TRPM8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)8.67408757
2iron ion import (GO:0097286)7.21995747
3branching involved in prostate gland morphogenesis (GO:0060442)6.40162520
4biotin metabolic process (GO:0006768)6.34030543
5sperm motility (GO:0030317)6.06854132
6neurofilament cytoskeleton organization (GO:0060052)5.90621909
7detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.63799294
8detection of temperature stimulus involved in sensory perception (GO:0050961)5.63799294
9negative regulation of multicellular organism growth (GO:0040015)5.59315288
10adaptation of signaling pathway (GO:0023058)5.54874279
11* detection of temperature stimulus (GO:0016048)5.35649941
12protein autoprocessing (GO:0016540)5.30909430
13calcium ion-dependent exocytosis (GO:0017156)5.28305681
14adenosine metabolic process (GO:0046085)5.23859584
15cell wall macromolecule metabolic process (GO:0044036)5.23823795
16cell wall macromolecule catabolic process (GO:0016998)5.23823795
17negative regulation of amyloid precursor protein catabolic process (GO:1902992)5.21847213
18import into cell (GO:0098657)5.14787429
19fusion of sperm to egg plasma membrane (GO:0007342)5.14522979
20artery development (GO:0060840)5.07813505
21regulation of memory T cell differentiation (GO:0043380)4.98170162
22synaptic vesicle maturation (GO:0016188)4.91383728
23sperm capacitation (GO:0048240)4.68563778
24proline transport (GO:0015824)4.67877904
25axon cargo transport (GO:0008088)4.52803171
26acrosome assembly (GO:0001675)4.52169457
27negative regulation of microtubule polymerization (GO:0031115)4.51191211
28opsonization (GO:0008228)4.47492049
29prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.46228636
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.45532264
31indole-containing compound catabolic process (GO:0042436)4.44232382
32indolalkylamine catabolic process (GO:0046218)4.44232382
33tryptophan catabolic process (GO:0006569)4.44232382
34positive regulation of steroid hormone secretion (GO:2000833)4.43280827
35sperm-egg recognition (GO:0035036)4.42725676
36negative regulation of inclusion body assembly (GO:0090084)4.32619258
37negative regulation of organelle assembly (GO:1902116)4.30782851
38multicellular organism reproduction (GO:0032504)4.26389160
39bile acid biosynthetic process (GO:0006699)4.26264354
40retinal metabolic process (GO:0042574)4.22875697
41cell migration in hindbrain (GO:0021535)4.18328449
42kynurenine metabolic process (GO:0070189)4.15617675
43sex differentiation (GO:0007548)4.14995159
44membrane depolarization during action potential (GO:0086010)4.14892983
45acetyl-CoA metabolic process (GO:0006084)4.13108368
46negative regulation of heart rate (GO:0010459)4.12036913
47sensory perception of pain (GO:0019233)4.07385299
48prostate gland epithelium morphogenesis (GO:0060740)4.06617484
49mitotic cell cycle arrest (GO:0071850)4.05417350
50reproduction (GO:0000003)4.04123784
51plasma membrane fusion (GO:0045026)4.02686032
52positive regulation of fatty acid beta-oxidation (GO:0032000)4.02534239
53regulation of establishment of cell polarity (GO:2000114)4.01434860
54cytoplasmic mRNA processing body assembly (GO:0033962)4.00688888
55respiratory electron transport chain (GO:0022904)3.97508419
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.97057091
57regulation of establishment or maintenance of cell polarity (GO:0032878)3.94284764
58epithelial cell maturation (GO:0002070)3.92492851
59electron transport chain (GO:0022900)3.90765887
60neuronal action potential propagation (GO:0019227)3.90541207
61binding of sperm to zona pellucida (GO:0007339)3.88266344
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.86995287
63epithelial cilium movement (GO:0003351)3.84468477
64cell-cell recognition (GO:0009988)3.84409125
65neuronal action potential (GO:0019228)3.83735475
66tryptophan metabolic process (GO:0006568)3.80182514
67fatty acid transmembrane transport (GO:1902001)3.70888911
68response to acidic pH (GO:0010447)3.69223989
69pharyngeal system development (GO:0060037)3.68597613
70spermatid development (GO:0007286)3.58445250
71regulation of receptor binding (GO:1900120)3.56476810
72regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.56333094
73cellular ketone body metabolic process (GO:0046950)3.56077333
74regulation of short-term neuronal synaptic plasticity (GO:0048172)3.54842721
75hydrogen ion transmembrane transport (GO:1902600)3.50199683
76regulation of amyloid precursor protein catabolic process (GO:1902991)3.48426197
77eating behavior (GO:0042755)3.46378027
78aromatic amino acid family catabolic process (GO:0009074)3.45942458
79regulation of fatty acid beta-oxidation (GO:0031998)3.45145206
80chaperone-mediated protein transport (GO:0072321)3.44082535
81carnitine shuttle (GO:0006853)3.43386927
82mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.42462941
83negative regulation of sodium ion transport (GO:0010766)3.41243130
84positive regulation of fatty acid oxidation (GO:0046321)3.40549064
85sodium ion export (GO:0071436)3.38675961
86negative regulation of dendrite morphogenesis (GO:0050774)3.38520172
87intermediate filament organization (GO:0045109)3.36638592
88indolalkylamine metabolic process (GO:0006586)3.36232840
89piRNA metabolic process (GO:0034587)3.34641641
90positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.34160480
91omega-hydroxylase P450 pathway (GO:0097267)3.31061705
92cellular potassium ion homeostasis (GO:0030007)3.30829383
93negative regulation of systemic arterial blood pressure (GO:0003085)3.30147265
94behavioral response to nicotine (GO:0035095)3.29597225
95regulation of inclusion body assembly (GO:0090083)3.27632498
96positive regulation of potassium ion transmembrane transport (GO:1901381)3.27081184
97sexual reproduction (GO:0019953)3.26194970
98regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.23846669
99regulation of action potential (GO:0098900)3.20030226
100chemosensory behavior (GO:0007635)3.19735352
101endothelial cell chemotaxis (GO:0035767)3.19570893
102detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.19266619
103ketone body metabolic process (GO:1902224)3.18501676
104positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.17500786
