TRPC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)6.58461741
2negative regulation of erythrocyte differentiation (GO:0045647)5.66171039
3positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.62233893
4platelet dense granule organization (GO:0060155)5.50387440
5mature B cell differentiation involved in immune response (GO:0002313)5.47444706
6ribosomal small subunit assembly (GO:0000028)5.09533907
7regulation of integrin-mediated signaling pathway (GO:2001044)4.89325055
8heparin metabolic process (GO:0030202)4.81701935
9heparin biosynthetic process (GO:0030210)4.81701935
10negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.71571660
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.66203458
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.57827053
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.49713179
14phospholipid scrambling (GO:0017121)4.46167805
15dopamine transport (GO:0015872)4.39350220
16response to interferon-beta (GO:0035456)4.36091851
17protein localization to cilium (GO:0061512)4.34675865
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.27018116
19kidney mesenchyme development (GO:0072074)4.23091277
20negative regulation of dendrite morphogenesis (GO:0050774)4.15565898
21mesenchymal cell development (GO:0014031)4.08944152
22regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.04080922
23megakaryocyte development (GO:0035855)4.02562931
24neurotransmitter-gated ion channel clustering (GO:0072578)3.99073263
25positive regulation of dendritic spine morphogenesis (GO:0061003)3.96497692
26regulation of inositol phosphate biosynthetic process (GO:0010919)3.94198388
27Notch signaling involved in heart development (GO:0061314)3.93683958
28negative regulation of homotypic cell-cell adhesion (GO:0034111)3.92138824
29mature B cell differentiation (GO:0002335)3.90462853
30cell migration involved in heart development (GO:0060973)3.85800188
31metanephric mesenchyme development (GO:0072075)3.84366961
32relaxation of smooth muscle (GO:0044557)3.83983831
33dermatan sulfate biosynthetic process (GO:0030208)3.80107162
34regulation of vasculogenesis (GO:2001212)3.79843140
35daunorubicin metabolic process (GO:0044597)3.78835859
36polyketide metabolic process (GO:0030638)3.78835859
37doxorubicin metabolic process (GO:0044598)3.78835859
38cyclic nucleotide catabolic process (GO:0009214)3.77706274
39sulfation (GO:0051923)3.72606045
40Peyers patch development (GO:0048541)3.72340221
41mucosal-associated lymphoid tissue development (GO:0048537)3.72340221
42regulation of dopamine secretion (GO:0014059)3.68945178
43negative regulation of platelet activation (GO:0010544)3.67854341
44positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.66756634
45regulation of axon regeneration (GO:0048679)3.64919715
46regulation of neuron projection regeneration (GO:0070570)3.64919715
47nerve growth factor signaling pathway (GO:0038180)3.64351294
48regulation of endothelial cell differentiation (GO:0045601)3.56980147
49positive regulation of receptor internalization (GO:0002092)3.56571619
50activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.54669400
51neural crest cell development (GO:0014032)3.53333413
52renal tubule morphogenesis (GO:0061333)3.52387702
53negative regulation of dendrite development (GO:2000171)3.52349413
54glutamate receptor signaling pathway (GO:0007215)3.52069783
55intracellular pH reduction (GO:0051452)3.47616128
56synaptic transmission, glutamatergic (GO:0035249)3.45879053
57cAMP catabolic process (GO:0006198)3.45779513
58regulation of long-term neuronal synaptic plasticity (GO:0048169)3.44844663
59lymph node development (GO:0048535)3.43514889
60gamma-aminobutyric acid transport (GO:0015812)3.43056366
61stem cell development (GO:0048864)3.42644107
62regulation of glutamate receptor signaling pathway (GO:1900449)3.42406911
63catecholamine transport (GO:0051937)3.42182896
64lymph vessel development (GO:0001945)3.40907908
65aorta morphogenesis (GO:0035909)3.38242567
66regulation of platelet aggregation (GO:0090330)3.36901216
67negative regulation of stress fiber assembly (GO:0051497)3.32963475
68positive regulation of respiratory burst (GO:0060267)3.31496992
69positive regulation of phosphatase activity (GO:0010922)3.31404629
70mitotic cell cycle arrest (GO:0071850)3.30044060
71synaptic vesicle maturation (GO:0016188)3.29825103
72negative regulation of axon extension involved in axon guidance (GO:0048843)3.29599937
73dermatan sulfate metabolic process (GO:0030205)3.28408725
74positive regulation of endothelial cell differentiation (GO:0045603)3.25958780
75pH reduction (GO:0045851)3.25852075
76cellular response to ammonium ion (GO:0071242)3.25837006
77regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25532708
78negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.25219329
79negative regulation of T-helper cell differentiation (GO:0045623)3.25219329
80exploration behavior (GO:0035640)3.24506204
81presynaptic membrane assembly (GO:0097105)3.22366073
82serotonin metabolic process (GO:0042428)3.21976154
83neuron-neuron synaptic transmission (GO:0007270)3.20145483
84extracellular fibril organization (GO:0043206)3.16000378
85endocardial cushion morphogenesis (GO:0003203)3.15453610
86antigen processing and presentation via MHC class Ib (GO:0002475)3.13839450
87cardiac right ventricle morphogenesis (GO:0003215)3.13767966
88cGMP-mediated signaling (GO:0019934)3.12294513
89oligosaccharide biosynthetic process (GO:0009312)3.11687630
90behavioral fear response (GO:0001662)3.10212353
91behavioral defense response (GO:0002209)3.10212353
92smooth muscle tissue development (GO:0048745)3.10140013
93secretory granule organization (GO:0033363)3.10086511
94cerebellar Purkinje cell differentiation (GO:0021702)3.09928891
95positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.09417701
96cGMP biosynthetic process (GO:0006182)3.08905089
97negative regulation of neurological system process (GO:0031645)3.07752283
98positive regulation of gamma-delta T cell activation (GO:0046645)3.06455479
99establishment of tissue polarity (GO:0007164)3.06055600
100establishment of planar polarity (GO:0001736)3.06055600
101negative regulation of smooth muscle cell differentiation (GO:0051151)3.05457136
