TRPV3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hair cycle (GO:0042633)8.83897872
2molting cycle (GO:0042303)8.83897872
3desmosome organization (GO:0002934)7.19130854
4axon ensheathment in central nervous system (GO:0032291)6.89571254
5central nervous system myelination (GO:0022010)6.89571254
6keratinization (GO:0031424)6.83007173
7establishment of skin barrier (GO:0061436)6.37449794
8fatty acid elongation (GO:0030497)6.32936546
9regulation of water loss via skin (GO:0033561)5.63028540
10behavioral response to nicotine (GO:0035095)5.40437059
11hemidesmosome assembly (GO:0031581)5.22926546
12long-chain fatty acid biosynthetic process (GO:0042759)5.19464346
13limb bud formation (GO:0060174)4.71479933
14intermediate filament organization (GO:0045109)4.58745553
15virion attachment to host cell (GO:0019062)4.49011158
16adhesion of symbiont to host cell (GO:0044650)4.49011158
17fucose catabolic process (GO:0019317)4.45189795
18L-fucose metabolic process (GO:0042354)4.45189795
19L-fucose catabolic process (GO:0042355)4.45189795
20DNA deamination (GO:0045006)4.33597510
21keratinocyte development (GO:0003334)4.27639637
22protein K11-linked deubiquitination (GO:0035871)4.08082389
23piRNA metabolic process (GO:0034587)4.05784442
24keratinocyte differentiation (GO:0030216)4.01527722
25indolalkylamine metabolic process (GO:0006586)4.00368660
26axon ensheathment (GO:0008366)3.89475902
27ensheathment of neurons (GO:0007272)3.89475902
28response to pheromone (GO:0019236)3.87710597
29myelination (GO:0042552)3.84095505
30multicellular organismal water homeostasis (GO:0050891)3.81233555
31negative regulation of keratinocyte proliferation (GO:0010839)3.80530647
32bundle of His cell to Purkinje myocyte communication (GO:0086069)3.77686225
33adaptation of signaling pathway (GO:0023058)3.73804010
34detection of light stimulus involved in sensory perception (GO:0050962)3.72908567
35detection of light stimulus involved in visual perception (GO:0050908)3.72908567
36epidermis development (GO:0008544)3.70975175
37peptide cross-linking (GO:0018149)3.68947699
38indole-containing compound catabolic process (GO:0042436)3.67989634
39indolalkylamine catabolic process (GO:0046218)3.67989634
40tryptophan catabolic process (GO:0006569)3.67989634
41cytidine deamination (GO:0009972)3.66483572
42cytidine metabolic process (GO:0046087)3.66483572
43cytidine catabolic process (GO:0006216)3.66483572
44lateral sprouting from an epithelium (GO:0060601)3.62161539
45presynaptic membrane organization (GO:0097090)3.61392974
46keratinocyte proliferation (GO:0043616)3.60967263
47sphingosine metabolic process (GO:0006670)3.59267913
48negative regulation of neurotransmitter secretion (GO:0046929)3.53030010
49apical protein localization (GO:0045176)3.40644119
50presynaptic membrane assembly (GO:0097105)3.37108347
51sphingoid metabolic process (GO:0046519)3.36653997
52kynurenine metabolic process (GO:0070189)3.35796675
53tryptophan metabolic process (GO:0006568)3.35411469
54cellular ketone body metabolic process (GO:0046950)3.33356575
55epidermal cell differentiation (GO:0009913)3.33007776
56adhesion of symbiont to host (GO:0044406)3.31109508
57negative regulation of neurotransmitter transport (GO:0051589)3.28407183
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27869861
59regulation of collateral sprouting (GO:0048670)3.25466054
60photoreceptor cell differentiation (GO:0046530)3.24978929
61eye photoreceptor cell differentiation (GO:0001754)3.24978929
62pyrimidine ribonucleoside catabolic process (GO:0046133)3.24931857
63diol metabolic process (GO:0034311)3.21646577
64organ growth (GO:0035265)3.18973731
65asymmetric protein localization (GO:0008105)3.12761272
66mannosylation (GO:0097502)3.12203587
67DNA methylation involved in gamete generation (GO:0043046)3.12012951
68preassembly of GPI anchor in ER membrane (GO:0016254)3.11043962
69axoneme assembly (GO:0035082)3.09401233
70ketone body metabolic process (GO:1902224)3.08100237
71indole-containing compound metabolic process (GO:0042430)3.06824063
72negative regulation of mast cell activation (GO:0033004)3.06180460
73regulation of somitogenesis (GO:0014807)3.06094349
74water homeostasis (GO:0030104)3.05757588
75cholesterol biosynthetic process (GO:0006695)3.05554182
76cornea development in camera-type eye (GO:0061303)3.05035844
77photoreceptor cell maintenance (GO:0045494)3.01486656
78regulation of glucokinase activity (GO:0033131)3.01388100
79regulation of hexokinase activity (GO:1903299)3.01388100
80negative regulation of axon extension involved in axon guidance (GO:0048843)2.99807595
81intermediate filament cytoskeleton organization (GO:0045104)2.99143231
82platelet dense granule organization (GO:0060155)2.97672895
83protein polyglutamylation (GO:0018095)2.96380822
84hair follicle morphogenesis (GO:0031069)2.95427829
85intermediate filament-based process (GO:0045103)2.94989389
86cerebral cortex radially oriented cell migration (GO:0021799)2.92799175
87respiratory chain complex IV assembly (GO:0008535)2.92409196
88long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.90722364
89drug catabolic process (GO:0042737)2.89261425
90sulfation (GO:0051923)2.88665313
91phosphatidylserine acyl-chain remodeling (GO:0036150)2.88442058
92primary amino compound metabolic process (GO:1901160)2.87402830
93glycerophospholipid catabolic process (GO:0046475)2.82848561
94exogenous drug catabolic process (GO:0042738)2.82177655
95kidney morphogenesis (GO:0060993)2.81740809
96phosphatidylinositol acyl-chain remodeling (GO:0036149)2.81469107
97regulation of transforming growth factor beta1 production (GO:0032908)2.78878344
98long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.74463671
99positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.73747849
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.71976364
101regulation of cell proliferation involved in kidney development (GO:1901722)2.71064622
