TRPM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)7.02005391
2intestinal epithelial cell development (GO:0060576)5.80997920
3intestinal absorption (GO:0050892)5.74419306
4maintenance of gastrointestinal epithelium (GO:0030277)5.33833558
5intestinal cholesterol absorption (GO:0030299)4.86563843
6desmosome organization (GO:0002934)4.80970337
7hemidesmosome assembly (GO:0031581)4.70136591
8sulfate transmembrane transport (GO:1902358)4.69410435
9angiotensin maturation (GO:0002003)4.56921474
10striated muscle atrophy (GO:0014891)4.54637245
11UDP-N-acetylglucosamine metabolic process (GO:0006047)4.48501438
12positive regulation of fatty acid beta-oxidation (GO:0032000)4.45386919
13skeletal muscle adaptation (GO:0043501)4.30713247
14epithelial structure maintenance (GO:0010669)4.30369025
15epithelial cell-cell adhesion (GO:0090136)4.10572008
16positive regulation of fatty acid oxidation (GO:0046321)4.03547878
17ventricular cardiac muscle cell action potential (GO:0086005)3.99460615
18actin filament depolymerization (GO:0030042)3.94705028
19muscle atrophy (GO:0014889)3.92748627
20sulfate transport (GO:0008272)3.90552632
21O-glycan processing (GO:0016266)3.83711279
22negative regulation of keratinocyte proliferation (GO:0010839)3.76948540
23digestive system process (GO:0022600)3.63920405
24sarcomere organization (GO:0045214)3.63673988
25vitamin A metabolic process (GO:0006776)3.61479564
26lung secretory cell differentiation (GO:0061140)3.47268503
273-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.42324661
28purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.42324661
29flavonoid metabolic process (GO:0009812)3.40553335
30regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.38967696
31regulation of guanylate cyclase activity (GO:0031282)3.34938545
32regulation of skeletal muscle contraction (GO:0014819)3.33078409
33adhesion of symbiont to host cell (GO:0044650)3.31881893
34virion attachment to host cell (GO:0019062)3.31881893
35regulation of fatty acid beta-oxidation (GO:0031998)3.22176208
36transcytosis (GO:0045056)3.20389981
37cytidine deamination (GO:0009972)3.14098435
38cytidine metabolic process (GO:0046087)3.14098435
39cytidine catabolic process (GO:0006216)3.14098435
40hepatocyte apoptotic process (GO:0097284)3.09964034
41positive regulation of p38MAPK cascade (GO:1900745)3.06000752
42glomerular filtration (GO:0003094)3.05711544
43actomyosin structure organization (GO:0031032)3.04246231
44positive regulation of epidermal cell differentiation (GO:0045606)3.02538626
45auditory receptor cell differentiation (GO:0042491)3.01464570
46renal filtration (GO:0097205)3.00885864
47regulation of p38MAPK cascade (GO:1900744)2.99773177
48relaxation of cardiac muscle (GO:0055119)2.97227986
49regulation of fatty acid oxidation (GO:0046320)2.95058409
50keratinocyte proliferation (GO:0043616)2.94665482
51phospholipid scrambling (GO:0017121)2.91875276
52bicarbonate transport (GO:0015701)2.91507828
53regulation of water loss via skin (GO:0033561)2.91083507
54pyrimidine ribonucleoside catabolic process (GO:0046133)2.90166445
55digestion (GO:0007586)2.89338697
56cell communication involved in cardiac conduction (GO:0086065)2.87898269
57negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.87680470
58regulation of heart rate by cardiac conduction (GO:0086091)2.86689061
59calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.86159414
60actin-mediated cell contraction (GO:0070252)2.85446006
61response to hepatocyte growth factor (GO:0035728)2.84621348
62cellular response to hepatocyte growth factor stimulus (GO:0035729)2.84621348
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.84235254
64regulation of podosome assembly (GO:0071801)2.79121242
65columnar/cuboidal epithelial cell development (GO:0002066)2.77717222
66fucose catabolic process (GO:0019317)2.77290333
67L-fucose metabolic process (GO:0042354)2.77290333
68L-fucose catabolic process (GO:0042355)2.77290333
69negative regulation of leukocyte chemotaxis (GO:0002689)2.76660380
70glutathione biosynthetic process (GO:0006750)2.76560130
71endothelial cell chemotaxis (GO:0035767)2.75963856
72actin filament-based movement (GO:0030048)2.74908953
73negative regulation of axon extension involved in axon guidance (GO:0048843)2.73962485
74behavioral response to nicotine (GO:0035095)2.71714938
75renal system process involved in regulation of blood volume (GO:0001977)2.70580894
76regulation of cardioblast differentiation (GO:0051890)2.69930565
77skeletal muscle contraction (GO:0003009)2.67525041
78protein O-linked glycosylation (GO:0006493)2.66771573
79myofibril assembly (GO:0030239)2.64647166
80negative regulation of protein localization to cell surface (GO:2000009)2.63888971
81actin-myosin filament sliding (GO:0033275)2.63114023
82muscle filament sliding (GO:0030049)2.63114023
83nonribosomal peptide biosynthetic process (GO:0019184)2.62547830
84membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.61850021
85sulfur compound transport (GO:0072348)2.61680672
86cardiac myofibril assembly (GO:0055003)2.61520793
87arginine catabolic process (GO:0006527)2.61454751
88* cardiac conduction (GO:0061337)2.60678451
89regulation of keratinocyte proliferation (GO:0010837)2.60265327
90endocardial cushion development (GO:0003197)2.59851758
91epoxygenase P450 pathway (GO:0019373)2.59321209
92adhesion of symbiont to host (GO:0044406)2.58528147
93fibroblast migration (GO:0010761)2.58122002
94galactose catabolic process (GO:0019388)2.58097647
95sulfation (GO:0051923)2.56381153
96fucosylation (GO:0036065)2.56321121
97positive regulation of epidermis development (GO:0045684)2.52810965
98thrombin receptor signaling pathway (GO:0070493)2.51565275
99phenol-containing compound catabolic process (GO:0019336)2.51462342
100vitamin transmembrane transport (GO:0035461)2.51416891
101positive regulation of guanylate cyclase activity (GO:0031284)2.50135104
102positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.49391379
103regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.49368809
104regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48882933
105regulation of interferon-beta biosynthetic process (GO:0045357)2.48035398
106striated muscle adaptation (GO:0014888)2.47914678
107phosphatidylinositol acyl-chain remodeling (GO:0036149)2.46926496
108cell-substrate junction assembly (GO:0007044)2.45712383
109sperm capacitation (GO:0048240)2.45548565
110cellular ketone body metabolic process (GO:0046950)2.44808602
111drug catabolic process (GO:0042737)2.44732629
112transepithelial transport (GO:0070633)2.44537544
113plasma membrane repair (GO:0001778)2.44152822
114positive regulation of Cdc42 GTPase activity (GO:0043089)2.43574531
115arginine metabolic process (GO:0006525)2.43507534
116peptide catabolic process (GO:0043171)2.43134576
117regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.41909012
118endocrine process (GO:0050886)2.41909012
119regulation of systemic arterial blood pressure by hormone (GO:0001990)2.41909012
120negative regulation of axon guidance (GO:1902668)2.41382735
121multicellular organismal water homeostasis (GO:0050891)2.40360335
122cell differentiation involved in embryonic placenta development (GO:0060706)2.40250369
123membrane repolarization during action potential (GO:0086011)2.39878115
124bile acid and bile salt transport (GO:0015721)2.39761854
125regulation of tight junction assembly (GO:2000810)2.39702287
126pharyngeal system development (GO:0060037)2.39322463
127positive regulation of T cell differentiation in thymus (GO:0033089)2.38767596
128regulation of systemic arterial blood pressure (GO:0003073)2.38376378
129trophectodermal cell differentiation (GO:0001829)2.37458594
130ethanol metabolic process (GO:0006067)2.37281760
131semaphorin-plexin signaling pathway (GO:0071526)2.36586227
132cellular response to ATP (GO:0071318)2.36353205
133cardiac muscle cell action potential involved in contraction (GO:0086002)2.36297913
134nucleotide-sugar biosynthetic process (GO:0009226)2.35988137
135cellular response to vitamin D (GO:0071305)2.34372727
136excretion (GO:0007588)2.34111098
137regulation of chemokine secretion (GO:0090196)2.34098715
138macroautophagy (GO:0016236)2.33737287
139atrioventricular valve morphogenesis (GO:0003181)2.33021386
140positive regulation of respiratory burst (GO:0060267)2.32914866
141positive regulation of protein kinase C signaling (GO:0090037)2.32092844
142cardiac muscle cell action potential (GO:0086001)2.32051702
143glandular epithelial cell differentiation (GO:0002067)2.31932232
144phosphatidylserine acyl-chain remodeling (GO:0036150)2.31386122
145branching involved in labyrinthine layer morphogenesis (GO:0060670)2.29944100
146interferon-gamma secretion (GO:0072643)2.29513809
147phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.29339821
148nephron epithelium morphogenesis (GO:0072088)2.29274993
149nephron tubule morphogenesis (GO:0072078)2.29274993
150positive regulation of icosanoid secretion (GO:0032305)2.28741712
151receptor guanylyl cyclase signaling pathway (GO:0007168)2.28703958
152sequestering of extracellular ligand from receptor (GO:0035581)2.28556224
153regulation of integrin activation (GO:0033623)2.27791734
154positive regulation of fatty acid transport (GO:2000193)2.27145678
155cellular response to pH (GO:0071467)2.26804990
156negative regulation of protein tyrosine kinase activity (GO:0061099)2.24601936
157water homeostasis (GO:0030104)2.23335934
158fatty acid transmembrane transport (GO:1902001)2.23055888
159oligosaccharide biosynthetic process (GO:0009312)2.22843952
160cell junction maintenance (GO:0034331)2.21676421
161regulation of cell proliferation involved in kidney development (GO:1901722)2.21569740
162regulation of ruffle assembly (GO:1900027)2.20781320
163neurotransmitter biosynthetic process (GO:0042136)2.20677344
164regulation of hippo signaling (GO:0035330)2.18943032
165lung vasculature development (GO:0060426)2.18864694
166ketone body metabolic process (GO:1902224)2.16677111
167ethanol oxidation (GO:0006069)2.15422184
168alkaloid metabolic process (GO:0009820)2.15046997
169phosphatidylserine metabolic process (GO:0006658)2.14158024
170drug metabolic process (GO:0017144)2.13962706
171growth hormone secretion (GO:0030252)2.13933275
172positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.13869510

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.04553025
2CDX2_20551321_ChIP-Seq_CACO-2_Human3.87679770
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.35360716
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.95904730
5SOX2_27498859_Chip-Seq_STOMACH_Mouse2.77925332
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.65760879
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.50115522
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.38434702
9GATA4_25053715_ChIP-Seq_YYC3_Human2.34322712
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25443219
11* SOX2_20726797_ChIP-Seq_SW620_Human2.23543048
12GATA6_25053715_ChIP-Seq_YYC3_Human2.18823143
13PPAR_26484153_Chip-Seq_NCI-H1993_Human2.09142469
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.05291620
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.04379033
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87304689
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.85388816
18RUNX1_27514584_Chip-Seq_MCF-7_Human1.83517427
19VDR_22108803_ChIP-Seq_LS180_Human1.81949550
20KLF5_25053715_ChIP-Seq_YYC3_Human1.80100216
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78872744
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76071233
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75409326
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74328099
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70558565
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69180685
27ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66476974
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62917434
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.62239268
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.58230457
31RACK7_27058665_Chip-Seq_MCF-7_Human1.58196621
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54586424
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48251941
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48251941
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46888698
36SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43446824
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43005464
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41825662
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41809253
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40954820
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40725514
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.40021916
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39830173
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.39703945
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.38572220
46TCF4_18268006_ChIP-ChIP_LS174T_Human1.37471420
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36846600
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.36708839
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35598613
50AHR_22903824_ChIP-Seq_MCF-7_Human1.35499272
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27929081
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26823678
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26571912
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24159193
55EZH2_22144423_ChIP-Seq_EOC_Human1.24002268
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22663578
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.22626849
58* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21259695
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18953989
60* ZNF274_21170338_ChIP-Seq_K562_Hela1.18282627
61CJUN_26792858_Chip-Seq_BT549_Human1.18060497
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17520189
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16227737
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16212578
65STAT1_20625510_ChIP-Seq_HELA_Human1.15833969
66* DROSHA_22980978_ChIP-Seq_HELA_Human1.15776653
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14306996
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12447239
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12266341
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12043394
71JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11967701
72E2F1_20622854_ChIP-Seq_HELA_Human1.11759251
73ZNF263_19887448_ChIP-Seq_K562_Human1.10020170
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08891451
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08575432
76ATF3_27146783_Chip-Seq_COLON_Human1.08413370
77ERA_21632823_ChIP-Seq_H3396_Human1.07596765
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06882046
79P68_20966046_ChIP-Seq_HELA_Human1.06492683
80RXR_22158963_ChIP-Seq_LIVER_Mouse1.06016735
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05644352
82GATA3_24758297_ChIP-Seq_MCF-7_Human1.05583919
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.04940612
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.04940612
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04065223
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03980147
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.03794435
88TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03694758
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.03397994
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.03117922
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02827135
92RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00953150
93EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00953150
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.00107442
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99981731
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99718916
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99310909
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98708622
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98659882
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98557346
101BCL6_27268052_Chip-Seq_Bcells_Human0.98311797
102* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97972312
103P53_21459846_ChIP-Seq_SAOS-2_Human0.96891419
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95896136
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95754184
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95632165
107SMC4_20622854_ChIP-Seq_HELA_Human0.94980377
108LXR_22292898_ChIP-Seq_THP-1_Human0.94837872
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93916906
110LXR_22158963_ChIP-Seq_LIVER_Mouse0.93549148
111SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92904103
112FOXH1_21741376_ChIP-Seq_ESCs_Human0.92864956
113TET1_21451524_ChIP-Seq_MESCs_Mouse0.91976078
114EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91952702
115CTCF_20526341_ChIP-Seq_ESCs_Human0.91711145
116FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91540618
117SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91179856
118EZH2_27304074_Chip-Seq_ESCs_Mouse0.91052216
119PHF8_20622854_ChIP-Seq_HELA_Human0.90865999
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90121721
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.89907577
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89619045
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.89159553
124RNF2_27304074_Chip-Seq_ESCs_Mouse0.89001866
125TP63_22573176_ChIP-Seq_HFKS_Human0.88666854
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88337558
127OCT4_20526341_ChIP-Seq_ESCs_Human0.87847589
128VDR_24787735_ChIP-Seq_THP-1_Human0.87642512
129GATA2_19941826_ChIP-Seq_K562_Human0.87239798
130BCOR_27268052_Chip-Seq_Bcells_Human0.86618291
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86425118
132ISL1_27105846_Chip-Seq_CPCs_Mouse0.84870288
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84312486
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82551070
135PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81768223
136* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81286213
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81072967
138SPI1_23127762_ChIP-Seq_K562_Human0.80520131
139HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80316611
140EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79163116
141STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.78312870
142RXR_22108803_ChIP-Seq_LS180_Human0.76681007
143CTCF_27219007_Chip-Seq_Bcells_Human0.76660690
144FOXA2_19822575_ChIP-Seq_HepG2_Human0.76196100
145ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.74304703
146STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.72654654
147ELK3_25401928_ChIP-Seq_HUVEC_Human0.72400746
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72378369
149GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72177667
150SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71540524
151CREB1_26743006_Chip-Seq_LNCaP_Human0.70836345
152TP63_23658742_ChIP-Seq_EP156T_Human0.70305094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu3.83783544
2MP0010234_abnormal_vibrissa_follicle3.54302091
3MP0001666_abnormal_nutrient_absorption3.52443006
4MP0000462_abnormal_digestive_system3.22099957
5MP0003283_abnormal_digestive_organ3.21974774
6MP0003941_abnormal_skin_development3.11451006
7MP0003866_abnormal_defecation2.95079055
8MP0005670_abnormal_white_adipose2.94080118
9MP0005377_hearing/vestibular/ear_phenot2.93293677
10MP0003878_abnormal_ear_physiology2.93293677
11MP0008004_abnormal_stomach_pH2.74021299
12MP0003705_abnormal_hypodermis_morpholog2.70621762
13MP0001873_stomach_inflammation2.55664250
14MP0010155_abnormal_intestine_physiology2.52499836
15MP0005503_abnormal_tendon_morphology2.30200845
16MP0002876_abnormal_thyroid_physiology2.23183085
17MP0010352_gastrointestinal_tract_polyps2.20291198
18MP0000490_abnormal_crypts_of2.15568185
19MP0005381_digestive/alimentary_phenotyp2.14562455
20MP0002139_abnormal_hepatobiliary_system2.08929439
21MP0001663_abnormal_digestive_system2.08929104
22MP0001664_abnormal_digestion2.07717602
23MP0002822_catalepsy2.02540453
24MP0005167_abnormal_blood-brain_barrier2.02518702
25MP0003300_gastrointestinal_ulcer1.97966377
26MP0000477_abnormal_intestine_morphology1.97511124
27MP0000537_abnormal_urethra_morphology1.91385565
28MP0000013_abnormal_adipose_tissue1.87714659
29MP0005367_renal/urinary_system_phenotyp1.85426732
30MP0000516_abnormal_urinary_system1.85426732
31MP0003566_abnormal_cell_adhesion1.84987115
32MP0005085_abnormal_gallbladder_physiolo1.79600508
33MP0000538_abnormal_urinary_bladder1.78318788
34MP0003879_abnormal_hair_cell1.77755190
35MP0000230_abnormal_systemic_arterial1.74247660
36MP0000751_myopathy1.64691700
37MP0002254_reproductive_system_inflammat1.64538554
38MP0002249_abnormal_larynx_morphology1.61118554
39MP0004145_abnormal_muscle_electrophysio1.57366934
40MP0003045_fibrosis1.56915406
41MP0005083_abnormal_biliary_tract1.56382836
42MP0005365_abnormal_bile_salt1.56184088
43MP0003183_abnormal_peptide_metabolism1.53920455
44MP0001756_abnormal_urination1.50556083
45MP0001849_ear_inflammation1.48529121
46MP0003828_pulmonary_edema1.47547403
47MP0008875_abnormal_xenobiotic_pharmacok1.46382786
48MP0006054_spinal_hemorrhage1.46081170
49MP0000467_abnormal_esophagus_morphology1.45694223
50MP0002277_abnormal_respiratory_mucosa1.45208761
51MP0005360_urolithiasis1.43965220
52MP0008775_abnormal_heart_ventricle1.43947717
53MP0005310_abnormal_salivary_gland1.42631132
54MP0005409_darkened_coat_color1.42350746
55MP0001485_abnormal_pinna_reflex1.40051815
56MP0002060_abnormal_skin_morphology1.39911312
57MP0002796_impaired_skin_barrier1.37408775
58MP0000749_muscle_degeneration1.32660579
59MP0004947_skin_inflammation1.32463717
60MP0004484_altered_response_of1.32042900
61MP0000470_abnormal_stomach_morphology1.31209151
62MP0010678_abnormal_skin_adnexa1.30157279
63MP0000427_abnormal_hair_cycle1.29168779
64MP0004043_abnormal_pH_regulation1.29068101
65MP0002653_abnormal_ependyma_morphology1.26922320
66MP0005275_abnormal_skin_tensile1.24040076
67MP0008872_abnormal_physiological_respon1.21909842
68MP0003453_abnormal_keratinocyte_physiol1.20088857
69MP0004084_abnormal_cardiac_muscle1.19911071
70MP0003091_abnormal_cell_migration1.18394474
71MP0010329_abnormal_lipoprotein_level1.16819321
72MP0005666_abnormal_adipose_tissue1.15599904
73MP0003646_muscle_fatigue1.15267907
74MP0009379_abnormal_foot_pigmentation1.14392506
75MP0003279_aneurysm1.13860078
76MP0002098_abnormal_vibrissa_morphology1.12583570
77MP0005636_abnormal_mineral_homeostasis1.10803129
78MP0005076_abnormal_cell_differentiation1.09805908
79MP0005023_abnormal_wound_healing1.07033771
80MP0002108_abnormal_muscle_morphology1.06904696
81MP0000383_abnormal_hair_follicle1.06631815
82MP0005257_abnormal_intraocular_pressure1.05623407
83MP0004147_increased_porphyrin_level1.05412970
84MP0001216_abnormal_epidermal_layer1.03468129
85MP0002837_dystrophic_cardiac_calcinosis1.03046480
86MP0009384_cardiac_valve_regurgitation1.02975074
87MP0000678_abnormal_parathyroid_gland1.02162460
88MP0005332_abnormal_amino_acid1.01923656
89MP0001958_emphysema1.01286820
90MP0000026_abnormal_inner_ear1.00622849
91MP0004085_abnormal_heartbeat0.97613239
92MP0004185_abnormal_adipocyte_glucose0.97612709
93MP0001501_abnormal_sleep_pattern0.96828769
94MP0002136_abnormal_kidney_physiology0.96752334
95MP0004087_abnormal_muscle_fiber0.96200147
96MP0002138_abnormal_hepatobiliary_system0.96108920
97MP0005595_abnormal_vascular_smooth0.96000745
98MP0009780_abnormal_chondrocyte_physiolo0.94036182
99MP0005375_adipose_tissue_phenotype0.92905727
100MP0001502_abnormal_circadian_rhythm0.92099168
101MP0002896_abnormal_bone_mineralization0.91476766
102MP0005501_abnormal_skin_physiology0.89885098
103MP0004272_abnormal_basement_membrane0.89762323
104MP0005551_abnormal_eye_electrophysiolog0.89077940
105MP0000049_abnormal_middle_ear0.89046941
106MP0002972_abnormal_cardiac_muscle0.88291135
107MP0000579_abnormal_nail_morphology0.87088920
108MP0005448_abnormal_energy_balance0.85184287
109MP0003137_abnormal_impulse_conducting0.84909165
110MP0009840_abnormal_foam_cell0.83336846
111MP0000762_abnormal_tongue_morphology0.82848393
112MP0005330_cardiomyopathy0.82288723
113MP0010630_abnormal_cardiac_muscle0.80884131
114MP0003385_abnormal_body_wall0.80600247
115MP0005508_abnormal_skeleton_morphology0.80141030
116MP0009643_abnormal_urine_homeostasis0.80121161
117MP0000566_synostosis0.80022955
118MP0004036_abnormal_muscle_relaxation0.79927795
119MP0005165_increased_susceptibility_to0.79279286
120MP0000003_abnormal_adipose_tissue0.78854578
121MP0002932_abnormal_joint_morphology0.78473580
122MP0004019_abnormal_vitamin_homeostasis0.78092637
123MP0000569_abnormal_digit_pigmentation0.77408243
124MP0000767_abnormal_smooth_muscle0.76764341
125MP0004858_abnormal_nervous_system0.76562784
126MP0000534_abnormal_ureter_morphology0.75947265
127MP0008438_abnormal_cutaneous_collagen0.75440401
128MP0004782_abnormal_surfactant_physiolog0.75188673
129MP0009278_abnormal_bone_marrow0.75124892
130MP0002106_abnormal_muscle_physiology0.75065521
131MP0002118_abnormal_lipid_homeostasis0.74995641
132MP0003638_abnormal_response/metabolism_0.74870793
133* MP0001765_abnormal_ion_homeostasis0.74051002
134MP0002166_altered_tumor_susceptibility0.73858706
135MP0004215_abnormal_myocardial_fiber0.73633380
136MP0000163_abnormal_cartilage_morphology0.73410660
137MP0004133_heterotaxia0.72289205
138MP0005385_cardiovascular_system_phenoty0.70746605
139MP0001544_abnormal_cardiovascular_syste0.70746605
140MP0010771_integument_phenotype0.70698150
141MP0001191_abnormal_skin_condition0.70494171
142MP0010386_abnormal_urinary_bladder0.69005737
143MP0000750_abnormal_muscle_regeneration0.68741283
144MP0005620_abnormal_muscle_contractility0.68310254
145MP0005166_decreased_susceptibility_to0.68221117
146MP0004510_myositis0.67745278

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)7.45338365
2Ileus (HP:0002595)4.89328476
3Ventricular tachycardia (HP:0004756)4.31562606
4Mildly elevated creatine phosphokinase (HP:0008180)4.16378693
5Abnormality of glutamine family amino acid metabolism (HP:0010902)3.90544675
6Abnormality of renin-angiotensin system (HP:0000847)3.76111701
7Atrophic scars (HP:0001075)3.65768030
8Abnormality of the 1st metacarpal (HP:0010009)3.64044259
9Flat acetabular roof (HP:0003180)3.53496492
10Increased connective tissue (HP:0009025)3.51748551
11Milia (HP:0001056)3.49306162
12Abdominal distention (HP:0003270)3.42748471
13Fragile skin (HP:0001030)3.38891583
14Progressive sensorineural hearing impairment (HP:0000408)3.14965366
15Thin bony cortex (HP:0002753)3.13182374
16Abnormality of the distal phalanx of the thumb (HP:0009617)3.10511054
17Cupped ribs (HP:0000887)3.06984934
18Sudden death (HP:0001699)3.05439254
19Distal lower limb muscle weakness (HP:0009053)3.04587572
20Cervical subluxation (HP:0003308)3.04265826
21Palpitations (HP:0001962)3.02534721
22Myopathic facies (HP:0002058)3.01295077
23Amelogenesis imperfecta (HP:0000705)3.00658512
24Chronic diarrhea (HP:0002028)3.00477391
25Metabolic alkalosis (HP:0200114)2.99091698
26Type 1 muscle fiber predominance (HP:0003803)2.92957664
27Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.84339523
28J-shaped sella turcica (HP:0002680)2.81438797
29Tubular atrophy (HP:0000092)2.79857886
30Ventricular fibrillation (HP:0001663)2.78628733
31Hyperactive renin-angiotensin system (HP:0000841)2.78380531
32Congenital sensorineural hearing impairment (HP:0008527)2.72580692
33Progressive hearing impairment (HP:0001730)2.71984044
34Hypoplastic ischia (HP:0003175)2.71498055
35Short phalanx of the thumb (HP:0009660)2.70067064
36Neonatal short-limb short stature (HP:0008921)2.68281437
37Broad metatarsal (HP:0001783)2.67505011
38Ventricular arrhythmia (HP:0004308)2.66457530
39Micronodular cirrhosis (HP:0001413)2.66327612
40* Syncope (HP:0001279)2.61331841
41Lymphangioma (HP:0100764)2.55154633
42Pustule (HP:0200039)2.54007163
43Autoimmune thrombocytopenia (HP:0001973)2.51946617
44Abnormality of the gastric mucosa (HP:0004295)2.50393079
45Exercise-induced myalgia (HP:0003738)2.49666041
46Onycholysis (HP:0001806)2.48578428
47Cheilitis (HP:0100825)2.45946036
48Woolly hair (HP:0002224)2.45391098
49Hyporeflexia of lower limbs (HP:0002600)2.43309615
50Hyperaldosteronism (HP:0000859)2.42915700
51Aplasia/hypoplasia of the femur (HP:0005613)2.38995364
52Cystic liver disease (HP:0006706)2.38640254
53Alkalosis (HP:0001948)2.38455244
54Concave nail (HP:0001598)2.38266983
55Rectal prolapse (HP:0002035)2.38112946
56Stridor (HP:0010307)2.37093526
57Curly hair (HP:0002212)2.36279607
58Abnormality of chloride homeostasis (HP:0011422)2.35673733
59Genetic anticipation (HP:0003743)2.34677858
60Symphalangism affecting the phalanges of the hand (HP:0009773)2.33409625
61Villous atrophy (HP:0011473)2.32484551
62Abnormality of small intestinal villus morphology (HP:0011472)2.32484551
63Short hallux (HP:0010109)2.32035915
64Absent phalangeal crease (HP:0006109)2.31865064
65Alopecia of scalp (HP:0002293)2.30839471
66Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.29626840
67Lipoatrophy (HP:0100578)2.29078691
68Keratoconus (HP:0000563)2.28976794
69Increased corneal curvature (HP:0100692)2.28976794
70Hypoplasia of dental enamel (HP:0006297)2.28188781
71Plantar hyperkeratosis (HP:0007556)2.26968666
72Hyperkalemia (HP:0002153)2.26801986
73Premature loss of primary teeth (HP:0006323)2.26400064
74Aplasia cutis congenita (HP:0001057)2.24806026
75Abnormality of the ischium (HP:0003174)2.24659172
76Flat capital femoral epiphysis (HP:0003370)2.20662292
77Hyperparathyroidism (HP:0000843)2.20657979
78Aortic regurgitation (HP:0001659)2.19875564
79Pendular nystagmus (HP:0012043)2.19724329
80Pancreatic fibrosis (HP:0100732)2.19666657
81Calf muscle hypertrophy (HP:0008981)2.18935980
82Cerebral palsy (HP:0100021)2.15193256
83Pancreatic cysts (HP:0001737)2.14884419
84Abnormal hair laboratory examination (HP:0003328)2.13909903
85Dilated cardiomyopathy (HP:0001644)2.11217315
86Confusion (HP:0001289)2.10829152
87Ureteral stenosis (HP:0000071)2.10757678
88Abnormality of the calf musculature (HP:0001430)2.09835940
89Pili torti (HP:0003777)2.09492138
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09256464
91Difficulty climbing stairs (HP:0003551)2.08911127
92Malnutrition (HP:0004395)2.08750526
93Bone cyst (HP:0012062)2.07096529
94Abnormal vertebral ossification (HP:0100569)2.06802048
95Hypoplasia of the odontoid process (HP:0003311)2.06514163
96Hip contracture (HP:0003273)2.04994285
97Type II lissencephaly (HP:0007260)2.04641214
98Aplasia/Hypoplasia of the hallux (HP:0008362)2.03680735
99Distal lower limb amyotrophy (HP:0008944)2.01821740
100Ureteral obstruction (HP:0006000)2.00845193
101Muscle hypertrophy of the lower extremities (HP:0008968)2.00699130
102Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00548498
103Abnormality of polysaccharide metabolism (HP:0011012)2.00548498
104Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00548498
105Hyperglycinuria (HP:0003108)2.00464494
106Short femoral neck (HP:0100864)1.98661381
107Biliary tract neoplasm (HP:0100574)1.98206519
108Short 1st metacarpal (HP:0010034)1.97524868
109Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.97524868
110Abnormality of proline metabolism (HP:0010907)1.97406471
111Hydroxyprolinuria (HP:0003080)1.97406471
112Mucopolysacchariduria (HP:0008155)1.96615092
113Urinary glycosaminoglycan excretion (HP:0003541)1.96615092
114Abnormal biliary tract morphology (HP:0012440)1.96389176
115Neck muscle weakness (HP:0000467)1.95760837
116Nephronophthisis (HP:0000090)1.94529161
117True hermaphroditism (HP:0010459)1.93990239
118Muscle fiber splitting (HP:0003555)1.92046623
119Abnormality of the 2nd finger (HP:0004100)1.92038069
120Decreased circulating renin level (HP:0003351)1.91519559
121Congenital stationary night blindness (HP:0007642)1.91463507
122Abnormality of potassium homeostasis (HP:0011042)1.91158909
123Fatigable weakness (HP:0003473)1.91086010
124Abnormality of the neuromuscular junction (HP:0003398)1.91086010
125Abnormality of carpal bone ossification (HP:0006257)1.90822255
126Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.90590230
127Exercise-induced muscle cramps (HP:0003710)1.90321765
128Short middle phalanx of finger (HP:0005819)1.90150083
129Facial diplegia (HP:0001349)1.89352829
130Hamartoma of the eye (HP:0010568)1.88264452
131Frequent falls (HP:0002359)1.88153193
132Hyperventilation (HP:0002883)1.88129432
133Muscle fiber inclusion bodies (HP:0100299)1.87833268
134Abnormality of the renal medulla (HP:0100957)1.87302269
135Broad face (HP:0000283)1.87124751
136Myoglobinuria (HP:0002913)1.86369992
137Hypokalemia (HP:0002900)1.83704283
138Abnormality of the vitamin B12 metabolism (HP:0004341)1.83389251
139Atrial fibrillation (HP:0005110)1.83303096
140Aortic aneurysm (HP:0004942)1.83184046
141Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.83053442
142Abnormality of vitamin B metabolism (HP:0004340)1.82740485
143Joint stiffness (HP:0001387)1.82733200
144Delayed CNS myelination (HP:0002188)1.82244376
145Abnormality of the renal cortex (HP:0011035)1.81329392
146Furrowed tongue (HP:0000221)1.80489539
147Aortic dissection (HP:0002647)1.80229907
148Abnormality of the aortic arch (HP:0012303)1.80015919
149EMG: myopathic abnormalities (HP:0003458)1.79546406
150Abnormal finger flexion creases (HP:0006143)1.77880919
151Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77690035
152Vertebral hypoplasia (HP:0008417)1.77690035
153Abnormality of the phalanges of the hallux (HP:0010057)1.76461425
154Bronchomalacia (HP:0002780)1.75929159
155Abnormal hand bone ossification (HP:0010660)1.75894219
156Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75507521
157Urethral obstruction (HP:0000796)1.75327470
158Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75325780
159Dicarboxylic aciduria (HP:0003215)1.75325780
160Severe muscular hypotonia (HP:0006829)1.75071641
161Abnormality of the vitreous humor (HP:0004327)1.74238883
162Severe Myopia (HP:0011003)1.72247677
163Pigmentary retinal degeneration (HP:0001146)1.71513025
164Abnormality of the femoral head (HP:0003368)1.71506704
165Clumsiness (HP:0002312)1.71223089
166Obstructive sleep apnea (HP:0002870)1.71221456
167Molar tooth sign on MRI (HP:0002419)1.67674296
168Abnormality of midbrain morphology (HP:0002418)1.67674296
169Aplasia of the musculature (HP:0100854)1.67477324
170Enlarged epiphyses (HP:0010580)1.66076948
171Shawl scrotum (HP:0000049)1.64877613
172Congenital, generalized hypertrichosis (HP:0004540)1.64620365
173Hemorrhage of the eye (HP:0011885)1.63187064
174Stage 5 chronic kidney disease (HP:0003774)1.63182897
175Abnormality of the odontoid process (HP:0003310)1.62894543
176Occipital encephalocele (HP:0002085)1.62426824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.43628930
2MST1R3.68567333
3FRK3.63682495
4NME12.88025237
5ACVR1B2.87162746
6RIPK12.79813940
7PIK3CA2.76036302
8TTN2.74840919
9EPHA22.57928770
10MST42.24105978
11ADRBK22.21836130
12MAP2K22.15141120
13MYLK2.13684931
14DMPK2.04941461
15GRK12.04216701
16PRKG21.88873795
17PTK61.82062246
18AKT31.81073775
19EPHB21.80643042
20LATS11.79266644
21DDR21.78176810
22PDGFRA1.70727176
23IRAK31.67273481
24FER1.60867092
25OBSCN1.58417198
26TESK11.57013042
27MET1.55746623
28ERN11.38352975
29ZAK1.35560267
30PDK21.30793768
31STK391.29496229
32MAP3K21.29382767
33MUSK1.27094011
34PTK21.17100243
35FGFR41.15244576
36INSRR1.13945574
37PINK11.12602533
38CDC42BPA1.11369013
39TNK21.05663326
40TRPM71.05512452
41PRKCI1.02107552
42IKBKE1.01819930
43MATK1.00443092
44MAP3K140.99102726
45PDK30.98890720
46PDK40.98890720
47MAP4K20.96496674
48STK240.95573044
49MAP3K30.93792921
50MAP2K10.93039199
51EPHA30.89912649
52ICK0.88625548
53MAP3K100.88362626
54RPS6KB20.88318582
55ADRBK10.88100414
56PTK2B0.85930673
57BMPR1B0.83642487
58TAOK10.83562277
59TIE10.83046591
60SIK10.82986973
61TYK20.82563086
62RPS6KA60.82158013
63PDGFRB0.81680695
64OXSR10.80381188
65TLK10.79465565
66STK38L0.79103039
67PHKG10.78622822
68PHKG20.78622822
69RIPK40.77569538
70MAP2K60.76864184
71MAP3K110.75827511
72NUAK10.73946293
73JAK10.72624733
74TBK10.72258400
75JAK30.71955238
76CAMK1D0.71775276
77MARK20.71098165
78TRIB30.69423154
79EPHB10.69414248
80DAPK20.69304895
81MAP3K70.69002616
82CSK0.68740192
83CDK120.68638055
84PIK3CG0.68628707
85PAK40.66529679
86PRKD10.66069638
87CHUK0.65652159
88PRKAA20.65553139
89WNK40.65281293
90RPS6KL10.65220285
91RPS6KC10.65220285
92MAP3K60.64688710
93TAOK30.64481059
94PRKD30.64242920
95MAP3K10.64118277
96MAPK150.62980840
97FLT30.62282435
98BMX0.60179621
99ERBB20.57260775
100MAPK130.55956372
101FGFR30.54016560
102CAMK2D0.50043986
103PAK30.49073747
104STK30.48308622
105TTK0.46735168
106MAPKAPK30.46601545
107MTOR0.46263323
108PDPK10.45915953
109ROCK10.45585360
110RPS6KA20.45142787
111PKN20.43002743
112ABL20.41737252
113IKBKB0.41384578
114PRKCZ0.41366608
115LIMK10.40992062
116PRKAA10.40699071
117CAMK10.40189857
118NEK90.39723505
119IRAK10.39314247
120PRKD20.38821869
121STK100.38408859
122EEF2K0.38288509
123CAMK1G0.34868632
124PRKCE0.34165582
125* PRKCA0.33102181
126MAP3K120.32008581
127MAPK80.31859735
128PRKACA0.31785007
129ILK0.31676254
130MAPK110.31442493
131SGK30.31065271
132MAPK70.29939276
133PDK10.29838144
134TGFBR20.29501123
135PIM20.29492529
136CAMK2G0.29413486
137STK380.28973963
138MAPKAPK20.28388814
139TGFBR10.27963745

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.16867093
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.73534911
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.67251351
4Fat digestion and absorption_Homo sapiens_hsa049753.36699468
5Mineral absorption_Homo sapiens_hsa049783.32621314
6Renin-angiotensin system_Homo sapiens_hsa046142.60033097
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.47653413
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31966064
9Galactose metabolism_Homo sapiens_hsa000522.23474463
10Protein digestion and absorption_Homo sapiens_hsa049742.22953754
11Nitrogen metabolism_Homo sapiens_hsa009102.13969855
12Fructose and mannose metabolism_Homo sapiens_hsa000511.77470661
13Chemical carcinogenesis_Homo sapiens_hsa052041.76219217
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.71819058
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68516368
16Tryptophan metabolism_Homo sapiens_hsa003801.68111059
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.67460366
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67222606
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66303263
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.65995436
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56410371
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50943763
23Retinol metabolism_Homo sapiens_hsa008301.47874862
24Caffeine metabolism_Homo sapiens_hsa002321.45795624
25Tight junction_Homo sapiens_hsa045301.45345489
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44722945
27Pancreatic secretion_Homo sapiens_hsa049721.42412148
28Vitamin digestion and absorption_Homo sapiens_hsa049771.42354277
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42005314
30Starch and sucrose metabolism_Homo sapiens_hsa005001.39642723
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.37982480
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.36063789
33Adherens junction_Homo sapiens_hsa045201.32933828
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30473193
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.29623248
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29531132
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26276551
38ECM-receptor interaction_Homo sapiens_hsa045121.25898883
39Arginine and proline metabolism_Homo sapiens_hsa003301.25013338
40Linoleic acid metabolism_Homo sapiens_hsa005911.21733445
41Dilated cardiomyopathy_Homo sapiens_hsa054141.17499632
42Butanoate metabolism_Homo sapiens_hsa006501.08187238
43Sulfur relay system_Homo sapiens_hsa041221.08080359
44Arachidonic acid metabolism_Homo sapiens_hsa005901.05330747
45Arginine biosynthesis_Homo sapiens_hsa002201.02988816
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98606498
47Sphingolipid metabolism_Homo sapiens_hsa006000.98320285
48Toxoplasmosis_Homo sapiens_hsa051450.98139635
49Ovarian steroidogenesis_Homo sapiens_hsa049130.97989156
50Salmonella infection_Homo sapiens_hsa051320.95280409
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.94824126
52Influenza A_Homo sapiens_hsa051640.92349141
53Amoebiasis_Homo sapiens_hsa051460.92246287
54Phenylalanine metabolism_Homo sapiens_hsa003600.89960195
55Focal adhesion_Homo sapiens_hsa045100.88180746
56Peroxisome_Homo sapiens_hsa041460.87093733
57Cardiac muscle contraction_Homo sapiens_hsa042600.85241674
58* Insulin secretion_Homo sapiens_hsa049110.84038178
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82986885
60Tyrosine metabolism_Homo sapiens_hsa003500.81322433
61Bladder cancer_Homo sapiens_hsa052190.81282514
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80391069
63Type II diabetes mellitus_Homo sapiens_hsa049300.79176720
64Taste transduction_Homo sapiens_hsa047420.78243842
65Bile secretion_Homo sapiens_hsa049760.77800683
66Hepatitis C_Homo sapiens_hsa051600.77778679
67Phototransduction_Homo sapiens_hsa047440.77681289
68Vibrio cholerae infection_Homo sapiens_hsa051100.77031807
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77031142
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.76859441
71Fatty acid biosynthesis_Homo sapiens_hsa000610.76797979
72Other glycan degradation_Homo sapiens_hsa005110.74941165
73Leishmaniasis_Homo sapiens_hsa051400.73378263
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.72716692
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70190157
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69782347
77Insulin resistance_Homo sapiens_hsa049310.67442615
78TNF signaling pathway_Homo sapiens_hsa046680.66773620
79Renin secretion_Homo sapiens_hsa049240.65952970
80Glycerolipid metabolism_Homo sapiens_hsa005610.65583254
81Serotonergic synapse_Homo sapiens_hsa047260.65537808
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.64259713
83Small cell lung cancer_Homo sapiens_hsa052220.64112819
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63512862
85Notch signaling pathway_Homo sapiens_hsa043300.62976858
86Cocaine addiction_Homo sapiens_hsa050300.62607786
87Viral myocarditis_Homo sapiens_hsa054160.62374474
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61345370
89Gastric acid secretion_Homo sapiens_hsa049710.61330219
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61071450
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.61014491
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59413973
93Legionellosis_Homo sapiens_hsa051340.58689654
94beta-Alanine metabolism_Homo sapiens_hsa004100.58304300
95Folate biosynthesis_Homo sapiens_hsa007900.56440280
96Proteoglycans in cancer_Homo sapiens_hsa052050.55440079
97Axon guidance_Homo sapiens_hsa043600.54691761
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54645443
99Pertussis_Homo sapiens_hsa051330.52101924
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.52006150
101Prolactin signaling pathway_Homo sapiens_hsa049170.50982645
102Fatty acid metabolism_Homo sapiens_hsa012120.50372053
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49791150
104Histidine metabolism_Homo sapiens_hsa003400.49147447
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49063189
106Lysosome_Homo sapiens_hsa041420.47510930
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.46638013
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46526757
109HIF-1 signaling pathway_Homo sapiens_hsa040660.46400529
110Collecting duct acid secretion_Homo sapiens_hsa049660.46388303
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45543947
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45521266
113Glutathione metabolism_Homo sapiens_hsa004800.45209515
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45160163
115Alzheimers disease_Homo sapiens_hsa050100.44651129
116PPAR signaling pathway_Homo sapiens_hsa033200.44551860
117Tuberculosis_Homo sapiens_hsa051520.43972478
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.42803195
119Lysine degradation_Homo sapiens_hsa003100.42650115
120ABC transporters_Homo sapiens_hsa020100.42392794
121Calcium signaling pathway_Homo sapiens_hsa040200.42253604
122Metabolic pathways_Homo sapiens_hsa011000.41899746
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41652045
124Osteoclast differentiation_Homo sapiens_hsa043800.40912291
125Inositol phosphate metabolism_Homo sapiens_hsa005620.40898964
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40671391
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40667356
128AMPK signaling pathway_Homo sapiens_hsa041520.40487418
129Hippo signaling pathway_Homo sapiens_hsa043900.39944044
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39488211
131Salivary secretion_Homo sapiens_hsa049700.39400705
132Choline metabolism in cancer_Homo sapiens_hsa052310.39162269
133GnRH signaling pathway_Homo sapiens_hsa049120.38918662
134Fatty acid degradation_Homo sapiens_hsa000710.37940769
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37826674
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37615802
137Basal cell carcinoma_Homo sapiens_hsa052170.37286628
138African trypanosomiasis_Homo sapiens_hsa051430.36934919
139Hematopoietic cell lineage_Homo sapiens_hsa046400.36530543
140Apoptosis_Homo sapiens_hsa042100.35854980
141Selenocompound metabolism_Homo sapiens_hsa004500.35405522
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35250138
143VEGF signaling pathway_Homo sapiens_hsa043700.34660340
144Thyroid hormone synthesis_Homo sapiens_hsa049180.34035971
145Dorso-ventral axis formation_Homo sapiens_hsa043200.33573181
146Insulin signaling pathway_Homo sapiens_hsa049100.33234853
147Glucagon signaling pathway_Homo sapiens_hsa049220.33065261
148TGF-beta signaling pathway_Homo sapiens_hsa043500.32633977
149Ether lipid metabolism_Homo sapiens_hsa005650.32584322
150Circadian entrainment_Homo sapiens_hsa047130.30127031
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29403210
152Glutamatergic synapse_Homo sapiens_hsa047240.27886699

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