TRRAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.55638093
2regulation of histone H3-K27 methylation (GO:0061085)4.30277846
3pre-miRNA processing (GO:0031054)4.28735749
4mitotic chromosome condensation (GO:0007076)4.10684841
5nuclear pore complex assembly (GO:0051292)4.01927361
6cytoplasmic mRNA processing body assembly (GO:0033962)3.98618601
7histone H3-K4 trimethylation (GO:0080182)3.71654367
8peptidyl-lysine dimethylation (GO:0018027)3.67437496
9positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.55852919
10nuclear pore organization (GO:0006999)3.50526908
11gonadal mesoderm development (GO:0007506)3.47814418
12regulation of NFAT protein import into nucleus (GO:0051532)3.44809684
13embryonic camera-type eye morphogenesis (GO:0048596)3.42221813
14DNA duplex unwinding (GO:0032508)3.33143496
15histone H3-K36 demethylation (GO:0070544)3.32480040
16histone H3-K4 methylation (GO:0051568)3.32257267
17establishment of nucleus localization (GO:0040023)3.27664928
18glucocorticoid receptor signaling pathway (GO:0042921)3.21191742
19NLS-bearing protein import into nucleus (GO:0006607)3.21112286
20mitotic sister chromatid cohesion (GO:0007064)3.20637953
21stress granule assembly (GO:0034063)3.16676099
22cell-substrate adherens junction assembly (GO:0007045)3.15560231
23focal adhesion assembly (GO:0048041)3.15560231
24DNA topological change (GO:0006265)3.13331563
25sister chromatid segregation (GO:0000819)3.13171583
26cellular response to epidermal growth factor stimulus (GO:0071364)3.10594306
27DNA geometric change (GO:0032392)3.10183649
28histone lysine methylation (GO:0034968)3.03641073
29mitotic sister chromatid segregation (GO:0000070)3.03264699
30negative regulation of cell size (GO:0045792)3.02840277
31negative regulation of histone methylation (GO:0031061)3.02129016
32histone H4-K16 acetylation (GO:0043984)3.01736999
33embryonic eye morphogenesis (GO:0048048)3.01097662
34histone H3-K9 demethylation (GO:0033169)2.99168500
35histone H4-K5 acetylation (GO:0043981)2.95559947
36histone H4-K8 acetylation (GO:0043982)2.95559947
37response to epidermal growth factor (GO:0070849)2.94206995
38negative regulation of translation, ncRNA-mediated (GO:0040033)2.94122247
39regulation of translation, ncRNA-mediated (GO:0045974)2.94122247
40negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.94122247
41V(D)J recombination (GO:0033151)2.93908982
42peptidyl-lysine trimethylation (GO:0018023)2.93758985
43negative regulation of erythrocyte differentiation (GO:0045647)2.93540429
44male sex determination (GO:0030238)2.93498229
45positive regulation of male gonad development (GO:2000020)2.91289490
46insulin-like growth factor receptor signaling pathway (GO:0048009)2.90775169
47protein export from nucleus (GO:0006611)2.89519306
48regulation of histone H3-K4 methylation (GO:0051569)2.88363715
49regulation of mammary gland epithelial cell proliferation (GO:0033599)2.87715184
50histone H3-K9 methylation (GO:0051567)2.87240715
51regulation of glucose import in response to insulin stimulus (GO:2001273)2.87108741
52pore complex assembly (GO:0046931)2.86377023
53regulation of protein polyubiquitination (GO:1902914)2.85355034
54regulation of histone methylation (GO:0031060)2.84012970
55embryonic process involved in female pregnancy (GO:0060136)2.82614284
56mitotic nuclear envelope disassembly (GO:0007077)2.82548217
57trophectodermal cell differentiation (GO:0001829)2.82410687
58regulation of RNA export from nucleus (GO:0046831)2.82196971
59heterochromatin organization (GO:0070828)2.80980461
60nuclear envelope disassembly (GO:0051081)2.79081977
61membrane disassembly (GO:0030397)2.79081977
62gene silencing by RNA (GO:0031047)2.78868836
63positive regulation of RNA splicing (GO:0033120)2.77853921
64synaptic vesicle docking involved in exocytosis (GO:0016081)2.77852115
65negative regulation of myotube differentiation (GO:0010832)2.77514467
66layer formation in cerebral cortex (GO:0021819)2.76846312
67glial cell proliferation (GO:0014009)2.76078490
68activation of Rac GTPase activity (GO:0032863)2.74257875
69DNA conformation change (GO:0071103)2.73482542
70sex determination (GO:0007530)2.72568633
71peptidyl-threonine phosphorylation (GO:0018107)2.70637103
