TRPV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of potassium ion transmembrane transporter activity (GO:1901018)8.30301514
2detection of temperature stimulus involved in sensory perception of pain (GO:0050965)8.19483119
3detection of temperature stimulus involved in sensory perception (GO:0050961)8.19483119
4positive regulation of steroid hormone secretion (GO:2000833)7.74053420
5regulation of glucocorticoid secretion (GO:2000849)7.63728130
6detection of temperature stimulus (GO:0016048)7.43178465
7regulation of corticosteroid hormone secretion (GO:2000846)6.46985886
8negative regulation of calcium ion transport into cytosol (GO:0010523)6.40593387
9negative regulation of dendrite morphogenesis (GO:0050774)6.10825391
10urinary tract smooth muscle contraction (GO:0014848)5.99222207
11regulation of glucocorticoid metabolic process (GO:0031943)5.91871863
12regulation of cell maturation (GO:1903429)5.54274106
13positive regulation of potassium ion transmembrane transport (GO:1901381)5.53643182
14peripheral nervous system neuron development (GO:0048935)5.47096377
15response to pain (GO:0048265)5.31480593
16peristalsis (GO:0030432)5.27425439
17neuronal action potential (GO:0019228)5.01590287
18positive regulation of hair cycle (GO:0042635)5.00458201
19positive regulation of hair follicle development (GO:0051798)5.00458201
20regulation of steroid hormone secretion (GO:2000831)4.89823911
21neurofilament cytoskeleton organization (GO:0060052)4.86234475
22neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.77154027
23behavioral response to nicotine (GO:0035095)4.68927675
24response to pheromone (GO:0019236)4.37292002
25negative regulation of heart rate (GO:0010459)4.24005888
26cell migration in hindbrain (GO:0021535)4.21550030
27cilium or flagellum-dependent cell motility (GO:0001539)4.17433469
28behavioral response to pain (GO:0048266)4.13777564
29proline transport (GO:0015824)4.12051673
30drug catabolic process (GO:0042737)4.00776954
31exogenous drug catabolic process (GO:0042738)4.00159121
32positive regulation of synaptic transmission, GABAergic (GO:0032230)3.97356189
33negative regulation of dendrite development (GO:2000171)3.96228401
34sympathetic nervous system development (GO:0048485)3.94693465
35positive regulation of potassium ion transport (GO:0043268)3.89726871
36negative regulation of microtubule polymerization (GO:0031115)3.87866917
37regulation of hair follicle development (GO:0051797)3.81746498
38tachykinin receptor signaling pathway (GO:0007217)3.79944966
39regulation of potassium ion transmembrane transporter activity (GO:1901016)3.78166779
40negative regulation of neurological system process (GO:0031645)3.75822522
41response to water (GO:0009415)3.74836677
42seminiferous tubule development (GO:0072520)3.74232565
43indole-containing compound catabolic process (GO:0042436)3.71063081
44indolalkylamine catabolic process (GO:0046218)3.71063081
45tryptophan catabolic process (GO:0006569)3.71063081
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.70062294
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.66598680
48L-fucose catabolic process (GO:0042355)3.60205194
49fucose catabolic process (GO:0019317)3.60205194
50L-fucose metabolic process (GO:0042354)3.60205194
51S-adenosylmethionine metabolic process (GO:0046500)3.58767633
52activation of protein kinase A activity (GO:0034199)3.55517076
53positive regulation of action potential (GO:0045760)3.55098397
54hindbrain development (GO:0030902)3.53568951
55kynurenine metabolic process (GO:0070189)3.52982672
56establishment of mitochondrion localization (GO:0051654)3.50027706
57cellular ketone body metabolic process (GO:0046950)3.50019374
58cAMP-mediated signaling (GO:0019933)3.49751303
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.47186481
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.46185851
61multicellular organismal response to stress (GO:0033555)3.45306432
62histamine secretion (GO:0001821)3.44276615
63pyrimidine nucleobase catabolic process (GO:0006208)3.44219992
64establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.43607235
65mitochondrion transport along microtubule (GO:0047497)3.43607235
66phasic smooth muscle contraction (GO:0014821)3.41299661
67membrane depolarization during action potential (GO:0086010)3.34935304
68presynaptic membrane assembly (GO:0097105)3.30281140
69indolalkylamine metabolic process (GO:0006586)3.28779415
70regulation of potassium ion transmembrane transport (GO:1901379)3.26743280
71postsynaptic membrane organization (GO:0001941)3.25789193
72tryptophan metabolic process (GO:0006568)3.22609285
73auditory behavior (GO:0031223)3.20877600
74negative regulation of cell size (GO:0045792)3.19973529
75negative regulation of homotypic cell-cell adhesion (GO:0034111)3.18439003
76negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.16572863
77negative regulation of Ras GTPase activity (GO:0034261)3.16114882
78nucleobase catabolic process (GO:0046113)3.14883896
79glutamate secretion (GO:0014047)3.13598619
80presynaptic membrane organization (GO:0097090)3.12646326
81piRNA metabolic process (GO:0034587)3.10184628
82protein localization to synapse (GO:0035418)3.09874042
83gamma-aminobutyric acid transport (GO:0015812)3.07775436
84positive regulation of cardiac muscle hypertrophy (GO:0010613)3.07481464
85positive regulation of muscle hypertrophy (GO:0014742)3.07481464
86oxidative demethylation (GO:0070989)3.07439630
87detection of light stimulus involved in visual perception (GO:0050908)3.06475905
88detection of light stimulus involved in sensory perception (GO:0050962)3.06475905
89negative regulation of translation, ncRNA-mediated (GO:0040033)3.05173363
90regulation of translation, ncRNA-mediated (GO:0045974)3.05173363
91negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.05173363
92ketone body metabolic process (GO:1902224)3.04330455
93phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.03533644
94C4-dicarboxylate transport (GO:0015740)3.03265941
95neuromuscular synaptic transmission (GO:0007274)3.02961397
96cornea development in camera-type eye (GO:0061303)3.02185812
97G-protein coupled receptor internalization (GO:0002031)3.01482845
98peripheral nervous system development (GO:0007422)2.99357738
99activation of adenylate cyclase activity (GO:0007190)2.99084966
100regulation of amyloid precursor protein catabolic process (GO:1902991)2.96443988
