TRPS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)7.62338078
2mesenchymal-epithelial cell signaling (GO:0060638)6.68346013
3regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.93751567
4regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.48188193
5desmosome organization (GO:0002934)5.13711492
6craniofacial suture morphogenesis (GO:0097094)5.13301631
7intestinal epithelial cell development (GO:0060576)4.95870708
8radial glial cell differentiation (GO:0060019)4.91811628
9epithelial cell maturation (GO:0002070)4.91286889
10prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.85271732
11ovulation from ovarian follicle (GO:0001542)4.68268820
12regulation of water loss via skin (GO:0033561)4.67951732
13iron ion import (GO:0097286)4.63957667
14bundle of His cell to Purkinje myocyte communication (GO:0086069)4.54707377
15dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.54619669
16branching involved in mammary gland duct morphogenesis (GO:0060444)4.43968376
17branching involved in salivary gland morphogenesis (GO:0060445)4.40769577
18cell proliferation involved in metanephros development (GO:0072203)4.37598085
19cell proliferation involved in kidney development (GO:0072111)4.36736739
20mammary gland alveolus development (GO:0060749)4.35604407
21keratinocyte development (GO:0003334)4.31436866
22positive regulation of keratinocyte differentiation (GO:0045618)4.29650908
23somite development (GO:0061053)4.25256052
24establishment of skin barrier (GO:0061436)4.20243121
25cranial suture morphogenesis (GO:0060363)4.19730136
26chondrocyte development (GO:0002063)4.15130883
27limb bud formation (GO:0060174)4.12041586
28activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.07367359
29mammary gland epithelial cell proliferation (GO:0033598)4.05198043
30negative regulation of keratinocyte proliferation (GO:0010839)4.04218917
31branching involved in prostate gland morphogenesis (GO:0060442)4.02163787
32mesenchymal cell proliferation (GO:0010463)3.96530953
33branching involved in labyrinthine layer morphogenesis (GO:0060670)3.92306990
34biotin metabolic process (GO:0006768)3.89060122
35dermatan sulfate biosynthetic process (GO:0030208)3.86535309
36regulation of hippo signaling (GO:0035330)3.77484924
37face development (GO:0060324)3.74254321
38bone trabecula formation (GO:0060346)3.72119823
39dermatan sulfate metabolic process (GO:0030205)3.71825113
40regulation of non-canonical Wnt signaling pathway (GO:2000050)3.70742919
41positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.63056437
42cardiac right ventricle morphogenesis (GO:0003215)3.61223433
43Golgi transport vesicle coating (GO:0048200)3.61162916
44COPI coating of Golgi vesicle (GO:0048205)3.61162916
45otic vesicle formation (GO:0030916)3.55000810
46prostate gland epithelium morphogenesis (GO:0060740)3.54753378
47sequestering of extracellular ligand from receptor (GO:0035581)3.49831382
48cellular response to cholesterol (GO:0071397)3.49144053
49regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.47658937
50genitalia morphogenesis (GO:0035112)3.43801014
51ectoderm development (GO:0007398)3.43642259
52ear development (GO:0043583)3.33275411
53regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.33084835
54hair follicle morphogenesis (GO:0031069)3.32449217
55phosphatidylinositol 3-kinase signaling (GO:0014065)3.31882502
56mesenchymal cell differentiation (GO:0048762)3.29967856
57regulation of establishment of cell polarity (GO:2000114)3.21280754
58regulation of protein polyubiquitination (GO:1902914)3.19610575
59glial cell migration (GO:0008347)3.18753062
60cell morphogenesis involved in neuron differentiation (GO:0048667)3.13458844
61positive regulation of epidermal cell differentiation (GO:0045606)3.13190806
62negative regulation of osteoblast proliferation (GO:0033689)3.12312569
63mesodermal cell differentiation (GO:0048333)3.12296473
64axis elongation (GO:0003401)3.06580750
65regulation of cell proliferation involved in kidney development (GO:1901722)3.04934798
66diol metabolic process (GO:0034311)3.04199258
67renal system development (GO:0072001)3.03813047
68negative regulation of stem cell proliferation (GO:2000647)3.03710698
69regulation of T cell tolerance induction (GO:0002664)3.02960323
70multicellular organismal water homeostasis (GO:0050891)3.01695549
71growth hormone receptor signaling pathway (GO:0060396)3.00188092
72regulation of osteoblast proliferation (GO:0033688)3.00151852
73keratinocyte proliferation (GO:0043616)2.99148425
74tight junction assembly (GO:0070830)2.98184104
75endocrine hormone secretion (GO:0060986)2.98030014
76cytoskeletal anchoring at plasma membrane (GO:0007016)2.98029668
77branch elongation of an epithelium (GO:0060602)2.95661615
78regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.92657788
79regulation of establishment or maintenance of cell polarity (GO:0032878)2.92047889
80endocardial cushion development (GO:0003197)2.90441299
81regulation of keratinocyte proliferation (GO:0010837)2.89804725
82type B pancreatic cell development (GO:0003323)2.89522573
83chondroitin sulfate catabolic process (GO:0030207)2.89423279
84somatic stem cell division (GO:0048103)2.88320044
85macroautophagy (GO:0016236)2.88181545
86collagen fibril organization (GO:0030199)2.86953602
87planar cell polarity pathway involved in neural tube closure (GO:0090179)2.84074213
88regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82806486
89positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.81336038
90mammary gland epithelial cell differentiation (GO:0060644)2.80675494
91sphingoid metabolic process (GO:0046519)2.80460857
92artery smooth muscle contraction (GO:0014824)2.80109534
93epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.79845220
94regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.79200017
