TRPC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)6.60235105
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.58145373
3aminoglycoside antibiotic metabolic process (GO:0030647)6.52779913
4retinal cone cell development (GO:0046549)6.22655868
5acrosome reaction (GO:0007340)5.96552314
6piRNA metabolic process (GO:0034587)5.82977917
7response to pheromone (GO:0019236)5.69286523
8regulation of retinoic acid receptor signaling pathway (GO:0048385)5.65735827
9centriole replication (GO:0007099)5.34005965
10meiotic cell cycle (GO:0051321)5.16881488
11reproduction (GO:0000003)5.06885532
12regulation of female gonad development (GO:2000194)5.03142017
13DNA methylation involved in gamete generation (GO:0043046)5.00934427
14regulation of DNA methylation (GO:0044030)4.85740859
15regulation of meiosis I (GO:0060631)4.85130322
16regulation of acrosome reaction (GO:0060046)4.83090753
17calcium ion-dependent exocytosis (GO:0017156)4.82700185
18sperm motility (GO:0030317)4.68667966
19binding of sperm to zona pellucida (GO:0007339)4.62624550
20vocalization behavior (GO:0071625)4.55439254
21sperm-egg recognition (GO:0035036)4.49355116
22microtubule depolymerization (GO:0007019)4.47790429
23pyrimidine nucleobase catabolic process (GO:0006208)4.46441737
24fusion of sperm to egg plasma membrane (GO:0007342)4.30845114
25auditory receptor cell stereocilium organization (GO:0060088)4.29550622
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.27413481
27microtubule polymerization or depolymerization (GO:0031109)4.16280555
28rRNA methylation (GO:0031167)4.11136799
29male meiosis I (GO:0007141)4.06614364
30chromosome condensation (GO:0030261)4.03542098
31energy homeostasis (GO:0097009)4.02284601
32spermatid development (GO:0007286)3.96640520
33opioid receptor signaling pathway (GO:0038003)3.95264964
34inner ear receptor stereocilium organization (GO:0060122)3.94883473
35microtubule severing (GO:0051013)3.94528262
36protein targeting to Golgi (GO:0000042)3.94232749
37detection of molecule of bacterial origin (GO:0032490)3.93764921
38single strand break repair (GO:0000012)3.86021105
39rRNA modification (GO:0000154)3.84345168
40cellular response to pH (GO:0071467)3.81554139
41spermatid nucleus differentiation (GO:0007289)3.81129302
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.81037365
43neuron cell-cell adhesion (GO:0007158)3.80816418
44regulation of glutamate receptor signaling pathway (GO:1900449)3.77763285
45establishment of protein localization to Golgi (GO:0072600)3.76272107
46synaptic vesicle docking involved in exocytosis (GO:0016081)3.70376494
47centriole assembly (GO:0098534)3.70353630
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.70001656
49cell-cell recognition (GO:0009988)3.69135544
50drinking behavior (GO:0042756)3.66469066
51fertilization (GO:0009566)3.61577854
52protein localization to synapse (GO:0035418)3.60510002
53nucleobase catabolic process (GO:0046113)3.57862107
54DNA packaging (GO:0006323)3.57543443
55spermatogenesis (GO:0007283)3.55764516
56male gamete generation (GO:0048232)3.54395619
57single fertilization (GO:0007338)3.54355472
58postsynaptic membrane organization (GO:0001941)3.53820201
59gamma-aminobutyric acid signaling pathway (GO:0007214)3.53644230
60behavioral response to nicotine (GO:0035095)3.53585146
61cerebral cortex radially oriented cell migration (GO:0021799)3.53187233
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.52875156
63presynaptic membrane organization (GO:0097090)3.50796217
64glutamate receptor signaling pathway (GO:0007215)3.47962450
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.47307415
66sperm capacitation (GO:0048240)3.46883818
67retrograde transport, vesicle recycling within Golgi (GO:0000301)3.46757111
68gamete generation (GO:0007276)3.46702044
69oocyte development (GO:0048599)3.45712784
70positive regulation of histone H3-K4 methylation (GO:0051571)3.45091438
71genitalia morphogenesis (GO:0035112)3.44241372
72startle response (GO:0001964)3.43954365
73female gamete generation (GO:0007292)3.43294616
74regulation of short-term neuronal synaptic plasticity (GO:0048172)3.42442095
75male meiosis (GO:0007140)3.39872730
76synaptic transmission, glutamatergic (GO:0035249)3.39089648
77L-serine transport (GO:0015825)3.31582744
78positive regulation of vesicle fusion (GO:0031340)3.29992103
79negative regulation of synaptic transmission, GABAergic (GO:0032229)3.27542971
80positive regulation of vascular permeability (GO:0043117)3.26901248
81response to acidic pH (GO:0010447)3.26756395
82positive regulation of gastrulation (GO:2000543)3.24217255
83regulation of synaptic vesicle exocytosis (GO:2000300)3.23700628
84synapsis (GO:0007129)3.23395258
85negative regulation of Rho protein signal transduction (GO:0035024)3.22904331
86positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22606180
87regulation of respiratory system process (GO:0044065)3.18110654
88cellular anion homeostasis (GO:0030002)3.17411736
89plasma membrane fusion (GO:0045026)3.16857310
90presynaptic membrane assembly (GO:0097105)3.16090607
91positive regulation of neurotransmitter secretion (GO:0001956)3.15587094
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13434284
93neuron-neuron synaptic transmission (GO:0007270)3.11445051
94neurotransmitter-gated ion channel clustering (GO:0072578)3.11395345
95urinary tract smooth muscle contraction (GO:0014848)3.10284159
96negative regulation of protein autophosphorylation (GO:0031953)3.09154045
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08890640
98regulation of histone H3-K9 methylation (GO:0051570)3.05280864
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05084958
100meiosis I (GO:0007127)3.04584643
101vesicle transport along microtubule (GO:0047496)3.03718644
102negative regulation of reproductive process (GO:2000242)3.02113605
103neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.02033707
104regulation of synaptic vesicle transport (GO:1902803)3.00745202
105germ cell development (GO:0007281)2.99425670
106positive regulation of synapse assembly (GO:0051965)2.98811773
107protein polyglutamylation (GO:0018095)2.97750776
108synaptic vesicle exocytosis (GO:0016079)2.97199063
109gene silencing by RNA (GO:0031047)2.96382321
110regulation of synaptic transmission, glutamatergic (GO:0051966)2.96044734
111prostate gland growth (GO:0060736)2.95193913
112neuron recognition (GO:0008038)2.93902647
113regulation of synapse maturation (GO:0090128)2.92486872
114regulation of respiratory gaseous exchange (GO:0043576)2.91933969
115axonal fasciculation (GO:0007413)2.91862683
116synaptic vesicle endocytosis (GO:0048488)2.89936044
117positive regulation of action potential (GO:0045760)2.89270672
118detection of external biotic stimulus (GO:0098581)2.88349674
119response to histamine (GO:0034776)2.87333848
120negative regulation of histone methylation (GO:0031061)2.84578351
121neuronal ion channel clustering (GO:0045161)2.84427111
122regulation of chromatin silencing (GO:0031935)2.83880662
123transmission of nerve impulse (GO:0019226)2.83432138
124protein localization to Golgi apparatus (GO:0034067)2.82390881
125behavioral response to ethanol (GO:0048149)2.82118380
126establishment of chromosome localization (GO:0051303)2.81478613
127regulation of G0 to G1 transition (GO:0070316)2.80184014
128neuron fate determination (GO:0048664)2.79684500
129retina layer formation (GO:0010842)2.78863117
130atrial cardiac muscle cell action potential (GO:0086014)2.78845350
131oogenesis (GO:0048477)2.77459282
132positive regulation of endothelial cell differentiation (GO:0045603)2.76547056
133negative regulation of Notch signaling pathway (GO:0045746)2.75654973
134mitotic metaphase plate congression (GO:0007080)2.75350691
135regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75116248
136regulation of synaptic transmission, GABAergic (GO:0032228)2.74828005
137learning (GO:0007612)2.73900211
138positive regulation of neurotransmitter transport (GO:0051590)2.73634185
139serotonin receptor signaling pathway (GO:0007210)2.72248061
140attachment of spindle microtubules to kinetochore (GO:0008608)2.70234555
141sulfate transmembrane transport (GO:1902358)2.69124286
142positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.68220718
143regulation of neurotransmitter secretion (GO:0046928)2.67984104
144gene silencing (GO:0016458)2.66501804
145regulation of cell maturation (GO:1903429)2.64816848
146cellular process involved in reproduction in multicellular organism (GO:0022412)2.64199179
147neuronal action potential (GO:0019228)2.63668318
148regulation of calcium ion-dependent exocytosis (GO:0017158)2.63663707
149negative regulation of macroautophagy (GO:0016242)2.63390431
150synaptic transmission, cholinergic (GO:0007271)2.62874904
151motile cilium assembly (GO:0044458)2.62766377
152thrombin receptor signaling pathway (GO:0070493)2.62655226
153aggressive behavior (GO:0002118)2.62401428
154proline transport (GO:0015824)2.62203614
155membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61893065
156regulation of activation of Janus kinase activity (GO:0010533)2.61800263
157extracellular negative regulation of signal transduction (GO:1900116)2.61719135
158extracellular regulation of signal transduction (GO:1900115)2.61719135
159regulation of vesicle fusion (GO:0031338)2.61220697
160histone exchange (GO:0043486)2.61140699
161peristalsis (GO:0030432)2.60514576
162organelle transport along microtubule (GO:0072384)2.59248991
163response to auditory stimulus (GO:0010996)2.59107260
164multicellular organismal reproductive process (GO:0048609)2.58477328
165positive regulation of dendritic spine morphogenesis (GO:0061003)2.57591505
166neurotransmitter secretion (GO:0007269)2.57398461
167serine transport (GO:0032329)2.56560240
168regulation of excitatory postsynaptic membrane potential (GO:0060079)2.56385833
169sialylation (GO:0097503)2.56103401
170regulation of neurotransmitter transport (GO:0051588)2.56043321
171regulation of synapse assembly (GO:0051963)2.54216695
172estrogen biosynthetic process (GO:0006703)2.52640998
173dentate gyrus development (GO:0021542)2.52175641
174cochlea development (GO:0090102)2.52093949
175regulation of postsynaptic membrane potential (GO:0060078)2.51565124
176forebrain neuron differentiation (GO:0021879)2.51012303
177pigment granule localization (GO:0051875)2.49447334
178negative regulation of meiosis (GO:0045835)2.49361550
179lateral ventricle development (GO:0021670)2.49353334
180positive regulation of protein sumoylation (GO:0033235)2.48417602
181synapse assembly (GO:0007416)2.48309879
182neurotransmitter transport (GO:0006836)2.47667176
183long-term memory (GO:0007616)2.47093053
184positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.46399727
185glycine transport (GO:0015816)2.46266720
186regulation of long-term neuronal synaptic plasticity (GO:0048169)2.46040481
187cAMP catabolic process (GO:0006198)2.45076866
188positive regulation of uterine smooth muscle contraction (GO:0070474)2.44119378
189polyketide metabolic process (GO:0030638)10.3466843
190doxorubicin metabolic process (GO:0044598)10.3466843
191daunorubicin metabolic process (GO:0044597)10.3466843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84925698
2GBX2_23144817_ChIP-Seq_PC3_Human4.58576601
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.20910697
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.86288823
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.69270937
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63311183
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62231928
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60228608
