TRPV4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.78422032
2motile cilium assembly (GO:0044458)7.96464100
3cilium movement (GO:0003341)7.73734013
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.57778421
5keratan sulfate catabolic process (GO:0042340)6.56664725
6epithelial cilium movement (GO:0003351)6.18787472
7aminoglycoside antibiotic metabolic process (GO:0030647)6.16748146
8urate metabolic process (GO:0046415)6.12071326
9cartilage development involved in endochondral bone morphogenesis (GO:0060351)6.04910965
10drug transmembrane transport (GO:0006855)5.90745742
11organic cation transport (GO:0015695)5.75813725
12primary alcohol catabolic process (GO:0034310)5.33281567
13drug transport (GO:0015893)5.19931789
14left/right pattern formation (GO:0060972)5.19083222
15cell aggregation (GO:0098743)4.94347122
16cartilage condensation (GO:0001502)4.94347122
17ethanol metabolic process (GO:0006067)4.84964537
18axoneme assembly (GO:0035082)4.81424386
19phosphate ion transport (GO:0006817)4.71800491
20renal absorption (GO:0070293)4.69360696
21chondrocyte development (GO:0002063)4.68295552
22vitamin transmembrane transport (GO:0035461)4.66717155
23excretion (GO:0007588)4.65455491
24diterpenoid biosynthetic process (GO:0016102)4.63752110
25iron ion import (GO:0097286)4.39310258
26metanephric tubule development (GO:0072170)4.27822137
27metanephric nephron tubule development (GO:0072234)4.27822137
28metanephric nephron epithelium development (GO:0072243)4.20731336
29positive regulation of extracellular matrix organization (GO:1903055)4.20250508
30lung epithelium development (GO:0060428)4.19197340
31lysine catabolic process (GO:0006554)4.18749220
32lysine metabolic process (GO:0006553)4.18749220
33quaternary ammonium group transport (GO:0015697)4.15915388
34cellular response to vitamin D (GO:0071305)4.15063400
35collagen fibril organization (GO:0030199)4.13267001
36negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.11546442
37toxin transport (GO:1901998)4.00879324
38ethanol oxidation (GO:0006069)4.00042531
39response to mercury ion (GO:0046689)3.97088351
40notochord development (GO:0030903)3.91875681
41regulation of apoptotic cell clearance (GO:2000425)3.85493759
42vitamin D metabolic process (GO:0042359)3.84642060
43establishment of apical/basal cell polarity (GO:0035089)3.84451794
44metanephric epithelium development (GO:0072207)3.83453468
45phosphate ion transmembrane transport (GO:0035435)3.80392993
46regulation of apoptotic process involved in morphogenesis (GO:1902337)3.79811788
47pyrimidine-containing compound transmembrane transport (GO:0072531)3.75898133
48negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.75802953
49response to magnesium ion (GO:0032026)3.75782431
50nephron tubule formation (GO:0072079)3.72251697
51nephron tubule development (GO:0072080)3.71922004
52negative regulation of humoral immune response (GO:0002921)3.71830091
53peptidyl-glutamic acid carboxylation (GO:0017187)3.67027103
54protein carboxylation (GO:0018214)3.67027103
55response to vitamin D (GO:0033280)3.63530857
56dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.59602185
57oligosaccharide catabolic process (GO:0009313)3.59381532
58fibrinolysis (GO:0042730)3.58309881
59cellular response to vitamin (GO:0071295)3.52399151
60glomerular epithelial cell development (GO:0072310)3.51982816
61trivalent inorganic anion homeostasis (GO:0072506)3.51010062
62phosphate ion homeostasis (GO:0055062)3.51010062
63limb bud formation (GO:0060174)3.50502892
64collagen catabolic process (GO:0030574)3.49795585
65left/right axis specification (GO:0070986)3.46302563
66response to xenobiotic stimulus (GO:0009410)3.43367716
67collagen metabolic process (GO:0032963)3.42854326
68endothelial cell morphogenesis (GO:0001886)3.42637102
69exogenous drug catabolic process (GO:0042738)3.41786720
70cysteine metabolic process (GO:0006534)3.37536773
71regulation of extracellular matrix disassembly (GO:0010715)3.32650837
72hemidesmosome assembly (GO:0031581)3.31378153
73glucuronate metabolic process (GO:0019585)3.30747091
74uronic acid metabolic process (GO:0006063)3.30747091
75planar cell polarity pathway involved in neural tube closure (GO:0090179)3.29953481
76glycoside metabolic process (GO:0016137)3.29447446
77negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.28317233
78microtubule bundle formation (GO:0001578)3.27789420
79polyol transport (GO:0015791)3.27324313
80nonribosomal peptide biosynthetic process (GO:0019184)3.26908227
81ventricular system development (GO:0021591)3.25824337
82cartilage development (GO:0051216)3.25608353
83multicellular organismal catabolic process (GO:0044243)3.25502210
84multicellular organismal macromolecule metabolic process (GO:0044259)3.24009557
85nephron epithelium development (GO:0072009)3.21023712
86sodium-independent organic anion transport (GO:0043252)3.20548795
87drug catabolic process (GO:0042737)3.19951246
88regulation of cilium movement (GO:0003352)3.18256615
89renal tubule development (GO:0061326)3.18077200
90modified amino acid transport (GO:0072337)3.15951391
91apoptotic cell clearance (GO:0043277)3.14782970
92negative regulation of fibrinolysis (GO:0051918)3.14679133
93peptide catabolic process (GO:0043171)3.14427282
94multicellular organismal metabolic process (GO:0044236)3.13764599
95cellular glucuronidation (GO:0052695)3.13312213
96chondrocyte differentiation (GO:0002062)3.12854319
97regulation of protein activation cascade (GO:2000257)3.11050712
98cell-cell junction maintenance (GO:0045217)3.09570325
99semaphorin-plexin signaling pathway (GO:0071526)3.08892362
100regulation of complement activation (GO:0030449)3.08235377
101endochondral ossification (GO:0001958)3.07928487
102replacement ossification (GO:0036075)3.07928487
103retinoic acid metabolic process (GO:0042573)3.07541791