95digestive tract morphogenesis (GO:0048546)2.75270983
96proximal/distal pattern formation (GO:0009954)2.74742814
97cellular response to sterol (GO:0036315)2.73943839
98heparin metabolic process (GO:0030202)2.73169871
99heparin biosynthetic process (GO:0030210)2.73169871
100positive regulation of fat cell differentiation (GO:0045600)2.72737492
101regulation of morphogenesis of a branching structure (GO:0060688)2.71894603
102negative regulation of smoothened signaling pathway (GO:0045879)2.69008016
103amyloid precursor protein catabolic process (GO:0042987)2.68900991
104negative regulation of chondrocyte differentiation (GO:0032331)2.68681167
105embryonic cranial skeleton morphogenesis (GO:0048701)2.68624963
106epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68246763
107apical protein localization (GO:0045176)2.68029799
108response to cholesterol (GO:0070723)2.67795769
109organ induction (GO:0001759)2.66900157
110cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.66229209
111sympathetic nervous system development (GO:0048485)2.65967328
112oocyte development (GO:0048599)2.64900482
113negative regulation of cartilage development (GO:0061037)2.64151191
114regulation of chemokine-mediated signaling pathway (GO:0070099)2.62791009
115asymmetric protein localization (GO:0008105)2.62253757
116chondroitin sulfate biosynthetic process (GO:0030206)2.62088714
117embryonic skeletal joint morphogenesis (GO:0060272)2.61808270
118myelination in peripheral nervous system (GO:0022011)2.61232538
119peripheral nervous system axon ensheathment (GO:0032292)2.61232538
120histone H3-K4 trimethylation (GO:0080182)2.61173425
121early endosome to late endosome transport (GO:0045022)2.61137286
122heart morphogenesis (GO:0003007)2.60942563
123cartilage condensation (GO:0001502)2.60375729
124cell aggregation (GO:0098743)2.60375729
125lung lobe morphogenesis (GO:0060463)2.60255268
126tonic smooth muscle contraction (GO:0014820)2.59820538
127hindlimb morphogenesis (GO:0035137)2.59426049
128prostate gland growth (GO:0060736)2.59224902
129regulation of clathrin-mediated endocytosis (GO:2000369)2.58838533
130regulation of histone H3-K27 methylation (GO:0061085)2.58383380
131regulation of fatty acid beta-oxidation (GO:0031998)2.57830880
132regulation of pigment cell differentiation (GO:0050932)2.57340003
133phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.56903501
134regulation of mesenchymal cell proliferation (GO:0010464)2.56703094
135positive regulation of mesenchymal cell proliferation (GO:0002053)2.56526176
136organ formation (GO:0048645)2.55686370
137trophectodermal cell differentiation (GO:0001829)2.54391013
138hair follicle development (GO:0001942)2.53368546
139cell surface receptor signaling pathway involved in heart development (GO:0061311)2.52976198
140endothelial cell chemotaxis (GO:0035767)2.52684619
141cellular response to growth hormone stimulus (GO:0071378)2.52365220
142cellular response to vitamin D (GO:0071305)2.52161467
143regulation of keratinocyte differentiation (GO:0045616)2.51827505
144cytoplasmic mRNA processing body assembly (GO:0033962)2.51705803
145face morphogenesis (GO:0060325)2.51667077
146positive regulation of macroautophagy (GO:0016239)2.51576873
147regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.49888572
148columnar/cuboidal epithelial cell development (GO:0002066)2.49395408
149organ growth (GO:0035265)2.49271834
150negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.48894595
151regulation of smoothened signaling pathway (GO:0008589)2.48838298
152positive regulation of protein import into nucleus, translocation (GO:0033160)2.48804965
153negative regulation of neurotransmitter secretion (GO:0046929)2.48760747
154insulin-like growth factor receptor signaling pathway (GO:0048009)2.48373833
155negative regulation of osteoblast differentiation (GO:0045668)2.48081967
156water homeostasis (GO:0030104)2.47454120
157peripheral nervous system development (GO:0007422)2.47445996
158RNA localization (GO:0006403)2.47282464
159convergent extension (GO:0060026)2.46956247
160negative regulation of kidney development (GO:0090185)2.46753053
161developmental induction (GO:0031128)2.46592921
162* chondrocyte differentiation (GO:0002062)2.45652530
163embryonic digestive tract morphogenesis (GO:0048557)2.45337174
164regulation of cardioblast differentiation (GO:0051890)2.44927984
165morphogenesis of an epithelial fold (GO:0060571)2.44560924
166branching involved in ureteric bud morphogenesis (GO:0001658)2.44468929
167cell-cell signaling involved in cell fate commitment (GO:0045168)2.44447548
168cellular response to antibiotic (GO:0071236)2.43516036
169chondrocyte proliferation (GO:0035988)2.43028385
170gland morphogenesis (GO:0022612)2.42042767
171protein localization to cell surface (GO:0034394)2.41725636
172cell differentiation involved in embryonic placenta development (GO:0060706)2.41430106
173kidney morphogenesis (GO:0060993)2.41130302
174cardiac ventricle morphogenesis (GO:0003208)2.41048956
175Golgi to endosome transport (GO:0006895)2.40872785
176interferon-gamma secretion (GO:0072643)2.38743705
177notochord development (GO:0030903)2.37827940
178epithelial to mesenchymal transition (GO:0001837)2.36665121
179JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.36351216
180regulation of tolerance induction (GO:0002643)2.33802575
181regulation of developmental pigmentation (GO:0048070)2.30753488
182bone morphogenesis (GO:0060349)2.30407462
183pattern specification involved in kidney development (GO:0061004)2.29979943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human9.06505657
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.37831719
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.42200895
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.05126161
5AR_21572438_ChIP-Seq_LNCaP_Human2.86893658
6* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.79881531
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.70113957
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.69696353
9ESR1_15608294_ChIP-ChIP_MCF-7_Human2.52621766
10RUNX1_27514584_Chip-Seq_MCF-7_Human2.42490548
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.37211853
12* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.32536016
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23480664
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23133398
15* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.17218603
16* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.15268908
17GATA3_24758297_ChIP-Seq_MCF-7_Human2.14842307
18GBX2_23144817_ChIP-Seq_PC3_Human2.14807473
19* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.08076558
20PIAS1_25552417_ChIP-Seq_VCAP_Human2.00892513
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97088945
22ELF5_23300383_ChIP-Seq_T47D_Human1.95998733
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.95161617
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.86386254
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81766018
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.72556668
27RXR_22108803_ChIP-Seq_LS180_Human1.70885298
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66654929
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65377495
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63529915
31TP53_18474530_ChIP-ChIP_U2OS_Human1.62379650
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62162978
33* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62111194
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60155905
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59793279
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59793279
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59099841
38TP53_16413492_ChIP-PET_HCT116_Human1.57981022
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57694929
40* AHR_22903824_ChIP-Seq_MCF-7_Human1.56404420
41CJUN_26792858_Chip-Seq_BT549_Human1.55481214
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54600831
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53645227
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53645227
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52791715
46* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52502589
47* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52026149
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.51927754
49* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.50417491
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48510888
51* ARNT_22903824_ChIP-Seq_MCF-7_Human1.47176810
52* P300_19829295_ChIP-Seq_ESCs_Human1.45096172
53TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.44765649
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42463573
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41498193
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41498193
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41116423
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41116423
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41061141
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40400002
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.40340207
62* SMAD4_21799915_ChIP-Seq_A2780_Human1.39335971
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38641710
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37892089
65TBX3_20139965_ChIP-Seq_ESCs_Mouse1.37590207
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37195541
67VDR_24787735_ChIP-Seq_THP-1_Human1.37037714
68TBX3_20139965_ChIP-Seq_MESCs_Mouse1.36704469
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36307801
70FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.35784822
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35733203
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35511403
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34331263
74* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31855586
75* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31412511
76* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30981702
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.30404917
78BRD4_25478319_ChIP-Seq_HGPS_Human1.29969043
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29912792
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.28954340
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.28876344
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26281034
83* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26066596
84GATA6_25053715_ChIP-Seq_YYC3_Human1.25716514
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.25606266
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25332511
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25091674
88GATA1_22025678_ChIP-Seq_K562_Human1.24476965
89* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23367537
90ER_23166858_ChIP-Seq_MCF-7_Human1.22474978
91* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22428454
92FOXA1_25552417_ChIP-Seq_VCAP_Human1.22303384
93FUS_26573619_Chip-Seq_HEK293_Human1.21980340
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21926631
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21608614
96* RACK7_27058665_Chip-Seq_MCF-7_Human1.21378802
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.21184707
98* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20690237
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18785425
100EGR1_19374776_ChIP-ChIP_THP-1_Human1.18219978
101* SOX2_20726797_ChIP-Seq_SW620_Human1.17827315
102BCAT_22108803_ChIP-Seq_LS180_Human1.17658187
103ISL1_27105846_Chip-Seq_CPCs_Mouse1.16934579
104STAT3_23295773_ChIP-Seq_U87_Human1.15260520
105* TP63_19390658_ChIP-ChIP_HaCaT_Human1.14782215
