TRPV2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.55998544
2positive regulation by symbiont of host defense response (GO:0052509)5.34483492
3modulation by symbiont of host defense response (GO:0052031)5.34483492
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.34483492
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.34483492
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.34483492
7modulation by symbiont of host immune response (GO:0052553)5.34483492
8positive regulation of gamma-delta T cell activation (GO:0046645)5.20919671
9regulation of B cell receptor signaling pathway (GO:0050855)5.06414728
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.56059552
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.56059552
12antigen processing and presentation of endogenous antigen (GO:0019883)4.54209171
13neutrophil activation involved in immune response (GO:0002283)4.36659262
14response to peptidoglycan (GO:0032494)4.30130608
15regulation of interferon-beta biosynthetic process (GO:0045357)4.17294548
16immunoglobulin mediated immune response (GO:0016064)4.16937816
17leukocyte aggregation (GO:0070486)4.11268552
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.07922551
19regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.04650186
20respiratory burst (GO:0045730)4.03394738
21negative regulation of cell killing (GO:0031342)3.90308309
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.90308309
23positive regulation of antigen processing and presentation (GO:0002579)3.88886347
24positive regulation of interferon-alpha production (GO:0032727)3.88014942
25macrophage activation involved in immune response (GO:0002281)3.76543997
26detection of other organism (GO:0098543)3.74648256
27T cell migration (GO:0072678)3.73090222
28interferon-gamma production (GO:0032609)3.72459235
29regulation of interferon-alpha production (GO:0032647)3.69654796
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.67538235
31response to host immune response (GO:0052572)3.67538235
32regulation of B cell differentiation (GO:0045577)3.67395877
33positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.66983440
34detection of bacterium (GO:0016045)3.65560507
35Arp2/3 complex-mediated actin nucleation (GO:0034314)3.55014969
36cellular extravasation (GO:0045123)3.54486977
37positive regulation of B cell differentiation (GO:0045579)3.54334843
38myeloid cell activation involved in immune response (GO:0002275)3.51051664
39B cell receptor signaling pathway (GO:0050853)3.47304201
40neutrophil activation (GO:0042119)3.45667997
41mast cell activation (GO:0045576)3.44247052
42regulation of antigen processing and presentation (GO:0002577)3.41731993
43negative T cell selection (GO:0043383)3.41661041
44granulocyte activation (GO:0036230)3.41005981
45regulation of gamma-delta T cell activation (GO:0046643)3.40039237
46negative thymic T cell selection (GO:0045060)3.36779590
47negative regulation of erythrocyte differentiation (GO:0045647)3.31873032
48response to host defenses (GO:0052200)3.30799432
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30799432
50response to host (GO:0075136)3.30799432
51interferon-gamma-mediated signaling pathway (GO:0060333)3.30391217
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28866372
53microglial cell activation (GO:0001774)3.28449479
54defense response to protozoan (GO:0042832)3.28113488
55regulation of gamma-delta T cell differentiation (GO:0045586)3.25155861
56regulation of mast cell activation (GO:0033003)3.25125547
57mature B cell differentiation (GO:0002335)3.25070585
58B cell mediated immunity (GO:0019724)3.24268438
59regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.24085618
60glycosphingolipid catabolic process (GO:0046479)3.22865071
61response to muramyl dipeptide (GO:0032495)3.22762127
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.22288405
63myeloid dendritic cell activation (GO:0001773)3.21890209
64detection of external biotic stimulus (GO:0098581)3.21787002
65tolerance induction (GO:0002507)3.19962140
66type I interferon signaling pathway (GO:0060337)3.19682607
67cellular response to type I interferon (GO:0071357)3.19682607
68response to type I interferon (GO:0034340)3.18065772
69positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.17864223
70positive regulation of mast cell activation (GO:0033005)3.17375006
71negative regulation of mast cell activation (GO:0033004)3.14407706
72amino sugar catabolic process (GO:0046348)3.13562100
73pinocytosis (GO:0006907)3.10700070