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53792588
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49749288
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46117025
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44211483
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.43328687
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.41680079
15ZNF274_21170338_ChIP-Seq_K562_Hela2.37948713
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.36340325
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31131885
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30996532
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23586155
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20043111
21* REST_21632747_ChIP-Seq_MESCs_Mouse2.19948114
22* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14871184
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13002967
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09934762
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09765877
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08772441
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08772441
28P300_19829295_ChIP-Seq_ESCs_Human2.08442003
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06707703
30IGF1R_20145208_ChIP-Seq_DFB_Human2.04299639
31* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96783499
32* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.95604262
33* CBP_20019798_ChIP-Seq_JUKART_Human1.95604262
34TAF15_26573619_Chip-Seq_HEK293_Human1.93980967
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.93857176
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87753011
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86975979
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.86662241
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86274395
40* RNF2_27304074_Chip-Seq_NSC_Mouse1.85788378
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.85608016
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82200622
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82051737
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77869967
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.77332357
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.77144173
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76633869
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74908991
49CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74237717
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74004760
51DROSHA_22980978_ChIP-Seq_HELA_Human1.69414943
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68661649
53* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68178709
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.64363084
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62334758
56AR_21572438_ChIP-Seq_LNCaP_Human1.61130019
57IRF1_19129219_ChIP-ChIP_H3396_Human1.59543084
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59259561
59ER_23166858_ChIP-Seq_MCF-7_Human1.55928180
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55397866
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.53529338
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.53507406
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51720024
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.50701025
65FUS_26573619_Chip-Seq_HEK293_Human1.49814827
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.48581101
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.48397282
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48196855
69P53_22387025_ChIP-Seq_ESCs_Mouse1.44793041
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43302161
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.43301937
72* AR_25329375_ChIP-Seq_VCAP_Human1.42112613
73* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41142956
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39981893
75* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39705020
76* REST_18959480_ChIP-ChIP_MESCs_Mouse1.39069902
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.37827290
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.37597758
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.35877142
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.33127829
81TCF4_23295773_ChIP-Seq_U87_Human1.32948695
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31630463
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31344332
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29857813
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29351234
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.29259172
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28670703
88RUNX2_22187159_ChIP-Seq_PCA_Human1.28507032
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.27842886
90STAT3_23295773_ChIP-Seq_U87_Human1.26284450
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.26126486
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25726524
93NANOG_19829295_ChIP-Seq_ESCs_Human1.25071523
94SOX2_19829295_ChIP-Seq_ESCs_Human1.25071523
95KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24806714
96RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23160234
97AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21273178
98* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20812247
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19941056
100VDR_22108803_ChIP-Seq_LS180_Human1.19567061
101P300_18555785_Chip-Seq_ESCs_Mouse1.19360623
102GATA1_26923725_Chip-Seq_HPCs_Mouse1.19277839
103TBL1_22424771_ChIP-Seq_293T_Human1.18562055
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18137989
105* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17757547
106* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17757547
107JUN_21703547_ChIP-Seq_K562_Human1.17717425