72cell-substrate junction assembly (GO:0007044)2.70369870
73DNA replication initiation (GO:0006270)2.69654144
74gene silencing (GO:0016458)2.68806478
75apoptotic process involved in morphogenesis (GO:0060561)2.68786546
76regulation of meiosis I (GO:0060631)2.67955031
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.66654186
78positive regulation of gene expression, epigenetic (GO:0045815)2.66571118
79regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.64812709
80regulation of translational fidelity (GO:0006450)2.64184828
81peptidyl-threonine modification (GO:0018210)2.63817681
82regulation of short-term neuronal synaptic plasticity (GO:0048172)2.63394201
83positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.63217352
84protein localization to microtubule (GO:0035372)2.62243604
85peptidyl-lysine methylation (GO:0018022)2.61431317
86COPI coating of Golgi vesicle (GO:0048205)2.61300317
87Golgi transport vesicle coating (GO:0048200)2.61300317
88negative regulation of DNA repair (GO:0045738)2.61225520
89regulation of nucleobase-containing compound transport (GO:0032239)2.60869317
90epithelial cell differentiation involved in prostate gland development (GO:0060742)2.60468719
91chromosome condensation (GO:0030261)2.60087119
92positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.59177283
93corticosteroid receptor signaling pathway (GO:0031958)2.58828815
94histone H3-K9 modification (GO:0061647)2.58304310
95histone lysine demethylation (GO:0070076)2.58000323
96nucleus localization (GO:0051647)2.57937387
97cerebellar Purkinje cell differentiation (GO:0021702)2.56566060
983-UTR-mediated mRNA stabilization (GO:0070935)2.55496887
99histone methylation (GO:0016571)2.55228640
100positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.54250072
101nuclear envelope organization (GO:0006998)2.53795324
102DNA synthesis involved in DNA repair (GO:0000731)2.53411238
103regulation of chromatin binding (GO:0035561)2.51864066
104positive regulation of histone deacetylation (GO:0031065)2.51130854
105nucleosome disassembly (GO:0006337)2.47734025
106protein-DNA complex disassembly (GO:0032986)2.47734025
107positive regulation by host of viral transcription (GO:0043923)2.46699748
108locomotory exploration behavior (GO:0035641)2.46392092
109mannose metabolic process (GO:0006013)2.45512253
110regulation of sister chromatid cohesion (GO:0007063)2.45428396
111establishment of spindle localization (GO:0051293)2.45204350
112semaphorin-plexin signaling pathway (GO:0071526)2.43931590
113histone demethylation (GO:0016577)2.41889339
114histone H4-K12 acetylation (GO:0043983)2.41059059
115intracellular estrogen receptor signaling pathway (GO:0030520)2.38629071
116regulation of histone H3-K9 methylation (GO:0051570)2.36579677
117regulation of male gonad development (GO:2000018)2.36246239
118neural tube development (GO:0021915)2.35612456
119heart morphogenesis (GO:0003007)2.35276367
120RNA stabilization (GO:0043489)2.34264459
121mRNA stabilization (GO:0048255)2.34264459
122oocyte development (GO:0048599)2.33594483
123embryonic foregut morphogenesis (GO:0048617)2.32809822
124negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.31102198
125head development (GO:0060322)2.29551831
126chromatin silencing (GO:0006342)2.29028637
127hippo signaling (GO:0035329)2.26769922
128negative regulation of histone modification (GO:0031057)2.26752874
129regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.26399271
130dosage compensation (GO:0007549)2.26052694
131gastrulation with mouth forming second (GO:0001702)2.25672165
132planar cell polarity pathway involved in neural tube closure (GO:0090179)2.25652331
133ovulation cycle (GO:0042698)2.23970597
134sodium ion export (GO:0071436)2.23790161
135protein dealkylation (GO:0008214)2.23746367
136protein demethylation (GO:0006482)2.23746367
137positive regulation of dendrite morphogenesis (GO:0050775)2.23260739
138protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.21258561
139mRNA splice site selection (GO:0006376)2.20791236
140adherens junction assembly (GO:0034333)2.20685575
141positive regulation of synapse maturation (GO:0090129)2.19226349
142regulation of DNA damage checkpoint (GO:2000001)2.18821298