102GPI anchor metabolic process (GO:0006505)2.69986631
103gamma-aminobutyric acid transport (GO:0015812)2.69979629
104L-amino acid import (GO:0043092)2.69621972
105positive regulation of hair follicle development (GO:0051798)2.68591237
106positive regulation of hair cycle (GO:0042635)2.68591237
107detection of bacterium (GO:0016045)2.67661935
108positive regulation of fatty acid transport (GO:2000193)2.67502257
109phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.65069814
110sterol biosynthetic process (GO:0016126)2.65059687
111oligodendrocyte differentiation (GO:0048709)2.64418333
112epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64269970
113transepithelial transport (GO:0070633)2.63865064
114regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.62746284
115import into cell (GO:0098657)2.62030915
116cerebellar granule cell differentiation (GO:0021707)2.60999875
117ephrin receptor signaling pathway (GO:0048013)2.60234980
118meiotic chromosome segregation (GO:0045132)2.58200362
119rRNA catabolic process (GO:0016075)2.57729170
120serotonin metabolic process (GO:0042428)2.57717285
121DNA demethylation (GO:0080111)2.57587055
122positive regulation of meiotic cell cycle (GO:0051446)2.57298027
123proline transport (GO:0015824)2.57234045
124establishment of tissue polarity (GO:0007164)2.57229718
125establishment of planar polarity (GO:0001736)2.57229718
126protein-cofactor linkage (GO:0018065)2.56522228
127amine catabolic process (GO:0009310)2.54927369
128cellular biogenic amine catabolic process (GO:0042402)2.54927369
129cytochrome complex assembly (GO:0017004)2.54751975
130water-soluble vitamin biosynthetic process (GO:0042364)2.53765105
131negative regulation of axon guidance (GO:1902668)2.51887825
132glycosphingolipid biosynthetic process (GO:0006688)2.51697465
133photoreceptor cell development (GO:0042461)2.51334865
134prostate gland growth (GO:0060736)2.51050581
135cellular response to ATP (GO:0071318)2.50784945
136male meiosis (GO:0007140)2.48792215
137negative regulation of telomere maintenance (GO:0032205)2.47692693
138regulation of rhodopsin mediated signaling pathway (GO:0022400)2.47417518
139peptidyl-histidine modification (GO:0018202)2.46437588
140positive regulation of glomerulus development (GO:0090193)2.46133030
141retinal cone cell development (GO:0046549)2.45398072
142benzene-containing compound metabolic process (GO:0042537)2.44845948
143regulation of action potential (GO:0098900)2.44215018
144Rac protein signal transduction (GO:0016601)2.44100939
145negative regulation of cell fate commitment (GO:0010454)2.43400930
146epithelial cilium movement (GO:0003351)2.42568228
147behavioral response to ethanol (GO:0048149)2.41666995
148rhodopsin mediated signaling pathway (GO:0016056)2.41421888
149regulation of chemokine secretion (GO:0090196)2.41411753
150phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.41282919
151GPI anchor biosynthetic process (GO:0006506)2.40408452
152estrogen biosynthetic process (GO:0006703)2.40404732
153negative regulation of execution phase of apoptosis (GO:1900118)2.39922346
154hair cycle process (GO:0022405)2.39648452
155molting cycle process (GO:0022404)2.39648452
156very long-chain fatty acid metabolic process (GO:0000038)2.39557911
157regulation of hippo signaling (GO:0035330)2.38573395
158glycolipid biosynthetic process (GO:0009247)2.38291267
159reflex (GO:0060004)2.37966499
160alkaloid metabolic process (GO:0009820)2.37042067
161G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.36496999
162regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.36171917
163positive regulation of icosanoid secretion (GO:0032305)2.35382551
164polyol transport (GO:0015791)2.35354056
165amyloid precursor protein metabolic process (GO:0042982)2.34965058
166negative regulation of protein localization to cell surface (GO:2000009)2.34905575
167auditory receptor cell stereocilium organization (GO:0060088)2.34540008
168multicellular organism reproduction (GO:0032504)2.34282909
169parturition (GO:0007567)2.33962359
170phosphatidylcholine acyl-chain remodeling (GO:0036151)2.33948148
171neural tube formation (GO:0001841)2.33465362
172fatty-acyl-CoA metabolic process (GO:0035337)2.32939376
173citrulline biosynthetic process (GO:0019240)2.31601117
174ectoderm development (GO:0007398)2.31125314
175cellular anion homeostasis (GO:0030002)2.29509336
176regulation of phospholipase A2 activity (GO:0032429)2.28985557
177positive regulation of interleukin-17 production (GO:0032740)2.28928527
178detection of other organism (GO:0098543)2.28304384
179negative regulation of axon extension (GO:0030517)2.27535181
180positive regulation of action potential (GO:0045760)2.27113571
181gland morphogenesis (GO:0022612)2.26137145
182positive regulation of cellular amine metabolic process (GO:0033240)2.25449736
183peptidyl-tyrosine autophosphorylation (GO:0038083)2.25018521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.75966022
2ZNF274_21170338_ChIP-Seq_K562_Hela3.88730223
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.06183267
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62779768
5GBX2_23144817_ChIP-Seq_PC3_Human2.53259438
6IGF1R_20145208_ChIP-Seq_DFB_Human2.25069864
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.10563013
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05066830
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04177866
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00734849
11EZH2_27304074_Chip-Seq_ESCs_Mouse1.97058548
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95464951
13EED_16625203_ChIP-ChIP_MESCs_Mouse1.93030435
14ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92223347
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86796688
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83733558
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83625300
18AR_21572438_ChIP-Seq_LNCaP_Human1.83527087
