TRPM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)5.74131002
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.45530482
3negative regulation of interleukin-12 production (GO:0032695)5.12271171
4macrophage activation involved in immune response (GO:0002281)5.05946549
5neuron cell-cell adhesion (GO:0007158)4.99523735
6neutrophil activation involved in immune response (GO:0002283)4.98135309
7positive regulation of gamma-delta T cell activation (GO:0046645)4.93509277
8central nervous system myelination (GO:0022010)4.82511843
9axon ensheathment in central nervous system (GO:0032291)4.82511843
10modulation by symbiont of host defense response (GO:0052031)4.73083259
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.73083259
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.73083259
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.73083259
14modulation by symbiont of host immune response (GO:0052553)4.73083259
15positive regulation by symbiont of host defense response (GO:0052509)4.73083259
16long-chain fatty acid biosynthetic process (GO:0042759)4.67297661
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.58319296
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.52292074
19ATP synthesis coupled proton transport (GO:0015986)4.52292074
20immunoglobulin mediated immune response (GO:0016064)4.38570849
21protein neddylation (GO:0045116)4.33067481
22transmission of nerve impulse (GO:0019226)4.16028878
23regulation of myeloid leukocyte mediated immunity (GO:0002886)4.14979906
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.10881383
25respiratory electron transport chain (GO:0022904)4.07480518
26chaperone-mediated protein transport (GO:0072321)4.03713099
27negative regulation of erythrocyte differentiation (GO:0045647)3.96165453
28neuronal action potential propagation (GO:0019227)3.96042964
29electron transport chain (GO:0022900)3.95543391
30regulation of mast cell degranulation (GO:0043304)3.94600568
31presynaptic membrane assembly (GO:0097105)3.94559973
32regulation of leukocyte degranulation (GO:0043300)3.91745545
33dopamine transport (GO:0015872)3.91272074
34cellular extravasation (GO:0045123)3.87432283
35neurotransmitter uptake (GO:0001504)3.86779872
36lipopolysaccharide-mediated signaling pathway (GO:0031663)3.86043461
37response to muramyl dipeptide (GO:0032495)3.83794835
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.83460892
39negative regulation of cell killing (GO:0031342)3.83460892
40myeloid cell activation involved in immune response (GO:0002275)3.79204425
41startle response (GO:0001964)3.78645211
42vocalization behavior (GO:0071625)3.75568326
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.73514978
44positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.70958862
45presynaptic membrane organization (GO:0097090)3.70160248
46regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.68293215
47detection of molecule of bacterial origin (GO:0032490)3.65347247
48macrophage activation (GO:0042116)3.65081852
49detection of other organism (GO:0098543)3.64383441
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.61246005
51regulation of mast cell activation involved in immune response (GO:0033006)3.60514732
52positive regulation of mast cell degranulation (GO:0043306)3.59099792
53positive regulation of mast cell activation involved in immune response (GO:0033008)3.59099792
54synaptic vesicle exocytosis (GO:0016079)3.59065550
55regulation of short-term neuronal synaptic plasticity (GO:0048172)3.54284349
56microglial cell activation (GO:0001774)3.53466446
57germinal center formation (GO:0002467)3.52366772
58ionotropic glutamate receptor signaling pathway (GO:0035235)3.50730824
59protein localization to synapse (GO:0035418)3.50571149
60granulocyte activation (GO:0036230)3.48165681
61positive regulation of mast cell activation (GO:0033005)3.44991215
62regulation of gamma-delta T cell activation (GO:0046643)3.44459629
63L-amino acid import (GO:0043092)3.43477832
64detection of bacterium (GO:0016045)3.42864299
65neuron recognition (GO:0008038)3.42112445
66glycosphingolipid catabolic process (GO:0046479)3.38814824
67detection of external biotic stimulus (GO:0098581)3.38798925
68negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38169418
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.36632605
70regulation of regulated secretory pathway (GO:1903305)3.34401962
71regulation of interferon-beta biosynthetic process (GO:0045357)3.30003688
72neutrophil activation (GO:0042119)3.29229948
73cellular response to thyroid hormone stimulus (GO:0097067)3.29039190
74glycerophospholipid catabolic process (GO:0046475)3.28025045
75glutamate receptor signaling pathway (GO:0007215)3.26681980
76respiratory burst (GO:0045730)3.23658611
77T-helper 1 type immune response (GO:0042088)3.23526750
78mannose metabolic process (GO:0006013)3.23464713
79regulation of mast cell activation (GO:0033003)3.23154169
80amino sugar catabolic process (GO:0046348)3.23139535
81interferon-gamma-mediated signaling pathway (GO:0060333)3.22841408
82positive regulation of leukocyte degranulation (GO:0043302)3.22553944
83response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.20499349
84response to host immune response (GO:0052572)3.20499349
85positive regulation of cellular amide metabolic process (GO:0034250)3.19320954
86regulation of glutamate receptor signaling pathway (GO:1900449)3.19277909
87B cell mediated immunity (GO:0019724)3.19138509
88positive regulation of protein homodimerization activity (GO:0090073)3.18957188
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.18083261
90positive regulation of B cell differentiation (GO:0045579)3.17001593
91positive regulation of synapse assembly (GO:0051965)3.15151136
92neuron-neuron synaptic transmission (GO:0007270)3.14391273
93regulation of protein kinase A signaling (GO:0010738)3.13489780
94adenosine receptor signaling pathway (GO:0001973)3.13094403
95negative regulation of granulocyte differentiation (GO:0030853)3.11114944
96positive regulation of antigen processing and presentation (GO:0002579)3.09583682
97regulation of hypersensitivity (GO:0002883)3.08403551
98negative regulation of neurotransmitter transport (GO:0051589)3.07807834
99synaptic transmission, glutamatergic (GO:0035249)3.07430710
100positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.06953260
101response to protozoan (GO:0001562)3.06013170
102fatty acid elongation (GO:0030497)3.05220918
103negative regulation of cytokine production involved in immune response (GO:0002719)3.04411698
104detection of biotic stimulus (GO:0009595)3.04191983
105G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.03146706
106protein complex biogenesis (GO:0070271)3.02806679
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.01620515
108gamma-aminobutyric acid transport (GO:0015812)3.01287154
109glycolipid catabolic process (GO:0019377)3.00624473
110macrophage differentiation (GO:0030225)2.99673758