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17258145
109* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17245820
110SMAD4_21741376_ChIP-Seq_HESCs_Human1.15445855
111MYC_19829295_ChIP-Seq_ESCs_Human1.15360450
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13829785
113P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13373344
114RBPJ_21746931_ChIP-Seq_IB4_Human1.12892846
115* NANOG_20526341_ChIP-Seq_ESCs_Human1.12340813
116OCT4_18555785_Chip-Seq_ESCs_Mouse1.12248590
117* SMAD3_21741376_ChIP-Seq_ESCs_Human1.11924877
118ETV1_20927104_ChIP-Seq_GIST48_Human1.11616220
119CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11143597
120TP53_18474530_ChIP-ChIP_U2OS_Human1.11141221
121* EWS_26573619_Chip-Seq_HEK293_Human1.10610102
122PU1_27457419_Chip-Seq_LIVER_Mouse1.10530327
123FOXH1_21741376_ChIP-Seq_EPCs_Human1.10037025
124* TCF4_22108803_ChIP-Seq_LS180_Human1.09411120
125ZFX_18555785_Chip-Seq_ESCs_Mouse1.08947659
126RXR_22108803_ChIP-Seq_LS180_Human1.08773925
127NFYB_21822215_ChIP-Seq_K562_Human1.08732917
128KLF4_18555785_Chip-Seq_ESCs_Mouse1.08596275
129* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08524283
130GF1_26923725_Chip-Seq_HPCs_Mouse1.07431716
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.07215156
132CTCF_18555785_Chip-Seq_ESCs_Mouse1.06662238
133GATA3_21878914_ChIP-Seq_MCF-7_Human1.06530255
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.06431265
135* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06151536
136TP53_22573176_ChIP-Seq_HFKS_Human1.05707857
137TP63_19390658_ChIP-ChIP_HaCaT_Human1.04709217
138NOTCH1_21737748_ChIP-Seq_TLL_Human1.04314240
139PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02525546
140PHF8_20622853_ChIP-Seq_HELA_Human0.99014040
141HOXB7_26014856_ChIP-Seq_BT474_Human0.98801593
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97075449
143* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96209623
144* FLI1_21867929_ChIP-Seq_TH2_Mouse0.95999522
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94188531
146NFYA_21822215_ChIP-Seq_K562_Human0.92923177
147HTT_18923047_ChIP-ChIP_STHdh_Human0.91928019
148CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91647433
149SALL4_22934838_ChIP-ChIP_CD34+_Human0.91113555
150HNFA_21074721_ChIP-Seq_CACO-2_Human0.90990795
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89735913
152BCAT_22108803_ChIP-Seq_LS180_Human0.88487118
153WDR5_24793694_ChIP-Seq_LNCAP_Human0.88305425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage5.66181559
2MP0003718_maternal_effect5.03313430
3MP0003195_calcinosis4.82995803
4MP0005410_abnormal_fertilization4.15501555
5MP0008877_abnormal_DNA_methylation4.05931460
6MP0005423_abnormal_somatic_nervous3.80967917
7MP0005645_abnormal_hypothalamus_physiol3.71763273
8MP0006292_abnormal_olfactory_placode3.37248200
9MP0003880_abnormal_central_pattern3.23347988
10MP0001188_hyperpigmentation3.20128408
11MP0006276_abnormal_autonomic_nervous3.07045377
12MP0009697_abnormal_copulation2.97539537
13MP0004859_abnormal_synaptic_plasticity2.92460469
14MP0005646_abnormal_pituitary_gland2.83970327
15MP0001968_abnormal_touch/_nociception2.77098168
16MP0009745_abnormal_behavioral_response2.66565689
17MP0002735_abnormal_chemical_nociception2.57768389
18MP0009046_muscle_twitch2.54207660
19MP0008004_abnormal_stomach_pH2.45496007
20MP0010386_abnormal_urinary_bladder2.43033348
21MP0003635_abnormal_synaptic_transmissio2.41019067
22MP0001486_abnormal_startle_reflex2.35301908
23MP0003878_abnormal_ear_physiology2.32327101
24MP0005377_hearing/vestibular/ear_phenot2.32327101
25MP0002572_abnormal_emotion/affect_behav2.31076974
26MP0002736_abnormal_nociception_after2.26271327
27MP0005395_other_phenotype2.23219668
28MP0002064_seizures2.22344125
29MP0001929_abnormal_gametogenesis2.19886671
30MP0003879_abnormal_hair_cell2.19799194
31MP0001501_abnormal_sleep_pattern2.18787309
32MP0002272_abnormal_nervous_system2.07740802
33MP0002638_abnormal_pupillary_reflex2.07399262
34MP0002063_abnormal_learning/memory/cond2.00132490
35MP0002734_abnormal_mechanical_nocicepti1.99247826
36MP0002234_abnormal_pharynx_morphology1.96876877
37MP0000566_synostosis1.87777124
38MP0003122_maternal_imprinting1.85741965
39MP0001986_abnormal_taste_sensitivity1.84450911
40MP0003698_abnormal_male_reproductive1.78771465
41MP0005171_absent_coat_pigmentation1.78565184
42MP0002557_abnormal_social/conspecific_i1.74723111
43MP0008260_abnormal_autophagy1.70384806
44MP0001502_abnormal_circadian_rhythm1.69030674
45MP0000678_abnormal_parathyroid_gland1.64248170
46MP0003693_abnormal_embryo_hatching1.62850038
47MP0004742_abnormal_vestibular_system1.60668795
48MP0002822_catalepsy1.60564486
49MP0002184_abnormal_innervation1.56156454
50MP0002067_abnormal_sensory_capabilities1.55073291
51MP0001970_abnormal_pain_threshold1.53794483
52MP0001529_abnormal_vocalization1.52729839
53MP0005386_behavior/neurological_phenoty1.48616468
54MP0004924_abnormal_behavior1.48616468
55MP0004142_abnormal_muscle_tone1.47264386
56MP0001440_abnormal_grooming_behavior1.47246486
57MP0005379_endocrine/exocrine_gland_phen1.47093953
58MP0002876_abnormal_thyroid_physiology1.47042158
59MP0002161_abnormal_fertility/fecundity1.46497632
60MP0002210_abnormal_sex_determination1.44787636
61MP0000778_abnormal_nervous_system1.43737308
62MP0003787_abnormal_imprinting1.41992463
63MP0001905_abnormal_dopamine_level1.41414944
64MP0002733_abnormal_thermal_nociception1.37226096
65MP0001984_abnormal_olfaction1.37212512
66MP0003119_abnormal_digestive_system1.36903886
67MP0002163_abnormal_gland_morphology1.33176574
68MP0010234_abnormal_vibrissa_follicle1.28398866
69MP0001485_abnormal_pinna_reflex1.27852330
70MP0004270_analgesia1.25550275
71MP0000653_abnormal_sex_gland1.21703891
72MP0002653_abnormal_ependyma_morphology1.21050739
73MP0009780_abnormal_chondrocyte_physiolo1.18896625
74MP0000015_abnormal_ear_pigmentation1.16954062