143anatomical structure regression (GO:0060033)2.18370323
144axon extension involved in axon guidance (GO:0048846)2.18288725
145neuron projection extension involved in neuron projection guidance (GO:1902284)2.18288725
146paraxial mesoderm development (GO:0048339)2.18202465
147spliceosomal tri-snRNP complex assembly (GO:0000244)2.17557952
148regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.17344410
149synaptonemal complex assembly (GO:0007130)2.16726233
150* histone H4 acetylation (GO:0043967)2.16525055
151macroautophagy (GO:0016236)2.15646935
152DNA alkylation (GO:0006305)2.14560471
153DNA methylation (GO:0006306)2.14560471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.69851982
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.05077121
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.04719781
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.04420316
5* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.99194949
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.93167183
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.92592065
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.63717758
9MYC_22102868_ChIP-Seq_BL_Human2.61842418
10DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.51225079
11ZFP281_27345836_Chip-Seq_ESCs_Mouse2.26298508
12KDM2B_26808549_Chip-Seq_DND41_Human2.21733459
13* TCF7_22412390_ChIP-Seq_EML_Mouse2.20485916
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.17825773
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.15683053
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.14988722
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.14810813
18DROSHA_22980978_ChIP-Seq_HELA_Human2.12364287
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10692979
20EZH2_22144423_ChIP-Seq_EOC_Human2.07985326
21TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.06462830
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.02783379
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00425220
24KDM2B_26808549_Chip-Seq_K562_Human1.97158839
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91169386
26KDM2B_26808549_Chip-Seq_JURKAT_Human1.90066564
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89791542
28* RARB_27405468_Chip-Seq_BRAIN_Mouse1.84734724
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.84596171
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78231199
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.77287987
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70515441
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67822103
34RACK7_27058665_Chip-Seq_MCF-7_Human1.66264778
35FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.65829476
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63345073
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62320317
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62221702
39AR_21909140_ChIP-Seq_LNCAP_Human1.61127564
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58882785
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57303760
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57107426
43PKCTHETA_26484144_Chip-Seq_BREAST_Human1.53037224
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52600921
45* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.51783784
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51543503
47ISL1_27105846_Chip-Seq_CPCs_Mouse1.49794861
48* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47613143
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41603893
50CLOCK_20551151_ChIP-Seq_293T_Human1.38561784
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37294973
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37002197
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.36647783
54VDR_21846776_ChIP-Seq_THP-1_Human1.35199597
55* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34307196
56VDR_24763502_ChIP-Seq_THP-1_Human1.33948302
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31003443
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29614635
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29146160
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26797505
61* CHD1_26751641_Chip-Seq_LNCaP_Human1.25529317