105lung lobe morphogenesis (GO:0060463)3.17095307
106microtubule depolymerization (GO:0007019)3.16563198
107protein maturation by protein folding (GO:0022417)3.16502101
108calcium-mediated signaling using intracellular calcium source (GO:0035584)3.15981533
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.14058605
110glutamate secretion (GO:0014047)3.12991135
111cellular biogenic amine catabolic process (GO:0042402)3.11478225
112amine catabolic process (GO:0009310)3.11478225
113sterol catabolic process (GO:0016127)3.06844242
114cholesterol catabolic process (GO:0006707)3.06844242
115epoxygenase P450 pathway (GO:0019373)3.04673026
116long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.03659459
117cilium movement (GO:0003341)3.02688398
118lung epithelial cell differentiation (GO:0060487)3.02417766
119regulation of microtubule-based movement (GO:0060632)3.02260115
120male meiosis (GO:0007140)3.01615818
121regulation of MHC class I biosynthetic process (GO:0045343)3.00861068
122positive regulation of glycolytic process (GO:0045821)3.00244016
123neuron cell-cell adhesion (GO:0007158)3.00152356
124neuromuscular process controlling balance (GO:0050885)3.00052267
125acid secretion (GO:0046717)2.99039797
126regulation of steroid hormone secretion (GO:2000831)2.98094471
127ATP biosynthetic process (GO:0006754)2.98029654
128intermediate filament-based process (GO:0045103)2.98009850
129cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.97814243
130retinal ganglion cell axon guidance (GO:0031290)2.97552048
131purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.97489852
132drug catabolic process (GO:0042737)2.97205639
133energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95805440
134ATP synthesis coupled proton transport (GO:0015986)2.95805440
135positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.95745876
136GTP biosynthetic process (GO:0006183)2.95600544
137DNA methylation involved in gamete generation (GO:0043046)2.95589480
138cell communication involved in cardiac conduction (GO:0086065)2.95535491
139behavioral response to pain (GO:0048266)2.94833519
140axonemal dynein complex assembly (GO:0070286)2.93075486
141purine nucleoside triphosphate biosynthetic process (GO:0009145)2.92910510
142intermediate filament cytoskeleton organization (GO:0045104)2.92773748
143synaptonemal complex assembly (GO:0007130)2.92443257
144synaptonemal complex organization (GO:0070193)2.92276721
145intestinal epithelial cell development (GO:0060576)2.88557459
146bile acid metabolic process (GO:0008206)2.88234696
147regulation of lipoprotein metabolic process (GO:0050746)2.87563287
148fatty-acyl-CoA biosynthetic process (GO:0046949)2.87316238
149response to pain (GO:0048265)2.86876388
150synaptic vesicle docking involved in exocytosis (GO:0016081)2.86461263
151benzene-containing compound metabolic process (GO:0042537)2.86274937
152branched-chain amino acid catabolic process (GO:0009083)2.85242960
153lung cell differentiation (GO:0060479)2.84487947
154axon development (GO:0061564)2.84358254
155oxidative demethylation (GO:0070989)2.84303706
156carnitine transmembrane transport (GO:1902603)2.82713550
157retinol metabolic process (GO:0042572)2.82159569
158proton transport (GO:0015992)2.81929162
159regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.81231512
160positive regulation of action potential (GO:0045760)2.81187376
161cytoskeleton-dependent intracellular transport (GO:0030705)2.79807837
162regulation of sensory perception of pain (GO:0051930)2.79372859
163regulation of sensory perception (GO:0051931)2.79372859
164establishment of mitochondrion localization (GO:0051654)2.78578024
165regulation of triglyceride catabolic process (GO:0010896)2.78512987
166establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.78423763
167mitochondrion transport along microtubule (GO:0047497)2.78423763
168microtubule polymerization or depolymerization (GO:0031109)2.77608040
169coenzyme catabolic process (GO:0009109)2.77159007
170copper ion transport (GO:0006825)2.77076910
171hydrogen transport (GO:0006818)2.76871441
172exogenous drug catabolic process (GO:0042738)2.76634040
173CDP-diacylglycerol biosynthetic process (GO:0016024)2.76248609
174membrane repolarization (GO:0086009)2.76016038
175membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.75639457
176histone H3-K4 trimethylation (GO:0080182)2.75550541
177UDP-N-acetylglucosamine metabolic process (GO:0006047)2.74704890
178microtubule-based transport (GO:0010970)2.73905335
179enteric nervous system development (GO:0048484)2.72911433
180methionine metabolic process (GO:0006555)2.71962298
181response to water (GO:0009415)2.71661069
182retina homeostasis (GO:0001895)2.69692008
183lung secretory cell differentiation (GO:0061140)2.68392355
184pantothenate metabolic process (GO:0015939)2.68055768
185carnitine transport (GO:0015879)2.67644634
186amino-acid betaine transport (GO:0015838)2.67644634
187reflex (GO:0060004)2.64568615
188L-methionine salvage (GO:0071267)2.63689926
189L-methionine biosynthetic process (GO:0071265)2.63689926
190amino acid salvage (GO:0043102)2.63689926
191regulation of fatty acid oxidation (GO:0046320)2.62818085
192lipid translocation (GO:0034204)2.62519796
193phospholipid translocation (GO:0045332)2.62519796
194L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61281845
195ADP metabolic process (GO:0046031)2.60672965
196glyoxylate metabolic process (GO:0046487)2.58506035
197thioester biosynthetic process (GO:0035384)2.56788155
198acyl-CoA biosynthetic process (GO:0071616)2.56788155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.16465775
2IGF1R_20145208_ChIP-Seq_DFB_Human3.29490187
3* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human3.12645058
4AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.86392319
5REST_21632747_ChIP-Seq_MESCs_Mouse2.67810395
6TAF15_26573619_Chip-Seq_HEK293_Human2.40338397
7SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35072716
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35047513
9* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29505750
10EZH2_27294783_Chip-Seq_ESCs_Mouse2.27771009
11AR_21572438_ChIP-Seq_LNCaP_Human2.25655730
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23493912
13* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.17303747
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15338332
15FOXA1_25552417_ChIP-Seq_VCAP_Human2.10505998
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10260474
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08018937
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07043307
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97375340
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95395480
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95395480
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93038016
23ER_23166858_ChIP-Seq_MCF-7_Human1.89695896
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.88221118
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87278259
26ZNF274_21170338_ChIP-Seq_K562_Hela1.87217156
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85424921
28AR_21909140_ChIP-Seq_LNCAP_Human1.85269408
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.77518811
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77221549
31DROSHA_22980978_ChIP-Seq_HELA_Human1.71666291
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70854104
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.68917603
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66169774
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64898038
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62829433
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61444588
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.60587222
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60029225
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56210134
41FOXM1_26456572_ChIP-Seq_MCF-7_Human1.54902303
42BCAT_22108803_ChIP-Seq_LS180_Human1.53194742
43TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52535522
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.50880736
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50744122
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50723825
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50707099
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50590623
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.49380727
50* OCT1_27270436_Chip-Seq_PROSTATE_Human1.48869331
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.48384653
52MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47936305
53ZNF263_19887448_ChIP-Seq_K562_Human1.47682646
54KDM2B_26808549_Chip-Seq_REH_Human1.47380140
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43230021
56CTCF_27219007_Chip-Seq_Bcells_Human1.40442267
57STAT3_23295773_ChIP-Seq_U87_Human1.39993238
58RUNX2_22187159_ChIP-Seq_PCA_Human1.39509595
59* TCF4_23295773_ChIP-Seq_U87_Human1.38544098
60AR_20517297_ChIP-Seq_VCAP_Human1.38000195
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36756399
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36756399
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36459016
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36157146
65IRF1_19129219_ChIP-ChIP_H3396_Human1.33429984
66ELK4_26923725_Chip-Seq_MESODERM_Mouse1.32147708
67SMAD4_21799915_ChIP-Seq_A2780_Human1.32134221
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.24952185
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24022725
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23924693
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.20410083
72EGR1_19032775_ChIP-ChIP_M12_Human1.19899837
73AHR_22903824_ChIP-Seq_MCF-7_Human1.19081898
74* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18925226
75RNF2_27304074_Chip-Seq_NSC_Mouse1.18686275
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16474067
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16306321
78* FLI1_27457419_Chip-Seq_LIVER_Mouse1.16132534
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15942799
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15783002
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.15605672
82HTT_18923047_ChIP-ChIP_STHdh_Human1.15154000
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.14817768
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14757668
85TP53_22573176_ChIP-Seq_HFKS_Human1.14532298
86SMAD3_21741376_ChIP-Seq_ESCs_Human1.14012052
87VDR_22108803_ChIP-Seq_LS180_Human1.13932224
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13161250
89ERG_20517297_ChIP-Seq_VCAP_Human1.13145651
90* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.12838171
91P300_19829295_ChIP-Seq_ESCs_Human1.12125643
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.11864464
93GBX2_23144817_ChIP-Seq_PC3_Human1.10500453
94* PRDM14_20953172_ChIP-Seq_ESCs_Human1.09711812
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09603564
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.09412979
97* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07133426
98EWS_26573619_Chip-Seq_HEK293_Human1.06886733
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06727194
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06593303
101CBP_20019798_ChIP-Seq_JUKART_Human1.06593303
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06532255
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06211544
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05995563
105RXR_22108803_ChIP-Seq_LS180_Human1.05728956
106ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05372284
107* YY1_22570637_ChIP-Seq_MALME-3M_Human1.04634157
108OCT4_20526341_ChIP-Seq_ESCs_Human1.03806145
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03694301
110SA1_27219007_Chip-Seq_Bcells_Human1.03193504
111* CDX2_22108803_ChIP-Seq_LS180_Human1.02761167
112EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02495718
113* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01617899
114* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01605259
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01294894
116GF1_26923725_Chip-Seq_HPCs_Mouse1.00803745
117* TCF4_22108803_ChIP-Seq_LS180_Human0.99591308
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99261109
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99251647
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98983130
121GATA4_25053715_ChIP-Seq_YYC3_Human0.98520751
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97737584
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97669585
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97135839
125FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96891138
126FOXA1_25329375_ChIP-Seq_VCAP_Human0.96891138
127FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96563739
128CBX2_27304074_Chip-Seq_ESCs_Mouse0.96348642
129SALL1_21062744_ChIP-ChIP_HESCs_Human0.95813431
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95422337
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.95408832
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95216682
133CTCF_20526341_ChIP-Seq_ESCs_Human0.94857048
134EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94711353
135RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94215873
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93815293
137* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93690205
138ERA_21632823_ChIP-Seq_H3396_Human0.93464413
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93457789
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92980190
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92552687
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.92523447
143AR_25329375_ChIP-Seq_VCAP_Human0.92014165
144* NFE2_27457419_Chip-Seq_LIVER_Mouse0.91561723
145* EZH2_27294783_Chip-Seq_NPCs_Mouse0.91333210
146ESR1_21235772_ChIP-Seq_MCF-7_Human0.91145434
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90987186
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.90435387
149SOX2_21211035_ChIP-Seq_LN229_Gbm0.90321161
150STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90039517
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89936356
152* PIAS1_25552417_ChIP-Seq_VCAP_Human0.89809590
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89387350
154SA1_27219007_Chip-Seq_ERYTHROID_Human0.88232731
155SOX2_19829295_ChIP-Seq_ESCs_Human0.87296959
156NANOG_19829295_ChIP-Seq_ESCs_Human0.87296959
157RING1B_27294783_Chip-Seq_ESCs_Mouse0.86775874
158PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86597752
159ARNT_22903824_ChIP-Seq_MCF-7_Human0.86111925
160* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85825212
161BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84485646
162SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83669716
163SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83496977
164PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82234009
165SMAD4_21741376_ChIP-Seq_EPCs_Human0.82091761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.68625936
2MP0003011_delayed_dark_adaptation5.59514032
3MP0002735_abnormal_chemical_nociception5.51345254
4* MP0001968_abnormal_touch/_nociception4.68626586
5MP0004270_analgesia4.43678595
6* MP0002733_abnormal_thermal_nociception4.10059975
7MP0005167_abnormal_blood-brain_barrier4.06069416
8MP0004859_abnormal_synaptic_plasticity3.71135585
9MP0006276_abnormal_autonomic_nervous3.69886568
10* MP0002736_abnormal_nociception_after3.68991752
11MP0004043_abnormal_pH_regulation3.57890163
12MP0004858_abnormal_nervous_system3.52114977
13MP0002234_abnormal_pharynx_morphology3.44695403
14MP0005310_abnormal_salivary_gland3.35501529
15MP0005360_urolithiasis3.30483306
16MP0002734_abnormal_mechanical_nocicepti3.25510819
17* MP0001970_abnormal_pain_threshold3.15772975
18MP0005645_abnormal_hypothalamus_physiol3.10760587
19MP0001986_abnormal_taste_sensitivity2.99570498
20MP0003252_abnormal_bile_duct2.87956711
21MP0005646_abnormal_pituitary_gland2.65812551
22MP0003880_abnormal_central_pattern2.57103731
23MP0002166_altered_tumor_susceptibility2.50736758
24MP0005647_abnormal_sex_gland2.38167639
25MP0002138_abnormal_hepatobiliary_system2.24368555
26MP0001440_abnormal_grooming_behavior2.24142684
27MP0002272_abnormal_nervous_system2.10658985
28MP0003195_calcinosis2.09073449
29MP0009379_abnormal_foot_pigmentation2.08524989
30MP0008961_abnormal_basal_metabolism2.08500895
31MP0005551_abnormal_eye_electrophysiolog2.07617742
32MP0001502_abnormal_circadian_rhythm2.01251721
33MP0003635_abnormal_synaptic_transmissio2.00025605
34MP0003698_abnormal_male_reproductive1.94801505
35MP0000751_myopathy1.91636299
36MP0002184_abnormal_innervation1.88672872
37MP0009745_abnormal_behavioral_response1.78453538
38MP0002006_tumorigenesis1.76560966
39* MP0004811_abnormal_neuron_physiology1.70472382
40* MP0002067_abnormal_sensory_capabilities1.66745541
41MP0005670_abnormal_white_adipose1.61193342
42MP0001664_abnormal_digestion1.60625873
43MP0009046_muscle_twitch1.60220410
44MP0005423_abnormal_somatic_nervous1.60040787
45MP0002064_seizures1.58902599
46MP0002063_abnormal_learning/memory/cond1.57438402
47MP0001873_stomach_inflammation1.57088914
48MP0002572_abnormal_emotion/affect_behav1.55146408
49MP0000613_abnormal_salivary_gland1.52123334
50MP0004742_abnormal_vestibular_system1.50676477
51MP0003315_abnormal_perineum_morphology1.50238168
52MP0001929_abnormal_gametogenesis1.49115875
53MP0000538_abnormal_urinary_bladder1.45503476
54MP0000230_abnormal_systemic_arterial1.45074394
55MP0003646_muscle_fatigue1.44726729
56MP0003633_abnormal_nervous_system1.39754026
57MP0010386_abnormal_urinary_bladder1.38022827
58MP0001756_abnormal_urination1.33529888
59MP0003879_abnormal_hair_cell1.29286625
60MP0008875_abnormal_xenobiotic_pharmacok1.29203554
61MP0001486_abnormal_startle_reflex1.28069454
62MP0000631_abnormal_neuroendocrine_gland1.27087203
63MP0000955_abnormal_spinal_cord1.24958821
64MP0005187_abnormal_penis_morphology1.23054509
65MP0005623_abnormal_meninges_morphology1.22892725
66MP0004145_abnormal_muscle_electrophysio1.22062287
67MP0002822_catalepsy1.21734973
68MP0001765_abnormal_ion_homeostasis1.21121274
69MP0002229_neurodegeneration1.18484600
70MP0005365_abnormal_bile_salt1.18345143
71MP0001666_abnormal_nutrient_absorption1.18071096
72MP0008874_decreased_physiological_sensi1.17698481
73MP0005220_abnormal_exocrine_pancreas1.15562092
74MP0003828_pulmonary_edema1.14893461
75MP0008877_abnormal_DNA_methylation1.14401566
76MP0005636_abnormal_mineral_homeostasis1.14330404
77MP0002882_abnormal_neuron_morphology1.13755517
78MP0002693_abnormal_pancreas_physiology1.13398652
79MP0000537_abnormal_urethra_morphology1.13330420
80MP0003631_nervous_system_phenotype1.12544144
81MP0001764_abnormal_homeostasis1.11394347
82MP0000920_abnormal_myelination1.09608923
83MP0002066_abnormal_motor_capabilities/c1.09553890
84MP0000371_diluted_coat_color1.09530590
85MP0005367_renal/urinary_system_phenotyp1.08961344
86MP0000516_abnormal_urinary_system1.08961344
87MP0002160_abnormal_reproductive_system1.08915672
88MP0008569_lethality_at_weaning1.08335476
89MP0003329_amyloid_beta_deposits1.08155413
90MP0002557_abnormal_social/conspecific_i1.07428313
91MP0004885_abnormal_endolymph1.07364998
92MP0002638_abnormal_pupillary_reflex1.07342239
93MP0002118_abnormal_lipid_homeostasis1.06171311
94MP0002751_abnormal_autonomic_nervous1.04179551
95MP0010329_abnormal_lipoprotein_level1.04045765
96MP0002161_abnormal_fertility/fecundity1.03017391
97MP0000778_abnormal_nervous_system1.02231122
98MP0000569_abnormal_digit_pigmentation1.01304978
99MP0003890_abnormal_embryonic-extraembry0.99393876
100MP0004036_abnormal_muscle_relaxation0.98803700
101MP0002090_abnormal_vision0.97730650
102MP0005448_abnormal_energy_balance0.97039809
103MP0005083_abnormal_biliary_tract0.96523616
104MP0003634_abnormal_glial_cell0.96496561
105MP0003283_abnormal_digestive_organ0.95549676
106MP0003868_abnormal_feces_composition0.95122375
107MP0001529_abnormal_vocalization0.93807007
108MP0001944_abnormal_pancreas_morphology0.92349445
109MP0003953_abnormal_hormone_level0.91429833
110MP0000747_muscle_weakness0.91325511
111MP0002009_preneoplasia0.91171797
112MP0002752_abnormal_somatic_nervous0.90698402
113MP0003718_maternal_effect0.90514086
114MP0005535_abnormal_body_temperature0.89777767
115MP0001919_abnormal_reproductive_system0.89633967
116MP0001542_abnormal_bone_strength0.85127496
117MP0008872_abnormal_physiological_respon0.84820436
118MP0002078_abnormal_glucose_homeostasis0.84748274
119MP0006072_abnormal_retinal_apoptosis0.83490428
120MP0003045_fibrosis0.81637086
121MP0002102_abnormal_ear_morphology0.80621725
122MP0002653_abnormal_ependyma_morphology0.80445509
123MP0004924_abnormal_behavior0.79368085
124MP0005386_behavior/neurological_phenoty0.79368085
125MP0001963_abnormal_hearing_physiology0.77620703
126MP0001984_abnormal_olfaction0.76037450
127MP0005332_abnormal_amino_acid0.73165485
128MP0002909_abnormal_adrenal_gland0.72923161
129MP0002210_abnormal_sex_determination0.71778023
130MP0004883_abnormal_blood_vessel0.71120209
131MP0002277_abnormal_respiratory_mucosa0.66557080
132MP0000026_abnormal_inner_ear0.66408080
133MP0001348_abnormal_lacrimal_gland0.65615117
134MP0004019_abnormal_vitamin_homeostasis0.65548761
135MP0000534_abnormal_ureter_morphology0.65205797
136MP0002139_abnormal_hepatobiliary_system0.65195183
137MP0006036_abnormal_mitochondrial_physio0.64174260
138MP0003632_abnormal_nervous_system0.63041505
139MP0000470_abnormal_stomach_morphology0.62371436
140MP0001270_distended_abdomen0.62347533
141MP0003787_abnormal_imprinting0.62261339
142MP0000427_abnormal_hair_cycle0.61384732
143MP0002075_abnormal_coat/hair_pigmentati0.61187700
144MP0000604_amyloidosis0.60282452
145MP0001501_abnormal_sleep_pattern0.59115237
146MP0003122_maternal_imprinting0.56781588
147MP0001663_abnormal_digestive_system0.55750110
148MP0001145_abnormal_male_reproductive0.55688391
149MP0004142_abnormal_muscle_tone0.55552587
150MP0001485_abnormal_pinna_reflex0.55471412
151MP0005085_abnormal_gallbladder_physiolo0.54568625
152MP0002254_reproductive_system_inflammat0.53942397
153MP0003656_abnormal_erythrocyte_physiolo0.52104808
154MP0003690_abnormal_glial_cell0.52005221
155MP0004510_myositis0.51659538
156MP0002837_dystrophic_cardiac_calcinosis0.50109474
157MP0003123_paternal_imprinting0.49202074
158MP0002876_abnormal_thyroid_physiology0.48840452
159MP0004233_abnormal_muscle_weight0.44900664
160MP0005253_abnormal_eye_physiology0.44179831
161MP0002873_normal_phenotype0.43599714
162MP0002169_no_abnormal_phenotype0.43268553

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.46146144
2Genetic anticipation (HP:0003743)6.91521675
3Ulnar claw (HP:0001178)6.62018340
4Myotonia (HP:0002486)5.69864104
5Segmental peripheral demyelination/remyelination (HP:0003481)4.98302010
6Prostate neoplasm (HP:0100787)4.83274460
7Testicular atrophy (HP:0000029)4.82357553
8Gaze-evoked nystagmus (HP:0000640)4.80478448
9Sensory axonal neuropathy (HP:0003390)4.73069336
10Action tremor (HP:0002345)4.67315741
11Absent/shortened dynein arms (HP:0200106)4.56922508
12Dynein arm defect of respiratory motile cilia (HP:0012255)4.56922508
13Insidious onset (HP:0003587)4.27639718
14Termporal pattern (HP:0011008)4.27639718
15Dysmetric saccades (HP:0000641)4.23873553
16Foot dorsiflexor weakness (HP:0009027)4.15622320
17Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.74899324
18Short 1st metacarpal (HP:0010034)3.74899324
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.69272892
20Abnormality of the foot musculature (HP:0001436)3.68855567
21Hyperventilation (HP:0002883)3.64406249
22Amelogenesis imperfecta (HP:0000705)3.54805906
23Pheochromocytoma (HP:0002666)3.54639344
24Abnormality of pain sensation (HP:0010832)3.52347125
25Impaired pain sensation (HP:0007328)3.52347125
26Abnormality of the 1st metacarpal (HP:0010009)3.52025454
27Hammertoe (HP:0001765)3.46805176
28Focal motor seizures (HP:0011153)3.38325978
29Urinary urgency (HP:0000012)3.36076058
30Neuroendocrine neoplasm (HP:0100634)3.25143598
31Muscle stiffness (HP:0003552)3.24911472
32Dysdiadochokinesis (HP:0002075)3.24265583
33Abnormality of the proximal phalanges of the hand (HP:0009834)3.23862809
34Abnormality of secondary sexual hair (HP:0009888)3.23783464
35Abnormality of the axillary hair (HP:0100134)3.23783464
36Abnormality of the nasal septum (HP:0000419)3.19288129
37Infertility (HP:0000789)3.09775365
38Annular pancreas (HP:0001734)3.08198370
39Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.07414770
40Impaired smooth pursuit (HP:0007772)3.03484392
41Ankle clonus (HP:0011448)3.00988279
42Abnormal respiratory motile cilium morphology (HP:0005938)2.99480114
43Abnormal respiratory epithelium morphology (HP:0012253)2.99480114
44Onion bulb formation (HP:0003383)2.98421330
45Abnormality of the lower motor neuron (HP:0002366)2.96489766
46Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.96007730
47Hyperglycinuria (HP:0003108)2.95165975
48Limb dystonia (HP:0002451)2.94728680
49Short phalanx of the thumb (HP:0009660)2.94720529
50Pendular nystagmus (HP:0012043)2.93775228
51Steppage gait (HP:0003376)2.90675605
52Pancreatic cysts (HP:0001737)2.86147159
53Atonic seizures (HP:0010819)2.84023698
54Intrahepatic cholestasis (HP:0001406)2.81482588
55Abnormal respiratory motile cilium physiology (HP:0012261)2.79072491
56Azoospermia (HP:0000027)2.78770034
57Postural tremor (HP:0002174)2.77862835
58Nuclear cataract (HP:0100018)2.77719960
59Impaired vibration sensation in the lower limbs (HP:0002166)2.76696905
60Failure to thrive in infancy (HP:0001531)2.73200996
61Supranuclear gaze palsy (HP:0000605)2.70619205
62Congenital stationary night blindness (HP:0007642)2.70298388
63Glucose intolerance (HP:0000833)2.68802509
64Hypothermia (HP:0002045)2.68552409
65Spastic gait (HP:0002064)2.64355370
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.62129872
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.60432620
68Focal seizures (HP:0007359)2.59682541
69Nephronophthisis (HP:0000090)2.58793682
70Abnormality of serine family amino acid metabolism (HP:0010894)2.57280827
71Abnormality of glycine metabolism (HP:0010895)2.57280827
72Generalized hypopigmentation of hair (HP:0011358)2.56898189
73Abnormality of the prostate (HP:0008775)2.55639693
74Broad-based gait (HP:0002136)2.55356079
75Abnormality of the renal cortex (HP:0011035)2.54753184
76Clumsiness (HP:0002312)2.53877147
77Abnormal eating behavior (HP:0100738)2.53526242
78Impaired proprioception (HP:0010831)2.53225227
79Fair hair (HP:0002286)2.52321920
80Progressive sensorineural hearing impairment (HP:0000408)2.52318753
81Arthropathy (HP:0003040)2.51909760
82Fibular aplasia (HP:0002990)2.49886203
83Spinal canal stenosis (HP:0003416)2.49625626
84Abnormal tarsal ossification (HP:0008369)2.49444867
85Abnormal spermatogenesis (HP:0008669)2.47380231
86Retinal dysplasia (HP:0007973)2.45388521
87Hypoventilation (HP:0002791)2.43417008
88Keratoconus (HP:0000563)2.42081055
89Increased corneal curvature (HP:0100692)2.42081055
90Bronchomalacia (HP:0002780)2.41222596
91Ventricular fibrillation (HP:0001663)2.38426494
92Abnormality of the vocal cords (HP:0008777)2.37977596
933-Methylglutaconic aciduria (HP:0003535)2.37117056
94Abnormal hemoglobin (HP:0011902)2.36505766
95Impaired vibratory sensation (HP:0002495)2.34500650
96Ketoacidosis (HP:0001993)2.33238436
97Microretrognathia (HP:0000308)2.31052484
98Molar tooth sign on MRI (HP:0002419)2.31033842
99Abnormality of midbrain morphology (HP:0002418)2.31033842
100Protruding tongue (HP:0010808)2.30001494
101Abnormality of the renal medulla (HP:0100957)2.27891173
102Distal sensory impairment (HP:0002936)2.27527215
103Limb ataxia (HP:0002070)2.27324915
104Abnormality of the corticospinal tract (HP:0002492)2.25869707
105Peripheral hypomyelination (HP:0007182)2.24032133
106Ketosis (HP:0001946)2.22921171
107Generalized tonic-clonic seizures (HP:0002069)2.20618074
108Pancreatic fibrosis (HP:0100732)2.19684812
109Decreased motor nerve conduction velocity (HP:0003431)2.19534656
110Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.19482411
111Abnormality of ocular smooth pursuit (HP:0000617)2.19474089
112Visual hallucinations (HP:0002367)2.19102612
113Acute necrotizing encephalopathy (HP:0006965)2.18941267
114Urinary bladder sphincter dysfunction (HP:0002839)2.18286338
115Hypercortisolism (HP:0001578)2.17731507
116Neoplasm of the heart (HP:0100544)2.17148991
117True hermaphroditism (HP:0010459)2.15288456
118Abnormal ciliary motility (HP:0012262)2.14949243
119Absence seizures (HP:0002121)2.14198500
120Dialeptic seizures (HP:0011146)2.12693835
121Decreased circulating renin level (HP:0003351)2.11902293
122Peripheral demyelination (HP:0011096)2.09096379
123Abnormality of the hepatic vasculature (HP:0006707)2.09006936
124Cerebral hemorrhage (HP:0001342)2.08920916
125Chronic hepatic failure (HP:0100626)2.08514850
126Flat acetabular roof (HP:0003180)2.08102191
127Short tibia (HP:0005736)2.07838227
128Lower limb muscle weakness (HP:0007340)2.07824428
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06675135
130Abnormality of alanine metabolism (HP:0010916)2.06675135
131Hyperalaninemia (HP:0003348)2.06675135
132Chronic bronchitis (HP:0004469)2.05512344
133Acute encephalopathy (HP:0006846)2.03200618
134Type II lissencephaly (HP:0007260)2.02959016
135Abolished electroretinogram (ERG) (HP:0000550)2.02275858
136Dysmetria (HP:0001310)1.99458653
137Gonadotropin excess (HP:0000837)1.98286050
138Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97844972
139Renal tubular acidosis (HP:0001947)1.97730401
140Renal cortical cysts (HP:0000803)1.95394578
141Abnormal glucose tolerance (HP:0001952)1.95392627
142Epileptic encephalopathy (HP:0200134)1.94682199
143Bile duct proliferation (HP:0001408)1.92451112
144Abnormal biliary tract physiology (HP:0012439)1.92451112
145Prolonged QT interval (HP:0001657)1.92122196
146Chorioretinal atrophy (HP:0000533)1.90782200
147Scanning speech (HP:0002168)1.90543401
148Attenuation of retinal blood vessels (HP:0007843)1.90315782
149Anxiety (HP:0000739)1.90240120
150Short hallux (HP:0010109)1.90013325
151Febrile seizures (HP:0002373)1.89561235
152Torticollis (HP:0000473)1.89512560
153Morphological abnormality of the pyramidal tract (HP:0002062)1.88170743
154Increased CSF protein (HP:0002922)1.87591079
155Hypoplasia of the brainstem (HP:0002365)1.87147520
156Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87147520
157Craniofacial dystonia (HP:0012179)1.86798357
158Polyphagia (HP:0002591)1.84800496
159Cerebral hypomyelination (HP:0006808)1.84503029
160Neoplasm of the peripheral nervous system (HP:0100007)1.84293186
161Tubular atrophy (HP:0000092)1.84078134
162Hypoplasia of the uterus (HP:0000013)1.83285341
163Severe Myopia (HP:0011003)1.81649776
164Truncal ataxia (HP:0002078)1.81496362
165Broad metatarsal (HP:0001783)1.81191206
166Progressive macrocephaly (HP:0004481)1.79933999
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.79737968
168Abnormality of the parathyroid morphology (HP:0011766)1.79634076
169Hyperglycinemia (HP:0002154)1.79171699
170Progressive cerebellar ataxia (HP:0002073)1.79083013
171Progressive muscle weakness (HP:0003323)1.78801239
172Hypochromic microcytic anemia (HP:0004840)1.78770387
173Bradycardia (HP:0001662)1.78192978
174Large for gestational age (HP:0001520)1.77689549
175Neuroblastic tumors (HP:0004376)1.76908635
176Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.76908635
177Neuroblastoma (HP:0003006)1.76908635
178Primitive neuroectodermal tumor (HP:0030065)1.76908635
179Congenital, generalized hypertrichosis (HP:0004540)1.76762433
180Mitochondrial inheritance (HP:0001427)1.76163414
181Calf muscle hypertrophy (HP:0008981)1.75746289
182Bilateral microphthalmos (HP:0007633)1.75501590
183Aplasia/Hypoplasia of the hallux (HP:0008362)1.75187233
184Aplasia/Hypoplasia of the ulna (HP:0006495)1.73527496
185Tented upper lip vermilion (HP:0010804)1.73305784
186Cystic liver disease (HP:0006706)1.73174711
187Aplasia/Hypoplasia of the fibula (HP:0006492)1.70848578
188Decreased muscle mass (HP:0003199)1.68694055
189Hemiparesis (HP:0001269)1.68326928
190Prolonged partial thromboplastin time (HP:0003645)1.67752511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D6.81181314
2CAMK1G5.19929815
3AKT35.02346369
4PDK34.13121746
5PDK44.13121746
6MAP3K94.09672230
7LMTK23.69828324
8ARAF3.49037471
9MINK12.91357416
10MAP3K22.85364739
11GRK52.58768451
12KSR22.57415825
13PDK22.53576839
14NME22.47496103
15OXSR12.46754763
16ACVR1B2.38738577
17TESK12.33547768
18STK392.30990354
19LATS22.26625944
20TAOK32.19468818
21NTRK32.15004716
22CDK192.02548884
23BMPR1B2.01217567
24NTRK11.97075175
25PRKD31.96448501
26MAP4K21.92140688
27WNK41.89631014
28GRK11.83538133
29STK381.79903710
30WNK11.79086897
31TNK21.77541460
32EEF2K1.57029095
33ICK1.44257453
34RIPK41.43510005
35FER1.41044677
36MAP3K121.40492868
37PIM21.39683088
38NME11.37116661
39MAP2K41.36648311
40STK38L1.36568654
41MAP2K71.35092816
42MARK11.34386284
43PHKG11.33816924
44PHKG21.33816924
45MYLK1.33495101
46PRKD21.30971858
47LIMK11.30027850
48TGFBR11.28593235
49RET1.24515625
50SGK21.20658859
51UHMK11.20400643
52MAPKAPK31.19943330
53PRKAA21.17636192
54PNCK1.16678942
55MAPK131.16621714
56INSRR1.15213021
57MAP3K41.14809382
58PAK61.14541034
59CAMKK21.05223645
60CAMK11.03465545
61MAP2K11.03042816
62WNK31.02822203
63RPS6KA21.02706467
64ADRBK11.01252669
65PRKAA10.94906282
66MAP3K10.91444236
67STK110.90564595
68CDK50.90529080
69BRAF0.89323174
70MAP2K20.88138057
71PINK10.87270226
72PDK10.87116875
73ADRBK20.84365266
74PRKCI0.83172775
75CDK80.81783323
76MATK0.80730311
77TXK0.80365066
78PRKCG0.79817800
79MAP3K70.77413940
80ZAK0.71736543
81CHEK20.70155611
82PAK20.66855929
83SGK30.65356752
84MTOR0.64179054
85PAK30.63550444
86MKNK20.63188820
87ERBB20.62640270
88MAPK150.62026410
89NLK0.59426790
90BCR0.59418009
91SGK2230.58753526
92SGK4940.58753526
93PDPK10.58626377
94PRKG20.56614987
95MAP2K60.56096191
96EPHA30.55485594
97CDK140.55167936
98NUAK10.54858271
99STK30.53508088
100SGK10.49386883
101CDK150.47853830
102PTK2B0.46169926
103CDK180.44506522
104DAPK20.41635195
105CHUK0.41027129
106SCYL20.39451777
107TRIB30.38647899
108CAMK2A0.38437500
109NTRK20.38320000
110TLK10.36580095
111CDK11A0.36055631
112RAF10.32797401
113CAMKK10.32424684
114AURKA0.31506525
115MAPKAPK50.31023255
116TESK20.30720406
117TAOK10.30659672
118* PRKACA0.30195030
119BRSK20.29281617
120FRK0.29002394
121SRC0.28782804
122CDC42BPA0.28114011
123CSNK1A10.28108655
124MAPK100.27870054
125PRKCE0.27328955
126PRKACG0.27294570
127CSNK1A1L0.27230534
128PLK20.27119134
129TEC0.26745952
130GSK3A0.26423762
131CSNK1E0.26149887
132STK160.25534678
133CSNK1G20.24347884
134GRK70.24292395
135CASK0.23841084
136AKT10.23158968
137PIK3CA0.22573015
138GSK3B0.22561439
139TRPM70.22048113
140PRKCZ0.21499249
141PRKCA0.20947834
142PRKCB0.20616082
143RPS6KA30.20443745
144DMPK0.19372643
145PRKCH0.19017625
146IRAK20.18387916
147FYN0.18357460
148RPS6KA50.17498341
149MAPK10.17468430
150MARK20.17447681
151MAPK80.17299666
152DAPK10.16971453
153RPS6KC10.16881861
154RPS6KL10.16881861
155BCKDK0.15892117
156PRKACB0.15069061
157ALK0.14788591

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.79403715
2Oxidative phosphorylation_Homo sapiens_hsa001904.28948731
3Parkinsons disease_Homo sapiens_hsa050124.15917494
4Alzheimers disease_Homo sapiens_hsa050103.41938331
5Cardiac muscle contraction_Homo sapiens_hsa042603.38684264
6Huntingtons disease_Homo sapiens_hsa050162.98859060
7Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.78693357
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.75663172
9Synaptic vesicle cycle_Homo sapiens_hsa047212.65828026
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.61009048
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.43651271
12Linoleic acid metabolism_Homo sapiens_hsa005912.41470350
13Butanoate metabolism_Homo sapiens_hsa006502.29051948
14Caffeine metabolism_Homo sapiens_hsa002322.19526914
15Retinol metabolism_Homo sapiens_hsa008302.11396109
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.05789954
17ABC transporters_Homo sapiens_hsa020102.02550297
18Tryptophan metabolism_Homo sapiens_hsa003801.96155528
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93352076
20Dorso-ventral axis formation_Homo sapiens_hsa043201.91700168
21Renin-angiotensin system_Homo sapiens_hsa046141.84496665
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.82804042
23beta-Alanine metabolism_Homo sapiens_hsa004101.77701041
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68117160
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68017971
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64073651
27Sulfur relay system_Homo sapiens_hsa041221.60106969
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52322775
29Peroxisome_Homo sapiens_hsa041461.44529619
30Nicotine addiction_Homo sapiens_hsa050331.43502572
31Insulin secretion_Homo sapiens_hsa049111.42948233
32Long-term potentiation_Homo sapiens_hsa047201.39886631
33Arachidonic acid metabolism_Homo sapiens_hsa005901.33250414
34Olfactory transduction_Homo sapiens_hsa047401.32432027
35Mineral absorption_Homo sapiens_hsa049781.31898493
36Salivary secretion_Homo sapiens_hsa049701.30973834
37Pyruvate metabolism_Homo sapiens_hsa006201.30065443
38Glutamatergic synapse_Homo sapiens_hsa047241.29948295
39Taste transduction_Homo sapiens_hsa047421.27006465
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26277479
