TRPV6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. Translation initiation for this protein occurs at a non-AUG start codon that is decoded as methionine. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prostate gland growth (GO:0060736)7.90661990
2estrogen metabolic process (GO:0008210)7.23663721
3female pregnancy (GO:0007565)6.91099473
4glucocorticoid biosynthetic process (GO:0006704)6.80145900
5response to follicle-stimulating hormone (GO:0032354)6.69539538
6iron ion import (GO:0097286)6.29954876
7androgen biosynthetic process (GO:0006702)6.16827133
8regulation of gonadotropin secretion (GO:0032276)6.12260534
9sulfate transmembrane transport (GO:1902358)5.82577929
10multi-multicellular organism process (GO:0044706)5.09955992
11chondrocyte proliferation (GO:0035988)4.94890421
12androgen metabolic process (GO:0008209)4.89853612
13glucocorticoid metabolic process (GO:0008211)4.65373647
14multi-organism reproductive process (GO:0044703)4.61166886
15endocrine hormone secretion (GO:0060986)4.53958096
16desmosome organization (GO:0002934)4.53084872
17sulfate transport (GO:0008272)4.51895931
18negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.50782097
19keratinization (GO:0031424)4.48796575
20regulation of autophagic vacuole assembly (GO:2000785)4.35594704
21negative regulation of macroautophagy (GO:0016242)4.33228593
22positive regulation of growth hormone secretion (GO:0060124)4.31765428
23regulation of acrosome reaction (GO:0060046)4.25734830
24myoblast fusion (GO:0007520)4.21529314
25regulation of water loss via skin (GO:0033561)4.15087488
26establishment of skin barrier (GO:0061436)4.13338339
27hemidesmosome assembly (GO:0031581)4.10476189
28keratinocyte development (GO:0003334)4.07287299
29positive regulation of protein kinase C signaling (GO:0090037)4.01808005
30negative regulation of T cell differentiation in thymus (GO:0033085)4.00490334
31insulin-like growth factor receptor signaling pathway (GO:0048009)3.98896833
32hormone biosynthetic process (GO:0042446)3.97177440
33syncytium formation (GO:0006949)3.90667406
34interferon-gamma secretion (GO:0072643)3.89550897
35import into cell (GO:0098657)3.89415743
36syncytium formation by plasma membrane fusion (GO:0000768)3.87134940
37positive regulation of keratinocyte differentiation (GO:0045618)3.85310258
38negative regulation of keratinocyte proliferation (GO:0010839)3.84981929
39endothelial cell chemotaxis (GO:0035767)3.82068605
40citrulline biosynthetic process (GO:0019240)3.80919340
41biotin metabolic process (GO:0006768)3.73881816
42epithelial cell maturation (GO:0002070)3.70513670
43vascular endothelial growth factor signaling pathway (GO:0038084)3.69660179
44regulation of clathrin-mediated endocytosis (GO:2000369)3.64210496
45myelin maintenance (GO:0043217)3.63458762
46vitamin transmembrane transport (GO:0035461)3.62790601
47epithelial cell-cell adhesion (GO:0090136)3.59643547
48collecting duct development (GO:0072044)3.59095813
49sphingoid metabolic process (GO:0046519)3.47301155
50bundle of His cell to Purkinje myocyte communication (GO:0086069)3.44980445
51linoleic acid metabolic process (GO:0043651)3.44832143
52negative regulation of organelle assembly (GO:1902116)3.43895097
53regulation of vacuole organization (GO:0044088)3.43260376
54regulation of hippo signaling (GO:0035330)3.43100670
55extracellular matrix assembly (GO:0085029)3.42976558
56protein retention in ER lumen (GO:0006621)3.41118893
57regulation of receptor binding (GO:1900120)3.27004873
58sulfur amino acid catabolic process (GO:0000098)3.26412741
59ovulation from ovarian follicle (GO:0001542)3.25656901
60maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23864089
613-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.23553677
62purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.23553677
63JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.22638710
64negative regulation of protein tyrosine kinase activity (GO:0061099)3.21017935
65calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.20968559
66fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.20899354
67fucose catabolic process (GO:0019317)3.20687267
68L-fucose metabolic process (GO:0042354)3.20687267
69L-fucose catabolic process (GO:0042355)3.20687267
70sulfur compound transport (GO:0072348)3.19113359
71positive regulation of chemokine secretion (GO:0090197)3.16150125
72pyrimidine-containing compound transmembrane transport (GO:0072531)3.15937500
73intestinal epithelial cell development (GO:0060576)3.15624788
74prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.14134109
75keratinocyte differentiation (GO:0030216)3.12142080
76galactose catabolic process (GO:0019388)3.10396985
77positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.09161327
78ear development (GO:0043583)3.08371603
79mammary gland epithelial cell differentiation (GO:0060644)3.07096720
80positive regulation of T cell differentiation in thymus (GO:0033089)3.06904542
81fucose metabolic process (GO:0006004)3.02452956
82transcytosis (GO:0045056)3.01546484
83histone H3-K9 demethylation (GO:0033169)3.01139697
84zinc ion transport (GO:0006829)2.96022881
85somite development (GO:0061053)2.95442022
86regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.95046233
87negative regulation of alpha-beta T cell differentiation (GO:0046639)2.92492057
88sequestering of extracellular ligand from receptor (GO:0035581)2.91808122
89regulation of chemokine secretion (GO:0090196)2.90292093
90multicellular organismal water homeostasis (GO:0050891)2.89742930
91polarized epithelial cell differentiation (GO:0030859)2.87478558
92branching involved in prostate gland morphogenesis (GO:0060442)2.87159713
93establishment of protein localization to Golgi (GO:0072600)2.83227116
94regulation of endocrine process (GO:0044060)2.82987454
95positive regulation of glycoprotein biosynthetic process (GO:0010560)2.82509363