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.14071387
107* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12792986
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12727300
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12644048
110* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12127872
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11896014
112EWS_26573619_Chip-Seq_HEK293_Human1.10995158
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10843346
114TCF4_18268006_ChIP-ChIP_LS174T_Human1.09897963
115RUNX_20019798_ChIP-Seq_JUKART_Human1.09550160
116* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09030086
117* KLF5_25053715_ChIP-Seq_YYC3_Human1.08896148
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08489296
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08298046
120STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08121197
121* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08073850
122CDX2_20551321_ChIP-Seq_CACO-2_Human1.07997097
123WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07650365
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06772611
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06113734
126MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06065149
127TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05256514
128PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05003839
129JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04823714
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02883703
131ZNF263_19887448_ChIP-Seq_K562_Human1.02499272
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02217956
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01244509
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00079142
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99785239
136* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98743126
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.98300043
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97968684
139CHD1_26751641_Chip-Seq_LNCaP_Human0.97392530
140ESR2_21235772_ChIP-Seq_MCF-7_Human0.97099263
141FOXA2_19822575_ChIP-Seq_HepG2_Human0.96504140
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94659528
143* HOXB7_26014856_ChIP-Seq_BT474_Human0.91512983
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91340383
145TP63_23658742_ChIP-Seq_EP156T_Human0.90505820
146GATA4_25053715_ChIP-Seq_YYC3_Human0.88448651
147CLOCK_20551151_ChIP-Seq_293T_Human0.88339849
148PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86581151
149FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86287049
150* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82098173
151EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81275657
152* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80459767
153TAF15_26573619_Chip-Seq_HEK293_Human0.78395916
154PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78335006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.39734117
2MP0005503_abnormal_tendon_morphology4.16826905
3MP0010234_abnormal_vibrissa_follicle3.98894507
4MP0000566_synostosis3.74199675
5MP0001299_abnormal_eye_distance/3.38367872
6MP0000569_abnormal_digit_pigmentation3.37766844
7MP0002938_white_spotting3.17491850
8MP0009250_abnormal_appendicular_skeleto3.06641083
9MP0004134_abnormal_chest_morphology2.77696941
10MP0008438_abnormal_cutaneous_collagen2.66789501
11MP0005248_abnormal_Harderian_gland2.60362786
12MP0005083_abnormal_biliary_tract2.52825946
13MP0002796_impaired_skin_barrier2.51784435
14MP0004272_abnormal_basement_membrane2.30636200
15* MP0002282_abnormal_trachea_morphology2.28980388
16MP0003183_abnormal_peptide_metabolism2.16871603
17MP0001919_abnormal_reproductive_system2.15491807
18MP0005187_abnormal_penis_morphology2.08066542
19MP0004233_abnormal_muscle_weight2.07835728
20MP0000428_abnormal_craniofacial_morphol2.05289526
21MP0005508_abnormal_skeleton_morphology2.02723510
22MP0005408_hypopigmentation1.97577539
23MP0003937_abnormal_limbs/digits/tail_de1.96396698
24MP0002108_abnormal_muscle_morphology1.90210781
25MP0005076_abnormal_cell_differentiation1.88837171
26MP0001293_anophthalmia1.88064990
27MP0005257_abnormal_intraocular_pressure1.84559848
28* MP0000163_abnormal_cartilage_morphology1.84417779
29MP0005171_absent_coat_pigmentation1.81768447
30* MP0002115_abnormal_skeleton_extremities1.77145816
31MP0000579_abnormal_nail_morphology1.75139939
32MP0010030_abnormal_orbit_morphology1.74879969
33MP0003942_abnormal_urinary_system1.74338949
34MP0010352_gastrointestinal_tract_polyps1.70787803
35MP0002109_abnormal_limb_morphology1.70498644
36* MP0000377_abnormal_hair_follicle1.67934031
37MP0003191_abnormal_cellular_cholesterol1.66909082
38MP0003136_yellow_coat_color1.66734409
39MP0009384_cardiac_valve_regurgitation1.66630409
40MP0000762_abnormal_tongue_morphology1.65474504
41MP0009053_abnormal_anal_canal1.63377733
42MP0000432_abnormal_head_morphology1.62465793
43MP0001346_abnormal_lacrimal_gland1.62389602
44MP0005275_abnormal_skin_tensile1.61815607
45MP0002896_abnormal_bone_mineralization1.61096481
46MP0000049_abnormal_middle_ear1.61072277
47MP0000427_abnormal_hair_cycle1.58900766
48MP0000537_abnormal_urethra_morphology1.58429969
49MP0005646_abnormal_pituitary_gland1.57142154
50MP0003385_abnormal_body_wall1.56613005
51* MP0002116_abnormal_craniofacial_bone1.54293937
52MP0001873_stomach_inflammation1.54193331
53MP0001958_emphysema1.52741881
54MP0000383_abnormal_hair_follicle1.51046680
55MP0003935_abnormal_craniofacial_develop1.48897408
56MP0002933_joint_inflammation1.47779636
57MP0002009_preneoplasia1.46553132
58MP0000647_abnormal_sebaceous_gland1.43993920
59* MP0003755_abnormal_palate_morphology1.42277017
60* MP0002113_abnormal_skeleton_development1.41676690
61MP0005379_endocrine/exocrine_gland_phen1.40686356
