TRPM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanosome organization (GO:0032438)9.72915395
2pigment granule organization (GO:0048753)9.26716832
3negative regulation of cytosolic calcium ion concentration (GO:0051481)8.78975844
4phenol-containing compound biosynthetic process (GO:0046189)8.61540602
5developmental pigmentation (GO:0048066)8.39621502
6melanocyte differentiation (GO:0030318)8.36512393
7pigment cell differentiation (GO:0050931)8.15956561
8pigment biosynthetic process (GO:0046148)7.78190889
9cellular potassium ion homeostasis (GO:0030007)7.69560344
10melanin biosynthetic process (GO:0042438)7.57823021
11response to pheromone (GO:0019236)7.33608954
12sodium ion export (GO:0071436)6.84749831
13calcium-mediated signaling using intracellular calcium source (GO:0035584)6.83965393
14melanin metabolic process (GO:0006582)6.79809053
15pigment metabolic process (GO:0042440)6.73315481
16ketone body metabolic process (GO:1902224)6.63784274
17potassium ion homeostasis (GO:0055075)6.54679839
18melanosome transport (GO:0032402)6.50645220
19tyrosine metabolic process (GO:0006570)6.47616975
20relaxation of smooth muscle (GO:0044557)6.46232788
21secondary metabolite biosynthetic process (GO:0044550)6.40997992
22retinal cone cell development (GO:0046549)6.34879418
23pigment granule transport (GO:0051904)6.21345226
24establishment of melanosome localization (GO:0032401)6.17362033
25positive regulation of synapse maturation (GO:0090129)6.08925039
26secondary metabolic process (GO:0019748)6.02055473
27* retinal rod cell development (GO:0046548)5.95874960
28establishment of pigment granule localization (GO:0051905)5.90783047
29melanosome localization (GO:0032400)5.90687484
30rhodopsin mediated signaling pathway (GO:0016056)5.82874090
31neuroepithelial cell differentiation (GO:0060563)5.76314872
32pigment granule localization (GO:0051875)5.67301799
33photoreceptor cell maintenance (GO:0045494)5.47579480
34synaptic vesicle endocytosis (GO:0048488)5.24114005
35regulation of rhodopsin mediated signaling pathway (GO:0022400)5.22768572
36cellular response to reactive nitrogen species (GO:1902170)5.20981375
37regulation of integrin-mediated signaling pathway (GO:2001044)5.20758006
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.17593067
39negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)5.07728904
40protein-chromophore linkage (GO:0018298)5.05051148
41response to epinephrine (GO:0071871)5.03828205
42synaptic vesicle exocytosis (GO:0016079)4.98138397
43innervation (GO:0060384)4.95184100
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.91459941
45regulation of synapse maturation (GO:0090128)4.90007213
46protein localization to synapse (GO:0035418)4.86931256
47urinary tract smooth muscle contraction (GO:0014848)4.82979242
48* sensory perception of light stimulus (GO:0050953)4.73318449
49* visual perception (GO:0007601)4.71137038
50gamma-aminobutyric acid signaling pathway (GO:0007214)4.70340964
51* photoreceptor cell development (GO:0042461)4.64070920
52regulation of short-term neuronal synaptic plasticity (GO:0048172)4.60870376
53striatum development (GO:0021756)4.59735721
54negative regulation of interleukin-1 beta production (GO:0032691)4.59266096
55* eye photoreceptor cell development (GO:0042462)4.58923317
56endosome to pigment granule transport (GO:0043485)4.52695400
57endosome to melanosome transport (GO:0035646)4.52695400
58positive regulation of dendritic spine morphogenesis (GO:0061003)4.52681607
59regulation of bile acid biosynthetic process (GO:0070857)4.51251966
60detection of visible light (GO:0009584)4.48969290
61cellular sodium ion homeostasis (GO:0006883)4.39442266
62detection of light stimulus (GO:0009583)4.38424577
63positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.37064506
64pigmentation (GO:0043473)4.36014644
65regulation of superoxide anion generation (GO:0032928)4.31875138
66peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.17467212
67potassium ion export (GO:0071435)4.08721457
68cell communication by electrical coupling (GO:0010644)4.08662276
69nonmotile primary cilium assembly (GO:0035058)4.06950365
70mating behavior (GO:0007617)3.97237652
71regulation of cellular respiration (GO:0043457)3.95818972
72* G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.89689603
73calcium ion import (GO:0070509)3.81030455
74response to muscle activity (GO:0014850)3.78846858
75galactose metabolic process (GO:0006012)3.76021278
76embryonic retina morphogenesis in camera-type eye (GO:0060059)3.75802888
77negative regulation of interleukin-1 production (GO:0032692)3.75499542
78proteasome assembly (GO:0043248)3.75040882
79GMP metabolic process (GO:0046037)3.70943919
80synaptic vesicle maturation (GO:0016188)3.70072460
81cellular response to thyroid hormone stimulus (GO:0097067)3.69680648
82retina development in camera-type eye (GO:0060041)3.66234621
83stress fiber assembly (GO:0043149)3.66147187
84membrane hyperpolarization (GO:0060081)3.63882955
85neurotransmitter-gated ion channel clustering (GO:0072578)3.60037598
86vitamin A metabolic process (GO:0006776)3.59566578
87regulation of synaptic vesicle exocytosis (GO:2000300)3.59541141
88flavonoid metabolic process (GO:0009812)3.58317158
89negative regulation of JUN kinase activity (GO:0043508)3.56410318
90establishment of synaptic vesicle localization (GO:0097480)3.51200719
91synaptic vesicle transport (GO:0048489)3.51200719
92synaptic vesicle docking involved in exocytosis (GO:0016081)3.50439758
93signal peptide processing (GO:0006465)3.46353214
94glycolytic process (GO:0006096)3.46011855
95substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.44913619
96substrate-independent telencephalic tangential migration (GO:0021826)3.44913619
97behavioral response to ethanol (GO:0048149)3.42348508
98phototransduction (GO:0007602)3.41635877
99regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.40452356
100regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.40452356
101phototransduction, visible light (GO:0007603)3.37381555
102positive regulation of cell cycle checkpoint (GO:1901978)3.36551239
103negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.36546147
104negative regulation of acute inflammatory response (GO:0002674)3.35581716
105columnar/cuboidal epithelial cell differentiation (GO:0002065)3.34898389
106natural killer cell activation involved in immune response (GO:0002323)3.34261075
107dentate gyrus development (GO:0021542)3.33110411