96retinal metabolic process (GO:0042574)2.80593478
97artery development (GO:0060840)2.79468008
98regulation of viral release from host cell (GO:1902186)2.76999728
99interkinetic nuclear migration (GO:0022027)2.75572447
100carnitine transmembrane transport (GO:1902603)2.74512570
101hypotonic response (GO:0006971)2.74467614
102regulation of ruffle assembly (GO:1900027)2.70243945
103positive regulation of epidermal cell differentiation (GO:0045606)2.69825549
104L-serine transport (GO:0015825)2.69286220
105positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.69267677
106regulation of keratinocyte differentiation (GO:0045616)2.68565325
107face development (GO:0060324)2.68184320
108lung lobe morphogenesis (GO:0060463)2.67175112
109carnitine shuttle (GO:0006853)2.66997797
110vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.66420499
111amino-acid betaine transport (GO:0015838)2.66315392
112carnitine transport (GO:0015879)2.66315392
113antibacterial humoral response (GO:0019731)2.66240886
114pyrimidine ribonucleoside catabolic process (GO:0046133)2.65599565
115regulation of growth hormone secretion (GO:0060123)2.63768630
116N-glycan processing (GO:0006491)2.63609829
117positive regulation of glycoprotein metabolic process (GO:1903020)2.62373795
118response to gonadotropin (GO:0034698)2.60453319
119establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.60041235
120cellular potassium ion homeostasis (GO:0030007)2.58375459
121bile acid and bile salt transport (GO:0015721)2.58263125
122macroautophagy (GO:0016236)2.58135948
123protein kinase C signaling (GO:0070528)2.57664302
124cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.57566392
125fibroblast migration (GO:0010761)2.57311428
126quaternary ammonium group transport (GO:0015697)2.55314220
127toxin transport (GO:1901998)2.54904324
128plasma membrane repair (GO:0001778)2.54738042
129retrograde transport, vesicle recycling within Golgi (GO:0000301)2.54624370
130long-chain fatty acid biosynthetic process (GO:0042759)2.52102952
131phosphatidylserine metabolic process (GO:0006658)2.52095653
132epidermis development (GO:0008544)2.50910808
133antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50856128
134antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.50856128
135bone morphogenesis (GO:0060349)2.49879371
136regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.49340520
137antimicrobial humoral response (GO:0019730)2.49227068
138positive regulation of guanylate cyclase activity (GO:0031284)2.47855340
139keratinocyte proliferation (GO:0043616)2.46878897
140regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.45867077
141cytoskeletal anchoring at plasma membrane (GO:0007016)2.44888656
142cell communication involved in cardiac conduction (GO:0086065)2.44410281
143regulation of protein localization to cell surface (GO:2000008)2.44361887
144water homeostasis (GO:0030104)2.44075701
145embryonic camera-type eye morphogenesis (GO:0048596)2.43764884
146ER overload response (GO:0006983)2.43621688
147antigen processing and presentation via MHC class Ib (GO:0002475)2.42872256
148regulation of keratinocyte proliferation (GO:0010837)2.42554795
149phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.41452529
150phosphatidylcholine biosynthetic process (GO:0006656)2.41337653
151regulation of guanylate cyclase activity (GO:0031282)2.41265958
152positive regulation of steroid hormone secretion (GO:2000833)2.40854782
153bone resorption (GO:0045453)2.40386358
154adherens junction assembly (GO:0034333)2.39879702
155epidermal cell differentiation (GO:0009913)2.39471216
156columnar/cuboidal epithelial cell development (GO:0002066)2.39080125
157phosphatidylserine acyl-chain remodeling (GO:0036150)2.38592692
158chemical homeostasis within a tissue (GO:0048875)2.38188833
159synaptic vesicle docking involved in exocytosis (GO:0016081)2.36161453
160* regulation of calcium ion-dependent exocytosis (GO:0017158)2.34890021
161negative regulation of receptor activity (GO:2000272)2.34263975
162positive regulation of chondrocyte differentiation (GO:0032332)2.32161574
163regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.32096701
164sodium ion export (GO:0071436)2.31579142
165exocrine pancreas development (GO:0031017)2.30139832
166apical protein localization (GO:0045176)2.29450054
167vocalization behavior (GO:0071625)2.26680600
168surfactant homeostasis (GO:0043129)2.26417946
169Golgi transport vesicle coating (GO:0048200)2.26013685
170COPI coating of Golgi vesicle (GO:0048205)2.26013685
171protein targeting to Golgi (GO:0000042)2.25480159
172angiotensin maturation (GO:0002003)2.24663099
173regulation of pH (GO:0006885)2.24493807
174phosphatidylinositol acyl-chain remodeling (GO:0036149)2.23914551
175positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.23641865
176peptidyl-tyrosine autophosphorylation (GO:0038083)2.22786412
177estrogen biosynthetic process (GO:0006703)15.1697719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.46781383
2* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human5.10467135
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.83003405
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43391294
5CDX2_19796622_ChIP-Seq_MESCs_Mouse2.39287503
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37232485
7EGR1_19032775_ChIP-ChIP_M12_Human2.28457268
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.18544060
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.09695692
10* SOX2_20726797_ChIP-Seq_SW620_Human2.06290325
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.04957273
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.04349151
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01654248
14HIF1A_21447827_ChIP-Seq_MCF-7_Human1.98312885
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92584718
