TRPC5OS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)8.57077920
2regulation of oxidative stress-induced neuron death (GO:1903203)8.26046913
3regulation of oxidative phosphorylation (GO:0002082)7.19826947
4relaxation of smooth muscle (GO:0044557)7.17429124
5binding of sperm to zona pellucida (GO:0007339)7.10738473
6nucleosome disassembly (GO:0006337)6.89759219
7protein-DNA complex disassembly (GO:0032986)6.89759219
8male sex determination (GO:0030238)6.87295310
9gonadal mesoderm development (GO:0007506)6.86816452
10G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.78008749
11cilium or flagellum-dependent cell motility (GO:0001539)6.65920554
12potassium ion export (GO:0071435)6.52720662
13Leydig cell differentiation (GO:0033327)6.49954137
14negative regulation of hydrogen peroxide-induced cell death (GO:1903206)6.46503303
15glutamate receptor signaling pathway (GO:0007215)6.17930189
16synapsis (GO:0007129)6.15868207
17piRNA metabolic process (GO:0034587)5.99640008
18negative regulation of response to reactive oxygen species (GO:1901032)5.89237884
19organic cation transport (GO:0015695)5.87389172
20regulation of hydrogen peroxide-induced cell death (GO:1903205)5.86455007
21polyamine biosynthetic process (GO:0006596)5.71817962
22cGMP-mediated signaling (GO:0019934)5.64771029
23activation of protein kinase B activity (GO:0032148)5.63689930
24sperm-egg recognition (GO:0035036)5.55205806
25ionotropic glutamate receptor signaling pathway (GO:0035235)5.45956879
26epithelial cilium movement (GO:0003351)5.43173190
27cilium movement (GO:0003341)5.40563218
28synaptic transmission, glutamatergic (GO:0035249)5.36579605
29androgen biosynthetic process (GO:0006702)5.29034134
30cell-cell recognition (GO:0009988)5.03657723
31plasma membrane fusion (GO:0045026)4.90407009
32TOR signaling (GO:0031929)4.87447183
33regulation of dopamine secretion (GO:0014059)4.86914686
34germ cell development (GO:0007281)4.84782930
35regulation of autophagic vacuole assembly (GO:2000785)4.84470325
36protein polymerization (GO:0051258)4.78425070
37reproduction (GO:0000003)4.77322097
38glutamine family amino acid catabolic process (GO:0009065)4.75775145
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.74541058
40glycogen metabolic process (GO:0005977)4.73872442
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.70292410
42regulation of axon regeneration (GO:0048679)4.69594220
43regulation of neuron projection regeneration (GO:0070570)4.69594220
44glucan metabolic process (GO:0044042)4.69431731
45cellular glucan metabolic process (GO:0006073)4.69431731
46male meiosis (GO:0007140)4.67714286
47negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.63830743
48regulation of cellular respiration (GO:0043457)4.61672410
49negative regulation of inclusion body assembly (GO:0090084)4.61144663
50opioid receptor signaling pathway (GO:0038003)4.53250333
51regulation of acrosome reaction (GO:0060046)4.52979823
52response to acidic pH (GO:0010447)4.50422013
53oogenesis (GO:0048477)4.48104508
54positive regulation of glycolytic process (GO:0045821)4.47151220
55regulation of glutamate receptor signaling pathway (GO:1900449)4.45857233
56tongue development (GO:0043586)4.37317471
57histone exchange (GO:0043486)4.34566544
58membrane depolarization during action potential (GO:0086010)4.32418275
59regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.29614810
60sex determination (GO:0007530)4.27544708
61mRNA splice site selection (GO:0006376)4.23487325
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.22221311
63negative regulation of metanephros development (GO:0072217)4.20376438
64mitochondrion degradation (GO:0000422)4.20149128
65regulation of synaptic transmission, dopaminergic (GO:0032225)4.19763804
66calcium ion import (GO:0070509)4.18238251
67ventricular system development (GO:0021591)4.16667989
68membrane repolarization during action potential (GO:0086011)4.16492474
69regulation of vacuole organization (GO:0044088)4.08246156
70acrosome assembly (GO:0001675)4.07515637
71chromosome organization involved in meiosis (GO:0070192)4.06802906
72cellular response to toxic substance (GO:0097237)4.01179740
73dicarboxylic acid biosynthetic process (GO:0043650)4.00182804
74negative regulation of hormone metabolic process (GO:0032351)3.99945620
75negative regulation of hormone biosynthetic process (GO:0032353)3.99945620
76neuron-neuron synaptic transmission (GO:0007270)3.99757507
77cellular biogenic amine biosynthetic process (GO:0042401)3.99090520
78negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)3.98313357
79aspartate family amino acid catabolic process (GO:0009068)3.94730853
80amine biosynthetic process (GO:0009309)3.93869601
81negative regulation of adenylate cyclase activity (GO:0007194)3.91567949
82axonemal dynein complex assembly (GO:0070286)3.91308310
83positive regulation of synapse maturation (GO:0090129)3.91170370
84positive regulation of amine transport (GO:0051954)3.85514262
85coenzyme catabolic process (GO:0009109)3.84615082
86cellular process involved in reproduction in multicellular organism (GO:0022412)3.83440637
87diacylglycerol metabolic process (GO:0046339)3.82288889
88negative regulation of cyclase activity (GO:0031280)3.80493949
89negative regulation of JNK cascade (GO:0046329)3.79723141
90negative regulation of smooth muscle contraction (GO:0045986)3.78387560
91vocalization behavior (GO:0071625)3.77092087
92neuron cell-cell adhesion (GO:0007158)3.75299315
93DNA methylation involved in gamete generation (GO:0043046)3.75129513
94calcium ion-dependent exocytosis (GO:0017156)3.73206749
95sperm motility (GO:0030317)3.72999777
96regulation of phosphatase activity (GO:0010921)3.72473306
97phosphatidylethanolamine biosynthetic process (GO:0006646)3.71397786
98meiotic nuclear division (GO:0007126)3.69296009
99neuron recognition (GO:0008038)3.66540210
100positive regulation of meiosis (GO:0045836)3.66298007
101synaptonemal complex organization (GO:0070193)3.63050308
102tryptophan catabolic process (GO:0006569)3.60456950
103indole-containing compound catabolic process (GO:0042436)3.60456950
104indolalkylamine catabolic process (GO:0046218)3.60456950
105fusion of sperm to egg plasma membrane (GO:0007342)3.60448213
106spermatid development (GO:0007286)3.58995353
107regulation of meiosis (GO:0040020)3.58153834