74regulation of alpha-beta T cell proliferation (GO:0046640)3.08093285
75positive thymic T cell selection (GO:0045059)3.06938313
76cellular response to thyroid hormone stimulus (GO:0097067)3.06587772
77response to protozoan (GO:0001562)3.06572928
78regulation of mast cell degranulation (GO:0043304)3.05745717
79T-helper 1 type immune response (GO:0042088)3.03532582
80positive regulation of alpha-beta T cell proliferation (GO:0046641)3.00806106
81regulation of T cell tolerance induction (GO:0002664)3.00739065
82regulation of leukocyte degranulation (GO:0043300)3.00128153
83myeloid dendritic cell differentiation (GO:0043011)2.98634914
84cellular response to interleukin-15 (GO:0071350)2.97306595
85regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96790426
86detection of molecule of bacterial origin (GO:0032490)2.96254098
87regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95880400
88superoxide anion generation (GO:0042554)2.94349773
89response to interleukin-15 (GO:0070672)2.92275668
90regulation of interleukin-12 biosynthetic process (GO:0045075)2.91738523
91positive regulation of interferon-beta production (GO:0032728)2.91478734
92germinal center formation (GO:0002467)2.90670825
93actin nucleation (GO:0045010)2.90435372
94leukocyte cell-cell adhesion (GO:0007159)2.89885904
95cellular response to interferon-beta (GO:0035458)2.89746743
96regulation of interleukin-2 biosynthetic process (GO:0045076)2.89088338
97positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.88247284
98positive regulation of macrophage differentiation (GO:0045651)2.87920987
99oligosaccharide catabolic process (GO:0009313)2.87713054
100glycolipid catabolic process (GO:0019377)2.87502610
101negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.87255412
102negative regulation of phagocytosis (GO:0050765)2.86659216
103positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.86561749
104regulation of mast cell activation involved in immune response (GO:0033006)2.86356070
105leukocyte degranulation (GO:0043299)2.86203682
106NIK/NF-kappaB signaling (GO:0038061)2.85318131
107negative regulation of T cell mediated immunity (GO:0002710)2.83852989
108myeloid leukocyte activation (GO:0002274)2.83741101
109positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.82521687
110regulation of T cell receptor signaling pathway (GO:0050856)2.81348454
111lipopolysaccharide-mediated signaling pathway (GO:0031663)2.81094565
112cellular response to zinc ion (GO:0071294)2.81035555
113natural killer cell mediated cytotoxicity (GO:0042267)2.80817572
114natural killer cell mediated immunity (GO:0002228)2.80817572
115detection of biotic stimulus (GO:0009595)2.79571803
116negative regulation of innate immune response (GO:0045824)2.79428098
117negative regulation of leukocyte mediated immunity (GO:0002704)2.78473317
118negative regulation of interleukin-12 production (GO:0032695)2.77697674
119mature B cell differentiation involved in immune response (GO:0002313)2.77532692
120dendritic cell differentiation (GO:0097028)2.77166170
121positive regulation of isotype switching (GO:0045830)2.76346810
122antigen processing and presentation via MHC class Ib (GO:0002475)2.76163951
123macrophage activation (GO:0042116)2.74189048
124positive regulation of type 2 immune response (GO:0002830)2.74093445
125antigen receptor-mediated signaling pathway (GO:0050851)2.74004482
126regulation of tolerance induction (GO:0002643)2.73118585
127positive T cell selection (GO:0043368)2.72467719
128positive regulation of interferon-gamma production (GO:0032729)2.71791572
129negative regulation of lymphocyte mediated immunity (GO:0002707)2.70469269
130negative regulation of cytokine production involved in immune response (GO:0002719)2.68032515
131T cell selection (GO:0045058)2.67722512
132positive regulation of mast cell activation involved in immune response (GO:0033008)2.66464718
133positive regulation of mast cell degranulation (GO:0043306)2.66464718
134regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.65692676
135regulation of T-helper 1 cell differentiation (GO:0045625)2.63741538
136response to thyroid hormone (GO:0097066)2.62330742
137cellular response to interferon-gamma (GO:0071346)2.61297103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.02929219
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.02530801
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.36753236
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.66462315