101regulation of triglyceride catabolic process (GO:0010896)2.96230942
102axon cargo transport (GO:0008088)2.96003425
103neuronal action potential propagation (GO:0019227)2.94731580
104aromatic amino acid family catabolic process (GO:0009074)2.93673877
105regulation of synaptic vesicle exocytosis (GO:2000300)2.93171117
106amine catabolic process (GO:0009310)2.92162848
107cellular biogenic amine catabolic process (GO:0042402)2.92162848
108regulation of endocrine process (GO:0044060)2.91787614
109regulation of collateral sprouting (GO:0048670)2.90355201
110positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90004016
111reflex (GO:0060004)2.89242370
112axonemal dynein complex assembly (GO:0070286)2.88643868
113nephron tubule morphogenesis (GO:0072078)2.88418665
114nephron epithelium morphogenesis (GO:0072088)2.88418665
115positive regulation of digestive system process (GO:0060456)2.88281499
116startle response (GO:0001964)2.87754343
117regulation of cilium movement (GO:0003352)2.85603229
118regulation of platelet aggregation (GO:0090330)2.85255609
119negative regulation of membrane potential (GO:0045837)2.85125451
120primary amino compound metabolic process (GO:1901160)2.84583047
121epithelial cilium movement (GO:0003351)2.83975718
122bundle of His cell to Purkinje myocyte communication (GO:0086069)2.83764080
123retinal ganglion cell axon guidance (GO:0031290)2.83206416
124kidney morphogenesis (GO:0060993)2.82464914
125cell communication involved in cardiac conduction (GO:0086065)2.82438779
126sensory perception of pain (GO:0019233)2.82341066
127indole-containing compound metabolic process (GO:0042430)2.80515951
128positive regulation of adenylate cyclase activity (GO:0045762)2.78941469
129negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.77492424
130head development (GO:0060322)2.76044657
131cyclic-nucleotide-mediated signaling (GO:0019935)2.75965391
132glycerophospholipid catabolic process (GO:0046475)2.75489796
133synaptic vesicle maturation (GO:0016188)2.75307101
134drinking behavior (GO:0042756)2.72711545
135adenosine metabolic process (GO:0046085)2.72311043
136regulation of action potential (GO:0098900)2.72159429
137positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.72045989
138amino acid salvage (GO:0043102)2.71661921
139L-methionine salvage (GO:0071267)2.71661921
140L-methionine biosynthetic process (GO:0071265)2.71661921
141regulation of dopamine secretion (GO:0014059)2.71294043
142glyoxylate metabolic process (GO:0046487)2.70580040
143action potential (GO:0001508)2.70273576
144regulation of protein kinase A signaling (GO:0010738)2.69650260
145water-soluble vitamin biosynthetic process (GO:0042364)2.69626697
146microtubule polymerization or depolymerization (GO:0031109)2.66860315
147protein maturation by protein folding (GO:0022417)2.66359536
148plasma membrane repair (GO:0001778)2.66255326
149histamine transport (GO:0051608)2.65069455
150negative regulation of protein polymerization (GO:0032272)2.64765733
151negative regulation of cation channel activity (GO:2001258)2.64653475
152neurotransmitter-gated ion channel clustering (GO:0072578)2.64497063
153flavonoid metabolic process (GO:0009812)2.64382940
154regulation of nuclear cell cycle DNA replication (GO:0033262)2.63397227
155ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.63218943
156positive regulation of vasodilation (GO:0045909)2.61562827
157thyroid hormone metabolic process (GO:0042403)2.60012569
158neuropeptide signaling pathway (GO:0007218)2.59967113
159regulation of potassium ion transport (GO:0043266)2.59553875
160insulin secretion (GO:0030073)2.59358691
161negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59093185
162regulation of short-term neuronal synaptic plasticity (GO:0048172)2.58842671
163innervation (GO:0060384)2.58501618
164parturition (GO:0007567)2.57820089
165detection of mechanical stimulus involved in sensory perception (GO:0050974)2.57768950
166actin filament capping (GO:0051693)2.57741263
167sensory perception of taste (GO:0050909)2.57175513
168protein polyglutamylation (GO:0018095)2.56715838
169mechanosensory behavior (GO:0007638)2.56246432
170sulfation (GO:0051923)2.56069286
171positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.54284749
172spinal cord development (GO:0021510)2.53011790
173behavioral response to ethanol (GO:0048149)2.52396283
174regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51571124
175serotonin metabolic process (GO:0042428)2.51565144
176arginine metabolic process (GO:0006525)2.49213791
177epoxygenase P450 pathway (GO:0019373)2.48968244
178L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47425724
179membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.46801559
180axoneme assembly (GO:0035082)2.46401424
181negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46358442
182synaptic transmission, cholinergic (GO:0007271)2.45855841
183drug metabolic process (GO:0017144)2.44490560
184nonmotile primary cilium assembly (GO:0035058)2.42907256
185endocrine pancreas development (GO:0031018)2.42847954
186multicellular organism reproduction (GO:0032504)2.42833167
187positive regulation of sodium ion transmembrane transport (GO:1902307)2.41413168
188uterus development (GO:0060065)2.40284280
189neuron cell-cell adhesion (GO:0007158)2.39538407
190regulation of microtubule-based movement (GO:0060632)2.38125952
191negative regulation of telomere maintenance (GO:0032205)2.37509017
192positive regulation of fatty acid transport (GO:2000193)2.36269345
193brain morphogenesis (GO:0048854)2.35399264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.33799669
2ZNF274_21170338_ChIP-Seq_K562_Hela3.64110607
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.25968633
4EZH2_22144423_ChIP-Seq_EOC_Human2.99231521
5IGF1R_20145208_ChIP-Seq_DFB_Human2.75271394
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.72447137
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62849193
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61937351
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57977155
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.47460561
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.30597147
12NR3C1_23031785_ChIP-Seq_PC12_Mouse2.28692899
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24617998
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22806824