62MP0002295_abnormal_pulmonary_circulatio1.35146786
63MP0002998_abnormal_bone_remodeling1.34024013
64MP0005390_skeleton_phenotype1.33686670
65MP0002166_altered_tumor_susceptibility1.33454046
66MP0001661_extended_life_span1.33084129
67MP0008057_abnormal_DNA_replication1.31621736
68MP0002089_abnormal_postnatal_growth/wei1.30098510
69MP0003941_abnormal_skin_development1.30014362
70MP0002177_abnormal_outer_ear1.29226911
71MP0002168_other_aberrant_phenotype1.29013027
72MP0002060_abnormal_skin_morphology1.28989896
73MP0001216_abnormal_epidermal_layer1.28628053
74MP0001879_abnormal_lymphatic_vessel1.23151751
75MP0003300_gastrointestinal_ulcer1.21333199
76MP0010678_abnormal_skin_adnexa1.20500677
77MP0003279_aneurysm1.19381266
78MP0005501_abnormal_skin_physiology1.18617776
79MP0000733_abnormal_muscle_development1.17035698
80MP0000516_abnormal_urinary_system1.16806998
81MP0005367_renal/urinary_system_phenotyp1.16806998
82MP0003938_abnormal_ear_development1.15618806
83MP0002249_abnormal_larynx_morphology1.15278809
84MP0002932_abnormal_joint_morphology1.13745274
85MP0010307_abnormal_tumor_latency1.12109595
86MP0003705_abnormal_hypodermis_morpholog1.11103838
87MP0001881_abnormal_mammary_gland1.10589212
88MP0003091_abnormal_cell_migration1.09587923
89MP0005389_reproductive_system_phenotype1.09581316
90MP0000627_abnormal_mammary_gland1.08785882
91MP0005075_abnormal_melanosome_morpholog1.07784921
92MP0003045_fibrosis1.02653633
93MP0004185_abnormal_adipocyte_glucose1.02181951
94MP0009780_abnormal_chondrocyte_physiolo1.02003588
95MP0003453_abnormal_keratinocyte_physiol1.01433632
96MP0000372_irregular_coat_pigmentation1.00673497
97MP0002254_reproductive_system_inflammat1.00218073
98MP0000613_abnormal_salivary_gland0.97807765
99MP0001243_abnormal_dermal_layer0.97268019
100MP0000371_diluted_coat_color0.95997439
101MP0000767_abnormal_smooth_muscle0.95891124
102MP0000467_abnormal_esophagus_morphology0.95271383
103MP0000462_abnormal_digestive_system0.95113584
104MP0003787_abnormal_imprinting0.94968582
105MP0003950_abnormal_plasma_membrane0.94414685
106MP0001727_abnormal_embryo_implantation0.91998649
107MP0010771_integument_phenotype0.90504265
108MP0001340_abnormal_eyelid_morphology0.90480025
109MP0002233_abnormal_nose_morphology0.89516923
110MP0003936_abnormal_reproductive_system0.89025562
111MP0002092_abnormal_eye_morphology0.84840808
112MP0001533_abnormal_skeleton_physiology0.84416290
113* MP0000367_abnormal_coat/_hair0.83018056
114MP0002751_abnormal_autonomic_nervous0.83001932
115MP0003566_abnormal_cell_adhesion0.82254389
116* MP0003795_abnormal_bone_structure0.81306427
117MP0002877_abnormal_melanocyte_morpholog0.80536945
118MP0000534_abnormal_ureter_morphology0.78975042
119* MP0002098_abnormal_vibrissa_morphology0.78162099
120* MP0001175_abnormal_lung_morphology0.77320985
121MP0004782_abnormal_surfactant_physiolog0.77196246
122MP0004381_abnormal_hair_follicle0.76598774
123MP0003638_abnormal_response/metabolism_0.75416427
124MP0009931_abnormal_skin_appearance0.73461991
125* MP0002114_abnormal_axial_skeleton0.73201546
126MP0000470_abnormal_stomach_morphology0.72858810
127MP0001666_abnormal_nutrient_absorption0.70161975
128MP0000681_abnormal_thyroid_gland0.69775978
129MP0004885_abnormal_endolymph0.69745672
130MP0002925_abnormal_cardiovascular_devel0.68565888
131MP0003943_abnormal_hepatobiliary_system0.68173393
132MP0003115_abnormal_respiratory_system0.67939009
133MP0001286_abnormal_eye_development0.67298096
134MP0000538_abnormal_urinary_bladder0.66996536
135MP0002006_tumorigenesis0.66738552
136MP0001270_distended_abdomen0.64983389
137MP0002111_abnormal_tail_morphology0.64091359
138MP0005310_abnormal_salivary_gland0.63863869
139MP0005409_darkened_coat_color0.63572605
140MP0001191_abnormal_skin_condition0.53049485
141MP0008961_abnormal_basal_metabolism0.52761895
142MP0001849_ear_inflammation0.52364086
143MP0004883_abnormal_blood_vessel0.52178853

Predicted human phenotypes

RankGene SetZ-score
1Vitreoretinal degeneration (HP:0000655)5.13751029
2Right ventricular cardiomyopathy (HP:0011663)5.09640559
3Lip pit (HP:0100267)4.86137137
4Midline defect of the nose (HP:0004122)4.69490008
5Abnormality of the parietal bone (HP:0002696)4.67283758
6Short 4th metacarpal (HP:0010044)4.56343463
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.56343463
8Abnormality of the nasal septum (HP:0000419)4.43209855
9Hypoplastic ischia (HP:0003175)4.39305777
10Curly hair (HP:0002212)4.12534369
11Trigonocephaly (HP:0000243)4.02001860
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.92729099
13Abnormality of the ischium (HP:0003174)3.91223363
14Epiphyseal dysplasia (HP:0002656)3.66269528
15Abnormality of incisor morphology (HP:0011063)3.56030057
16Aplasia involving bones of the upper limbs (HP:0009823)3.47991202
17Aplasia of the phalanges of the hand (HP:0009802)3.47991202
18Aplasia involving bones of the extremities (HP:0009825)3.47991202
19Nasolacrimal duct obstruction (HP:0000579)3.35208797
20* Deep philtrum (HP:0002002)3.33941775
21Macroorchidism (HP:0000053)3.33810848
22Pili torti (HP:0003777)3.23510248
23Flat acetabular roof (HP:0003180)3.22504082
24Shallow orbits (HP:0000586)3.22411413
25Oligomenorrhea (HP:0000876)3.20726885
26Abnormality of the astrocytes (HP:0100707)3.20590711
27Astrocytoma (HP:0009592)3.20590711
28Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.19159192
29Abnormality of the 4th metacarpal (HP:0010012)3.14161023
30Abnormality of the distal phalanx of the thumb (HP:0009617)3.07882194
31Abnormality of the distal phalanges of the toes (HP:0010182)3.01016849
32Abnormality of the middle phalanges of the toes (HP:0010183)3.00691686
33Pulmonary artery stenosis (HP:0004415)2.98454306
34Breast carcinoma (HP:0003002)2.91218216
35Glioma (HP:0009733)2.86792434
36Broad metatarsal (HP:0001783)2.84098112
37Germ cell neoplasia (HP:0100728)2.82818450