111regulation of catecholamine metabolic process (GO:0042069)2.99308533
112regulation of dopamine metabolic process (GO:0042053)2.99308533
113N-acetylneuraminate metabolic process (GO:0006054)2.98956783
114regulation of T-helper 2 cell differentiation (GO:0045628)2.97662918
115NIK/NF-kappaB signaling (GO:0038061)2.97429416
116defense response to protozoan (GO:0042832)2.97252464
117regulation of vesicle fusion (GO:0031338)2.96897999
118adult walking behavior (GO:0007628)2.96559080
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95918184
120mitochondrial respiratory chain complex I assembly (GO:0032981)2.95918184
121NADH dehydrogenase complex assembly (GO:0010257)2.95918184
122positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.95395155
123righting reflex (GO:0060013)2.94337688
124phagosome maturation (GO:0090382)2.92567172
125regulation of antigen processing and presentation (GO:0002577)2.90329934
126leukocyte aggregation (GO:0070486)2.90256318
127regulation of vitamin D biosynthetic process (GO:0060556)2.89971324
128positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.88981196
129neuron remodeling (GO:0016322)2.87526723
130ATP hydrolysis coupled proton transport (GO:0015991)2.86919964
131energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.86919964
132response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.86341172
133response to host (GO:0075136)2.86341172
134response to host defenses (GO:0052200)2.86341172
135myeloid dendritic cell activation (GO:0001773)2.86034274
136hydrogen ion transmembrane transport (GO:1902600)2.84475775
137oligosaccharide catabolic process (GO:0009313)2.84390326
138dendritic spine morphogenesis (GO:0060997)2.83503883
139regulation of dendritic cell antigen processing and presentation (GO:0002604)2.83491026
140regulation of B cell receptor signaling pathway (GO:0050855)2.83355966
141regulation of mononuclear cell migration (GO:0071675)2.83318685
142regulation of synaptic vesicle exocytosis (GO:2000300)2.83166573
143myeloid dendritic cell differentiation (GO:0043011)2.82212741
144protein localization to cilium (GO:0061512)2.81155428
145myeloid leukocyte activation (GO:0002274)2.80929888
146regulation of excitatory postsynaptic membrane potential (GO:0060079)2.80917304
147neurotransmitter transport (GO:0006836)2.80300996
148postsynaptic membrane organization (GO:0001941)2.80114128
149substantia nigra development (GO:0021762)2.80046036
150transferrin transport (GO:0033572)2.79378581
151antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79078533
152positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.79035947
153regulation of macrophage chemotaxis (GO:0010758)2.77586341
154catecholamine transport (GO:0051937)2.76237975
155amino acid import (GO:0043090)2.76063595
156regulation of interferon-alpha production (GO:0032647)2.76038365
157GTP biosynthetic process (GO:0006183)2.75797075
158regulation of glutamate secretion (GO:0014048)2.75701418
159regulation of postsynaptic membrane potential (GO:0060078)2.75152008
160negative regulation of protein localization to cell surface (GO:2000009)2.75068293
161regulation of synaptic vesicle transport (GO:1902803)2.74188377
162positive regulation of regulated secretory pathway (GO:1903307)2.73902011
163neutrophil chemotaxis (GO:0030593)2.72723224
164leukocyte degranulation (GO:0043299)2.72398031
165negative regulation of leukocyte mediated immunity (GO:0002704)2.72002552
166positive regulation of membrane potential (GO:0045838)2.71939274
167neuromuscular process controlling posture (GO:0050884)2.71518339
168regulation of superoxide anion generation (GO:0032928)2.70746044
169response to thyroid hormone (GO:0097066)2.70640513
170cellular response to ethanol (GO:0071361)2.69709216
171negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.69705971
172long-term memory (GO:0007616)2.69309032
173regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.68972392
174T cell migration (GO:0072678)2.67574355
175response to histamine (GO:0034776)2.67426946
176mature B cell differentiation involved in immune response (GO:0002313)2.66520514
177behavioral response to cocaine (GO:0048148)2.65763607
178positive regulation of interferon-alpha production (GO:0032727)2.65174883
179neutrophil migration (GO:1990266)2.65017360
180neurotransmitter catabolic process (GO:0042135)2.65013958
181opioid receptor signaling pathway (GO:0038003)2.63907787
182regulation of long-term neuronal synaptic plasticity (GO:0048169)2.63745242
183regulation of neuronal synaptic plasticity (GO:0048168)2.62241326
184proton transport (GO:0015992)2.60075604
185deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.59782192
186regulation of neurotransmitter levels (GO:0001505)2.59278690
187positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58974175
188membrane hyperpolarization (GO:0060081)2.57849919
189mitochondrial respiratory chain complex assembly (GO:0033108)2.56676338
190trivalent inorganic cation transport (GO:0072512)2.56479323
191ferric iron transport (GO:0015682)2.56479323
192synapse assembly (GO:0007416)2.56211134
193neurotransmitter secretion (GO:0007269)2.54929113
194learning (GO:0007612)2.54314625
195neuronal ion channel clustering (GO:0045161)2.54218476
196axonal fasciculation (GO:0007413)2.53952019
197hydrogen transport (GO:0006818)2.53584310
198locomotory exploration behavior (GO:0035641)2.52410705
199mating behavior (GO:0007617)2.50333540
200regulation of respiratory gaseous exchange (GO:0043576)2.49096505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41523318
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.53658938
3VDR_21846776_ChIP-Seq_THP-1_Human3.76206024
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.75207175
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.65922241
6GBX2_23144817_ChIP-Seq_PC3_Human3.53707140
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.30529850
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.27126935
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.16924809
10* VDR_24763502_ChIP-Seq_THP-1_Human3.10746865
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06476642
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83184750
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82705207
14TAF15_26573619_Chip-Seq_HEK293_Human2.77931325
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76922247
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.64999490
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63750402
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.56254033
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54828646
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50366887
21MYC_22102868_ChIP-Seq_BL_Human2.47044503
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46848926
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.46035985
24SPI1_23127762_ChIP-Seq_K562_Human2.41492822
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.39770984
26KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32555263
27BMI1_23680149_ChIP-Seq_NPCS_Mouse2.29779566
28SCL_19346495_ChIP-Seq_HPC-7_Human2.29494640
29LXR_22292898_ChIP-Seq_THP-1_Human2.29068908
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28093942
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27891572
32REST_21632747_ChIP-Seq_MESCs_Mouse2.26500121
33* SPI1_23547873_ChIP-Seq_NB4_Human2.24411788
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21857373
35* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20503710
36* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18438760
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18058454
38BP1_19119308_ChIP-ChIP_Hs578T_Human2.17885560
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16549410
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.14201235
41EED_16625203_ChIP-ChIP_MESCs_Mouse2.11721219
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.07698853
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05200204
44CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05106862
45EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03443573
46RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03443573
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02393567
48CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01646694
49RUNX1_22412390_ChIP-Seq_EML_Mouse2.01328196
50STAT4_19710469_ChIP-ChIP_TH1__Mouse2.01029595
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98972754
52VDR_22108803_ChIP-Seq_LS180_Human1.98067237
53* TCF7_22412390_ChIP-Seq_EML_Mouse1.96497764
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95971206
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94713468
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94187151
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.92390067
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91676971
59KDM2B_26808549_Chip-Seq_DND41_Human1.91548603
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91267111
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89468564
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87863861
63MAF_26560356_Chip-Seq_TH1_Human1.86916821
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85749159
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85406198
66VDR_24787735_ChIP-Seq_THP-1_Human1.84502550
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84235987
68FUS_26573619_Chip-Seq_HEK293_Human1.81428234
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78688227
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77586324
71* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75321278
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.72419973
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.70889414
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.70085358
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69694655
76P300_19829295_ChIP-Seq_ESCs_Human1.67652834
77UTX_26944678_Chip-Seq_JUKART_Human1.66297816
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.62728724
79AR_21572438_ChIP-Seq_LNCaP_Human1.60205387
80ER_23166858_ChIP-Seq_MCF-7_Human1.59458727
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58433693
82RNF2_27304074_Chip-Seq_NSC_Mouse1.58141884
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57603191
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56536275
85IGF1R_20145208_ChIP-Seq_DFB_Human1.55951408
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55725032
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.55129763
88MAF_26560356_Chip-Seq_TH2_Human1.51471555
89* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48674122
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.47995127
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47890143
92RUNX_20019798_ChIP-Seq_JUKART_Human1.47595550
93SMAD4_21799915_ChIP-Seq_A2780_Human1.47098640
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46759241
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46097866
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.44437277
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43712700
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43695565
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.43000190
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.42538976
101MYB_26560356_Chip-Seq_TH2_Human1.40743333
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40458840
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40187459
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40161177
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39454946
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37043640
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36646397
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36315648
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35446857
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34310216
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34293519
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32868245
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32650542
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32250610
115DROSHA_22980978_ChIP-Seq_HELA_Human1.31283287
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30699602
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29543184
118* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29429142
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.27680211
120* PU_27001747_Chip-Seq_BMDM_Mouse1.27011561
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25477514
122* KDM2B_26808549_Chip-Seq_K562_Human1.24996353
123SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24795691
124* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24661832
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.24498403
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24405846
127P300_18555785_Chip-Seq_ESCs_Mouse1.24261771
128* MYB_26560356_Chip-Seq_TH1_Human1.23230392
129POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22261836
130BCOR_27268052_Chip-Seq_Bcells_Human1.21623231
131P53_22387025_ChIP-Seq_ESCs_Mouse1.20872418
132PIAS1_25552417_ChIP-Seq_VCAP_Human1.20805015
133ELF1_20517297_ChIP-Seq_JURKAT_Human1.20450183
134GATA1_19941826_ChIP-Seq_K562_Human1.20444683
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20196248
136BCL6_27268052_Chip-Seq_Bcells_Human1.19875932
137SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19744761
138GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19530935
139RARB_27405468_Chip-Seq_BRAIN_Mouse1.18985433
140NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18553346
141SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18531292
142PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18303859
143MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17894145
144* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17866095
145STAT3_18555785_Chip-Seq_ESCs_Mouse1.17478795
146* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16767763
147SOX2_18555785_Chip-Seq_ESCs_Mouse1.15645136
148RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15143166
149RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14814791
150KDM2B_26808549_Chip-Seq_JURKAT_Human1.14361934
151NMYC_18555785_Chip-Seq_ESCs_Mouse1.14201790
152JUN_21703547_ChIP-Seq_K562_Human1.12805356
153RUNX2_22187159_ChIP-Seq_PCA_Human1.12527433
154KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12332285
155ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12170187
156RACK7_27058665_Chip-Seq_MCF-7_Human1.11761255
157GATA1_22025678_ChIP-Seq_K562_Human1.10804025
158SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10575326
159CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10341520
160SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09358854
161TFEB_21752829_ChIP-Seq_HELA_Human1.09132667
162ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08959650
163HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08484167
164HTT_18923047_ChIP-ChIP_STHdh_Human1.08191717
165TAL1_26923725_Chip-Seq_HPCs_Mouse1.08137142
166SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07652947
167CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07353042
168P68_20966046_ChIP-Seq_HELA_Human1.05413306
169NFE2_27457419_Chip-Seq_LIVER_Mouse1.05266201
170TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04977672
171KLF4_18555785_Chip-Seq_ESCs_Mouse1.03823598
172TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02599275
173SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02469984
174AR_25329375_ChIP-Seq_VCAP_Human1.02247644
175CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02158319
176PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02031379
177ESR2_21235772_ChIP-Seq_MCF-7_Human1.00340460
178TCF4_23295773_ChIP-Seq_U87_Human1.00250849
179EWS_26573619_Chip-Seq_HEK293_Human0.99981572
180ZNF274_21170338_ChIP-Seq_K562_Hela0.98206919
181ZFX_18555785_Chip-Seq_ESCs_Mouse0.97726582
182MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97600395
183MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97400195
184MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96773136
185RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96524457
186STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96500625
187SA1_27219007_Chip-Seq_ERYTHROID_Human0.96359953
188SMC4_20622854_ChIP-Seq_HELA_Human0.96318382
189CTCF_18555785_Chip-Seq_ESCs_Mouse0.96278259
190EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96173402
191* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96043266
192PU1_27457419_Chip-Seq_LIVER_Mouse0.95996206
193P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95745529
194KDM2B_26808549_Chip-Seq_REH_Human0.95468107
195GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95259038
196VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95211476
197NCOR1_26117541_ChIP-Seq_K562_Human0.95089647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.02201804
2MP0003303_peritoneal_inflammation4.17403044
3MP0005058_abnormal_lysosome_morphology4.04387166
4MP0003436_decreased_susceptibility_to3.63961272
5MP0001529_abnormal_vocalization3.50075081
6MP0004859_abnormal_synaptic_plasticity3.42813170
7MP0003172_abnormal_lysosome_physiology3.22002814
8MP0001835_abnormal_antigen_presentation3.21984689
9MP0009745_abnormal_behavioral_response3.18514116
10MP0003635_abnormal_synaptic_transmissio3.13848304
11MP0006082_CNS_inflammation3.10349180
12MP0002064_seizures3.09627730
13* MP0002419_abnormal_innate_immunity3.01543523
14MP0009046_muscle_twitch3.01283904
15MP0004270_analgesia2.92527414
16MP0002272_abnormal_nervous_system2.84207578
17MP0009278_abnormal_bone_marrow2.81424430
18MP0002148_abnormal_hypersensitivity_rea2.77712011
19MP0003724_increased_susceptibility_to2.75946035
20MP0009785_altered_susceptibility_to2.75566228
21MP0006276_abnormal_autonomic_nervous2.68365609
22MP0001968_abnormal_touch/_nociception2.65803678
23MP0001486_abnormal_startle_reflex2.65016992
24MP0005025_abnormal_response_to2.63692997
25MP0005671_abnormal_response_to2.63405474
26MP0005423_abnormal_somatic_nervous2.61070535
27MP0002572_abnormal_emotion/affect_behav2.58834441
28MP0005000_abnormal_immune_tolerance2.56494405
29MP0005387_immune_system_phenotype2.50737790
30MP0001790_abnormal_immune_system2.50737790
31MP0001905_abnormal_dopamine_level2.50091118
32MP0005409_darkened_coat_color2.49139006
33MP0003300_gastrointestinal_ulcer2.47565773
34MP0009840_abnormal_foam_cell2.47393816
35MP0002063_abnormal_learning/memory/cond2.45075466
36MP0000685_abnormal_immune_system2.43887722
37MP0001440_abnormal_grooming_behavior2.41708848
38MP0004142_abnormal_muscle_tone2.37352710
39MP0002734_abnormal_mechanical_nocicepti2.37044529
40MP0002736_abnormal_nociception_after2.33086799
41MP0001501_abnormal_sleep_pattern2.26909574
42MP0003075_altered_response_to2.24999211
43* MP0002452_abnormal_antigen_presenting2.22550468
44MP0001800_abnormal_humoral_immune2.20502062
45* MP0002723_abnormal_immune_serum2.17516620
46MP0005451_abnormal_body_composition2.15231362
47MP0001970_abnormal_pain_threshold2.04213847
48MP0004510_myositis2.03431004
49MP0005464_abnormal_platelet_physiology2.02426103
50* MP0002420_abnormal_adaptive_immunity2.02194405
51MP0005645_abnormal_hypothalamus_physiol2.02131568
52* MP0001819_abnormal_immune_cell2.01427572
53MP0000920_abnormal_myelination1.97594889
54MP0003191_abnormal_cellular_cholesterol1.97382202
55MP0001545_abnormal_hematopoietic_system1.97235787
56MP0005397_hematopoietic_system_phenotyp1.97235787
57MP0001533_abnormal_skeleton_physiology1.94602682
58MP0002735_abnormal_chemical_nociception1.90740692
59MP0002067_abnormal_sensory_capabilities1.88986729
60MP0002733_abnormal_thermal_nociception1.85161535
61MP0004742_abnormal_vestibular_system1.81751636
62MP0005171_absent_coat_pigmentation1.81488313
63MP0004947_skin_inflammation1.77832716
64MP0000343_altered_response_to1.76167195
65MP0001188_hyperpigmentation1.74121661
66MP0000778_abnormal_nervous_system1.72187116
67MP0002998_abnormal_bone_remodeling1.70193485
68MP0004924_abnormal_behavior1.68526860
69MP0005386_behavior/neurological_phenoty1.68526860
70MP0001853_heart_inflammation1.64426539
71MP0008057_abnormal_DNA_replication1.61690377
72* MP0001845_abnormal_inflammatory_respons1.61548646
73MP0002184_abnormal_innervation1.60711180
74MP0002405_respiratory_system_inflammati1.59872570
75MP0005310_abnormal_salivary_gland1.59868878
76MP0003136_yellow_coat_color1.58736102
77MP0009764_decreased_sensitivity_to1.54738960
78MP0002557_abnormal_social/conspecific_i1.53509968
79MP0010155_abnormal_intestine_physiology1.51973365
80MP0003122_maternal_imprinting1.51731569
81MP0000716_abnormal_immune_system1.49151591
82* MP0008469_abnormal_protein_level1.46269242
83MP0002822_catalepsy1.45534226
84MP0003329_amyloid_beta_deposits1.41887117
85MP0005167_abnormal_blood-brain_barrier1.39385349
86MP0002398_abnormal_bone_marrow1.37441669