62ZNF263_19887448_ChIP-Seq_K562_Human1.24640712
63SCL_19346495_ChIP-Seq_HPC-7_Human1.24524058
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24006119
65* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22925112
66CIITA_25753668_ChIP-Seq_RAJI_Human1.22807811
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.22555185
68AR_19668381_ChIP-Seq_PC3_Human1.21730615
69AHR_22903824_ChIP-Seq_MCF-7_Human1.21000404
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20826357
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20272337
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20194780
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18608297
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18063476
75TP53_16413492_ChIP-PET_HCT116_Human1.17636125
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17567044
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14772002
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14531184
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14259637
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14040402
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13173503
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12950605
83CREB1_26743006_Chip-Seq_LNCaP_Human1.12164624
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.12050274
85* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11875278
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.11850220
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11424106
88MAF_26560356_Chip-Seq_TH2_Human1.11420148
89TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10331941
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10003944
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09553196
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09518264
93NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09441403
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09346711
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.08090638
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07158390
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06701694
98SPI1_23127762_ChIP-Seq_K562_Human1.06223263
99UTX_26944678_Chip-Seq_JUKART_Human1.05987380
100MYC_18555785_ChIP-Seq_MESCs_Mouse1.05084741
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.04733608
102RUNX1_27514584_Chip-Seq_MCF-7_Human1.03154572
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03091733
104ELK3_25401928_ChIP-Seq_HUVEC_Human1.02664361
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02216811
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.02098273
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00864728
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00421505
109MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98886541
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98868975
111RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97770101
112EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97770101
113FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97291703
114KDM5A_27292631_Chip-Seq_BREAST_Human0.96464807
115MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95241534
116* MYB_26560356_Chip-Seq_TH1_Human0.94949810
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94503950
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93770261
119ATF3_27146783_Chip-Seq_COLON_Human0.93491486
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.93443362
121NCOR1_26117541_ChIP-Seq_K562_Human0.93277653
122SMC4_20622854_ChIP-Seq_HELA_Human0.93032023
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92783715
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.92520281
125* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92234731
126* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90277357
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89428404
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89393048
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88384477
130SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88293646
131MAF_26560356_Chip-Seq_TH1_Human0.87646719
132STAT3_23295773_ChIP-Seq_U87_Human0.87570765
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.87332706