102glomerular filtration (GO:0003094)3.05283462
103peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.04980509
104response to histamine (GO:0034776)3.03626122
105regulation of synaptic transmission, glutamatergic (GO:0051966)3.03441977
106thrombin receptor signaling pathway (GO:0070493)3.03285095
107regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.02090967
108potassium ion import (GO:0010107)3.01985772
109cellular extravasation (GO:0045123)2.99744498
110postsynaptic membrane organization (GO:0001941)2.98693654
111heart valve morphogenesis (GO:0003179)2.98409138
112auditory receptor cell differentiation (GO:0042491)2.98376022
113synaptic vesicle exocytosis (GO:0016079)2.97975182
114regulation of neuronal synaptic plasticity (GO:0048168)2.97262752
115glomerulus development (GO:0032835)2.97222586
116phagocytosis, recognition (GO:0006910)2.95700805
117glutamate secretion (GO:0014047)2.95665364
118endosome to pigment granule transport (GO:0043485)2.92666684
119endosome to melanosome transport (GO:0035646)2.92666684
120facial nerve structural organization (GO:0021612)2.91917120
121adenosine metabolic process (GO:0046085)2.91383002
122protein localization to synapse (GO:0035418)2.91335129
123tonic smooth muscle contraction (GO:0014820)2.90775458
124regulation of postsynaptic membrane potential (GO:0060078)2.90071714
125response to interferon-alpha (GO:0035455)2.89887176
126inositol phosphate catabolic process (GO:0071545)2.89859958
127negative regulation of axon guidance (GO:1902668)2.89743513
128negative regulation of norepinephrine secretion (GO:0010700)2.89486341
129epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.86599504
130gonadal mesoderm development (GO:0007506)2.86530019
131cGMP metabolic process (GO:0046068)2.85231292
132L-fucose catabolic process (GO:0042355)2.84765064
133fucose catabolic process (GO:0019317)2.84765064
134L-fucose metabolic process (GO:0042354)2.84765064
135regulation of cilium movement (GO:0003352)2.83217495
136positive regulation of synaptic transmission, GABAergic (GO:0032230)2.82539988
137cell proliferation involved in metanephros development (GO:0072203)2.82455246
138locomotory exploration behavior (GO:0035641)2.82417875
139positive regulation of endothelial cell apoptotic process (GO:2000353)2.80966047
140negative regulation of actin filament bundle assembly (GO:0032232)2.80577973
141negative regulation of muscle contraction (GO:0045932)2.80282394
142behavioral response to nicotine (GO:0035095)2.80045429
143respiratory chain complex IV assembly (GO:0008535)2.79240106
144negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.77933877
145surfactant homeostasis (GO:0043129)2.77645418
146regulation of cellular respiration (GO:0043457)2.77632141
147neuronal action potential (GO:0019228)2.74532944
148primary amino compound metabolic process (GO:1901160)2.74313927
149negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.73883570
150negative regulation of androgen receptor signaling pathway (GO:0060766)2.73293027
151positive regulation of catenin import into nucleus (GO:0035413)2.72611263
152positive regulation of smooth muscle cell migration (GO:0014911)2.72163290
153regulation of dendritic spine morphogenesis (GO:0061001)2.69859358
154blood coagulation, intrinsic pathway (GO:0007597)2.69628798
155proline transport (GO:0015824)2.69452237
156positive regulation of catecholamine secretion (GO:0033605)2.67896786
157fear response (GO:0042596)2.66966885
158positive regulation of natural killer cell differentiation (GO:0032825)2.66385100
159regulation of platelet activation (GO:0010543)2.66218690
160negative regulation of membrane potential (GO:0045837)2.65756437
161synaptic vesicle docking involved in exocytosis (GO:0016081)2.65197160
162positive regulation of membrane potential (GO:0045838)2.64650676
163regulation of axon extension involved in axon guidance (GO:0048841)2.64449981
164relaxation of muscle (GO:0090075)2.64261463
165parturition (GO:0007567)2.63653526
166renal filtration (GO:0097205)2.60614003
167sequestering of extracellular ligand from receptor (GO:0035581)2.57328144
168positive regulation of actin filament depolymerization (GO:0030836)2.56052080
169nephron tubule development (GO:0072080)2.55146191
170chemical homeostasis within a tissue (GO:0048875)2.54796600
171mesenchyme morphogenesis (GO:0072132)2.53308220
172retina vasculature morphogenesis in camera-type eye (GO:0061299)2.51511094
173negative regulation of cytosolic calcium ion concentration (GO:0051481)2.49191567
174endothelium development (GO:0003158)2.47762031
175regulation of axon guidance (GO:1902667)2.46325230
176ventricular septum morphogenesis (GO:0060412)2.42544647
177regulation of hippo signaling (GO:0035330)2.42123533
178positive regulation of vasculogenesis (GO:2001214)2.41790865
179acrosome assembly (GO:0001675)2.39517774
180basement membrane organization (GO:0071711)2.39106417
181epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.37952024
182establishment of epithelial cell polarity (GO:0090162)2.37765947
183cardiac epithelial to mesenchymal transition (GO:0060317)2.37125936
184vascular endothelial growth factor signaling pathway (GO:0038084)2.36280875
185fibril organization (GO:0097435)2.35901034
186renal tubule development (GO:0061326)2.35830452
187protein neddylation (GO:0045116)2.35002750
188regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.34475101
189platelet aggregation (GO:0070527)2.33973577
190vasculature development (GO:0001944)2.33543490
191outflow tract morphogenesis (GO:0003151)2.33328809
192nephron epithelium development (GO:0072009)2.32765613
193negative regulation of smooth muscle cell migration (GO:0014912)2.31520653
194negative regulation of protein localization to cell surface (GO:2000009)2.31000476
195cochlea development (GO:0090102)2.30896162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.38588567
2SCL_19346495_ChIP-Seq_HPC-7_Human4.29781800
3TAF15_26573619_Chip-Seq_HEK293_Human4.27973224
4EZH2_22144423_ChIP-Seq_EOC_Human4.03019818
5IGF1R_20145208_ChIP-Seq_DFB_Human3.13928827
6GATA1_22025678_ChIP-Seq_K562_Human2.90331085
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.87993856
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74746498
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.69547445