75MP0001963_abnormal_hearing_physiology1.15409402
76MP0000631_abnormal_neuroendocrine_gland1.14344321
77MP0008057_abnormal_DNA_replication1.12198865
78MP0001664_abnormal_digestion1.10930516
79MP0003699_abnormal_female_reproductive1.09820572
80MP0005248_abnormal_Harderian_gland1.09554284
81MP0003077_abnormal_cell_cycle1.07222141
82MP0004147_increased_porphyrin_level1.06920992
83MP0002277_abnormal_respiratory_mucosa1.06472434
84MP0003646_muscle_fatigue1.05057367
85MP0002127_abnormal_cardiovascular_syste1.04695961
86MP0005409_darkened_coat_color1.03987189
87MP0001177_atelectasis1.01652468
88MP0005167_abnormal_blood-brain_barrier1.01223969
89MP0004782_abnormal_surfactant_physiolog1.01099802
90MP0002938_white_spotting0.97673078
91MP0005623_abnormal_meninges_morphology0.97163864
92MP0005551_abnormal_eye_electrophysiolog0.96903206
93MP0001145_abnormal_male_reproductive0.94286319
94MP0000026_abnormal_inner_ear0.92977473
95MP0005360_urolithiasis0.92745685
96MP0002066_abnormal_motor_capabilities/c0.90182687
97MP0005394_taste/olfaction_phenotype0.89908674
98MP0005499_abnormal_olfactory_system0.89908674
99MP0003121_genomic_imprinting0.89555536
100MP0000681_abnormal_thyroid_gland0.89313383
101MP0004484_altered_response_of0.87544169
102MP0009840_abnormal_foam_cell0.86728888
103MP0003724_increased_susceptibility_to0.86616937
104MP0002102_abnormal_ear_morphology0.84371964
105MP0004811_abnormal_neuron_physiology0.83677175
106MP0001293_anophthalmia0.83073577
107MP0002882_abnormal_neuron_morphology0.83022574
108MP0008058_abnormal_DNA_repair0.82602311
109MP0000427_abnormal_hair_cycle0.82331143
110MP0000538_abnormal_urinary_bladder0.81424583
111MP0008569_lethality_at_weaning0.81419830
112MP0002751_abnormal_autonomic_nervous0.75201626
113MP0002160_abnormal_reproductive_system0.75042449
114MP0002132_abnormal_respiratory_system0.73708938
115MP0003631_nervous_system_phenotype0.72727357
116MP0001119_abnormal_female_reproductive0.72383122
117MP0002254_reproductive_system_inflammat0.72251743
118MP0002069_abnormal_eating/drinking_beha0.72009497
119MP0005253_abnormal_eye_physiology0.70524874
120MP0002233_abnormal_nose_morphology0.68697757
121MP0003123_paternal_imprinting0.68514721
122MP0003890_abnormal_embryonic-extraembry0.67986701
123MP0000372_irregular_coat_pigmentation0.67645102
124MP0000465_gastrointestinal_hemorrhage0.67319108
125MP0008789_abnormal_olfactory_epithelium0.67253083
126MP0005647_abnormal_sex_gland0.67098999
127MP0008995_early_reproductive_senescence0.66509008
128MP0005084_abnormal_gallbladder_morpholo0.65482797
129MP0004885_abnormal_endolymph0.65356567
130MP0010368_abnormal_lymphatic_system0.64646461
131MP0002752_abnormal_somatic_nervous0.62697177
132MP0006072_abnormal_retinal_apoptosis0.62388482
133MP0000049_abnormal_middle_ear0.61986453
134MP0002138_abnormal_hepatobiliary_system0.60998139
135MP0003183_abnormal_peptide_metabolism0.60419624
136MP0005535_abnormal_body_temperature0.60292794
137MP0001666_abnormal_nutrient_absorption0.59217102
138MP0000955_abnormal_spinal_cord0.58807607
139MP0004085_abnormal_heartbeat0.55873478
140MP0003633_abnormal_nervous_system0.54980063
141MP0002152_abnormal_brain_morphology0.53787737
142MP0002229_neurodegeneration0.51908014
143MP0003941_abnormal_skin_development0.49540248
144MP0001186_pigmentation_phenotype0.49331867
145MP0008874_decreased_physiological_sensi0.45499747

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.24657785
2Hypophosphatemic rickets (HP:0004912)5.08516367
3Absent/shortened dynein arms (HP:0200106)4.44967223
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.44967223
5Parakeratosis (HP:0001036)4.36343380
6Febrile seizures (HP:0002373)4.05942571
7Bony spicule pigmentary retinopathy (HP:0007737)4.05271828
8Abnormality of dental color (HP:0011073)3.93577708
9Oligodactyly (hands) (HP:0001180)3.90004034
10Absent eyebrow (HP:0002223)3.72600445
11Epileptic encephalopathy (HP:0200134)3.65226328
12Unilateral renal agenesis (HP:0000122)3.62851010
13Supernumerary spleens (HP:0009799)3.61300848
14Attenuation of retinal blood vessels (HP:0007843)3.58524428
15Facial hemangioma (HP:0000329)3.48266736
16Follicular hyperkeratosis (HP:0007502)3.38348442
17Hyperventilation (HP:0002883)3.30818825
18Alopecia of scalp (HP:0002293)3.28317074
19Male infertility (HP:0003251)3.22506366
20Abnormal ciliary motility (HP:0012262)3.18303268
21Broad alveolar ridges (HP:0000187)3.17861194
22Impulsivity (HP:0100710)3.13364530
23Carpal bone hypoplasia (HP:0001498)3.07737276
24Hyperphosphatemia (HP:0002905)3.05075193
25Sensory axonal neuropathy (HP:0003390)3.01800972
26Infertility (HP:0000789)3.00403501
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.95543828
28Abnormal respiratory motile cilium morphology (HP:0005938)2.88999296
29Abnormal respiratory epithelium morphology (HP:0012253)2.88999296
30True hermaphroditism (HP:0010459)2.87781523
31Abnormal hair whorl (HP:0010721)2.85574843
32Atonic seizures (HP:0010819)2.84850628
33Bicornuate uterus (HP:0000813)2.83721939
34Absent eyelashes (HP:0000561)2.80394828
35Anterior segment dysgenesis (HP:0007700)2.79858177
36Progressive cerebellar ataxia (HP:0002073)2.77643749
37Ulnar claw (HP:0001178)2.75704100
38Osteomalacia (HP:0002749)2.74451281
39Nephrogenic diabetes insipidus (HP:0009806)2.72333477
40Recurrent corneal erosions (HP:0000495)2.71370060
41Aplasia/Hypoplasia involving the musculature (HP:0001460)2.69134420
42Abnormality of the fovea (HP:0000493)2.68987187
43Azoospermia (HP:0000027)2.68751678
44Cone-rod dystrophy (HP:0000548)2.66628596
45Broad-based gait (HP:0002136)2.66418615
46Bilateral sensorineural hearing impairment (HP:0008619)2.64522077
47Hypothermia (HP:0002045)2.63981719
48Insidious onset (HP:0003587)2.60046489
49Termporal pattern (HP:0011008)2.60046489
50Chronic hepatic failure (HP:0100626)2.58279882