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87258992
135TCF4_18268006_ChIP-ChIP_LS174T_Human0.86890215
136RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86185824
137NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.86013897
138* TP53_22127205_ChIP-Seq_IMR90_Human0.85874290
139LXR_22292898_ChIP-Seq_THP-1_Human0.85054566
140SOX2_21211035_ChIP-Seq_LN229_Gbm0.84918450
141FOXA2_19822575_ChIP-Seq_HepG2_Human0.84513005
142E2F1_21310950_ChIP-Seq_MCF-7_Human0.84330561
143BRD4_25478319_ChIP-Seq_HGPS_Human0.82732581
144TP53_23651856_ChIP-Seq_MEFs_Mouse0.82573552
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.81466268
146FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81460529
147JARID2_20064375_ChIP-Seq_MESCs_Mouse0.79767959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.30537555
2MP0002009_preneoplasia3.46117855
3MP0005076_abnormal_cell_differentiation3.18636222
4MP0008877_abnormal_DNA_methylation3.01124446
5MP0003787_abnormal_imprinting2.84740858
6MP0004859_abnormal_synaptic_plasticity2.62671178
7MP0003121_genomic_imprinting2.39489203
8MP0009278_abnormal_bone_marrow2.21386784
9MP0004185_abnormal_adipocyte_glucose2.19156733
10MP0005409_darkened_coat_color2.18624825
11MP0003763_abnormal_thymus_physiology2.14085878
12MP0008995_early_reproductive_senescence2.08258307
13MP0002877_abnormal_melanocyte_morpholog2.00895753
14MP0008961_abnormal_basal_metabolism1.99688905
15MP0003705_abnormal_hypodermis_morpholog1.98590201
16MP0003045_fibrosis1.98259079
17MP0003123_paternal_imprinting1.94801967
18MP0005451_abnormal_body_composition1.83956842
19MP0003122_maternal_imprinting1.81847254
20MP0002166_altered_tumor_susceptibility1.80648768
21MP0010352_gastrointestinal_tract_polyps1.78415240
22MP0003283_abnormal_digestive_organ1.78150823
23MP0009780_abnormal_chondrocyte_physiolo1.75971076
24MP0005377_hearing/vestibular/ear_phenot1.74024403
25MP0003878_abnormal_ear_physiology1.74024403
26MP0005623_abnormal_meninges_morphology1.69542507
27MP0003300_gastrointestinal_ulcer1.64959804
28MP0003890_abnormal_embryonic-extraembry1.62936823
29MP0003115_abnormal_respiratory_system1.61677316
30MP0010307_abnormal_tumor_latency1.57953624
31MP0004264_abnormal_extraembryonic_tissu1.57074435
32MP0010234_abnormal_vibrissa_follicle1.53251135
33MP0003111_abnormal_nucleus_morphology1.51903803
34MP0004197_abnormal_fetal_growth/weight/1.51672941
35MP0000733_abnormal_muscle_development1.49157945
36MP0004808_abnormal_hematopoietic_stem1.46174543
37MP0004233_abnormal_muscle_weight1.46086229
38MP0000428_abnormal_craniofacial_morphol1.39290240
39MP0008438_abnormal_cutaneous_collagen1.36356075
40MP0001873_stomach_inflammation1.36022259
41MP0001348_abnormal_lacrimal_gland1.34431497
42MP0002084_abnormal_developmental_patter1.33616066
43MP0003693_abnormal_embryo_hatching1.32523711
44MP0005257_abnormal_intraocular_pressure1.29918334
45MP0000537_abnormal_urethra_morphology1.29583899
46MP0005621_abnormal_cell_physiology1.29022536
47MP0003453_abnormal_keratinocyte_physiol1.26960779
48MP0003935_abnormal_craniofacial_develop1.26860820
49MP0002653_abnormal_ependyma_morphology1.25779688
50MP0002249_abnormal_larynx_morphology1.23636546
51MP0003091_abnormal_cell_migration1.22994187
52MP0010030_abnormal_orbit_morphology1.22785402
53MP0008057_abnormal_DNA_replication1.22292185
54MP0010094_abnormal_chromosome_stability1.21393147
55MP0009703_decreased_birth_body1.20614334
56MP0002006_tumorigenesis1.19512908
57MP0004381_abnormal_hair_follicle1.18776111
58MP0003119_abnormal_digestive_system1.18747995
59* MP0004957_abnormal_blastocyst_morpholog1.18113304
60MP0003385_abnormal_body_wall1.17072954
61MP0004858_abnormal_nervous_system1.16625069
62MP0005666_abnormal_adipose_tissue1.16166572
63MP0003861_abnormal_nervous_system1.14258464
64MP0001661_extended_life_span1.10746345
65MP0005380_embryogenesis_phenotype1.08504011
66MP0001672_abnormal_embryogenesis/_devel1.08504011
67MP0003984_embryonic_growth_retardation1.07419578
68MP0000778_abnormal_nervous_system1.07416054
69* MP0002085_abnormal_embryonic_tissue1.07207798
70MP0000534_abnormal_ureter_morphology1.06982625
71MP0002088_abnormal_embryonic_growth/wei1.06042167
72MP0002925_abnormal_cardiovascular_devel1.04773415
73MP0000350_abnormal_cell_proliferation1.03314237