108protein localization to cilium (GO:0061512)3.57301427
109positive regulation of receptor recycling (GO:0001921)3.56836084
110membrane repolarization (GO:0086009)3.54679343
111negative regulation of lyase activity (GO:0051350)3.54601756
112histone H2B ubiquitination (GO:0033523)3.50714296
113polyamine metabolic process (GO:0006595)3.47989154
114oligosaccharide biosynthetic process (GO:0009312)3.47721818
115positive regulation of meiotic cell cycle (GO:0051446)3.47527756
116sex differentiation (GO:0007548)3.44524934
117regulation of Rac GTPase activity (GO:0032314)3.43209809
118axonal fasciculation (GO:0007413)3.42697631
119cellular sodium ion homeostasis (GO:0006883)3.40803921
120phosphatidylethanolamine metabolic process (GO:0046337)3.40585745
121regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.39545275
122vitamin transmembrane transport (GO:0035461)3.37342562
123microtubule depolymerization (GO:0007019)3.36751843
124cellular polysaccharide metabolic process (GO:0044264)3.35725850
125histone H3-K4 trimethylation (GO:0080182)3.34303688
126gamma-aminobutyric acid transport (GO:0015812)3.32150271
127DNA double-strand break processing (GO:0000729)3.31805369
128positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.31112659
129negative regulation of cAMP biosynthetic process (GO:0030818)3.30792670
130negative regulation of stress-activated MAPK cascade (GO:0032873)3.30400525
131negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)3.30400525
132regulation of calcium ion-dependent exocytosis (GO:0017158)3.30382228
133cell wall macromolecule catabolic process (GO:0016998)3.27663484
134cell wall macromolecule metabolic process (GO:0044036)3.27663484
135transmission of nerve impulse (GO:0019226)3.27399382
136dicarboxylic acid catabolic process (GO:0043649)3.27214276
137gamma-aminobutyric acid signaling pathway (GO:0007214)3.26097008
138synaptonemal complex assembly (GO:0007130)3.25744755
139long-term memory (GO:0007616)3.25583386
140central nervous system projection neuron axonogenesis (GO:0021952)3.25033891
141negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)3.24386397
142positive regulation of male gonad development (GO:2000020)3.22186580
143regulation of synaptic vesicle transport (GO:1902803)3.22178170
144male meiosis I (GO:0007141)3.21735260
145regulation of synapse maturation (GO:0090128)3.20734675
146glutamate secretion (GO:0014047)3.20609143
147negative regulation of cAMP metabolic process (GO:0030815)3.13832834
148glutathione derivative metabolic process (GO:1901685)3.13019075
149glutathione derivative biosynthetic process (GO:1901687)3.13019075
150polysaccharide metabolic process (GO:0005976)3.11527471
151relaxation of muscle (GO:0090075)3.10465141
152regulation of synaptic transmission, glutamatergic (GO:0051966)3.10428793
153regulation of meiotic cell cycle (GO:0051445)3.09750222
154negative regulation of cyclic nucleotide metabolic process (GO:0030800)3.08460237
155single fertilization (GO:0007338)3.05555043
156activation of Rac GTPase activity (GO:0032863)3.05527882
157ephrin receptor signaling pathway (GO:0048013)3.02247571
158multicellular organism reproduction (GO:0032504)3.01862108
159meiotic cell cycle (GO:0051321)2.96690061
160left/right pattern formation (GO:0060972)2.94005706
161negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.93532138
162negative regulation of nucleotide biosynthetic process (GO:0030809)2.93532138
163fertilization (GO:0009566)2.92382972
164positive regulation of dendritic spine morphogenesis (GO:0061003)2.91808637
165presynaptic membrane assembly (GO:0097105)2.91801318
166regulation of meiosis I (GO:0060631)2.90303672
167glucocorticoid biosynthetic process (GO:0006704)2.88979772
168regulation of protein kinase A signaling (GO:0010738)2.86164696
169regulation of dendritic spine morphogenesis (GO:0061001)2.85648903
170central nervous system neuron axonogenesis (GO:0021955)2.84048237
171left/right axis specification (GO:0070986)2.80378307
172cranial nerve morphogenesis (GO:0021602)2.79488307
173presynaptic membrane organization (GO:0097090)2.78007237
174single strand break repair (GO:0000012)2.76627384
175serotonin receptor signaling pathway (GO:0007210)2.75530438
176response to redox state (GO:0051775)2.75490552
177positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.71599569
178lens fiber cell differentiation (GO:0070306)2.71137539
179motile cilium assembly (GO:0044458)2.68000778
180membrane depolarization (GO:0051899)2.67060143
181startle response (GO:0001964)2.62818569
182regulation of inclusion body assembly (GO:0090083)2.61471972
183positive regulation of synaptic transmission, dopaminergic (GO:0032226)11.4681769
184regulation of phosphoprotein phosphatase activity (GO:0043666)10.6532453
185positive regulation of catecholamine secretion (GO:0033605)10.3459024

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.80953540
2IGF1R_20145208_ChIP-Seq_DFB_Human5.09509240
3ESR1_20079471_ChIP-ChIP_T-47D_Human4.00860406
4GBX2_23144817_ChIP-Seq_PC3_Human3.51901823
5VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human3.08919112
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.02588615
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.66287249
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.54129790
9VDR_22108803_ChIP-Seq_LS180_Human2.49191400
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42484793
11ZNF274_21170338_ChIP-Seq_K562_Hela2.39192440
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34792267
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25055293
14DROSHA_22980978_ChIP-Seq_HELA_Human2.17542738
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06239685
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05765200
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04815398
18AHR_22903824_ChIP-Seq_MCF-7_Human2.02485866
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.02385179
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01844493
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.9831460
22BP1_19119308_ChIP-ChIP_Hs578T_Human10.2856303
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.97615033
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.95612994
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89330903