10VDR_22108803_ChIP-Seq_LS180_Human2.52702185
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.38585878
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37473021
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25243676
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.23198928
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14918502
16GATA2_21666600_ChIP-Seq_HMVEC_Human2.14149514
17ZNF274_21170338_ChIP-Seq_K562_Hela2.09093376
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04467175
19FUS_26573619_Chip-Seq_HEK293_Human1.99390699
20* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98438630
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93861408
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89019904
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87759864
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87296127
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86899631
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86504504
27* P300_19829295_ChIP-Seq_ESCs_Human1.84439599
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82336819
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80566424
30* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78319350
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78238838
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.73715779
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.73715779
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73641676
35* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72376094
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70964779
37* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70337975
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70079659
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69503295
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.69022284
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67733417
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.64701638
43* EWS_26573619_Chip-Seq_HEK293_Human1.63792987
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62202424
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61186576
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61186576
47BCAT_22108803_ChIP-Seq_LS180_Human1.60330280
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.59931134
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.59791025
50* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58890640
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.56558234
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54737401
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54434433
54* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53057780
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52123792
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50959424
57* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49878216
58CJUN_26792858_Chip-Seq_BT549_Human1.48541402
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48410669
60REST_21632747_ChIP-Seq_MESCs_Mouse1.47719642
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.47386026
62AR_25329375_ChIP-Seq_VCAP_Human1.41593311
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41432239
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.40967480
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.40721106
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.40594756
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39321003
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.37563738
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37512327
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37473450
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37114477
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.36838240
73* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36627130
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36163944
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34364100
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34325834
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34009202
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32795881
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.32190970
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31927220
81SPI1_23127762_ChIP-Seq_K562_Human1.31810000
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31235141
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31229121
84RUNX_20019798_ChIP-Seq_JUKART_Human1.31000924
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30386637
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28972321
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28312071
88AHR_22903824_ChIP-Seq_MCF-7_Human1.27462012
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26745986
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26684239
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.26290472
92STAT3_23295773_ChIP-Seq_U87_Human1.26194557
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24687193
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24141433
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23433127
96* RNF2_27304074_Chip-Seq_NSC_Mouse1.22421552
97TCF4_23295773_ChIP-Seq_U87_Human1.21875798
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21669131
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21136486
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.20220185
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.18076195
102TP53_18474530_ChIP-ChIP_U2OS_Human1.17757602
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16988696
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16566219
105DROSHA_22980978_ChIP-Seq_HELA_Human1.16049398
106AR_21572438_ChIP-Seq_LNCaP_Human1.15927343
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14388261
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.13751747
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.13657126
110REST_18959480_ChIP-ChIP_MESCs_Mouse1.13275734
111TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13225310
112MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12757503
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.12408318