104glyoxylate metabolic process (GO:0046487)3.02843416
105positive regulation of chondrocyte differentiation (GO:0032332)3.02043790
106establishment or maintenance of monopolar cell polarity (GO:0061339)3.01442616
107establishment of monopolar cell polarity (GO:0061162)3.01442616
108chondrocyte proliferation (GO:0035988)3.01258397
109carnitine transport (GO:0015879)3.00962766
110amino-acid betaine transport (GO:0015838)3.00962766
111multicellular organismal water homeostasis (GO:0050891)3.00333128
112regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.98064725
113extracellular matrix disassembly (GO:0022617)2.97736634
114bone remodeling (GO:0046849)2.97153624
115embryonic skeletal joint morphogenesis (GO:0060272)2.96999447
116basement membrane organization (GO:0071711)2.95513918
117sulfur compound catabolic process (GO:0044273)2.94248671
118negative regulation of lipase activity (GO:0060192)2.94210112
119ear development (GO:0043583)2.93277058
120regulation of mesenchymal cell apoptotic process (GO:2001053)2.92977076
121proline metabolic process (GO:0006560)2.92237990
122phospholipid efflux (GO:0033700)2.91317045
123one-carbon compound transport (GO:0019755)2.89639713
124protein retention in ER lumen (GO:0006621)2.87668679
125negative regulation of sterol transport (GO:0032372)2.87313672
126negative regulation of cholesterol transport (GO:0032375)2.87313672
127establishment of planar polarity (GO:0001736)2.87066317
128establishment of tissue polarity (GO:0007164)2.87066317
129regulation of fibrinolysis (GO:0051917)2.85969268
130response to parathyroid hormone (GO:0071107)2.84470340
131complement activation, alternative pathway (GO:0006957)2.84301018
132glutathione biosynthetic process (GO:0006750)2.83788135
133positive regulation of cartilage development (GO:0061036)2.82461765
134regulation of extracellular matrix organization (GO:1903053)2.82446685
135vitamin catabolic process (GO:0009111)2.81927422
136fat-soluble vitamin catabolic process (GO:0042363)2.81927422
137regulation of integrin-mediated signaling pathway (GO:2001044)2.81358175
138short-chain fatty acid metabolic process (GO:0046459)2.80969307
139proteoglycan metabolic process (GO:0006029)2.80340639
140negative regulation of hemostasis (GO:1900047)2.79751395
141negative regulation of blood coagulation (GO:0030195)2.79751395
142positive regulation of hormone biosynthetic process (GO:0046886)2.76627041
143Notch signaling involved in heart development (GO:0061314)2.75372722
144surfactant homeostasis (GO:0043129)2.74696353
145response to lead ion (GO:0010288)2.74675030
146regulation of plasminogen activation (GO:0010755)2.72427182
147barbed-end actin filament capping (GO:0051016)2.71401264
148negative regulation of coagulation (GO:0050819)2.70843792
149tricarboxylic acid metabolic process (GO:0072350)2.70554502
150regulation of cholesterol esterification (GO:0010872)2.69525787
151positive regulation of hormone metabolic process (GO:0032352)2.69250949
152bone resorption (GO:0045453)2.69206641
153chondroitin sulfate biosynthetic process (GO:0030206)2.68389813
154vitamin transport (GO:0051180)2.67262931
155negative regulation of keratinocyte proliferation (GO:0010839)2.66848041
156sulfur compound transport (GO:0072348)2.66746226
157valine metabolic process (GO:0006573)2.66510045
158terpenoid biosynthetic process (GO:0016114)2.66291944
159primary alcohol metabolic process (GO:0034308)2.65493816
160tolerance induction (GO:0002507)2.60465429
161water homeostasis (GO:0030104)2.59805850
162cell junction maintenance (GO:0034331)2.58257053
163epoxygenase P450 pathway (GO:0019373)2.56419453
164positive regulation of smoothened signaling pathway (GO:0045880)2.56216758
165epithelial cell-cell adhesion (GO:0090136)2.53682117
166regulation of metalloenzyme activity (GO:0048552)2.50745555
167embryo implantation (GO:0007566)2.50210520
168cholesterol efflux (GO:0033344)2.50182851
169COPI coating of Golgi vesicle (GO:0048205)2.45305984
170Golgi transport vesicle coating (GO:0048200)2.45305984
171desmosome organization (GO:0002934)2.44893916
172negative regulation of immunoglobulin mediated immune response (GO:0002890)2.44789290
173negative regulation of B cell mediated immunity (GO:0002713)2.44789290
174negative regulation of wound healing (GO:0061045)2.44069539
175negative regulation of lipid transport (GO:0032369)2.43277863
176hydrogen peroxide biosynthetic process (GO:0050665)2.43129082
177regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.42573281
178retinol metabolic process (GO:0042572)2.42216748
179epithelial cell differentiation involved in prostate gland development (GO:0060742)2.41579492
180regulation of humoral immune response (GO:0002920)2.40150062
181amyloid precursor protein catabolic process (GO:0042987)2.39625208
182high-density lipoprotein particle remodeling (GO:0034375)2.38154431
183O-glycan processing (GO:0016266)2.37950442
184regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.37861713
185protein localization to endosome (GO:0036010)2.37581835
186apical protein localization (GO:0045176)2.31866262
187hyaluronan metabolic process (GO:0030212)2.28210810
188sperm capacitation (GO:0048240)2.26262546
189L-ascorbic acid metabolic process (GO:0019852)2.25062124
190axonemal dynein complex assembly (GO:0070286)11.6504216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.85465353
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.31713978
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.52977519
4ESR1_21235772_ChIP-Seq_MCF-7_Human4.37916751
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.70502293
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.51130298
7ESR2_21235772_ChIP-Seq_MCF-7_Human3.02224253
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.28331970
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.28271967