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.88572418
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87013257
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86757996
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85776863
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83391105
31SMAD4_21799915_ChIP-Seq_A2780_Human1.82693804
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82366622
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.80070176
34AR_21572438_ChIP-Seq_LNCaP_Human1.76758712
35TAF15_26573619_Chip-Seq_HEK293_Human1.75206604
36AR_21909140_ChIP-Seq_LNCAP_Human1.74238652
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73114527
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73114527
39FUS_26573619_Chip-Seq_HEK293_Human1.73024402
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71575306
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69252168
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.68724626
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66393931
44NANOG_20526341_ChIP-Seq_ESCs_Human1.66322701
45EWS_26573619_Chip-Seq_HEK293_Human1.65982260
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65711403
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62489334
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60014078
49STAT3_23295773_ChIP-Seq_U87_Human1.57888396
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56266298
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54894750
52REST_21632747_ChIP-Seq_MESCs_Mouse1.54676300
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54005941
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.52446313
55P300_19829295_ChIP-Seq_ESCs_Human1.49263486
56RNF2_27304074_Chip-Seq_NSC_Mouse1.49222818
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48540618
58CBP_20019798_ChIP-Seq_JUKART_Human1.47665884
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47665884
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.45695089
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.44405892
62OCT1_27270436_Chip-Seq_PROSTATE_Human1.44205333
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43209726
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43209726
65ER_23166858_ChIP-Seq_MCF-7_Human1.43087711
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41950806
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.41096677
68RAC3_21632823_ChIP-Seq_H3396_Human1.40089976
69WDR5_24793694_ChIP-Seq_LNCAP_Human1.40019936
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39861575
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39609261
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39391875
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38869348
74CTCF_27219007_Chip-Seq_Bcells_Human1.38740798
75LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38659168
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38649902
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37358017
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.36966760
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35754660
80ERA_21632823_ChIP-Seq_H3396_Human1.34557310
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.34072199
82TCF4_23295773_ChIP-Seq_U87_Human1.33318137
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.33287873
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.33090262
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32452760
86P53_22387025_ChIP-Seq_ESCs_Mouse1.32450288
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32205141
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31531165
89BCAT_22108803_ChIP-Seq_LS180_Human1.30347095
90AR_25329375_ChIP-Seq_VCAP_Human1.30139041
91OCT4_20526341_ChIP-Seq_ESCs_Human1.29936779
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.29581021
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28294444
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.28148358
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27979097
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27723723
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.27109024
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26762360
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.24485627
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24120824
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22335161
102SMC4_20622854_ChIP-Seq_HELA_Human1.19952627
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.19301979
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.17888545
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17327082
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16822498
107P300_18555785_Chip-Seq_ESCs_Mouse1.15670527
108TBL1_22424771_ChIP-Seq_293T_Human1.15400919
109SMAD3_21741376_ChIP-Seq_HESCs_Human1.13965321
110SOX2_18555785_Chip-Seq_ESCs_Mouse1.13663024
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12984408
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12200094
113OCT4_18555785_Chip-Seq_ESCs_Mouse1.11456715
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11086940
115RARB_27405468_Chip-Seq_BRAIN_Mouse1.10944001
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10491112
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10332706
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10240506
119MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10030142
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09308298
121RUNX2_22187159_ChIP-Seq_PCA_Human1.09007098
122ZNF263_19887448_ChIP-Seq_K562_Human1.08534749
123MYC_19829295_ChIP-Seq_ESCs_Human1.07801706
124YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07183275
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.06107827
126CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05777282
127GATA1_22025678_ChIP-Seq_K562_Human1.05626752
128ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05554227
129CTCF_18555785_Chip-Seq_ESCs_Mouse1.05219522
130ERG_20517297_ChIP-Seq_VCAP_Human1.04637233
131P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04479742
132TP53_18474530_ChIP-ChIP_U2OS_Human1.03816975
133NMYC_18555785_Chip-Seq_ESCs_Mouse1.02994002
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01900300
135KLF4_18555785_Chip-Seq_ESCs_Mouse1.01287644
136CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00981477
137PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00540529
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99646440
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98226163
140NANOG_19829295_ChIP-Seq_ESCs_Human0.98209265
141SOX2_19829295_ChIP-Seq_ESCs_Human0.98209265
142GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98086546
143SMAD4_21741376_ChIP-Seq_EPCs_Human0.98018437
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.95968436
145MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93725006
146VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92644349
147PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92341071
148RXR_22108803_ChIP-Seq_LS180_Human0.90032253
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89550755
150EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89373036
151HOXB7_26014856_ChIP-Seq_BT474_Human0.86566717
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86339663
153CTCF_20526341_ChIP-Seq_ESCs_Human0.85716878
154IRF8_21731497_ChIP-ChIP_J774_Mouse0.85677691
155E2F1_17053090_ChIP-ChIP_MCF-7_Human0.84779056
156SPI1_20517297_ChIP-Seq_HL60_Human0.84171722
157ELF5_23300383_ChIP-Seq_T47D_Human0.83533496
158RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81566848
159P300_27268052_Chip-Seq_Bcells_Human0.81038480
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80471449
161PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79275961
162ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79037186
163GF1B_26923725_Chip-Seq_HPCs_Mouse0.79003174
164P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.78821786
165EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76632399
166TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75967109
167RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75719944
168ESET_19884257_ChIP-Seq_ESCs_Mouse0.75244057
169AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74269827
170RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.73289174
171IRF1_19129219_ChIP-ChIP_H3396_Human0.72583847
172PHF8_20622854_ChIP-Seq_HELA_Human0.72344818
173TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71434796
174PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70986254
175FOXH1_21741376_ChIP-Seq_ESCs_Human0.70140795
176FOXH1_21741376_ChIP-Seq_EPCs_Human0.68978984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH6.16787729
2MP0004859_abnormal_synaptic_plasticity5.56386520
3MP0008877_abnormal_DNA_methylation4.25440293
4MP0000537_abnormal_urethra_morphology4.21696062
5MP0003123_paternal_imprinting3.99326383
6MP0002160_abnormal_reproductive_system3.93001164
7MP0003787_abnormal_imprinting3.81890258
8MP0003880_abnormal_central_pattern3.81444362
9MP0001968_abnormal_touch/_nociception3.79290841
10MP0005360_urolithiasis3.69011160
11MP0005058_abnormal_lysosome_morphology3.41242895
12MP0002876_abnormal_thyroid_physiology3.19620747
13MP0002736_abnormal_nociception_after3.13467417
14MP0004270_analgesia3.02656807
15MP0002735_abnormal_chemical_nociception3.00864152
16MP0005410_abnormal_fertilization2.91445092
17MP0003635_abnormal_synaptic_transmissio2.90708045
18MP0003045_fibrosis2.84017989
19MP0009745_abnormal_behavioral_response2.77756136
20MP0002572_abnormal_emotion/affect_behav2.40191722
21MP0001440_abnormal_grooming_behavior2.38489949
22MP0001501_abnormal_sleep_pattern2.30371300
23MP0001905_abnormal_dopamine_level2.30212519
24MP0002734_abnormal_mechanical_nocicepti2.30042865
25MP0005647_abnormal_sex_gland2.26880378
26MP0002063_abnormal_learning/memory/cond2.16668298
27MP0005171_absent_coat_pigmentation2.11143812
28MP0002132_abnormal_respiratory_system2.11123997
29MP0002272_abnormal_nervous_system2.05094474
30MP0005389_reproductive_system_phenotype2.04889074
31MP0003136_yellow_coat_color2.04657803
32MP0009046_muscle_twitch2.02050514
33MP0010386_abnormal_urinary_bladder1.98203736
34MP0010368_abnormal_lymphatic_system1.88266918
35MP0001664_abnormal_digestion1.88113152
36MP0004145_abnormal_muscle_electrophysio1.85639251
37MP0005394_taste/olfaction_phenotype1.84424274
38MP0005499_abnormal_olfactory_system1.84424274
39MP0001529_abnormal_vocalization1.79882477
40MP0002064_seizures1.79753884
41MP0001929_abnormal_gametogenesis1.79206116
42MP0003698_abnormal_male_reproductive1.77241002
43MP0003646_muscle_fatigue1.76469531
44MP0006292_abnormal_olfactory_placode1.75918591
45MP0003121_genomic_imprinting1.74012772
46MP0005187_abnormal_penis_morphology1.70960892
47MP0002102_abnormal_ear_morphology1.69099596
48MP0005623_abnormal_meninges_morphology1.65718988
49MP0000538_abnormal_urinary_bladder1.64450555
50MP0005451_abnormal_body_composition1.61225567
51MP0001188_hyperpigmentation1.60036116
52MP0001486_abnormal_startle_reflex1.55438846
53MP0006072_abnormal_retinal_apoptosis1.51929766
54MP0002067_abnormal_sensory_capabilities1.46166435
55MP0003718_maternal_effect1.42095126
56MP0003329_amyloid_beta_deposits1.41511361
57MP0000465_gastrointestinal_hemorrhage1.39299929
58MP0003936_abnormal_reproductive_system1.37645817
59MP0005646_abnormal_pituitary_gland1.33824204
60MP0003122_maternal_imprinting1.30359531
61MP0002653_abnormal_ependyma_morphology1.27608991
62MP0002733_abnormal_thermal_nociception1.26358196
63MP0002837_dystrophic_cardiac_calcinosis1.24771729
64MP0001849_ear_inflammation1.23994645
65MP0000778_abnormal_nervous_system1.19852659
66MP0003879_abnormal_hair_cell1.18176560
67MP0001970_abnormal_pain_threshold1.17108373
68MP0001919_abnormal_reproductive_system1.16188971
69MP0002210_abnormal_sex_determination1.15432262
70MP0006036_abnormal_mitochondrial_physio1.12266865
71MP0002161_abnormal_fertility/fecundity1.11025076
72MP0003828_pulmonary_edema1.09720031
73MP0001661_extended_life_span1.05286341
74MP0003111_abnormal_nucleus_morphology1.04923468
75MP0001984_abnormal_olfaction1.02619139
76MP0004215_abnormal_myocardial_fiber1.01999053
77MP0002822_catalepsy1.01080367
78MP0002557_abnormal_social/conspecific_i0.99062443
79MP0000343_altered_response_to0.95029858
80MP0003938_abnormal_ear_development0.92538349
81MP0005409_darkened_coat_color0.91383493
82MP0000653_abnormal_sex_gland0.90883973
83MP0001145_abnormal_male_reproductive0.90781696
84MP0002168_other_aberrant_phenotype0.90525350
85MP0002066_abnormal_motor_capabilities/c0.90485269