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21790714
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.21549987
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21243471
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.18942237
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15853443
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14625569
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09807808
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08826958
23* REST_21632747_ChIP-Seq_MESCs_Mouse2.07273556
24WT1_19549856_ChIP-ChIP_CCG9911_Human2.01040801
25TAF15_26573619_Chip-Seq_HEK293_Human1.97342699
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95723335
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.89032167
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86371011
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86371011
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85107626
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81979886
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78918168
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77596905
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.75666511
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66850946
36ER_23166858_ChIP-Seq_MCF-7_Human1.66825107
37GBX2_23144817_ChIP-Seq_PC3_Human1.65245653
38ZNF263_19887448_ChIP-Seq_K562_Human1.63225049
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61919551
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59264425
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52520759
42VDR_22108803_ChIP-Seq_LS180_Human1.52454739
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51336763
44FUS_26573619_Chip-Seq_HEK293_Human1.50938667
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50620518
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50441182
47SMAD4_21799915_ChIP-Seq_A2780_Human1.49665078
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49101492
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48747533
50BCAT_22108803_ChIP-Seq_LS180_Human1.48234846
51EWS_26573619_Chip-Seq_HEK293_Human1.47909422
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.47489365
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.45803735
54* CTCF_27219007_Chip-Seq_Bcells_Human1.44709001
55TCF4_23295773_ChIP-Seq_U87_Human1.43247368
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42816049
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42493740
58IRF1_19129219_ChIP-ChIP_H3396_Human1.42458112
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41407148
60AR_21572438_ChIP-Seq_LNCaP_Human1.40428052
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.38698522
62AHR_22903824_ChIP-Seq_MCF-7_Human1.38490382
63CBP_20019798_ChIP-Seq_JUKART_Human1.38284231
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38284231
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.37136253
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37136180
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.35862824
68DROSHA_22980978_ChIP-Seq_HELA_Human1.35855069
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.34282242
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.32779875
71KDM2B_26808549_Chip-Seq_K562_Human1.32652777
72TP53_16413492_ChIP-PET_HCT116_Human1.30649018
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.30399178
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30280687
75AR_25329375_ChIP-Seq_VCAP_Human1.29948356
76TCF4_22108803_ChIP-Seq_LS180_Human1.28928051
77TET1_21490601_ChIP-Seq_MESCs_Mouse1.28091522
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27117216
79SOX2_20726797_ChIP-Seq_SW620_Human1.26985019
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26810998
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26474386
82P300_19829295_ChIP-Seq_ESCs_Human1.26036826
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25560077
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25462340
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25356708
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25356708
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24962714
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23785434
89RXR_22108803_ChIP-Seq_LS180_Human1.22364916
90EGR1_19032775_ChIP-ChIP_M12_Human1.22217526
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21999087
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21602367
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21401109
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21320791
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20407181
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19875948
97TP53_22573176_ChIP-Seq_HFKS_Human1.19808846
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.18344676
99NCOR_22424771_ChIP-Seq_293T_Human1.17624309
100RNF2_27304074_Chip-Seq_NSC_Mouse1.17613589
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16959104
102RUNX2_22187159_ChIP-Seq_PCA_Human1.16903686
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15880965
104ERA_21632823_ChIP-Seq_H3396_Human1.14898626
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14756307
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.12942108
107* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12229516
108HOXB7_26014856_ChIP-Seq_BT474_Human1.11765410
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10651935
110KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10318235
111* KDM2B_26808549_Chip-Seq_REH_Human1.10108593
112SMAD3_21741376_ChIP-Seq_ESCs_Human1.09422652
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.09394859
114GATA3_21878914_ChIP-Seq_MCF-7_Human1.09271722
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.09271606
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.08469019
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08469019
118RARB_27405468_Chip-Seq_BRAIN_Mouse1.08388960
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08088877
120KLF4_19829295_ChIP-Seq_ESCs_Human1.07493826
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07186945
122MYC_19829295_ChIP-Seq_ESCs_Human1.05609905
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05009774
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.04256466
125NANOG_19829295_ChIP-Seq_ESCs_Human1.04172782
126SOX2_19829295_ChIP-Seq_ESCs_Human1.04172782