87MP0000858_altered_metastatic_potential1.37206194
88MP0003828_pulmonary_edema1.33093337
89MP0001984_abnormal_olfaction1.32024957
90MP0005166_decreased_susceptibility_to1.31012048
91MP0003690_abnormal_glial_cell1.30049331
92MP0009333_abnormal_splenocyte_physiolog1.29997324
93MP0002066_abnormal_motor_capabilities/c1.28561500
94MP0003806_abnormal_nucleotide_metabolis1.28351902
95MP0002837_dystrophic_cardiac_calcinosis1.26787350
96MP0002882_abnormal_neuron_morphology1.25318040
97MP0000015_abnormal_ear_pigmentation1.25282097
98MP0005551_abnormal_eye_electrophysiolog1.24146407
99MP0009379_abnormal_foot_pigmentation1.24107484
100MP0008569_lethality_at_weaning1.23840140
101MP0000689_abnormal_spleen_morphology1.21674643
102MP0003448_altered_tumor_morphology1.19878545
103MP0000955_abnormal_spinal_cord1.19443540
104MP0001485_abnormal_pinna_reflex1.19363026
105MP0001986_abnormal_taste_sensitivity1.18114039
106MP0010386_abnormal_urinary_bladder1.17897580
107MP0002429_abnormal_blood_cell1.17533541
108MP0001963_abnormal_hearing_physiology1.16636196
109MP0008004_abnormal_stomach_pH1.15805444
110MP0003183_abnormal_peptide_metabolism1.15200029
111MP0004381_abnormal_hair_follicle1.14953100
112MP0002229_neurodegeneration1.14582964
113MP0003763_abnormal_thymus_physiology1.14170890
114MP0003879_abnormal_hair_cell1.13278241
115MP0002396_abnormal_hematopoietic_system1.11769563
116MP0002722_abnormal_immune_system1.11308982
117MP0003656_abnormal_erythrocyte_physiolo1.10352329
118MP0002102_abnormal_ear_morphology1.10331791
119MP0003453_abnormal_keratinocyte_physiol1.08322741
120MP0005646_abnormal_pituitary_gland1.07491364
121MP0002876_abnormal_thyroid_physiology1.07329317
122MP0006072_abnormal_retinal_apoptosis1.04411640
123MP0002638_abnormal_pupillary_reflex1.04401366
124MP0003634_abnormal_glial_cell1.02178110
125MP0001502_abnormal_circadian_rhythm1.00168927
126MP0002752_abnormal_somatic_nervous0.99706053
127MP0008872_abnormal_physiological_respon0.99314025
128MP0006292_abnormal_olfactory_placode0.98838690
129MP0002277_abnormal_respiratory_mucosa0.97410028
130MP0005076_abnormal_cell_differentiation0.93834927
131MP0002139_abnormal_hepatobiliary_system0.93560635
132MP0005379_endocrine/exocrine_gland_phen0.92818905
133MP0004808_abnormal_hematopoietic_stem0.92114569
134MP0004883_abnormal_blood_vessel0.90173597
135MP0000026_abnormal_inner_ear0.89636772
136MP0003631_nervous_system_phenotype0.88655965
137MP0002152_abnormal_brain_morphology0.88452093
138MP0001851_eye_inflammation0.87985605
139MP0008877_abnormal_DNA_methylation0.87333219
140MP0004811_abnormal_neuron_physiology0.87153902
141MP0003632_abnormal_nervous_system0.86120738
142MP0005164_abnormal_response_to0.84665387
143MP0003787_abnormal_imprinting0.83586043
144MP0003866_abnormal_defecation0.81725455
145MP0008260_abnormal_autophagy0.81631965
146MP0005535_abnormal_body_temperature0.79785698
147MP0003633_abnormal_nervous_system0.79577355
148MP0003091_abnormal_cell_migration0.79478148
149MP0005410_abnormal_fertilization0.78990823
150MP0003938_abnormal_ear_development0.78469901
151MP0000631_abnormal_neuroendocrine_gland0.77777964
152MP0009763_increased_sensitivity_to0.77655355
153MP0000465_gastrointestinal_hemorrhage0.76792247
154MP0002163_abnormal_gland_morphology0.76374610
155MP0001727_abnormal_embryo_implantation0.75206448
156MP0000604_amyloidosis0.74009384
157MP0001663_abnormal_digestive_system0.73967736
158MP0006035_abnormal_mitochondrial_morpho0.72757589
159MP0008874_decreased_physiological_sensi0.72721034
160MP0005174_abnormal_tail_pigmentation0.72561254
161MP0004885_abnormal_endolymph0.72268925
162MP0000703_abnormal_thymus_morphology0.72196580
163MP0001873_stomach_inflammation0.71556884
164MP0000490_abnormal_crypts_of0.70908644
165MP0003795_abnormal_bone_structure0.70354248
166MP0002751_abnormal_autonomic_nervous0.68941516
167MP0003718_maternal_effect0.68154837
168MP0005394_taste/olfaction_phenotype0.67721709
169MP0005499_abnormal_olfactory_system0.67721709
170MP0005253_abnormal_eye_physiology0.67571624
171MP0004185_abnormal_adipocyte_glucose0.67497349
172MP0005390_skeleton_phenotype0.67392683
173MP0002069_abnormal_eating/drinking_beha0.65754829
174MP0002332_abnormal_exercise_endurance0.65440970
175MP0005165_increased_susceptibility_to0.64486538
176MP0003705_abnormal_hypodermis_morpholog0.61335563
177MP0002090_abnormal_vision0.61000133
178MP0005195_abnormal_posterior_eye0.60131246
179MP0001664_abnormal_digestion0.59877992
180MP0001177_atelectasis0.59060363
181MP0000249_abnormal_blood_vessel0.57888357
182MP0002254_reproductive_system_inflammat0.57646931
183MP0009765_abnormal_xenobiotic_induced0.55223318
184MP0003045_fibrosis0.55109911
185MP0005647_abnormal_sex_gland0.54068604
186MP0001849_ear_inflammation0.53995405
187MP0002933_joint_inflammation0.53101288
188MP0002877_abnormal_melanocyte_morpholog0.50168689
189MP0005666_abnormal_adipose_tissue0.50132290

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.19311390
2Abnormality of liposaccharide metabolism (HP:0010968)5.99792211
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.99792211
4Abnormality of glycolipid metabolism (HP:0010969)5.99792211
5Increased cerebral lipofuscin (HP:0011813)5.06326470
6Recurrent abscess formation (HP:0002722)4.90441093
7Abnormality of macrophages (HP:0004311)4.82829447
8Recurrent bacterial skin infections (HP:0005406)4.75029746
9Systemic lupus erythematosus (HP:0002725)4.73579807
10Eczematoid dermatitis (HP:0000976)4.53814112
11Acute necrotizing encephalopathy (HP:0006965)4.45916298
12Increased neuronal autofluorescent lipopigment (HP:0002074)4.32289623
13Vacuolated lymphocytes (HP:0001922)4.11459535
14Dysostosis multiplex (HP:0000943)4.06455380
15Atonic seizures (HP:0010819)3.88525921
16Progressive macrocephaly (HP:0004481)3.88193150
17Loss of speech (HP:0002371)3.86326740
18Mitochondrial inheritance (HP:0001427)3.84107391
19Focal seizures (HP:0007359)3.82781426
20Myokymia (HP:0002411)3.78021860
21Mediastinal lymphadenopathy (HP:0100721)3.75710558
22Disinhibition (HP:0000734)3.75266964
23Abnormal mitochondria in muscle tissue (HP:0008316)3.73670138
24Recurrent gram-negative bacterial infections (HP:0005420)3.64042353
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.61496567
26Parakeratosis (HP:0001036)3.60256323
27Febrile seizures (HP:0002373)3.55691753
28Glomerulonephritis (HP:0000099)3.51540514
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.51252339
30Renal Fanconi syndrome (HP:0001994)3.43896598
31Myositis (HP:0100614)3.38980120
32Acute encephalopathy (HP:0006846)3.31494116
33Epileptic encephalopathy (HP:0200134)3.31022675
34Increased hepatocellular lipid droplets (HP:0006565)3.29794375
35Stomatitis (HP:0010280)3.21087201
36Recurrent fungal infections (HP:0002841)3.20568000
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.19311804
38Dialeptic seizures (HP:0011146)3.19232665
39Recurrent skin infections (HP:0001581)3.14495974
40Orchitis (HP:0100796)3.14473052