51Renal dysplasia (HP:0000110)2.57067076
52Gonadotropin excess (HP:0000837)2.56819554
53Abnormality of the labia minora (HP:0012880)2.55942873
54Medial flaring of the eyebrow (HP:0010747)2.55636106
55Focal seizures (HP:0007359)2.53829878
56Abnormal lung lobation (HP:0002101)2.52213601
57Pancreatic fibrosis (HP:0100732)2.52108643
58Myocardial infarction (HP:0001658)2.52070461
59Septo-optic dysplasia (HP:0100842)2.52066719
60Abnormality of macular pigmentation (HP:0008002)2.51200790
61Oligodactyly (HP:0012165)2.49799147
62Molar tooth sign on MRI (HP:0002419)2.48179226
63Abnormality of midbrain morphology (HP:0002418)2.48179226
64Abnormal respiratory motile cilium physiology (HP:0012261)2.45339067
65Abnormality of abdominal situs (HP:0011620)2.44703768
66Abdominal situs inversus (HP:0003363)2.44703768
67Cheilitis (HP:0100825)2.42654591
68Myokymia (HP:0002411)2.40489154
69Fair hair (HP:0002286)2.39552977
70Congenital malformation of the right heart (HP:0011723)2.39220079
71Double outlet right ventricle (HP:0001719)2.39220079
72Protruding tongue (HP:0010808)2.32747627
73Abnormality of the parathyroid morphology (HP:0011766)2.32732280
74Gait imbalance (HP:0002141)2.30680533
75Midline defect of the nose (HP:0004122)2.29789015
76Optic nerve hypoplasia (HP:0000609)2.29340579
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.29133611
78Fetal akinesia sequence (HP:0001989)2.27938074
79Horseshoe kidney (HP:0000085)2.27896328
80Bifid tongue (HP:0010297)2.25855411
81Hyperactive renin-angiotensin system (HP:0000841)2.23735990
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.23407066
83Narrow nasal bridge (HP:0000446)2.21923900
84Aplasia involving forearm bones (HP:0009822)2.20770063
85Absent forearm bone (HP:0003953)2.20770063
86Absent radius (HP:0003974)2.20389205
87Rhinitis (HP:0012384)2.20340828
88Abnormal rod and cone electroretinograms (HP:0008323)2.20289416
89Conjugated hyperbilirubinemia (HP:0002908)2.20096015
90Anophthalmia (HP:0000528)2.18995930
91Abnormality of calcium-phosphate metabolism (HP:0100530)2.18581025
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.18552814
93Hypoplastic pelvis (HP:0008839)2.17284325
94Short tibia (HP:0005736)2.15813757
95Severe visual impairment (HP:0001141)2.15216211
96Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.14924321
97Congenital primary aphakia (HP:0007707)2.14744297
98Absence seizures (HP:0002121)2.13884477
99Dialeptic seizures (HP:0011146)2.13297077
100Decreased circulating renin level (HP:0003351)2.12744945
101Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12700245
102Hypoplasia of the brainstem (HP:0002365)2.12700245
103Absent hair (HP:0002298)2.12541327
104Abnormal spermatogenesis (HP:0008669)2.12528884
105Wrist flexion contracture (HP:0001239)2.12346120
106Intestinal atresia (HP:0011100)2.11838977
107Generalized hypopigmentation of hair (HP:0011358)2.10638147
108Hyperaldosteronism (HP:0000859)2.10416924
109Progressive inability to walk (HP:0002505)2.09711788
110Vascular calcification (HP:0004934)2.08642904
111Generalized tonic-clonic seizures (HP:0002069)2.08600322
112Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08574465
113Type I transferrin isoform profile (HP:0003642)2.07360359
114Pendular nystagmus (HP:0012043)2.06973381
115Hypoglycemic seizures (HP:0002173)2.05147825
116Congenital sensorineural hearing impairment (HP:0008527)2.03864470
117Abolished electroretinogram (ERG) (HP:0000550)2.03452334
118Median cleft lip (HP:0000161)2.03427326
119Nephronophthisis (HP:0000090)2.03028560
120Absent speech (HP:0001344)2.02099544
121Capillary hemangiomas (HP:0005306)2.01648396
122Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.97843963
123Abnormality of incisor morphology (HP:0011063)1.97648278
124Absent septum pellucidum (HP:0001331)1.97338681
125Action tremor (HP:0002345)1.96181365
126Tetany (HP:0001281)1.95199859
127Abnormality of the renal collecting system (HP:0004742)1.94964403
128Alveolar cell carcinoma (HP:0006519)1.94597858
129Abnormality of the septum pellucidum (HP:0007375)1.92951488
130Hip dysplasia (HP:0001385)1.91967400
131Blue irides (HP:0000635)1.91415460
132Widely spaced teeth (HP:0000687)1.90655073
133Poor suck (HP:0002033)1.90522625
134Polyphagia (HP:0002591)1.88009818
135Pancreatic cysts (HP:0001737)1.87779564
136Type 2 muscle fiber atrophy (HP:0003554)1.87471388
137Keratitis (HP:0000491)1.86587478
138Mutism (HP:0002300)1.84611882
139Poor coordination (HP:0002370)1.84465507
140Heterotopia (HP:0002282)1.83677162
141Rickets (HP:0002748)1.83427868
142Urinary urgency (HP:0000012)1.83416054
143Abnormality of renal resorption (HP:0011038)1.80466541
144Aplasia/hypoplasia of the uterus (HP:0008684)1.80422597
145Bradycardia (HP:0001662)1.80402282
146Preaxial hand polydactyly (HP:0001177)1.80324089
147Peripheral hypomyelination (HP:0007182)1.79350297
148Decreased central vision (HP:0007663)1.79034513
149Pachygyria (HP:0001302)1.78493573
150Ectopic kidney (HP:0000086)1.77770421
151Generalized aminoaciduria (HP:0002909)1.77437088
152Duplicated collecting system (HP:0000081)1.77347262
153Inability to walk (HP:0002540)1.77113475
154Photophobia (HP:0000613)1.77079990
155Subcapsular cataract (HP:0000523)1.77038643
156Abnormality of the renal medulla (HP:0100957)1.77020684
157Hypergonadotropic hypogonadism (HP:0000815)1.76885503
158Abnormality of the right ventricle (HP:0001707)1.74881982
159Delayed CNS myelination (HP:0002188)1.74671937
160Lissencephaly (HP:0001339)1.74342630
161Aplasia/Hypoplasia of the macula (HP:0008059)1.74043546
162Chromsome breakage (HP:0040012)1.73711948
163Abnormality of the alveolar ridges (HP:0006477)1.73559388
164Symptomatic seizures (HP:0011145)1.72892036
165Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72609625
166White forelock (HP:0002211)1.72553929
167Aganglionic megacolon (HP:0002251)1.72398854