114ER_23166858_ChIP-Seq_MCF-7_Human1.09749025
115TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08573857
116TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08550130
117RNF2_27304074_Chip-Seq_ESCs_Mouse1.08309122
118RUNX2_22187159_ChIP-Seq_PCA_Human1.08053274
119JUN_21703547_ChIP-Seq_K562_Human1.06433413
120WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06222224
121KDM2B_26808549_Chip-Seq_REH_Human1.06119320
122SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06077601
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05933873
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05727684
125P53_22387025_ChIP-Seq_ESCs_Mouse1.05463719
126NOTCH1_21737748_ChIP-Seq_TLL_Human1.04315420
127CBP_20019798_ChIP-Seq_JUKART_Human1.03940981
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03940981
129TP53_16413492_ChIP-PET_HCT116_Human1.02903109
130RXR_22108803_ChIP-Seq_LS180_Human1.01341670
131HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01285334
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00720965
133SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00470804
134* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99357144
135* TCF4_22108803_ChIP-Seq_LS180_Human0.98223051
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97962162
137MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97819379
138TCF4_18268006_ChIP-ChIP_LS174T_Human0.97580223
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97296622
140IRF1_19129219_ChIP-ChIP_H3396_Human0.96280578
141* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96266131
142GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95830170
143LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95065026
144HTT_18923047_ChIP-ChIP_STHdh_Human0.92678055
145PRDM14_20953172_ChIP-Seq_ESCs_Human0.91799224
146* TAL1_26923725_Chip-Seq_HPCs_Mouse0.91307852
147HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89118415
148KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87580209
149SOX2_21211035_ChIP-Seq_LN229_Gbm0.87578332
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.87069694
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85214289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.39102513
2MP0008438_abnormal_cutaneous_collagen4.75619092
3MP0003880_abnormal_central_pattern4.35769090
4MP0004272_abnormal_basement_membrane4.33175567
5MP0005503_abnormal_tendon_morphology4.02863014
6MP0002735_abnormal_chemical_nociception3.63828878
7MP0002736_abnormal_nociception_after3.59648175
8MP0009384_cardiac_valve_regurgitation3.56492205
9MP0005275_abnormal_skin_tensile3.45347641
10MP0001968_abnormal_touch/_nociception3.43051777
11MP0002822_catalepsy3.42469191
12MP0001986_abnormal_taste_sensitivity3.24103793
13MP0003279_aneurysm3.08566852
14MP0001958_emphysema3.05869941
15MP0009745_abnormal_behavioral_response2.91731025
16MP0003635_abnormal_synaptic_transmissio2.79283801
17MP0008004_abnormal_stomach_pH2.67344020
18MP0004147_increased_porphyrin_level2.59518249
19MP0004808_abnormal_hematopoietic_stem2.46156779
20MP0003136_yellow_coat_color2.42277968
21MP0003566_abnormal_cell_adhesion2.38933619
22MP0001905_abnormal_dopamine_level2.25575560
23MP0001501_abnormal_sleep_pattern2.20908541
24MP0002272_abnormal_nervous_system2.17701486
25MP0002064_seizures2.10698058
26MP0002063_abnormal_learning/memory/cond2.07531433
27MP0001542_abnormal_bone_strength2.06288266
28MP0005171_absent_coat_pigmentation1.96055243
29MP0005464_abnormal_platelet_physiology1.90998385
30* MP0000230_abnormal_systemic_arterial1.88904647
31MP0002572_abnormal_emotion/affect_behav1.87982418
32MP0002876_abnormal_thyroid_physiology1.87544420
33MP0002102_abnormal_ear_morphology1.82698094
34MP0008877_abnormal_DNA_methylation1.79537918
35MP0009697_abnormal_copulation1.74749285
36MP0000372_irregular_coat_pigmentation1.73831887
37MP0000465_gastrointestinal_hemorrhage1.69805688
38MP0002638_abnormal_pupillary_reflex1.69660618
39MP0000534_abnormal_ureter_morphology1.69187164
40MP0005409_darkened_coat_color1.66158027
41* MP0005595_abnormal_vascular_smooth1.64509141
42MP0005174_abnormal_tail_pigmentation1.62168814
43MP0003950_abnormal_plasma_membrane1.61109535
44MP0001188_hyperpigmentation1.59539884
45MP0005164_abnormal_response_to1.58607389
46MP0000681_abnormal_thyroid_gland1.57572029
47MP0010386_abnormal_urinary_bladder1.56670802
48MP0000767_abnormal_smooth_muscle1.56008913
49MP0001545_abnormal_hematopoietic_system1.55877227
50MP0005397_hematopoietic_system_phenotyp1.55877227
51MP0002733_abnormal_thermal_nociception1.50965374
52MP0005646_abnormal_pituitary_gland1.48142214
53MP0004133_heterotaxia1.45906291
54MP0002067_abnormal_sensory_capabilities1.43847293
55MP0003183_abnormal_peptide_metabolism1.39233046
56MP0006276_abnormal_autonomic_nervous1.37935398
57MP0010368_abnormal_lymphatic_system1.37924548
58MP0001970_abnormal_pain_threshold1.33218321
59MP0009780_abnormal_chondrocyte_physiolo1.33200646
60MP0003942_abnormal_urinary_system1.32911923
61MP0001664_abnormal_digestion1.31060224
62MP0009379_abnormal_foot_pigmentation1.28696554
63MP0004130_abnormal_muscle_cell1.26747672
64MP0005187_abnormal_penis_morphology1.24710383
65MP0002295_abnormal_pulmonary_circulatio1.22913512
66MP0009046_muscle_twitch1.22093342
67MP0001851_eye_inflammation1.20442111
68MP0004215_abnormal_myocardial_fiber1.20103779
69MP0004883_abnormal_blood_vessel1.20003112
70MP0005508_abnormal_skeleton_morphology1.19603055
71MP0002128_abnormal_blood_circulation1.17909816
72MP0003656_abnormal_erythrocyte_physiolo1.15744974
73MP0005671_abnormal_response_to1.15017589
74MP0003787_abnormal_imprinting1.14933063
75MP0002108_abnormal_muscle_morphology1.14835571
76* MP0005620_abnormal_muscle_contractility1.14258070
77MP0002557_abnormal_social/conspecific_i1.12793713
78MP0008775_abnormal_heart_ventricle1.12733353
79MP0001348_abnormal_lacrimal_gland1.11120490
80MP0005075_abnormal_melanosome_morpholog1.10365470
81MP0006138_congestive_heart_failure1.10136061
82MP0004510_myositis1.09538172
83MP0002396_abnormal_hematopoietic_system1.09487802
84MP0010234_abnormal_vibrissa_follicle1.07615273
85MP0004270_analgesia1.07613899
86MP0000343_altered_response_to1.05771036
87MP0005023_abnormal_wound_healing1.05506693
88MP0003879_abnormal_hair_cell1.05011125
89MP0004885_abnormal_endolymph1.04670811