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.38532626
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.23297006
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.98312208
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.83822694
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.66641847
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.60270716
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.37163512
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20377032
13STAT4_19710469_ChIP-ChIP_TH1__Mouse3.07632003
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.05833957
15* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.80145393
16E2F7_22180533_ChIP-Seq_HELA_Human2.73432951
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.66940531
18* SPI1_23547873_ChIP-Seq_NB4_Human2.62241328
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.54407193
20RUNX_20019798_ChIP-Seq_JUKART_Human2.47173946
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.46614213
22* MYB_26560356_Chip-Seq_TH2_Human2.43455395
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.42569007
24SCL_19346495_ChIP-Seq_HPC-7_Human2.39803584
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31397904
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.19861011
27* MAF_26560356_Chip-Seq_TH1_Human2.11408567
28* RUNX1_22412390_ChIP-Seq_EML_Mouse2.10612350
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08393883
30VDR_21846776_ChIP-Seq_THP-1_Human2.07664234
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03750839
32VDR_24763502_ChIP-Seq_THP-1_Human1.99731848
33SPI1_23127762_ChIP-Seq_K562_Human1.99539816
34* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.98859439
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98314474
36* MYB_26560356_Chip-Seq_TH1_Human1.95747609
37MYC_22102868_ChIP-Seq_BL_Human1.85417625
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.85169308
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83091801
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.75456647
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73977530
42* UTX_26944678_Chip-Seq_JUKART_Human1.72957106
43* PU_27001747_Chip-Seq_BMDM_Mouse1.69843994
44* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.68763919
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68453206
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65332811
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62889248
48LXR_22292898_ChIP-Seq_THP-1_Human1.61933519
49* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54003874
50GATA1_19941826_ChIP-Seq_K562_Human1.51843431
51GATA3_27048872_Chip-Seq_THYMUS_Human1.47915448
52* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47515433
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39405463
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.38396878
55MAF_26560356_Chip-Seq_TH2_Human1.38003003
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34740015
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.31272686
58* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30379940
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29551520
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27602220
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27132486
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26941145
63* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25918746
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22511703
65* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20613926
66* GATA3_26560356_Chip-Seq_TH2_Human1.18920017
67VDR_24787735_ChIP-Seq_THP-1_Human1.17781126
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17150871
69* NCOR1_26117541_ChIP-Seq_K562_Human1.15132392
70* TCF7_22412390_ChIP-Seq_EML_Mouse1.14732055
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.13600703
72* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12515708
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10340556
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10326038
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09643267
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09594927
77* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09265582
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.09131732
79* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07179712
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03699623
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02894178
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02159117