16AR_21909140_ChIP-Seq_LNCAP_Human1.92283977
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90305656
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89888081
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89888081
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.87078503
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85072133
22SOX2_27498859_Chip-Seq_STOMACH_Mouse1.84576877
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83288191
24AHR_22903824_ChIP-Seq_MCF-7_Human1.81992557
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81426138
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.80006847
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79827000
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79478169
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78930748
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.74257267
31AR_21572438_ChIP-Seq_LNCaP_Human1.74104396
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72683593
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72592035
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71021534
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67166961
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64097656
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.62517222
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60136471
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.55849202
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.54354520
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52842722
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.52420008
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51889005
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.50712165
45CHD1_26751641_Chip-Seq_LNCaP_Human1.48789620
46ZNF263_19887448_ChIP-Seq_K562_Human1.47070183
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.46572819
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.46320618
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45529133
50FOXA1_25552417_ChIP-Seq_VCAP_Human1.43595844
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.42444777
52TCF4_18268006_ChIP-ChIP_LS174T_Human1.41477012
53DROSHA_22980978_ChIP-Seq_HELA_Human1.36817140
54KLF5_25053715_ChIP-Seq_YYC3_Human1.34959325
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.34824256
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33750975
57EZH2_22144423_ChIP-Seq_EOC_Human1.31703652
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31304199
59BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.29740658
60RXR_22108803_ChIP-Seq_LS180_Human1.29728846
61GATA4_25053715_ChIP-Seq_YYC3_Human1.27669512
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26870675
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23543454
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23461955
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21156610
66ZNF274_21170338_ChIP-Seq_K562_Hela1.13866375
67* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13440528
68RACK7_27058665_Chip-Seq_MCF-7_Human1.12268516
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11716984
70ELF5_23300383_ChIP-Seq_T47D_Human1.11627885
71* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10151767
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10112301
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.09033323
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.08971271
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08738750
76GATA6_25053715_ChIP-Seq_YYC3_Human1.08025242
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07594352
78GATA3_24758297_ChIP-Seq_MCF-7_Human1.05873909
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04344385
80PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03860496
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02759172
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00811110
83VDR_22108803_ChIP-Seq_LS180_Human1.00036005
84FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99287684
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98618372
86PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98467281
87KDM2B_26808549_Chip-Seq_K562_Human0.98037820
88GATA1_22025678_ChIP-Seq_K562_Human0.97988158
89SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97655844
90NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97543917
91* PIAS1_25552417_ChIP-Seq_VCAP_Human0.96572782
92TP53_18474530_ChIP-ChIP_U2OS_Human0.96498284
93RING1B_27294783_Chip-Seq_ESCs_Mouse0.96317199
94FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96020669
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96004266
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95736914
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95702987
98* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95076939
99P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94090143
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94063609
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94063609
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92659611
103NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92548404
104CLOCK_20551151_ChIP-Seq_293T_Human0.92376216
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92256097
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91808966
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91630268
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90925544
109CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89773145
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89254824
111TP53_20018659_ChIP-ChIP_R1E_Mouse0.89043397
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88721402
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87125914
114CBX2_27304074_Chip-Seq_ESCs_Mouse0.86719214
115ATF3_27146783_Chip-Seq_COLON_Human0.86523870