108negative regulation of organelle assembly (GO:1902116)3.29123523
109regulation of DNA endoreduplication (GO:0032875)3.28528260
110positive regulation of gastrulation (GO:2000543)3.28382469
111regulation of energy homeostasis (GO:2000505)3.27390947
112positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.20604602
113detection of external stimulus (GO:0009581)3.20417946
114detection of abiotic stimulus (GO:0009582)3.19000782
115regulation of transforming growth factor beta2 production (GO:0032909)3.18744776
116synapse assembly (GO:0007416)3.17819122
117phenol-containing compound metabolic process (GO:0018958)3.17282045
118response to thyroid hormone (GO:0097066)3.16262327
119prepulse inhibition (GO:0060134)3.14517652
120response to histamine (GO:0034776)3.13179326
121regulation of voltage-gated calcium channel activity (GO:1901385)3.11254024
122righting reflex (GO:0060013)3.11065425
123atrial cardiac muscle cell action potential (GO:0086014)3.08279040
124regulation of secondary heart field cardioblast proliferation (GO:0003266)3.06366858
125regulation of cardioblast proliferation (GO:0003264)3.06366858
126axon cargo transport (GO:0008088)3.04291856
127regulation of superoxide metabolic process (GO:0090322)3.03349404
128negative regulation of chemokine production (GO:0032682)3.00857219
129proline transport (GO:0015824)3.00731237
130potassium ion import (GO:0010107)2.98484752
131short-chain fatty acid metabolic process (GO:0046459)2.98012227
132positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.97657026
133inositol phosphate catabolic process (GO:0071545)2.97534637
134calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.97436998
135anterograde axon cargo transport (GO:0008089)2.95863965
136positive regulation of receptor recycling (GO:0001921)2.95446327
137membrane repolarization (GO:0086009)2.94828695
138long term synaptic depression (GO:0060292)2.94074590
139retinal ganglion cell axon guidance (GO:0031290)2.92872921
140positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91305086
141positive regulation vascular endothelial growth factor production (GO:0010575)2.90211359
142membrane depolarization during action potential (GO:0086010)2.88860581
143peristalsis (GO:0030432)2.88797396
144lactate metabolic process (GO:0006089)2.87970237
145nitric oxide mediated signal transduction (GO:0007263)2.87370819
146positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87210437
147regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.86343090
148layer formation in cerebral cortex (GO:0021819)2.85493111
149regulation of synaptic transmission, glutamatergic (GO:0051966)2.84052090
150regulation of early endosome to late endosome transport (GO:2000641)2.82274472
151positive regulation of potassium ion transmembrane transport (GO:1901381)2.81577964
152cerebellar Purkinje cell differentiation (GO:0021702)2.81465722
153vesicle localization (GO:0051648)2.75912384
154regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.69086527
155positive regulation of fatty acid oxidation (GO:0046321)2.65869868
156regulation of sister chromatid cohesion (GO:0007063)2.65050484
157piRNA metabolic process (GO:0034587)2.64131370
158regulation of clathrin-mediated endocytosis (GO:2000369)2.63426182
159negative regulation of TOR signaling (GO:0032007)2.60318827
160positive regulation of gluconeogenesis (GO:0045722)2.58452398
161detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57363781
162mannosylation (GO:0097502)2.54036847
163inositol phosphate dephosphorylation (GO:0046855)2.53560737
164phosphorylated carbohydrate dephosphorylation (GO:0046838)2.53560737
165polyol catabolic process (GO:0046174)2.51289515
166sialylation (GO:0097503)2.51151110
167fusion of sperm to egg plasma membrane (GO:0007342)2.50269194
168positive regulation of protein autophosphorylation (GO:0031954)2.49470876
169synapsis (GO:0007129)2.49013699
170acrosome reaction (GO:0007340)2.48003773
171cullin deneddylation (GO:0010388)2.47286055
172cellular response to nitric oxide (GO:0071732)2.42803999
173mitotic G2 DNA damage checkpoint (GO:0007095)2.42431967
174aromatic amino acid family metabolic process (GO:0009072)2.40980770
175regulation of myelination (GO:0031641)2.40419186
176inner mitochondrial membrane organization (GO:0007007)2.40131093
177osteoclast differentiation (GO:0030316)2.37560469
178glutathione derivative biosynthetic process (GO:1901687)2.34885805
179glutathione derivative metabolic process (GO:1901685)2.34885805
180platelet dense granule organization (GO:0060155)2.34067186
181mitotic G2/M transition checkpoint (GO:0044818)2.31495422
182regulation of sulfur metabolic process (GO:0042762)2.30683747
183intracellular pH reduction (GO:0051452)2.28422915
184gluconeogenesis (GO:0006094)2.26667574
185negative regulation of receptor-mediated endocytosis (GO:0048261)2.25537009
186mitochondrial respiratory chain complex I assembly (GO:0032981)2.24153363
187NADH dehydrogenase complex assembly (GO:0010257)2.24153363
188mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.24153363
189tricarboxylic acid cycle (GO:0006099)2.21814331
190cornea development in camera-type eye (GO:0061303)2.20825950
191kinetochore assembly (GO:0051382)2.19445552
192auditory receptor cell stereocilium organization (GO:0060088)2.18231467
193hexose biosynthetic process (GO:0019319)2.18080539
194negative regulation of receptor activity (GO:2000272)2.16309270
195regulation of glycolytic process (GO:0006110)2.15180282
196detection of light stimulus involved in visual perception (GO:0050908)12.4850525
197detection of light stimulus involved in sensory perception (GO:0050962)12.4850525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat8.32555435
2GBX2_23144817_ChIP-Seq_PC3_Human4.69470360
3E2F7_22180533_ChIP-Seq_HELA_Human4.40634162
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.20412925
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.99253757
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.82590957
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.74432236
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.71615281
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.97219351
10P53_22127205_ChIP-Seq_FIBROBLAST_Human2.79728834
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.69164270
12DROSHA_22980978_ChIP-Seq_HELA_Human2.67935007
13REST_21632747_ChIP-Seq_MESCs_Mouse2.54093355
14TFEB_21752829_ChIP-Seq_HELA_Human2.51377176
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43813950
16* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.36602001
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.36554757
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.26562229
19AR_21572438_ChIP-Seq_LNCaP_Human2.22626803
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20104389
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20068905
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.17320195
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16335188
24VDR_22108803_ChIP-Seq_LS180_Human2.10195941
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.09003030
26JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08783121
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08631549
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08590506
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08318676
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.06314948
31* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01511933
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.01263504
33BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00944282
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00526141
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95175030
36* REST_18959480_ChIP-ChIP_MESCs_Mouse1.92507386
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89157322
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84084667
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83145567
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82878912
41SMAD4_21799915_ChIP-Seq_A2780_Human1.80913523
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.79545008
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76159613
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71942458
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71230295
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70388608
47CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.68597198
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.67666434
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67631831
50FUS_26573619_Chip-Seq_HEK293_Human1.67393782
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66056370
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65903239
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65903239
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65729668
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.65634155
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.63307973
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.61380569
58ELK1_19687146_ChIP-ChIP_HELA_Human1.59306677
59* MITF_21258399_ChIP-Seq_MELANOMA_Human1.56599511
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.56182556
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53598719
62SMAD3_21741376_ChIP-Seq_HESCs_Human1.53357329
63* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.52558131
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.50852329
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.50631182
66* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50156771
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49104684
68STAT3_23295773_ChIP-Seq_U87_Human1.46496922
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45858957
70RNF2_27304074_Chip-Seq_NSC_Mouse1.44504006
71* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43303210
72IGF1R_20145208_ChIP-Seq_DFB_Human1.43116564
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42553241
74AR_25329375_ChIP-Seq_VCAP_Human1.39750426
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39093337
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38691488
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.38209945
78MYC_18940864_ChIP-ChIP_HL60_Human1.37588241
79GATA1_22025678_ChIP-Seq_K562_Human1.36574605
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36032133
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35860976
82* AR_19668381_ChIP-Seq_PC3_Human1.35381857
83P300_19829295_ChIP-Seq_ESCs_Human1.35115344
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34443912
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32873046
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30731001
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28356599
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27623836
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.27292382
90* TCF4_23295773_ChIP-Seq_U87_Human1.26007906
91HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24466792
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23870754
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23006956
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.19594819
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.19405365
96ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19186368
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.19046835
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.18305368
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17994632
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17822933
101EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17545200
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16708247
103FOXP3_21729870_ChIP-Seq_TREG_Human1.16610811
104* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16509749
105SMAD4_21741376_ChIP-Seq_HESCs_Human1.16237331
106* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15472536
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15110844
108ZNF274_21170338_ChIP-Seq_K562_Hela1.14715082
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14312786
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14010954
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13363555
112* SMAD3_21741376_ChIP-Seq_EPCs_Human1.13269266
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11610191
114GABP_19822575_ChIP-Seq_HepG2_Human1.11498474
115KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10156074
116ER_23166858_ChIP-Seq_MCF-7_Human1.09011780
117SOX9_26525672_Chip-Seq_HEART_Mouse1.08864965
118VDR_23849224_ChIP-Seq_CD4+_Human1.08079306
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08069063
120NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.07444634
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07086219
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05993308
123E2F1_21310950_ChIP-Seq_MCF-7_Human1.05163165
124* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05111272
125SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04854794
126TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04487429
127KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04171755
128TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04132847
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03388016
130KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02917758
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.02507858
132ZFX_18555785_Chip-Seq_ESCs_Mouse1.02446676
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02013950
134OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01642494
135* HOXB7_26014856_ChIP-Seq_BT474_Human1.01258784
136SALL1_21062744_ChIP-ChIP_HESCs_Human1.01203654
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00800328
138JUN_21703547_ChIP-Seq_K562_Human1.00782067
139CDX2_22108803_ChIP-Seq_LS180_Human1.00179482
140OCT4_18555785_Chip-Seq_ESCs_Mouse0.98786774
141* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98621689
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98614711
143GATA1_26923725_Chip-Seq_HPCs_Mouse0.98110159
144SOX2_18555785_Chip-Seq_ESCs_Mouse0.97710608
145CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97558037
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97433616
147STAT3_18555785_Chip-Seq_ESCs_Mouse0.97279832
148ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96944437
149NMYC_18555785_Chip-Seq_ESCs_Mouse0.96568708
150SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96217442
151* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95994717
152P53_22387025_ChIP-Seq_ESCs_Mouse0.95750918
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95463167
154LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95332741
155PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95331192
156RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95213918
157ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94885962
158* TCF4_22108803_ChIP-Seq_LS180_Human0.94843877
159BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93945160
160AR_21909140_ChIP-Seq_LNCAP_Human0.93521296
161CTCF_18555785_Chip-Seq_ESCs_Mouse0.92635474
162CBP_21632823_ChIP-Seq_H3396_Human0.92482521
163* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92464262
164TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92182035
165WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92067378
166ARNT_22903824_ChIP-Seq_MCF-7_Human0.91863439
167NANOG_18555785_Chip-Seq_ESCs_Mouse0.91841176
168NFYB_21822215_ChIP-Seq_K562_Human0.90796831
169TP53_20018659_ChIP-ChIP_R1E_Mouse0.90724859
170TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90491117
171TBL1_22424771_ChIP-Seq_293T_Human0.90425677
172TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90291877
173SOX17_20123909_ChIP-Seq_XEN_Mouse0.90147789
174TAF15_26573619_Chip-Seq_HEK293_Human0.90133704
175MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90102862
176CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.90055973
177* CBP_20019798_ChIP-Seq_JUKART_Human0.89454963
178SMAD1_18555785_Chip-Seq_ESCs_Mouse0.88855891
179SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87940051
180CMYC_18555785_Chip-Seq_ESCs_Mouse0.87667888
181KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87658022
182E2F1_18555785_Chip-Seq_ESCs_Mouse0.87406173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog7.25042424
2MP0003011_delayed_dark_adaptation5.83300494
3MP0006072_abnormal_retinal_apoptosis5.31829585
4* MP0005253_abnormal_eye_physiology4.11692570
5MP0000372_irregular_coat_pigmentation3.96793352
6MP0001984_abnormal_olfaction3.94753327
7* MP0002090_abnormal_vision3.65762126
8MP0002877_abnormal_melanocyte_morpholog3.60122045
9MP0003646_muscle_fatigue3.37509329
10MP0005171_absent_coat_pigmentation3.28344990
11MP0001324_abnormal_eye_pigmentation3.22895854
12MP0005174_abnormal_tail_pigmentation2.99425916
13MP0005195_abnormal_posterior_eye2.95754598
14MP0003950_abnormal_plasma_membrane2.83676779
15MP0005248_abnormal_Harderian_gland2.81227402
16MP0006292_abnormal_olfactory_placode2.66792560
17MP0004782_abnormal_surfactant_physiolog2.38379289
18MP0002822_catalepsy2.33978372
19MP0004233_abnormal_muscle_weight2.33672380
20MP0001502_abnormal_circadian_rhythm2.26008871
21MP0002638_abnormal_pupillary_reflex2.19161220
22* MP0005391_vision/eye_phenotype2.02114488
23MP0003136_yellow_coat_color1.95805949
24MP0010386_abnormal_urinary_bladder1.94216623
25MP0002229_neurodegeneration1.86283756
26MP0002938_white_spotting1.83150492
27MP0001346_abnormal_lacrimal_gland1.81029230
28MP0005499_abnormal_olfactory_system1.74830300
29MP0005394_taste/olfaction_phenotype1.74830300
30MP0005257_abnormal_intraocular_pressure1.69300793
31MP0002752_abnormal_somatic_nervous1.69055091
32MP0010030_abnormal_orbit_morphology1.64790878
33MP0005423_abnormal_somatic_nervous1.58793980
34MP0004084_abnormal_cardiac_muscle1.57905481
35MP0010368_abnormal_lymphatic_system1.57465098
36MP0003880_abnormal_central_pattern1.56461183
37MP0000371_diluted_coat_color1.55825938
38MP0008789_abnormal_olfactory_epithelium1.54512986
39MP0009046_muscle_twitch1.54289065
40MP0001486_abnormal_startle_reflex1.53071386
41MP0001188_hyperpigmentation1.49190494
42MP0008775_abnormal_heart_ventricle1.47495108
43MP0004036_abnormal_muscle_relaxation1.42854266
44MP0003806_abnormal_nucleotide_metabolis1.38937221
45MP0002332_abnormal_exercise_endurance1.37854944
46MP0004215_abnormal_myocardial_fiber1.29262361
47MP0004381_abnormal_hair_follicle1.24866181
48MP0002184_abnormal_innervation1.17727271
49MP0002882_abnormal_neuron_morphology1.17067936
50MP0002272_abnormal_nervous_system1.15044811
51MP0000631_abnormal_neuroendocrine_gland1.14688784
52MP0004885_abnormal_endolymph1.13319000
53MP0002067_abnormal_sensory_capabilities1.13072453
54MP0005670_abnormal_white_adipose1.12878400
55MP0010234_abnormal_vibrissa_follicle1.08818474
56MP0003635_abnormal_synaptic_transmissio1.08694094
57MP0002064_seizures1.06552506
58MP0003890_abnormal_embryonic-extraembry1.04681011
59MP0005408_hypopigmentation1.03849620
60MP0002909_abnormal_adrenal_gland1.00646548
61MP0002653_abnormal_ependyma_morphology0.97081393
62MP0005197_abnormal_uvea_morphology0.95107083
63MP0002734_abnormal_mechanical_nocicepti0.93812630
64MP0002075_abnormal_coat/hair_pigmentati0.93299540
65MP0005595_abnormal_vascular_smooth0.90832048
66MP0010094_abnormal_chromosome_stability0.90701075
67MP0000569_abnormal_digit_pigmentation0.89691545