83GATA2_19941826_ChIP-Seq_K562_Human1.01331806
84BCOR_27268052_Chip-Seq_Bcells_Human1.00204989
85CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99632015
86KDM2B_26808549_Chip-Seq_JURKAT_Human0.97989511
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95649568
88TFEB_21752829_ChIP-Seq_HELA_Human0.95629227
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94684422
90* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93795629
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93101366
92* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91951927
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.86911866
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85567131
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85347224
96GATA1_22025678_ChIP-Seq_K562_Human0.85312177
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82452438
98SA1_27219007_Chip-Seq_ERYTHROID_Human0.82233943
99* VDR_23849224_ChIP-Seq_CD4+_Human0.80238662
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80206541
101* IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78576925
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76875174
103ELK1_19687146_ChIP-ChIP_HELA_Human0.75459464
104FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74745491
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74542904
106ELK3_25401928_ChIP-Seq_HUVEC_Human0.71865445
107SPI1_20517297_ChIP-Seq_HL60_Human0.70769697
108CIITA_25753668_ChIP-Seq_RAJI_Human0.67980602
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.67078151
110GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67053032
111SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.65746654
112KDM2B_26808549_Chip-Seq_DND41_Human0.64797634
113ETS1_22383799_ChIP-Seq_G1ME_Mouse0.63879361
114RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62891978
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.62875370
116BCL6_27268052_Chip-Seq_Bcells_Human0.61506322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.88682620
2MP0005671_abnormal_response_to3.56596320
3MP0003436_decreased_susceptibility_to3.38507402
4* MP0009785_altered_susceptibility_to3.26559977
5MP0005000_abnormal_immune_tolerance3.21178768
6MP0002148_abnormal_hypersensitivity_rea3.07446557
7MP0001800_abnormal_humoral_immune3.05014673
8MP0006082_CNS_inflammation3.04554645
9* MP0002419_abnormal_innate_immunity2.97840229
10MP0005387_immune_system_phenotype2.95991874
11MP0001790_abnormal_immune_system2.95991874
12* MP0002452_abnormal_antigen_presenting2.93513123
13* MP0005025_abnormal_response_to2.86218742
14MP0002723_abnormal_immune_serum2.79685499
15MP0003303_peritoneal_inflammation2.72642233
16* MP0001819_abnormal_immune_cell2.70671721
17* MP0002420_abnormal_adaptive_immunity2.69531786
18MP0000685_abnormal_immune_system2.68039543
19MP0004510_myositis2.45633693
20MP0005058_abnormal_lysosome_morphology2.43218074
21MP0003763_abnormal_thymus_physiology2.37369810
22MP0005464_abnormal_platelet_physiology2.34774258
23MP0003724_increased_susceptibility_to2.27891746
24MP0002398_abnormal_bone_marrow2.23655608
25MP0002405_respiratory_system_inflammati2.22072368
26MP0009333_abnormal_splenocyte_physiolog2.20674563
27MP0003172_abnormal_lysosome_physiology2.17111385
28MP0000716_abnormal_immune_system2.11684597
29MP0005174_abnormal_tail_pigmentation2.03918222
30MP0005451_abnormal_body_composition1.96044616
31MP0000689_abnormal_spleen_morphology1.86723044
32MP0001845_abnormal_inflammatory_respons1.83111062
33MP0002722_abnormal_immune_system1.76637488
34MP0002429_abnormal_blood_cell1.74683451
35MP0000015_abnormal_ear_pigmentation1.74535223
36MP0001853_heart_inflammation1.72419578
37MP0010155_abnormal_intestine_physiology1.71906154
38MP0002166_altered_tumor_susceptibility1.68807064
39MP0003183_abnormal_peptide_metabolism1.65508580
40MP0002006_tumorigenesis1.65145292
41MP0000569_abnormal_digit_pigmentation1.64739048
42MP0002396_abnormal_hematopoietic_system1.63835407
43MP0004947_skin_inflammation1.63815578
44MP0001533_abnormal_skeleton_physiology1.63062997
45MP0005310_abnormal_salivary_gland1.60324343
46MP0003448_altered_tumor_morphology1.54494951
47MP0000858_altered_metastatic_potential1.49952056
48MP0008469_abnormal_protein_level1.42758343
49MP0009764_decreased_sensitivity_to1.41491917
50MP0000703_abnormal_thymus_morphology1.36687107
51MP0001873_stomach_inflammation1.35704981
52MP0005397_hematopoietic_system_phenotyp1.35648962
53MP0001545_abnormal_hematopoietic_system1.35648962
54MP0009278_abnormal_bone_marrow1.31905550
55MP0000343_altered_response_to1.31409291
56MP0002933_joint_inflammation1.27767544
57MP0003866_abnormal_defecation1.25949528
58MP0000490_abnormal_crypts_of1.25050454
59MP0003300_gastrointestinal_ulcer1.24497722
60MP0003806_abnormal_nucleotide_metabolis1.22629948
61MP0004808_abnormal_hematopoietic_stem1.20737991
62MP0003279_aneurysm1.20372399
63MP0008260_abnormal_autophagy1.18417073
64MP0002998_abnormal_bone_remodeling1.15628775
65MP0000465_gastrointestinal_hemorrhage1.15013664
66MP0003191_abnormal_cellular_cholesterol1.07701625
67MP0002877_abnormal_melanocyte_morpholog1.06443631
68MP0010307_abnormal_tumor_latency1.02454971
69MP0002139_abnormal_hepatobiliary_system1.02311772
70MP0005075_abnormal_melanosome_morpholog1.01339772
71MP0003329_amyloid_beta_deposits0.99898949
72MP0008004_abnormal_stomach_pH0.98128771
73MP0002095_abnormal_skin_pigmentation0.96925449
74MP0003091_abnormal_cell_migration0.92987318
75MP0000372_irregular_coat_pigmentation0.92158686
76MP0006054_spinal_hemorrhage0.92043965
77MP0001986_abnormal_taste_sensitivity0.91339407
78MP0005166_decreased_susceptibility_to0.89675636
79MP0001851_eye_inflammation0.89623374
80MP0000371_diluted_coat_color0.86650219
81MP0003075_altered_response_to0.86159675
82MP0002277_abnormal_respiratory_mucosa0.83385969
83MP0002132_abnormal_respiratory_system0.80801239
84MP0008438_abnormal_cutaneous_collagen0.80667281
85MP0001958_emphysema0.79784609
86MP0000920_abnormal_myelination0.77098899
87MP0002138_abnormal_hepatobiliary_system0.75889437
88MP0005390_skeleton_phenotype0.75442390
89MP0002019_abnormal_tumor_incidence0.74062411
90MP0003656_abnormal_erythrocyte_physiolo0.73308580
91MP0003828_pulmonary_edema0.71480461
92MP0005165_increased_susceptibility_to0.70870646
93MP0003453_abnormal_keratinocyte_physiol0.70844313
94MP0004381_abnormal_hair_follicle0.67881377
95MP0001663_abnormal_digestive_system0.67021555
96MP0004782_abnormal_surfactant_physiolog0.66888684
97MP0001542_abnormal_bone_strength0.66068437
98MP0005167_abnormal_blood-brain_barrier0.66000776
99MP0005257_abnormal_intraocular_pressure0.65863176
100MP0009763_increased_sensitivity_to0.65303330
101MP0000604_amyloidosis0.60748834
102MP0008874_decreased_physiological_sensi0.59919499
103MP0000249_abnormal_blood_vessel0.59452947
104MP0010386_abnormal_urinary_bladder0.58342474
105MP0003795_abnormal_bone_structure0.57927606
106MP0005023_abnormal_wound_healing0.57841322
107MP0002735_abnormal_chemical_nociception0.57479705
108MP0003693_abnormal_embryo_hatching0.53670871
109MP0003045_fibrosis0.48939222
110MP0002136_abnormal_kidney_physiology0.46832862
111MP0005164_abnormal_response_to0.46011985
112MP0009840_abnormal_foam_cell0.45913027
113MP0003566_abnormal_cell_adhesion0.45023368
114MP0009765_abnormal_xenobiotic_induced0.44662728
115MP0008007_abnormal_cellular_replicative0.44229021
116MP0005076_abnormal_cell_differentiation0.40996127
117MP0004883_abnormal_blood_vessel0.40450581
118MP0000313_abnormal_cell_death0.40378363
119MP0003690_abnormal_glial_cell0.40325526

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.49090929
2Eczematoid dermatitis (HP:0000976)5.89024470
3Recurrent bacterial skin infections (HP:0005406)5.51019200
4Myositis (HP:0100614)4.63685247
5Elevated erythrocyte sedimentation rate (HP:0003565)4.39023266
6Recurrent fungal infections (HP:0002841)4.37629567
7Abnormality of macrophages (HP:0004311)4.32817029
8Recurrent gram-negative bacterial infections (HP:0005420)4.24997667
9Obstructive lung disease (HP:0006536)4.20457574
10Chronic obstructive pulmonary disease (HP:0006510)4.20457574
11Mediastinal lymphadenopathy (HP:0100721)4.05395871
12Vacuolated lymphocytes (HP:0001922)3.99951134
13Optic neuritis (HP:0100653)3.96738903
14Retrobulbar optic neuritis (HP:0100654)3.96738903
15Stomatitis (HP:0010280)3.89832059
16Increased cerebral lipofuscin (HP:0011813)3.89437573
17Orchitis (HP:0100796)3.86655742
18Recurrent skin infections (HP:0001581)3.81591023
19Recurrent viral infections (HP:0004429)3.77899851
20Recurrent cutaneous fungal infections (HP:0011370)3.74388140
21Chronic mucocutaneous candidiasis (HP:0002728)3.74388140
22Increased neuronal autofluorescent lipopigment (HP:0002074)3.66733700
23Meningitis (HP:0001287)3.65291678
24IgM deficiency (HP:0002850)3.57844682
25Vasculitis (HP:0002633)3.51896417
26Chronic otitis media (HP:0000389)3.48984779
27Autoimmune thrombocytopenia (HP:0001973)3.45934502
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.39791547
29Abnormality of glycolipid metabolism (HP:0010969)3.39791547
30Abnormality of liposaccharide metabolism (HP:0010968)3.39791547
31Gingivitis (HP:0000230)3.33569699
32Recurrent bronchitis (HP:0002837)3.24794022
33Cellulitis (HP:0100658)3.16689042
34Abnormality of T cell number (HP:0011839)3.03835239
35T lymphocytopenia (HP:0005403)3.01827331
36Abnormal delayed hypersensitivity skin test (HP:0002963)3.01717703
37Increased IgM level (HP:0003496)2.99492417
38Panhypogammaglobulinemia (HP:0003139)2.92278918
39Pulmonary infiltrates (HP:0002113)2.89118029
40Petechiae (HP:0000967)2.88325114
41Abnormality of T cells (HP:0002843)2.81265669
42Agammaglobulinemia (HP:0004432)2.81060869
43Leukocytosis (HP:0001974)2.75216597
44Dysostosis multiplex (HP:0000943)2.73364065
45Interstitial pulmonary disease (HP:0006530)2.73013421
46Purpura (HP:0000979)2.72586419
47Hemoptysis (HP:0002105)2.70893354
48Eosinophilia (HP:0001880)2.70830075
49Thyroiditis (HP:0100646)2.69089371
50Pustule (HP:0200039)2.66038418
51Osteomyelitis (HP:0002754)2.61570984
52Recurrent pneumonia (HP:0006532)2.58863178
53Nasal polyposis (HP:0100582)2.58262911
54Basal ganglia calcification (HP:0002135)2.58149281
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.57014529
56Inflammation of the large intestine (HP:0002037)2.55462813
57Increased serum ferritin (HP:0003281)2.52731111
58Prostate neoplasm (HP:0100787)2.52680840
59IgG deficiency (HP:0004315)2.50467826
60Lymphopenia (HP:0001888)2.48869322
61Granulocytopenia (HP:0001913)2.48761012
62Periodontitis (HP:0000704)2.48137700
63Abnormality of eosinophils (HP:0001879)2.47226700
64Hepatosplenomegaly (HP:0001433)2.45495995
65Severe combined immunodeficiency (HP:0004430)2.42571233
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.42053692
67Abnormality of T cell physiology (HP:0011840)2.42049730
68Myocardial infarction (HP:0001658)2.40536295
69Gastrointestinal infarctions (HP:0005244)2.40461143
70Prolonged bleeding time (HP:0003010)2.40368030
71Gastrointestinal inflammation (HP:0004386)2.39285478
72Hypergammaglobulinemia (HP:0010702)2.38946477
73Keratoconjunctivitis sicca (HP:0001097)2.38133065
74Systemic lupus erythematosus (HP:0002725)2.37362352
75Encephalitis (HP:0002383)2.37241456
76Spontaneous hematomas (HP:0007420)2.37223045
77Disinhibition (HP:0000734)2.35289505
78Arterial thrombosis (HP:0004420)2.34309043
79Chronic sinusitis (HP:0011109)2.33053726
80Recurrent lower respiratory tract infections (HP:0002783)2.31999551
81Abnormality of the prostate (HP:0008775)2.31381394
82Combined immunodeficiency (HP:0005387)2.29563324
83Colitis (HP:0002583)2.28146454
84Gastrointestinal stroma tumor (HP:0100723)2.24805770
85Abnormality of the nasal mucosa (HP:0000433)2.22595213
86Urticaria (HP:0001025)2.21786044
87B lymphocytopenia (HP:0010976)2.21524730
88Abnormality of B cell number (HP:0010975)2.21524730
89Autoimmune hemolytic anemia (HP:0001890)2.18800538
90Cheilitis (HP:0100825)2.18633823
91Upper motor neuron abnormality (HP:0002127)2.18491927
92Agnosia (HP:0010524)2.17858619
93Increased IgE level (HP:0003212)2.17516040
94Keratoconjunctivitis (HP:0001096)2.15205758
95Restrictive lung disease (HP:0002091)2.14987148
96Mucopolysacchariduria (HP:0008155)2.13489875
97Urinary glycosaminoglycan excretion (HP:0003541)2.13489875
98Chest pain (HP:0100749)2.12537656
99Hematochezia (HP:0002573)2.12476910
100Abnormality of iron homeostasis (HP:0011031)2.12093756
101Abnormality of polysaccharide metabolism (HP:0011012)2.11943101
102Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11943101
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11943101
104Thoracic kyphosis (HP:0002942)2.11247780
105Hypertensive crisis (HP:0100735)2.11112346
106Recurrent sinusitis (HP:0011108)2.10472325
107Lymphoma (HP:0002665)2.10094465
108Epistaxis (HP:0000421)2.09552124
109Chronic diarrhea (HP:0002028)2.09150203
110Gingival bleeding (HP:0000225)2.08614848
111Spondylolisthesis (HP:0003302)2.08612435
112Loss of speech (HP:0002371)2.06742205
113Albinism (HP:0001022)2.06706334
114Thrombocytosis (HP:0001894)2.04224241
115Premature loss of primary teeth (HP:0006323)2.03089831
116Axonal loss (HP:0003447)2.01031966
117Amyloidosis (HP:0011034)2.00469581
118Asymmetric septal hypertrophy (HP:0001670)1.91005308
119Vertebral compression fractures (HP:0002953)1.89121027
120Progressive neurologic deterioration (HP:0002344)1.87291009
121Pulmonary embolism (HP:0002204)1.86502381
122Polycythemia (HP:0001901)1.84513460
123Splenomegaly (HP:0001744)1.83066007
124Abnormality of the vasculature of the conjunctiva (HP:0008054)1.82902361
125Mutism (HP:0002300)1.81216960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.99031590
2TXK4.07911365
3IRAK43.24575405
4BLK3.13740654
5MAP3K142.95759699
6KIT2.92797350
7TBK12.89413471
8IRAK32.68638775
9RIPK42.68521229
10TYK22.59778473
11IKBKE2.46038151
12JAK32.43458378
13ZAP702.30573361
14SYK2.09382347
15IKBKB1.94535958
16BTK1.94196762
17TEC1.85985848
18CLK11.82043867
19JAK11.80228956
20TAOK21.73851369
21CSF1R1.70407239
22HCK1.61836321
23MAP3K31.59101801
24PIM21.58352527
25FES1.57574128
26ITK1.55518582
27LCK1.52594794
28LYN1.44533385
29CSK1.44438051
30MAP3K121.43792385
31NME21.41828405
32STK101.32386086
33MAP3K131.28973058
34PIM11.24680114
35TGFBR21.23987275
36TAOK31.23443676
37GRK61.22132689
38SIK31.19071413
39CDC42BPA1.11674212
40ERN11.06372554
41TAOK11.05824660
42MAP3K11.05164978
43MARK31.04446229
44FGFR31.02847210
45TRIB31.01024981
46MOS0.99946519
47CHUK0.93046160
48DDR20.91874985
49FGFR40.89380086
50GRK70.89233740
51MATK0.88336172
52SIK20.83700634
53JAK20.82678415
54MAPK70.81984945
55TNK20.81571405
56NEK90.81302263
57PIK3CG0.80200341
58NLK0.79601979
59EPHA30.78387968
60YES10.77547345
61PDPK10.77064594
62SCYL20.76815445
63TTN0.74703940
64MAPK120.74049208
65ADRBK20.72180255
66FGR0.70433367
67TRPM70.70333353
68MST40.70044363
69EPHB10.69495330
70IRAK10.68112830
71PRKD20.64547535
72RPS6KA40.63343317
73RPS6KA60.62330379
74PRKCD0.62137631
75KSR20.61877060
76MAP2K30.61835804
77ICK0.59727329
78STK240.59478818
79CDK40.58432152
80STK40.57046542
81BMPR20.55914996
82PRKCQ0.55662193
83ABL10.55059375
84LRRK20.54791995
85MAP3K80.52489587
86KDR0.51997931
87SMG10.51762475
88CDK60.50757822
89RPS6KC10.49809248
90RPS6KL10.49809248
91MAPK110.48466308
92FLT30.47459407
93EEF2K0.47278036
94MARK20.47253588
95PRKCH0.47047249
96MAPKAPK20.46961897
97EIF2AK20.45314300
98CAMKK10.45152815
99ZAK0.42153194
100SIK10.40970989
101EIF2AK30.40861146
102MAP3K110.40326353
103CAMKK20.38562172
104HIPK20.36775281
105CASK0.36231715
106PAK40.35658680
107TESK20.35216199
108ABL20.34609000
109IRAK20.34605532
110FYN0.32865706
111PTK60.32792739
112MAPK40.32694879
113RPS6KA20.31963238
114PLK40.31424294
115PRKG20.31057316
116ARAF0.31018187
117EIF2AK10.29747252
118PDK10.29491215
119VRK10.27893631
120PKN20.25788553
121MAP2K60.25348915
122DAPK10.24837260
123TLK10.24189600
124EGFR0.24062328
125PRPF4B0.22127395
126TSSK60.21822334
127SGK30.21177025
128MAP3K50.18935932

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.84902797
2Leishmaniasis_Homo sapiens_hsa051402.79873709
3Graft-versus-host disease_Homo sapiens_hsa053322.67218203
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.43804693
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35093135
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.25457946
7Measles_Homo sapiens_hsa051622.25043857
8Osteoclast differentiation_Homo sapiens_hsa043802.24289924
9Allograft rejection_Homo sapiens_hsa053302.19681888
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.17546564
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.14387551
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08434078
13Antigen processing and presentation_Homo sapiens_hsa046122.08247854
14B cell receptor signaling pathway_Homo sapiens_hsa046622.05348452
15Hematopoietic cell lineage_Homo sapiens_hsa046401.95002613
16Tuberculosis_Homo sapiens_hsa051521.89188456
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85897627
18Other glycan degradation_Homo sapiens_hsa005111.82276141
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79593161
20Lysosome_Homo sapiens_hsa041421.77542720
21Rheumatoid arthritis_Homo sapiens_hsa053231.71916652
22Legionellosis_Homo sapiens_hsa051341.71517487
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70198336
24Pertussis_Homo sapiens_hsa051331.64218422
25Staphylococcus aureus infection_Homo sapiens_hsa051501.63861081
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.63642542
27Asthma_Homo sapiens_hsa053101.63032077
28T cell receptor signaling pathway_Homo sapiens_hsa046601.61802064
29Malaria_Homo sapiens_hsa051441.55311858
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51401170
31Influenza A_Homo sapiens_hsa051641.48590607
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44350583
33Chemokine signaling pathway_Homo sapiens_hsa040621.44172050
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.43891457
35Herpes simplex infection_Homo sapiens_hsa051681.42506507
36Apoptosis_Homo sapiens_hsa042101.40237802
37Toxoplasmosis_Homo sapiens_hsa051451.37473120
38Phagosome_Homo sapiens_hsa041451.37435756
39TNF signaling pathway_Homo sapiens_hsa046681.37287268
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36205436
41Salmonella infection_Homo sapiens_hsa051321.35996503
42Shigellosis_Homo sapiens_hsa051311.33646157
43Autoimmune thyroid disease_Homo sapiens_hsa053201.32649487
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27143034
45Type I diabetes mellitus_Homo sapiens_hsa049401.24829949
46Hepatitis B_Homo sapiens_hsa051611.24613580
47Viral myocarditis_Homo sapiens_hsa054161.08156713
48Acute myeloid leukemia_Homo sapiens_hsa052211.07067681
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96821019
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94323246
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.92872511
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90697778
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88561197
54Epstein-Barr virus infection_Homo sapiens_hsa051690.88471112
55Hepatitis C_Homo sapiens_hsa051600.85070472
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80807326
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80398453
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78599484
59Pancreatic cancer_Homo sapiens_hsa052120.77095098
60African trypanosomiasis_Homo sapiens_hsa051430.76672574
61Platelet activation_Homo sapiens_hsa046110.75328023
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.74273496
63Chronic myeloid leukemia_Homo sapiens_hsa052200.70914664
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70591171
65Collecting duct acid secretion_Homo sapiens_hsa049660.70480584
66Systemic lupus erythematosus_Homo sapiens_hsa053220.64740244
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60922548
68Prolactin signaling pathway_Homo sapiens_hsa049170.60171762
69Viral carcinogenesis_Homo sapiens_hsa052030.59852409
70Base excision repair_Homo sapiens_hsa034100.59270941
71DNA replication_Homo sapiens_hsa030300.57790998
72Prion diseases_Homo sapiens_hsa050200.56365271
73Bladder cancer_Homo sapiens_hsa052190.55984024
74Homologous recombination_Homo sapiens_hsa034400.53387339
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52453803
76HTLV-I infection_Homo sapiens_hsa051660.52234418
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.49271772
78Colorectal cancer_Homo sapiens_hsa052100.48303693
79p53 signaling pathway_Homo sapiens_hsa041150.46767274
80Proteasome_Homo sapiens_hsa030500.45880766
81Complement and coagulation cascades_Homo sapiens_hsa046100.45047638
82Endocytosis_Homo sapiens_hsa041440.44975343
83Non-homologous end-joining_Homo sapiens_hsa034500.44155374
84Galactose metabolism_Homo sapiens_hsa000520.42643950
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.42180118
86VEGF signaling pathway_Homo sapiens_hsa043700.38374952
87Sphingolipid metabolism_Homo sapiens_hsa006000.37899770
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35893077
89Renal cell carcinoma_Homo sapiens_hsa052110.35753254
90Pentose phosphate pathway_Homo sapiens_hsa000300.34988443
91HIF-1 signaling pathway_Homo sapiens_hsa040660.34617502
92Fanconi anemia pathway_Homo sapiens_hsa034600.34600607
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34275323
94Ribosome_Homo sapiens_hsa030100.33597750
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33466595
96Inositol phosphate metabolism_Homo sapiens_hsa005620.32692109
97Regulation of autophagy_Homo sapiens_hsa041400.32029674
98Amoebiasis_Homo sapiens_hsa051460.30939631
99Non-small cell lung cancer_Homo sapiens_hsa052230.30915405
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29533939
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29414429
102Insulin resistance_Homo sapiens_hsa049310.28838675
103GnRH signaling pathway_Homo sapiens_hsa049120.26479217
104FoxO signaling pathway_Homo sapiens_hsa040680.25372372
105mTOR signaling pathway_Homo sapiens_hsa041500.24212629
106MAPK signaling pathway_Homo sapiens_hsa040100.23850526
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21967658
108Notch signaling pathway_Homo sapiens_hsa043300.21749251
109Vibrio cholerae infection_Homo sapiens_hsa051100.21465186
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20549995
111Small cell lung cancer_Homo sapiens_hsa052220.20338544
112Type II diabetes mellitus_Homo sapiens_hsa049300.20194506
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18829184
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.16936170
115Renin-angiotensin system_Homo sapiens_hsa046140.15851479

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