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22442884
11CLOCK_20551151_ChIP-Seq_293T_Human2.08662882
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.02760076
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.94233752
14FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90122533
15HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89813784
16CJUN_26792858_Chip-Seq_BT549_Human1.88803591
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82486739
18CDX2_20551321_ChIP-Seq_CACO-2_Human1.79701130
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78503822
20SOX2_20726797_ChIP-Seq_SW620_Human1.70654093
21* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68618272
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68592923
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63806929
24SMC4_20622854_ChIP-Seq_HELA_Human1.62034224
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60957796
26AR_21572438_ChIP-Seq_LNCaP_Human1.60841794
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.57049318
28DROSHA_22980978_ChIP-Seq_HELA_Human1.54909552
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54567814
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51011415
31P63_26484246_Chip-Seq_KERATINOCYTES_Human1.49995670
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.49105955
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46939010
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.45829323
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45534633
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45396074
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45396074
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45234427
39TP63_22573176_ChIP-Seq_HFKS_Human1.44538880
40* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43959544
41GATA1_22025678_ChIP-Seq_K562_Human1.41805710
42* TP53_22127205_ChIP-Seq_IMR90_Human1.40646655
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.39968528
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38538295
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38538295
46VDR_24787735_ChIP-Seq_THP-1_Human1.38185440
47ZNF263_19887448_ChIP-Seq_K562_Human1.37919045
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37468520
49ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36227968
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35067790
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34455576
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.34296173
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34132428
54P68_20966046_ChIP-Seq_HELA_Human1.33804309
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33738545
56LXR_22158963_ChIP-Seq_LIVER_Mouse1.33338052
57RXR_22108803_ChIP-Seq_LS180_Human1.31374571
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.30175132
59ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29598330
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28560140
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28547595
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28349553
63CTCF_27219007_Chip-Seq_Bcells_Human1.26139928
64KDM2B_26808549_Chip-Seq_K562_Human1.25849387
65* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24889795
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21355120
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.20288737
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.20288737
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.19829966
70RACK7_27058665_Chip-Seq_MCF-7_Human1.18539674
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18086789
72BCOR_27268052_Chip-Seq_Bcells_Human1.17406712
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17019658
74GATA4_25053715_ChIP-Seq_YYC3_Human1.15645922
75EGR1_19032775_ChIP-ChIP_M12_Human1.15607351
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15364689
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14871338
78CREB1_26743006_Chip-Seq_LNCaP_Human1.14725349
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14612039
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.14190263
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13205787
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12810034
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11845059
84GATA3_24758297_ChIP-Seq_MCF-7_Human1.09314627
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.08834274
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08243817
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08099381
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07445903
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.07147762
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07067263
91* TP53_18474530_ChIP-ChIP_U2OS_Human1.07011241
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06762109
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06696030
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06173639
95* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05854059
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05423357
97FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03120811
98* TCF7_22412390_ChIP-Seq_EML_Mouse1.03057077
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02798017
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01056965
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.00435275
102EED_16625203_ChIP-ChIP_MESCs_Mouse0.99862521
103* TP63_23658742_ChIP-Seq_EP156T_Human0.98979574
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98900324
105* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98764367
106TP53_23651856_ChIP-Seq_MEFs_Mouse0.97986639
107UBF1/2_26484160_Chip-Seq_HMECs_Human0.97954922
108SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97533456
109BCL6_27268052_Chip-Seq_Bcells_Human0.97452182
110STAT1_20625510_ChIP-Seq_HELA_Human0.96906688