68MP0002102_abnormal_ear_morphology0.87544909
69MP0005075_abnormal_melanosome_morpholog0.85603118
70MP0002063_abnormal_learning/memory/cond0.85064751
71MP0002697_abnormal_eye_size0.83691721
72MP0008569_lethality_at_weaning0.83314264
73MP0003879_abnormal_hair_cell0.81857085
74MP0001968_abnormal_touch/_nociception0.79277748
75MP0005220_abnormal_exocrine_pancreas0.78349095
76MP0002234_abnormal_pharynx_morphology0.77114635
77MP0005409_darkened_coat_color0.76216670
78MP0004043_abnormal_pH_regulation0.73640076
79MP0000015_abnormal_ear_pigmentation0.70504161
80MP0001186_pigmentation_phenotype0.69542693
81MP0004145_abnormal_muscle_electrophysio0.68299345
82MP0001293_anophthalmia0.67548726
83MP0000566_synostosis0.67203218
84MP0003868_abnormal_feces_composition0.66045740
85MP0002095_abnormal_skin_pigmentation0.64383260
86MP0003172_abnormal_lysosome_physiology0.64280157
87MP0004019_abnormal_vitamin_homeostasis0.64154493
88MP0002572_abnormal_emotion/affect_behav0.64025205
89MP0000534_abnormal_ureter_morphology0.63401635
90MP0002177_abnormal_outer_ear0.62820392
91MP0009745_abnormal_behavioral_response0.61867273
92MP0004742_abnormal_vestibular_system0.61817129
93MP0000955_abnormal_spinal_cord0.61681348
94MP0001963_abnormal_hearing_physiology0.60182195
95MP0005187_abnormal_penis_morphology0.59609998
96MP0004924_abnormal_behavior0.59599197
97MP0005386_behavior/neurological_phenoty0.59599197
98MP0004484_altered_response_of0.57017108
99MP0003634_abnormal_glial_cell0.55908507
100MP0004142_abnormal_muscle_tone0.52851770
101MP0000647_abnormal_sebaceous_gland0.52532338
102MP0006138_congestive_heart_failure0.50574438
103MP0000026_abnormal_inner_ear0.50480839
104MP0005620_abnormal_muscle_contractility0.50084694
105MP0006036_abnormal_mitochondrial_physio0.49733535
106MP0000427_abnormal_hair_cycle0.49539025
107MP0002557_abnormal_social/conspecific_i0.49504186
108MP0003137_abnormal_impulse_conducting0.48898410
109MP0002089_abnormal_postnatal_growth/wei0.48348911
110MP0000367_abnormal_coat/_hair0.48206139
111MP0003186_abnormal_redox_activity0.46312979
112MP0006054_spinal_hemorrhage0.45617282
113MP0009697_abnormal_copulation0.45348781
114MP0000749_muscle_degeneration0.45281368
115MP0001485_abnormal_pinna_reflex0.43428186
116MP0005193_abnormal_anterior_eye0.42386694
117MP0001286_abnormal_eye_development0.42036667
118MP0003698_abnormal_male_reproductive0.41454268
119MP0003878_abnormal_ear_physiology0.41091501
120MP0005377_hearing/vestibular/ear_phenot0.41091501
121MP0002751_abnormal_autonomic_nervous0.40665922
122MP0003111_abnormal_nucleus_morphology0.40286672
123MP0005058_abnormal_lysosome_morphology0.38456108
124MP0010678_abnormal_skin_adnexa0.32113801
125MP0003718_maternal_effect0.31297484
126MP0004147_increased_porphyrin_level0.24954903
127MP0000377_abnormal_hair_follicle0.24460097
128MP0000343_altered_response_to0.23986626
129MP0003077_abnormal_cell_cycle0.21254156
130MP0005165_increased_susceptibility_to0.20919342
131MP0008058_abnormal_DNA_repair0.20320867
132MP0002282_abnormal_trachea_morphology0.19978340
133MP0008057_abnormal_DNA_replication0.17502389
134MP0003195_calcinosis0.17013744
135MP0005167_abnormal_blood-brain_barrier0.16378418
136MP0001851_eye_inflammation0.14975022
137MP0001919_abnormal_reproductive_system0.14558141
138MP0009115_abnormal_fat_cell0.11919098
139MP0002837_dystrophic_cardiac_calcinosis0.11761347
140MP0000358_abnormal_cell_content/0.11386275
141MP0002396_abnormal_hematopoietic_system0.11060678
142MP0002269_muscular_atrophy0.10848403
143MP0000920_abnormal_myelination0.10044833
144MP0003943_abnormal_hepatobiliary_system0.09624949
145MP0008932_abnormal_embryonic_tissue0.08004006
146MP0000383_abnormal_hair_follicle0.07734560
147MP0005389_reproductive_system_phenotype0.07364525
148MP0001929_abnormal_gametogenesis0.05736161
149MP0001915_intracranial_hemorrhage0.04839819
150MP0002210_abnormal_sex_determination0.03639025
151MP0002092_abnormal_eye_morphology0.03047729
152MP0008770_decreased_survivor_rate0.01482688
153MP0002161_abnormal_fertility/fecundity0.01379926

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macular pigmentation (HP:0008002)7.82230127
2Central scotoma (HP:0000603)7.76878286
3Abnormal rod and cone electroretinograms (HP:0008323)7.57428151
4Severe visual impairment (HP:0001141)7.45602442
5Patchy hypopigmentation of hair (HP:0011365)7.33898850
6Aplasia/Hypoplasia of the fovea (HP:0008060)6.95676676
7Hypoplasia of the fovea (HP:0007750)6.95676676
8Bony spicule pigmentary retinopathy (HP:0007737)6.60797762
9Abnormality of the fovea (HP:0000493)6.18213764
10Scotoma (HP:0000575)5.95486727
11Keratoconus (HP:0000563)5.78747693
12Increased corneal curvature (HP:0100692)5.78747693
13Aplasia/Hypoplasia of the macula (HP:0008059)5.77847113
14Attenuation of retinal blood vessels (HP:0007843)5.39906999
15Aplasia/Hypoplasia affecting the retina (HP:0008061)5.37175900
16Amblyopia (HP:0000646)5.36627289
17Freckling (HP:0001480)5.32941731
18Septo-optic dysplasia (HP:0100842)5.28586501
19Horizontal nystagmus (HP:0000666)4.73129778
20Absent rod-and cone-mediated responses on ERG (HP:0007688)4.52674248
21Pendular nystagmus (HP:0012043)4.44487452
22Congenital sensorineural hearing impairment (HP:0008527)4.28114973
23Albinism (HP:0001022)4.06303807
24Abolished electroretinogram (ERG) (HP:0000550)3.88109225
25Generalized hypopigmentation of hair (HP:0011358)3.85761035
26Premature graying of hair (HP:0002216)3.81199427
27Cutaneous melanoma (HP:0012056)3.75877358
28* Decreased central vision (HP:0007663)3.66251578
29Heterochromia iridis (HP:0001100)3.58549706
30Abnormal auditory evoked potentials (HP:0006958)3.55864678
31Photophobia (HP:0000613)3.55667739
32Epileptic encephalopathy (HP:0200134)3.53563292
33Aplasia/Hypoplasia affecting the fundus (HP:0008057)3.46525867
34Dyschromatopsia (HP:0007641)3.42877023
35Febrile seizures (HP:0002373)3.41145819
36Generalized hypopigmentation (HP:0007513)3.36375092
37Chorioretinal atrophy (HP:0000533)3.19222971
38Constricted visual fields (HP:0001133)3.14080414
39Absence seizures (HP:0002121)3.04274252
40Type II diabetes mellitus (HP:0005978)3.00554777
41Hypopigmentation of the fundus (HP:0007894)2.98591645
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.93518925
43Bilateral sensorineural hearing impairment (HP:0008619)2.82355059
44Cholecystitis (HP:0001082)2.80696170
45Abnormal gallbladder physiology (HP:0012438)2.80696170
46Pigmentary retinal degeneration (HP:0001146)2.78575079
47Cone-rod dystrophy (HP:0000548)2.77437789