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78334127
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78334127
21VDR_22108803_ChIP-Seq_LS180_Human1.78294032
22BCAT_22108803_ChIP-Seq_LS180_Human1.76201315
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75885430
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75674595
25EZH2_22144423_ChIP-Seq_EOC_Human1.75642822
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73268092
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.72477898
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72259206
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71475038
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69616823
31TP53_18474530_ChIP-ChIP_U2OS_Human1.66761772
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.65485859
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.65198118
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63174143
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.62912243
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.61642141
37EWS_26573619_Chip-Seq_HEK293_Human1.58634573
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57431038
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56918036
40TAF15_26573619_Chip-Seq_HEK293_Human1.55291189
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54570210
42IRF1_19129219_ChIP-ChIP_H3396_Human1.53084846
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52219877
44CBP_20019798_ChIP-Seq_JUKART_Human1.51674056
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51674056
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51619354
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46323827
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46024615
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.45183577
50AHR_22903824_ChIP-Seq_MCF-7_Human1.43784687
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.42602640
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42602640
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.42206651
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41740267
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41496644
56* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.41285704
57NCOR_22424771_ChIP-Seq_293T_Human1.40293320
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38607760
59FOXA1_21572438_ChIP-Seq_LNCaP_Human1.38159840
60TCF4_23295773_ChIP-Seq_U87_Human1.37883012
61P300_19829295_ChIP-Seq_ESCs_Human1.37733074
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36651663
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36609179
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36238139
65RNF2_27304074_Chip-Seq_NSC_Mouse1.36021108
66TCF4_22108803_ChIP-Seq_LS180_Human1.35495788
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35363110
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.35200268
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33055203
70TP53_22573176_ChIP-Seq_HFKS_Human1.32675067
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32607085
72NANOG_19829295_ChIP-Seq_ESCs_Human1.32541088
73SOX2_19829295_ChIP-Seq_ESCs_Human1.32541088
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32271287
75REST_21632747_ChIP-Seq_MESCs_Mouse1.30564410
76TP53_16413492_ChIP-PET_HCT116_Human1.29611345
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.29298898
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28712665
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28137062
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27896931
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25143818
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24976666
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24884706
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24514361
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24125221
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24055924
87SMAD4_21799915_ChIP-Seq_A2780_Human1.23727045
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23227879
89AR_20517297_ChIP-Seq_VCAP_Human1.22836896
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22007690
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21307891
92HOXB7_26014856_ChIP-Seq_BT474_Human1.20737587
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.20435788
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.19952810
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.19334374
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19211091
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.16121108
98CDX2_22108803_ChIP-Seq_LS180_Human1.15260287
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14572732
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.14540684
101MYC_19829295_ChIP-Seq_ESCs_Human1.14275052
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13894750
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12964096
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12687878
105RUNX2_22187159_ChIP-Seq_PCA_Human1.12653299
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12605046
107FLI1_27457419_Chip-Seq_LIVER_Mouse1.12562119
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.11601688
109TP63_23658742_ChIP-Seq_EP156T_Human1.10736766
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.10250870
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.10213791
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.10113918
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09723150
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09498047
115CMYC_18555785_Chip-Seq_ESCs_Mouse1.07856433
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06766291
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.06713726
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06660940
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06418623
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06327032
