
145Bifid tongue (HP:0010297)1.27165827
146Increased CSF lactate (HP:0002490)1.26678989
147Volvulus (HP:0002580)1.26494597
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.25581568
149Polyphagia (HP:0002591)1.25072470
150Increased hepatocellular lipid droplets (HP:0006565)1.24949794
151Anterior segment dysgenesis (HP:0007700)1.24357736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.89934547
2NTRK33.64666926
3MAP3K43.06392978
4MINK12.82710205
5MARK12.69465435
6TTK2.64129534
7CAMKK22.63237474
8RIPK42.53463616
9MAP2K72.38201277
10DAPK22.34517971
11MAP2K42.24466890
12KSR22.16650513
13TAF12.14320490
14PAK62.09531674
15NTRK12.02618879
16EPHA42.00037677
17CASK1.92529210
18CSNK1G31.91654037
19CAMKK11.91398560
20RIPK11.89786017
21CSNK1A1L1.85140339
22NTRK21.83181269
23GRK51.74962372
24MAP3K121.69950844
25CSNK1G11.69458992
26PHKG21.68708346
27PHKG11.68708346
28BRAF1.62897910
29INSRR1.49943017
30WNK11.49268413
31LMTK21.42908040
32RET1.42207125
33MAPK131.36565334
34CDK51.32993289
35MAP3K131.32625913
36BMPR1B1.30771938
37STK381.29581386
38PRKCG1.28861220
39SGK2231.27505884
40SGK4941.27505884
41PLK21.27423975
42UHMK11.23074287
43MAP3K21.20177681
44LATS21.20102736
45SGK21.18616477
46PRKD31.16165053
47TRIM281.12652921
48SIK21.10064988
49KSR11.09162381
50CDK191.07865593
51PNCK1.06844291
52ARAF1.05772156
53DAPK11.04360748
54RAF11.00873934
55* PRKG10.98745769
56CAMK2A0.96367929
57CDK140.96242923
58FRK0.96102447
59SGK30.94573424
60PRKCH0.92061841
61PINK10.90821087
62TYRO30.90317717
63PTK2B0.90300262
64NEK10.87349779
65PRPF4B0.85842902
66STK110.84954666
67CDK180.84433055
68BCR0.84374001
69CDK150.83402027
70ACVR1B0.82862046
71PTK60.82357420
72WEE10.80279023
73CDK30.78444817
74CAMK10.77987715
75CAMK2D0.76666419
76TESK10.75498450
77OXSR10.75134601
78CHEK20.74095623
79FER0.72683122
80FES0.71155187
81CDC42BPA0.70949390
82CDK11A0.70427949
83CSNK1E0.69984152
84TNIK0.68152988
85PRKG20.67809997
86WNK30.67742308
87MOS0.67537252
88PAK30.67441953
89ROCK20.66917247
90LIMK10.66604535
91CAMK2G0.66311318
92CAMK2B0.65543777
93PDK10.64660742
94CSNK1D0.64015685
95MAPK120.62862558
96CAMK40.62254097
97PRKCE0.61562700
98DYRK1A0.60983104
99PKN10.60459299
100RPS6KA20.59660909
101PRKDC0.59049072
102PDPK10.58699275
103CSNK1A10.58061296
104PLK10.57601987
105CCNB10.57569631
106SGK10.57293550
107ADRBK20.56573591
108CSNK1G20.55893197
109PKN20.54905797
110TIE10.54493799
111PLK40.54019742
112* PRKCA0.53537144
113ALK0.53314144
114PDK40.53039582
115PDK30.53039582
116ZAK0.52071175
117MAP3K10.52001068
118MAP2K10.51961556
119PRKCZ0.50244656
120ERBB20.50034320
121FGFR20.49914025
122RPS6KA30.49698622
123AKT30.49306767
124FYN0.47861643
125STK390.47824694
126WNK40.46612390
127MARK20.45868153
128TSSK60.45741697
129PRKACA0.45628939
130SCYL20.44539888
131OBSCN0.43452390
132ADRBK10.43027169
133DMPK0.42547207
134MARK30.40938416
135PRKCB0.40777159
136BMPR20.39986423
137LATS10.38637110
138AURKA0.38079677
139MYLK0.37703797
140MAPK100.36865863
141EPHB20.35588143
142ROCK10.34932102
143BUB10.34846393
144CAMK1G0.34435890
145MAP4K20.34159738
146NEK60.33813711
147ERBB40.32648324
148NUAK10.32197479

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.60044377
2Synaptic vesicle cycle_Homo sapiens_hsa047213.06270317
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66419950
4Glutamatergic synapse_Homo sapiens_hsa047242.65341895
5Long-term potentiation_Homo sapiens_hsa047202.56816103
6GABAergic synapse_Homo sapiens_hsa047272.51963056
7Circadian entrainment_Homo sapiens_hsa047132.51598565
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39965297
9Morphine addiction_Homo sapiens_hsa050322.35031611
10Taste transduction_Homo sapiens_hsa047422.21597782
11Olfactory transduction_Homo sapiens_hsa047402.13642541
12Long-term depression_Homo sapiens_hsa047302.10495730
13Salivary secretion_Homo sapiens_hsa049702.08616160
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02811607
15Dopaminergic synapse_Homo sapiens_hsa047281.96013089
16Amphetamine addiction_Homo sapiens_hsa050311.92544610
17Insulin secretion_Homo sapiens_hsa049111.88329058
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.82067716
19Gastric acid secretion_Homo sapiens_hsa049711.76713279
20Cardiac muscle contraction_Homo sapiens_hsa042601.73914915
21Cholinergic synapse_Homo sapiens_hsa047251.72320511
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68655271
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66627339
24Oxytocin signaling pathway_Homo sapiens_hsa049211.55646046
25Serotonergic synapse_Homo sapiens_hsa047261.52725221
26Calcium signaling pathway_Homo sapiens_hsa040201.50954749
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47115381
28Renin secretion_Homo sapiens_hsa049241.46550332
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40688304
30Gap junction_Homo sapiens_hsa045401.39582901
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31063839
32GnRH signaling pathway_Homo sapiens_hsa049121.30405258
33Type II diabetes mellitus_Homo sapiens_hsa049301.27280518
34Collecting duct acid secretion_Homo sapiens_hsa049661.20352279
35Estrogen signaling pathway_Homo sapiens_hsa049151.17770342
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17054542