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96466320
112AHR_22903824_ChIP-Seq_MCF-7_Human0.96346245
113TET1_21451524_ChIP-Seq_MESCs_Mouse0.95317035
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95224000
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93986153
116GATA1_19941826_ChIP-Seq_K562_Human0.93678994
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93518119
118CTCF_20526341_ChIP-Seq_ESCs_Human0.93156169
119LXR_22292898_ChIP-Seq_THP-1_Human0.92971478
120* VDR_24763502_ChIP-Seq_THP-1_Human0.92968491
121SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92370549
122BP1_19119308_ChIP-ChIP_Hs578T_Human0.91926778
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.91314867
124RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90091316
125EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90091316
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90022434
127* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88497506
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88485790
129TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87410251
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87209139
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87208931
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.86290325
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.85659265
134KLF5_25053715_ChIP-Seq_YYC3_Human0.85508345
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.84471015
136PIAS1_25552417_ChIP-Seq_VCAP_Human0.83556630
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.83283219
138SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82867375
139SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82616007
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.81506647
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81092921
142GATA6_25053715_ChIP-Seq_YYC3_Human0.80927279
143TP53_20018659_ChIP-ChIP_R1E_Mouse0.80607833
144ATF3_27146783_Chip-Seq_COLON_Human0.80242584
145NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79946853
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78094159
147HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77829406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation3.64760054
2MP0002933_joint_inflammation3.19249556
3MP0005503_abnormal_tendon_morphology3.14996427
4MP0005360_urolithiasis3.14892962
5MP0004019_abnormal_vitamin_homeostasis3.13630960
6MP0009840_abnormal_foam_cell2.96796003
7MP0002138_abnormal_hepatobiliary_system2.93562503
8MP0001958_emphysema2.90932210
9MP0002282_abnormal_trachea_morphology2.90777396
10MP0003195_calcinosis2.83164642
11MP0004134_abnormal_chest_morphology2.71227299
12MP0000163_abnormal_cartilage_morphology2.64078872
13MP0005377_hearing/vestibular/ear_phenot2.50550310
14MP0003878_abnormal_ear_physiology2.50550310
15MP0009643_abnormal_urine_homeostasis2.48991935
16MP0002132_abnormal_respiratory_system2.47992046
17MP0005365_abnormal_bile_salt2.47244262
18MP0005332_abnormal_amino_acid2.43147978
19MP0001765_abnormal_ion_homeostasis2.41034249
20MP0003646_muscle_fatigue2.33200624
21MP0002115_abnormal_skeleton_extremities2.31453950
22MP0001756_abnormal_urination2.30533819
23MP0002896_abnormal_bone_mineralization2.29628614
24MP0008438_abnormal_cutaneous_collagen2.27711216
25MP0002136_abnormal_kidney_physiology2.27094586
26MP0005275_abnormal_skin_tensile2.20313601
27MP0004272_abnormal_basement_membrane2.11087710
28MP0000762_abnormal_tongue_morphology2.09853521
29MP0009250_abnormal_appendicular_skeleto2.08359863
30MP0003566_abnormal_cell_adhesion1.95268148
31MP0003705_abnormal_hypodermis_morpholog1.93337697
32MP0005058_abnormal_lysosome_morphology1.92492366
33MP0004133_heterotaxia1.88218505
34MP0002113_abnormal_skeleton_development1.85779951
35MP0003453_abnormal_keratinocyte_physiol1.82817704
36MP0004858_abnormal_nervous_system1.80759624
37MP0005257_abnormal_intraocular_pressure1.80758911
38MP0002653_abnormal_ependyma_morphology1.75363493
39MP0005508_abnormal_skeleton_morphology1.72561070
40MP0001270_distended_abdomen1.70225344
41MP0002089_abnormal_postnatal_growth/wei1.69707750
42MP0003300_gastrointestinal_ulcer1.68828289
43MP0001533_abnormal_skeleton_physiology1.66991866
44MP0002139_abnormal_hepatobiliary_system1.64775372
45MP0000538_abnormal_urinary_bladder1.59562836
46MP0009780_abnormal_chondrocyte_physiolo1.59070333
47MP0005390_skeleton_phenotype1.58342874
48MP0010234_abnormal_vibrissa_follicle1.55762040
49MP0003283_abnormal_digestive_organ1.54437711
50MP0005636_abnormal_mineral_homeostasis1.54180109
51MP0005085_abnormal_gallbladder_physiolo1.52740154
52MP0000467_abnormal_esophagus_morphology1.52180996
53MP0003795_abnormal_bone_structure1.51857749
54MP0010368_abnormal_lymphatic_system1.45633054
55MP0002998_abnormal_bone_remodeling1.40984484
56MP0008004_abnormal_stomach_pH1.38672049
57MP0009278_abnormal_bone_marrow1.37360944
58MP0002108_abnormal_muscle_morphology1.33089358
59MP0003941_abnormal_skin_development1.32431002
60MP0002277_abnormal_respiratory_mucosa1.31850673
61MP0005083_abnormal_biliary_tract1.30249929
62MP0009384_cardiac_valve_regurgitation1.30190492
63MP0003252_abnormal_bile_duct1.29681373
64MP0005164_abnormal_response_to1.28383095
65MP0000858_altered_metastatic_potential1.28256961
66MP0001542_abnormal_bone_strength1.28246451
67MP0000604_amyloidosis1.25447356
68MP0002098_abnormal_vibrissa_morphology1.25205108
69MP0002109_abnormal_limb_morphology1.24411066
70MP0002168_other_aberrant_phenotype1.21465181
71MP0001299_abnormal_eye_distance/1.18288524
72MP0003303_peritoneal_inflammation1.16183413
73MP0003950_abnormal_plasma_membrane1.16009584
74MP0003186_abnormal_redox_activity1.15081323
75MP0003279_aneurysm1.14430758
76MP0001666_abnormal_nutrient_absorption1.13706443
77MP0000383_abnormal_hair_follicle1.09076819
78MP0002796_impaired_skin_barrier1.08189758