90MP0001485_abnormal_pinna_reflex1.02471606
91MP0001486_abnormal_startle_reflex1.02300119
92MP0001835_abnormal_antigen_presentation1.01837362
93MP0008874_decreased_physiological_sensi1.01736800
94MP0002909_abnormal_adrenal_gland1.00683053
95MP0002734_abnormal_mechanical_nocicepti1.00273065
96MP0006036_abnormal_mitochondrial_physio1.00197475
97MP0000249_abnormal_blood_vessel0.99763317
98MP0002009_preneoplasia0.98969085
99MP0002095_abnormal_skin_pigmentation0.98419544
100MP0005551_abnormal_eye_electrophysiolog0.98212057
101MP0000516_abnormal_urinary_system0.96644309
102MP0005367_renal/urinary_system_phenotyp0.96644309
103MP0000013_abnormal_adipose_tissue0.96641705
104MP0009250_abnormal_appendicular_skeleto0.96432376
105MP0003868_abnormal_feces_composition0.96330981
106MP0002234_abnormal_pharynx_morphology0.95897612
107MP0002938_white_spotting0.94988513
108MP0003119_abnormal_digestive_system0.94909689
109MP0000685_abnormal_immune_system0.94640765
110MP0003075_altered_response_to0.94561730
111MP0005083_abnormal_biliary_tract0.94214292
112MP0004924_abnormal_behavior0.93688892
113MP0005386_behavior/neurological_phenoty0.93688892
114MP0001614_abnormal_blood_vessel0.93669288
115MP0003943_abnormal_hepatobiliary_system0.93531929
116MP0005253_abnormal_eye_physiology0.92214366
117MP0005167_abnormal_blood-brain_barrier0.92062503
118MP0006054_spinal_hemorrhage0.91647038
119MP0003866_abnormal_defecation0.91567831
120MP0008569_lethality_at_weaning0.90050583
121MP0000383_abnormal_hair_follicle0.89885226
122MP0003011_delayed_dark_adaptation0.89825910
123MP0005388_respiratory_system_phenotype0.88445971
124MP0002133_abnormal_respiratory_system0.88445971
125MP0004811_abnormal_neuron_physiology0.88348556
126MP0005085_abnormal_gallbladder_physiolo0.87745662
127MP0002184_abnormal_innervation0.87437861
128MP0001440_abnormal_grooming_behavior0.87378822
129MP0004084_abnormal_cardiac_muscle0.87010363
130MP0001324_abnormal_eye_pigmentation0.86334299
131MP0002928_abnormal_bile_duct0.86049082
132MP0009785_altered_susceptibility_to0.85877101
133MP0006292_abnormal_olfactory_placode0.84240270
134MP0002160_abnormal_reproductive_system0.84125813
135MP0005670_abnormal_white_adipose0.83555188
136MP0006035_abnormal_mitochondrial_morpho0.83533452
137MP0001661_extended_life_span0.83075561
138MP0004085_abnormal_heartbeat0.82407215
139MP0002006_tumorigenesis0.81866999
140MP0008872_abnormal_physiological_respon0.81855365
141MP0003633_abnormal_nervous_system0.81849523
142MP0009765_abnormal_xenobiotic_induced0.79103197
143MP0003724_increased_susceptibility_to0.78942903
144MP0009053_abnormal_anal_canal0.78666933
145MP0000015_abnormal_ear_pigmentation0.78559658
146MP0003638_abnormal_response/metabolism_0.78293943
147MP0005197_abnormal_uvea_morphology0.76047040
148MP0000955_abnormal_spinal_cord0.75592548
149MP0003091_abnormal_cell_migration0.75396521
150MP0003631_nervous_system_phenotype0.75295953
151MP0001984_abnormal_olfaction0.74379798
152MP0002925_abnormal_cardiovascular_devel0.73509710
153MP0005390_skeleton_phenotype0.73024499
154MP0002166_altered_tumor_susceptibility0.70667225
155MP0005408_hypopigmentation0.70433669
156MP0004484_altered_response_of0.70029106
157MP0002115_abnormal_skeleton_extremities0.69522384
158MP0000026_abnormal_inner_ear0.67428253
159MP0000462_abnormal_digestive_system0.67283690
160MP0002398_abnormal_bone_marrow0.67195167
161MP0000049_abnormal_middle_ear0.67023515
162MP0005195_abnormal_posterior_eye0.66931130
163MP0000163_abnormal_cartilage_morphology0.66712439
164MP0000749_muscle_degeneration0.66599621
165MP0005535_abnormal_body_temperature0.63899697
166MP0003283_abnormal_digestive_organ0.63887529
167MP0001879_abnormal_lymphatic_vessel0.63837253
168MP0005423_abnormal_somatic_nervous0.63694302
169MP0005647_abnormal_sex_gland0.63004432
170MP0001765_abnormal_ion_homeostasis0.62986514
171MP0002233_abnormal_nose_morphology0.62612391
172MP0004142_abnormal_muscle_tone0.62547272
173MP0005389_reproductive_system_phenotype0.62267054
174MP0005084_abnormal_gallbladder_morpholo0.61747512
175MP0002075_abnormal_coat/hair_pigmentati0.59663364

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)5.55531055
2Focal motor seizures (HP:0011153)5.36391566
3Thrombocytosis (HP:0001894)5.10541211
4Nonprogressive disorder (HP:0003680)5.08124239
5Prolonged bleeding time (HP:0003010)4.58087643
6Annular pancreas (HP:0001734)4.53295785
7Hypothermia (HP:0002045)4.48810894
8Short hallux (HP:0010109)4.21308800
9Progressive inability to walk (HP:0002505)4.08398832
10Broad metatarsal (HP:0001783)4.07776714
11Aortic aneurysm (HP:0004942)4.06961799
12Purpura (HP:0000979)4.03805489
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.92272793
14Type 2 muscle fiber atrophy (HP:0003554)3.91988709
15Aplasia/Hypoplasia of the hallux (HP:0008362)3.88757023
16Reduced antithrombin III activity (HP:0001976)3.84689199
17Petechiae (HP:0000967)3.79854251
18Aortic dissection (HP:0002647)3.67719813
19Congenital, generalized hypertrichosis (HP:0004540)3.63450504
20Muscle fiber atrophy (HP:0100295)3.53305369
21IgM deficiency (HP:0002850)3.47641040
22Premature rupture of membranes (HP:0001788)3.37443798
23Hypoplastic ischia (HP:0003175)3.36727027
24Spontaneous abortion (HP:0005268)3.32568518
25Abnormality of the ischium (HP:0003174)3.27983465
26Soft skin (HP:0000977)3.26406747
27Febrile seizures (HP:0002373)3.26297599
28Myokymia (HP:0002411)3.22223748
29Type II lissencephaly (HP:0007260)3.21876934
30Pulmonary artery stenosis (HP:0004415)3.20706882
31Gonadotropin excess (HP:0000837)3.20129139
32Ragged-red muscle fibers (HP:0003200)3.19334143
33Increased corneal curvature (HP:0100692)3.12161382
34Keratoconus (HP:0000563)3.12161382
35Impaired platelet aggregation (HP:0003540)3.11986131
36Abnormal platelet function (HP:0011869)3.11986131
37Thyroid-stimulating hormone excess (HP:0002925)3.08823414
38Visual hallucinations (HP:0002367)3.08347809
39Increased IgE level (HP:0003212)3.08328815
40Poor suck (HP:0002033)3.07595672
41Weak cry (HP:0001612)3.05709740
42Chorioretinal atrophy (HP:0000533)2.97336024
43Congenital stationary night blindness (HP:0007642)2.94311207
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85878568
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85878568