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86115000
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.86053887
118CREB1_26743006_Chip-Seq_LNCaP_Human0.85634161
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85429479
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84602920
121RING1B_27294783_Chip-Seq_NPCs_Mouse0.84213639
122LXR_22292898_ChIP-Seq_THP-1_Human0.83718427
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.83185810
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82956322
125AR_25329375_ChIP-Seq_VCAP_Human0.82645738
126TP63_23658742_ChIP-Seq_EP156T_Human0.82075009
127TP63_22573176_ChIP-Seq_HFKS_Human0.81795272
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.81752530
129CJUN_26792858_Chip-Seq_BT549_Human0.81361474
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80550225
131RARB_27405468_Chip-Seq_BRAIN_Mouse0.80406548
132SMAD4_21799915_ChIP-Seq_A2780_Human0.80180978
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.80100412
134TBX20_22080862_ChIP-Seq_HEART_Mouse0.80100412
135P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78763193
136SMC4_20622854_ChIP-Seq_HELA_Human0.78156813
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77275646
138EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.74911091
139CTCF_27219007_Chip-Seq_Bcells_Human0.74680101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle9.02599780
2MP0003283_abnormal_digestive_organ5.94942458
3MP0009697_abnormal_copulation4.81106048
4MP0002822_catalepsy4.76207744
5MP0005379_endocrine/exocrine_gland_phen3.98715201
6MP0002163_abnormal_gland_morphology3.64167315
7MP0002796_impaired_skin_barrier3.08275622
8MP0005647_abnormal_sex_gland2.82410404
9MP0001919_abnormal_reproductive_system2.77868337
10MP0005377_hearing/vestibular/ear_phenot2.71671513
11MP0003878_abnormal_ear_physiology2.71671513
12MP0003315_abnormal_perineum_morphology2.65258392
13MP0000462_abnormal_digestive_system2.61742786
14MP0006276_abnormal_autonomic_nervous2.56099818
15MP0002876_abnormal_thyroid_physiology2.51622372
16MP0010678_abnormal_skin_adnexa2.49322046
17MP0002234_abnormal_pharynx_morphology2.26248641
18MP0003183_abnormal_peptide_metabolism2.23379303
19MP0005670_abnormal_white_adipose2.20013498
20MP0002254_reproductive_system_inflammat2.13568439
21MP0000537_abnormal_urethra_morphology2.09549511
22MP0001346_abnormal_lacrimal_gland2.07328682
23MP0004885_abnormal_endolymph2.03495670
24MP0010386_abnormal_urinary_bladder2.03030792
25* MP0001666_abnormal_nutrient_absorption1.91110924
26MP0005275_abnormal_skin_tensile1.85995620
27MP0005248_abnormal_Harderian_gland1.84728315
28MP0003936_abnormal_reproductive_system1.81242611
29MP0009780_abnormal_chondrocyte_physiolo1.76288543
30MP0002098_abnormal_vibrissa_morphology1.75160327
31MP0001664_abnormal_digestion1.67783583
32MP0005167_abnormal_blood-brain_barrier1.65741003
33MP0003941_abnormal_skin_development1.64979766
34MP0004043_abnormal_pH_regulation1.64465334
35MP0005310_abnormal_salivary_gland1.56348224
36* MP0001765_abnormal_ion_homeostasis1.55817693
37MP0004264_abnormal_extraembryonic_tissu1.55348224
38MP0009053_abnormal_anal_canal1.55109321
39MP0003868_abnormal_feces_composition1.49855874
40MP0001501_abnormal_sleep_pattern1.48160347
41MP0003959_abnormal_lean_body1.46888246
42MP0005501_abnormal_skin_physiology1.45935570
43MP0004858_abnormal_nervous_system1.44988218
44MP0004510_myositis1.43932738
45MP0005058_abnormal_lysosome_morphology1.41225353
46MP0004859_abnormal_synaptic_plasticity1.39852925
47MP0002168_other_aberrant_phenotype1.39745410
48MP0001873_stomach_inflammation1.36442458
49MP0006138_congestive_heart_failure1.34687151
50MP0005410_abnormal_fertilization1.34569008
51MP0010368_abnormal_lymphatic_system1.34105722
52MP0003566_abnormal_cell_adhesion1.34016439
53MP0003045_fibrosis1.33724073
54MP0002909_abnormal_adrenal_gland1.33005230
55MP0000003_abnormal_adipose_tissue1.31268974
56MP0000538_abnormal_urinary_bladder1.31081531
57MP0000566_synostosis1.31036198
58MP0008004_abnormal_stomach_pH1.29606614
59MP0001216_abnormal_epidermal_layer1.23248858
60MP0005381_digestive/alimentary_phenotyp1.21589059
61MP0000762_abnormal_tongue_morphology1.21145413
62MP0005389_reproductive_system_phenotype1.19800779
63MP0002060_abnormal_skin_morphology1.18306206
64MP0003866_abnormal_defecation1.17274878
65MP0002653_abnormal_ependyma_morphology1.16008888
66MP0010771_integument_phenotype1.15626420
67MP0002009_preneoplasia1.15487713
68MP0001485_abnormal_pinna_reflex1.12764650
69MP0005375_adipose_tissue_phenotype1.11605256
70MP0008875_abnormal_xenobiotic_pharmacok1.10971544
71MP0005666_abnormal_adipose_tissue1.08173656
72MP0004036_abnormal_muscle_relaxation1.05590771
73MP0004233_abnormal_muscle_weight1.04443749
74MP0000427_abnormal_hair_cycle1.03544629
75MP0005083_abnormal_biliary_tract1.02902912
76MP0003385_abnormal_body_wall1.00938594
77MP0001881_abnormal_mammary_gland1.00737726
78MP0004185_abnormal_adipocyte_glucose1.00264608
79MP0001879_abnormal_lymphatic_vessel0.99618753
80* MP0001756_abnormal_urination0.99416699
81MP0008057_abnormal_DNA_replication0.98592798
82MP0000383_abnormal_hair_follicle0.98497818
83MP0003879_abnormal_hair_cell0.96840592
84MP0000534_abnormal_ureter_morphology0.96677651
85MP0004270_analgesia0.95971737
86MP0009384_cardiac_valve_regurgitation0.95678313
87MP0003011_delayed_dark_adaptation0.94601865
88MP0003880_abnormal_central_pattern0.93173422
89MP0003191_abnormal_cellular_cholesterol0.92546076
90MP0005395_other_phenotype0.92232830
91MP0003705_abnormal_hypodermis_morpholog0.91830518
92MP0003635_abnormal_synaptic_transmissio0.91318480
93MP0000377_abnormal_hair_follicle0.91206036
94MP0001968_abnormal_touch/_nociception0.90428342
95MP0009703_decreased_birth_body0.89114394
96MP0004085_abnormal_heartbeat0.88875812
97MP0000613_abnormal_salivary_gland0.88754876
98MP0004272_abnormal_basement_membrane0.88675450