79MP0008789_abnormal_olfactory_epithelium1.08002467
80MP0002060_abnormal_skin_morphology1.07543778
81MP0010030_abnormal_orbit_morphology1.06805654
82MP0005408_hypopigmentation1.06730838
83MP0003436_decreased_susceptibility_to1.05286135
84MP0003075_altered_response_to1.05223724
85MP0008260_abnormal_autophagy1.04750581
86MP0002928_abnormal_bile_duct1.03515835
87MP0005076_abnormal_cell_differentiation1.02867370
88MP0006082_CNS_inflammation1.02107409
89MP0000534_abnormal_ureter_morphology1.01984683
90MP0000432_abnormal_head_morphology0.99753496
91MP0005395_other_phenotype0.98988215
92MP0000751_myopathy0.96764566
93MP0005023_abnormal_wound_healing0.95884807
94MP0002116_abnormal_craniofacial_bone0.95863098
95MP0005451_abnormal_body_composition0.95549679
96MP0000566_synostosis0.94525321
97MP0002249_abnormal_larynx_morphology0.92472066
98MP0005409_darkened_coat_color0.92162654
99MP0002876_abnormal_thyroid_physiology0.92109216
100MP0006054_spinal_hemorrhage0.90735536
101MP0000678_abnormal_parathyroid_gland0.90672842
102MP0010678_abnormal_skin_adnexa0.90170965
103MP0003329_amyloid_beta_deposits0.90147230
104MP0003191_abnormal_cellular_cholesterol0.90092702
105MP0003755_abnormal_palate_morphology0.89946746
106MP0001915_intracranial_hemorrhage0.89488214
107MP0002135_abnormal_kidney_morphology0.89429819
108MP0000343_altered_response_to0.88108360
109MP0002254_reproductive_system_inflammat0.87821516
110MP0005165_increased_susceptibility_to0.84819072
111MP0004883_abnormal_blood_vessel0.82960445
112MP0001849_ear_inflammation0.82956457
113MP0000049_abnormal_middle_ear0.81994186
114MP0003656_abnormal_erythrocyte_physiolo0.81792709
115MP0010155_abnormal_intestine_physiology0.81582399
116MP0005666_abnormal_adipose_tissue0.80883934
117MP0002233_abnormal_nose_morphology0.80732519
118MP0004264_abnormal_extraembryonic_tissu0.80298836
119MP0000681_abnormal_thyroid_gland0.79493002
120MP0000767_abnormal_smooth_muscle0.78550634
121MP0002295_abnormal_pulmonary_circulatio0.77957754
122MP0002111_abnormal_tail_morphology0.75376456
123MP0004947_skin_inflammation0.75288681
124MP0001216_abnormal_epidermal_layer0.74928173
125MP0005501_abnormal_skin_physiology0.74771010
126MP0000230_abnormal_systemic_arterial0.74262949
127MP0003091_abnormal_cell_migration0.74080119
128MP0004885_abnormal_endolymph0.72716488
129MP0000377_abnormal_hair_follicle0.72271434
130MP0001984_abnormal_olfaction0.71441744
131MP0003172_abnormal_lysosome_physiology0.71133086
132MP0008875_abnormal_xenobiotic_pharmacok0.69841490
133MP0000249_abnormal_blood_vessel0.69135210
134MP0008961_abnormal_basal_metabolism0.69128918
135MP0009053_abnormal_anal_canal0.68013171
136MP0002419_abnormal_innate_immunity0.67344327
137MP0003634_abnormal_glial_cell0.67156430
138MP0003942_abnormal_urinary_system0.64978936
139MP0005623_abnormal_meninges_morphology0.64246512
140MP0005670_abnormal_white_adipose0.62963348
141MP0002932_abnormal_joint_morphology0.62494831
142MP0005367_renal/urinary_system_phenotyp0.61993051
143MP0000516_abnormal_urinary_system0.61993051
144MP0005381_digestive/alimentary_phenotyp0.61860756
145MP0001663_abnormal_digestive_system0.61586865
146MP0005084_abnormal_gallbladder_morpholo0.61309680

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.51543908
2Abnormal respiratory epithelium morphology (HP:0012253)8.37386749
3Abnormal respiratory motile cilium morphology (HP:0005938)8.37386749
4Abnormal respiratory motile cilium physiology (HP:0012261)8.12579181
5Absent/shortened dynein arms (HP:0200106)8.07329403
6Dynein arm defect of respiratory motile cilia (HP:0012255)8.07329403
7Abnormal ciliary motility (HP:0012262)7.93510919
8Rhinitis (HP:0012384)7.40745801
9* Epiphyseal dysplasia (HP:0002656)7.25643314
10Delayed epiphyseal ossification (HP:0002663)6.21841642
11Irregular epiphyses (HP:0010582)5.88911734
12Nasal polyposis (HP:0100582)5.86078295
13Chronic bronchitis (HP:0004469)5.80042621
14Abnormality of the nasal mucosa (HP:0000433)5.50315758
15Abnormal tarsal ossification (HP:0008369)5.31555269
16Bronchiectasis (HP:0002110)5.25442592
17Vitreoretinal degeneration (HP:0000655)5.05958520
18Metaphyseal cupping (HP:0003021)5.02168215
19Small epiphyses (HP:0010585)4.67916663
20Hypoplastic ischia (HP:0003175)4.59357745
21Cupped ribs (HP:0000887)4.40273045
22Neonatal short-limb short stature (HP:0008921)4.38091485
23Abnormality of the ischium (HP:0003174)4.02187876
24Abnormal foot bone ossification (HP:0010675)3.99360688
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.98509503
26* Genu varum (HP:0002970)3.98243732
27Hypokalemic alkalosis (HP:0001949)3.91802625
28Flat capital femoral epiphysis (HP:0003370)3.90916477
29Metabolic alkalosis (HP:0200114)3.88922016
30Enlarged epiphyses (HP:0010580)3.82709808
31Increased circulating renin level (HP:0000848)3.79089605
32Hyperactive renin-angiotensin system (HP:0000841)3.75644526
33Metaphyseal dysplasia (HP:0100255)3.74548994
34Cervical subluxation (HP:0003308)3.66973106
35Male infertility (HP:0003251)3.62568738
36Mild short stature (HP:0003502)3.60860362
37Abnormality of chloride homeostasis (HP:0011422)3.50907309
38* Flat acetabular roof (HP:0003180)3.45017798
39Hypomagnesemia (HP:0002917)3.42919414
40Polyuria (HP:0000103)3.35879239
41Gout (HP:0001997)3.29247853
42Abnormality of monocarboxylic acid metabolism (HP:0010996)3.28583538
43Infertility (HP:0000789)3.27761124
44Recurrent otitis media (HP:0000403)3.25124394
45Recurrent sinusitis (HP:0011108)3.21069962
46Atelectasis (HP:0100750)3.16772222
47Tetany (HP:0001281)3.14408691
48Abnormal urine output (HP:0012590)3.11006130
49Abnormality of renal excretion (HP:0011036)3.10726265
50Abnormality of femoral epiphyses (HP:0006499)3.08366297
51Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.08366297
52Osteoarthritis (HP:0002758)3.05949164
53Abnormality of the vertebral endplates (HP:0005106)3.05683866