46Scotoma (HP:0000575)2.84848869
47Focal seizures (HP:0007359)2.84773404
48Inability to walk (HP:0002540)2.84524851
49Amblyopia (HP:0000646)2.83597782
50Prominent supraorbital ridges (HP:0000336)2.81042493
51Lower limb asymmetry (HP:0100559)2.80965441
52Anterior segment dysgenesis (HP:0007700)2.75298501
53Ulnar claw (HP:0001178)2.74307828
54Hyperlipoproteinemia (HP:0010980)2.70416392
55Epileptic encephalopathy (HP:0200134)2.67434150
56Bone cyst (HP:0012062)2.66677432
57Arterial thrombosis (HP:0004420)2.61589721
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.61174242
59Epistaxis (HP:0000421)2.59653743
60Gaze-evoked nystagmus (HP:0000640)2.55263230
61Mitral stenosis (HP:0001718)2.55221532
62Increased intramyocellular lipid droplets (HP:0012240)2.47555590
63Hemiplegia (HP:0002301)2.46289082
64Menorrhagia (HP:0000132)2.44229518
65Type I transferrin isoform profile (HP:0003642)2.43311275
66Hypoplasia of the iris (HP:0007676)2.42617523
67Hemiparesis (HP:0001269)2.40377209
68Protrusio acetabuli (HP:0003179)2.40117061
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39635090
70Hypoproteinemia (HP:0003075)2.38344955
71Preaxial foot polydactyly (HP:0001841)2.37589912
72Abnormality of midbrain morphology (HP:0002418)2.36396035
73Molar tooth sign on MRI (HP:0002419)2.36396035
74Aplastic anemia (HP:0001915)2.32928281
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32647730
76Abnormal protein N-linked glycosylation (HP:0012347)2.32647730
77Abnormal protein glycosylation (HP:0012346)2.32647730
78Abnormal glycosylation (HP:0012345)2.32647730
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31442707
80Spontaneous hematomas (HP:0007420)2.28957908
81Atonic seizures (HP:0010819)2.27943602
82Blue irides (HP:0000635)2.25928110
83Vertebral arch anomaly (HP:0008438)2.24309226
84Large for gestational age (HP:0001520)2.19885976
85Follicular hyperkeratosis (HP:0007502)2.19867375
86Striae distensae (HP:0001065)2.16307688
87Bladder diverticulum (HP:0000015)2.16282826
88Patchy hypopigmentation of hair (HP:0011365)2.14730071
89Abnormality of the anterior chamber (HP:0000593)2.14716714
90Heterochromia iridis (HP:0001100)2.12691523
91Acute lymphatic leukemia (HP:0006721)2.11687569
92Neoplasm of the heart (HP:0100544)2.10798955
93Neonatal short-limb short stature (HP:0008921)2.10749985
94Palpebral edema (HP:0100540)2.10578649
95Amaurosis fugax (HP:0100576)2.10410986
96Protruding tongue (HP:0010808)2.09909042
97Abnormality of the columella (HP:0009929)2.09728019
98Pancreatic fibrosis (HP:0100732)2.09417878
99Dyskinesia (HP:0100660)2.09031167
100Enlarged penis (HP:0000040)2.05491995
101Aplasia/Hypoplasia of the tibia (HP:0005772)2.03595009
102Aortic valve stenosis (HP:0001650)2.02535692
103Cerebral aneurysm (HP:0004944)2.02272959
104Spinal canal stenosis (HP:0003416)2.01660619
105Abnormal platelet volume (HP:0011876)2.01320701
106Fetal akinesia sequence (HP:0001989)1.99238006
107Metaphyseal dysplasia (HP:0100255)1.99225340
108Decreased central vision (HP:0007663)1.98980927
109Gingival bleeding (HP:0000225)1.98575545
110Vertebral compression fractures (HP:0002953)1.97958900
111Wide anterior fontanel (HP:0000260)1.96631835
112Retinal dysplasia (HP:0007973)1.96216897
113Vascular tortuosity (HP:0004948)1.94691730
114Accelerated skeletal maturation (HP:0005616)1.94057143
115Long nose (HP:0003189)1.93703474
116Zonular cataract (HP:0010920)1.93618701
117Abnormality of the phalanges of the 2nd finger (HP:0009541)1.92914487
118Hyperpituitarism (HP:0010514)1.91900227
119Overgrowth (HP:0001548)1.91892276
120Hyperventilation (HP:0002883)1.91751625
121Syringomyelia (HP:0003396)1.91101281
122Spinal cord lesions (HP:0100561)1.91101281
123Interstitial pulmonary disease (HP:0006530)1.90178711
124Intestinal atresia (HP:0011100)1.89407039
125Abnormality of the renal medulla (HP:0100957)1.88993346
126Peritonitis (HP:0002586)1.88776104
127Short tibia (HP:0005736)1.88768799
128Increased neuronal autofluorescent lipopigment (HP:0002074)1.87995473
129Postural instability (HP:0002172)1.87227254
1303-Methylglutaconic aciduria (HP:0003535)1.86959971
131Depressed nasal tip (HP:0000437)1.85569096
132Broad-based gait (HP:0002136)1.85131731
133Scanning speech (HP:0002168)1.84343856
134Ankle contracture (HP:0006466)1.83552305
135Limb dystonia (HP:0002451)1.83481963
136Tubulointerstitial fibrosis (HP:0005576)1.82524228
137Abnormality of the nasal mucosa (HP:0000433)1.82213364
138Congenital sensorineural hearing impairment (HP:0008527)1.81605115
139Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81517670
140Short 4th metacarpal (HP:0010044)1.81517670
141Hepatocellular necrosis (HP:0001404)1.81345618
142Type 1 muscle fiber predominance (HP:0003803)1.81165945
143Coronal craniosynostosis (HP:0004440)1.81153019
144Pancreatic cysts (HP:0001737)1.81024925
145Abnormality of the neuromuscular junction (HP:0003398)1.79943619
146Fatigable weakness (HP:0003473)1.79943619
147Gingival overgrowth (HP:0000212)1.79813543
148Increased muscle lipid content (HP:0009058)1.78338464
149Bruising susceptibility (HP:0000978)1.78302653
150Hypoventilation (HP:0002791)1.77913008
151Aplasia/Hypoplasia of the fovea (HP:0008060)1.77271628
152Hypoplasia of the fovea (HP:0007750)1.77271628
153Chest pain (HP:0100749)1.76055092
154Venous insufficiency (HP:0005293)1.74624548
155Stereotypic behavior (HP:0000733)1.74170133
156Renal dysplasia (HP:0000110)1.73626948
157Abnormality of the renal collecting system (HP:0004742)1.71417145
158Long toe (HP:0010511)1.71295001
159Abnormal hair whorl (HP:0010721)1.71226992
160Dialeptic seizures (HP:0011146)1.70853103
161Conjunctival telangiectasia (HP:0000524)1.70746605
162Ectopia lentis (HP:0001083)1.70225665
163True hermaphroditism (HP:0010459)1.70002139
164Abnormal number of erythroid precursors (HP:0012131)1.69994868
165Abnormality of cells of the erythroid lineage (HP:0012130)1.67747311
166Bulbous nose (HP:0000414)1.67078353
167Chronic hepatic failure (HP:0100626)1.66615265
168Abnormality of dentin (HP:0010299)1.66613982
169Thyroiditis (HP:0100646)1.64685139
170Nuclear cataract (HP:0100018)1.64263050
171Nephronophthisis (HP:0000090)1.64012324
172Large eyes (HP:0001090)1.63409041
173Shallow orbits (HP:0000586)1.63302181
174Redundant skin (HP:0001582)1.62271486