99MP0000230_abnormal_systemic_arterial0.87634904
100MP0010329_abnormal_lipoprotein_level0.85490073
101MP0009115_abnormal_fat_cell0.83214720
102MP0004381_abnormal_hair_follicle0.82764070
103MP0002896_abnormal_bone_mineralization0.82387779
104MP0005220_abnormal_exocrine_pancreas0.82387313
105MP0002108_abnormal_muscle_morphology0.81397275
106MP0005076_abnormal_cell_differentiation0.80551221
107MP0003638_abnormal_response/metabolism_0.79625791
108MP0001440_abnormal_grooming_behavior0.79622904
109MP0002166_altered_tumor_susceptibility0.79434183
110MP0001663_abnormal_digestive_system0.79282209
111MP0001849_ear_inflammation0.79116114
112MP0010352_gastrointestinal_tract_polyps0.78568031
113MP0000681_abnormal_thyroid_gland0.78089054
114MP0000627_abnormal_mammary_gland0.76125032
115MP0003453_abnormal_keratinocyte_physiol0.75341612
116MP0002733_abnormal_thermal_nociception0.74707040
117MP0005187_abnormal_penis_morphology0.73771605
118MP0006072_abnormal_retinal_apoptosis0.73504199
119MP0000604_amyloidosis0.73392138
120MP0003300_gastrointestinal_ulcer0.70449524
121MP0003950_abnormal_plasma_membrane0.70421309
122MP0005084_abnormal_gallbladder_morpholo0.69344279
123MP0002736_abnormal_nociception_after0.69024519
124MP0004742_abnormal_vestibular_system0.68585247
125MP0003329_amyloid_beta_deposits0.68452827
126MP0000013_abnormal_adipose_tissue0.68127034
127MP0000477_abnormal_intestine_morphology0.67110889
128MP0004084_abnormal_cardiac_muscle0.66985303
129* MP0005636_abnormal_mineral_homeostasis0.66763602
130MP0004782_abnormal_surfactant_physiolog0.66519978
131MP0000678_abnormal_parathyroid_gland0.66249344
132MP0005646_abnormal_pituitary_gland0.66008610
133MP0000470_abnormal_stomach_morphology0.65078613
134MP0002734_abnormal_mechanical_nocicepti0.64028265
135MP0005085_abnormal_gallbladder_physiolo0.63982233
136MP0000778_abnormal_nervous_system0.63905701
137MP0003937_abnormal_limbs/digits/tail_de0.63765922
138MP0009250_abnormal_appendicular_skeleto0.63724510
139MP0001970_abnormal_pain_threshold0.63004811
140* MP0009643_abnormal_urine_homeostasis0.62471825
141MP0005408_hypopigmentation0.62310736
142MP0001944_abnormal_pancreas_morphology0.62302509
143MP0002063_abnormal_learning/memory/cond0.61781325
144* MP0000367_abnormal_coat/_hair0.60479066
145MP0009745_abnormal_behavioral_response0.58711212
146MP0001340_abnormal_eyelid_morphology0.58344150
147* MP0004947_skin_inflammation0.58312127
148MP0006054_spinal_hemorrhage0.57590074
149MP0005257_abnormal_intraocular_pressure0.57530134
150MP0000579_abnormal_nail_morphology0.57162988
151MP0000647_abnormal_sebaceous_gland0.55132871
152MP0002006_tumorigenesis0.54971756
153MP0004484_altered_response_of0.54639846

Predicted human phenotypes

RankGene SetZ-score
1Symphalangism affecting the phalanges of the hand (HP:0009773)6.29395918
2Abnormality of the 2nd finger (HP:0004100)5.06054428
3Abnormality of the proximal phalanges of the hand (HP:0009834)4.99998933
4Sparse lateral eyebrow (HP:0005338)4.86435918
5Abnormality of the middle phalanges of the toes (HP:0010183)4.75818317
6Amelogenesis imperfecta (HP:0000705)4.66357767
7Abnormality of the distal phalanx of the thumb (HP:0009617)4.58236078
8Flat acetabular roof (HP:0003180)4.54918582
9Abnormality of the 1st metacarpal (HP:0010009)4.37941696
10Lip pit (HP:0100267)4.37113696
11Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)4.34424382
12Fragile nails (HP:0001808)4.11624665
13Short hallux (HP:0010109)3.99068969
14Decreased circulating renin level (HP:0003351)3.96897903
15Neonatal short-limb short stature (HP:0008921)3.87803486
16Cupped ribs (HP:0000887)3.79950995
17Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.68964445
18Aplasia/Hypoplasia of the hallux (HP:0008362)3.64900293
19Onycholysis (HP:0001806)3.61639908
20Capillary hemangiomas (HP:0005306)3.50972236
21Posterior subcapsular cataract (HP:0007787)3.50300710
22Tracheal stenosis (HP:0002777)3.49459564
23Right ventricular cardiomyopathy (HP:0011663)3.47604056
24Abnormality of the axillary hair (HP:0100134)3.32499368
25Abnormality of secondary sexual hair (HP:0009888)3.32499368
26Hyperactive renin-angiotensin system (HP:0000841)3.24412043
27Shawl scrotum (HP:0000049)3.24351035
28Flat capital femoral epiphysis (HP:0003370)3.20774695
29Abnormality of cochlea (HP:0000375)3.20112745
30Vacuolated lymphocytes (HP:0001922)3.17991124
31Aplasia/hypoplasia of the femur (HP:0005613)3.14433748
32Short phalanx of the thumb (HP:0009660)3.13584064
33Absent phalangeal crease (HP:0006109)3.11786966
34Spinal cord compression (HP:0002176)3.09520571
35Renal salt wasting (HP:0000127)3.03870970
36Pili torti (HP:0003777)3.02434308
37Intrahepatic cholestasis (HP:0001406)3.01921797
38Upper limb muscle weakness (HP:0003484)2.99714526
39Hyperkalemia (HP:0002153)2.95574989
40Woolly hair (HP:0002224)2.94848567
41Abnormality of carpal bone ossification (HP:0006257)2.94021824
42Hypergonadotropic hypogonadism (HP:0000815)2.93142841
43Short middle phalanx of finger (HP:0005819)2.91654932
44Aplasia involving bones of the upper limbs (HP:0009823)2.89905608
45Aplasia of the phalanges of the hand (HP:0009802)2.89905608
46Aplasia involving bones of the extremities (HP:0009825)2.89905608
47Accelerated skeletal maturation (HP:0005616)2.83002183
48Abnormality of the distal phalanges of the toes (HP:0010182)2.82756011
49Abnormality of the ischium (HP:0003174)2.80551268
50Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.73469606
51Congenital sensorineural hearing impairment (HP:0008527)2.73168550
52Breech presentation (HP:0001623)2.72564040
53Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.70732386
54Hypoplasia of the ulna (HP:0003022)2.70640473
55Abnormal finger flexion creases (HP:0006143)2.70473892
56Testicular neoplasm (HP:0010788)2.70457866
57Dysmetric saccades (HP:0000641)2.68632016
58Milia (HP:0001056)2.67058258