54Flattened epiphyses (HP:0003071)3.05003385
55Protuberant abdomen (HP:0001538)3.03444575
56* Metaphyseal irregularity (HP:0003025)3.01907776
57Bronchitis (HP:0012387)2.96416844
58* Abnormality of carpal bone ossification (HP:0006257)2.89135530
59* Platyspondyly (HP:0000926)2.86473533
60Abnormality of the epiphysis of the femoral head (HP:0010574)2.81304898
61Deep venous thrombosis (HP:0002625)2.78841993
62Abnormality of magnesium homeostasis (HP:0004921)2.78162740
63Hyperuricemia (HP:0002149)2.76103300
64Increased purine levels (HP:0004368)2.76103300
65Proximal tubulopathy (HP:0000114)2.75823555
66Arthropathy (HP:0003040)2.71451315
67Hypercalciuria (HP:0002150)2.70561761
68Hydroxyprolinuria (HP:0003080)2.70031555
69Abnormality of proline metabolism (HP:0010907)2.70031555
70Ovoid vertebral bodies (HP:0003300)2.68583281
71Irregular vertebral endplates (HP:0003301)2.68462112
72Chronic sinusitis (HP:0011109)2.67277578
73Occipital encephalocele (HP:0002085)2.66756242
74Abnormality of glutamine family amino acid metabolism (HP:0010902)2.66627190
75Beaking of vertebral bodies (HP:0004568)2.62087355
76Absent epiphyses (HP:0010577)2.61833555
77Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.61833555
78Abnormality of the femoral head (HP:0003368)2.59440471
79Protrusio acetabuli (HP:0003179)2.59025391
80* Abnormal vertebral ossification (HP:0100569)2.58835201
81Polydipsia (HP:0001959)2.57820245
82Abnormal drinking behavior (HP:0030082)2.57820245
83Renal salt wasting (HP:0000127)2.49978002
84Systemic lupus erythematosus (HP:0002725)2.45855408
85Vascular calcification (HP:0004934)2.41865821
86* Abnormal ossification of hand bones (HP:0005921)2.40734435
87* Short femoral neck (HP:0100864)2.39686764
88Bell-shaped thorax (HP:0001591)2.38631653
89Complement deficiency (HP:0004431)2.38111878
90Abnormality of liposaccharide metabolism (HP:0010968)2.37922928
91Abnormality of glycosphingolipid metabolism (HP:0004343)2.37922928
92Abnormality of glycolipid metabolism (HP:0010969)2.37922928
93Hyperaldosteronism (HP:0000859)2.36579694
94Stillbirth (HP:0003826)2.35465579
95Abnormality of renin-angiotensin system (HP:0000847)2.32716678
96Vertebral clefting (HP:0008428)2.30237579
97* Coxa vara (HP:0002812)2.29685395
98* Abnormal hand bone ossification (HP:0010660)2.28636236
99Abnormality of the Achilles tendon (HP:0005109)2.27304765
100Achilles tendon contracture (HP:0001771)2.26882806
101Cardiovascular calcification (HP:0011915)2.26756656
102Chronic otitis media (HP:0000389)2.26099206
103Premature rupture of membranes (HP:0001788)2.25869003
104Exostoses (HP:0100777)2.25104666
105Abnormality of purine metabolism (HP:0004352)2.22544120
106Abnormality of the proximal phalanges of the hand (HP:0009834)2.21390124
107* Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.19149404
108Mucopolysacchariduria (HP:0008155)2.16979991
109Urinary glycosaminoglycan excretion (HP:0003541)2.16979991
110Abnormality of polysaccharide metabolism (HP:0011012)2.14657091
111Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14657091
112Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14657091
113Abnormality of complement system (HP:0005339)2.13408284
114Renal tubular acidosis (HP:0001947)2.12283047
115Abnormality of the pubic bones (HP:0003172)2.11957345
116Alkalosis (HP:0001948)2.10854580
117Short nail (HP:0001799)2.10850896
118* Limited hip movement (HP:0008800)2.10591550
119* Hypoplasia of the odontoid process (HP:0003311)2.09737019
120Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09226912
121Mesomelia (HP:0003027)2.08328647
122Ulnar deviation of the wrist (HP:0003049)2.08076724
123Nuclear cataract (HP:0100018)2.05614166
124* Waddling gait (HP:0002515)2.05128000
125Dysostosis multiplex (HP:0000943)2.04362504
126Glomerulonephritis (HP:0000099)2.01102683
127Lumbar hyperlordosis (HP:0002938)1.97816449
128Thoracolumbar scoliosis (HP:0002944)1.97581779
129* Hip contracture (HP:0003273)1.97346532
130Absent frontal sinuses (HP:0002688)1.94707246
131Abnormality of dentin (HP:0010299)1.92136613
132* Aplasia/hypoplasia of the femur (HP:0005613)1.90590329
133Hemorrhage of the eye (HP:0011885)1.90492778
134Advanced eruption of teeth (HP:0006288)1.90240550
135Hepatoblastoma (HP:0002884)1.88655737
136Limited elbow extension (HP:0001377)1.87433907
137Tibial bowing (HP:0002982)1.86796187
138Femoral bowing (HP:0002980)1.85110014
139Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.84301382
140J-shaped sella turcica (HP:0002680)1.83523196
141* Barrel-shaped chest (HP:0001552)1.83516038
142Vertebral compression fractures (HP:0002953)1.83334972
143Purpura (HP:0000979)1.82573932
144* Abnormality of the odontoid process (HP:0003310)1.82501980
145Thin bony cortex (HP:0002753)1.82273011
146Mitral stenosis (HP:0001718)1.80467681
147Mixed hearing impairment (HP:0000410)1.80206373
148Ulnar bowing (HP:0003031)1.77647688
149Abnormality of the 2nd finger (HP:0004100)1.77545470
150Enlarged kidneys (HP:0000105)1.76979495
151Increased cerebral lipofuscin (HP:0011813)1.74284764
152Tubulointerstitial nephritis (HP:0001970)1.70061980
153Xanthomatosis (HP:0000991)1.69132496
154Cerebral aneurysm (HP:0004944)1.68534463
155Neurofibrillary tangles (HP:0002185)1.66991159
156Loss of speech (HP:0002371)1.65680267
157Natal tooth (HP:0000695)1.65219999
158Long toe (HP:0010511)1.65006397
159Myocardial infarction (HP:0001658)1.64799964
160Cystic liver disease (HP:0006706)1.63282841
161Malnutrition (HP:0004395)1.63239838
162* Upper limb amyotrophy (HP:0009129)1.61682860
163* Distal upper limb amyotrophy (HP:0007149)1.61682860
164Nephritis (HP:0000123)1.59568539
165Mildly elevated creatine phosphokinase (HP:0008180)1.57488459
166Vascular tortuosity (HP:0004948)1.57200156
167Glucose intolerance (HP:0000833)1.56165450
168Lip pit (HP:0100267)1.54851625
169Arterial tortuosity (HP:0005116)1.54393896