37cAMP signaling pathway_Homo sapiens_hsa040241.15587767
38Cocaine addiction_Homo sapiens_hsa050301.08790480
39Dilated cardiomyopathy_Homo sapiens_hsa054141.06584163
40Pancreatic secretion_Homo sapiens_hsa049721.04815939
41Pentose phosphate pathway_Homo sapiens_hsa000301.03716031
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.99445634
43Thyroid hormone synthesis_Homo sapiens_hsa049180.98288903
44Axon guidance_Homo sapiens_hsa043600.96818893
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96091814
46Melanogenesis_Homo sapiens_hsa049160.92326984
47Dorso-ventral axis formation_Homo sapiens_hsa043200.92048213
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88316618
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87539567
50Glioma_Homo sapiens_hsa052140.87354249
51Oocyte meiosis_Homo sapiens_hsa041140.87203149
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87153310
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.85420609
54Alzheimers disease_Homo sapiens_hsa050100.83424581
55ErbB signaling pathway_Homo sapiens_hsa040120.81051063
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80609577
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80225006
58Fructose and mannose metabolism_Homo sapiens_hsa000510.80212624
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79064907
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78930220
61Protein export_Homo sapiens_hsa030600.76418295
62Basal transcription factors_Homo sapiens_hsa030220.75778954
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71843653
64Glycerolipid metabolism_Homo sapiens_hsa005610.69399127
65Oxidative phosphorylation_Homo sapiens_hsa001900.69117193
66Bile secretion_Homo sapiens_hsa049760.68762653
67Renin-angiotensin system_Homo sapiens_hsa046140.68386132
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68035172
69Vibrio cholerae infection_Homo sapiens_hsa051100.66473495
70Phototransduction_Homo sapiens_hsa047440.65552611
71Choline metabolism in cancer_Homo sapiens_hsa052310.64940026
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64279002
73MAPK signaling pathway_Homo sapiens_hsa040100.62275621
74Parkinsons disease_Homo sapiens_hsa050120.61344191
75VEGF signaling pathway_Homo sapiens_hsa043700.59599568
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.59084651
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58986173
78Pyruvate metabolism_Homo sapiens_hsa006200.58079044
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56960560
80Rap1 signaling pathway_Homo sapiens_hsa040150.56316138
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55547302
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53699374
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51796307
84mTOR signaling pathway_Homo sapiens_hsa041500.51792858
85Glucagon signaling pathway_Homo sapiens_hsa049220.50870579
86Inositol phosphate metabolism_Homo sapiens_hsa005620.49451210
87Circadian rhythm_Homo sapiens_hsa047100.48534913
88Insulin signaling pathway_Homo sapiens_hsa049100.47698879
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44492049
90Ras signaling pathway_Homo sapiens_hsa040140.43551695
91Butanoate metabolism_Homo sapiens_hsa006500.43399314
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.43038702
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41808488
94Endometrial cancer_Homo sapiens_hsa052130.40475313
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40465666
96Hippo signaling pathway_Homo sapiens_hsa043900.40040909
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39763985
98Huntingtons disease_Homo sapiens_hsa050160.39207520
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38841793
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38815036
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38176121
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37979513
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37501930
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.36739898
105Endocytosis_Homo sapiens_hsa041440.35659203
106Renal cell carcinoma_Homo sapiens_hsa052110.34811113
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.34680050
108Nitrogen metabolism_Homo sapiens_hsa009100.33069700
109Tight junction_Homo sapiens_hsa045300.31676713
110Mineral absorption_Homo sapiens_hsa049780.30134283
111African trypanosomiasis_Homo sapiens_hsa051430.28545633
112Hedgehog signaling pathway_Homo sapiens_hsa043400.28416746
113Alcoholism_Homo sapiens_hsa050340.28195417
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26358133
115Wnt signaling pathway_Homo sapiens_hsa043100.26097631
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25953136
117TGF-beta signaling pathway_Homo sapiens_hsa043500.25051815
118Cell cycle_Homo sapiens_hsa041100.24796295
119Propanoate metabolism_Homo sapiens_hsa006400.22774542
120ABC transporters_Homo sapiens_hsa020100.20405409
121Fatty acid biosynthesis_Homo sapiens_hsa000610.18382749
122Protein digestion and absorption_Homo sapiens_hsa049740.14452028
123Fatty acid elongation_Homo sapiens_hsa000620.12508191
124Fanconi anemia pathway_Homo sapiens_hsa034600.08766010

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »