TRPM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.34916873
2nuclear pore complex assembly (GO:0051292)5.04746618
3nuclear pore organization (GO:0006999)4.92040426
4regulation of establishment of cell polarity (GO:2000114)4.66572441
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.63319574
6cellular response to ethanol (GO:0071361)4.58962083
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.56073929
8negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.20142944
9positive regulation of immune response to tumor cell (GO:0002839)4.16693619
10regulation of immune response to tumor cell (GO:0002837)4.16693619
11regulation of response to tumor cell (GO:0002834)4.16693619
12positive regulation of response to tumor cell (GO:0002836)4.16693619
13definitive hemopoiesis (GO:0060216)4.01585189
14regulation of DNA endoreduplication (GO:0032875)3.98824880
15regulation of establishment or maintenance of cell polarity (GO:0032878)3.96512785
16pore complex assembly (GO:0046931)3.95724409
17hepatocyte apoptotic process (GO:0097284)3.79207823
18protein K48-linked deubiquitination (GO:0071108)3.73798608
19mitotic chromosome condensation (GO:0007076)3.71594227
20proline biosynthetic process (GO:0006561)3.61121141
21regulation of histone H3-K27 methylation (GO:0061085)3.55890436
22regulation of clathrin-mediated endocytosis (GO:2000369)3.54539287
23protein prenylation (GO:0018342)3.54316380
24prenylation (GO:0097354)3.54316380
25intestinal epithelial cell development (GO:0060576)3.53233593
26monoubiquitinated protein deubiquitination (GO:0035520)3.51201178
27regulation of pigment cell differentiation (GO:0050932)3.49570885
28cytoplasmic mRNA processing body assembly (GO:0033962)3.49498576
29establishment of protein localization to Golgi (GO:0072600)3.45839612
30positive regulation of developmental pigmentation (GO:0048087)3.45682460
31lymphoid progenitor cell differentiation (GO:0002320)3.44822450
32positive regulation of mitotic sister chromatid separation (GO:1901970)3.41549636
33positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.41549636
34positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.41549636
35response to pheromone (GO:0019236)3.40731176
36lipid translocation (GO:0034204)3.37537186
37phospholipid translocation (GO:0045332)3.37537186
38histone-serine phosphorylation (GO:0035404)3.37418172
39meiotic chromosome segregation (GO:0045132)3.36961446
40histone H3-K9 demethylation (GO:0033169)3.32677837
41negative regulation of histone methylation (GO:0031061)3.27090544
42early endosome to late endosome transport (GO:0045022)3.26564060
43protein K11-linked deubiquitination (GO:0035871)3.24962516
44fatty acid transmembrane transport (GO:1902001)3.22876213
45prostate gland growth (GO:0060736)3.18611265
46histone H3-K36 demethylation (GO:0070544)3.15671246
47negative regulation of DNA-dependent DNA replication (GO:2000104)3.13473905
48kinetochore organization (GO:0051383)3.13356393
49positive regulation of DNA-templated transcription, initiation (GO:2000144)3.13239104
50snRNA transcription (GO:0009301)3.10646646
51dosage compensation (GO:0007549)3.10260581
52DNA unwinding involved in DNA replication (GO:0006268)3.09445486
53translesion synthesis (GO:0019985)3.07120736
54histone H3-K9 methylation (GO:0051567)3.04830437
55regulation of protein polyubiquitination (GO:1902914)3.04425422
56TOR signaling (GO:0031929)3.03567627
57carnitine shuttle (GO:0006853)3.02616609
58regulation of histone H3-K9 methylation (GO:0051570)3.01244789
59DNA geometric change (GO:0032392)3.00773317
60UDP-N-acetylglucosamine metabolic process (GO:0006047)3.00597496
61rRNA catabolic process (GO:0016075)3.00480872
62regulation of histone H3-K4 methylation (GO:0051569)2.98712800
63positive regulation by host of viral transcription (GO:0043923)2.98426449
64reciprocal meiotic recombination (GO:0007131)2.98295978
65reciprocal DNA recombination (GO:0035825)2.98295978
66DNA topological change (GO:0006265)2.97427066
67DNA duplex unwinding (GO:0032508)2.95471380
68positive regulation of translational initiation (GO:0045948)2.93269483
69regulation of RNA export from nucleus (GO:0046831)2.92411713
70striated muscle atrophy (GO:0014891)2.91724593
71N-terminal protein amino acid acetylation (GO:0006474)2.91283337
72histone H3-K9 modification (GO:0061647)2.90681193
73sister chromatid cohesion (GO:0007062)2.89337530
74protein targeting to Golgi (GO:0000042)2.86428729
75Golgi to endosome transport (GO:0006895)2.86207340
76regulation of sister chromatid cohesion (GO:0007063)2.83573797
77iron ion import (GO:0097286)2.82743691
78negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82360365
79negative regulation of translation, ncRNA-mediated (GO:0040033)2.82360365
80regulation of translation, ncRNA-mediated (GO:0045974)2.82360365
81positive regulation of histone methylation (GO:0031062)2.78861030
82sister chromatid segregation (GO:0000819)2.78838322
83retrograde transport, vesicle recycling within Golgi (GO:0000301)2.78702215
84magnesium ion transport (GO:0015693)2.76735874
85mitotic nuclear envelope disassembly (GO:0007077)2.74949769
86protein localization to kinetochore (GO:0034501)2.74841583
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.72416203
88carnitine transmembrane transport (GO:1902603)2.71100274
89glucocorticoid receptor signaling pathway (GO:0042921)2.68397767
90regulation of centrosome cycle (GO:0046605)2.67173787
91intracellular lipid transport (GO:0032365)2.66217303
92carnitine transport (GO:0015879)2.65433493
93amino-acid betaine transport (GO:0015838)2.65433493
94regulation of spindle organization (GO:0090224)2.65396116
95nuclear envelope disassembly (GO:0051081)2.63655366
96membrane disassembly (GO:0030397)2.63655366
97negative regulation by host of viral transcription (GO:0043922)2.61503639
98replication fork processing (GO:0031297)2.60962682
99regulation of mitotic spindle organization (GO:0060236)2.60877652
100regulation of nuclear cell cycle DNA replication (GO:0033262)2.59227034
101regulation of hippo signaling (GO:0035330)2.58301342
102embryonic hemopoiesis (GO:0035162)2.57976286
103metaphase plate congression (GO:0051310)2.57600684
104fibroblast migration (GO:0010761)2.57478408
105signal peptide processing (GO:0006465)2.56269475
106synapsis (GO:0007129)2.56164741
107skeletal muscle adaptation (GO:0043501)2.54612817
108oocyte development (GO:0048599)2.53109227
109mitotic metaphase plate congression (GO:0007080)2.52576648
110poly(A)+ mRNA export from nucleus (GO:0016973)2.52000113
111DNA conformation change (GO:0071103)2.51763657
112regulation of centriole replication (GO:0046599)2.51124552
113positive regulation of mRNA catabolic process (GO:0061014)2.50929596
114kynurenine metabolic process (GO:0070189)2.50847920
115histone mRNA catabolic process (GO:0071044)2.50716685
116histone lysine demethylation (GO:0070076)2.50417226
117regulation of energy homeostasis (GO:2000505)2.50315169
118protein K6-linked ubiquitination (GO:0085020)2.49893478
119uterus development (GO:0060065)2.49670701
120corticosteroid receptor signaling pathway (GO:0031958)2.49206903
121positive regulation of natural killer cell activation (GO:0032816)2.48702362
122ketone body metabolic process (GO:1902224)2.48107513
123mitotic recombination (GO:0006312)2.47594295
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47213897
125inner cell mass cell proliferation (GO:0001833)2.47126685
126histone demethylation (GO:0016577)2.47029761
127double-strand break repair via homologous recombination (GO:0000724)2.45790722
128nucleus localization (GO:0051647)2.45541706
129DNA synthesis involved in DNA repair (GO:0000731)2.44847952
130positive regulation of chromosome segregation (GO:0051984)2.44657010
131protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.43527235
132regulation of transforming growth factor beta2 production (GO:0032909)2.43510594
133peptidyl-lysine methylation (GO:0018022)2.43187337
134positive regulation of granulocyte differentiation (GO:0030854)2.42984894
135embryonic process involved in female pregnancy (GO:0060136)2.41886190
136positive regulation of protein import into nucleus, translocation (GO:0033160)2.39474688
137histone H3-K4 trimethylation (GO:0080182)2.39100272
138chromatin assembly (GO:0031497)2.38252520
139resolution of meiotic recombination intermediates (GO:0000712)2.35995553
140nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.34379317
141negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.32879213
142regulation of nucleobase-containing compound transport (GO:0032239)2.29597696
143positive regulation of respiratory burst (GO:0060267)2.27665267
144negative regulation of DNA repair (GO:0045738)2.27623816
145protein localization to chromosome, centromeric region (GO:0071459)2.27567963
146chromatin remodeling at centromere (GO:0031055)2.26806735
147CENP-A containing nucleosome assembly (GO:0034080)2.26569270
148attachment of spindle microtubules to kinetochore (GO:0008608)2.25621524
149replicative senescence (GO:0090399)2.24748336
150peptidyl-lysine trimethylation (GO:0018023)2.24063523
151negative regulation of chromatin modification (GO:1903309)2.22923693
152negative regulation of histone modification (GO:0031057)2.22903602
153regulation of chromatin silencing (GO:0031935)2.22061551
154intra-S DNA damage checkpoint (GO:0031573)2.20596624
155chromosome condensation (GO:0030261)2.20313429
156regulation of mitotic metaphase/anaphase transition (GO:0030071)2.20086443
157positive regulation of histone H3-K4 methylation (GO:0051571)2.19341408
158myoblast migration (GO:0051451)2.18791358
159insulin-like growth factor receptor signaling pathway (GO:0048009)2.18748402
160DNA replication-independent nucleosome assembly (GO:0006336)2.18037453
161DNA replication-independent nucleosome organization (GO:0034724)2.18037453
162regulation of DNA-dependent DNA replication (GO:0090329)2.17959877
163growth hormone receptor signaling pathway (GO:0060396)2.17727489
164DNA packaging (GO:0006323)2.17536967
165regulation of centrosome duplication (GO:0010824)2.17124880
166interkinetic nuclear migration (GO:0022027)2.17052505
167mitotic DNA integrity checkpoint (GO:0044774)2.16708914
168DNA replication checkpoint (GO:0000076)2.14874897
169positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.14620188
170IMP biosynthetic process (GO:0006188)2.14588746
171telomere maintenance via recombination (GO:0000722)2.14553833
172positive regulation of gamma-delta T cell activation (GO:0046645)2.14216105
173positive regulation of natural killer cell differentiation (GO:0032825)2.13801904
174histone H3-K4 methylation (GO:0051568)2.13366814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.04178802
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.75233049
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.58862673
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.55989539
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34697705
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.90552159
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81738847
8GATA1_22025678_ChIP-Seq_K562_Human2.64071108
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.56066473
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.48132017
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.40974877
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.38616797
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37876314
14AR_21909140_ChIP-Seq_LNCAP_Human2.22792594
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19349358
16* ER_23166858_ChIP-Seq_MCF-7_Human2.17747267
17* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.11850240
18E2F7_22180533_ChIP-Seq_HELA_Human10.4093291
19AHR_22903824_ChIP-Seq_MCF-7_Human1.99038919
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98926005
21GBX2_23144817_ChIP-Seq_PC3_Human1.95136694
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.92910525
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91489993
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.89960620
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85208420
26FOXM1_26456572_ChIP-Seq_MCF-7_Human1.84649411
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79689920
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78414504
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75817306
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74389353
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70832766
32ZNF274_21170338_ChIP-Seq_K562_Hela1.70456232
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68409397
34ARNT_22903824_ChIP-Seq_MCF-7_Human1.68387923
35TAF15_26573619_Chip-Seq_HEK293_Human1.67644258
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66574194
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.66182975
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65754602
39VDR_22108803_ChIP-Seq_LS180_Human1.63675987
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63520952
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63042925
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.60647993
43* STAT3_23295773_ChIP-Seq_U87_Human1.59074478
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56149553
45TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.54346087
46ELK1_19687146_ChIP-ChIP_HELA_Human1.54171375
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51206455
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50857015
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47881733
50IGF1R_20145208_ChIP-Seq_DFB_Human1.47294191
51CLOCK_20551151_ChIP-Seq_293T_Human1.44883024
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43832509
53P300_19829295_ChIP-Seq_ESCs_Human1.43349993
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41493566
55* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41158008
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40779730
57BRD4_25478319_ChIP-Seq_HGPS_Human1.39684129
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.38743183
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38724748
60* TCF4_23295773_ChIP-Seq_U87_Human1.37854081
61SMAD4_21799915_ChIP-Seq_A2780_Human1.37795209
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37485035
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37243654
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37243654
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37219374
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36408263
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34302722
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34302722
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32948981
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.32616539
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32222349
72BCAT_22108803_ChIP-Seq_LS180_Human1.31508673
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30719551
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29685563
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28553402
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28040078
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27860104
78SCL_19346495_ChIP-Seq_HPC-7_Human1.26014938
79EWS_26573619_Chip-Seq_HEK293_Human1.25853921
80IRF8_21731497_ChIP-ChIP_J774_Mouse1.25233043
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25185340
82* E2F1_18555785_Chip-Seq_ESCs_Mouse1.24678946
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24287599
84MYB_26560356_Chip-Seq_TH2_Human1.23849297
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.23848874
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23673278
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.22079181
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21114709
89NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21014530
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19499211
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19437328
92IRF8_27001747_Chip-Seq_BMDM_Mouse1.19202280
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.17982054
94MYB_26560356_Chip-Seq_TH1_Human1.17757777
95P53_22387025_ChIP-Seq_ESCs_Mouse1.17673400
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.17053261
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.17018882
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.16651436
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16650696
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15903441
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15287668
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14718870
103* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13827284
104* RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11871697
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11749754
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09553128
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09282011
108* CMYC_18555785_Chip-Seq_ESCs_Mouse1.09267911
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09141958
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08533719
111* P300_18555785_Chip-Seq_ESCs_Mouse1.08323717
112BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08308313
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07855167
114CBP_20019798_ChIP-Seq_JUKART_Human1.07855167
115NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06635392
116TP53_16413492_ChIP-PET_HCT116_Human1.04472757
117OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04426889
118RUNX_20019798_ChIP-Seq_JUKART_Human1.03672033
119TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03509232
120TFEB_21752829_ChIP-Seq_HELA_Human1.03214279
121FOXO3_23340844_ChIP-Seq_DLD1_Human1.03092418
122PU_27001747_Chip-Seq_BMDM_Mouse1.02946521
123* OCT4_18555785_Chip-Seq_ESCs_Mouse1.02301172
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02037079
125TCF4_22108803_ChIP-Seq_LS180_Human1.01933274
126* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01351917
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01002014
128AR_25329375_ChIP-Seq_VCAP_Human1.00739098
129* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00728827
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.99260097
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98773847
132MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97915979
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97662508
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97016230
135MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96727597
136* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96700914
137CJUN_26792858_Chip-Seq_BT549_Human0.96437379
138MYC_22102868_ChIP-Seq_BL_Human0.94767288
139RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93620210
140HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93529088
141GATA4_21415370_ChIP-Seq_HL-1_Mouse0.93329027
142POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87019526
143CIITA_25753668_ChIP-Seq_RAJI_Human0.85385834
144SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84608632
145SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84292117
146EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84045468
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82975537
148BP1_19119308_ChIP-ChIP_Hs578T_Human0.82718489
149* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81455273
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80357528
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78925863
152* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78916362
153SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78740285
154SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78380968
155FUS_26573619_Chip-Seq_HEK293_Human0.77844161
156TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76902926
157* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.76831194
158FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.75936900
159SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75894718
160RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75653698
161PKCTHETA_26484144_Chip-Seq_BREAST_Human0.74790457
162TP63_17297297_ChIP-ChIP_HaCaT_Human0.74300811
163SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74256270
164TRIM28_21343339_ChIP-Seq_HEK293_Human0.72799006
165ESR1_21235772_ChIP-Seq_MCF-7_Human0.72699916
166ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.72549209
167PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.72545040
168CDX2_22108803_ChIP-Seq_LS180_Human0.71808814
169* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.71242783
170MAF_26560356_Chip-Seq_TH1_Human0.70956028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.43497407
2MP0008438_abnormal_cutaneous_collagen3.01509346
3MP0000427_abnormal_hair_cycle2.98199846
4MP0010352_gastrointestinal_tract_polyps2.74525637
5MP0010678_abnormal_skin_adnexa2.69774809
6MP0002009_preneoplasia2.60898936
7MP0005503_abnormal_tendon_morphology2.44416495
8MP0003705_abnormal_hypodermis_morpholog2.43125875
9MP0008057_abnormal_DNA_replication2.38288601
10MP0010307_abnormal_tumor_latency2.35139758
11MP0002166_altered_tumor_susceptibility2.28070157
12MP0010094_abnormal_chromosome_stability2.16150457
13MP0002396_abnormal_hematopoietic_system2.09781161
14MP0004264_abnormal_extraembryonic_tissu1.85086703
15MP0003195_calcinosis1.83711875
16MP0005275_abnormal_skin_tensile1.82933402
17MP0002006_tumorigenesis1.80256323
18MP0003111_abnormal_nucleus_morphology1.78701963
19MP0004808_abnormal_hematopoietic_stem1.76278317
20MP0005075_abnormal_melanosome_morpholog1.74313483
21MP0010234_abnormal_vibrissa_follicle1.73081202
22MP0003300_gastrointestinal_ulcer1.72631015
23MP0003566_abnormal_cell_adhesion1.70670771
24MP0008007_abnormal_cellular_replicative1.70428538
25MP0003077_abnormal_cell_cycle1.67628226
26MP0004381_abnormal_hair_follicle1.59311385
27MP0006054_spinal_hemorrhage1.53718641
28MP0003656_abnormal_erythrocyte_physiolo1.50644111
29MP0000372_irregular_coat_pigmentation1.50104440
30MP0002877_abnormal_melanocyte_morpholog1.49240743
31MP0002160_abnormal_reproductive_system1.49031364
32MP0005076_abnormal_cell_differentiation1.44331870
33MP0003252_abnormal_bile_duct1.34619156
34MP0003121_genomic_imprinting1.33609759
35MP0003567_abnormal_fetal_cardiomyocyte1.30456503
36MP0002060_abnormal_skin_morphology1.30100283
37MP0003091_abnormal_cell_migration1.28063907
38MP0003941_abnormal_skin_development1.26467864
39MP0001915_intracranial_hemorrhage1.25405150
40MP0003787_abnormal_imprinting1.24656324
41MP0005023_abnormal_wound_healing1.23459168
42MP0002086_abnormal_extraembryonic_tissu1.21727461
43MP0009278_abnormal_bone_marrow1.20697647
44MP0004145_abnormal_muscle_electrophysio1.20677356
45MP0001545_abnormal_hematopoietic_system1.19474857
46MP0005397_hematopoietic_system_phenotyp1.19474857
47MP0000733_abnormal_muscle_development1.17997702
48MP0002075_abnormal_coat/hair_pigmentati1.17926944
49MP0002876_abnormal_thyroid_physiology1.16001607
50MP0004197_abnormal_fetal_growth/weight/1.15996449
51MP0003950_abnormal_plasma_membrane1.15407123
52MP0005646_abnormal_pituitary_gland1.15181469
53MP0003984_embryonic_growth_retardation1.15178925
54MP0002088_abnormal_embryonic_growth/wei1.13452410
55MP0001958_emphysema1.13343381
56MP0000350_abnormal_cell_proliferation1.12680268
57MP0005220_abnormal_exocrine_pancreas1.12152529
58MP0001661_extended_life_span1.11136230
59MP0002928_abnormal_bile_duct1.09967753
60MP0008877_abnormal_DNA_methylation1.09372608
61MP0009703_decreased_birth_body1.09242124
62MP0008058_abnormal_DNA_repair1.09015684
63MP0000371_diluted_coat_color1.08998361
64MP0001672_abnormal_embryogenesis/_devel1.08868945
65MP0005380_embryogenesis_phenotype1.08868945
66MP0005171_absent_coat_pigmentation1.07990375
67MP0009780_abnormal_chondrocyte_physiolo1.07680498
68MP0000015_abnormal_ear_pigmentation1.07589958
69MP0009053_abnormal_anal_canal1.07169243
70MP0004484_altered_response_of1.06976872
71MP0003935_abnormal_craniofacial_develop1.06498945
72MP0002254_reproductive_system_inflammat1.05824878
73MP0000432_abnormal_head_morphology1.03106356
74MP0003943_abnormal_hepatobiliary_system1.01338525
75MP0001879_abnormal_lymphatic_vessel1.01315495
76MP0002108_abnormal_muscle_morphology1.01095006
77MP0005389_reproductive_system_phenotype1.00468586
78MP0003693_abnormal_embryo_hatching1.00022977
79MP0002138_abnormal_hepatobiliary_system0.98898291
80MP0001873_stomach_inflammation0.98179059
81MP0002139_abnormal_hepatobiliary_system0.97059950
82MP0003763_abnormal_thymus_physiology0.96101178
83MP0004272_abnormal_basement_membrane0.95925555
84MP0004883_abnormal_blood_vessel0.95836070
85MP0004957_abnormal_blastocyst_morpholog0.95338967
86MP0003279_aneurysm0.94817045
87MP0002168_other_aberrant_phenotype0.94137660
88MP0008775_abnormal_heart_ventricle0.93608718
89MP0004084_abnormal_cardiac_muscle0.92683407
90MP0000516_abnormal_urinary_system0.92022862
91MP0005367_renal/urinary_system_phenotyp0.92022862
92MP0001835_abnormal_antigen_presentation0.91872309
93MP0000767_abnormal_smooth_muscle0.91511910
94MP0003890_abnormal_embryonic-extraembry0.90999701
95MP0005310_abnormal_salivary_gland0.90968002
96MP0004134_abnormal_chest_morphology0.90882243
97MP0010368_abnormal_lymphatic_system0.89564132
98MP0003315_abnormal_perineum_morphology0.87928191
99MP0005508_abnormal_skeleton_morphology0.87471502
100MP0009697_abnormal_copulation0.87469790
101MP0005645_abnormal_hypothalamus_physiol0.87466839
102MP0002925_abnormal_cardiovascular_devel0.86400447
103MP0010386_abnormal_urinary_bladder0.86118297
104MP0001730_embryonic_growth_arrest0.86094281
105MP0003045_fibrosis0.85940572
106MP0003123_paternal_imprinting0.85382966
107MP0002095_abnormal_skin_pigmentation0.82863677
108MP0008995_early_reproductive_senescence0.82843485
109MP0002084_abnormal_developmental_patter0.81909113
110MP0001186_pigmentation_phenotype0.81308790
111MP0001697_abnormal_embryo_size0.81025133
112MP0001243_abnormal_dermal_layer0.80396591
113MP0004036_abnormal_muscle_relaxation0.79854549
114MP0000470_abnormal_stomach_morphology0.79641730
115MP0005408_hypopigmentation0.79335600
116MP0003646_muscle_fatigue0.78609775
117MP0002837_dystrophic_cardiac_calcinosis0.78586603
118MP0005647_abnormal_sex_gland0.78056094
119MP0004147_increased_porphyrin_level0.77937220
120MP0009672_abnormal_birth_weight0.77698518
121MP0004215_abnormal_myocardial_fiber0.77502361
122MP0000377_abnormal_hair_follicle0.77476291
123MP0005257_abnormal_intraocular_pressure0.77092349
124MP0000703_abnormal_thymus_morphology0.76769359
125MP0002115_abnormal_skeleton_extremities0.76144606
126MP0009384_cardiac_valve_regurgitation0.75849940
127MP0003868_abnormal_feces_composition0.75166941
128MP0002398_abnormal_bone_marrow0.74130817
129MP0009115_abnormal_fat_cell0.73798049
130MP0000685_abnormal_immune_system0.73377947
131MP0000538_abnormal_urinary_bladder0.72427147
132MP0002113_abnormal_skeleton_development0.71269251
133MP0002092_abnormal_eye_morphology0.71250059
134MP0005174_abnormal_tail_pigmentation0.70858491
135MP0003448_altered_tumor_morphology0.70580665
136MP0000647_abnormal_sebaceous_gland0.70469717
137MP0002109_abnormal_limb_morphology0.70078888
138MP0001119_abnormal_female_reproductive0.70063005
139MP0002085_abnormal_embryonic_tissue0.70024066
140MP0000383_abnormal_hair_follicle0.69903579
141MP0002998_abnormal_bone_remodeling0.69136630
142MP0010630_abnormal_cardiac_muscle0.69061901
143MP0005365_abnormal_bile_salt0.69060167
144MP0000490_abnormal_crypts_of0.69028866
145MP0003828_pulmonary_edema0.68908151
146MP0000627_abnormal_mammary_gland0.68718645
147MP0001324_abnormal_eye_pigmentation0.68520988
148MP0005623_abnormal_meninges_morphology0.68500863
149MP0002128_abnormal_blood_circulation0.68419718
150MP0000428_abnormal_craniofacial_morphol0.68169715
151MP0001944_abnormal_pancreas_morphology0.65041362
152MP0003936_abnormal_reproductive_system0.64782721
153MP0002693_abnormal_pancreas_physiology0.64508214
154MP0001191_abnormal_skin_condition0.63233277
155MP0004043_abnormal_pH_regulation0.61921487
156MP0001800_abnormal_humoral_immune0.61022892
157MP0005395_other_phenotype0.60873966
158MP0010329_abnormal_lipoprotein_level0.59421270
159MP0001919_abnormal_reproductive_system0.58529513
160MP0005266_abnormal_metabolism0.58455762
161MP0004233_abnormal_muscle_weight0.57097125

Predicted human phenotypes

RankGene SetZ-score
1Dysmetric saccades (HP:0000641)4.87177046
2Genetic anticipation (HP:0003743)4.26691511
3Gaze-evoked nystagmus (HP:0000640)3.86089204
4Fair hair (HP:0002286)3.48293327
5Volvulus (HP:0002580)3.37240645
6Generalized hypopigmentation of hair (HP:0011358)3.28328114
7Abnormality of the fingertips (HP:0001211)3.26365171
8Absent frontal sinuses (HP:0002688)3.22999180
9Thyroiditis (HP:0100646)3.19234166
10Abnormality of the renal cortex (HP:0011035)3.08919654
11Lip pit (HP:0100267)3.01144165
12Acute lymphatic leukemia (HP:0006721)2.94531293
13Asymmetry of the thorax (HP:0001555)2.93598025
14Chromsome breakage (HP:0040012)2.89132116
15Neonatal short-limb short stature (HP:0008921)2.85653005
16Syringomyelia (HP:0003396)2.75442862
17Spinal cord lesions (HP:0100561)2.75442862
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.72553441
19Short 4th metacarpal (HP:0010044)2.72553441
20Progressive cerebellar ataxia (HP:0002073)2.64977268
21Deep philtrum (HP:0002002)2.61611495
22Clubbing of toes (HP:0100760)2.59732527
23Short chin (HP:0000331)2.57428654
24Ectopic kidney (HP:0000086)2.50974599
25Constricted visual fields (HP:0001133)2.48934167
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.48166828
27Muscle hypertrophy of the lower extremities (HP:0008968)2.46350695
28Curly hair (HP:0002212)2.45842096
29Protruding tongue (HP:0010808)2.44170234
30Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.43325639
31Hyperventilation (HP:0002883)2.42714382
32Neonatal hypoglycemia (HP:0001998)2.41874113
33Abnormality of chromosome stability (HP:0003220)2.41705021
34Sandal gap (HP:0001852)2.37343076
35Ankle contracture (HP:0006466)2.37314800
36Aortic aneurysm (HP:0004942)2.36940014
37T lymphocytopenia (HP:0005403)2.36039986
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34947392
39Sparse lateral eyebrow (HP:0005338)2.32758210
40Truncal obesity (HP:0001956)2.31026594
41Abnormality of the preputium (HP:0100587)2.29729206
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.28682150
43Osteolytic defects of the hand bones (HP:0009699)2.28682150
44Protrusio acetabuli (HP:0003179)2.28491471
45Blue irides (HP:0000635)2.26706444
46Cervical subluxation (HP:0003308)2.26604187
47Hematochezia (HP:0002573)2.24813533
48Abnormality of the nasal septum (HP:0000419)2.24126829
49Abnormality of the frontal sinuses (HP:0002687)2.21266966
50Hypochromic microcytic anemia (HP:0004840)2.20735713
51Thyroid carcinoma (HP:0002890)2.19898198
52Macroorchidism (HP:0000053)2.19325045
53Hamartoma of the eye (HP:0010568)2.18657400
54Long eyelashes (HP:0000527)2.17281337
55Enlarged penis (HP:0000040)2.17187749
56Chronic hepatic failure (HP:0100626)2.17014402
57Abnormality of T cell number (HP:0011839)2.16055080
58Acute myeloid leukemia (HP:0004808)2.15493619
59Pancreatic cysts (HP:0001737)2.14247826
60Metaphyseal cupping (HP:0003021)2.13035089
61Mild short stature (HP:0003502)2.12925927
62Long foot (HP:0001833)2.11293205
63Rhabdomyosarcoma (HP:0002859)2.11263715
64Meningioma (HP:0002858)2.08642363
65Subacute progressive viral hepatitis (HP:0006572)2.07542903
66Urinary bladder sphincter dysfunction (HP:0002839)2.07300760
67Widely spaced teeth (HP:0000687)2.07236457
68Mesomelia (HP:0003027)2.06185402
69Portal hypertension (HP:0001409)2.04690544
70Abnormal foot bone ossification (HP:0010675)2.04562195
71Pheochromocytoma (HP:0002666)2.01791869
72High pitched voice (HP:0001620)2.01537485
73Abnormality of the 4th metacarpal (HP:0010012)2.00454157
74Attenuation of retinal blood vessels (HP:0007843)1.99682573
75Abnormality of the hepatic vasculature (HP:0006707)1.99174390
76Hypoplastic ischia (HP:0003175)1.98628771
77Persistence of primary teeth (HP:0006335)1.98076189
78Natal tooth (HP:0000695)1.97766988
79Proximal tubulopathy (HP:0000114)1.96275433
80Hypoplastic labia majora (HP:0000059)1.94180647
81Colon cancer (HP:0003003)1.92946369
82Metaphyseal dysplasia (HP:0100255)1.91116458
83Narrow palate (HP:0000189)1.89533878
84Neoplasm of the small intestine (HP:0100833)1.88979638
85Aqueductal stenosis (HP:0002410)1.88703798
86Abnormal biliary tract morphology (HP:0012440)1.88661388
87Breast carcinoma (HP:0003002)1.87127073
88Aortic dissection (HP:0002647)1.86217942
89Mitral valve prolapse (HP:0001634)1.85918367
90Amelogenesis imperfecta (HP:0000705)1.84735881
91Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.84281344
92Hypopigmentation of the fundus (HP:0007894)1.83513840
93Atrophic scars (HP:0001075)1.82120384
94Prominent nose (HP:0000448)1.81119966
95Elfin facies (HP:0004428)1.80859506
96Biliary tract neoplasm (HP:0100574)1.80572108
97Skull defect (HP:0001362)1.79679182
98Abnormality of the carotid arteries (HP:0005344)1.79517062
99Impaired smooth pursuit (HP:0007772)1.79117051
100Pancreatic islet-cell hyperplasia (HP:0004510)1.78588329
101Birth length less than 3rd percentile (HP:0003561)1.78586251
102Furrowed tongue (HP:0000221)1.78020631
103Abnormality of the labia majora (HP:0012881)1.77580263
104Impulsivity (HP:0100710)1.77531272
105Advanced eruption of teeth (HP:0006288)1.77518297
106Deviation of the thumb (HP:0009603)1.77364361
107Tubular atrophy (HP:0000092)1.77145456
108Hypoplastic iliac wings (HP:0002866)1.76911507
109Sloping forehead (HP:0000340)1.76865917
110Spondylolisthesis (HP:0003302)1.76374592
111Scanning speech (HP:0002168)1.74353314
112Nephroblastoma (Wilms tumor) (HP:0002667)1.74079298
113Glioma (HP:0009733)1.73570320
114Papillary thyroid carcinoma (HP:0002895)1.72964544
115Short 5th finger (HP:0009237)1.72962921
116Broad palm (HP:0001169)1.71425474
117Abnormality of the renal medulla (HP:0100957)1.70768556
118Chronic diarrhea (HP:0002028)1.70672937
119Abnormality of the incisor (HP:0000676)1.70124398
120Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.69288366
121Aplasia/Hypoplasia of the fovea (HP:0008060)1.69274143
122Hypoplasia of the fovea (HP:0007750)1.69274143
123Rectal prolapse (HP:0002035)1.68708941
124Premature rupture of membranes (HP:0001788)1.68647068
125Long nose (HP:0003189)1.68567850
126Short middle phalanx of the 5th finger (HP:0004220)1.68068078
127Shallow orbits (HP:0000586)1.67653563
128Aortic regurgitation (HP:0001659)1.66880499
129Increased nuchal translucency (HP:0010880)1.66650890
130Pancreatic fibrosis (HP:0100732)1.66559246
131Bowel diverticulosis (HP:0005222)1.64960630
132Cutaneous melanoma (HP:0012056)1.64059416
133Embryonal renal neoplasm (HP:0011794)1.63877716
134Abnormality of the ischium (HP:0003174)1.63064648
135Autoimmune hemolytic anemia (HP:0001890)1.61109672
136Arteriovenous malformation (HP:0100026)1.60216715
137Long clavicles (HP:0000890)1.60063723
138Cafe-au-lait spot (HP:0000957)1.59282980
139Urethral obstruction (HP:0000796)1.58968948
140Cutis marmorata (HP:0000965)1.58689929
141Tubulointerstitial nephritis (HP:0001970)1.58330999
142Abnormality of the ileum (HP:0001549)1.58326522
143Increased number of teeth (HP:0011069)1.57786731
144Cerebral aneurysm (HP:0004944)1.57731417
145Neoplasm of the adrenal cortex (HP:0100641)1.57407961
146Neoplasm of the oral cavity (HP:0100649)1.56910007
147Myelodysplasia (HP:0002863)1.56902174
148Duplicated collecting system (HP:0000081)1.56690614
149Obsessive-compulsive behavior (HP:0000722)1.56165122
150Limited elbow extension (HP:0001377)1.56059596
151Impaired vibratory sensation (HP:0002495)1.55410011
152IgA deficiency (HP:0002720)1.53942421
153Follicular hyperkeratosis (HP:0007502)1.52357737
154Periodontitis (HP:0000704)1.51873422
155Joint laxity (HP:0001388)1.51129022
156Proximal placement of thumb (HP:0009623)1.50990489
157Hypoplasia of the maxilla (HP:0000327)1.50771151
158Synostosis of carpal bones (HP:0005048)1.49548121
159Flared metaphyses (HP:0003015)1.49495435
160Abnormality of DNA repair (HP:0003254)1.48434345
161Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.48319464
162Stillbirth (HP:0003826)1.48311453
163Low anterior hairline (HP:0000294)1.47846121
164Dislocated radial head (HP:0003083)1.47404004
165Broad thumb (HP:0011304)1.46958437
166Increased mean platelet volume (HP:0011877)1.46382088
167Renal cortical cysts (HP:0000803)1.45809988
168Meckel diverticulum (HP:0002245)1.44971228
169Heterotopia (HP:0002282)1.44748184
170Dilatation of the ascending aorta (HP:0005111)1.44725654
171Neoplasm of the liver (HP:0002896)1.44076196
172Hypoglycemic coma (HP:0001325)1.43937725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.40817242
2INSRR3.34116991
3FLT32.25910109
4ZAK2.24389148
5CDC72.13329029
6CAMK1D2.07465339
7BMPR1B2.06992072
8LATS12.06687331
9EIF2AK31.96112465
10FRK1.94438147
11BRD41.88529334
12MAP3K141.84852661
13PDGFRA1.81344978
14ACVR1B1.78049134
15TIE11.73341599
16STK31.73213985
17CDK61.70167259
18NUAK11.68684219
19STK391.68581353
20FGFR31.66983966
21PKN21.64132715
22TTN1.62631991
23JAK31.62464825
24ATR1.52116907
25IRAK11.48213460
26CAMKK21.47965085
27OXSR11.47434483
28MELK1.46111888
29SGK21.39637451
30STK38L1.39030356
31NEK91.33810746
32SGK31.30516764
33JAK11.28638760
34NEK21.27474477
35STK101.26504279
36TYK21.24280147
37PTK61.20200914
38TTK1.19937387
39CDK41.19707849
40CAMK1G1.19480097
41TEC1.19291273
42RPS6KA41.17511993
43NEK61.17325101
44GRK11.16089631
45BMPR21.14182019
46STK41.13150523
47CHUK1.11426315
48SRPK11.10696456
49MKNK11.10481794
50SCYL21.10244620
51PDGFRB1.10039302
52ATM1.09249822
53PIK3CG1.08565705
54MKNK21.07810092
55WNK41.06892015
56TGFBR11.06711173
57CDK91.02801067
58AURKB1.02604006
59YES11.02380539
60KIT1.01886844
61PASK1.00486261
62FGFR40.99502162
63BRSK20.98223213
64ERBB30.97655776
65ADRBK20.94840740
66FGFR20.93790816
67MAP2K30.92642434
68NLK0.90985525
69RIPK10.90495336
70PIM10.90118318
71SIK10.88886380
72IRAK30.88683159
73MAP3K30.87920402
74TXK0.86372236
75MAP3K20.85774105
76TGFBR20.85592361
77CHEK10.85440691
78AKT30.85133087
79PIK3CA0.85057884
80WNK10.83616243
81MST40.78942743
82PLK30.77715241
83ITK0.77179128
84TRIB30.76953674
85DDR20.75556925
86MTOR0.75178320
87STK240.74915406
88CHEK20.73220412
89CDK70.72694225
90PLK10.71420485
91TLK10.71122981
92TAF10.70859627
93CSK0.70481886
94EPHA30.68567430
95EEF2K0.68215073
96RET0.66886550
97CDK20.61732639
98FGFR10.61443319
99IKBKB0.61027634
100EIF2AK20.60901982
101TAOK30.60712496
102TNIK0.60670380
103PAK20.60611886
104CSF1R0.60341131
105PLK40.59937124
106* TRPM70.59223429
107WNK30.57607400
108FER0.55468415
109CDK10.55084073
110BTK0.54668485
111MAP3K100.54185794
112MAP3K80.53774649
113MAPK110.53336854
114BMX0.52813370
115RPS6KB20.52574546
116MAPK140.52435704
117WEE10.51151357
118MAP3K70.49142213
119ILK0.48939972
120IRAK40.48127644
121RPS6KB10.47254380
122MAPK10.45945471
123MAP2K10.45758467
124PDK10.45578018
125CSNK1D0.45378251
126PRKAA20.45251845
127MARK30.44775712
128PRKDC0.43395522
129IKBKE0.43327275
130IGF1R0.43256846
131PNCK0.42625781
132PRKCE0.42293490
133ABL10.42290817
134RPS6KA60.39037783
135CDK30.38627414
136MAPKAPK30.37419956
137HIPK20.34226369
138LCK0.33916883
139MAP2K60.31322139
140MAP3K40.31204541

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.39601294
2Non-homologous end-joining_Homo sapiens_hsa034502.39073075
3One carbon pool by folate_Homo sapiens_hsa006702.25915436
4ABC transporters_Homo sapiens_hsa020102.23750210
5DNA replication_Homo sapiens_hsa030302.08210784
6Cell cycle_Homo sapiens_hsa041102.04972783
7Mismatch repair_Homo sapiens_hsa034302.04623819
8Small cell lung cancer_Homo sapiens_hsa052221.85179359
9ECM-receptor interaction_Homo sapiens_hsa045121.78083187
10Adherens junction_Homo sapiens_hsa045201.74251339
11MicroRNAs in cancer_Homo sapiens_hsa052061.69038756
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.65659424
13Fanconi anemia pathway_Homo sapiens_hsa034601.65294627
14Herpes simplex infection_Homo sapiens_hsa051681.60061588
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.52678661
16Base excision repair_Homo sapiens_hsa034101.48614178
17Butanoate metabolism_Homo sapiens_hsa006501.42744089
18Dorso-ventral axis formation_Homo sapiens_hsa043201.36258139
19Chronic myeloid leukemia_Homo sapiens_hsa052201.34352309
20p53 signaling pathway_Homo sapiens_hsa041151.33994525
21Focal adhesion_Homo sapiens_hsa045101.32852787
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28309996
23Prostate cancer_Homo sapiens_hsa052151.25190850
24Homologous recombination_Homo sapiens_hsa034401.24789750
25Measles_Homo sapiens_hsa051621.24611303
26TGF-beta signaling pathway_Homo sapiens_hsa043501.24320750
27Nitrogen metabolism_Homo sapiens_hsa009101.23886564
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.23277546
29Caffeine metabolism_Homo sapiens_hsa002321.23155020
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20975570
31HTLV-I infection_Homo sapiens_hsa051661.19114933
32Type I diabetes mellitus_Homo sapiens_hsa049401.16986971
33Hepatitis B_Homo sapiens_hsa051611.14921994
34Linoleic acid metabolism_Homo sapiens_hsa005911.14775688
35Toxoplasmosis_Homo sapiens_hsa051451.12972618
36Pancreatic cancer_Homo sapiens_hsa052121.11291421
37Viral carcinogenesis_Homo sapiens_hsa052031.10934861
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.10022124
39Nucleotide excision repair_Homo sapiens_hsa034201.09839797
40Proteoglycans in cancer_Homo sapiens_hsa052051.08674099
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07117854
42RNA degradation_Homo sapiens_hsa030181.07002141
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06164685
44Basal transcription factors_Homo sapiens_hsa030221.04973588
45Allograft rejection_Homo sapiens_hsa053301.04941424
46FoxO signaling pathway_Homo sapiens_hsa040681.02114568
47RNA transport_Homo sapiens_hsa030131.01620718
48Ether lipid metabolism_Homo sapiens_hsa005650.99181599
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98672516
50Leishmaniasis_Homo sapiens_hsa051400.96931122
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95638656
52Influenza A_Homo sapiens_hsa051640.93896829
53Legionellosis_Homo sapiens_hsa051340.93192918
54TNF signaling pathway_Homo sapiens_hsa046680.92008669
55Antigen processing and presentation_Homo sapiens_hsa046120.91536703
56Sphingolipid metabolism_Homo sapiens_hsa006000.90402489
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89903373
58Circadian rhythm_Homo sapiens_hsa047100.89842564
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89525788
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88351998
61Protein digestion and absorption_Homo sapiens_hsa049740.88126416
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87658723
63Viral myocarditis_Homo sapiens_hsa054160.87295646
64mRNA surveillance pathway_Homo sapiens_hsa030150.86146703
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86060828
66Insulin resistance_Homo sapiens_hsa049310.84346312
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83941020
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83763239
69Apoptosis_Homo sapiens_hsa042100.83571140
70Autoimmune thyroid disease_Homo sapiens_hsa053200.81371260
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79758335
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79000454
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.78194754
74Systemic lupus erythematosus_Homo sapiens_hsa053220.78043994
75Osteoclast differentiation_Homo sapiens_hsa043800.77701462
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76834812
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76265827
78Asthma_Homo sapiens_hsa053100.75799419
79Renal cell carcinoma_Homo sapiens_hsa052110.75517135
80Ovarian steroidogenesis_Homo sapiens_hsa049130.75381850
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75213944
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74880640
83Selenocompound metabolism_Homo sapiens_hsa004500.74632952
84Choline metabolism in cancer_Homo sapiens_hsa052310.73820203
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.71143561
86Renin-angiotensin system_Homo sapiens_hsa046140.71079084
87Notch signaling pathway_Homo sapiens_hsa043300.70266070
88Hepatitis C_Homo sapiens_hsa051600.68925528
89Hematopoietic cell lineage_Homo sapiens_hsa046400.68447821
90Pathways in cancer_Homo sapiens_hsa052000.68354931
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67910696
92Tryptophan metabolism_Homo sapiens_hsa003800.67671548
93Glioma_Homo sapiens_hsa052140.67042450
94B cell receptor signaling pathway_Homo sapiens_hsa046620.67019013
95Colorectal cancer_Homo sapiens_hsa052100.65796843
96Malaria_Homo sapiens_hsa051440.65721006
97Propanoate metabolism_Homo sapiens_hsa006400.65390368
98Type II diabetes mellitus_Homo sapiens_hsa049300.64335435
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63711241
100Fatty acid degradation_Homo sapiens_hsa000710.63066514
101HIF-1 signaling pathway_Homo sapiens_hsa040660.62118404
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.61833345
103ErbB signaling pathway_Homo sapiens_hsa040120.61716654
104Platelet activation_Homo sapiens_hsa046110.61360056
105PPAR signaling pathway_Homo sapiens_hsa033200.60982443
106Basal cell carcinoma_Homo sapiens_hsa052170.60978574
107Primary immunodeficiency_Homo sapiens_hsa053400.60959656
108Non-small cell lung cancer_Homo sapiens_hsa052230.60863208
109Spliceosome_Homo sapiens_hsa030400.60536676
110African trypanosomiasis_Homo sapiens_hsa051430.59251572
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59209826
112mTOR signaling pathway_Homo sapiens_hsa041500.58939362
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58900820
114Endometrial cancer_Homo sapiens_hsa052130.58460583
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57356445
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56789065
117Epstein-Barr virus infection_Homo sapiens_hsa051690.56015828
118Prolactin signaling pathway_Homo sapiens_hsa049170.54265535
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.52991988
120Thyroid cancer_Homo sapiens_hsa052160.52670310
121Melanoma_Homo sapiens_hsa052180.52650665
122Acute myeloid leukemia_Homo sapiens_hsa052210.50981270
123Vitamin digestion and absorption_Homo sapiens_hsa049770.50977221
124Amoebiasis_Homo sapiens_hsa051460.50704441
125Glucagon signaling pathway_Homo sapiens_hsa049220.50547224
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50439525
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49655382
128Retinol metabolism_Homo sapiens_hsa008300.49346956
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.49211250
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49016426
131Inositol phosphate metabolism_Homo sapiens_hsa005620.48970137
132Phototransduction_Homo sapiens_hsa047440.48931416
133Insulin signaling pathway_Homo sapiens_hsa049100.47865576
134Hippo signaling pathway_Homo sapiens_hsa043900.47529372
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47410841
136T cell receptor signaling pathway_Homo sapiens_hsa046600.47403896
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45766876
138Other glycan degradation_Homo sapiens_hsa005110.45244408
139N-Glycan biosynthesis_Homo sapiens_hsa005100.44590946

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