59Congenital ichthyosiform erythroderma (HP:0007431)2.65881542
60Hyperaldosteronism (HP:0000859)2.65367102
61Abnormality of the middle phalanges of the hand (HP:0009833)2.61382534
62Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.58038924
63Vertebral hypoplasia (HP:0008417)2.58038924
64Subcapsular cataract (HP:0000523)2.50398806
65Flattened epiphyses (HP:0003071)2.50136258
66Short tibia (HP:0005736)2.50068167
67Abnormal vertebral ossification (HP:0100569)2.48835896
68Hypoplasia of the uterus (HP:0000013)2.47679289
69Atrophic scars (HP:0001075)2.46258727
70Irregular epiphyses (HP:0010582)2.45680860
71Down-sloping shoulders (HP:0200021)2.44808108
72Hypoplastic ilia (HP:0000946)2.44258068
73Lumbar hyperlordosis (HP:0002938)2.42847991
74Abnormal auditory evoked potentials (HP:0006958)2.42524727
75Azoospermia (HP:0000027)2.41860728
76Progressive cerebellar ataxia (HP:0002073)2.41168727
77Relative macrocephaly (HP:0004482)2.39967057
78Abnormal ossification of hand bones (HP:0005921)2.39763376
79Malnutrition (HP:0004395)2.39516875
80Plantar hyperkeratosis (HP:0007556)2.39313934
81Abnormal cartilage morphology (HP:0002763)2.38967351
82Genetic anticipation (HP:0003743)2.38368409
83Testicular atrophy (HP:0000029)2.37704135
84Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.37561344
85Hyporeflexia of lower limbs (HP:0002600)2.37345632
86Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.36287740
87Abdominal distention (HP:0003270)2.34052637
88Bronchomalacia (HP:0002780)2.33221814
89Abnormality of the phalanges of the hallux (HP:0010057)2.32627468
90Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.31346058
91Advanced eruption of teeth (HP:0006288)2.29763470
92Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.29283507
93Prostate neoplasm (HP:0100787)2.28806005
94Abnormal hand bone ossification (HP:0010660)2.28293389
95Germ cell neoplasia (HP:0100728)2.28134830
96Flared iliac wings (HP:0002869)2.24619083
97Hyperparathyroidism (HP:0000843)2.24285472
98Concave nail (HP:0001598)2.21870248
99Exotropia (HP:0000577)2.21829060
100Exocrine pancreatic insufficiency (HP:0001738)2.21281931
101Abnormal pancreas size (HP:0012094)2.21119440
102Ulnar deviation of finger (HP:0009465)2.20646881
103Short femoral neck (HP:0100864)2.20167159
104Abnormality of renin-angiotensin system (HP:0000847)2.17589822
105Dysostosis multiplex (HP:0000943)2.17581535
106Aplasia/Hypoplasia of the tibia (HP:0005772)2.14777914
107Distal lower limb muscle weakness (HP:0009053)2.14774158
108Oligomenorrhea (HP:0000876)2.14094575
109Severe Myopia (HP:0011003)2.13904658
110Alopecia of scalp (HP:0002293)2.13559582
111Aortic aneurysm (HP:0004942)2.12694322
112Depressed nasal tip (HP:0000437)2.12419571
113Hypoplastic nipples (HP:0002557)2.11276955
114Vertebral clefting (HP:0008428)2.10016650
115Large earlobe (HP:0009748)2.08550882
116Abnormality of the nasal septum (HP:0000419)2.08341929
117Short humerus (HP:0005792)2.08265170
118Hip contracture (HP:0003273)2.08254470
119Hip dysplasia (HP:0001385)2.07838620
120Aplasia/Hypoplasia of the ulna (HP:0006495)2.07195835
121Steatorrhea (HP:0002570)2.07186099
122Coronal craniosynostosis (HP:0004440)2.06771575
123Short 1st metacarpal (HP:0010034)2.06737625
124Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.06737625
125Gaze-evoked nystagmus (HP:0000640)2.05832144
126Morphological abnormality of the inner ear (HP:0011390)2.04035193
127Female pseudohermaphroditism (HP:0010458)2.03307203
128Fat malabsorption (HP:0002630)2.02769442
129Hoarse voice (HP:0001609)2.02567612
130Abnormality of the dental root (HP:0006486)2.01443975
131Taurodontia (HP:0000679)2.01443975
132Abnormality of permanent molar morphology (HP:0011071)2.01443975
133Ridged nail (HP:0001807)2.01374929
134Tubulointerstitial nephritis (HP:0001970)1.98575142
135Curly hair (HP:0002212)1.98228856
136Microretrognathia (HP:0000308)1.98061091
137Visceral angiomatosis (HP:0100761)1.97776644
138Abnormality of the aortic arch (HP:0012303)1.97285313
139Abnormal foot bone ossification (HP:0010675)1.97069444
140Villous atrophy (HP:0011473)1.97008037
141Abnormality of small intestinal villus morphology (HP:0011472)1.97008037
142Abnormality of chloride homeostasis (HP:0011422)1.95419880
143Severe short stature (HP:0003510)1.95294763
144Neoplasm of the heart (HP:0100544)1.94518297
145Thin bony cortex (HP:0002753)1.92569005
146Ovoid vertebral bodies (HP:0003300)1.91314358
147Nonimmune hydrops fetalis (HP:0001790)1.91154311
148Congenital glaucoma (HP:0001087)1.90589831
149Abnormal hair laboratory examination (HP:0003328)1.90370731
150Bundle branch block (HP:0011710)1.90240273
151Abnormal pupillary function (HP:0007686)1.89740100
152Abnormality of the epiphyses of the hand (HP:0005924)1.89407299
153Dysdiadochokinesis (HP:0002075)1.89165963
154Broad face (HP:0000283)1.88107406
155Gonadotropin excess (HP:0000837)1.87778261
156Gout (HP:0001997)1.87418524
157Macroorchidism (HP:0000053)1.86762952
158Focal motor seizures (HP:0011153)1.86698889
159Obstructive sleep apnea (HP:0002870)1.85486875
160Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85481878
161Infertility (HP:0000789)1.85105821
162Abnormality of molar (HP:0011077)1.85006754
163Abnormality of molar morphology (HP:0011070)1.85006754
164Septate vagina (HP:0001153)1.84773629
165Hypoplastic labia majora (HP:0000059)1.84644769
166Biliary tract neoplasm (HP:0100574)1.84493419
167Broad metatarsal (HP:0001783)1.84242874
168Syncope (HP:0001279)1.84199221
169Aplasia/Hypoplasia of the nipples (HP:0006709)1.83392098
170Long palpebral fissure (HP:0000637)1.81798228
171Abnormality of macular pigmentation (HP:0008002)1.81656089
172Cone-rod dystrophy (HP:0000548)1.81620226
173Skin pits (HP:0100276)1.81250071
174Abnormality of the dental pulp (HP:0006479)1.80695464
175Abnormal tarsal ossification (HP:0008369)1.80690465
176Vascular calcification (HP:0004934)1.80432137