38Abnormality of the phalanges of the 2nd finger (HP:0009541)2.80532652
39* Sparse lateral eyebrow (HP:0005338)2.77521496
40Bell-shaped thorax (HP:0001591)2.74286817
41Alacrima (HP:0000522)2.73210604
42Synostosis involving the elbow (HP:0003938)2.71914295
43Humeroradial synostosis (HP:0003041)2.71914295
44White forelock (HP:0002211)2.71475932
45Abnormality of the lacrimal duct (HP:0011481)2.68159274
46Termporal pattern (HP:0011008)2.64099335
47Insidious onset (HP:0003587)2.64099335
48Abnormality of the incisor (HP:0000676)2.63661960
49Broad face (HP:0000283)2.63588250
50Abnormality of the nasolacrimal system (HP:0000614)2.62132023
51Anteriorly placed anus (HP:0001545)2.61299686
52Large earlobe (HP:0009748)2.59801602
53Aplasia cutis congenita (HP:0001057)2.58956793
54Mesomelia (HP:0003027)2.58716363
55* Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.54609515
56Irregular epiphyses (HP:0010582)2.53470336
57Coronal craniosynostosis (HP:0004440)2.51871102
58Severe Myopia (HP:0011003)2.50676837
59Toxemia of pregnancy (HP:0100603)2.49542657
60Broad hallux (HP:0010055)2.46900374
61Microglossia (HP:0000171)2.46618028
62Broad thumb (HP:0011304)2.46522118
63Depressed nasal tip (HP:0000437)2.45107059
64Abnormality of the frontal sinuses (HP:0002687)2.44211414
65Patchy hypopigmentation of hair (HP:0011365)2.37458432
66Broad toe (HP:0001837)2.36538861
67Missing ribs (HP:0000921)2.36320103
68* Abnormality of the epiphyses of the hand (HP:0005924)2.32538306
69Hamartoma of the eye (HP:0010568)2.32457223
70Mixed hearing impairment (HP:0000410)2.31294012
71Short middle phalanx of finger (HP:0005819)2.30169939
72Abnormality of the columella (HP:0009929)2.29632349
73Short phalanx of the thumb (HP:0009660)2.29213755
74Broad phalanx (HP:0006009)2.27604014
75Cupped ribs (HP:0000887)2.26468426
76Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.25897608
77Decreased lacrimation (HP:0000633)2.24503883
78* Abnormality of the middle phalanges of the hand (HP:0009833)2.23346982
79Broad long bones (HP:0005622)2.23056709
80Woolly hair (HP:0002224)2.22162789
81Hypotrichosis (HP:0001006)2.22144495
82Short nail (HP:0001799)2.20793883
83Thin bony cortex (HP:0002753)2.20228708
84Cervical subluxation (HP:0003308)2.19105228
85Tracheal stenosis (HP:0002777)2.19009008
86Abnormal hand bone ossification (HP:0010660)2.18744798
87Short hallux (HP:0010109)2.17960471
88Absent frontal sinuses (HP:0002688)2.17601762
89Abnormality of the pubic bones (HP:0003172)2.17015993
90Abnormal cartilage morphology (HP:0002763)2.16225897
91Hyporeflexia of lower limbs (HP:0002600)2.14912637
92Abnormality of the phalanges of the hallux (HP:0010057)2.14729015
93* Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.14280646
94Ependymoma (HP:0002888)2.14280464
95Tibial bowing (HP:0002982)2.13544956
96Advanced eruption of teeth (HP:0006288)2.13091516
97Abnormality of the 2nd finger (HP:0004100)2.12123028
98Turricephaly (HP:0000262)2.11544427
99Down-sloping shoulders (HP:0200021)2.11399943
100Hypoplastic labia majora (HP:0000059)2.10651368
101Natal tooth (HP:0000695)2.09133061
102Osteolytic defects of the hand bones (HP:0009699)2.09031130
103Osteolytic defects of the phalanges of the hand (HP:0009771)2.09031130
104Flattened epiphyses (HP:0003071)2.08945149
105Broad phalanges of the hand (HP:0009768)2.08409107
106Neonatal short-limb short stature (HP:0008921)2.07496157
107Abnormal ossification of hand bones (HP:0005921)2.07049824
108Aqueductal stenosis (HP:0002410)2.06992383
109Broad nasal tip (HP:0000455)2.06526630
110Abnormality of the parathyroid morphology (HP:0011766)2.06382156
111Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.06280260
112Abnormality of the diencephalon (HP:0010662)2.05378766
113Tubulointerstitial nephritis (HP:0001970)2.04398848
114Long clavicles (HP:0000890)2.03739332
115Limited elbow extension (HP:0001377)2.03525153
116Cone-rod dystrophy (HP:0000548)2.03482448
117Deformed sella turcica (HP:0002681)2.03475926
118Small epiphyses (HP:0010585)2.01884240
119Broad finger (HP:0001500)1.98107975
120* Exostoses (HP:0100777)1.98101583
121Hamartoma (HP:0010566)1.98075274
122Long nose (HP:0003189)1.97607306
123Aplasia/Hypoplasia of the hallux (HP:0008362)1.94312034
124Arterial tortuosity (HP:0005116)1.93872417
125Pheochromocytoma (HP:0002666)1.93302032
126Neoplasm of the heart (HP:0100544)1.93049847
127Short 1st metacarpal (HP:0010034)1.92422433
128Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.92422433
129Abnormality of the sella turcica (HP:0002679)1.92191752
130Abnormal tarsal ossification (HP:0008369)1.91474260
131Asymmetry of the thorax (HP:0001555)1.90884748
132Papillary thyroid carcinoma (HP:0002895)1.90811549
133Bronchomalacia (HP:0002780)1.89296674
134Septate vagina (HP:0001153)1.87854962
135* Abnormality of the proximal phalanges of the hand (HP:0009834)1.86544998
136Heterotopia (HP:0002282)1.86282405
137Abnormal hair laboratory examination (HP:0003328)1.85750629
138Milia (HP:0001056)1.85243338
139Abnormality of the labia majora (HP:0012881)1.84337627
140Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83518416
141Abnormality of the phalanges of the 5th finger (HP:0004213)1.83455152
142Partial duplication of the phalanx of hand (HP:0009999)1.82721571
143Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.81972694
144Vertebral hypoplasia (HP:0008417)1.81972694
145Amelogenesis imperfecta (HP:0000705)1.81140311
146Supernumerary ribs (HP:0005815)1.80979090
147Ectropion (HP:0000656)1.80462715
148Abnormality of the axillary hair (HP:0100134)1.80336065
149Abnormality of secondary sexual hair (HP:0009888)1.80336065
150Mild short stature (HP:0003502)1.79326048
151Decreased skull ossification (HP:0004331)1.78570681
152Tented upper lip vermilion (HP:0010804)1.76887323
153* Flat capital femoral epiphysis (HP:0003370)1.76139701
154Neoplasm of the oral cavity (HP:0100649)1.75584766