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04054530
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03851054
129CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03593632
130JUN_21703547_ChIP-Seq_K562_Human1.02121801
131RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00028274
132FLI1_21867929_ChIP-Seq_TH2_Mouse0.99406764
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99376375
134SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99076012
135CJUN_26792858_Chip-Seq_BT549_Human0.98613318
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98090076
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.97483010
138OCT4_20526341_ChIP-Seq_ESCs_Human0.95714692
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.94715189
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.94402749
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93902994
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.93332679
143AR_20517297_ChIP-Seq_VCAP_Human0.93240519
144FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92698735
145NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92224939
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92020485
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92020485
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91728802
149KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91398168
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91323742
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91109272
152CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90953171
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90719526
154SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90131683
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89968027
156ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89834398
157IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89751228
158STAT3_23295773_ChIP-Seq_U87_Human0.89408091
159EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89391276
160CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89347121
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87816544
162TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87580976
163CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87329309
164PRDM14_20953172_ChIP-Seq_ESCs_Human0.86956497
165PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.86319123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system8.27215117
2* MP0002735_abnormal_chemical_nociception6.86452649
3* MP0001968_abnormal_touch/_nociception5.37718694
4MP0004270_analgesia5.02475582
5MP0006276_abnormal_autonomic_nervous4.85286016
6MP0002736_abnormal_nociception_after4.71093448
7MP0002163_abnormal_gland_morphology4.41535316
8MP0003195_calcinosis4.02355487
9MP0003787_abnormal_imprinting3.84455771
10* MP0002733_abnormal_thermal_nociception3.51752025
11* MP0001970_abnormal_pain_threshold3.21884760
12* MP0002734_abnormal_mechanical_nocicepti3.17993828
13MP0005379_endocrine/exocrine_gland_phen2.77206893
14MP0008875_abnormal_xenobiotic_pharmacok2.63932141
15MP0002751_abnormal_autonomic_nervous2.62793167
16MP0005646_abnormal_pituitary_gland2.42924390
17MP0002102_abnormal_ear_morphology2.42227830
18MP0002876_abnormal_thyroid_physiology2.39293501
19MP0005551_abnormal_eye_electrophysiolog2.33091998
20MP0008877_abnormal_DNA_methylation2.29001411
21MP0002184_abnormal_innervation2.25650613
22MP0004859_abnormal_synaptic_plasticity2.23016351
23MP0004043_abnormal_pH_regulation2.11741379
24MP0010386_abnormal_urinary_bladder2.08145274
25MP0005085_abnormal_gallbladder_physiolo2.00632752
26MP0010329_abnormal_lipoprotein_level1.93995717
27MP0003121_genomic_imprinting1.90486657
28MP0005360_urolithiasis1.87086065
29MP0004885_abnormal_endolymph1.85840250
30MP0005365_abnormal_bile_salt1.79732575
31MP0003646_muscle_fatigue1.77706424
32MP0002139_abnormal_hepatobiliary_system1.71979313
33MP0003329_amyloid_beta_deposits1.71274442
34MP0006292_abnormal_olfactory_placode1.69624966
35* MP0001986_abnormal_taste_sensitivity1.65704739
36MP0003122_maternal_imprinting1.63792895
37MP0001440_abnormal_grooming_behavior1.62068017
38MP0004811_abnormal_neuron_physiology1.60599716
39* MP0002067_abnormal_sensory_capabilities1.58289372
40* MP0002272_abnormal_nervous_system1.54212534
41* MP0003635_abnormal_synaptic_transmissio1.49004400
42MP0003806_abnormal_nucleotide_metabolis1.45968378
43MP0000751_myopathy1.43903188
44MP0002138_abnormal_hepatobiliary_system1.43025729
45MP0003252_abnormal_bile_duct1.41894491
46* MP0009745_abnormal_behavioral_response1.41154270
47MP0004133_heterotaxia1.37348208
48MP0004145_abnormal_muscle_electrophysio1.37244958
49MP0005645_abnormal_hypothalamus_physiol1.37123421
50MP0003123_paternal_imprinting1.34509146
51MP0005389_reproductive_system_phenotype1.34438730
52MP0001666_abnormal_nutrient_absorption1.31372055
53MP0005187_abnormal_penis_morphology1.30937218
54MP0000749_muscle_degeneration1.30323899
55MP0006072_abnormal_retinal_apoptosis1.29858791
56MP0002653_abnormal_ependyma_morphology1.26353440
57MP0004742_abnormal_vestibular_system1.26203365
58MP0005084_abnormal_gallbladder_morpholo1.23890739
59MP0002064_seizures1.23489931
60MP0002928_abnormal_bile_duct1.23391070
61MP0000372_irregular_coat_pigmentation1.22943999
62* MP0002572_abnormal_emotion/affect_behav1.22488953
63MP0005332_abnormal_amino_acid1.21870938
64MP0005083_abnormal_biliary_tract1.21833471
65MP0000631_abnormal_neuroendocrine_gland1.19576765
66MP0005253_abnormal_eye_physiology1.18560672
67* MP0000427_abnormal_hair_cycle1.18235415
68MP0002638_abnormal_pupillary_reflex1.17546208
69* MP0002063_abnormal_learning/memory/cond1.17199888
70MP0003880_abnormal_central_pattern1.15923012
71MP0001485_abnormal_pinna_reflex1.15741201
72MP0001542_abnormal_bone_strength1.11169613
73MP0009046_muscle_twitch1.11094901
74MP0000569_abnormal_digit_pigmentation1.10943394
75MP0003656_abnormal_erythrocyte_physiolo1.10331964
76MP0001919_abnormal_reproductive_system1.10087545
77MP0002160_abnormal_reproductive_system1.08402532
78MP0003119_abnormal_digestive_system1.07969245
79MP0000604_amyloidosis1.07277563
80MP0000955_abnormal_spinal_cord1.05756244
81MP0002234_abnormal_pharynx_morphology1.01750905
82MP0001984_abnormal_olfaction1.00657366
83MP0000013_abnormal_adipose_tissue1.00272082
84MP0008260_abnormal_autophagy0.99590439
85MP0003011_delayed_dark_adaptation0.98627074