177Popliteal pterygium (HP:0009756)1.79391316
178Lower limb asymmetry (HP:0100559)1.77973782
179Short nail (HP:0001799)1.77565550
180Clumsiness (HP:0002312)1.77178006
181Sensorimotor neuropathy (HP:0007141)1.76024608
182Tongue fasciculations (HP:0001308)1.75953613
183Breast carcinoma (HP:0003002)1.74162540
184Abnormality of the fingertips (HP:0001211)1.72546490
185Hydroxyprolinuria (HP:0003080)1.69830634

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK38.78392760
2MST1R6.50562118
3PIK3CA3.52733780
4EPHB23.25048932
5MAP3K22.98199729
6TNK22.70865764
7PKN22.57926937
8KSR22.54665445
9KDR2.48504893
10CAMK1D2.46033220
11AKT32.40098776
12MET2.38973681
13PDGFRA2.17587880
14MST42.17226846
15MAP3K92.13174046
16STK38L2.05032005
17STK382.02527312
18FRK1.95046450
19PRKD31.94365864
20CAMK1G1.92986978
21STK391.91490537
22EPHA21.77211146
23MAP3K121.71270944
24MAP2K21.70658903
25MYLK1.62413089
26OXSR11.59853086
27CDK121.54747582
28LMTK21.47307305
29FER1.34399667
30MAP2K11.23440037
31SGK2231.13206350
32SGK4941.13206350
33NME11.13083068
34MAP3K41.12715902
35EPHA41.11879613
36MTOR1.08410057
37INSRR1.07259296
38MAPKAPK31.05814392
39EEF2K1.05013331
40PRKAA21.03280821
41RIPK41.01785938
42SGK21.00519679
43RIPK10.98404843
44ERN10.98106771
45MAPK150.95957207
46LATS10.94136184
47MARK10.92883782
48TAOK10.92851543
49NEK60.91569081
50EPHA30.89189099
51MAP3K70.88480999
52SGK30.87263346
53MAP3K10.85971868
54PTK20.85574312
55PTK60.81089891
56MAP2K60.80566781
57DMPK0.76955290
58DAPK20.76947608
59NTRK30.75163948
60PRKAA10.73148210
61PDK20.73054932
62RET0.72185831
63ARAF0.71565795
64CDC42BPA0.71256038
65CDK190.70598827
66GRK60.69367525
67PRKG20.67376817
68SMG10.66434441
69MAP2K40.64296189
70PRKD20.62958906
71PIK3CG0.60636184
72PTK2B0.60352133
73GRK10.59339283
74WNK40.57933126
75PRKCI0.56100056
76LATS20.56009209
77PDPK10.55794436
78FGFR20.55493618
79CASK0.54287342
80BRSK20.53910146
81RPS6KB20.53529946
82ILK0.53204567
83BCKDK0.53032210
84FGFR40.52333761
85WNK10.50015046
86TTN0.49810149
87MAP3K130.48300023
88CHUK0.47750772
89PHKG20.46803764
90PHKG10.46803764
91CAMK2D0.43132849
92PDK10.42780863
93DDR20.42510543
94TESK10.40406077
95CDK50.40320853
96MAPK130.40259033
97CDK70.40075242
98EPHB10.39533477
99SGK10.38595506
100BLK0.37282231
101PRKCZ0.36489724
102TRIB30.36469811
103CAMK10.36240317
104ROCK10.35975649
105DAPK10.34534484
106STK30.34491175
107TBK10.33930217
108TRPM70.33827832
109CAMK2B0.32802001
110DAPK30.32528128
111NTRK10.32156200
112ERBB20.30869318
113SRC0.29356405
114YES10.29212040
115TAF10.28401457
116PRKD10.27976161
117FGFR10.27534528
118BMPR1B0.27453305
119PDGFRB0.27227529
120MELK0.27036745
121NLK0.26620784
122PAK30.26574244
123MAPKAPK50.26464614
124RAF10.26379878
125MATK0.26241217
126PAK20.25880434
127RPS6KA20.25593085
128ICK0.25313740
129LRRK20.24787733
130MINK10.24782766
131HIPK20.24671074
132MAPK120.24293389
133FYN0.24046514
134KSR10.23824860
135STK110.23619005
136CAMK2A0.23175278
137ROCK20.22515491
138MAPK80.22089622
139GRK50.21942915
140PRKCE0.21184014
141PRKCH0.20479082
142ADRBK10.18644245
143TYRO30.18417144
144MAP3K30.18410544
145SIK10.18382727
146CAMK2G0.15980245
147MAP2K70.15937247
148MARK20.15928291
149JAK20.15217472
150FGR0.15203739
151PLK20.15099155

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.12222864
2Ovarian steroidogenesis_Homo sapiens_hsa049134.47652265
3Steroid hormone biosynthesis_Homo sapiens_hsa001403.74611963
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.81513053
5Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.57789474
6ABC transporters_Homo sapiens_hsa020102.37465105
7Pancreatic secretion_Homo sapiens_hsa049722.34018876
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.13590501
9* Mineral absorption_Homo sapiens_hsa049782.05576719
10Fatty acid biosynthesis_Homo sapiens_hsa000612.02144267
11Phenylalanine metabolism_Homo sapiens_hsa003601.99241738
12* Salivary secretion_Homo sapiens_hsa049701.67146408
13Prostate cancer_Homo sapiens_hsa052151.65316230
14Fat digestion and absorption_Homo sapiens_hsa049751.47169871
15Vitamin digestion and absorption_Homo sapiens_hsa049771.46221579
16Vibrio cholerae infection_Homo sapiens_hsa051101.43453643
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.38389516
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37793047
19Thyroid hormone synthesis_Homo sapiens_hsa049181.35571328
20Synaptic vesicle cycle_Homo sapiens_hsa047211.32080047
21Protein digestion and absorption_Homo sapiens_hsa049741.30894135
22Gastric acid secretion_Homo sapiens_hsa049711.29243162
23beta-Alanine metabolism_Homo sapiens_hsa004101.26488905
24Circadian rhythm_Homo sapiens_hsa047101.24128188
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22555935
26Renin-angiotensin system_Homo sapiens_hsa046141.21696417
27Sulfur relay system_Homo sapiens_hsa041221.21599887
28Other glycan degradation_Homo sapiens_hsa005111.17976398
29Arginine and proline metabolism_Homo sapiens_hsa003301.16689648
30Tight junction_Homo sapiens_hsa045301.16403318
31Long-term potentiation_Homo sapiens_hsa047201.15992044
32Renin secretion_Homo sapiens_hsa049241.14222942
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12415754
34ErbB signaling pathway_Homo sapiens_hsa040121.11762054
35Bile secretion_Homo sapiens_hsa049761.11555918
36Collecting duct acid secretion_Homo sapiens_hsa049661.09582140
37Estrogen signaling pathway_Homo sapiens_hsa049151.09278036
38Nicotine addiction_Homo sapiens_hsa050331.07586890
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.06795121
40Insulin resistance_Homo sapiens_hsa049311.06166600
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05837901
42Prolactin signaling pathway_Homo sapiens_hsa049171.05369143
43Inositol phosphate metabolism_Homo sapiens_hsa005621.03015171
44Axon guidance_Homo sapiens_hsa043601.02850748
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02636535