48Blue irides (HP:0000635)2.77410488
49Abnormality of glycolysis (HP:0004366)2.75884468
50Absent septum pellucidum (HP:0001331)2.74131469
51Hypoplasia of the iris (HP:0007676)2.67953149
52Optic nerve hypoplasia (HP:0000609)2.62359601
53Retinitis pigmentosa (HP:0000510)2.58547846
54Choroideremia (HP:0001139)2.57922842
55Macular degeneration (HP:0000608)2.52465702
56Frequent falls (HP:0002359)2.44754633
57Dialeptic seizures (HP:0011146)2.40015209
58Abnormality of the septum pellucidum (HP:0007375)2.36136344
59Degeneration of anterior horn cells (HP:0002398)2.34801110
60Abnormality of the anterior horn cell (HP:0006802)2.34801110
61Ocular albinism (HP:0001107)2.33551878
62Gait imbalance (HP:0002141)2.30940529
63Severe Myopia (HP:0011003)2.25202636
64Congenital primary aphakia (HP:0007707)2.25128165
65Progressive cerebellar ataxia (HP:0002073)2.24113394
66Abdominal situs inversus (HP:0003363)2.23466355
67Abnormality of abdominal situs (HP:0011620)2.23466355
68Prolonged QT interval (HP:0001657)2.19251439
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17126897
70Astigmatism (HP:0000483)2.15662375
71Iris hypopigmentation (HP:0007730)2.11246032
72Hypokinesia (HP:0002375)2.07948076
73Tongue fasciculations (HP:0001308)2.05644466
74Spastic paraparesis (HP:0002313)2.03288833
75Nephrogenic diabetes insipidus (HP:0009806)2.00275228
76* Congenital stationary night blindness (HP:0007642)14.2447456
77Intestinal atresia (HP:0011100)1.96760743
78Hemiparesis (HP:0001269)1.96503975
79Medial flaring of the eyebrow (HP:0010747)1.95672163
80Abnormality of the pupil (HP:0000615)1.91913544
81Acute encephalopathy (HP:0006846)1.90362335
82Poor coordination (HP:0002370)1.87092054
83Increased serum pyruvate (HP:0003542)1.86308914
84Dysdiadochokinesis (HP:0002075)1.82242854
85Growth hormone deficiency (HP:0000824)1.81490112
86Fibular hypoplasia (HP:0003038)1.80393178
87True hermaphroditism (HP:0010459)1.79834262
88Abnormal delayed hypersensitivity skin test (HP:0002963)1.78646508
89Adrenal hypoplasia (HP:0000835)1.76382613
90EEG with generalized epileptiform discharges (HP:0011198)1.76340117
91Epidermoid cyst (HP:0200040)1.75130465
92Chorioretinal coloboma (HP:0000567)1.73931166
93Muscle fibrillation (HP:0010546)1.73781952
94Megalencephaly (HP:0001355)1.71737478
95Spinal muscular atrophy (HP:0007269)1.71498225
96Increased CSF lactate (HP:0002490)1.71186071
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.70762203
98Epileptiform EEG discharges (HP:0011182)1.68002491
99Posterior subcapsular cataract (HP:0007787)1.67137018
100Abnormality of the left ventricular outflow tract (HP:0011103)1.65517113
101Subaortic stenosis (HP:0001682)1.65517113
102Gaze-evoked nystagmus (HP:0000640)1.64801038
103Melanoma (HP:0002861)1.63606033
104Abnormal mitochondria in muscle tissue (HP:0008316)1.61626940
105Acute necrotizing encephalopathy (HP:0006965)1.59671513
106Facial cleft (HP:0002006)1.55575377
107Aplasia/Hypoplasia of the lens (HP:0008063)1.55463095
108Generalized tonic-clonic seizures (HP:0002069)1.54493589
109Genetic anticipation (HP:0003743)1.51103484
110Mutism (HP:0002300)1.50911464
111Visual hallucinations (HP:0002367)1.50662169
112Hepatocellular necrosis (HP:0001404)1.50371980
113Reduced antithrombin III activity (HP:0001976)1.50256690
114Pancreatic cysts (HP:0001737)1.48958315
115Pancreatic fibrosis (HP:0100732)1.48831613
116Progressive macrocephaly (HP:0004481)1.47266586
117Abnormal pupillary function (HP:0007686)1.46065121
118Mitochondrial inheritance (HP:0001427)1.45577028
119Ventricular fibrillation (HP:0001663)1.41745279
120Vaginal atresia (HP:0000148)1.40931869
121Diminished movement (HP:0002374)1.40906174
122Abnormality of the sella turcica (HP:0002679)1.40647445
123Aplasia cutis congenita (HP:0001057)1.39683902
124Genital tract atresia (HP:0001827)1.39180064
125Wide nasal bridge (HP:0000431)1.38146524
126White forelock (HP:0002211)1.37947849
127Abnormal EKG (HP:0003115)1.36929728
128Truncal ataxia (HP:0002078)1.34636291
129Unsteady gait (HP:0002317)1.34302471
130Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.34235522
131Hepatic necrosis (HP:0002605)1.34054076
132Neoplasm of the heart (HP:0100544)1.33749894
133Flat cornea (HP:0007720)1.33288775
134Depression (HP:0000716)1.32404162
135Progressive visual loss (HP:0000529)1.32144051
136Poor head control (HP:0002421)1.31974916
137Volvulus (HP:0002580)1.30844984
138Abnormality of glycolipid metabolism (HP:0010969)1.29525425
139Abnormality of liposaccharide metabolism (HP:0010968)1.29525425
140Abnormality of glycosphingolipid metabolism (HP:0004343)1.29525425
141Renal Fanconi syndrome (HP:0001994)1.29374618
142Optic disc pallor (HP:0000543)1.28064502
143Large for gestational age (HP:0001520)1.24939891
144Abnormality of chromosome stability (HP:0003220)1.23792957
145Arterial tortuosity (HP:0005116)1.23607589
146Subcapsular cataract (HP:0000523)1.23293722
147Syncope (HP:0001279)1.22444227
148Delayed CNS myelination (HP:0002188)1.21711123
149Widely spaced teeth (HP:0000687)1.21682678
150Lipid accumulation in hepatocytes (HP:0006561)1.20376572
151Synophrys (HP:0000664)1.20019594
152Paraparesis (HP:0002385)1.19672683
153Long clavicles (HP:0000890)1.18963164
154Hamartoma of the eye (HP:0010568)1.18938689
155X-linked recessive inheritance (HP:0001419)1.18438398
156Tented upper lip vermilion (HP:0010804)1.18129466
157Type I transferrin isoform profile (HP:0003642)1.17633354
158Esophageal neoplasm (HP:0100751)1.17581608
159Neoplasm of head and neck (HP:0012288)1.17581608
160Optic atrophy (HP:0000648)1.17534811
161Respiratory failure (HP:0002878)1.15020901
162Abnormality of the nasal septum (HP:0000419)1.13392285
163Delayed puberty (HP:0000823)1.10908058
164Cholelithiasis (HP:0001081)1.10872559
165Increased hepatocellular lipid droplets (HP:0006565)1.10808296
166Leukodystrophy (HP:0002415)1.10413281
167Increased intramyocellular lipid droplets (HP:0012240)1.09325899
168Gastrointestinal atresia (HP:0002589)1.08033444
169Aplasia/Hypoplasia of the fibula (HP:0006492)1.07938580
170Lip pit (HP:0100267)1.07194566
171Bifid uvula (HP:0000193)1.06427954
172Hypopigmented skin patches (HP:0001053)1.04293762
173Akinesia (HP:0002304)1.04288110
174Small hand (HP:0200055)1.03070479
175Fatigue (HP:0012378)1.02188040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE15.93036267
2PDK25.25603176
3NEK14.39232512
4MST1R4.22817411
5EIF2AK13.41155804
6BMPR1B3.38436941
7PRPF4B3.34435428
8PBK3.24101652
9TAOK23.13227622