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.06094384
122MYC_18940864_ChIP-ChIP_HL60_Human1.05385298
123RXR_22108803_ChIP-Seq_LS180_Human1.05362596
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05293947
125P53_22387025_ChIP-Seq_ESCs_Mouse1.03128138
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02751341
127P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01456291
128TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01293489
129GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01086133
130DROSHA_22980978_ChIP-Seq_HELA_Human1.00844914
131GABP_17652178_ChIP-ChIP_JURKAT_Human0.99710604
132HTT_18923047_ChIP-ChIP_STHdh_Human0.99636857
133FUS_26573619_Chip-Seq_HEK293_Human0.99254601
134FOXH1_21741376_ChIP-Seq_EPCs_Human0.99176917
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99014398
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99014398
137ERA_21632823_ChIP-Seq_H3396_Human0.98784583
138SOX2_20726797_ChIP-Seq_SW620_Human0.98579817
139CJUN_26792858_Chip-Seq_BT549_Human0.97609528
140GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97482416
141ER_23166858_ChIP-Seq_MCF-7_Human0.97479278
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.97443530
143GATA3_26560356_Chip-Seq_TH2_Human0.97440122
144P300_18555785_Chip-Seq_ESCs_Mouse0.97391106
145ERG_20517297_ChIP-Seq_VCAP_Human0.96599842
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96521864
147* P53_21459846_ChIP-Seq_SAOS-2_Human0.96515290
148SOX2_18555785_Chip-Seq_ESCs_Mouse0.96395888
149TBL1_22424771_ChIP-Seq_293T_Human0.95070550
150AR_25329375_ChIP-Seq_VCAP_Human0.95038944
151STAT3_18555785_Chip-Seq_ESCs_Mouse0.94601209
152STAT3_23295773_ChIP-Seq_U87_Human0.94503631
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93991308
154EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93961555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.39326117
2MP0000579_abnormal_nail_morphology5.30041017
3MP0004381_abnormal_hair_follicle4.08420575
4* MP0000383_abnormal_hair_follicle3.97315020
5* MP0010678_abnormal_skin_adnexa3.84733145
6MP0000647_abnormal_sebaceous_gland3.69567153
7* MP0002098_abnormal_vibrissa_morphology3.45937124
8MP0010234_abnormal_vibrissa_follicle3.17002374
9MP0005501_abnormal_skin_physiology3.11073443
10MP0005275_abnormal_skin_tensile3.03130761
11MP0000566_synostosis2.96654315
12MP0004043_abnormal_pH_regulation2.92585428
13MP0001346_abnormal_lacrimal_gland2.87763955
14MP0002254_reproductive_system_inflammat2.73912775
15MP0003941_abnormal_skin_development2.73647095
16MP0003136_yellow_coat_color2.68169676
17MP0008877_abnormal_DNA_methylation2.56362036
18MP0000427_abnormal_hair_cycle2.45366479
19MP0003880_abnormal_central_pattern2.44257737
20MP0000467_abnormal_esophagus_morphology2.40588739
21MP0000377_abnormal_hair_follicle2.40538750
22MP0000762_abnormal_tongue_morphology2.37862740
23* MP0001216_abnormal_epidermal_layer2.36240508
24MP0008872_abnormal_physiological_respon2.35537367
25MP0004742_abnormal_vestibular_system2.32672255
26* MP0010771_integument_phenotype2.25454977
27MP0000920_abnormal_myelination2.23136816
28MP0002060_abnormal_skin_morphology2.17731530
29MP0002876_abnormal_thyroid_physiology2.08321972
30MP0002638_abnormal_pupillary_reflex2.05067788
31MP0005451_abnormal_body_composition2.03765764
32MP0003950_abnormal_plasma_membrane1.98687955
33MP0005645_abnormal_hypothalamus_physiol1.89077583
34* MP0003453_abnormal_keratinocyte_physiol1.86825844
35MP0004270_analgesia1.64059290
36MP0003195_calcinosis1.59671256
37MP0000569_abnormal_digit_pigmentation1.58619400
38MP0005423_abnormal_somatic_nervous1.57577062
39MP0003011_delayed_dark_adaptation1.56231816
40MP0002837_dystrophic_cardiac_calcinosis1.55124223
41MP0005646_abnormal_pituitary_gland1.52540106
42MP0005171_absent_coat_pigmentation1.52154943
43MP0002138_abnormal_hepatobiliary_system1.51471919
44MP0005409_darkened_coat_color1.47715159
45* MP0004947_skin_inflammation1.45100029
46MP0001188_hyperpigmentation1.44768973
47MP0001486_abnormal_startle_reflex1.41920671
48MP0005253_abnormal_eye_physiology1.41850388
49MP0003646_muscle_fatigue1.38605162
50MP0006072_abnormal_retinal_apoptosis1.38196752
51MP0001984_abnormal_olfaction1.37255192
52MP0008875_abnormal_xenobiotic_pharmacok1.34853008
53MP0005360_urolithiasis1.34760264
54MP0002095_abnormal_skin_pigmentation1.32404250
55MP0001919_abnormal_reproductive_system1.31912390
56MP0001851_eye_inflammation1.31623592
57MP0002163_abnormal_gland_morphology1.26118815
58MP0004885_abnormal_endolymph1.20206547
59MP0002009_preneoplasia1.20129088
60MP0003787_abnormal_imprinting1.18427402
61MP0001485_abnormal_pinna_reflex1.17348208
62MP0006292_abnormal_olfactory_placode1.17234519
63MP0005174_abnormal_tail_pigmentation1.15085723
64MP0002736_abnormal_nociception_after1.15060421
65MP0000778_abnormal_nervous_system1.13754807
66MP0005075_abnormal_melanosome_morpholog1.13335002
67MP0008004_abnormal_stomach_pH1.12959464
68MP0001502_abnormal_circadian_rhythm1.11480999
69MP0005389_reproductive_system_phenotype1.11465860
70MP0008789_abnormal_olfactory_epithelium1.09860543
71MP0004145_abnormal_muscle_electrophysio1.09033277
72MP0000015_abnormal_ear_pigmentation1.07409274
73MP0006276_abnormal_autonomic_nervous1.07193200
74MP0005085_abnormal_gallbladder_physiolo1.06026407
75MP0001905_abnormal_dopamine_level1.05836553
76MP0004019_abnormal_vitamin_homeostasis1.04241948
77MP0002557_abnormal_social/conspecific_i1.02243140
78MP0001764_abnormal_homeostasis1.01696726
79MP0003252_abnormal_bile_duct1.01370444
80MP0009046_muscle_twitch0.99314645
81MP0002272_abnormal_nervous_system0.97995020
82MP0001243_abnormal_dermal_layer0.97328776
83MP0003690_abnormal_glial_cell0.97025814
84MP0005670_abnormal_white_adipose0.95840700
85MP0000631_abnormal_neuroendocrine_gland0.95417053
86MP0001529_abnormal_vocalization0.93937455
87MP0001340_abnormal_eyelid_morphology0.93822332
88* MP0000367_abnormal_coat/_hair0.93334390