74MP0002396_abnormal_hematopoietic_system1.03086933
75MP0003566_abnormal_cell_adhesion1.02413097
76MP0001730_embryonic_growth_arrest1.02078596
77MP0003635_abnormal_synaptic_transmissio1.00967662
78MP0008932_abnormal_embryonic_tissue1.00779321
79* MP0002086_abnormal_extraembryonic_tissu1.00433049
80MP0002089_abnormal_postnatal_growth/wei1.00113609
81MP0003942_abnormal_urinary_system0.99296265
82MP0002796_impaired_skin_barrier0.98794480
83MP0002060_abnormal_skin_morphology0.97820754
84MP0005248_abnormal_Harderian_gland0.97294812
85MP0003077_abnormal_cell_cycle0.96334695
86MP0009672_abnormal_birth_weight0.96256201
87MP0004885_abnormal_endolymph0.93572647
88MP0002234_abnormal_pharynx_morphology0.92564329
89MP0001299_abnormal_eye_distance/0.92358035
90MP0002697_abnormal_eye_size0.92042222
91MP0005375_adipose_tissue_phenotype0.90397773
92MP0004811_abnormal_neuron_physiology0.90148404
93MP0001293_anophthalmia0.89683867
94MP0003943_abnormal_hepatobiliary_system0.88933594
95MP0001849_ear_inflammation0.88836218
96MP0002116_abnormal_craniofacial_bone0.88470137
97MP0002092_abnormal_eye_morphology0.88321330
98MP0005310_abnormal_salivary_gland0.87456827
99MP0005384_cellular_phenotype0.86847273
100MP0002210_abnormal_sex_determination0.86739408
101MP0004947_skin_inflammation0.86571052
102MP0000313_abnormal_cell_death0.86532771
103MP0001915_intracranial_hemorrhage0.85641009
104MP0000432_abnormal_head_morphology0.84709789
105MP0002063_abnormal_learning/memory/cond0.84044586
106MP0005187_abnormal_penis_morphology0.83766337
107MP0002152_abnormal_brain_morphology0.83329488
108MP0008260_abnormal_autophagy0.82304401
109MP0001697_abnormal_embryo_size0.82074237
110MP0005023_abnormal_wound_healing0.81856571
111MP0000371_diluted_coat_color0.80920096
112MP0003879_abnormal_hair_cell0.80368494
113MP0004272_abnormal_basement_membrane0.80100043
114MP0002081_perinatal_lethality0.78634147
115MP0008007_abnormal_cellular_replicative0.77871914
116MP0004134_abnormal_chest_morphology0.77341986
117MP0000266_abnormal_heart_morphology0.77085348
118MP0001958_emphysema0.77073581
119MP0000377_abnormal_hair_follicle0.76939795
120MP0002398_abnormal_bone_marrow0.76816828
121MP0004087_abnormal_muscle_fiber0.76164422
122MP0000003_abnormal_adipose_tissue0.76032782
123MP0005501_abnormal_skin_physiology0.75509891
124MP0006138_congestive_heart_failure0.74869632
125MP0002970_abnormal_white_adipose0.73953137
126MP0010630_abnormal_cardiac_muscle0.73828337
127MP0000767_abnormal_smooth_muscle0.73814551
128MP0000566_synostosis0.73167765
129MP0002098_abnormal_vibrissa_morphology0.72959423
130MP0002019_abnormal_tumor_incidence0.72746342
131MP0000751_myopathy0.72500620
132MP0000759_abnormal_skeletal_muscle0.72460864
133MP0001145_abnormal_male_reproductive0.72218564
134MP0002114_abnormal_axial_skeleton0.71514740
135MP0001784_abnormal_fluid_regulation0.70635621
136MP0005499_abnormal_olfactory_system0.70575420
137MP0005394_taste/olfaction_phenotype0.70575420
138MP0005397_hematopoietic_system_phenotyp0.70368654
139MP0001545_abnormal_hematopoietic_system0.70368654
140MP0003755_abnormal_palate_morphology0.70227641
141* MP0002080_prenatal_lethality0.69675598
142MP0002168_other_aberrant_phenotype0.69617848
143MP0002108_abnormal_muscle_morphology0.69380094
144MP0000490_abnormal_crypts_of0.69297008
145MP0001346_abnormal_lacrimal_gland0.68017740
146MP0000703_abnormal_thymus_morphology0.67448857
147MP0003786_premature_aging0.67398948
148MP0000955_abnormal_spinal_cord0.67174677

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.62513132
2Broad face (HP:0000283)3.39368694
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.33948330
4Short 4th metacarpal (HP:0010044)3.33948330
5Abnormality of the fingertips (HP:0001211)3.31280786
6Renovascular hypertension (HP:0100817)3.04594858
7Macroorchidism (HP:0000053)3.03977522
8Elfin facies (HP:0004428)3.03509331
9Abnormality of the distal phalanx of the thumb (HP:0009617)2.91159837
10Renal duplication (HP:0000075)2.83543013
11Cerebral aneurysm (HP:0004944)2.73438917
12Heterotopia (HP:0002282)2.71449541
13Abnormality of the astrocytes (HP:0100707)2.62383174
14Astrocytoma (HP:0009592)2.62383174
15Trigonocephaly (HP:0000243)2.60622259