175Central scotoma (HP:0000603)1.61606181
176Atrophic scars (HP:0001075)1.61299143
177Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.61248659
178Osteoarthritis (HP:0002758)1.60647728
179Aplasia/Hypoplasia of the macula (HP:0008059)1.59388758
180Severe Myopia (HP:0011003)1.59232533
181Decreased skull ossification (HP:0004331)1.58629506
182Papillary thyroid carcinoma (HP:0002895)1.57575536
183Broad hallux (HP:0010055)1.56383134
184Esotropia (HP:0000565)1.55679042
185Chronic otitis media (HP:0000389)1.55264159
186Growth hormone excess (HP:0000845)1.53551858
187Thyroid carcinoma (HP:0002890)1.53041659
188Generalized hypopigmentation of hair (HP:0011358)1.52565163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.92163039
2MAPK153.72348343
3MUSK3.72323980
4NTRK33.68462083
5TIE12.92477366
6EIF2AK12.89211324
7PNCK2.73425058
8CAMKK22.49847457
9PRPF4B2.35016334
10TAF12.32423636
11EPHA42.23323091
12STK392.08763178
13SIK32.05465168
14TNK22.01501777
15NUAK12.01145182
16FRK1.97557656
17DAPK11.94725812
18MKNK11.85722955
19PINK11.83754977
20MST41.81528938
21BMPR1B1.81188519
22EIF2AK31.77929033
23FES1.75864499
24ADRBK11.74711221
25TAOK31.74552960
26STK161.73109413
27MAP3K131.71409457
28CDK191.71087437
29EPHB21.70078062
30NTRK11.64953255
31BRD41.63007141
32MAP3K91.58037116
33PIK3CG1.57895695
34DDR21.57460165
35EPHA31.56383078
36OXSR11.54213420
37CDK81.53972872
38MAP2K61.52756906
39LATS11.51916459
40MAPKAPK51.51257161
41PDGFRB1.43759360
42KSR21.43563553
43MYLK1.37670545
44FGFR31.35970854
45KIT1.35797875
46TXK1.35664350
47STK38L1.35642191
48TNIK1.35235161
49MATK1.33330762
50PAK31.31291339
51ARAF1.27327062
52MAP4K11.27249840
53PAK21.26705637
54TGFBR11.22376270
55MAPK71.20177478
56WEE11.18851704
57CASK1.17494399
58CSNK1G31.12360899
59SYK1.11992249
60BTK1.11663489
61CAMK11.10065269
62CCNB11.08306956
63VRK11.04659400
64RAF11.01607444
65MAP3K21.01295952
66NTRK21.01002318
67KSR11.00615135
68MAP2K31.00323540
69MKNK20.99625008
70MAPKAPK30.96762469
71GRK50.94652713
72STK30.94433778
73TGFBR20.94297482
74GSK3A0.91754206
75ADRBK20.91724035
76MAPK130.91267123
77CSNK1G10.90120554
78JAK30.89916902
79BMX0.89768141
80BRSK20.88433794
81PTK2B0.87559570
82FER0.86816977
83WNK30.86522726
84PRKD10.86271200
85BCKDK0.84659155
86MAP2K70.84614234
87LYN0.83543999
88CSNK1G20.82366056
89MAP4K20.82197102
90CAMKK10.82195192
91NME20.81354962
92ILK0.80536118
93PDK20.78256168
94ROCK10.78194527
95ACVR1B0.74301098
96IRAK10.74158953
97TSSK60.72682884
98DMPK0.72587734
99ABL20.71868818
100PLK20.71850180
101MAP2K40.71377154
102PDGFRA0.70008377
103PDK10.69578432
104PRKD20.69188292
105TEC0.68862396
106HIPK20.68339333
107MAP3K10.66881907
108NEK90.66695473
109LMTK20.65061666
110BMPR20.64200813
111EIF2AK20.64044864
112PRKG20.63952113
113HCK0.63915477
114MAPK120.62715961
115MET0.62373855
116ERBB30.62043770
117MAP2K10.60738240
118DYRK1A0.59696182
119PRKCH0.58721689
120CAMK2A0.57208910
121MARK10.56386244
122* PRKG10.56271713
123MINK10.55632655
124TRPM70.53257829
125PRKCG0.53019602
126DAPK30.51861551
127PRKACA0.51716597
128DYRK20.50845977
129CAMK2B0.50648653
130ZAP700.50360455
131PIK3CA0.49261734
132PKN10.47542095
133PLK30.47216482
134DAPK20.47210607
135CDC42BPA0.46846637
136RPS6KA20.46572152
137STK110.46307364
138DYRK1B0.45106233
139LCK0.44878815
140FGFR20.44386680
141WNK40.44154409
142PRKCA0.43033779
143NME10.42849885
144KDR0.41382623
145RPS6KB10.41208176
146GRK10.40419333
147INSR0.39962414
148PRKCZ0.39723284
149AKT30.39387094
150ABL10.38890426
151MOS0.38673521
152MAPK40.38088980
153YES10.37948988
154CDK30.37866054
155CDK50.35616959
156SGK20.35327964
157RET0.35293893
158CSF1R0.34907743
159GRK60.34502250
160PRKCE0.33499876
161IGF1R0.33432350
162PDPK10.32687099
163FLT30.32600672
164TAOK20.32350148
165PRKACG0.31229570
166MAP3K70.28925835
167CDK90.28861694

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.59156727
2Nicotine addiction_Homo sapiens_hsa050333.83490142
3Long-term potentiation_Homo sapiens_hsa047202.89858511
4Circadian entrainment_Homo sapiens_hsa047132.79561398
5Olfactory transduction_Homo sapiens_hsa047402.66656822
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62853704
7Glutamatergic synapse_Homo sapiens_hsa047242.62449128
8Synaptic vesicle cycle_Homo sapiens_hsa047212.45027212
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.34490169
10Taste transduction_Homo sapiens_hsa047422.21608071
11Amphetamine addiction_Homo sapiens_hsa050312.16605992
12Focal adhesion_Homo sapiens_hsa045102.10840790
13Salivary secretion_Homo sapiens_hsa049702.06944429
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.04196450
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.04163184
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02435240
17GABAergic synapse_Homo sapiens_hsa047271.98280727
18Morphine addiction_Homo sapiens_hsa050321.98124710
19Calcium signaling pathway_Homo sapiens_hsa040201.95973888
20Long-term depression_Homo sapiens_hsa047301.95882453
21Dilated cardiomyopathy_Homo sapiens_hsa054141.94439305
22Nitrogen metabolism_Homo sapiens_hsa009101.91910749
23Serotonergic synapse_Homo sapiens_hsa047261.91223926
24Protein digestion and absorption_Homo sapiens_hsa049741.82656508
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81730147
26Ribosome_Homo sapiens_hsa030101.79881238
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.75945588
28Dopaminergic synapse_Homo sapiens_hsa047281.67491300
29Platelet activation_Homo sapiens_hsa046111.66822927
30Linoleic acid metabolism_Homo sapiens_hsa005911.65234582
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58727204
32Cholinergic synapse_Homo sapiens_hsa047251.51655967
33Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.50810523
34Collecting duct acid secretion_Homo sapiens_hsa049661.48458139
35Sulfur relay system_Homo sapiens_hsa041221.47616339
36Dorso-ventral axis formation_Homo sapiens_hsa043201.47478225
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45788043
38Renin secretion_Homo sapiens_hsa049241.44400509
39Oxytocin signaling pathway_Homo sapiens_hsa049211.39822615
40Phototransduction_Homo sapiens_hsa047441.38496335
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37773148
42Arachidonic acid metabolism_Homo sapiens_hsa005901.32985797
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.31211448