86MP0000631_abnormal_neuroendocrine_gland0.90281032
87MP0004272_abnormal_basement_membrane0.88926640
88MP0002295_abnormal_pulmonary_circulatio0.88854956
89MP0005395_other_phenotype0.88668270
90MP0001765_abnormal_ion_homeostasis0.86391810
91MP0002009_preneoplasia0.85756886
92MP0002184_abnormal_innervation0.84802964
93MP0004142_abnormal_muscle_tone0.84573210
94MP0001485_abnormal_pinna_reflex0.84450623
95MP0004185_abnormal_adipocyte_glucose0.84316485
96MP0002882_abnormal_neuron_morphology0.83306021
97MP0001502_abnormal_circadian_rhythm0.82733730
98MP0000470_abnormal_stomach_morphology0.79881028
99MP0008995_early_reproductive_senescence0.78244940
100MP0002152_abnormal_brain_morphology0.77657134
101MP0002233_abnormal_nose_morphology0.76163308
102MP0002638_abnormal_pupillary_reflex0.73907913
103MP0002249_abnormal_larynx_morphology0.73077783
104MP0005386_behavior/neurological_phenoty0.72932314
105MP0004924_abnormal_behavior0.72932314
106MP0003631_nervous_system_phenotype0.71961077
107MP0004085_abnormal_heartbeat0.71174245
108MP0001177_atelectasis0.70359846
109MP0004484_altered_response_of0.70343529
110MP0004084_abnormal_cardiac_muscle0.69561687
111MP0009384_cardiac_valve_regurgitation0.69023879
112MP0005253_abnormal_eye_physiology0.69000918
113MP0003315_abnormal_perineum_morphology0.68553447
114MP0006276_abnormal_autonomic_nervous0.68437763
115MP0002127_abnormal_cardiovascular_syste0.68220155
116MP0005595_abnormal_vascular_smooth0.67776438
117MP0005165_increased_susceptibility_to0.67176087
118MP0005423_abnormal_somatic_nervous0.66464813
119MP0003699_abnormal_female_reproductive0.65102336
120MP0003632_abnormal_nervous_system0.64869748
121MP0008874_decreased_physiological_sensi0.63957774
122MP0003861_abnormal_nervous_system0.63917603
123MP0000920_abnormal_myelination0.63700738
124MP0005248_abnormal_Harderian_gland0.63428222
125MP0009697_abnormal_copulation0.63190109
126MP0005174_abnormal_tail_pigmentation0.61763869
127MP0008057_abnormal_DNA_replication0.61477418
128MP0008789_abnormal_olfactory_epithelium0.61459214
129MP0003941_abnormal_skin_development0.60888528
130MP0003806_abnormal_nucleotide_metabolis0.60274433
131MP0001270_distended_abdomen0.60093086
132MP0000678_abnormal_parathyroid_gland0.58986267
133MP0000383_abnormal_hair_follicle0.58859129
134MP0002752_abnormal_somatic_nervous0.58785427
135MP0004885_abnormal_endolymph0.57662687
136MP0001346_abnormal_lacrimal_gland0.57380580
137MP0003091_abnormal_cell_migration0.57130326
138MP0003786_premature_aging0.56309835
139MP0000427_abnormal_hair_cycle0.54264906
140MP0003693_abnormal_embryo_hatching0.52261348
141MP0002090_abnormal_vision0.50957781
142MP0005367_renal/urinary_system_phenotyp0.50807415
143MP0000516_abnormal_urinary_system0.50807415
144MP0000230_abnormal_systemic_arterial0.50203738
145MP0001764_abnormal_homeostasis0.50121666
146MP0005620_abnormal_muscle_contractility0.49275473
147MP0003937_abnormal_limbs/digits/tail_de0.49256831
148MP0004381_abnormal_hair_follicle0.49169350
149MP0000049_abnormal_middle_ear0.47673694
150MP0003633_abnormal_nervous_system0.47101877
151MP0000762_abnormal_tongue_morphology0.45597945
152MP0008058_abnormal_DNA_repair0.43303068
153MP0004036_abnormal_muscle_relaxation0.42050551
154MP0005166_decreased_susceptibility_to0.40425862
155MP0001119_abnormal_female_reproductive0.39482568
156MP0000627_abnormal_mammary_gland0.39248350
157MP0002998_abnormal_bone_remodeling0.39186094
158MP0003385_abnormal_body_wall0.38832157
159MP0009250_abnormal_appendicular_skeleto0.38815929
160MP0010234_abnormal_vibrissa_follicle0.36605912
161MP0002115_abnormal_skeleton_extremities0.36238363
162MP0006035_abnormal_mitochondrial_morpho0.35345027
163MP0001756_abnormal_urination0.34468733
164MP0005391_vision/eye_phenotype0.33040100
165MP0000015_abnormal_ear_pigmentation0.32908652
166MP0003119_abnormal_digestive_system0.30691245

Predicted human phenotypes

RankGene SetZ-score
1Sex reversal (HP:0012245)9.84676520
2Abnormal sex determination (HP:0012244)9.84676520
3Gonadal dysgenesis (HP:0000133)7.72347733
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.62235002
5Resting tremor (HP:0002322)7.57403001
6Hypoplasia of the uterus (HP:0000013)7.55129083
7Focal motor seizures (HP:0011153)7.42131657
8Male pseudohermaphroditism (HP:0000037)5.93788120
9Aplasia/hypoplasia of the uterus (HP:0008684)5.69586373
10Reduced antithrombin III activity (HP:0001976)5.42343050
11Abnormality of the columella (HP:0009929)5.42172439
12Decreased circulating renin level (HP:0003351)5.14995410
13Dynein arm defect of respiratory motile cilia (HP:0012255)5.10948815
14Absent/shortened dynein arms (HP:0200106)5.10948815
15Tubulointerstitial nephritis (HP:0001970)4.98299676
16Colitis (HP:0002583)4.96128957
17Germ cell neoplasia (HP:0100728)4.95876249
18Abnormal respiratory motile cilium physiology (HP:0012261)4.91614979
19Postural instability (HP:0002172)4.69530676
20Rhinitis (HP:0012384)4.45677159
21Urinary urgency (HP:0000012)4.42667540
22Facial hemangioma (HP:0000329)4.40828802
23Nephronophthisis (HP:0000090)4.37946039
24Ventricular fibrillation (HP:0001663)4.36781326
25Thoracic kyphosis (HP:0002942)4.33515068
26Hyperkalemia (HP:0002153)4.21034934
27Abnormal ciliary motility (HP:0012262)3.95231025
28Thoracolumbar scoliosis (HP:0002944)3.85581493
29Visual hallucinations (HP:0002367)3.82937752
30Abnormality of male internal genitalia (HP:0000022)3.62267857
31Increased circulating renin level (HP:0000848)3.62124829
32Focal seizures (HP:0007359)3.60799208
33Abnormality of the lumbar spine (HP:0100712)3.59700887
34Cerebellar dysplasia (HP:0007033)3.58371981
35Abnormal respiratory epithelium morphology (HP:0012253)3.58287201
36Abnormal respiratory motile cilium morphology (HP:0005938)3.58287201
37Facial diplegia (HP:0001349)3.48199724
38Hyperactive renin-angiotensin system (HP:0000841)3.37181359
39Abnormality of the intrinsic pathway (HP:0010989)3.29759297
40Abnormality of the renal medulla (HP:0100957)3.27028025
41Inflammation of the large intestine (HP:0002037)3.19276463
42Confusion (HP:0001289)3.18503110
43Self-mutilation (HP:0000742)3.18432347
44Chronic bronchitis (HP:0004469)3.15739631
45Retinal dysplasia (HP:0007973)3.11919646
46Type II lissencephaly (HP:0007260)3.11150398
47Abnormality of dentin (HP:0010299)3.09462265
48Gastrointestinal inflammation (HP:0004386)3.02340544