10MAP3K32.87788537
11TRIM282.81635017
12PAK62.71505288
13FRK2.69864356
14PRKCH2.69181078
15STK382.47078129
16GRK12.39674295
17PLK22.38398352
18STK38L2.36478992
19MARK12.21327676
20ACVR1B2.21210235
21SIK32.16474169
22PHKG22.15163482
23PHKG12.15163482
24EPHA31.99823065
25DYRK1A1.96593236
26INSRR1.95831908
27MAP3K41.93578295
28RIPK11.91012288
29CSNK1G31.89198870
30BMX1.88086962
31CSNK1A1L1.74710558
32AKT31.74475564
33EIF2AK31.73264086
34CSNK1G21.71786216
35CDK31.68185184
36MET1.67820704
37MAP3K71.63253023
38TNK21.60601676
39PINK11.48847661
40FGR1.43416942
41CSNK1G11.43396336
42CDC71.41080626
43MARK31.39465011
44MINK11.36183172
45CAMK1D1.33755057
46FES1.33725238
47PTK2B1.29370626
48PRKAA11.24652096
49BRD41.24590092
50FER1.17994766
51NME11.15563676
52GRK61.12923416
53FGFR21.12901886
54CAMK2D1.10720606
55CDK121.07589627
56STK31.06447994
57SGK4941.06216192
58SGK2231.06216192
59DYRK1B1.03369190
60BUB11.01692696
61MAP3K131.01582794
62MAP3K61.01170052
63CASK1.00223948
64CLK10.98906512
65GSK3A0.97979699
66CDK80.97546200
67ERBB30.97280551
68CAMK1G0.96724838
69PAK40.96271029
70SCYL20.96165319
71CHEK20.95861524
72NEK60.95643745
73PRKG20.94008198
74TNIK0.93219175
75BCR0.88200868
76TGFBR20.88074489
77PKN10.87857956
78EPHA40.84945783
79PRKCZ0.84101531
80CAMKK10.82214583
81BMPR20.80866333
82PRKD20.80248609
83IRAK20.75558396
84CAMK10.73816833
85CDK60.73560312
86CDK70.73534630
87CDK90.71265418
88PKN20.71028150
89PLK30.70345799
90PRKD10.69711404
91MAPK100.68701954
92PLK10.68035340
93BRSK10.67119000
94PAK30.66339608
95PRKCE0.66083118
96CSNK1D0.65714902
97SGK20.64918088
98CDK140.63996243
99NME20.63959944
100HIPK20.62901576
101MAPKAPK30.62711670
102GSK3B0.62691060
103TGFBR10.62045674
104MARK20.61807152
105YES10.61037018
106KIT0.60692008
107PRKCB0.58707397
108MAP2K70.58697294
109ATR0.58477077
110PRKCA0.58035628
111EGFR0.57990539
112ERBB20.57438342
113ADRBK10.57310239
114PRKG10.57226516
115NEK20.55767371
116RPS6KA30.55039975
117AKT20.54884717
118GRK50.54427603
119MATK0.53977142
120FGFR10.53737986
121PRKAA20.53325459
122LATS10.53148575
123ATM0.53108137
124CDK150.53054228
125MAP3K90.51993939
126WNK30.51335143
127BCKDK0.50702356
128CAMK40.48751204
129CDC42BPA0.48339152
130CDK180.47995244
131MAPK140.47775483
132PNCK0.47634230
133CCNB10.47434776
134SIK20.45692632
135CDK50.45671094
136ROCK20.45651241
137TYK20.45607312
138CAMK2A0.45288262
139TSSK60.45057166
140CDK11A0.44067816
141PRKCG0.42718494
142ICK0.42421457
143MAPK90.42410896
144PRKACA0.42193968
145MAPK10.41310694
146DDR20.41216145
147TTK0.41019395
148PRKACB0.40907117
149MAPK80.40083351
150MAPK70.39164789
151CDK10.38221387
152CSNK1A10.36646492
153PTK60.30991364
154PLK40.28354248
155BRSK20.28066101
156ABL20.25004751
157CSNK2A10.22565241
158AKT10.20512422
159LMTK20.20398820
160ADRBK20.20170640
161MAP2K10.19886195
162MKNK20.19511987
163MAP4K20.19243003
164STK390.18855746
165EIF2AK20.17740732
166MAPK130.17515559
167CSNK2A20.16232184

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.22684498
2Non-homologous end-joining_Homo sapiens_hsa034504.17587249
3Nicotine addiction_Homo sapiens_hsa050334.08749353
4GABAergic synapse_Homo sapiens_hsa047273.95102067
5Synaptic vesicle cycle_Homo sapiens_hsa047213.84195670
6Proteasome_Homo sapiens_hsa030503.38923324
7Morphine addiction_Homo sapiens_hsa050323.30687752
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.96408534
9Homologous recombination_Homo sapiens_hsa034402.90445711
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.88510664
11Oxidative phosphorylation_Homo sapiens_hsa001902.83143097
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78256580
13Protein export_Homo sapiens_hsa030602.71126970
14Circadian rhythm_Homo sapiens_hsa047102.69266668
15Parkinsons disease_Homo sapiens_hsa050122.62726683
16Olfactory transduction_Homo sapiens_hsa047402.61055927
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.56511844
18Fructose and mannose metabolism_Homo sapiens_hsa000512.32439108
19Circadian entrainment_Homo sapiens_hsa047132.28358025
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.17535887
21Insulin secretion_Homo sapiens_hsa049112.14124413
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.10538725
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08175308
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.92013978
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.92008696
26Salivary secretion_Homo sapiens_hsa049701.86820745
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85141786
28Sphingolipid metabolism_Homo sapiens_hsa006001.81813641
29Renin secretion_Homo sapiens_hsa049241.79764840
30Huntingtons disease_Homo sapiens_hsa050161.77031236
31Glutathione metabolism_Homo sapiens_hsa004801.74869227
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.65039754
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63429900
34Glutamatergic synapse_Homo sapiens_hsa047241.62533459
35Alzheimers disease_Homo sapiens_hsa050101.62180722
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.60875498
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59745671
38Propanoate metabolism_Homo sapiens_hsa006401.57624031
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56833945
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53298160
41Cholinergic synapse_Homo sapiens_hsa047251.51520473
42Cardiac muscle contraction_Homo sapiens_hsa042601.46445961
43Biosynthesis of amino acids_Homo sapiens_hsa012301.45014724
44Oxytocin signaling pathway_Homo sapiens_hsa049211.44998064
45Serotonergic synapse_Homo sapiens_hsa047261.42660870
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.42522158
47Galactose metabolism_Homo sapiens_hsa000521.39106275
48Sulfur metabolism_Homo sapiens_hsa009201.37520640
49Basal transcription factors_Homo sapiens_hsa030221.35944988
50Dilated cardiomyopathy_Homo sapiens_hsa054141.32000571
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28501052
52Mineral absorption_Homo sapiens_hsa049781.25825379
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23977896
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22869551
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22541985
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19425637
57Pentose phosphate pathway_Homo sapiens_hsa000301.17530865
58Dopaminergic synapse_Homo sapiens_hsa047281.16362201
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13827220
60Tyrosine metabolism_Homo sapiens_hsa003501.13178491
61Pyruvate metabolism_Homo sapiens_hsa006201.12950895