89MP0001191_abnormal_skin_condition0.92988520
90MP0001440_abnormal_grooming_behavior0.91954170
91MP0002938_white_spotting0.91755519
92MP0003755_abnormal_palate_morphology0.89999706
93MP0002734_abnormal_mechanical_nocicepti0.89465896
94MP0005499_abnormal_olfactory_system0.88588098
95MP0005394_taste/olfaction_phenotype0.88588098
96* MP0009931_abnormal_skin_appearance0.88216547
97MP0004133_heterotaxia0.88153376
98MP0010386_abnormal_urinary_bladder0.88030070
99MP0002277_abnormal_respiratory_mucosa0.87991127
100MP0005332_abnormal_amino_acid0.87728362
101MP0003718_maternal_effect0.86879596
102MP0002064_seizures0.86637027
103MP0003183_abnormal_peptide_metabolism0.85626291
104MP0001765_abnormal_ion_homeostasis0.84347732
105MP0008058_abnormal_DNA_repair0.84279436
106MP0005671_abnormal_response_to0.84274269
107MP0003937_abnormal_limbs/digits/tail_de0.82735468
108MP0001177_atelectasis0.82664331
109MP0008995_early_reproductive_senescence0.82108507
110MP0008569_lethality_at_weaning0.81540046
111MP0004142_abnormal_muscle_tone0.81470023
112MP0004924_abnormal_behavior0.81186803
113MP0005386_behavior/neurological_phenoty0.81186803
114MP0004185_abnormal_adipocyte_glucose0.79643218
115MP0000685_abnormal_immune_system0.79454322
116MP0004147_increased_porphyrin_level0.78840901
117MP0010329_abnormal_lipoprotein_level0.77314594
118MP0009745_abnormal_behavioral_response0.77264917
119MP0003283_abnormal_digestive_organ0.77144193
120MP0003329_amyloid_beta_deposits0.76987826
121MP0009780_abnormal_chondrocyte_physiolo0.76537129
122MP0000230_abnormal_systemic_arterial0.76202530
123MP0002928_abnormal_bile_duct0.75385923
124MP0003938_abnormal_ear_development0.74320559
125MP0004782_abnormal_surfactant_physiolog0.73251161
126MP0000462_abnormal_digestive_system0.71875918
127MP0002572_abnormal_emotion/affect_behav0.66510151
128MP0000470_abnormal_stomach_morphology0.66093041
129MP0002234_abnormal_pharynx_morphology0.65113316
130MP0001963_abnormal_hearing_physiology0.64883963
131MP0000538_abnormal_urinary_bladder0.64862904
132MP0003385_abnormal_body_wall0.63081661
133MP0003632_abnormal_nervous_system0.62102095
134MP0005623_abnormal_meninges_morphology0.61260698
135MP0009250_abnormal_appendicular_skeleto0.60829597
136MP0005377_hearing/vestibular/ear_phenot0.60480484
137MP0003878_abnormal_ear_physiology0.60480484
138MP0002233_abnormal_nose_morphology0.58703311
139MP0003634_abnormal_glial_cell0.57897653
140MP0001986_abnormal_taste_sensitivity0.57609646
141MP0002249_abnormal_larynx_morphology0.56760846
142MP0001501_abnormal_sleep_pattern0.56634099
143MP0006082_CNS_inflammation0.56274009
144MP0005379_endocrine/exocrine_gland_phen0.53877731
145MP0002184_abnormal_innervation0.53150121
146MP0000026_abnormal_inner_ear0.53117281
147* MP0001970_abnormal_pain_threshold0.51986497
148MP0002102_abnormal_ear_morphology0.51743984
149MP0003635_abnormal_synaptic_transmissio0.51496426
150MP0001968_abnormal_touch/_nociception0.51395598
151MP0005551_abnormal_eye_electrophysiolog0.51326871
152MP0000613_abnormal_salivary_gland0.51277508
153MP0000372_irregular_coat_pigmentation0.51275374
154MP0004264_abnormal_extraembryonic_tissu0.51013248
155MP0002735_abnormal_chemical_nociception0.50733199
156MP0002177_abnormal_outer_ear0.49543082
157MP0002229_neurodegeneration0.49385861
158MP0008260_abnormal_autophagy0.48572485
159MP0009384_cardiac_valve_regurgitation0.47624726
160MP0001299_abnormal_eye_distance/0.47144931

Predicted human phenotypes

RankGene SetZ-score
1* Parakeratosis (HP:0001036)7.00593303
2Hypotrichosis (HP:0001006)5.95944803
3Plantar hyperkeratosis (HP:0007556)5.12709841
4Onycholysis (HP:0001806)4.95266643
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.94735853
6Congenital ichthyosiform erythroderma (HP:0007431)4.94025997
7Fragile nails (HP:0001808)4.88820745
8Woolly hair (HP:0002224)4.71287314
9Erythroderma (HP:0001019)4.67938638
10Abnormality of nail color (HP:0100643)4.59629052
11Palmoplantar hyperkeratosis (HP:0000972)4.56312668
12Thick nail (HP:0001805)4.40098014
13Palmar hyperkeratosis (HP:0010765)4.34412751
14Pili torti (HP:0003777)4.19516650
15Milia (HP:0001056)3.96864947
16Brittle hair (HP:0002299)3.76600091
17Alopecia of scalp (HP:0002293)3.71787036
18Pancreatic cysts (HP:0001737)3.68583225
19Congenital stationary night blindness (HP:0007642)3.65976129
20Follicular hyperkeratosis (HP:0007502)3.65622332
21Increased IgE level (HP:0003212)3.61386430
22Right ventricular cardiomyopathy (HP:0011663)3.40123635
23* Nail dystrophy (HP:0008404)3.31649110
24Ectropion (HP:0000656)3.30109494
25Corneal erosion (HP:0200020)3.22765001
26Recurrent corneal erosions (HP:0000495)3.19672950
27Pancreatic fibrosis (HP:0100732)3.17852899
28Abnormality of midbrain morphology (HP:0002418)3.15920733
29Molar tooth sign on MRI (HP:0002419)3.15920733
30Decreased circulating renin level (HP:0003351)3.08317008
31Erythema (HP:0010783)3.02803116
32True hermaphroditism (HP:0010459)3.02290119
33Abnormality of the renal cortex (HP:0011035)3.01840756
34* Hypohidrosis (HP:0000966)2.95613261
35Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.93529623
36Lip pit (HP:0100267)2.92402588
37Nephronophthisis (HP:0000090)2.90569876
38Aplasia cutis congenita (HP:0001057)2.89084717
39Concave nail (HP:0001598)2.86717076
40Type II lissencephaly (HP:0007260)2.84848144
41Furrowed tongue (HP:0000221)2.80621386
42Abnormality of the renal medulla (HP:0100957)2.71482201
43Tubular atrophy (HP:0000092)2.69206753
44Sensory axonal neuropathy (HP:0003390)2.69037173
45Conical tooth (HP:0000698)2.67013700
46Amelogenesis imperfecta (HP:0000705)2.61622647
47Absent eyebrow (HP:0002223)2.61491996
48Hyperventilation (HP:0002883)2.59714687
49Neurofibrillary tangles (HP:0002185)2.57885306
50Attenuation of retinal blood vessels (HP:0007843)2.57651064
51Abnormal rod and cone electroretinograms (HP:0008323)2.57057364
52Chronic hepatic failure (HP:0100626)2.55361936