49Generalized tonic-clonic seizures (HP:0002069)3.01362492
50Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.98691272
51Retinal atrophy (HP:0001105)2.93712630
52Protruding tongue (HP:0010808)2.92115224
53Capillary hemangiomas (HP:0005306)2.91846275
54Male infertility (HP:0003251)2.86745681
55Abnormality of the thoracic spine (HP:0100711)2.80326738
56Atonic seizures (HP:0010819)2.79121437
57Tubulointerstitial abnormality (HP:0001969)2.74294798
58Broad distal phalanx of finger (HP:0009836)2.72859678
59Myokymia (HP:0002411)2.67948815
60Febrile seizures (HP:0002373)2.67119520
61Epileptic encephalopathy (HP:0200134)2.66379322
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64101362
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64101362
64Diaphragmatic weakness (HP:0009113)2.63714095
65Pancreatic islet-cell hyperplasia (HP:0004510)2.63599194
66Stage 5 chronic kidney disease (HP:0003774)2.62991092
67Molar tooth sign on MRI (HP:0002419)2.61747662
68Abnormality of midbrain morphology (HP:0002418)2.61747662
69Progressive cerebellar ataxia (HP:0002073)2.59544008
70Nasal polyposis (HP:0100582)2.50106241
71Sensory axonal neuropathy (HP:0003390)2.48201804
72Infertility (HP:0000789)2.44838336
73Spastic tetraparesis (HP:0001285)2.44137384
74Abnormality of the frontal sinuses (HP:0002687)2.43294299
75Abnormality of alanine metabolism (HP:0010916)2.42749074
76Hyperalaninemia (HP:0003348)2.42749074
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42749074
78Hyperinsulinemic hypoglycemia (HP:0000825)2.41578637
79Buphthalmos (HP:0000557)2.36660218
80Gaze-evoked nystagmus (HP:0000640)2.35718241
81Thickened helices (HP:0000391)2.34824500
82Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.34649988
83Testicular neoplasm (HP:0010788)2.33399169
84Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.32832427
85Congenital sensorineural hearing impairment (HP:0008527)2.28626571
86Abnormality of renin-angiotensin system (HP:0000847)2.27670508
87Unsteady gait (HP:0002317)2.27573134
88Short nail (HP:0001799)2.27155152
89Abnormality of the nasal mucosa (HP:0000433)2.26752610
90Toxemia of pregnancy (HP:0100603)2.26050988
91Fibular hypoplasia (HP:0003038)2.25311327
92Inability to walk (HP:0002540)2.25225347
93Occipital encephalocele (HP:0002085)2.24341091
94Hemiparesis (HP:0001269)2.20331210
95Broad-based gait (HP:0002136)2.19833500
96Oligodactyly (hands) (HP:0001180)2.19770855
97Tubular atrophy (HP:0000092)2.19000386
98Amblyopia (HP:0000646)2.18310775
99Insulin-resistant diabetes mellitus (HP:0000831)2.18268398
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.17205198
101Abnormality of binocular vision (HP:0011514)2.17022227
102Diplopia (HP:0000651)2.17022227
103Hypothermia (HP:0002045)2.15991420
104Epileptiform EEG discharges (HP:0011182)2.15614297
105Spontaneous abortion (HP:0005268)2.14895881
106Anterior segment dysgenesis (HP:0007700)2.12215478
107Abnormality of the axillary hair (HP:0100134)2.11786869
108Abnormality of secondary sexual hair (HP:0009888)2.11786869
109Absent thumb (HP:0009777)2.11176557
110Vitreoretinal degeneration (HP:0000655)2.07106381
111Widely spaced teeth (HP:0000687)2.06497201
112Hyperaldosteronism (HP:0000859)2.05131223
113Excessive salivation (HP:0003781)2.04098254
114Drooling (HP:0002307)2.04098254
115Fair hair (HP:0002286)2.02915886
116Hemiplegia (HP:0002301)2.02367670
117Cerebral inclusion bodies (HP:0100314)2.00150642
118Prolonged QT interval (HP:0001657)1.99728940
119Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98776701
120True hermaphroditism (HP:0010459)1.96342988
121Abnormality of the ileum (HP:0001549)1.92172804
122Megaloblastic anemia (HP:0001889)1.90130437
123Polyneuropathy (HP:0001271)1.88631135
124Impulsivity (HP:0100710)1.86684475
125Coxa valga (HP:0002673)1.85080325
126Postaxial foot polydactyly (HP:0001830)1.83553258
127Neurofibrillary tangles (HP:0002185)1.82992652
128Spinal rigidity (HP:0003306)1.82484175
129Upper limb muscle weakness (HP:0003484)1.80880165
130Chin dimple (HP:0010751)1.80551898
131Median cleft lip (HP:0000161)1.79892383
132High anterior hairline (HP:0009890)1.79762849
133Stridor (HP:0010307)1.79442693
134Abnormality of potassium homeostasis (HP:0011042)1.78730816
135Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78350060
136Depression (HP:0000716)1.76542315
137Chronic sinusitis (HP:0011109)1.75492408
138Aplasia/Hypoplasia of the uvula (HP:0010293)1.74025098
139Segmental peripheral demyelination/remyelination (HP:0003481)1.73506194
140Decreased motor nerve conduction velocity (HP:0003431)1.73251999
141Exotropia (HP:0000577)1.72959979
142Global brain atrophy (HP:0002283)1.72393758
143External ophthalmoplegia (HP:0000544)1.72350141
144Absent speech (HP:0001344)1.71912669
145Bradykinesia (HP:0002067)1.70469052
146Meckel diverticulum (HP:0002245)1.70466038
147Nephroblastoma (Wilms tumor) (HP:0002667)1.66453214
148EEG with generalized epileptiform discharges (HP:0011198)1.65859756
149Aortic aneurysm (HP:0004942)1.65314962
150Premature rupture of membranes (HP:0001788)1.65265456
151Hypsarrhythmia (HP:0002521)1.65185525
152Absence seizures (HP:0002121)1.65083901
153Pancreatic fibrosis (HP:0100732)1.64195116
154Syncope (HP:0001279)1.63788603
155Gonadotropin excess (HP:0000837)1.62754589
156Absent hair (HP:0002298)1.62725859
157Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61890694
158Abnormal protein N-linked glycosylation (HP:0012347)1.61890694
159Abnormal protein glycosylation (HP:0012346)1.61890694
160Abnormal glycosylation (HP:0012345)1.61890694
161Sparse lateral eyebrow (HP:0005338)1.61656058
162Dysmetria (HP:0001310)1.61452963
163Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.61291694
164Bronchiectasis (HP:0002110)1.61158688
165Metabolic alkalosis (HP:0200114)1.59919890
166Embryonal renal neoplasm (HP:0011794)1.59643103
167Hypotension (HP:0002615)1.59557040
168Nuclear cataract (HP:0100018)1.59540230
169Ulnar claw (HP:0001178)1.58403925
170Short humerus (HP:0005792)1.58286534
171Abnormality of the dental pulp (HP:0006479)1.55706941
172Centrally nucleated skeletal muscle fibers (HP:0003687)1.55066811
173Exercise-induced myalgia (HP:0003738)1.54743147
174Clumsiness (HP:0002312)1.53752872
175Intellectual disability, progressive (HP:0006887)1.52849103
176Myoglobinuria (HP:0002913)1.51348483