170Joint stiffness (HP:0001387)1.52816538
171Atrophic scars (HP:0001075)1.50843430
172Broad face (HP:0000283)1.49827633
173Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.49380764
174Shallow orbits (HP:0000586)1.48479869
175Increased neuronal autofluorescent lipopigment (HP:0002074)1.44427842
176* Hand muscle atrophy (HP:0009130)1.41076068
177Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.39380152
178Hypoalphalipoproteinemia (HP:0003233)1.39362873
179Abnormality of aromatic amino acid family metabolism (HP:0004338)1.38340670
180Thick nail (HP:0001805)1.37612844
181Bifid scrotum (HP:0000048)1.36189798
182Recurrent gram-negative bacterial infections (HP:0005420)1.35265029
183Aneurysm (HP:0002617)1.32804008
184Thoracic kyphosis (HP:0002942)1.31057655
185Abnormality of molar (HP:0011077)1.29209747
186Abnormality of molar morphology (HP:0011070)1.29209747
187Abnormality of the dental root (HP:0006486)1.27482225
188Taurodontia (HP:0000679)1.27482225
189Abnormality of permanent molar morphology (HP:0011071)1.27482225
190Polygenic inheritance (HP:0010982)1.26912613
191Amyloidosis (HP:0011034)1.25830932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK46.50825134
2DDR25.47666221
3WNK34.84126576
4OXSR14.57505569
5STK38L3.70204579
6MAP3K33.69634924
7STK393.09159106
8SMG12.66260733
9PRKG22.44859811
10MST42.42440632
11EPHB12.01998858
12EPHA21.99526021
13MAPKAPK31.93792576
14TGFBR21.83551729
15ICK1.82535500
16TTN1.76982977
17EPHB21.74530173
18MAP3K61.65935135
19EEF2K1.59849746
20TESK11.58185648
21MAP3K71.56293447
22TRPM71.55735513
23MST1R1.53788620
24WNK11.49098478
25LATS11.46177450
26CDC42BPA1.41787320
27PDK21.40418290
28CDK121.27202854
29MAP3K131.25957577
30TIE11.24512366
31RIPK11.22987436
32PAK41.22854156
33ERBB31.22375505
34STK241.19940169
35SIK11.17676299
36TRIB31.12337820
37MARK21.08187203
38NME11.06504547
39LRRK21.00750435
40SGK4940.99947926
41SGK2230.99947926
42ARAF0.99145346
43IRAK30.97287647
44ZAP700.96898476
45GSK3A0.95820184
46PIM20.95621843
47PKN20.93611229
48PTK20.91044025
49MAP3K110.90544753
50FER0.89348787
51ERN10.87382520
52STK100.86729639
53MET0.84443195
54TTK0.82385391
55BCKDK0.81117602
56PDPK10.80837315
57ROCK10.80467335
58TAOK20.79648283
59NUAK10.79081298
60EPHA30.78969164
61STK30.78905482
62MAP3K140.77930088
63TAOK10.74555397
64MAP2K30.73770566
65PTK60.73757812
66LMTK20.72324281
67MAP3K10.71093849
68RPS6KA20.68781461
69MAPK150.67797839
70ERBB40.66086651
71FRK0.65143228
72NTRK10.64383017
73STK380.64304135
74SGK30.63891625
75CLK10.63227586
76PRKCI0.61818259
77MYLK0.61420257
78DYRK1B0.61377658
79BLK0.58586106
80NEK90.56613106
81SGK20.55618549
82PTK2B0.54965410
83ERBB20.53614255
84BMX0.53041690
85PDGFRB0.51777010
86FGFR40.51389774
87PDK30.50677938
88PDK40.50677938
89MOS0.48330592
90MAP3K80.47302837
91PRPF4B0.44880146
92JAK10.44530179
93CAMK1D0.44429946
94HIPK20.41172695
95CHUK0.39755888
96LATS20.39138382
97PLK20.37448037
98MAPK120.36605700
99PIK3CA0.35888526
100PAK30.35045606
101TGFBR10.35001914
102RET0.34393990
103CAMK1G0.34387239
104MUSK0.32482895
105TBK10.32448102
106MATK0.31304849
107LIMK10.31262260
108ROCK20.30343194
109IGF1R0.30201243
110PAK20.29669124
111ABL20.28719133
112FGFR30.28373380
113ILK0.27914740
114RPS6KL10.27691030
115RPS6KC10.27691030
116ABL10.27409096
117MAPK70.27178159
118IKBKB0.27126578
119CAMK2G0.26620073
120FGFR10.25899584
121INSR0.25839345
122PAK10.25816979
123MAP2K10.24917858
124AKT20.24648029
125* SRC0.24312393
126CDK90.23804085
127MAP2K20.23472507
128MAPK40.23458803
129PRKCE0.23375468
130PRKCH0.22684390
131MAP3K20.21496000
132NME20.21077828
133PRKD20.20650882
134CSF1R0.20011603
135PIM10.20010250
136PRKAA20.19464070
137PDGFRA0.19431554
138CSK0.16757266
139NEK60.16601545
140TYK20.16296666
141* PRKCD0.15430367
142* SGK10.14624665
143TEC0.14437491
144EGFR0.13509231
145MTOR0.11157916

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein digestion and absorption_Homo sapiens_hsa049743.94681657
2ECM-receptor interaction_Homo sapiens_hsa045123.52668135
3Complement and coagulation cascades_Homo sapiens_hsa046103.14988088
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.90806183
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.90069506
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.78704568
7Other glycan degradation_Homo sapiens_hsa005112.77268348
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.75948481
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.70244657
10Tyrosine metabolism_Homo sapiens_hsa003502.54126919
11Vitamin digestion and absorption_Homo sapiens_hsa049772.35382814
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26779816
13Sulfur metabolism_Homo sapiens_hsa009202.18165865
14Butanoate metabolism_Homo sapiens_hsa006502.10668561
15Propanoate metabolism_Homo sapiens_hsa006401.95247808
16Mineral absorption_Homo sapiens_hsa049781.91929291
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89742182
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.88308483
19Collecting duct acid secretion_Homo sapiens_hsa049661.86344386
20Glutathione metabolism_Homo sapiens_hsa004801.71183515
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69689719
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.66593279
23Caffeine metabolism_Homo sapiens_hsa002321.64774967
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59743209
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.59365016
26Focal adhesion_Homo sapiens_hsa045101.57071556
27Peroxisome_Homo sapiens_hsa041461.55640205
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53510710
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51650964
30Lysine degradation_Homo sapiens_hsa003101.51541011
31Notch signaling pathway_Homo sapiens_hsa043301.41580547
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40047847
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.39049249