41Neuronal loss in central nervous system (HP:0002529)3.12132367
42Obstructive lung disease (HP:0006536)3.11750596
43Chronic obstructive pulmonary disease (HP:0006510)3.11750596
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.10131079
45Absence seizures (HP:0002121)3.10041738
46Degeneration of the lateral corticospinal tracts (HP:0002314)3.08924486
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.08924486
48Increased CSF lactate (HP:0002490)2.95834738
49Recurrent cutaneous fungal infections (HP:0011370)2.94902743
50Chronic mucocutaneous candidiasis (HP:0002728)2.94902743
51Autoimmune thrombocytopenia (HP:0001973)2.91225289
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.89331160
53Abnormality of polysaccharide metabolism (HP:0011012)2.89331160
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.89331160
55Visual hallucinations (HP:0002367)2.89209845
56Optic disc pallor (HP:0000543)2.88814619
57Amyloidosis (HP:0011034)2.87584318
58Optic neuritis (HP:0100653)2.86990394
59Retrobulbar optic neuritis (HP:0100654)2.86990394
60Axonal loss (HP:0003447)2.85563732
61Generalized tonic-clonic seizures (HP:0002069)2.85081379
62Progressive cerebellar ataxia (HP:0002073)2.82872292
63Upper motor neuron abnormality (HP:0002127)2.81712744
64Meningitis (HP:0001287)2.81619215
65Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.78671677
66Hepatocellular necrosis (HP:0001404)2.75714268
67Gingivitis (HP:0000230)2.75660620
68Recurrent viral infections (HP:0004429)2.74461719
69Hyperventilation (HP:0002883)2.74327531
70Apathy (HP:0000741)2.74196413
71Urinary glycosaminoglycan excretion (HP:0003541)2.72418037
72Mucopolysacchariduria (HP:0008155)2.72418037
73Diminished motivation (HP:0000745)2.66327195
74Progressive inability to walk (HP:0002505)2.65730332
75Elevated erythrocyte sedimentation rate (HP:0003565)2.63936289
76Peripheral hypomyelination (HP:0007182)2.63911509
77Spontaneous hematomas (HP:0007420)2.61639896
78Abnormality of the corticospinal tract (HP:0002492)2.60566520
79Progressive external ophthalmoplegia (HP:0000590)2.59115386
80Neurofibrillary tangles (HP:0002185)2.58834934
81Complement deficiency (HP:0004431)2.57654731
82Cellulitis (HP:0100658)2.56739833
83Leukodystrophy (HP:0002415)2.55920783
84Lipid accumulation in hepatocytes (HP:0006561)2.55293474
85Purpura (HP:0000979)2.55248333
86Abnormal respiratory motile cilium morphology (HP:0005938)2.51843668
87Abnormal respiratory epithelium morphology (HP:0012253)2.51843668
88Increased serum ferritin (HP:0003281)2.49008532
89Gait imbalance (HP:0002141)2.48135017
90Sensory axonal neuropathy (HP:0003390)2.46816759
91Medial flaring of the eyebrow (HP:0010747)2.46719362
92Personality changes (HP:0000751)2.45881935
93Abnormal ciliary motility (HP:0012262)2.45539110
94Colitis (HP:0002583)2.44709782
95Abnormality of renal resorption (HP:0011038)2.44309137
96Agnosia (HP:0010524)2.43906498
97Broad-based gait (HP:0002136)2.43827227
98Polyphagia (HP:0002591)2.43586462
99Abnormal hair whorl (HP:0010721)2.41358353
1003-Methylglutaconic aciduria (HP:0003535)2.33224867
101Limb dystonia (HP:0002451)2.32978705
102Abnormality of the vasculature of the conjunctiva (HP:0008054)2.30992531
103Petechiae (HP:0000967)2.29923809
104Congenital primary aphakia (HP:0007707)2.29026683
105Absent/shortened dynein arms (HP:0200106)2.28391275
106Dynein arm defect of respiratory motile cilia (HP:0012255)2.28391275
107Hemoptysis (HP:0002105)2.26314207
108Vasculitis (HP:0002633)2.25759173
109Exercise intolerance (HP:0003546)2.25733621
110Abnormality of glycolysis (HP:0004366)2.24555895
111Increased serum pyruvate (HP:0003542)2.24555895
112Increased IgE level (HP:0003212)2.23268972
113Urticaria (HP:0001025)2.23102421
114Abnormality of complement system (HP:0005339)2.22562313
115Dysmetria (HP:0001310)2.20692252
116Thoracic kyphosis (HP:0002942)2.20182233
117Vaginal atresia (HP:0000148)2.19227159
118Nuclear cataract (HP:0100018)2.18245108
119Congenital ichthyosiform erythroderma (HP:0007431)2.17164903
120Pulmonary infiltrates (HP:0002113)2.16926818
121Inappropriate behavior (HP:0000719)2.16595750
122Fetal akinesia sequence (HP:0001989)2.15154312
123Genital tract atresia (HP:0001827)2.15039776
124Dementia (HP:0000726)2.14320031
125Inflammation of the large intestine (HP:0002037)2.13247298
126Exertional dyspnea (HP:0002875)2.12705586
127Nephrogenic diabetes insipidus (HP:0009806)2.12342302
128Gaze-evoked nystagmus (HP:0000640)2.12298307
129Abnormality of iron homeostasis (HP:0011031)2.12224969
130Gastrointestinal inflammation (HP:0004386)2.11797922
131Abnormal delayed hypersensitivity skin test (HP:0002963)2.09703824
132Inability to walk (HP:0002540)2.08585936
133Global brain atrophy (HP:0002283)2.07948811
134Truncal ataxia (HP:0002078)2.05881660
135Osteomyelitis (HP:0002754)2.05134467
136Encephalitis (HP:0002383)2.04190071
137Abnormal pupillary function (HP:0007686)2.03592344
138Progressive neurologic deterioration (HP:0002344)2.03465118
139Respiratory failure (HP:0002878)2.03197068
140Supranuclear gaze palsy (HP:0000605)2.02960339
141Anxiety (HP:0000739)2.02026924
142Delusions (HP:0000746)2.00864677
143Increased intramyocellular lipid droplets (HP:0012240)2.00793511
144Cerebral hypomyelination (HP:0006808)1.99831010
145Keratoconjunctivitis sicca (HP:0001097)1.98490511
146Panhypogammaglobulinemia (HP:0003139)1.98104688
147Cerebral edema (HP:0002181)1.97614186
148Slow saccadic eye movements (HP:0000514)1.96235884
149Esotropia (HP:0000565)1.96175481
150Pustule (HP:0200039)1.96167727
151X-linked dominant inheritance (HP:0001423)1.96078348
152Hematochezia (HP:0002573)1.96031185
153Abnormal eating behavior (HP:0100738)1.95965835
154T lymphocytopenia (HP:0005403)1.95894926
155Memory impairment (HP:0002354)1.95555319
156Mutism (HP:0002300)1.95049220
157Spastic gait (HP:0002064)1.94866453
158Pathologic fracture (HP:0002756)1.94812228
159Epistaxis (HP:0000421)1.94309449
160Hemiparesis (HP:0001269)1.93346671
161Amblyopia (HP:0000646)1.93221208
162Scanning speech (HP:0002168)1.91185451
163Basal ganglia calcification (HP:0002135)1.91107126
164Polygenic inheritance (HP:0010982)1.90837259
165Myocardial infarction (HP:0001658)1.89520427
166Cerebral inclusion bodies (HP:0100314)1.88874817
167Leukocytosis (HP:0001974)1.85670132
168Gastrointestinal infarctions (HP:0005244)1.83968199
169Hepatic necrosis (HP:0002605)1.82752759
170Spondylolisthesis (HP:0003302)1.81822912
171Abnormality of the periventricular white matter (HP:0002518)1.81780273
172Peripheral demyelination (HP:0011096)1.80668223
173Restrictive lung disease (HP:0002091)1.79801295
174Gastrointestinal stroma tumor (HP:0100723)1.79615880
175Abnormal respiratory motile cilium physiology (HP:0012261)1.78501236
176Excessive salivation (HP:0003781)1.77732940
177Drooling (HP:0002307)1.77732940
178Diplopia (HP:0000651)1.77008992
179Abnormality of binocular vision (HP:0011514)1.77008992
180Interstitial pulmonary disease (HP:0006530)1.76786963
181Bone pain (HP:0002653)1.76466166
182Lactic acidosis (HP:0003128)1.75756262
183Generalized myoclonic seizures (HP:0002123)1.73010861
184Increased serum lactate (HP:0002151)1.72410157
185Hepatosplenomegaly (HP:0001433)1.71592596
186Pancreatic fibrosis (HP:0100732)1.71468996
187Abnormality of midbrain morphology (HP:0002418)1.71162297
188Molar tooth sign on MRI (HP:0002419)1.71162297
189Cerebral hemorrhage (HP:0001342)1.70760985
190Akinesia (HP:0002304)1.68370913
191Dysdiadochokinesis (HP:0002075)1.67583558
192Abnormality of the axillary hair (HP:0100134)1.67100969
193Abnormality of secondary sexual hair (HP:0009888)1.67100969
194Diminished movement (HP:0002374)1.66347580
195Cupped ear (HP:0000378)1.66281591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.35425512
2NTRK32.96633622
3CASK2.87306296
4RIPK42.81762793
5TNIK2.69929266
6MARK12.68881174
7ERN12.57719201
8MAP4K12.55188295
9MAP3K142.46461488
10MAP2K32.36218797
11TYK22.27407555
12NME22.25745633
13FES2.21809427
14MAP2K72.21221264
15CSF1R2.14762976
16GRK72.13460049
17MAP3K122.06574788
18MAP3K42.06257213
19MAP3K112.05664013
20EPHA42.04005885
21TGFBR21.92713483
22KIT1.91859764
23TAOK11.88095976
24STK161.85224276
25TBK11.84179664
26GRK51.81669177
27IRAK41.80905946
28ADRBK21.79728010
29MAP3K91.74972529
30IRAK31.73576843
31STK391.73134967
32BMPR21.69855454
33OXSR11.69663585
34CSK1.69072100
35TAOK21.68789653
36NME11.66629058
37ZAP701.58085773
38PINK11.57909447
39RIPK11.57824011
40ARAF1.56480915
41MAP3K31.53468970
42IRAK21.52297135
43MST41.52250706
44CDK191.51487964
45SYK1.46066370
46FGR1.42250941
47CAMK1D1.38485843
48MATK1.37905970
49PKN11.34152349
50MAPK131.34078168
51JAK31.32352421
52TRIB31.32274079
53PLK21.31341181
54NTRK11.25458696
55MAP3K11.23782948
56MINK11.20250570
57IKBKB1.19200136
58MAP2K41.18584061
59IKBKE1.16800157
60CAMK2B1.16577745
61LYN1.10934830
62CDC42BPA1.10699439
63JAK21.10225782
64NEK61.10207950
65JAK11.07301172
66BMPR1B1.06729573
67PLK41.04676711
68BTK1.04442502
69CAMK2A1.03522429
70HCK1.01489641
71MARK21.01448319
72SIK21.00075730
73NTRK20.98375295
74ZAK0.96923851
75TESK20.96316082
76PIM20.94751163
77PDPK10.94300216
78BCR0.93572831
79CDK50.92541288
80MOS0.91765203
81PDK10.90257844
82ICK0.89872432
83SMG10.89038700
84MAPK120.87978594
85CAMKK10.87909605
86MAP3K130.87584495
87MAPK150.87427927
88DDR20.85024925
89LCK0.83450405
90PBK0.83285118
91PRKCG0.82722546
92CDK60.82219067
93UHMK10.82148586
94MAPKAPK50.81912522
95CAMK2D0.79257732
96PRKCE0.78587891
97EPHB10.78291708
98IRAK10.78242162
99STK100.78085262
100CAMK1G0.77708316
101PRKD20.76201153
102AKT30.75797964
103CSNK1G30.75723634
104EIF2AK30.75561151
105CSNK1G20.73139940
106KSR20.72329013
107MUSK0.69104338
108GRK60.68958531
109VRK10.68390833
110CAMKK20.68022814
111MARK30.66590117
112TXK0.66413005
113BUB10.66108046
114CDK120.65473375
115BRAF0.65439577
116CLK10.64707664
117GRK10.63890099
118PAK60.62936181
119CAMK2G0.62775212
120MAPK70.62030078
121CAMK10.58496189
122RPS6KC10.56943372
123RPS6KL10.56943372
124WNK40.56844378
125MAP2K60.56744659
126EEF2K0.56335640
127TLK10.56331025
128WNK10.55442756
129DYRK1A0.55150969
130SIK30.53981897
131MAP3K60.53351409
132SRPK10.53307135
133ROCK20.52988907
134ABL20.51885236
135DAPK20.51795538
136SGK2230.51195943
137SGK4940.51195943
138SIK10.50767375
139PLK30.50245773
140PRPF4B0.49916649
141MAPK40.49488541
142CSNK1A1L0.49069348
143RPS6KA20.48330208
144ADRBK10.48239430
145TNK20.46987450
146CDK40.46785858
147PRKACA0.46740082
148MAP3K50.46648962
149ACVR1B0.44289067
150ITK0.42920289
151CDK140.42864167
152FYN0.42258244
153CHUK0.42128799
154MAP3K80.41728896
155RPS6KA60.41322456
156YES10.41305024
157BLK0.40678653
158CDK180.40528255
159HIPK20.40439864
160INSRR0.40386565
161ERBB40.40307473
162CDK150.40227703
163PTK2B0.40159754
164PRKG10.39510784
165PIM10.39166154
166CDK11A0.38834194
167TAOK30.38302735
168DYRK20.37933218
169SGK10.37357088
170ALK0.36868489
171EIF2AK20.36036725
172CSNK1G10.35989064
173TEC0.34930606
174TESK10.32789298
175FLT30.31970007
176PRKD30.31191560
177CAMK40.28843189
178SGK30.28244287
179DAPK10.26131141

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.54690191
2Nicotine addiction_Homo sapiens_hsa050333.67353062
3Other glycan degradation_Homo sapiens_hsa005113.61836602
4Parkinsons disease_Homo sapiens_hsa050123.53530466
5Alzheimers disease_Homo sapiens_hsa050103.02762537
6Osteoclast differentiation_Homo sapiens_hsa043802.94309558
7Leishmaniasis_Homo sapiens_hsa051402.80684697
8Collecting duct acid secretion_Homo sapiens_hsa049662.65480972
9Huntingtons disease_Homo sapiens_hsa050162.61243929
10Lysosome_Homo sapiens_hsa041422.56421721
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50023217
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.44525840
13GABAergic synapse_Homo sapiens_hsa047272.42846730
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.34510346
15Synaptic vesicle cycle_Homo sapiens_hsa047212.32206877
16Tuberculosis_Homo sapiens_hsa051522.28614384
17Morphine addiction_Homo sapiens_hsa050322.25623651
18Serotonergic synapse_Homo sapiens_hsa047262.25536299
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.12274741
20Glutamatergic synapse_Homo sapiens_hsa047242.08984350
21Asthma_Homo sapiens_hsa053102.04753961
22Allograft rejection_Homo sapiens_hsa053302.02308931
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97673368
24RNA polymerase_Homo sapiens_hsa030201.96087270
25B cell receptor signaling pathway_Homo sapiens_hsa046621.96027601
26Cardiac muscle contraction_Homo sapiens_hsa042601.91036212
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87636522
28Taste transduction_Homo sapiens_hsa047421.86244631
29Proteasome_Homo sapiens_hsa030501.83264589
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.81448937
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78557965
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77701145
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.75124044
34Pertussis_Homo sapiens_hsa051331.74240898
35Legionellosis_Homo sapiens_hsa051341.71054644
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.68337052
37Circadian entrainment_Homo sapiens_hsa047131.68216509
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.66440754
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65783405
40Malaria_Homo sapiens_hsa051441.63271332
41Olfactory transduction_Homo sapiens_hsa047401.60621384
42Antigen processing and presentation_Homo sapiens_hsa046121.57190864
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55697609
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.55282947
45Amphetamine addiction_Homo sapiens_hsa050311.53343984
46Ribosome_Homo sapiens_hsa030101.52122971
47Ether lipid metabolism_Homo sapiens_hsa005651.52072995
48Toxoplasmosis_Homo sapiens_hsa051451.51399394
49TNF signaling pathway_Homo sapiens_hsa046681.48982520
50Acute myeloid leukemia_Homo sapiens_hsa052211.47469372
51Influenza A_Homo sapiens_hsa051641.45291847
52Long-term depression_Homo sapiens_hsa047301.41145478
53Vibrio cholerae infection_Homo sapiens_hsa051101.39488280