168Limb dystonia (HP:0002451)1.71559207
169Drooling (HP:0002307)1.70861884
170Excessive salivation (HP:0003781)1.70861884
171Abnormal eating behavior (HP:0100738)1.70143235
172Hypoplasia of the fovea (HP:0007750)1.69312212
173Aplasia/Hypoplasia of the fovea (HP:0008060)1.69312212
174Oligohydramnios (HP:0001562)1.68386131
175Metabolic alkalosis (HP:0200114)1.68357603
176Epileptiform EEG discharges (HP:0011182)1.67953305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.19722722
2PLK44.26896247
3CASK4.02871664
4NTRK33.39758457
5MAP3K123.20785616
6TNIK2.78792848
7INSRR2.74108755
8PRPF4B2.60471116
9MAP2K72.47420119
10SIK22.45108937
11ADRBK22.45075182
12CDK192.33453660
13MAPK132.18672627
14TRIM282.07935128
15OXSR11.98340677
16EPHA41.89300816
17MAP3K91.86884861
18AKT31.71188526
19IRAK31.70639205
20BMPR21.68905684
21EPHA31.64879724
22BRSK21.62847903
23MAP4K21.60551344
24TXK1.58153233
25SGK21.54083202
26TESK11.48627955
27CDK81.47335720
28MARK11.46274432
29TAOK31.45585091
30ZAK1.44894483
31TIE11.44068898
32SIK11.44000709
33MARK31.41462660
34YES11.37049939
35ARAF1.31139683
36IRAK41.28856510
37DDR21.28782187
38BMPR1B1.28110723
39FRK1.26743143
40NTRK21.23288294
41MAP3K41.23162154
42AURKA1.21610001
43TSSK61.19026604
44SGK2231.15479927
45SGK4941.15479927
46STK391.10827981
47PRKCI1.09864989
48CDK121.09013856
49NEK61.07868393
50CDK31.06708093
51STK38L1.05754888
52IRAK11.03815033
53TAOK21.01500130
54GRK10.99933626
55STK160.99693626
56DYRK20.98892861
57CDK90.98625991
58BRSK10.98611682
59PLK20.98037745
60GRK70.96527148
61BRD40.92884422
62MUSK0.90505246
63PLK10.89862450
64FER0.89047035
65MAP3K140.87191980
66KDR0.86482922
67TNK20.86478320
68VRK10.86220118
69CSNK1G10.85238956
70ERBB30.84871727
71PRKCE0.84674664
72MET0.84064081
73ACVR1B0.82838539
74PRKCG0.81627228
75TEC0.78492555
76BRAF0.76842791
77PTK2B0.76005659
78SGK30.72968668
79CAMK2A0.72663993
80MAP2K40.71817479
81MINK10.70772824
82EIF2AK20.68218544
83SRPK10.66727824
84TTK0.66673918
85CDK70.65851270
86GRK50.65163551
87MKNK20.65043683
88CAMK10.63571440
89PINK10.63484230
90SGK10.62747356
91CAMK40.62146128
92CDK50.60829071
93DYRK1A0.58526089
94DAPK10.58480356
95PHKG20.57653407
96PHKG10.57653407
97FES0.57554310
98IRAK20.56514651
99PRKCZ0.54081683
100DAPK20.53323591
101STK380.53027580
102RIPK40.52885833
103RAF10.50731762
104CAMK2B0.50548879
105CCNB10.49583060
106PIK3CG0.49035312
107PAK30.48638689
108ADRBK10.48549452
109CSNK1A1L0.48226014
110NLK0.48127396
111TESK20.47241976
112CHEK10.46564529
113STK240.45946494
114WNK30.45534222
115CSNK1G30.45315908
116DYRK30.43754481
117EIF2AK30.43505334
118PRKG20.42700238
119WNK10.42485174
120CSNK1G20.42465892
121MAP3K60.42231874
122RPS6KB10.41440417
123CDK20.41327630
124PKN10.40896579
125RPS6KA20.40524597
126CAMK1D0.39996587
127MAP3K50.39673632
128MAP3K80.39479547
129MST40.39357033
130PRKACB0.38408232
131KSR10.38317602
132RPS6KC10.38238088
133RPS6KL10.38238088
134CAMK1G0.38114217
135UHMK10.37245221
136AURKB0.35539011
137PRKCQ0.35349495
138BCR0.34817966
139PRKACA0.34704716
140MARK20.34165882
141MAP3K130.34053533
142NUAK10.34004985
143CDC42BPA0.33845555
144PLK30.33742022
145EPHA20.33009079
146BUB10.32957796
147RPS6KA60.32136407
148PRKCA0.31161099
149EGFR0.31120336
150RPS6KA40.31083283
151PRKAA10.30970293
152CSNK1D0.30473360
153* PRKG10.29931090
154CSNK1A10.29894952
155MAPK70.28727417

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.12713276
2Morphine addiction_Homo sapiens_hsa050322.93416554
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90445934
4Synaptic vesicle cycle_Homo sapiens_hsa047212.88808961
5GABAergic synapse_Homo sapiens_hsa047272.74847716
6Taste transduction_Homo sapiens_hsa047422.74615271
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.67798318
8Oocyte meiosis_Homo sapiens_hsa041142.49890599
9Serotonergic synapse_Homo sapiens_hsa047262.46383887
10Circadian entrainment_Homo sapiens_hsa047132.46039561
11Olfactory transduction_Homo sapiens_hsa047402.42982495
12Glutamatergic synapse_Homo sapiens_hsa047242.30582971
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.12861792
14Steroid biosynthesis_Homo sapiens_hsa001002.12309410
15Insulin secretion_Homo sapiens_hsa049112.09206883
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02610612
17Amphetamine addiction_Homo sapiens_hsa050311.98555771
18Dorso-ventral axis formation_Homo sapiens_hsa043201.83010277
19Calcium signaling pathway_Homo sapiens_hsa040201.82967938
20Collecting duct acid secretion_Homo sapiens_hsa049661.77513312
21RNA transport_Homo sapiens_hsa030131.77504610
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.75289575
23Long-term potentiation_Homo sapiens_hsa047201.68916874
24Salivary secretion_Homo sapiens_hsa049701.64760515
25Cocaine addiction_Homo sapiens_hsa050301.63814464
26Long-term depression_Homo sapiens_hsa047301.57866099
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.56776548
28Type I diabetes mellitus_Homo sapiens_hsa049401.52864361
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52547025
30Cholinergic synapse_Homo sapiens_hsa047251.52166732
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.52092182
32Dopaminergic synapse_Homo sapiens_hsa047281.49620795
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43294542
34Renin secretion_Homo sapiens_hsa049241.39326111
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36144152
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34179256
37Cell cycle_Homo sapiens_hsa041101.33474438
38RNA degradation_Homo sapiens_hsa030181.33160148
39Protein export_Homo sapiens_hsa030601.27636917
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23051618
41Rheumatoid arthritis_Homo sapiens_hsa053231.22255504
42Axon guidance_Homo sapiens_hsa043601.17543995
43Gastric acid secretion_Homo sapiens_hsa049711.14598901
44Caffeine metabolism_Homo sapiens_hsa002321.13973751
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07721310