155Coarse hair (HP:0002208)1.75292776
156Limited hip movement (HP:0008800)1.74575278
157Abnormality of the humeroradial joint (HP:0100744)1.73831657
158Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.73379376
159Premature skin wrinkling (HP:0100678)1.73109658
160Abnormality of the fibula (HP:0002991)1.72874241
161Short thumb (HP:0009778)1.72583510
162Cystic hygroma (HP:0000476)1.72295030
163Follicular hyperkeratosis (HP:0007502)1.71422576
164Overgrowth (HP:0001548)1.71035457
165Recurrent bronchitis (HP:0002837)1.69919276
166Abnormality of the labia minora (HP:0012880)1.69758935
167Hypoplasia of the maxilla (HP:0000327)1.69648044
168Abnormal number of incisors (HP:0011064)1.69562626
169Acute myeloid leukemia (HP:0004808)1.68711619
170Chorioretinal atrophy (HP:0000533)1.67525717
171Severe short stature (HP:0003510)1.67261057
172Alopecia of scalp (HP:0002293)1.66687687
173Neoplasm of striated muscle (HP:0009728)1.66503813
174Wide anterior fontanel (HP:0000260)1.66129458
175Abnormality of the fingertips (HP:0001211)1.64902517
176Partial duplication of thumb phalanx (HP:0009944)1.64803683
177Mucopolysacchariduria (HP:0008155)1.63452236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK15.03974751
2LATS14.82925142
3FGFR24.10352796
4DDR23.96403101
5TRIB33.81533398
6EPHA23.44342853
7PKN23.19766490
8CAMK1D3.18882810
9CAMK1G2.86506870
10EPHA32.57435770
11NUAK12.56284549
12MAPKAPK32.27874814
13PIK3CA2.27105832
14SCYL22.25048675
15STK32.13784572
16NLK1.86365949
17MAPK151.80931333
18EPHB11.77113713
19RPS6KB21.62872399
20BMX1.62752523
21FGFR11.61824235
22PDGFRB1.57276021
23STK38L1.56561609
24TSSK61.53564103
25BRSK21.50444539
26CDK121.47907197
27MAP3K141.47421314
28CHUK1.44232112
29FGFR31.40727099
30JAK11.40436823
31MUSK1.40317505
32SGK21.38986866
33PDGFRA1.38803436
34EIF2AK11.37691839
35TESK11.35217953
36SGK31.26532804
37PNCK1.26114112
38MAP3K21.24633423
39WEE11.21546428
40RIPK11.16670857
41EEF2K1.14805202
42ERBB31.14769749
43MST1R1.12793784
44DMPK1.12252006
45IKBKB1.06098638
46EIF2AK21.02581954
47MET1.01085010
48NEK91.00254589
49ICK0.99689080
50FRK0.98570912
51CDK90.97803758
52ILK0.97156445
53BRD40.95115997
54PRKCI0.92218166
55MAP2K10.91286599
56JAK30.90965646
57MAP3K30.89820313
58STK390.86931675
59SGK2230.86514050
60SGK4940.86514050
61CDK70.85996445
62IRAK40.85993664
63PAK30.85354210
64FER0.84641088
65IRAK10.84448133
66BMPR20.84239060
67WNK10.83253336
68PBK0.82859536
69BMPR1B0.81741045
70PLK20.81346152
71NEK60.80006158
72FGFR40.78004643
73TRPM70.77522287
74TNK20.76459110
75GSK3A0.73748690
76PRKCE0.72436367
77INSRR0.72383237
78CDK60.72040573
79RIPK40.72020377
80CSF1R0.71918198
81SIK30.67240802
82IKBKE0.65466169
83RPS6KB10.64545299
84STK240.63880332
85PRKAA20.63197427
86PAK20.62869230
87IGF1R0.62634315
88TGFBR20.62365684
89MATK0.61528435
90CASK0.59897300
91ZAK0.59051106
92CSNK1A1L0.58732818
93MTOR0.57539270
94TTN0.57474001
95PRKD10.57428998
96RPS6KA20.56339163
97MARK30.55462497
98CDK30.54347660
99LRRK20.51590152
100MELK0.50893643
101TYK20.50441260
102SGK10.50209636
103CAMK40.50178185
104MAPK70.50115242
105ROCK10.49962045
106INSR0.48216352
107EIF2AK30.47786036
108PRKCQ0.47725508
109MST40.46991675
110MAP3K60.46230473
111ABL10.46142465
112AKT30.45427303
113GRK60.44684517
114MAPKAPK50.44646447
115FGR0.44512030
116KIT0.44390701
117NTRK10.43867048
118MAP3K130.43358844
119ERBB40.43328054
120CLK10.43029282
121MAPK10.42261516
122YES10.42049401
123IRAK30.41062929
124PTK60.40023378
125ERBB20.38274152
126MKNK20.38226914
127CDC42BPA0.38174303
128PRKAA10.36545941
129RET0.36254112
130HIPK20.34535475
131PIK3CG0.33907192
132EPHB20.33437148
133PTK20.33329934
134STK40.33017976
135TAF10.32599919
136LATS20.32444437
137MAPK30.32056681
138MARK20.31898349
139PRKD30.31514835
140MAPK80.31314151
141MAPK100.30055894
142ZAP700.30026925
143JAK20.29792860
144EPHA40.29637602

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.02511711
2Hedgehog signaling pathway_Homo sapiens_hsa043402.73787061
3ECM-receptor interaction_Homo sapiens_hsa045122.69335867
4Thyroid cancer_Homo sapiens_hsa052161.99458606
5TGF-beta signaling pathway_Homo sapiens_hsa043501.96922670
6Estrogen signaling pathway_Homo sapiens_hsa049151.78893392
7Fatty acid biosynthesis_Homo sapiens_hsa000611.78806206
8Adherens junction_Homo sapiens_hsa045201.77707953
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.73759792
10Malaria_Homo sapiens_hsa051441.72926432
11Sphingolipid metabolism_Homo sapiens_hsa006001.72292088
12Melanoma_Homo sapiens_hsa052181.67765183
13Proteoglycans in cancer_Homo sapiens_hsa052051.64443411
14Focal adhesion_Homo sapiens_hsa045101.64118103
15Prostate cancer_Homo sapiens_hsa052151.63227728
16ABC transporters_Homo sapiens_hsa020101.60781093
17Protein digestion and absorption_Homo sapiens_hsa049741.58002555
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.57590016
19Circadian rhythm_Homo sapiens_hsa047101.46512853
20Small cell lung cancer_Homo sapiens_hsa052221.45394381
21Longevity regulating pathway - mammal_Homo sapiens_hsa042111.44150534
22Hippo signaling pathway_Homo sapiens_hsa043901.43471372
23MicroRNAs in cancer_Homo sapiens_hsa052061.42696304
24Wnt signaling pathway_Homo sapiens_hsa043101.41132398
25Non-small cell lung cancer_Homo sapiens_hsa052231.40999040
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37966192
27Pathways in cancer_Homo sapiens_hsa052001.34133068
28Toxoplasmosis_Homo sapiens_hsa051451.33910233
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32219440
30Inositol phosphate metabolism_Homo sapiens_hsa005621.31438550
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30560667
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29911281
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24303580
34Amoebiasis_Homo sapiens_hsa051461.23593138
35Leishmaniasis_Homo sapiens_hsa051401.21589289
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20878030
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20358417
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20169028
39Osteoclast differentiation_Homo sapiens_hsa043801.19008639
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17980799
41Pancreatic cancer_Homo sapiens_hsa052121.17855238
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17801845
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.17231284
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16228004
45Chronic myeloid leukemia_Homo sapiens_hsa052201.15660741
46Viral myocarditis_Homo sapiens_hsa054161.15423983
47Colorectal cancer_Homo sapiens_hsa052101.15265847
48Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12852697
49TNF signaling pathway_Homo sapiens_hsa046681.12583071
50Tight junction_Homo sapiens_hsa045301.08310999
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07905063
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07037399
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.06169453
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04761639
55VEGF signaling pathway_Homo sapiens_hsa043701.01632200
56Lysine degradation_Homo sapiens_hsa003101.00201876
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99897464
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99695768
59Bladder cancer_Homo sapiens_hsa052190.99632277
60Dorso-ventral axis formation_Homo sapiens_hsa043200.94673309
61Endocytosis_Homo sapiens_hsa041440.94083069
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94015456
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.92405310
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92248831
65Dilated cardiomyopathy_Homo sapiens_hsa054140.92139508
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91570015
67Measles_Homo sapiens_hsa051620.91517279
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90604456
69Hepatitis B_Homo sapiens_hsa051610.89908032
70Tuberculosis_Homo sapiens_hsa051520.89286411
71Renal cell carcinoma_Homo sapiens_hsa052110.87199839
72Rheumatoid arthritis_Homo sapiens_hsa053230.86960552
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86232228
74Endometrial cancer_Homo sapiens_hsa052130.86103124
75ErbB signaling pathway_Homo sapiens_hsa040120.86084685
76Rap1 signaling pathway_Homo sapiens_hsa040150.84919134
77Axon guidance_Homo sapiens_hsa043600.83133748
78Glioma_Homo sapiens_hsa052140.82915032
79cAMP signaling pathway_Homo sapiens_hsa040240.79823730
80MAPK signaling pathway_Homo sapiens_hsa040100.79692045
81Melanogenesis_Homo sapiens_hsa049160.78728785
82Acute myeloid leukemia_Homo sapiens_hsa052210.77936016
83Type II diabetes mellitus_Homo sapiens_hsa049300.77781037
84Insulin signaling pathway_Homo sapiens_hsa049100.76986549
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76827380
86Lysosome_Homo sapiens_hsa041420.76342418
87Ras signaling pathway_Homo sapiens_hsa040140.76263433
88Prolactin signaling pathway_Homo sapiens_hsa049170.76092549
89HTLV-I infection_Homo sapiens_hsa051660.75752870
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75624977
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74574855
92Chemokine signaling pathway_Homo sapiens_hsa040620.72744528
93Allograft rejection_Homo sapiens_hsa053300.72332446
94African trypanosomiasis_Homo sapiens_hsa051430.70633742
95Nitrogen metabolism_Homo sapiens_hsa009100.69695274
96Graft-versus-host disease_Homo sapiens_hsa053320.69005368
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.68223774
98Influenza A_Homo sapiens_hsa051640.67596792
99FoxO signaling pathway_Homo sapiens_hsa040680.67537021
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66404636
101Insulin resistance_Homo sapiens_hsa049310.66116238
102Choline metabolism in cancer_Homo sapiens_hsa052310.66038259
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.65831055
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65524193
105Ovarian steroidogenesis_Homo sapiens_hsa049130.64582474
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63561497
107B cell receptor signaling pathway_Homo sapiens_hsa046620.63526858
108Phagosome_Homo sapiens_hsa041450.63382919
109Notch signaling pathway_Homo sapiens_hsa043300.61609332
110GnRH signaling pathway_Homo sapiens_hsa049120.60768084
111Salmonella infection_Homo sapiens_hsa051320.60004547
112N-Glycan biosynthesis_Homo sapiens_hsa005100.59934442
113Sulfur metabolism_Homo sapiens_hsa009200.59492238
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59472944
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.59293520
116Caffeine metabolism_Homo sapiens_hsa002320.59017221
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58936496
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58090521
119Hepatitis C_Homo sapiens_hsa051600.57985195
120Pertussis_Homo sapiens_hsa051330.56309870
121Alcoholism_Homo sapiens_hsa050340.55284528
122T cell receptor signaling pathway_Homo sapiens_hsa046600.55264597
123Steroid biosynthesis_Homo sapiens_hsa001000.54914257
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.54141335
125Renin secretion_Homo sapiens_hsa049240.53976099
126mTOR signaling pathway_Homo sapiens_hsa041500.53930998
127Platelet activation_Homo sapiens_hsa046110.53736979
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53594219
129HIF-1 signaling pathway_Homo sapiens_hsa040660.53534559
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53236547
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.52264489
132Herpes simplex infection_Homo sapiens_hsa051680.50223657
133Hematopoietic cell lineage_Homo sapiens_hsa046400.50084138
134AMPK signaling pathway_Homo sapiens_hsa041520.48686874
135Apoptosis_Homo sapiens_hsa042100.47998961
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.47047123

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