53Slow-growing hair (HP:0002217)2.54749641
54Abnormality of hair growth rate (HP:0011363)2.54749641
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.54164822
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54164822
57Abnormal hair laboratory examination (HP:0003328)2.52518755
58Gangrene (HP:0100758)2.48251357
59Ridged nail (HP:0001807)2.44562240
60Medial flaring of the eyebrow (HP:0010747)2.42632828
61White forelock (HP:0002211)2.42247575
62Premature skin wrinkling (HP:0100678)2.41300709
63Sparse eyelashes (HP:0000653)2.40449509
64Thickened helices (HP:0000391)2.37552479
65Natal tooth (HP:0000695)2.37443184
66Abnormal blistering of the skin (HP:0008066)2.32829087
67Septo-optic dysplasia (HP:0100842)2.31746976
68Congenital sensorineural hearing impairment (HP:0008527)2.31587826
69Abolished electroretinogram (ERG) (HP:0000550)2.31454378
70Polydipsia (HP:0001959)2.30407131
71Abnormal drinking behavior (HP:0030082)2.30407131
72Cupped ear (HP:0000378)2.27410264
73Esophageal atresia (HP:0002032)2.27263858
74Absent septum pellucidum (HP:0001331)2.25812875
75Cerebellar dysplasia (HP:0007033)2.24178337
76Hypomagnesemia (HP:0002917)2.18550475
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18284099
78Alacrima (HP:0000522)2.18102726
79Patchy hypopigmentation of hair (HP:0011365)2.16774101
80Corneal dystrophy (HP:0001131)2.15065324
81Abnormality of the axillary hair (HP:0100134)2.14971050
82Abnormality of secondary sexual hair (HP:0009888)2.14971050
83Hypokalemic alkalosis (HP:0001949)2.13712529
84Stenosis of the external auditory canal (HP:0000402)2.12702052
85Renal cortical cysts (HP:0000803)2.11910714
86Absent eyelashes (HP:0000561)2.10874465
87Abnormality of alanine metabolism (HP:0010916)2.10870524
88Hyperalaninemia (HP:0003348)2.10870524
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10870524
90Oral leukoplakia (HP:0002745)2.08974889
91Inability to walk (HP:0002540)2.08765131
92Aplasia/Hypoplasia of the spleen (HP:0010451)2.08434192
93* Pruritus (HP:0000989)2.08231674
94Aplasia involving bones of the extremities (HP:0009825)2.08115641
95Aplasia involving bones of the upper limbs (HP:0009823)2.08115641
96Aplasia of the phalanges of the hand (HP:0009802)2.08115641
97Lissencephaly (HP:0001339)2.06583157
98Duplicated collecting system (HP:0000081)2.04599340
99Abnormality of molar morphology (HP:0011070)2.04361042
100Abnormality of molar (HP:0011077)2.04361042
101Cystic liver disease (HP:0006706)2.03126549
102Abnormality of the dental root (HP:0006486)2.02525628
103Taurodontia (HP:0000679)2.02525628
104Abnormality of permanent molar morphology (HP:0011071)2.02525628
105Abnormality of renin-angiotensin system (HP:0000847)2.01465240
106Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99363588
107Peripheral hypomyelination (HP:0007182)1.99260503
108Dynein arm defect of respiratory motile cilia (HP:0012255)1.98580131
109Absent/shortened dynein arms (HP:0200106)1.98580131
110Gaze-evoked nystagmus (HP:0000640)1.98578452
111Abnormal ciliary motility (HP:0012262)1.97800208
112Asplenia (HP:0001746)1.97401793
113Aplasia/hypoplasia of the uterus (HP:0008684)1.95661098
114Hyporeflexia of lower limbs (HP:0002600)1.95537495
115Xerostomia (HP:0000217)1.93483500
116Hypoplasia of the uterus (HP:0000013)1.93147865
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92892452
118Aplasia/Hypoplasia of the tibia (HP:0005772)1.92813799
119Pendular nystagmus (HP:0012043)1.92012396
120Absent hair (HP:0002298)1.91422423
121Abnormality of incisor morphology (HP:0011063)1.91007485
122Split foot (HP:0001839)1.90580527
123Sclerocornea (HP:0000647)1.90325260
124Metabolic alkalosis (HP:0200114)1.89956962
125Atrophic scars (HP:0001075)1.89576713
126Nasolacrimal duct obstruction (HP:0000579)1.88806504
127Hypoplastic labia majora (HP:0000059)1.88585197
128Fair hair (HP:0002286)1.88406302
129Chorioretinal atrophy (HP:0000533)1.88375164
130Abnormality of the renal collecting system (HP:0004742)1.87375902
131Bile duct proliferation (HP:0001408)1.87311418
132Abnormal biliary tract physiology (HP:0012439)1.87311418
133Intention tremor (HP:0002080)1.87292247
134Bony spicule pigmentary retinopathy (HP:0007737)1.86090892
135Gait imbalance (HP:0002141)1.85768701
136* Palmoplantar keratoderma (HP:0000982)1.85702615
137Onion bulb formation (HP:0003383)1.84107334
138Segmental peripheral demyelination/remyelination (HP:0003481)1.83575427
139Limb dystonia (HP:0002451)1.83423755
140IgG deficiency (HP:0004315)1.83342587
141Advanced eruption of teeth (HP:0006288)1.83081027
142Polyuria (HP:0000103)1.82626061
143Abnormality of the phalanges of the 2nd finger (HP:0009541)1.82467741
144Stomach cancer (HP:0012126)1.82130746
145Severe Myopia (HP:0011003)1.80446032
146Abnormality of the septum pellucidum (HP:0007375)1.79882014
147Abnormal respiratory motile cilium physiology (HP:0012261)1.79532811
148Congenital, generalized hypertrichosis (HP:0004540)1.79240623
149Abnormality of the parietal bone (HP:0002696)1.78552711
150Abnormality of dental color (HP:0011073)1.77825702
151Abnormality of the labia majora (HP:0012881)1.77035088
152Febrile seizures (HP:0002373)1.76959909
153Congenital primary aphakia (HP:0007707)1.76411640
154Hypoplastic pelvis (HP:0008839)1.76005067
155Hyperglycinuria (HP:0003108)1.75424288
156Type 2 muscle fiber atrophy (HP:0003554)1.73868466
157Progressive inability to walk (HP:0002505)1.73288427
158Fine hair (HP:0002213)1.72936260
159Hypophosphatemic rickets (HP:0004912)1.72053174
160Congenital hepatic fibrosis (HP:0002612)1.71386359
161Decreased central vision (HP:0007663)1.70564340
162Increased CSF lactate (HP:0002490)1.70511881
163Broad-based gait (HP:0002136)1.70467882
1643-Methylglutaconic aciduria (HP:0003535)1.70405008
165Widely spaced teeth (HP:0000687)1.69876681
166Progressive cerebellar ataxia (HP:0002073)1.69839785
167Abnormality of the dental pulp (HP:0006479)1.69788310
168Abnormality of magnesium homeostasis (HP:0004921)1.69189046