46AMPK signaling pathway_Homo sapiens_hsa041520.99770523
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99472045
48Endometrial cancer_Homo sapiens_hsa052130.98071741
49Circadian entrainment_Homo sapiens_hsa047130.97923693
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95162594
51Insulin secretion_Homo sapiens_hsa049110.93651045
52Amphetamine addiction_Homo sapiens_hsa050310.93573088
53Thyroid cancer_Homo sapiens_hsa052160.89480363
54Glutamatergic synapse_Homo sapiens_hsa047240.88738587
55Fructose and mannose metabolism_Homo sapiens_hsa000510.88383648
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.88366497
57PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87941204
58VEGF signaling pathway_Homo sapiens_hsa043700.87763164
59Gap junction_Homo sapiens_hsa045400.86054164
60Glycerolipid metabolism_Homo sapiens_hsa005610.85286570
61Choline metabolism in cancer_Homo sapiens_hsa052310.84738384
62GnRH signaling pathway_Homo sapiens_hsa049120.83593711
63Linoleic acid metabolism_Homo sapiens_hsa005910.83449889
64Tyrosine metabolism_Homo sapiens_hsa003500.83119233
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82952063
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81958478
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81956174
68Cholinergic synapse_Homo sapiens_hsa047250.81657821
69Melanogenesis_Homo sapiens_hsa049160.80867109
70Long-term depression_Homo sapiens_hsa047300.80670060
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80444136
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80371625
73Notch signaling pathway_Homo sapiens_hsa043300.79486117
74mTOR signaling pathway_Homo sapiens_hsa041500.79029639
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78677412
76Oxytocin signaling pathway_Homo sapiens_hsa049210.77948130
77FoxO signaling pathway_Homo sapiens_hsa040680.77693802
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.77455835
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76890916
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75964792
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.75521185
82Cocaine addiction_Homo sapiens_hsa050300.75068549
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74909818
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72759133
85Insulin signaling pathway_Homo sapiens_hsa049100.72537574
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71272135
87Hepatitis C_Homo sapiens_hsa051600.71026541
88Tryptophan metabolism_Homo sapiens_hsa003800.70986618
89Taste transduction_Homo sapiens_hsa047420.69444351
90GABAergic synapse_Homo sapiens_hsa047270.69119963
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68856609
92Dopaminergic synapse_Homo sapiens_hsa047280.68189302
93Calcium signaling pathway_Homo sapiens_hsa040200.68171735
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67591015
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.66906611
96Alzheimers disease_Homo sapiens_hsa050100.66673161
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66339479
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66316353
99Acute myeloid leukemia_Homo sapiens_hsa052210.66023703
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65667654
101Oxidative phosphorylation_Homo sapiens_hsa001900.65178282
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64417335
103Lysine degradation_Homo sapiens_hsa003100.64217369
104Fatty acid metabolism_Homo sapiens_hsa012120.64087809
105ECM-receptor interaction_Homo sapiens_hsa045120.63855760
106Type II diabetes mellitus_Homo sapiens_hsa049300.62573004
107Amoebiasis_Homo sapiens_hsa051460.62235157
108Serotonergic synapse_Homo sapiens_hsa047260.61818406
109Glucagon signaling pathway_Homo sapiens_hsa049220.61588159
110Adherens junction_Homo sapiens_hsa045200.59911862
111Bladder cancer_Homo sapiens_hsa052190.59786109
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.59443210
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58945554
114Dorso-ventral axis formation_Homo sapiens_hsa043200.57955019
115Olfactory transduction_Homo sapiens_hsa047400.57674291
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57453787
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56907413
118Butanoate metabolism_Homo sapiens_hsa006500.56871550
119Histidine metabolism_Homo sapiens_hsa003400.56135879
120Hedgehog signaling pathway_Homo sapiens_hsa043400.54964834
121Endocytosis_Homo sapiens_hsa041440.54486292
122Glioma_Homo sapiens_hsa052140.54480996
123Lysosome_Homo sapiens_hsa041420.54270093
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53907722
125Focal adhesion_Homo sapiens_hsa045100.52985520
126Pertussis_Homo sapiens_hsa051330.52877028
127Morphine addiction_Homo sapiens_hsa050320.52784652
128Proteoglycans in cancer_Homo sapiens_hsa052050.52028514
129Arachidonic acid metabolism_Homo sapiens_hsa005900.51454302
130HIF-1 signaling pathway_Homo sapiens_hsa040660.51341917
131Sphingolipid metabolism_Homo sapiens_hsa006000.51281793
132Arginine biosynthesis_Homo sapiens_hsa002200.49870489
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49451705
134N-Glycan biosynthesis_Homo sapiens_hsa005100.49397348
135Chemical carcinogenesis_Homo sapiens_hsa052040.48841477
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47862367
137cAMP signaling pathway_Homo sapiens_hsa040240.47633790
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.46486111
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46263310
140Pancreatic cancer_Homo sapiens_hsa052120.45409665
141Renal cell carcinoma_Homo sapiens_hsa052110.45193131
142Chronic myeloid leukemia_Homo sapiens_hsa052200.44574233
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42606547
144Cardiac muscle contraction_Homo sapiens_hsa042600.41912355
145Hippo signaling pathway_Homo sapiens_hsa043900.41653966

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