34Lysosome_Homo sapiens_hsa041421.37769765
35Arginine and proline metabolism_Homo sapiens_hsa003301.36500841
36beta-Alanine metabolism_Homo sapiens_hsa004101.35903711
37Bile secretion_Homo sapiens_hsa049761.30893050
38Starch and sucrose metabolism_Homo sapiens_hsa005001.27211033
39Sphingolipid metabolism_Homo sapiens_hsa006001.25549843
40Fatty acid degradation_Homo sapiens_hsa000711.20898884
41Thyroid hormone synthesis_Homo sapiens_hsa049181.16013810
42ABC transporters_Homo sapiens_hsa020101.15959329
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15248561
44Tryptophan metabolism_Homo sapiens_hsa003801.14097417
45Pyruvate metabolism_Homo sapiens_hsa006201.10326283
46Prion diseases_Homo sapiens_hsa050201.10196506
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08489288
48Arachidonic acid metabolism_Homo sapiens_hsa005901.00351762
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95585212
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93730776
51Malaria_Homo sapiens_hsa051440.93612794
52Pertussis_Homo sapiens_hsa051330.90451936
53Arginine biosynthesis_Homo sapiens_hsa002200.88576582
54Phagosome_Homo sapiens_hsa041450.85992244
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85729867
56Proteoglycans in cancer_Homo sapiens_hsa052050.84852824
57Fatty acid metabolism_Homo sapiens_hsa012120.83628119
58PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81004007
59PPAR signaling pathway_Homo sapiens_hsa033200.80831974
60Amoebiasis_Homo sapiens_hsa051460.77327710
61Renin-angiotensin system_Homo sapiens_hsa046140.76262902
62Basal cell carcinoma_Homo sapiens_hsa052170.73978972
63Chemical carcinogenesis_Homo sapiens_hsa052040.73919067
64Gastric acid secretion_Homo sapiens_hsa049710.73628815
65Selenocompound metabolism_Homo sapiens_hsa004500.73520300
66Steroid biosynthesis_Homo sapiens_hsa001000.72875016
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70514379
68Adherens junction_Homo sapiens_hsa045200.69443368
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68820946
70Hippo signaling pathway_Homo sapiens_hsa043900.68446170
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67679249
72Rheumatoid arthritis_Homo sapiens_hsa053230.67228739
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.66891443
74Hedgehog signaling pathway_Homo sapiens_hsa043400.65299231
75Vibrio cholerae infection_Homo sapiens_hsa051100.65111677
76TGF-beta signaling pathway_Homo sapiens_hsa043500.64884555
77Phenylalanine metabolism_Homo sapiens_hsa003600.63670478
78Bladder cancer_Homo sapiens_hsa052190.60784619
79Staphylococcus aureus infection_Homo sapiens_hsa051500.60437353
80Small cell lung cancer_Homo sapiens_hsa052220.58826129
81Linoleic acid metabolism_Homo sapiens_hsa005910.57168956
82Carbon metabolism_Homo sapiens_hsa012000.57119480
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56602715
84TNF signaling pathway_Homo sapiens_hsa046680.56274997
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54827415
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54113910
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52909378
88Galactose metabolism_Homo sapiens_hsa000520.51888096
89Folate biosynthesis_Homo sapiens_hsa007900.48519337
90Histidine metabolism_Homo sapiens_hsa003400.47350426
91Circadian rhythm_Homo sapiens_hsa047100.44871173
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44117315
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43276374
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42736380
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41946674
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40810904
97Retinol metabolism_Homo sapiens_hsa008300.39893508
98Pentose phosphate pathway_Homo sapiens_hsa000300.39689616
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38558308
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.38043573
101Sulfur relay system_Homo sapiens_hsa041220.37822444
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37211994
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36345132
104Biosynthesis of amino acids_Homo sapiens_hsa012300.36288764
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35933334
106Influenza A_Homo sapiens_hsa051640.34533573
107Salmonella infection_Homo sapiens_hsa051320.34430846
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33960362
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33403736
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32819887
111Toxoplasmosis_Homo sapiens_hsa051450.31317174
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.31109696
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31023058
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30472222
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29867929
116Tuberculosis_Homo sapiens_hsa051520.29484703
117Osteoclast differentiation_Homo sapiens_hsa043800.29361548
118Endocytosis_Homo sapiens_hsa041440.29075369
119Insulin resistance_Homo sapiens_hsa049310.28106755
120Ovarian steroidogenesis_Homo sapiens_hsa049130.28064754
121N-Glycan biosynthesis_Homo sapiens_hsa005100.27157438
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27148228
123Dilated cardiomyopathy_Homo sapiens_hsa054140.26673386
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26388329
125Choline metabolism in cancer_Homo sapiens_hsa052310.26380741
126Glycerolipid metabolism_Homo sapiens_hsa005610.26173811
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25625677
128Leishmaniasis_Homo sapiens_hsa051400.25049059
129Tight junction_Homo sapiens_hsa045300.24067466
130Hepatitis C_Homo sapiens_hsa051600.21530746
131Fructose and mannose metabolism_Homo sapiens_hsa000510.20941436
132Metabolic pathways_Homo sapiens_hsa011000.20327240
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20082649

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