44Cocaine addiction_Homo sapiens_hsa050301.29047396
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28822879
46Insulin secretion_Homo sapiens_hsa049111.28122401
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28101253
48Small cell lung cancer_Homo sapiens_hsa052221.22393043
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20681117
50Gastric acid secretion_Homo sapiens_hsa049711.20074414
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.19005750
52Caffeine metabolism_Homo sapiens_hsa002321.18943104
53African trypanosomiasis_Homo sapiens_hsa051431.11679024
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11402534
55Amoebiasis_Homo sapiens_hsa051461.09003981
56PI3K-Akt signaling pathway_Homo sapiens_hsa041511.08501554
57GnRH signaling pathway_Homo sapiens_hsa049121.06976972
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06757119
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06701512
60Cardiac muscle contraction_Homo sapiens_hsa042601.06386630
61Rheumatoid arthritis_Homo sapiens_hsa053231.05366217
62cAMP signaling pathway_Homo sapiens_hsa040241.02631897
63Vibrio cholerae infection_Homo sapiens_hsa051101.02579672
64Thyroid cancer_Homo sapiens_hsa052161.00942293
65TGF-beta signaling pathway_Homo sapiens_hsa043500.99399358
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98530609
67Pyrimidine metabolism_Homo sapiens_hsa002400.97194468
68Chemical carcinogenesis_Homo sapiens_hsa052040.93366281
69Hematopoietic cell lineage_Homo sapiens_hsa046400.91239551
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91192550
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90850464
72Other glycan degradation_Homo sapiens_hsa005110.90694800
73Gap junction_Homo sapiens_hsa045400.89938880
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87036083
75N-Glycan biosynthesis_Homo sapiens_hsa005100.84787092
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84629286
77Mineral absorption_Homo sapiens_hsa049780.84414481
78Histidine metabolism_Homo sapiens_hsa003400.84346458
79RNA degradation_Homo sapiens_hsa030180.82129728
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.82082690
81Adherens junction_Homo sapiens_hsa045200.81182092
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81000556
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78462211
84Pancreatic secretion_Homo sapiens_hsa049720.77242533
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76632334
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76028179
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75990856
88Sulfur metabolism_Homo sapiens_hsa009200.75519563
89Tryptophan metabolism_Homo sapiens_hsa003800.74922707
90Pathways in cancer_Homo sapiens_hsa052000.74508722
91Glycerolipid metabolism_Homo sapiens_hsa005610.74237288
92Ether lipid metabolism_Homo sapiens_hsa005650.74206260
93Glioma_Homo sapiens_hsa052140.73792424
94Rap1 signaling pathway_Homo sapiens_hsa040150.73282240
95Retinol metabolism_Homo sapiens_hsa008300.71150052
96Purine metabolism_Homo sapiens_hsa002300.70440063
97* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68642102
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67169659
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66618658
100Non-small cell lung cancer_Homo sapiens_hsa052230.66595098
101Selenocompound metabolism_Homo sapiens_hsa004500.66296724
102Melanoma_Homo sapiens_hsa052180.66208105
103Homologous recombination_Homo sapiens_hsa034400.66048244
104Complement and coagulation cascades_Homo sapiens_hsa046100.64263633
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.63128507
106B cell receptor signaling pathway_Homo sapiens_hsa046620.62839444
107Notch signaling pathway_Homo sapiens_hsa043300.60783847
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59908978
109Melanogenesis_Homo sapiens_hsa049160.59845018
110Tight junction_Homo sapiens_hsa045300.58923221
111Basal transcription factors_Homo sapiens_hsa030220.57017931
112Bile secretion_Homo sapiens_hsa049760.56576477
113Ovarian steroidogenesis_Homo sapiens_hsa049130.56541691
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56125809
115Folate biosynthesis_Homo sapiens_hsa007900.55431556
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54200687
117Glucagon signaling pathway_Homo sapiens_hsa049220.53973668
118Hippo signaling pathway_Homo sapiens_hsa043900.53425332
119Galactose metabolism_Homo sapiens_hsa000520.53090949
120Ras signaling pathway_Homo sapiens_hsa040140.53027410
121Basal cell carcinoma_Homo sapiens_hsa052170.52203182
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50706633
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.49851966
124Oocyte meiosis_Homo sapiens_hsa041140.49341670
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48945426
126Proteoglycans in cancer_Homo sapiens_hsa052050.47722040
127Parkinsons disease_Homo sapiens_hsa050120.47373987
128ErbB signaling pathway_Homo sapiens_hsa040120.47234680
129Prolactin signaling pathway_Homo sapiens_hsa049170.46403165
130Thyroid hormone synthesis_Homo sapiens_hsa049180.44483307
131Chemokine signaling pathway_Homo sapiens_hsa040620.42837202
132Acute myeloid leukemia_Homo sapiens_hsa052210.42299562
133Renin-angiotensin system_Homo sapiens_hsa046140.42002644
134Hedgehog signaling pathway_Homo sapiens_hsa043400.41584234
135MAPK signaling pathway_Homo sapiens_hsa040100.40012039
136Estrogen signaling pathway_Homo sapiens_hsa049150.39494373
137Primary immunodeficiency_Homo sapiens_hsa053400.38163756
138ABC transporters_Homo sapiens_hsa020100.37425413
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36418062
140Choline metabolism in cancer_Homo sapiens_hsa052310.36305880
141Sphingolipid metabolism_Homo sapiens_hsa006000.33615455
142Axon guidance_Homo sapiens_hsa043600.32833623
143DNA replication_Homo sapiens_hsa030300.30058954
144Protein export_Homo sapiens_hsa030600.29596137
145Alcoholism_Homo sapiens_hsa050340.29496579
146VEGF signaling pathway_Homo sapiens_hsa043700.28449450
147Alzheimers disease_Homo sapiens_hsa050100.28412930
148Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28338470
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27636202
150Jak-STAT signaling pathway_Homo sapiens_hsa046300.26985152

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