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06879010
47Phototransduction_Homo sapiens_hsa047441.05571621
48Butanoate metabolism_Homo sapiens_hsa006501.04356164
49Vibrio cholerae infection_Homo sapiens_hsa051101.03138769
50Fatty acid biosynthesis_Homo sapiens_hsa000611.01412174
51Ovarian steroidogenesis_Homo sapiens_hsa049131.00713131
52Selenocompound metabolism_Homo sapiens_hsa004500.98383293
53African trypanosomiasis_Homo sapiens_hsa051430.98265515
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97846062
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97241032
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95103753
57Mineral absorption_Homo sapiens_hsa049780.92853311
58Oxytocin signaling pathway_Homo sapiens_hsa049210.90370465
59mRNA surveillance pathway_Homo sapiens_hsa030150.89919926
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88968746
61cAMP signaling pathway_Homo sapiens_hsa040240.88945943
62Oxidative phosphorylation_Homo sapiens_hsa001900.88296000
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87539699
64Type II diabetes mellitus_Homo sapiens_hsa049300.86374185
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85997589
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84435177
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82048676
68Pancreatic secretion_Homo sapiens_hsa049720.80655239
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80364895
70Fatty acid elongation_Homo sapiens_hsa000620.79273423
71Circadian rhythm_Homo sapiens_hsa047100.77369767
72ABC transporters_Homo sapiens_hsa020100.76624746
73RNA polymerase_Homo sapiens_hsa030200.75494594
74Adherens junction_Homo sapiens_hsa045200.75216225
75Sphingolipid metabolism_Homo sapiens_hsa006000.74016213
76Cardiac muscle contraction_Homo sapiens_hsa042600.70572192
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70237421
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.69374053
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.68896319
80Autoimmune thyroid disease_Homo sapiens_hsa053200.68362241
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68018596
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.67633424
83Linoleic acid metabolism_Homo sapiens_hsa005910.67444874
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65658451
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65637453
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65421733
87Alzheimers disease_Homo sapiens_hsa050100.63997053
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.63141243
89Allograft rejection_Homo sapiens_hsa053300.61745019
90Gap junction_Homo sapiens_hsa045400.61612202
91Hedgehog signaling pathway_Homo sapiens_hsa043400.61510501
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60603257
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59139306
94Phagosome_Homo sapiens_hsa041450.58756782
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.58031290
96GnRH signaling pathway_Homo sapiens_hsa049120.56713892
97ErbB signaling pathway_Homo sapiens_hsa040120.56336900
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56041245
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55978792
100Ras signaling pathway_Homo sapiens_hsa040140.55529295
101p53 signaling pathway_Homo sapiens_hsa041150.53270666
102MAPK signaling pathway_Homo sapiens_hsa040100.52551826
103Fanconi anemia pathway_Homo sapiens_hsa034600.52141021
104Parkinsons disease_Homo sapiens_hsa050120.51429209
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50807421
106Bile secretion_Homo sapiens_hsa049760.49011082
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48923979
108Melanoma_Homo sapiens_hsa052180.48524619
109Tight junction_Homo sapiens_hsa045300.48054194
110Huntingtons disease_Homo sapiens_hsa050160.48047593
111Hippo signaling pathway_Homo sapiens_hsa043900.45869195
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45779856
113Arachidonic acid metabolism_Homo sapiens_hsa005900.44349141
114Arginine biosynthesis_Homo sapiens_hsa002200.42663385
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41576651
116Ether lipid metabolism_Homo sapiens_hsa005650.40449780
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40011553
118Wnt signaling pathway_Homo sapiens_hsa043100.39768933
119Estrogen signaling pathway_Homo sapiens_hsa049150.38630223
120Purine metabolism_Homo sapiens_hsa002300.38347826
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36971296
122Dilated cardiomyopathy_Homo sapiens_hsa054140.36548603
123Sulfur metabolism_Homo sapiens_hsa009200.36524522
124Basal transcription factors_Homo sapiens_hsa030220.36202820
125Melanogenesis_Homo sapiens_hsa049160.35965906
126Rap1 signaling pathway_Homo sapiens_hsa040150.35152676
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34082813
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34069255
129N-Glycan biosynthesis_Homo sapiens_hsa005100.33552603
130Starch and sucrose metabolism_Homo sapiens_hsa005000.33544689
131Protein digestion and absorption_Homo sapiens_hsa049740.32719440
132Base excision repair_Homo sapiens_hsa034100.32387684
133Inositol phosphate metabolism_Homo sapiens_hsa005620.32096216
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.32046384
135Endocytosis_Homo sapiens_hsa041440.31620812
136Graft-versus-host disease_Homo sapiens_hsa053320.31208914
137Homologous recombination_Homo sapiens_hsa034400.29545980
138Hematopoietic cell lineage_Homo sapiens_hsa046400.28793315
139Regulation of autophagy_Homo sapiens_hsa041400.28738223
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28390687
141Primary immunodeficiency_Homo sapiens_hsa053400.28128399
142Arginine and proline metabolism_Homo sapiens_hsa003300.22500999
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21187213

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