41Circadian entrainment_Homo sapiens_hsa047131.24867319
42Gastric acid secretion_Homo sapiens_hsa049711.23104721
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21455063
44Histidine metabolism_Homo sapiens_hsa003401.20250549
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18085044
46Lysine degradation_Homo sapiens_hsa003101.17937220
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16233229
48Phototransduction_Homo sapiens_hsa047441.13979251
49Arginine and proline metabolism_Homo sapiens_hsa003301.12191286
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11457437
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11272576
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.11167093
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10393015
54Glioma_Homo sapiens_hsa052141.10053163
55Fatty acid biosynthesis_Homo sapiens_hsa000611.08983852
56Ovarian steroidogenesis_Homo sapiens_hsa049131.08310238
57Dopaminergic synapse_Homo sapiens_hsa047281.06946102
58Estrogen signaling pathway_Homo sapiens_hsa049151.06938781
59Oocyte meiosis_Homo sapiens_hsa041141.05948992
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02686759
61Prostate cancer_Homo sapiens_hsa052151.01544644
62Melanoma_Homo sapiens_hsa052181.01323705
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.01106295
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00729460
65Morphine addiction_Homo sapiens_hsa050320.99559944
66Renin secretion_Homo sapiens_hsa049240.99421580
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98940246
68Bile secretion_Homo sapiens_hsa049760.98524924
69Cholinergic synapse_Homo sapiens_hsa047250.97563784
70Amphetamine addiction_Homo sapiens_hsa050310.94235945
71Gap junction_Homo sapiens_hsa045400.93843413
72Steroid biosynthesis_Homo sapiens_hsa001000.92523572
73Thyroid cancer_Homo sapiens_hsa052160.92203626
74Glucagon signaling pathway_Homo sapiens_hsa049220.91851291
75Vitamin digestion and absorption_Homo sapiens_hsa049770.91730247
76Tyrosine metabolism_Homo sapiens_hsa003500.91668798
77Fatty acid degradation_Homo sapiens_hsa000710.89302804
78* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87580093
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87006099
80Non-small cell lung cancer_Homo sapiens_hsa052230.85015178
81Ether lipid metabolism_Homo sapiens_hsa005650.83972925
82Thyroid hormone synthesis_Homo sapiens_hsa049180.82153901
83GnRH signaling pathway_Homo sapiens_hsa049120.80537842
84Complement and coagulation cascades_Homo sapiens_hsa046100.79122853
85Collecting duct acid secretion_Homo sapiens_hsa049660.74156690
86Bladder cancer_Homo sapiens_hsa052190.73742564
87GABAergic synapse_Homo sapiens_hsa047270.73047501
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71766223
89Fatty acid metabolism_Homo sapiens_hsa012120.70840179
90Phenylalanine metabolism_Homo sapiens_hsa003600.68921184
91Circadian rhythm_Homo sapiens_hsa047100.66068544
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65244453
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64053083
94AMPK signaling pathway_Homo sapiens_hsa041520.63486285
95Arginine biosynthesis_Homo sapiens_hsa002200.63370624
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63170213
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62716869
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.61093673
99Long-term depression_Homo sapiens_hsa047300.60754184
100Calcium signaling pathway_Homo sapiens_hsa040200.58961157
101Fatty acid elongation_Homo sapiens_hsa000620.57764750
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.56845809
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56541818
104Insulin resistance_Homo sapiens_hsa049310.56004103
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54390455
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.54010078
107Pancreatic secretion_Homo sapiens_hsa049720.52693468
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52518709
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.52468532
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52141410
111Serotonergic synapse_Homo sapiens_hsa047260.51393576
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51131837
113Propanoate metabolism_Homo sapiens_hsa006400.50882897
114VEGF signaling pathway_Homo sapiens_hsa043700.50683011
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48132695
116PPAR signaling pathway_Homo sapiens_hsa033200.47943018
117Melanogenesis_Homo sapiens_hsa049160.45131424
118cAMP signaling pathway_Homo sapiens_hsa040240.44289586
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43066723
120Vibrio cholerae infection_Homo sapiens_hsa051100.39507690
121Chemical carcinogenesis_Homo sapiens_hsa052040.39419628
122Insulin signaling pathway_Homo sapiens_hsa049100.39312732
123Prion diseases_Homo sapiens_hsa050200.38300505
124Salmonella infection_Homo sapiens_hsa051320.38204352
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37623250
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.36299183
127Proteasome_Homo sapiens_hsa030500.36088945
128Oxytocin signaling pathway_Homo sapiens_hsa049210.35957343
129Phagosome_Homo sapiens_hsa041450.34997582
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34960723
131Endometrial cancer_Homo sapiens_hsa052130.33868161
132Glycerolipid metabolism_Homo sapiens_hsa005610.33219545
133Metabolic pathways_Homo sapiens_hsa011000.31349515
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31283657
135Endocytosis_Homo sapiens_hsa041440.29765543
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29728077
137Nitrogen metabolism_Homo sapiens_hsa009100.29428998
138ErbB signaling pathway_Homo sapiens_hsa040120.29279420
139Cocaine addiction_Homo sapiens_hsa050300.28948291
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28503339
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28434083
142Glutathione metabolism_Homo sapiens_hsa004800.28025903
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.27695345
144Type II diabetes mellitus_Homo sapiens_hsa049300.27694599
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27264396
146Sphingolipid metabolism_Homo sapiens_hsa006000.24463684
147Selenocompound metabolism_Homo sapiens_hsa004500.24361946

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