62Taste transduction_Homo sapiens_hsa047421.12802058
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12767920
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12338195
65Collecting duct acid secretion_Homo sapiens_hsa049661.11713947
66Butanoate metabolism_Homo sapiens_hsa006501.11418552
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08357637
68One carbon pool by folate_Homo sapiens_hsa006701.06878555
69Fatty acid elongation_Homo sapiens_hsa000621.04801558
70Calcium signaling pathway_Homo sapiens_hsa040200.98675446
71Fatty acid degradation_Homo sapiens_hsa000710.97762799
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97462261
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97432237
74mTOR signaling pathway_Homo sapiens_hsa041500.97001673
75Other glycan degradation_Homo sapiens_hsa005110.94195492
76Mismatch repair_Homo sapiens_hsa034300.93746225
77Inositol phosphate metabolism_Homo sapiens_hsa005620.93424176
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.92876396
79Metabolic pathways_Homo sapiens_hsa011000.92162929
80Cell cycle_Homo sapiens_hsa041100.91435423
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90272820
82Small cell lung cancer_Homo sapiens_hsa052220.88025416
83Chemical carcinogenesis_Homo sapiens_hsa052040.87825039
84p53 signaling pathway_Homo sapiens_hsa041150.87459074
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84965920
86HIF-1 signaling pathway_Homo sapiens_hsa040660.83225672
87RNA transport_Homo sapiens_hsa030130.79417485
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79155769
89Fatty acid metabolism_Homo sapiens_hsa012120.78483735
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77808210
91Gap junction_Homo sapiens_hsa045400.76313378
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75699084
93Nucleotide excision repair_Homo sapiens_hsa034200.75554135
94Prostate cancer_Homo sapiens_hsa052150.74001248
95Retinol metabolism_Homo sapiens_hsa008300.71088576
96Fanconi anemia pathway_Homo sapiens_hsa034600.70925541
97Type II diabetes mellitus_Homo sapiens_hsa049300.69356829
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68855807
99Tryptophan metabolism_Homo sapiens_hsa003800.68247862
100N-Glycan biosynthesis_Homo sapiens_hsa005100.67225152
101Tight junction_Homo sapiens_hsa045300.66652233
102Starch and sucrose metabolism_Homo sapiens_hsa005000.64202538
103Adherens junction_Homo sapiens_hsa045200.63440810
104cAMP signaling pathway_Homo sapiens_hsa040240.63354749
105Folate biosynthesis_Homo sapiens_hsa007900.63343596
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61453301
107Vibrio cholerae infection_Homo sapiens_hsa051100.59853286
108RNA polymerase_Homo sapiens_hsa030200.59841530
109Long-term depression_Homo sapiens_hsa047300.59818554
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59750294
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59567967
112beta-Alanine metabolism_Homo sapiens_hsa004100.57088720
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.56670903
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56443038
115Histidine metabolism_Homo sapiens_hsa003400.53801108
116Melanogenesis_Homo sapiens_hsa049160.53200149
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53000309
118ABC transporters_Homo sapiens_hsa020100.52792811
119Alcoholism_Homo sapiens_hsa050340.51244388
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.50806319
121Pancreatic secretion_Homo sapiens_hsa049720.49706426
122Gastric acid secretion_Homo sapiens_hsa049710.49228857
123Thyroid cancer_Homo sapiens_hsa052160.48967298
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48927997
125Oocyte meiosis_Homo sapiens_hsa041140.47145571
126DNA replication_Homo sapiens_hsa030300.46247926
127Nitrogen metabolism_Homo sapiens_hsa009100.46185915
128Carbon metabolism_Homo sapiens_hsa012000.45104612
129Amphetamine addiction_Homo sapiens_hsa050310.44367585
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43957377
131GnRH signaling pathway_Homo sapiens_hsa049120.43953317
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40168386
133Arginine biosynthesis_Homo sapiens_hsa002200.39521756
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.37620443
135MAPK signaling pathway_Homo sapiens_hsa040100.37503046
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.35838132
137PPAR signaling pathway_Homo sapiens_hsa033200.35729375
138Glycerolipid metabolism_Homo sapiens_hsa005610.33971496
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.33768810
140Fatty acid biosynthesis_Homo sapiens_hsa000610.33765907
141Melanoma_Homo sapiens_hsa052180.33393892
142Peroxisome_Homo sapiens_hsa041460.33068970
143Bile secretion_Homo sapiens_hsa049760.32096203
144Choline metabolism in cancer_Homo sapiens_hsa052310.31820676
145Renal cell carcinoma_Homo sapiens_hsa052110.30382925
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30351296
147ErbB signaling pathway_Homo sapiens_hsa040120.29524064
148Pyrimidine metabolism_Homo sapiens_hsa002400.29440963
149Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27466182
150Glucagon signaling pathway_Homo sapiens_hsa049220.27352968
151Thyroid hormone synthesis_Homo sapiens_hsa049180.26639537
152Arginine and proline metabolism_Homo sapiens_hsa003300.26206988
153AMPK signaling pathway_Homo sapiens_hsa041520.25897813
154Ras signaling pathway_Homo sapiens_hsa040140.24842306
155Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20194805
156Colorectal cancer_Homo sapiens_hsa052100.19906223
157Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19795601
158Glioma_Homo sapiens_hsa052140.19145327
159Long-term potentiation_Homo sapiens_hsa047200.18842570
160Linoleic acid metabolism_Homo sapiens_hsa005910.18655459
161Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18469161
162Purine metabolism_Homo sapiens_hsa002300.18349110
163Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18264384
164SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17708022
165alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17597430
166Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17189824
167RNA degradation_Homo sapiens_hsa030180.16002613
168Axon guidance_Homo sapiens_hsa043600.15863169
169Lysosome_Homo sapiens_hsa041420.15141395
170Wnt signaling pathway_Homo sapiens_hsa043100.15019893
171Protein digestion and absorption_Homo sapiens_hsa049740.13466839
172Lysine degradation_Homo sapiens_hsa003100.12035030

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