177Flattened epiphyses (HP:0003071)1.50592211
178Aplasia cutis congenita (HP:0001057)1.50230592
179Optic nerve hypoplasia (HP:0000609)1.49556067
180Abnormality of the vitreous humor (HP:0004327)1.49384128
181Renal dysplasia (HP:0000110)1.49071730
182Hypoventilation (HP:0002791)1.47730561
183Generalized hypotonia (HP:0001290)1.47196588
184Bulbar palsy (HP:0001283)1.46003176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK39.48143645
2MARK36.30787436
3EPHA45.20264163
4TLK13.96202751
5MYLK3.47616030
6PRPF4B3.13995654
7MAP3K63.11041299
8RPS6KA53.02961368
9MAP3K42.87954148
10FES2.77218225
11MAP2K72.71827680
12PNCK2.47873555
13FER2.29826024
14LATS12.05353766
15PINK111.9787753
16PAK61.75335171
17MOS1.71644917
18MAP2K41.52496650
19CAMK2B1.48294349
20TAOK21.46208514
21CDC71.42291934
22TNIK1.41678506
23DYRK31.36322973
24TTK1.36155135
25MAPK131.31304184
26PDK31.22908928
27PDK41.22908928
28PTK2B1.22371810
29AKT31.21859730
30CAMK2D1.18946407
31FGR1.18733003
32SGK4941.13358048
33SGK2231.13358048
34CSNK1A1L1.11277590
35KSR11.00785332
36NEK20.99264356
37STK380.96205574
38CSNK1G30.95542553
39BUB10.95496673
40CAMK2A0.94074029
41MAP3K90.93078485
42LATS20.92244331
43SIK20.91778084
44MAP3K130.91397569
45CHEK20.86992102
46FRK0.86462067
47IRAK20.86041839
48ABL20.85898505
49PRKCQ0.85613035
50PRKD30.84814827
51PRKCG0.84246470
52MST1R0.84050436
53DDR20.81564051
54VRK10.80209438
55MAP3K50.78146380
56ARAF0.77573275
57BRAF0.76789784
58CDK30.76096153
59PLK30.75620340
60CDC42BPA0.74180005
61CSNK1G10.73487909
62CDK50.73291473
63CAMK2G0.72812394
64MAP3K100.72789204
65PRKCE0.72162307
66BMPR20.72040641
67TYRO30.70647666
68CSNK1E0.69880255
69OBSCN0.67236103
70CDK150.67041064
71CDK80.65348346
72BMPR1B0.65217923
73ZAK0.63944052
74GRK10.61808318
75CASK0.59947166
76KSR20.59875687
77CDK180.59599987
78PDK20.58170949
79PLK10.56135844
80PAK10.53432263
81MAP3K10.53428317
82SGK10.52220212
83CDK11A0.51957919
84DAPK30.51459080
85CDK140.50257527
86CSNK1G20.49339918
87PAK30.48740805
88ADRBK20.48516228
89EIF2AK30.46954043
90RPS6KB10.45612758
91DYRK20.44042905
92PAK20.43678129
93TGFBR10.43673518
94PLK20.41845604
95SGK20.41520918
96FGFR20.41216603
97MAP2K10.38918174
98CCNB10.38721195
99TIE10.38557602
100NEK60.38469739
101WNK10.37970754
102ROCK10.35112429
103NTRK20.35091708
104WEE10.35078186
105CDK70.34979226
106EGFR0.34508213
107PRKG20.34352783
108PDGFRB0.34078935
109MAPKAPK30.33788342
110MAPK150.33643088
111PRKACA0.32689928
112PKN10.32307576
113NME20.32181468
114EPHA20.31810361
115PRKACB0.31714193
116STK390.31189778
117PKN20.31159482
118ICK0.31046555
119NME10.29693233
120PDPK10.29291150
121STK30.29284125
122STK160.28582564
123CAMK10.28298707
124CSNK1A10.28185159
125RET0.27008145
126PRKG10.26828719
127GRK50.26710910
128GSK3B0.26593723
129RPS6KA40.26246870
130STK38L0.25945080
131RIPK40.25673538
132MAPK120.23906099
133MAP3K20.23876016
134AKT20.23319948
135PIM10.23091437
136ILK0.22468283
137TESK10.22241400
138PRKDC0.22212378
139ATM0.21269780
140RPS6KA10.21014555
141MELK0.20741577
142IRAK10.20521539
143ROCK20.19900096
144RPS6KA30.19509162
145CDK10.19451319
146CLK10.17951576
147PDK10.16579704
148GRK60.15991019
149CDK120.15978304
150STK40.13524918
151BTK0.13374827
152EEF2K0.13189429
153MAPK10.13116526
154MTOR0.11958198
155AURKB0.11900727
156SGK30.11313018
157MINK10.08978658
158MAP4K20.06670326
159AURKA0.05546467
160CSNK1D0.05457882
161RPS6KA20.03945455
162PRKAA10.02683025
163CSNK2A10.01462386

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051308.52671999
2Nicotine addiction_Homo sapiens_hsa050334.36414862
3Vitamin B6 metabolism_Homo sapiens_hsa007503.84555598
4Systemic lupus erythematosus_Homo sapiens_hsa053223.52730501
5Glutamatergic synapse_Homo sapiens_hsa047243.39735617
6Nitrogen metabolism_Homo sapiens_hsa009103.36793256
7Apoptosis_Homo sapiens_hsa042103.28290282
8Circadian entrainment_Homo sapiens_hsa047133.25282599
9Phagosome_Homo sapiens_hsa041453.18976634
10Long-term potentiation_Homo sapiens_hsa047202.92776832
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71121408
12Taste transduction_Homo sapiens_hsa047422.60733749
13Arginine biosynthesis_Homo sapiens_hsa002202.60549939
14Alcoholism_Homo sapiens_hsa050342.59708957
15Amphetamine addiction_Homo sapiens_hsa050312.57641628
16Propanoate metabolism_Homo sapiens_hsa006402.44551502
17Type II diabetes mellitus_Homo sapiens_hsa049302.32044102
18Long-term depression_Homo sapiens_hsa047302.31339280
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.23891155
20GABAergic synapse_Homo sapiens_hsa047272.21430218
21Cocaine addiction_Homo sapiens_hsa050302.05512989
22Circadian rhythm_Homo sapiens_hsa047102.04489101
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.02604581
24Morphine addiction_Homo sapiens_hsa050322.00340384
25Calcium signaling pathway_Homo sapiens_hsa040201.89199316
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82732146
27Dopaminergic synapse_Homo sapiens_hsa047281.80070692
28Glutathione metabolism_Homo sapiens_hsa004801.73536518
29Serotonergic synapse_Homo sapiens_hsa047261.69399876
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68210226
31Pyruvate metabolism_Homo sapiens_hsa006201.67713155
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55799282
33Butanoate metabolism_Homo sapiens_hsa006501.54854862
34Estrogen signaling pathway_Homo sapiens_hsa049151.54230820
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.49475995
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.48158121
37Vitamin digestion and absorption_Homo sapiens_hsa049771.46610767
38Oxytocin signaling pathway_Homo sapiens_hsa049211.44949297
39Oocyte meiosis_Homo sapiens_hsa041141.44539045
40GnRH signaling pathway_Homo sapiens_hsa049121.41316774
41cAMP signaling pathway_Homo sapiens_hsa040241.38694702
42Dorso-ventral axis formation_Homo sapiens_hsa043201.37191993
43Cholinergic synapse_Homo sapiens_hsa047251.36296668
44Insulin secretion_Homo sapiens_hsa049111.34270697
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31369293
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24102706
47Salivary secretion_Homo sapiens_hsa049701.23980217
48Phospholipase D signaling pathway_Homo sapiens_hsa040721.22280895
49Gastric acid secretion_Homo sapiens_hsa049711.19053569
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.15066783