169Alkalosis (HP:0001948)1.69040392
170Methylmalonic aciduria (HP:0012120)1.68777602
171Anencephaly (HP:0002323)1.68443838
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.68222928
173Keratoconus (HP:0000563)1.65759942
174Increased corneal curvature (HP:0100692)1.65759942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.66210560
2CASK3.91188903
3OXSR13.77749335
4STK393.31177890
5ACVR1B3.16170707
6MAP4K23.02417754
7TAOK32.85759928
8CDK192.79185508
9MST42.78928386
10BCR2.74126131
11EPHB12.61875681
12BMPR1B2.57948838
13PINK12.50429608
14FGFR22.48694592
15ZAK2.40270346
16PKN12.36483143
17MST1R2.26988206
18MAP3K132.21737697
19WNK32.10785717
20EPHA42.00893407
21MET1.92382437
22EPHA21.84745472
23MAPKAPK51.75802681
24LATS11.67248049
25PBK1.65663422
26SIK31.53413227
27DAPK21.46983549
28FER1.45765653
29MARK21.45357748
30TLK11.44662086
31NTRK21.38965345
32MAP3K141.38586902
33FGR1.34191066
34TRPM71.33715277
35TRIM281.31559447
36CLK11.30866287
37ADRBK21.29770616
38NEK61.28580958
39MARK11.12242510
40TGFBR11.11024803
41ADRBK11.10494897
42MAP2K71.08192451
43SGK2231.06856349
44SGK4941.06856349
45MAP3K21.05661573
46BMPR21.04155141
47TNK21.03705666
48CAMK2B1.02640963
49MKNK21.01427700
50PRKCG0.99255352
51DYRK20.98634649
52PRPF4B0.98606539
53IKBKB0.98444221
54WNK10.98279373
55BRSK20.98078403
56MAPKAPK30.93835305
57TAF10.93383217
58ROCK20.92644308
59SIK10.92536374
60MAP3K40.90009147
61PRKCE0.89303671
62MAPK150.89148732
63CAMK2A0.88374284
64CDK30.87796851
65CCNB10.85678393
66PIK3CA0.82654353
67STK160.81417235
68NTRK30.80927973
69WEE10.80881640
70MAP3K120.80753757
71EIF2AK30.80525201
72VRK10.78737510
73TNIK0.78048260
74ERBB40.77967810
75PRKCI0.77333933
76PRKCQ0.76982144
77GRK70.75815442
78LIMK10.74435429
79NME10.72870786
80BCKDK0.70662999
81AKT30.70585269
82TIE10.69619171
83CSNK1A1L0.69115072
84MUSK0.68242210
85MAP3K60.66963261
86IKBKE0.66485944
87WNK40.66399696
88STK30.63862036
89FGFR10.62451999
90MAP3K70.60298937
91CAMK2G0.59175437
92CAMK2D0.58147586
93INSRR0.57072602
94MAP2K20.56800637
95NUAK10.55378754
96PNCK0.55368532
97PRKG10.55259849
98MAP4K10.54609658
99MOS0.54580474
100BRAF0.53527108
101IRAK40.51126182
102MAP2K10.50470827
103PRKCH0.49374127
104CHUK0.49300300
105CDK50.49087087
106OBSCN0.48451762
107EPHB20.47784501
108SGK20.46670641
109PIK3CG0.46368557
110RPS6KA50.46011495
111ARAF0.45283171
112ITK0.45238454
113PRKCZ0.44771761
114CSNK1G30.43354982
115UHMK10.42735083
116CSNK1D0.42635115
117SGK10.42172309
118PRKAA20.41936818
119FYN0.41935188
120PLK20.41692958
121DYRK1A0.41499167
122MAP3K30.40420832
123CSNK1G20.39764029
124CAMKK20.38725956
125MAP2K60.38571169
126STK38L0.38499387
127GRK10.38462509
128MAP3K90.38313935
129CSNK1G10.38024339
130TEC0.36912044
131PIM10.36463023
132CSNK1A10.36460446
133DYRK30.36169991
134PHKG10.35844194
135PHKG20.35844194
136EIF2AK20.35110959
137MAPK130.35060692
138SIK20.34925397
139PRKD10.34902213
140DDR20.34714708
141PTK2B0.34528473
142PRKACA0.34500051
143TXK0.34326431
144ABL10.32959153
145PAK30.32602639
146PRKCA0.32450673
147GRK50.32315599
148STK240.32113743
149IRAK10.30251206
150FLT30.29368713

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.60673298
2Steroid biosynthesis_Homo sapiens_hsa001003.51102203
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.50798276
4Ether lipid metabolism_Homo sapiens_hsa005653.09366261
5Sphingolipid metabolism_Homo sapiens_hsa006003.02854116
6Linoleic acid metabolism_Homo sapiens_hsa005912.81010648
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.71568476
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.58248425
9Caffeine metabolism_Homo sapiens_hsa002322.47009881
10Butanoate metabolism_Homo sapiens_hsa006502.26296362
11Axon guidance_Homo sapiens_hsa043602.13661765
12Nitrogen metabolism_Homo sapiens_hsa009102.10327090
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10303563
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.00792826
15Tryptophan metabolism_Homo sapiens_hsa003801.91788158
16Arachidonic acid metabolism_Homo sapiens_hsa005901.87869689
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.82150027
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66367483
19Histidine metabolism_Homo sapiens_hsa003401.63288356
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63139353
21Mineral absorption_Homo sapiens_hsa049781.62342334
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.55823221
23Oxidative phosphorylation_Homo sapiens_hsa001901.50791052
24Serotonergic synapse_Homo sapiens_hsa047261.46636920
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43069204
26Primary immunodeficiency_Homo sapiens_hsa053401.40293951
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33643105
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32849406
29Nicotine addiction_Homo sapiens_hsa050331.29741571
30Long-term depression_Homo sapiens_hsa047301.27351466
31Basal transcription factors_Homo sapiens_hsa030221.26263678
32Ovarian steroidogenesis_Homo sapiens_hsa049131.26103008
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24167710
34Fanconi anemia pathway_Homo sapiens_hsa034601.22624295
35Homologous recombination_Homo sapiens_hsa034401.22592096
36Rheumatoid arthritis_Homo sapiens_hsa053231.20461939
37Basal cell carcinoma_Homo sapiens_hsa052171.20439842
38Hedgehog signaling pathway_Homo sapiens_hsa043401.19078297
39Propanoate metabolism_Homo sapiens_hsa006401.18757917
40Chemical carcinogenesis_Homo sapiens_hsa052041.17223924
41Sulfur metabolism_Homo sapiens_hsa009201.15357841
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14342351
43Protein export_Homo sapiens_hsa030601.14327316
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12064152
45Parkinsons disease_Homo sapiens_hsa050121.10530830
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09755645
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.09380072
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09278700
49Selenocompound metabolism_Homo sapiens_hsa004501.07044173
50Glutamatergic synapse_Homo sapiens_hsa047241.06018299
51Collecting duct acid secretion_Homo sapiens_hsa049661.05967094
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04761528
53Dorso-ventral axis formation_Homo sapiens_hsa043201.03117529
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02222331
55Taste transduction_Homo sapiens_hsa047421.00283679
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97408630
57Tight junction_Homo sapiens_hsa045300.96325290
58Insulin secretion_Homo sapiens_hsa049110.96267372
59Morphine addiction_Homo sapiens_hsa050320.95478247
60Autoimmune thyroid disease_Homo sapiens_hsa053200.95137469
61Peroxisome_Homo sapiens_hsa041460.93590340
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.93149923
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92609362
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.92314126
65Fatty acid biosynthesis_Homo sapiens_hsa000610.91837350
66Glycerolipid metabolism_Homo sapiens_hsa005610.91718041
67Ras signaling pathway_Homo sapiens_hsa040140.90501508
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.89480346
69Graft-versus-host disease_Homo sapiens_hsa053320.88850631
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87960787
71beta-Alanine metabolism_Homo sapiens_hsa004100.85409965
72ECM-receptor interaction_Homo sapiens_hsa045120.84346360
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81939880
74Phototransduction_Homo sapiens_hsa047440.81665447
75Regulation of autophagy_Homo sapiens_hsa041400.81197796
76RNA polymerase_Homo sapiens_hsa030200.80454607
77Malaria_Homo sapiens_hsa051440.79894460
78Hippo signaling pathway_Homo sapiens_hsa043900.78899022
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.78089240
80Salmonella infection_Homo sapiens_hsa051320.78009034
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77734049
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75954485
83RNA degradation_Homo sapiens_hsa030180.75051625
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72818832
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71081648
86African trypanosomiasis_Homo sapiens_hsa051430.69925563
87Salivary secretion_Homo sapiens_hsa049700.68494354
88Vitamin digestion and absorption_Homo sapiens_hsa049770.68412180
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67926979
90GABAergic synapse_Homo sapiens_hsa047270.67420981
91Type I diabetes mellitus_Homo sapiens_hsa049400.66524118
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66471649
93Calcium signaling pathway_Homo sapiens_hsa040200.64767055
94Allograft rejection_Homo sapiens_hsa053300.63348060
95ErbB signaling pathway_Homo sapiens_hsa040120.63106016
96Wnt signaling pathway_Homo sapiens_hsa043100.62819304
97Choline metabolism in cancer_Homo sapiens_hsa052310.61356084
98Circadian entrainment_Homo sapiens_hsa047130.60373737
99Melanogenesis_Homo sapiens_hsa049160.60281540
100* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58700270
101Pancreatic secretion_Homo sapiens_hsa049720.58020847
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57861236
103Pertussis_Homo sapiens_hsa051330.57732103
104Retinol metabolism_Homo sapiens_hsa008300.57209149
105Cardiac muscle contraction_Homo sapiens_hsa042600.57203367
106Renin secretion_Homo sapiens_hsa049240.57113154
107Circadian rhythm_Homo sapiens_hsa047100.56368767
108Other glycan degradation_Homo sapiens_hsa005110.56203474
109Metabolic pathways_Homo sapiens_hsa011000.56054595
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56039413
111Alzheimers disease_Homo sapiens_hsa050100.55931663
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55488456
113Protein digestion and absorption_Homo sapiens_hsa049740.55237510
114Renal cell carcinoma_Homo sapiens_hsa052110.54934448
115Vibrio cholerae infection_Homo sapiens_hsa051100.53419719
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51751409
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51125252
118Huntingtons disease_Homo sapiens_hsa050160.49779299
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.48155829
120cAMP signaling pathway_Homo sapiens_hsa040240.47715244
121Amphetamine addiction_Homo sapiens_hsa050310.46751130
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46479831
123Dopaminergic synapse_Homo sapiens_hsa047280.45912825
124Phagosome_Homo sapiens_hsa041450.45265047
125Asthma_Homo sapiens_hsa053100.45153609
126Synaptic vesicle cycle_Homo sapiens_hsa047210.43736633
127TGF-beta signaling pathway_Homo sapiens_hsa043500.43538749
128MAPK signaling pathway_Homo sapiens_hsa040100.43207915
129Arginine and proline metabolism_Homo sapiens_hsa003300.42768284
130Rap1 signaling pathway_Homo sapiens_hsa040150.40898075
131GnRH signaling pathway_Homo sapiens_hsa049120.40748727
132Fat digestion and absorption_Homo sapiens_hsa049750.40392013
133Hematopoietic cell lineage_Homo sapiens_hsa046400.39050518
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38983048
135Cocaine addiction_Homo sapiens_hsa050300.38127493
136Bile secretion_Homo sapiens_hsa049760.37356130
137Olfactory transduction_Homo sapiens_hsa047400.37010119
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36894378
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36711887
140Hepatitis C_Homo sapiens_hsa051600.36590817
141ABC transporters_Homo sapiens_hsa020100.36460925
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35148380
143Purine metabolism_Homo sapiens_hsa002300.34683770
144One carbon pool by folate_Homo sapiens_hsa006700.34581411
145Fatty acid degradation_Homo sapiens_hsa000710.34515607
146Gastric acid secretion_Homo sapiens_hsa049710.32907322
147p53 signaling pathway_Homo sapiens_hsa041150.32610538
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32498739
149Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32007692

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