86MP0002938_white_spotting0.97407184
87* MP0002882_abnormal_neuron_morphology0.97359964
88MP0003868_abnormal_feces_composition0.96281195
89MP0003136_yellow_coat_color0.94712325
90MP0005167_abnormal_blood-brain_barrier0.93751851
91MP0001270_distended_abdomen0.90910029
92MP0000778_abnormal_nervous_system0.89627972
93MP0000747_muscle_weakness0.89513987
94MP0005423_abnormal_somatic_nervous0.89426009
95MP0003890_abnormal_embryonic-extraembry0.88714675
96MP0002909_abnormal_adrenal_gland0.88698201
97MP0001324_abnormal_eye_pigmentation0.88393245
98MP0005220_abnormal_exocrine_pancreas0.87615685
99MP0001348_abnormal_lacrimal_gland0.86844200
100MP0003718_maternal_effect0.86446038
101MP0004019_abnormal_vitamin_homeostasis0.85831574
102MP0005670_abnormal_white_adipose0.85655867
103MP0001764_abnormal_homeostasis0.85578082
104MP0005647_abnormal_sex_gland0.84487245
105MP0001502_abnormal_circadian_rhythm0.84262495
106MP0001299_abnormal_eye_distance/0.83742772
107MP0002118_abnormal_lipid_homeostasis0.83673761
108MP0005195_abnormal_posterior_eye0.83382988
109MP0005535_abnormal_body_temperature0.82596676
110MP0002837_dystrophic_cardiac_calcinosis0.82312705
111MP0003633_abnormal_nervous_system0.77711865
112MP0000538_abnormal_urinary_bladder0.76878034
113MP0003634_abnormal_glial_cell0.74540694
114MP0001905_abnormal_dopamine_level0.72079788
115MP0004085_abnormal_heartbeat0.71469012
116* MP0002066_abnormal_motor_capabilities/c0.71178444
117MP0004036_abnormal_muscle_relaxation0.71109130
118MP0002229_neurodegeneration0.71058797
119MP0002972_abnormal_cardiac_muscle0.70063632
120MP0001727_abnormal_embryo_implantation0.69548711
121MP0001486_abnormal_startle_reflex0.69180681
122MP0001501_abnormal_sleep_pattern0.69010255
123MP0002752_abnormal_somatic_nervous0.68449316
124MP0000920_abnormal_myelination0.67830315
125MP0008874_decreased_physiological_sensi0.66834017
126MP0004883_abnormal_blood_vessel0.66167223
127MP0003631_nervous_system_phenotype0.64943168
128MP0000230_abnormal_systemic_arterial0.61064777
129* MP0010771_integument_phenotype0.57962752
130MP0002557_abnormal_social/conspecific_i0.57886007
131MP0000534_abnormal_ureter_morphology0.57511543
132MP0008569_lethality_at_weaning0.56278340
133MP0004130_abnormal_muscle_cell0.54812787
134MP0000343_altered_response_to0.54478825
135* MP0001756_abnormal_urination0.53645366
136MP0000759_abnormal_skeletal_muscle0.53209752
137MP0004142_abnormal_muscle_tone0.52700914
138MP0002269_muscular_atrophy0.51135283
139MP0009697_abnormal_copulation0.48194038
140MP0009780_abnormal_chondrocyte_physiolo0.46231665
141MP0003221_abnormal_cardiomyocyte_apopto0.46073164
142MP0005410_abnormal_fertilization0.45976768
143MP0001188_hyperpigmentation0.45602049
144MP0003879_abnormal_hair_cell0.43602435
145MP0005620_abnormal_muscle_contractility0.43531269
146MP0004147_increased_porphyrin_level0.42852533
147MP0003632_abnormal_nervous_system0.41721175
148MP0001963_abnormal_hearing_physiology0.40052994
149MP0004084_abnormal_cardiac_muscle0.39956436
150* MP0008872_abnormal_physiological_respon0.38962122
151MP0003183_abnormal_peptide_metabolism0.38351152
152MP0001881_abnormal_mammary_gland0.38023386
153MP0003045_fibrosis0.37643152
154MP0003172_abnormal_lysosome_physiology0.37010402
155* MP0004924_abnormal_behavior0.36140504
156* MP0005386_behavior/neurological_phenoty0.36140504
157MP0004272_abnormal_basement_membrane0.33801269
158MP0009379_abnormal_foot_pigmentation0.31924567

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)8.78821148
2Termporal pattern (HP:0011008)5.84098736
3Insidious onset (HP:0003587)5.84098736
4Myokymia (HP:0002411)5.41848837
5Hyperventilation (HP:0002883)5.28683312
6Impaired pain sensation (HP:0007328)5.13769859
7Abnormality of pain sensation (HP:0010832)5.13769859
8Pheochromocytoma (HP:0002666)4.92764040
9Dysautonomia (HP:0002459)4.83125932
10Hyporeflexia of lower limbs (HP:0002600)4.71284416
11Neuroendocrine neoplasm (HP:0100634)4.64883553
12Segmental peripheral demyelination/remyelination (HP:0003481)4.58950177
13Action tremor (HP:0002345)4.47734155
14Foot dorsiflexor weakness (HP:0009027)4.28138720
15Steppage gait (HP:0003376)4.12071969
16Pancreatic cysts (HP:0001737)3.92559535
17Autoamputation (HP:0001218)3.87837130
18Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.87430063
19Abnormality of the foot musculature (HP:0001436)3.81164530
20Distal lower limb muscle weakness (HP:0009053)3.80548497
21Protruding tongue (HP:0010808)3.76695749
22Myotonia (HP:0002486)3.75165734
23Pancreatic fibrosis (HP:0100732)3.64723619
24Abnormality of midbrain morphology (HP:0002418)3.63755478
25Molar tooth sign on MRI (HP:0002419)3.63755478
26Hammertoe (HP:0001765)3.60296428
27Nephronophthisis (HP:0000090)3.59585109
28Areflexia of lower limbs (HP:0002522)3.55219393
29True hermaphroditism (HP:0010459)3.49903397
30Ankle clonus (HP:0011448)3.48626188
31Chronic hepatic failure (HP:0100626)3.40565859
32Congenital stationary night blindness (HP:0007642)3.38607221
33Distal sensory impairment (HP:0002936)3.36553626
34Hypothermia (HP:0002045)3.35503875
35Broad-based gait (HP:0002136)3.25123543
36Clumsiness (HP:0002312)3.25001304
37Neoplasm of the peripheral nervous system (HP:0100007)3.22993800
38Abnormality of the corticospinal tract (HP:0002492)3.22538821
39Failure to thrive in infancy (HP:0001531)3.21893720
40Abnormal respiratory epithelium morphology (HP:0012253)3.16945192
41Abnormal respiratory motile cilium morphology (HP:0005938)3.16945192
42Abnormality of the renal medulla (HP:0100957)3.12357898
43Abnormality of the renal cortex (HP:0011035)3.07827939
44Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.04542151
45Onion bulb formation (HP:0003383)3.03238983
46Hypercortisolism (HP:0001578)2.96335373
47Decreased motor nerve conduction velocity (HP:0003431)2.95481108
48Urinary urgency (HP:0000012)2.94859952
49Abnormality of the vocal cords (HP:0008777)2.94028811
50Absent speech (HP:0001344)2.92987238
51Abnormal autonomic nervous system physiology (HP:0012332)2.90319649
52Type II lissencephaly (HP:0007260)2.81782498
53Thyroid carcinoma (HP:0002890)2.79751579
54Curly hair (HP:0002212)2.79551003
55Cystic liver disease (HP:0006706)2.77852598
56Drooling (HP:0002307)2.77338618
57Chronic otitis media (HP:0000389)2.72804225
58Supranuclear gaze palsy (HP:0000605)2.70041070
59Tubular atrophy (HP:0000092)2.69471013
60Hypoventilation (HP:0002791)2.67178740
61Focal seizures (HP:0007359)2.66406424
62Bradycardia (HP:0001662)2.65269563
63Fair hair (HP:0002286)2.64094040
64Abnormal drinking behavior (HP:0030082)2.62418493
65Polydipsia (HP:0001959)2.62418493
66Pendular nystagmus (HP:0012043)2.60620046
67Abolished electroretinogram (ERG) (HP:0000550)2.58847463
68Inability to walk (HP:0002540)2.56252858
69Hyperglycinuria (HP:0003108)2.56222675
70Excessive salivation (HP:0003781)2.52991958
71Arthropathy (HP:0003040)2.50207280
72Bile duct proliferation (HP:0001408)2.50055297
73Abnormal biliary tract physiology (HP:0012439)2.50055297
74Medial flaring of the eyebrow (HP:0010747)2.49170666
75Enlarged penis (HP:0000040)2.47654655
76Spastic gait (HP:0002064)2.44765062
77Axonal loss (HP:0003447)2.44251096
78Oligomenorrhea (HP:0000876)2.43985998
79Progressive cerebellar ataxia (HP:0002073)2.43641793
80Impaired proprioception (HP:0010831)2.43495788
81EMG: neuropathic changes (HP:0003445)2.42898205
82Lower limb muscle weakness (HP:0007340)2.41284722
83Aplasia/Hypoplasia of the brainstem (HP:0007362)2.36713218
84Hypoplasia of the brainstem (HP:0002365)2.36713218
85Urinary bladder sphincter dysfunction (HP:0002839)2.35294752
86Lissencephaly (HP:0001339)2.33523659
87Attenuation of retinal blood vessels (HP:0007843)2.31670686
88Cerebral hemorrhage (HP:0001342)2.30048257
89Renal cortical cysts (HP:0000803)2.27935282
90Gaze-evoked nystagmus (HP:0000640)2.22579605
91Abnormal hair whorl (HP:0010721)2.20514062
92Increased connective tissue (HP:0009025)2.20147438
93Ketosis (HP:0001946)2.19591786
94Short nail (HP:0001799)2.18015524
95Fasciculations (HP:0002380)2.17871074
96Widely spaced teeth (HP:0000687)2.16816916
97Increased CSF protein (HP:0002922)2.15786506
98Abnormality of magnesium homeostasis (HP:0004921)2.14181773
99Epileptic encephalopathy (HP:0200134)2.13199459
100Decreased central vision (HP:0007663)2.13015162
101Atonic seizures (HP:0010819)2.12780663
102Rapidly progressive (HP:0003678)2.11257486
103Progressive inability to walk (HP:0002505)2.10475931
104Keratoconus (HP:0000563)2.09819735
105Increased corneal curvature (HP:0100692)2.09819735
106Abnormal rod and cone electroretinograms (HP:0008323)2.08219574
107Hyperalaninemia (HP:0003348)2.07761419
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07761419
109Abnormality of alanine metabolism (HP:0010916)2.07761419
110Ketoacidosis (HP:0001993)2.07664171
111Polyuria (HP:0000103)2.07221239
112Abnormality of glycine metabolism (HP:0010895)2.06476826
113Abnormality of serine family amino acid metabolism (HP:0010894)2.06476826
114Chorioretinal atrophy (HP:0000533)2.06067831
115Optic nerve hypoplasia (HP:0000609)2.04984587
116Generalized hypopigmentation of hair (HP:0011358)2.04506270
117Gait imbalance (HP:0002141)2.04439783
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04301212
119Severe muscular hypotonia (HP:0006829)2.03282681
120Hemiparesis (HP:0001269)2.03061349
121Male pseudohermaphroditism (HP:0000037)2.01714544
122Morphological abnormality of the pyramidal tract (HP:0002062)2.01548058
123Tachypnea (HP:0002789)2.00873124
124Broad distal phalanx of finger (HP:0009836)1.99815550
125Muscle stiffness (HP:0003552)1.98989963
126Abnormal eating behavior (HP:0100738)1.98511555
127Disproportionate short-trunk short stature (HP:0003521)1.97982806
128Genetic anticipation (HP:0003743)1.97391417
129Febrile seizures (HP:0002373)1.97187996
130Amblyopia (HP:0000646)1.96653989
131Pachygyria (HP:0001302)1.96626354
132Slow progression (HP:0003677)1.94921117
133Congenital hepatic fibrosis (HP:0002612)1.94276313
134Stomach cancer (HP:0012126)1.93996108
135Upper limb muscle weakness (HP:0003484)1.93814705
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.93753586
137Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93753586
138Hypomagnesemia (HP:0002917)1.93551127
139Muscle fibrillation (HP:0010546)1.93504574
140Distal arthrogryposis (HP:0005684)1.93003010
141Recurrent corneal erosions (HP:0000495)1.92094790
142Peripheral demyelination (HP:0011096)1.92086476
143Sclerocornea (HP:0000647)1.90817133
144Congenital primary aphakia (HP:0007707)1.90387035
145Abnormality of calcium-phosphate metabolism (HP:0100530)1.89855208
146Cerebellar dysplasia (HP:0007033)1.89450058
147Pes cavus (HP:0001761)1.89199790
148Hand muscle atrophy (HP:0009130)1.89153757
149Hyperglycinemia (HP:0002154)1.88514234
150Decreased circulating renin level (HP:0003351)1.87361158
151Exotropia (HP:0000577)1.86986687
152Postural tremor (HP:0002174)1.86240154
153Furrowed tongue (HP:0000221)1.85654349
154Retinal dysplasia (HP:0007973)1.85394167
155Septo-optic dysplasia (HP:0100842)1.84439125
156Hypoplasia of the uterus (HP:0000013)1.84406240
157Agitation (HP:0000713)1.84395085
158Dynein arm defect of respiratory motile cilia (HP:0012255)1.83931619
159Absent/shortened dynein arms (HP:0200106)1.83931619
160Nephrogenic diabetes insipidus (HP:0009806)1.83899240
161Truncal ataxia (HP:0002078)1.82798465
162Clonus (HP:0002169)1.82699712
163Vaginal atresia (HP:0000148)1.82650024
164Abnormality of proline metabolism (HP:0010907)1.82347884
165Hydroxyprolinuria (HP:0003080)1.82347884
166Genital tract atresia (HP:0001827)1.82280728
167Abnormality of the lower motor neuron (HP:0002366)1.81906516
168Abnormal urine output (HP:0012590)1.81834809
169Dialeptic seizures (HP:0011146)1.81679594
170Paraplegia (HP:0010550)1.81117860
171Thyroid-stimulating hormone excess (HP:0002925)1.80787622
172Abnormal hemoglobin (HP:0011902)1.78973976
173Aplasia/hypoplasia of the uterus (HP:0008684)1.78517241
174Intellectual disability, severe (HP:0010864)1.77068820
175Abnormal pancreas size (HP:0012094)1.76442745
176Focal motor seizures (HP:0011153)1.75934708
177Orthostatic hypotension (HP:0001278)1.75329730
178Abnormality of macular pigmentation (HP:0008002)1.75164521
179Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74216236
180Increased variability in muscle fiber diameter (HP:0003557)1.73449131
181Delayed CNS myelination (HP:0002188)1.72748516
182Large for gestational age (HP:0001520)1.72469021
183Sudden death (HP:0001699)1.71787599
184Facial shape deformation (HP:0011334)1.71032352
185Potter facies (HP:0002009)1.71032352
186Sensory axonal neuropathy (HP:0003390)1.68408346
187Difficulty climbing stairs (HP:0003551)1.67526827
188Testicular neoplasm (HP:0010788)1.67163064
189Distal upper limb amyotrophy (HP:0007149)1.65835968
190Upper limb amyotrophy (HP:0009129)1.65835968
191Wrist flexion contracture (HP:0001239)1.65464997
192Palpitations (HP:0001962)1.65261168
193Peripheral hypomyelination (HP:0007182)1.65061084
194Aqueductal stenosis (HP:0002410)1.64323121
195Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.63768561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.12731451
2NTRK14.65071768
3MAPKAPK34.02483913
4KSR23.68706727
5MINK13.15618042
6LIMK13.02622066
7MAP3K22.85302023
8MATK2.84840264
9LMTK22.80868225
10INSRR2.71508601
11RIPK42.62755934
12NTRK32.59095847
13WNK42.53840256
14MAP3K92.53386443
15WNK32.36043162
16GRK12.35239866
17MAP3K122.26510529
18RET2.21731825
19CAMKK22.21051602
20EPHA32.17634992
21GRK52.16964994
22TAOK32.16148013
23CASK2.11207886
24ZAK2.03461593
25FER2.00905212
26ARAF1.95716562
27LATS21.93278799
28TLK11.82774935
29NUAK11.79896867
30SIK31.77679871
31ACVR1B1.71365291
32MAP2K11.68549789
33MAP4K21.68378281
34OXSR11.44156444
35AKT31.40633154
36CAMK1D1.37619789
37FGFR21.35133256
38ADRBK21.32230519
39SGK2231.31437465
40SGK4941.31437465
41SCYL21.31047781
42SIK21.30323944
43PHKG11.23410916
44PHKG21.23410916
45PIK3CA1.21520203
46MAP3K11.19945332
47MAP2K41.19420504
48PIM21.18393768
49PAK61.16713317
50CAMKK11.10596245
51RPS6KA21.09109518
52EPHB11.04585158
53BMPR1B1.04143000
54STK161.02802418
55TESK11.01458394
56STK38L1.01135165
57TNIK0.99672769
58PLK20.99549698
59MAP3K40.98500500
60MAPK130.97274937
61EPHA40.93442247
62PRKAA20.90659131
63SGK20.90319531
64ADRBK10.89445981
65MAP2K20.89382988
66PLK40.87037136
67UHMK10.84239235
68DAPK20.83678171
69CDK50.82879580
70NEK10.82009133
71CAMK1G0.81460938
72FGFR40.79914520
73DYRK20.79211250
74BCR0.78049303
75MAP2K70.77730111
76MAP3K70.74803078
77PINK10.74205324
78STK110.72341117
79RPS6KB20.71742919
80PRKD30.70745024
81NTRK20.69094331
82* PRKCE0.67944021
83CDK140.67301035
84PDK30.66488528
85PDK40.66488528
86SGK30.66052518
87MUSK0.65921244
88KSR10.65498714
89MST40.64903157
90YES10.64293928
91MYLK0.63743019
92MARK30.63349385
93PRKAA10.63171235
94DAPK10.60235574
95IRAK10.58534635
96TRIM280.58018563
97TNK20.57071780
98IKBKB0.57002700
99CAMK10.55875193
100PNCK0.54969760
101FGFR30.54366381
102MKNK20.52561255
103CHUK0.51942985
104MARK10.51372566
105MAPK150.51098052
106MAP2K60.49475488
107PTK2B0.49301621
108PRKCQ0.48364388
109PAK30.47189994
110PTK20.47178774
111TESK20.46497728
112TXK0.45959258
113DAPK30.45507387
114PRKG20.44084144
115CSNK1G10.43885255
116EPHB20.43442765
117OBSCN0.43242832
118PRKCH0.42687686
119PRKCG0.42243365
120PRKCI0.41635467
121TIE10.40950553
122STK390.39396003
123CSNK1A10.39289708
124ITK0.38981305
125CSNK1D0.38861004
126CSNK1G20.38372258
127RPS6KB10.37604940
128ROCK20.37453594
129TRPM70.37313672
130WNK10.37076988
131CAMK40.36946555
132RPS6KA60.36433850
133CSNK1G30.35667297
134PRKG10.35032554
135ERBB20.34785012
136BRAF0.34133008
137STK380.33955150
138CDK180.33531558
139STK30.33224273
140CAMK2D0.32568943
141LRRK20.31952435
142ERBB30.31570987
143AURKA0.31005111
144* PRKCA0.30582447
145TEC0.30031433
146SGK10.29995065
147PDK10.29747345
148PDPK10.27710819
149CAMK2A0.26894466
150PRPF4B0.26286694
151* SRC0.25783495
152PRKCZ0.22730384
153CSNK1A1L0.22450825
154PRKD10.22342591
155ROCK10.21906235
156* PRKACA0.21662319
157PRKCD0.21254923
158HIPK20.20637204
159CDK150.20488432

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.42460939
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.25198760
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.05703399
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.91129569
5Linoleic acid metabolism_Homo sapiens_hsa005912.88923823
6Butanoate metabolism_Homo sapiens_hsa006502.59824845
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.52382152
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36044004
9Caffeine metabolism_Homo sapiens_hsa002322.31390834
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.23685957
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.22023646
12Phototransduction_Homo sapiens_hsa047442.16941503
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14150974
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.12884108
15Thyroid cancer_Homo sapiens_hsa052162.11656435
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07269711
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05806525
18Insulin secretion_Homo sapiens_hsa049111.99363155
19Taste transduction_Homo sapiens_hsa047421.97359857
20Chemical carcinogenesis_Homo sapiens_hsa052041.87501033
21ABC transporters_Homo sapiens_hsa020101.86864666
22Nitrogen metabolism_Homo sapiens_hsa009101.85168290
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82957346
24Retinol metabolism_Homo sapiens_hsa008301.79595509
25Olfactory transduction_Homo sapiens_hsa047401.79531292
26Tryptophan metabolism_Homo sapiens_hsa003801.76547801
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.73912269
28Collecting duct acid secretion_Homo sapiens_hsa049661.63958051
29Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.60564872
30Ether lipid metabolism_Homo sapiens_hsa005651.58351246
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56200718
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55670732
33Dopaminergic synapse_Homo sapiens_hsa047281.52964516
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48798968
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.47819906
36Peroxisome_Homo sapiens_hsa041461.46366151
37Histidine metabolism_Homo sapiens_hsa003401.45259207
38Fatty acid degradation_Homo sapiens_hsa000711.44126165
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43783064
40* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.41492228
41Glioma_Homo sapiens_hsa052141.36695739
42VEGF signaling pathway_Homo sapiens_hsa043701.36184789
43Dorso-ventral axis formation_Homo sapiens_hsa043201.34658452
44Steroid biosynthesis_Homo sapiens_hsa001001.33667362
45Fat digestion and absorption_Homo sapiens_hsa049751.32702870
46Insulin signaling pathway_Homo sapiens_hsa049101.32227849
47Long-term potentiation_Homo sapiens_hsa047201.31166024
48Selenocompound metabolism_Homo sapiens_hsa004501.29242042
49Arachidonic acid metabolism_Homo sapiens_hsa005901.27564254
50Ovarian steroidogenesis_Homo sapiens_hsa049131.26712011
51Gap junction_Homo sapiens_hsa045401.25868724
52Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25799362
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.24807859
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24762682
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24126747
56Melanoma_Homo sapiens_hsa052181.23957281
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21755396
58Cholinergic synapse_Homo sapiens_hsa047251.20839170
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20800181
60Circadian entrainment_Homo sapiens_hsa047131.16166959
61Serotonergic synapse_Homo sapiens_hsa047261.16139324
62Vibrio cholerae infection_Homo sapiens_hsa051101.14836611
63Complement and coagulation cascades_Homo sapiens_hsa046101.14353777
64Renin secretion_Homo sapiens_hsa049241.14134738
65Phagosome_Homo sapiens_hsa041451.12647512
66Cyanoamino acid metabolism_Homo sapiens_hsa004601.10674515
67GnRH signaling pathway_Homo sapiens_hsa049121.10557641
68Propanoate metabolism_Homo sapiens_hsa006401.10358015
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08854740
70Endometrial cancer_Homo sapiens_hsa052131.08300280
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07388466
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05706684
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04900542
74Cardiac muscle contraction_Homo sapiens_hsa042601.04256575
75Salmonella infection_Homo sapiens_hsa051321.02927637
76SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01973192
77Prolactin signaling pathway_Homo sapiens_hsa049171.01267510
78Estrogen signaling pathway_Homo sapiens_hsa049151.00014058
79Gastric acid secretion_Homo sapiens_hsa049710.99797830
80Starch and sucrose metabolism_Homo sapiens_hsa005000.99354901
81ErbB signaling pathway_Homo sapiens_hsa040120.98474928
82Salivary secretion_Homo sapiens_hsa049700.98449158
83beta-Alanine metabolism_Homo sapiens_hsa004100.95201717
84Glutamatergic synapse_Homo sapiens_hsa047240.92381231
85Type II diabetes mellitus_Homo sapiens_hsa049300.92335018
86Long-term depression_Homo sapiens_hsa047300.91781631
87GABAergic synapse_Homo sapiens_hsa047270.91371547
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91350880
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90437444
90Endocytosis_Homo sapiens_hsa041440.90428726
91Oocyte meiosis_Homo sapiens_hsa041140.90058054
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88756431
93Arginine biosynthesis_Homo sapiens_hsa002200.88385720
94Vitamin digestion and absorption_Homo sapiens_hsa049770.87177070
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.85419912
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84747757
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84109273
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.81215086
99Fatty acid biosynthesis_Homo sapiens_hsa000610.81144210
100PPAR signaling pathway_Homo sapiens_hsa033200.81090727
101Regulation of autophagy_Homo sapiens_hsa041400.80406127
102Calcium signaling pathway_Homo sapiens_hsa040200.80344601
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79170626
104Glycerolipid metabolism_Homo sapiens_hsa005610.79159910
105Oxytocin signaling pathway_Homo sapiens_hsa049210.77347856
106Choline metabolism in cancer_Homo sapiens_hsa052310.76779673
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76187044
108Morphine addiction_Homo sapiens_hsa050320.75824457
109Basal transcription factors_Homo sapiens_hsa030220.75723002
110Bile secretion_Homo sapiens_hsa049760.75023478
111Fatty acid elongation_Homo sapiens_hsa000620.73879533
112One carbon pool by folate_Homo sapiens_hsa006700.69892339
113RNA polymerase_Homo sapiens_hsa030200.68698351
114Axon guidance_Homo sapiens_hsa043600.68129534
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.67582464
116Arginine and proline metabolism_Homo sapiens_hsa003300.66387031
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66378811
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65851223
119MAPK signaling pathway_Homo sapiens_hsa040100.65461419
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65219946
121mTOR signaling pathway_Homo sapiens_hsa041500.64792555
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64203767
123Thyroid hormone synthesis_Homo sapiens_hsa049180.62326166
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.62062156
125Circadian rhythm_Homo sapiens_hsa047100.62014581
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61997115
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.61954584
128Melanogenesis_Homo sapiens_hsa049160.61296478
129Cocaine addiction_Homo sapiens_hsa050300.61046803
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58445687
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.56006560
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55216753
133Pyruvate metabolism_Homo sapiens_hsa006200.55086834
134Prion diseases_Homo sapiens_hsa050200.53917752
135Rap1 signaling pathway_Homo sapiens_hsa040150.53800860
136Fanconi anemia pathway_Homo sapiens_hsa034600.53660187
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.52207937
138Shigellosis_Homo sapiens_hsa051310.51507936
139Non-small cell lung cancer_Homo sapiens_hsa052230.51346656
140Proteasome_Homo sapiens_hsa030500.51239302
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51109281
142Ras signaling pathway_Homo sapiens_hsa040140.50759893
143Amphetamine addiction_Homo sapiens_hsa050310.50753542
144Oxidative phosphorylation_Homo sapiens_hsa001900.49930334
145cAMP signaling pathway_Homo sapiens_hsa040240.49902471
146Metabolic pathways_Homo sapiens_hsa011000.48970589
147Nicotine addiction_Homo sapiens_hsa050330.48314521
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46212716
149Glucagon signaling pathway_Homo sapiens_hsa049220.45808020
150Amoebiasis_Homo sapiens_hsa051460.45296561
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44926793
152Sphingolipid metabolism_Homo sapiens_hsa006000.44827952
153* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44748123
154Acute myeloid leukemia_Homo sapiens_hsa052210.43188318
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43120965
156Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42305956
157Fatty acid metabolism_Homo sapiens_hsa012120.40736769
158Tyrosine metabolism_Homo sapiens_hsa003500.40516438
159Mineral absorption_Homo sapiens_hsa049780.39499467
160Parkinsons disease_Homo sapiens_hsa050120.39403650
161Intestinal immune network for IgA production_Homo sapiens_hsa046720.38179158

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