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14297460
52Synaptic vesicle cycle_Homo sapiens_hsa047211.14013420
53Choline metabolism in cancer_Homo sapiens_hsa052311.12480064
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09160634
55Ovarian steroidogenesis_Homo sapiens_hsa049131.07725445
56Chemical carcinogenesis_Homo sapiens_hsa052041.07016458
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03247500
58Glycerophospholipid metabolism_Homo sapiens_hsa005641.01790476
59Mineral absorption_Homo sapiens_hsa049781.00704674
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96032262
61Axon guidance_Homo sapiens_hsa043600.92843478
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92515402
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92371035
64ErbB signaling pathway_Homo sapiens_hsa040120.92320790
65Renin secretion_Homo sapiens_hsa049240.91029119
66Fanconi anemia pathway_Homo sapiens_hsa034600.90812705
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90243998
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86790607
69Glycerolipid metabolism_Homo sapiens_hsa005610.86448306
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85270067
71Phenylalanine metabolism_Homo sapiens_hsa003600.84064513
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83165583
73TGF-beta signaling pathway_Homo sapiens_hsa043500.80826966
74PPAR signaling pathway_Homo sapiens_hsa033200.78938199
75Pentose phosphate pathway_Homo sapiens_hsa000300.77886821
76Dilated cardiomyopathy_Homo sapiens_hsa054140.77537961
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77487825
78Tryptophan metabolism_Homo sapiens_hsa003800.70606748
79Ether lipid metabolism_Homo sapiens_hsa005650.69329617
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68745926
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67104491
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67034299
83Basal transcription factors_Homo sapiens_hsa030220.65934289
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65692738
85MAPK signaling pathway_Homo sapiens_hsa040100.65641910
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64799392
87Gap junction_Homo sapiens_hsa045400.61689327
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61135783
89Ras signaling pathway_Homo sapiens_hsa040140.60151577
90Cell cycle_Homo sapiens_hsa041100.59990681
91Phototransduction_Homo sapiens_hsa047440.59488318
92Sphingolipid metabolism_Homo sapiens_hsa006000.59336323
93mRNA surveillance pathway_Homo sapiens_hsa030150.59262064
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59228474
95Melanogenesis_Homo sapiens_hsa049160.58515939
96Selenocompound metabolism_Homo sapiens_hsa004500.58441081
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.58223300
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57488671
99Glucagon signaling pathway_Homo sapiens_hsa049220.57055377
100Olfactory transduction_Homo sapiens_hsa047400.56656233
101Purine metabolism_Homo sapiens_hsa002300.54657858
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54374086
103Thyroid hormone synthesis_Homo sapiens_hsa049180.53639204
104Collecting duct acid secretion_Homo sapiens_hsa049660.51794988
105ECM-receptor interaction_Homo sapiens_hsa045120.50272176
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49982188
107Pancreatic secretion_Homo sapiens_hsa049720.47210066
108RNA degradation_Homo sapiens_hsa030180.46252085
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43851186
110beta-Alanine metabolism_Homo sapiens_hsa004100.43247967
111Wnt signaling pathway_Homo sapiens_hsa043100.43219634
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42719425
113Graft-versus-host disease_Homo sapiens_hsa053320.42166564
114Inositol phosphate metabolism_Homo sapiens_hsa005620.41848832
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41131153
116Cardiac muscle contraction_Homo sapiens_hsa042600.40820969
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37961516
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37853284
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36176988
120Fatty acid degradation_Homo sapiens_hsa000710.35780851
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.35440453
122Prion diseases_Homo sapiens_hsa050200.35212558
123Regulation of autophagy_Homo sapiens_hsa041400.34938861
124Tyrosine metabolism_Homo sapiens_hsa003500.32777459
125Endometrial cancer_Homo sapiens_hsa052130.31737728
126Linoleic acid metabolism_Homo sapiens_hsa005910.30577022
127Bile secretion_Homo sapiens_hsa049760.30458135
128Carbon metabolism_Homo sapiens_hsa012000.27268953
129Hedgehog signaling pathway_Homo sapiens_hsa043400.26055386
130Tight junction_Homo sapiens_hsa045300.25893153
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.25701451
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.24942757
133RNA transport_Homo sapiens_hsa030130.23925648
134N-Glycan biosynthesis_Homo sapiens_hsa005100.23627466
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23385761
136Metabolic pathways_Homo sapiens_hsa011000.22994036
137Prostate cancer_Homo sapiens_hsa052150.22523467
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20685740
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20394181
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20294107
141Glioma_Homo sapiens_hsa052140.18972882
142African trypanosomiasis_Homo sapiens_hsa051430.18801643
143Fatty acid biosynthesis_Homo sapiens_hsa000610.18759683
144Arginine and proline metabolism_Homo sapiens_hsa003300.16915750
145Fatty acid metabolism_Homo sapiens_hsa012120.16730714
146B cell receptor signaling pathway_Homo sapiens_hsa046620.16467466
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16342744
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16099550
149mTOR signaling pathway_Homo sapiens_hsa041500.15792479
150T cell receptor signaling pathway_Homo sapiens_hsa046600.14281147
151Melanoma_Homo sapiens_hsa052180.12566302
152Viral carcinogenesis_Homo sapiens_hsa052030.11297674
153Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.09313489
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.08721991
155Peroxisome_Homo sapiens_hsa041460.08076682
156Retinol metabolism_Homo sapiens_hsa008300.06388546
157Focal adhesion_Homo sapiens_hsa045100.05669299

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »