TRPM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.53876996
2cellular potassium ion homeostasis (GO:0030007)5.26524755
3short-term memory (GO:0007614)5.17447189
4sodium ion export (GO:0071436)5.00240214
5potassium ion import (GO:0010107)4.90242410
6gamma-aminobutyric acid transport (GO:0015812)4.86983725
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.79420572
8alanine transport (GO:0032328)4.76083898
9vitamin A metabolic process (GO:0006776)4.73922594
10cerebellar granule cell differentiation (GO:0021707)4.37408765
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.31209427
12cellular sodium ion homeostasis (GO:0006883)4.27526964
13presynaptic membrane organization (GO:0097090)4.26490174
14proline transport (GO:0015824)4.25043298
15L-amino acid import (GO:0043092)4.22269815
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.15178227
17righting reflex (GO:0060013)4.14047614
18synaptic vesicle maturation (GO:0016188)4.10387812
19cell communication by electrical coupling (GO:0010644)4.05898285
20synaptic transmission, glutamatergic (GO:0035249)4.04895876
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01565735
22positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.99570778
23amino acid import (GO:0043090)3.94525773
24neuronal action potential propagation (GO:0019227)3.94228736
25vocalization behavior (GO:0071625)3.94091809
26* glutamate receptor signaling pathway (GO:0007215)3.92490579
27cerebellar Purkinje cell differentiation (GO:0021702)3.89078065
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87740046
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.87463546
30synaptic vesicle exocytosis (GO:0016079)3.86393729
31epithelial cilium movement (GO:0003351)3.82842195
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80821101
33cilium movement (GO:0003341)3.75399618
34glutamate secretion (GO:0014047)3.72153945
35exploration behavior (GO:0035640)3.70124103
36regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.69179428
37membrane repolarization (GO:0086009)3.67386647
38regulation of glutamate receptor signaling pathway (GO:1900449)3.64696647
39response to auditory stimulus (GO:0010996)3.61841514
40potassium ion homeostasis (GO:0055075)3.58537803
41long-term memory (GO:0007616)3.57872726
42negative regulation of hormone biosynthetic process (GO:0032353)3.56978953
43regulation of synaptic vesicle exocytosis (GO:2000300)3.54084913
44neurotransmitter secretion (GO:0007269)3.52964800
45auditory behavior (GO:0031223)3.51897309
46neurotransmitter-gated ion channel clustering (GO:0072578)3.50766895
47mesenchymal cell proliferation (GO:0010463)3.48018869
48neuron-neuron synaptic transmission (GO:0007270)3.46939352
49synaptic vesicle docking involved in exocytosis (GO:0016081)3.45783921
50* G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.45050347
51C4-dicarboxylate transport (GO:0015740)3.43141155
52intraciliary transport (GO:0042073)3.40614085
53regulation of non-canonical Wnt signaling pathway (GO:2000050)3.39883363
54dendrite morphogenesis (GO:0048813)3.32496878
55regulation of long-term neuronal synaptic plasticity (GO:0048169)3.29959357
56nonmotile primary cilium assembly (GO:0035058)3.29322453
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.27643267
58diterpenoid biosynthetic process (GO:0016102)3.27286285
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27277943
60inner ear receptor stereocilium organization (GO:0060122)3.27021876
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26587527
62regulation of neuronal synaptic plasticity (GO:0048168)3.26369805
63L-serine transport (GO:0015825)3.25909391
64layer formation in cerebral cortex (GO:0021819)3.24857096
65cell differentiation in hindbrain (GO:0021533)3.23978665
66protein localization to synapse (GO:0035418)3.23148802
67limb bud formation (GO:0060174)3.21871048
68behavioral defense response (GO:0002209)3.21563747
69behavioral fear response (GO:0001662)3.21563747
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.21347472
71neuron cell-cell adhesion (GO:0007158)3.20937573
72response to pheromone (GO:0019236)3.20780105
73innervation (GO:0060384)3.19549401
74glycine transport (GO:0015816)3.18355690
75transmission of nerve impulse (GO:0019226)3.18338272
76positive regulation of potassium ion transmembrane transport (GO:1901381)3.18248028
77regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.14369653
78regulation of synaptic vesicle transport (GO:1902803)3.09915255
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08519557
80retinal ganglion cell axon guidance (GO:0031290)3.07522085
81auditory receptor cell stereocilium organization (GO:0060088)3.07025047
82neuromuscular process controlling balance (GO:0050885)3.06519571
83membrane repolarization during action potential (GO:0086011)3.05682189
84prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.05400731
85retinal cone cell development (GO:0046549)3.05365978
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04786884
87regulation of membrane repolarization (GO:0060306)3.04474852
88serotonin receptor signaling pathway (GO:0007210)3.01684420
89retina layer formation (GO:0010842)2.97825577
90neurotransmitter transport (GO:0006836)2.97795642
91negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94140660
92reflex (GO:0060004)2.92619190
93neuronal ion channel clustering (GO:0045161)2.90631386
94negative regulation of hormone metabolic process (GO:0032351)2.90383304
95retinal metabolic process (GO:0042574)2.89741926
96cilium organization (GO:0044782)2.88810793
97regulation of phospholipid biosynthetic process (GO:0071071)2.88293781
98positive regulation of synapse maturation (GO:0090129)2.87840759
99protein targeting to vacuole (GO:0006623)2.87779970
100protein targeting to lysosome (GO:0006622)2.87779970
101establishment of protein localization to vacuole (GO:0072666)2.87779970
102postsynaptic membrane organization (GO:0001941)2.87019254
103acidic amino acid transport (GO:0015800)2.86516073
104secondary metabolite biosynthetic process (GO:0044550)2.86282723
105cilium assembly (GO:0042384)2.86002217
106behavioral response to cocaine (GO:0048148)2.85861999
107regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85699389
108photoreceptor cell development (GO:0042461)2.85550118
109fear response (GO:0042596)2.84883010
110mechanosensory behavior (GO:0007638)2.84400149
111regulation of feeding behavior (GO:0060259)2.82925074
112gamma-aminobutyric acid signaling pathway (GO:0007214)2.82920790
113cellular response to electrical stimulus (GO:0071257)2.82794191
114membrane hyperpolarization (GO:0060081)2.81433000
115positive regulation of amino acid transport (GO:0051957)2.80633511
116regulation of beta-amyloid formation (GO:1902003)2.80245032
117establishment of nucleus localization (GO:0040023)2.79473823
118smoothened signaling pathway (GO:0007224)2.79384118
119lateral sprouting from an epithelium (GO:0060601)2.79342006
120regulation of postsynaptic membrane potential (GO:0060078)2.78857380
121detection of light stimulus involved in visual perception (GO:0050908)2.78537229
122detection of light stimulus involved in sensory perception (GO:0050962)2.78537229
123regulation of synaptic transmission, glutamatergic (GO:0051966)2.78009498
124startle response (GO:0001964)2.77997987
125synaptic vesicle endocytosis (GO:0048488)2.77341040
126ketone body metabolic process (GO:1902224)2.76900074
127dendritic spine morphogenesis (GO:0060997)2.76280883
128regulation of synapse structural plasticity (GO:0051823)2.76266138
129positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.76011800
130type B pancreatic cell development (GO:0003323)2.75618923
131regulation of neurotransmitter levels (GO:0001505)2.75336051
132membrane depolarization during action potential (GO:0086010)2.74854935
133positive regulation of potassium ion transport (GO:0043268)2.74578219
134regulation of respiratory gaseous exchange (GO:0043576)2.74353300
135midbrain development (GO:0030901)2.73511392
136serine transport (GO:0032329)2.73438631
137neuromuscular process controlling posture (GO:0050884)2.73294383
138otic vesicle formation (GO:0030916)2.73287494
139regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.71432129
140regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.68391756
141regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.68210019
142regulation of potassium ion transmembrane transport (GO:1901379)2.67697519
143eye photoreceptor cell development (GO:0042462)2.67532103
144negative chemotaxis (GO:0050919)2.67438666
145detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66736378
146regulation of voltage-gated calcium channel activity (GO:1901385)2.64915828
147synapse assembly (GO:0007416)2.64850946
148negative regulation of sodium ion transport (GO:0010766)2.64402204
149positive regulation of membrane potential (GO:0045838)2.63151578
150axoneme assembly (GO:0035082)2.62113213
151presynaptic membrane assembly (GO:0097105)2.61813878
152regulation of synaptic plasticity (GO:0048167)2.60780893
153cilium morphogenesis (GO:0060271)2.60516427
154adult walking behavior (GO:0007628)2.60087641
155limb development (GO:0060173)2.60057117
156appendage development (GO:0048736)2.60057117
157cranial suture morphogenesis (GO:0060363)2.59372761
158neuron fate determination (GO:0048664)2.58942825
159neurotransmitter uptake (GO:0001504)2.58503233
160positive regulation of dendritic spine morphogenesis (GO:0061003)2.57863887
161axonal fasciculation (GO:0007413)2.57863716
162long-term synaptic potentiation (GO:0060291)2.57702220
163neuromuscular process (GO:0050905)2.57558502
164regulation of cell communication by electrical coupling (GO:0010649)2.56743612
165protein localization to cilium (GO:0061512)2.55783993
166dorsal/ventral neural tube patterning (GO:0021904)2.54131530
167photoreceptor cell maintenance (GO:0045494)2.53788443
168positive regulation of sodium ion transmembrane transport (GO:1902307)2.53641545
169axonemal dynein complex assembly (GO:0070286)2.52162152
170behavioral response to nicotine (GO:0035095)2.51724652
171central nervous system myelination (GO:0022010)2.50067011
172axon ensheathment in central nervous system (GO:0032291)2.50067011
173terpenoid biosynthetic process (GO:0016114)2.47918418
174positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.47895056
175platelet dense granule organization (GO:0060155)2.45769590
176branch elongation of an epithelium (GO:0060602)2.44096581
177positive regulation of meiosis (GO:0045836)2.43181702

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.51848047
2GBX2_23144817_ChIP-Seq_PC3_Human3.27804556
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97377905
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84423141
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66931139
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56899852
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56899852
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53533911
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53370330
10DROSHA_22980978_ChIP-Seq_HELA_Human2.48912694
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38310703
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35889672
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35423158
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31416413
15FUS_26573619_Chip-Seq_HEK293_Human2.30523040
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.29787361
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24519603
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17046696
19* REST_21632747_ChIP-Seq_MESCs_Mouse2.08109685
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07710152
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.06246952
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05248042
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.04399481
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.04001829
25AR_21572438_ChIP-Seq_LNCaP_Human1.96000278
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95051790
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.92265677
28VDR_22108803_ChIP-Seq_LS180_Human1.85975226
29EWS_26573619_Chip-Seq_HEK293_Human1.78180346
30IGF1R_20145208_ChIP-Seq_DFB_Human1.78179730
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72723754
32RNF2_27304074_Chip-Seq_NSC_Mouse1.67781752
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64494542
34* RARB_27405468_Chip-Seq_BRAIN_Mouse1.63369437
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.62253660
36* REST_18959480_ChIP-ChIP_MESCs_Mouse1.58760198
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58441794
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58062503
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57452554
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52333980
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50178746
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48111158
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46450039
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45635091
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.43350168
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42180470
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.41655632
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41429028
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40659909
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.37396106
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36502821
52TP53_16413492_ChIP-PET_HCT116_Human1.35487932
53AR_19668381_ChIP-Seq_PC3_Human1.33454104
54* P300_19829295_ChIP-Seq_ESCs_Human1.31456767
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31080991
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31064593
57CBP_20019798_ChIP-Seq_JUKART_Human1.31064593
58* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30945428
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.30402295
60* STAT3_23295773_ChIP-Seq_U87_Human1.30319420
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.29350398
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28568420
63AR_25329375_ChIP-Seq_VCAP_Human1.27370845
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27027990
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26984011
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26433129
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25670288
68AHR_22903824_ChIP-Seq_MCF-7_Human1.24954559
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.24192607
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23509976
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23154523
72* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22957368
73* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22487079
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.21516093
75* TCF4_22108803_ChIP-Seq_LS180_Human1.19627155
76* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19409605
77RXR_22108803_ChIP-Seq_LS180_Human1.19080077
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18679105
79LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16074395
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14641225
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13671500
82ER_23166858_ChIP-Seq_MCF-7_Human1.12374609
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12273868
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12115869
85* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11953771
86* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11870959
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11749197
88* TCF4_23295773_ChIP-Seq_U87_Human1.11739999
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10934985
90TP53_18474530_ChIP-ChIP_U2OS_Human1.10861739
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10634212
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10188727
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.09670308
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08855174
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08855174
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07917338
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06997166
98NANOG_19829295_ChIP-Seq_ESCs_Human1.06701634
99SOX2_19829295_ChIP-Seq_ESCs_Human1.06701634
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05679090
101BCAT_22108803_ChIP-Seq_LS180_Human1.05625279
102P53_22387025_ChIP-Seq_ESCs_Mouse1.05004403
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.04834078
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.04457197
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04145444
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.03781470
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.03593452
108* SOX9_26525672_Chip-Seq_HEART_Mouse1.03115750
109SMAD4_21741376_ChIP-Seq_HESCs_Human1.02550354
110RUNX2_22187159_ChIP-Seq_PCA_Human1.02397602
111TAF15_26573619_Chip-Seq_HEK293_Human1.01571481
112* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01468738
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00797954
114DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00618684
115* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99797196
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.99707989
117* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99632080
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99405669
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99340176
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99040456
121P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98530546
122KDM2B_26808549_Chip-Seq_K562_Human0.98338843
123EP300_21415370_ChIP-Seq_HL-1_Mouse0.97468633
124ZNF274_21170338_ChIP-Seq_K562_Hela0.96857441
125SMAD3_21741376_ChIP-Seq_HESCs_Human0.96042364
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95039321
127* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94829272
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93525962
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92614591
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92419439
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91673784
132* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91605309
133* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88115004
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87238986
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.86971915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.84221318
2MP0003136_yellow_coat_color3.38532164
3MP0009046_muscle_twitch3.34011109
4MP0003635_abnormal_synaptic_transmissio3.24634399
5MP0004270_analgesia3.08580802
6MP0001486_abnormal_startle_reflex2.72212897
7MP0004885_abnormal_endolymph2.68226741
8MP0005423_abnormal_somatic_nervous2.63508591
9MP0005171_absent_coat_pigmentation2.61153567
10MP0003880_abnormal_central_pattern2.60269511
11MP0009745_abnormal_behavioral_response2.58501961
12MP0002064_seizures2.57189018
13MP0002102_abnormal_ear_morphology2.54692975
14MP0003879_abnormal_hair_cell2.53157020
15MP0002063_abnormal_learning/memory/cond2.41739291
16MP0009780_abnormal_chondrocyte_physiolo2.39590655
17MP0002272_abnormal_nervous_system2.39362390
18MP0001968_abnormal_touch/_nociception2.30533740
19MP0004858_abnormal_nervous_system2.29434768
20MP0010030_abnormal_orbit_morphology2.27342683
21MP0002572_abnormal_emotion/affect_behav2.22819216
22MP0001485_abnormal_pinna_reflex2.18764206
23MP0002734_abnormal_mechanical_nocicepti2.17809431
24MP0008569_lethality_at_weaning2.11815968
25MP0001440_abnormal_grooming_behavior2.08012356
26MP0005377_hearing/vestibular/ear_phenot2.02994797
27MP0003878_abnormal_ear_physiology2.02994797
28MP0002067_abnormal_sensory_capabilities1.95766346
29MP0003690_abnormal_glial_cell1.88731589
30MP0003122_maternal_imprinting1.86610034
31MP0002735_abnormal_chemical_nociception1.80163419
32MP0002736_abnormal_nociception_after1.78316980
33MP0005551_abnormal_eye_electrophysiolog1.76546236
34MP0001502_abnormal_circadian_rhythm1.74001893
35MP0001501_abnormal_sleep_pattern1.71849716
36MP0001963_abnormal_hearing_physiology1.63994995
37MP0005257_abnormal_intraocular_pressure1.61877822
38MP0003329_amyloid_beta_deposits1.61662443
39MP0003011_delayed_dark_adaptation1.60580502
40MP0002557_abnormal_social/conspecific_i1.59238615
41MP0003938_abnormal_ear_development1.55227717
42MP0003633_abnormal_nervous_system1.53460356
43MP0000778_abnormal_nervous_system1.52453646
44MP0001970_abnormal_pain_threshold1.50219001
45MP0002733_abnormal_thermal_nociception1.50206737
46MP0002184_abnormal_innervation1.49051974
47MP0004142_abnormal_muscle_tone1.46927567
48MP0002234_abnormal_pharynx_morphology1.45060970
49MP0001299_abnormal_eye_distance/1.42745797
50MP0001293_anophthalmia1.39244004
51MP0002882_abnormal_neuron_morphology1.38257077
52MP0003631_nervous_system_phenotype1.37688657
53MP0005646_abnormal_pituitary_gland1.37395778
54MP0003632_abnormal_nervous_system1.34603461
55MP0002233_abnormal_nose_morphology1.33806210
56MP0005391_vision/eye_phenotype1.33130869
57MP0005253_abnormal_eye_physiology1.33047499
58MP0005386_behavior/neurological_phenoty1.32615010
59MP0004924_abnormal_behavior1.32615010
60MP0006292_abnormal_olfactory_placode1.28987015
61MP0002229_neurodegeneration1.27487380
62MP0000026_abnormal_inner_ear1.23697469
63MP0000955_abnormal_spinal_cord1.23684673
64MP0002089_abnormal_postnatal_growth/wei1.23385557
65MP0004145_abnormal_muscle_electrophysio1.21738752
66MP0003634_abnormal_glial_cell1.21020773
67MP0004043_abnormal_pH_regulation1.19094460
68MP0008004_abnormal_stomach_pH1.17277338
69MP0009384_cardiac_valve_regurgitation1.16673021
70MP0003937_abnormal_limbs/digits/tail_de1.15888415
71MP0000383_abnormal_hair_follicle1.15003255
72MP0000462_abnormal_digestive_system1.14867224
73MP0002638_abnormal_pupillary_reflex1.14515762
74MP0004811_abnormal_neuron_physiology1.13080708
75MP0002066_abnormal_motor_capabilities/c1.13021499
76MP0001346_abnormal_lacrimal_gland1.10891040
77MP0001984_abnormal_olfaction1.10508358
78MP0004742_abnormal_vestibular_system1.07723058
79MP0006072_abnormal_retinal_apoptosis1.07626094
80MP0005367_renal/urinary_system_phenotyp1.04367567
81MP0000516_abnormal_urinary_system1.04367567
82MP0003119_abnormal_digestive_system1.03722910
83MP0004147_increased_porphyrin_level1.01572990
84MP0002653_abnormal_ependyma_morphology0.99729690
85MP0000566_synostosis0.99610576
86MP0000920_abnormal_myelination0.99353953
87MP0008877_abnormal_DNA_methylation0.98262599
88MP0001177_atelectasis0.98219015
89MP0003045_fibrosis0.98198699
90MP0002152_abnormal_brain_morphology0.97276833
91MP0000569_abnormal_digit_pigmentation0.96724642
92MP0005645_abnormal_hypothalamus_physiol0.93001695
93MP0001529_abnormal_vocalization0.92884164
94MP0003121_genomic_imprinting0.92036051
95MP0002752_abnormal_somatic_nervous0.91745923
96MP0005394_taste/olfaction_phenotype0.90587574
97MP0005499_abnormal_olfactory_system0.90587574
98MP0000372_irregular_coat_pigmentation0.90068813
99MP0001286_abnormal_eye_development0.90055272
100MP0005197_abnormal_uvea_morphology0.88278110
101MP0004215_abnormal_myocardial_fiber0.88204395
102MP0004233_abnormal_muscle_weight0.88180940
103MP0003137_abnormal_impulse_conducting0.88167935
104MP0002095_abnormal_skin_pigmentation0.87918872
105MP0005248_abnormal_Harderian_gland0.87250997
106MP0005409_darkened_coat_color0.86755844
107MP0008789_abnormal_olfactory_epithelium0.86007155
108MP0002090_abnormal_vision0.85660182
109MP0003172_abnormal_lysosome_physiology0.85486225
110MP0002909_abnormal_adrenal_gland0.84998022
111MP0005187_abnormal_penis_morphology0.84252254
112MP0002697_abnormal_eye_size0.82697168
113MP0000647_abnormal_sebaceous_gland0.81923454
114MP0005408_hypopigmentation0.81801435
115MP0002254_reproductive_system_inflammat0.79454665
116MP0000537_abnormal_urethra_morphology0.78130050
117MP0003755_abnormal_palate_morphology0.76675380
118MP0003787_abnormal_imprinting0.76424327
119MP0003283_abnormal_digestive_organ0.75538632
120MP0006276_abnormal_autonomic_nervous0.72118038
121MP0003183_abnormal_peptide_metabolism0.71988459
122MP0000579_abnormal_nail_morphology0.71595672
123MP0000631_abnormal_neuroendocrine_gland0.71397334
124MP0000751_myopathy0.69117620
125MP0001324_abnormal_eye_pigmentation0.68648700
126MP0008961_abnormal_basal_metabolism0.68257250
127MP0004085_abnormal_heartbeat0.66677356
128MP0000604_amyloidosis0.64739474
129MP0005195_abnormal_posterior_eye0.64492710
130MP0002108_abnormal_muscle_morphology0.63543813
131MP0003646_muscle_fatigue0.62572072
132MP0002938_white_spotting0.61375445

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.14816015
2Action tremor (HP:0002345)5.09186060
3Aplasia involving bones of the extremities (HP:0009825)4.63534300
4Aplasia involving bones of the upper limbs (HP:0009823)4.63534300
5Aplasia of the phalanges of the hand (HP:0009802)4.63534300
6True hermaphroditism (HP:0010459)4.28731657
7Pancreatic fibrosis (HP:0100732)4.17778142
8Focal seizures (HP:0007359)4.07171108
9Progressive cerebellar ataxia (HP:0002073)3.96721854
10Molar tooth sign on MRI (HP:0002419)3.91262610
11Abnormality of midbrain morphology (HP:0002418)3.91262610
12Pancreatic cysts (HP:0001737)3.77280119
13Hemiparesis (HP:0001269)3.76648109
14Myokymia (HP:0002411)3.59094533
15Epileptic encephalopathy (HP:0200134)3.46100617
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.40874351
17Abnormal ciliary motility (HP:0012262)3.36834879
18Visual hallucinations (HP:0002367)3.31161335
19Megalencephaly (HP:0001355)3.30199592
20Abnormality of binocular vision (HP:0011514)3.19373767
21Diplopia (HP:0000651)3.19373767
22Medial flaring of the eyebrow (HP:0010747)3.18033498
23Nephronophthisis (HP:0000090)3.17279288
24Hemiplegia (HP:0002301)3.14994488
25Gait imbalance (HP:0002141)3.13508503
26Occipital encephalocele (HP:0002085)3.10007164
27Febrile seizures (HP:0002373)3.08043106
28Abnormal respiratory motile cilium physiology (HP:0012261)3.05904960
29Mixed hearing impairment (HP:0000410)3.04587576
30Cystic liver disease (HP:0006706)3.00102765
31Dysdiadochokinesis (HP:0002075)2.99968367
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.99021295
33Vaginal atresia (HP:0000148)2.97078792
34Genital tract atresia (HP:0001827)2.93104456
35Hyperactive renin-angiotensin system (HP:0000841)2.90991332
36Congenital primary aphakia (HP:0007707)2.90372409
37Concave nail (HP:0001598)2.89588017
38Rhinitis (HP:0012384)2.87471686
39Ventricular fibrillation (HP:0001663)2.86823242
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.83294782
41Hypoplasia of the fovea (HP:0007750)2.83294782
42Gaze-evoked nystagmus (HP:0000640)2.82919843
43Atonic seizures (HP:0010819)2.81083330
44Chronic hepatic failure (HP:0100626)2.81006400
45Blue irides (HP:0000635)2.80018849
46Sclerocornea (HP:0000647)2.76034325
47Metabolic alkalosis (HP:0200114)2.75260222
48Generalized tonic-clonic seizures (HP:0002069)2.72948096
49Postural instability (HP:0002172)2.70793352
50Abnormal rod and cone electroretinograms (HP:0008323)2.69060745
51Truncal ataxia (HP:0002078)2.66911663
52Bony spicule pigmentary retinopathy (HP:0007737)2.66390852
53Postaxial foot polydactyly (HP:0001830)2.64975504
54Abnormality of the phalanges of the 2nd finger (HP:0009541)2.64037376
55Intention tremor (HP:0002080)2.63765456
56Genetic anticipation (HP:0003743)2.63313754
57Nephrogenic diabetes insipidus (HP:0009806)2.58127562
58Supranuclear gaze palsy (HP:0000605)2.56908344
59Synostosis involving the elbow (HP:0003938)2.54106187
60Humeroradial synostosis (HP:0003041)2.54106187
61Absence seizures (HP:0002121)2.53636377
62Dialeptic seizures (HP:0011146)2.51116551
63Anencephaly (HP:0002323)2.49547703
64Optic nerve hypoplasia (HP:0000609)2.49327302
65Hypokalemic alkalosis (HP:0001949)2.48376375
66Polyuria (HP:0000103)2.48067829
67Abnormality of the renal medulla (HP:0100957)2.47917568
68Scanning speech (HP:0002168)2.44919212
69Midline defect of the nose (HP:0004122)2.44753667
70Broad-based gait (HP:0002136)2.43173402
71Abnormality of the labia minora (HP:0012880)2.40872569
72Status epilepticus (HP:0002133)2.38791019
73Attenuation of retinal blood vessels (HP:0007843)2.37128243
74Abnormal eating behavior (HP:0100738)2.35408805
75Scotoma (HP:0000575)2.34497834
76Postaxial hand polydactyly (HP:0001162)2.34069042
77Preaxial hand polydactyly (HP:0001177)2.33954865
78Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.32852645
79Absent speech (HP:0001344)2.32633004
80Abnormal respiratory motile cilium morphology (HP:0005938)2.31325485
81Abnormal respiratory epithelium morphology (HP:0012253)2.31325485
82Arterial tortuosity (HP:0005116)2.27190438
83Dysmetria (HP:0001310)2.24527770
84Postural tremor (HP:0002174)2.23918753
85Abnormality of the fovea (HP:0000493)2.23289112
86Abnormality of macular pigmentation (HP:0008002)2.21689136
87Prolonged QT interval (HP:0001657)2.19502017
88Depression (HP:0000716)2.19484619
89Congenital hepatic fibrosis (HP:0002612)2.16526093
90Congenital stationary night blindness (HP:0007642)2.16363978
91Alacrima (HP:0000522)2.16102925
92Abnormality of ocular smooth pursuit (HP:0000617)2.15246812
93Impaired smooth pursuit (HP:0007772)2.14489600
94Split foot (HP:0001839)2.13889658
95Dysmetric saccades (HP:0000641)2.10861560
96Decreased central vision (HP:0007663)2.10244150
97Hypopigmentation of the fundus (HP:0007894)2.07911045
98Bilateral microphthalmos (HP:0007633)2.06723083
99Hyperaldosteronism (HP:0000859)2.02671329
100Aplasia/Hypoplasia of the macula (HP:0008059)2.02315586
101Abdominal situs inversus (HP:0003363)2.02305183
102Abnormality of abdominal situs (HP:0011620)2.02305183
103Bell-shaped thorax (HP:0001591)2.01997253
104Vascular tortuosity (HP:0004948)2.01960487
105Poor coordination (HP:0002370)1.99608758
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99550519
107Abnormality of the dental pulp (HP:0006479)1.98680935
108Tubular atrophy (HP:0000092)1.98483301
109Choroideremia (HP:0001139)1.97874202
110Vitreoretinal degeneration (HP:0000655)1.96728468
111Aqueductal stenosis (HP:0002410)1.95931792
112Keratoconus (HP:0000563)1.95696357
113Increased corneal curvature (HP:0100692)1.95696357
114Epiphyseal dysplasia (HP:0002656)1.95468876
115Neurofibrillary tangles (HP:0002185)1.94730327
116Bile duct proliferation (HP:0001408)1.94012648
117Abnormal biliary tract physiology (HP:0012439)1.94012648
118Abnormal urine output (HP:0012590)1.92991092
119Abnormality of renin-angiotensin system (HP:0000847)1.91882875
120Polydipsia (HP:0001959)1.91768578
121Abnormal drinking behavior (HP:0030082)1.91768578
122Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.89492916
123Cutaneous finger syndactyly (HP:0010554)1.88149677
124Aplasia/Hypoplasia affecting the retina (HP:0008061)1.87761241
125Hepatoblastoma (HP:0002884)1.86962913
126Abnormality of permanent molar morphology (HP:0011071)1.86222967
127Abnormality of the dental root (HP:0006486)1.86222967
128Taurodontia (HP:0000679)1.86222967
129Neoplasm of the heart (HP:0100544)1.84527032
130Hypoplastic nipples (HP:0002557)1.83937079
131Trigonocephaly (HP:0000243)1.83891650
132Abnormal auditory evoked potentials (HP:0006958)1.82939695
133Hyperglycinemia (HP:0002154)1.82365067
134Male pseudohermaphroditism (HP:0000037)1.82174178
135Furrowed tongue (HP:0000221)1.81589651
136Abnormality of the renal cortex (HP:0011035)1.81296621
137Urinary bladder sphincter dysfunction (HP:0002839)1.81237297
138Impaired vibration sensation in the lower limbs (HP:0002166)1.81164670
139Abnormality of the pubic bones (HP:0003172)1.81109913
140Macular degeneration (HP:0000608)1.81000765
141Drooling (HP:0002307)1.80346907
142Excessive salivation (HP:0003781)1.80346907
143Aplasia/Hypoplasia of the lens (HP:0008063)1.79712907
144Limb dystonia (HP:0002451)1.79466595
145Mutism (HP:0002300)1.78892397
146Abnormality of the middle phalanges of the toes (HP:0010183)1.78730459
147Narrow forehead (HP:0000341)1.78349394
148Abnormality of molar (HP:0011077)1.78100914
149Abnormality of molar morphology (HP:0011070)1.78100914
150Abolished electroretinogram (ERG) (HP:0000550)1.77550038
151Pheochromocytoma (HP:0002666)1.77546926
152Ankle clonus (HP:0011448)1.76130564
153Tetraplegia (HP:0002445)1.75931918
154Bifid tongue (HP:0010297)1.75928317
155Stomach cancer (HP:0012126)1.75897014
156Poor eye contact (HP:0000817)1.73311607
157Abnormal social behavior (HP:0012433)1.73067757
158Impaired social interactions (HP:0000735)1.73067757
159Clumsiness (HP:0002312)1.70691166
160Stereotypic behavior (HP:0000733)1.69455691
161Macroorchidism (HP:0000053)1.69451998
162Long nose (HP:0003189)1.69434971
163Narrow nasal bridge (HP:0000446)1.69057223
164Anteriorly placed anus (HP:0001545)1.68534612
165Bradykinesia (HP:0002067)1.65840477
166Abnormality of the lower motor neuron (HP:0002366)1.65347521
167Decreased lacrimation (HP:0000633)1.65331612
168Abnormality of the diencephalon (HP:0010662)1.64080944
169Peripheral hypomyelination (HP:0007182)1.63109752
170Anophthalmia (HP:0000528)1.62198226
171Anxiety (HP:0000739)1.60990026
172Abnormal EKG (HP:0003115)1.59249447
173Turricephaly (HP:0000262)1.57905278
174Increased circulating renin level (HP:0000848)1.57659679
175Polyphagia (HP:0002591)1.57347619
176Spastic gait (HP:0002064)1.57226037
177Hyperventilation (HP:0002883)1.56320484
178Cerebral inclusion bodies (HP:0100314)1.56070838
179Abnormality of the lacrimal duct (HP:0011481)1.54053317

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.34622436
2NTRK33.75681613
3FRK3.22182625
4PRKD33.21664578
5NTRK22.73231712
6PASK2.60669820
7MAP3K42.58524581
8MAP3K92.50601258
9MARK12.40974571
10EPHA42.39444607
11DDR22.33075632
12WNK32.20360518
13MAP2K72.20178429
14PHKG22.15223284
15PHKG12.15223284
16STK38L2.03474398
17LMTK21.89080832
18MINK11.87246165
19CAMKK11.73759699
20WNK11.68399936
21SGK21.67182723
22MAPK131.66002899
23RIPK11.65499215
24PAK61.59782491
25CASK1.56232510
26NTRK11.55568217
27STK381.54530568
28CAMKK21.50799116
29SGK31.48740702
30NUAK11.44589531
31SGK2231.44449155
32SGK4941.44449155
33DAPK21.41594747
34MAP2K41.40991864
35BMPR1B1.37036773
36LATS11.29678573
37CAMK1G1.29448500
38PRKCG1.28599192
39CDK81.23680814
40CDK51.23275430
41FGFR21.20601787
42MAP4K21.18121710
43PRKCH1.17521739
44INSRR1.13331542
45CSNK1G11.06561857
46RIPK41.04523988
47EPHA31.01909636
48SIK11.01457598
49ADRBK20.99212600
50GRK10.96787694
51PRPF4B0.96292530
52RET0.93911881
53STK390.93719426
54SIK20.89983754
55KSR20.89869936
56CDC42BPA0.88686013
57MET0.88130458
58SGK10.87857212
59TSSK60.86269412
60PTK2B0.85009852
61MAP3K130.83924124
62WNK40.83277731
63NEK60.81988642
64TGFBR10.81175003
65STK240.81091823
66KSR10.78883640
67CAMK10.78848489
68STK160.78597150
69PLK20.77662123
70CAMK2A0.77505285
71MAP3K120.77233326
72MAP3K60.76232988
73MAP3K70.75091729
74PRKCE0.74967151
75PNCK0.74919233
76TYRO30.74759122
77MARK20.74732918
78PINK10.74522005
79UHMK10.74138717
80MST1R0.74043379
81AKT30.73422330
82DYRK20.72303153
83GRK50.72256392
84STK110.71453373
85CSNK1G30.71408337
86ALK0.68774025
87PRKACB0.67897984
88CAMK1D0.67318596
89DYRK1A0.65591337
90CSNK1A1L0.64400049
91CAMK40.63696981
92ERBB30.63149374
93MELK0.62785124
94FGFR10.62488916
95BCKDK0.62118961
96NLK0.61489877
97MAP3K20.61116168
98PRKACA0.60806686
99MAPK120.59824034
100FES0.58367229
101PKN10.58017431
102RPS6KA30.55152525
103PAK30.54819992
104BMX0.54647504
105OXSR10.53832685
106CDK190.53488923
107PDK10.53192401
108CAMK2B0.53066812
109DMPK0.50714030
110CAMK2G0.49554281
111DAPK10.49343599
112MAPK100.49117287
113PRKCZ0.47606045
114PDPK10.46929549
115STK30.46835318
116MKNK10.46787915
117CDK150.45322262
118CSNK1D0.45250317
119CAMK2D0.44675297
120PRKD20.44508093
121BCR0.43776628
122MKNK20.43620035
123CDK180.42801218
124ERBB20.42633662
125PRKG10.42381499
126PRKAA10.42379857
127PLK30.42147163
128FGFR30.41715519
129MUSK0.41388199
130TLK10.41310305
131MAPK150.40997984
132ROCK20.40817196
133EPHB20.40717645
134PRKCA0.40343404
135CSNK1G20.40311459
136LATS20.40016059
137HIPK20.37673085
138CSNK1A10.37642601
139PRKCB0.37609523
140MAPK70.37557170
141ZAK0.37333524

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.48518428
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.58044047
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54213651
4GABAergic synapse_Homo sapiens_hsa047272.45991580
5Glutamatergic synapse_Homo sapiens_hsa047242.45639935
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.38414291
7Circadian entrainment_Homo sapiens_hsa047132.34524493
8Nitrogen metabolism_Homo sapiens_hsa009102.29094646
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22150134
10Long-term potentiation_Homo sapiens_hsa047202.20840809
11Synaptic vesicle cycle_Homo sapiens_hsa047212.19413884
12Salivary secretion_Homo sapiens_hsa049702.13571168
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05223293
14Insulin secretion_Homo sapiens_hsa049112.04103559
15Gastric acid secretion_Homo sapiens_hsa049712.02111059
16Morphine addiction_Homo sapiens_hsa050321.99570004
17Oxidative phosphorylation_Homo sapiens_hsa001901.89366440
18Olfactory transduction_Homo sapiens_hsa047401.88122119
19Amphetamine addiction_Homo sapiens_hsa050311.84677673
20Butanoate metabolism_Homo sapiens_hsa006501.80544762
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.70419202
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65422537
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60881042
24Taste transduction_Homo sapiens_hsa047421.58245876
25Long-term depression_Homo sapiens_hsa047301.52038224
26Calcium signaling pathway_Homo sapiens_hsa040201.50326776
27Cholinergic synapse_Homo sapiens_hsa047251.46354938
28Dopaminergic synapse_Homo sapiens_hsa047281.46331371
29Fatty acid biosynthesis_Homo sapiens_hsa000611.44240684
30Parkinsons disease_Homo sapiens_hsa050121.43397962
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38357469
32Alzheimers disease_Homo sapiens_hsa050101.33626233
33Renin secretion_Homo sapiens_hsa049241.33494910
34Cocaine addiction_Homo sapiens_hsa050301.33372641
35TGF-beta signaling pathway_Homo sapiens_hsa043501.33133347
36cAMP signaling pathway_Homo sapiens_hsa040241.32740629
37Protein export_Homo sapiens_hsa030601.31566211
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27699988
39Type II diabetes mellitus_Homo sapiens_hsa049301.27624655
40Histidine metabolism_Homo sapiens_hsa003401.27178047
41beta-Alanine metabolism_Homo sapiens_hsa004101.25956820
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23742467
43Huntingtons disease_Homo sapiens_hsa050161.20456017
44Dorso-ventral axis formation_Homo sapiens_hsa043201.20258202
45Serotonergic synapse_Homo sapiens_hsa047261.19837139
46Oxytocin signaling pathway_Homo sapiens_hsa049211.19097063
47Bile secretion_Homo sapiens_hsa049761.17929231
48GnRH signaling pathway_Homo sapiens_hsa049121.17406552
49Propanoate metabolism_Homo sapiens_hsa006401.16278787
50Pancreatic secretion_Homo sapiens_hsa049721.15375424
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15107147
52Circadian rhythm_Homo sapiens_hsa047101.13732460
53Melanogenesis_Homo sapiens_hsa049161.12888268
54Ether lipid metabolism_Homo sapiens_hsa005651.12600441
55Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10716413
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09057854
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08906185
58Gap junction_Homo sapiens_hsa045401.08016778
59Phototransduction_Homo sapiens_hsa047441.07689773
60Linoleic acid metabolism_Homo sapiens_hsa005911.05233090
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04106829
62Estrogen signaling pathway_Homo sapiens_hsa049151.02531738
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02498139
64Thyroid hormone synthesis_Homo sapiens_hsa049181.00913999
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00895173
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00637305
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00200469
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.98604075
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98365748
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97819756
71Dilated cardiomyopathy_Homo sapiens_hsa054140.97797029
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96703188
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94540244
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94450895
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91547996
76Regulation of autophagy_Homo sapiens_hsa041400.91541872
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.91377631
78ErbB signaling pathway_Homo sapiens_hsa040120.87720213
79ABC transporters_Homo sapiens_hsa020100.87519532
80Glioma_Homo sapiens_hsa052140.87286376
81Axon guidance_Homo sapiens_hsa043600.86494194
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84110249
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83669165
84Inositol phosphate metabolism_Homo sapiens_hsa005620.80071112
85Tryptophan metabolism_Homo sapiens_hsa003800.77934685
86Mineral absorption_Homo sapiens_hsa049780.77200039
87Choline metabolism in cancer_Homo sapiens_hsa052310.74237423
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73846761
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72104125
90Basal cell carcinoma_Homo sapiens_hsa052170.71506273
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.70967912
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.67979884
93Cardiac muscle contraction_Homo sapiens_hsa042600.67944669
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67055458
95Wnt signaling pathway_Homo sapiens_hsa043100.65984460
96Fatty acid elongation_Homo sapiens_hsa000620.64733946
97mTOR signaling pathway_Homo sapiens_hsa041500.64539018
98Tyrosine metabolism_Homo sapiens_hsa003500.63047952
99MAPK signaling pathway_Homo sapiens_hsa040100.61705859
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61332123
101Retinol metabolism_Homo sapiens_hsa008300.61226829
102Chemical carcinogenesis_Homo sapiens_hsa052040.60749146
103Hedgehog signaling pathway_Homo sapiens_hsa043400.60592667
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59853221
105Rap1 signaling pathway_Homo sapiens_hsa040150.56445322
106Glucagon signaling pathway_Homo sapiens_hsa049220.56219073
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.56182072
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55434723
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54438833
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53172195
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52894285
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51786196
113Endometrial cancer_Homo sapiens_hsa052130.50975239
114Protein digestion and absorption_Homo sapiens_hsa049740.49562284
115Peroxisome_Homo sapiens_hsa041460.49006645
116Arginine and proline metabolism_Homo sapiens_hsa003300.47821047
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47324864
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.46901952
119Ras signaling pathway_Homo sapiens_hsa040140.46538402
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44900397
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43671026
122Fatty acid metabolism_Homo sapiens_hsa012120.42120588
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.41585538
124Ovarian steroidogenesis_Homo sapiens_hsa049130.41532832
125Collecting duct acid secretion_Homo sapiens_hsa049660.40738033
126Insulin signaling pathway_Homo sapiens_hsa049100.40396644
127Proteoglycans in cancer_Homo sapiens_hsa052050.39990424
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.37541680
129Hippo signaling pathway_Homo sapiens_hsa043900.35951858
130Melanoma_Homo sapiens_hsa052180.35291053
131Colorectal cancer_Homo sapiens_hsa052100.34178482
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34026996
133Endocytosis_Homo sapiens_hsa041440.31727165
134Oocyte meiosis_Homo sapiens_hsa041140.31592353
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30751241
136Insulin resistance_Homo sapiens_hsa049310.30457453
137Renal cell carcinoma_Homo sapiens_hsa052110.30348394
138Lysosome_Homo sapiens_hsa041420.30292458
139Lysine degradation_Homo sapiens_hsa003100.29394767

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