54Salivary secretion_Homo sapiens_hsa049701.39164080
55Hematopoietic cell lineage_Homo sapiens_hsa046401.38515576
56Long-term potentiation_Homo sapiens_hsa047201.35707773
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35044300
58Salmonella infection_Homo sapiens_hsa051321.33612973
59Rheumatoid arthritis_Homo sapiens_hsa053231.31825599
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30090019
61SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29419935
62Dopaminergic synapse_Homo sapiens_hsa047281.28470615
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26316596
64Cholinergic synapse_Homo sapiens_hsa047251.25985115
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23708740
66Phototransduction_Homo sapiens_hsa047441.22890908
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22133302
68Fatty acid elongation_Homo sapiens_hsa000621.21332315
69Protein export_Homo sapiens_hsa030601.19001576
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16083909
71Calcium signaling pathway_Homo sapiens_hsa040201.13169298
72Primary immunodeficiency_Homo sapiens_hsa053401.08715186
73Viral myocarditis_Homo sapiens_hsa054161.06834515
74Measles_Homo sapiens_hsa051621.05899797
75Cocaine addiction_Homo sapiens_hsa050301.04400379
76Insulin secretion_Homo sapiens_hsa049111.03592471
77Herpes simplex infection_Homo sapiens_hsa051681.03211274
78Renin secretion_Homo sapiens_hsa049240.99208869
79Steroid biosynthesis_Homo sapiens_hsa001000.99060822
80Sphingolipid metabolism_Homo sapiens_hsa006000.97058313
81Axon guidance_Homo sapiens_hsa043600.96707325
82T cell receptor signaling pathway_Homo sapiens_hsa046600.95569209
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95082109
84Hepatitis C_Homo sapiens_hsa051600.94112819
85Hepatitis B_Homo sapiens_hsa051610.92643016
86VEGF signaling pathway_Homo sapiens_hsa043700.91333314
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91183382
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89297549
89Gastric acid secretion_Homo sapiens_hsa049710.89289227
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84915938
91Shigellosis_Homo sapiens_hsa051310.84095147
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.83999096
93Apoptosis_Homo sapiens_hsa042100.82146147
94Platelet activation_Homo sapiens_hsa046110.79561729
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.79112439
96African trypanosomiasis_Homo sapiens_hsa051430.77377683
97Amoebiasis_Homo sapiens_hsa051460.74832479
98Chronic myeloid leukemia_Homo sapiens_hsa052200.73992461
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72265250
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.72240164
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71346182
102GnRH signaling pathway_Homo sapiens_hsa049120.70797015
103* Oxytocin signaling pathway_Homo sapiens_hsa049210.69271034
104Phagosome_Homo sapiens_hsa041450.68962229
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68888600
106Arachidonic acid metabolism_Homo sapiens_hsa005900.68294410
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67753658
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.66751091
109Non-small cell lung cancer_Homo sapiens_hsa052230.66492696
110Bladder cancer_Homo sapiens_hsa052190.66041348
111Pancreatic cancer_Homo sapiens_hsa052120.65556438
112Type I diabetes mellitus_Homo sapiens_hsa049400.65461276
113Prolactin signaling pathway_Homo sapiens_hsa049170.64016876
114Epstein-Barr virus infection_Homo sapiens_hsa051690.62802785
115Endocytosis_Homo sapiens_hsa041440.62474723
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61274460
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59100128
118Type II diabetes mellitus_Homo sapiens_hsa049300.59054852
119Butanoate metabolism_Homo sapiens_hsa006500.57936601
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.57894289
121Pyrimidine metabolism_Homo sapiens_hsa002400.57471245
122Linoleic acid metabolism_Homo sapiens_hsa005910.57372395
123Gap junction_Homo sapiens_hsa045400.55946010
124HIF-1 signaling pathway_Homo sapiens_hsa040660.54295842
125Renal cell carcinoma_Homo sapiens_hsa052110.51683679
126Purine metabolism_Homo sapiens_hsa002300.51452126
127Vitamin B6 metabolism_Homo sapiens_hsa007500.51451606
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50511289
129Non-homologous end-joining_Homo sapiens_hsa034500.50328624
130Notch signaling pathway_Homo sapiens_hsa043300.49905295
131Systemic lupus erythematosus_Homo sapiens_hsa053220.47856591
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46372905
133mTOR signaling pathway_Homo sapiens_hsa041500.45995663
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45777576
135HTLV-I infection_Homo sapiens_hsa051660.45589542
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44956129
137cAMP signaling pathway_Homo sapiens_hsa040240.44840535
138Pancreatic secretion_Homo sapiens_hsa049720.44432333
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44155758
140Metabolic pathways_Homo sapiens_hsa011000.43944364
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43424870
142Complement and coagulation cascades_Homo sapiens_hsa046100.41622684
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40589450
144Ras signaling pathway_Homo sapiens_hsa040140.40278588
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.39559605
146Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37962716
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.37350340
148Viral carcinogenesis_Homo sapiens_hsa052030.37283616
149Alcoholism_Homo sapiens_hsa050340.36973772
150Prion diseases_Homo sapiens_hsa050200.35246231
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.34193963
152Tyrosine metabolism_Homo sapiens_hsa003500.33933162
153Galactose metabolism_Homo sapiens_hsa000520.33543114
154Estrogen signaling pathway_Homo sapiens_hsa049150.32936651
155Glioma_Homo sapiens_hsa052140.32702969
156Ovarian steroidogenesis_Homo sapiens_hsa049130.32702856
157Arginine and proline metabolism_Homo sapiens_hsa003300.32225745
158Phenylalanine metabolism_Homo sapiens_hsa003600.30682669
159Choline metabolism in cancer_Homo sapiens_hsa052310.30019059
160ErbB signaling pathway_Homo sapiens_hsa040120.28989493
161Dorso-ventral axis formation_Homo sapiens_hsa043200.28426004
162Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26491501
163MAPK signaling pathway_Homo sapiens_hsa040100.25884206
164Sulfur metabolism_Homo sapiens_hsa009200.25196860
165alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24828077
166Histidine metabolism_Homo sapiens_hsa003400.23024750
167Melanogenesis_Homo sapiens_hsa049160.22916614
168Staphylococcus aureus infection_Homo sapiens_hsa051500.22831428
169Oocyte meiosis_Homo sapiens_hsa041140.22532735
170Chemokine signaling pathway_Homo sapiens_hsa040620.22498738
171Autoimmune thyroid disease_Homo sapiens_hsa053200.20242015
172Graft-versus-host disease_Homo sapiens_hsa053320.18745808

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