16Urethral obstruction (HP:0000796)2.60082068
17Narrow palate (HP:0000189)2.56391308
18Pointed chin (HP:0000307)2.53663031
19Long eyelashes (HP:0000527)2.53180745
20Ulnar bowing (HP:0003031)2.53069611
21Overriding aorta (HP:0002623)2.52943910
22Abnormality of the lower motor neuron (HP:0002366)2.51982275
23Shallow orbits (HP:0000586)2.50200286
24Increased nuchal translucency (HP:0010880)2.46764766
25Obstructive sleep apnea (HP:0002870)2.42909798
26Flat acetabular roof (HP:0003180)2.42829111
27Insomnia (HP:0100785)2.42029886
28Obsessive-compulsive behavior (HP:0000722)2.41404957
29Asymmetry of the thorax (HP:0001555)2.41259163
30Abnormality of the 4th metacarpal (HP:0010012)2.40227898
31Flat cornea (HP:0007720)2.35746861
32Persistence of primary teeth (HP:0006335)2.29986401
33Ependymoma (HP:0002888)2.28442174
34Disproportionate tall stature (HP:0001519)2.28270718
35Bowel diverticulosis (HP:0005222)2.28045412
36Volvulus (HP:0002580)2.23554723
37Absent frontal sinuses (HP:0002688)2.19588897
38Bladder diverticulum (HP:0000015)2.16263155
39Glioma (HP:0009733)2.15144148
40Neonatal hypoglycemia (HP:0001998)2.06354763
41Neoplasm of the heart (HP:0100544)2.05232490
42Hand muscle atrophy (HP:0009130)2.03165075
43Upper limb amyotrophy (HP:0009129)2.02896739
44Distal upper limb amyotrophy (HP:0007149)2.02896739
45Protrusio acetabuli (HP:0003179)2.00389591
46Sparse lateral eyebrow (HP:0005338)1.99749311
47Abnormality of the diencephalon (HP:0010662)1.97899387
48Abnormality of the phalanges of the hallux (HP:0010057)1.95107754
49Broad thumb (HP:0011304)1.94934899
50High anterior hairline (HP:0009890)1.94815017
51Truncal obesity (HP:0001956)1.94369857
52Relative macrocephaly (HP:0004482)1.94311117
53Chromosomal breakage induced by crosslinking agents (HP:0003221)1.93410388
54Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.92084038
55Neoplasm of the oral cavity (HP:0100649)1.91702119
56Deviation of the thumb (HP:0009603)1.89681681
57Abnormality of the columella (HP:0009929)1.89654768
58Supernumerary ribs (HP:0005815)1.88824884
59Advanced eruption of teeth (HP:0006288)1.87348833
60Long palpebral fissure (HP:0000637)1.83860298
61Deep palmar crease (HP:0006191)1.83353342
62Dysmetric saccades (HP:0000641)1.82327241
63Chromsome breakage (HP:0040012)1.81466582
64Vertebral arch anomaly (HP:0008438)1.80460899
65Ectopic kidney (HP:0000086)1.79856778
66Prominent nose (HP:0000448)1.79002359
67Smooth philtrum (HP:0000319)1.78147851
68Dislocated radial head (HP:0003083)1.77938379
69Skull defect (HP:0001362)1.77640550
70Precocious puberty (HP:0000826)1.77631689
71Abnormality of the calcaneus (HP:0008364)1.77153532
72Broad palm (HP:0001169)1.76799027
73Osteolytic defects of the hand bones (HP:0009699)1.76113717
74Osteolytic defects of the phalanges of the hand (HP:0009771)1.76113717
75Arnold-Chiari malformation (HP:0002308)1.72733479
76Broad phalanges of the hand (HP:0009768)1.72342160
77Abnormality of the nasal septum (HP:0000419)1.72230698
78Subacute progressive viral hepatitis (HP:0006572)1.72204921
79Abnormality of the humeroradial joint (HP:0100744)1.72079726
80Sacral dimple (HP:0000960)1.72023182
81Genetic anticipation (HP:0003743)1.70900608
82Abnormality of chromosome segregation (HP:0002916)1.70520123
83Ankle contracture (HP:0006466)1.70457621
84Thick eyebrow (HP:0000574)1.69772689
85Midline defect of the nose (HP:0004122)1.69593441
86Distal lower limb amyotrophy (HP:0008944)1.68604446
87Proximal placement of thumb (HP:0009623)1.67795800
88Aneurysm (HP:0002617)1.66857651
89Abnormality of the radial head (HP:0003995)1.66544402
90Septate vagina (HP:0001153)1.65651835
91Broad finger (HP:0001500)1.65374477
92Colitis (HP:0002583)1.64925471
93Acute myeloid leukemia (HP:0004808)1.64336663
94Hypopigmentation of the fundus (HP:0007894)1.64227076
95Rectal prolapse (HP:0002035)1.63811821
96Megalocornea (HP:0000485)1.63195551
97Aortic aneurysm (HP:0004942)1.63187567
98Overgrowth (HP:0001548)1.62700943
99Anal stenosis (HP:0002025)1.62633614
100Medulloblastoma (HP:0002885)1.62475676
101Acute lymphatic leukemia (HP:0006721)1.61780273
102Lower limb amyotrophy (HP:0007210)1.61242931
103Mitral valve prolapse (HP:0001634)1.61235588
104Overlapping toe (HP:0001845)1.60895684
105Abnormality of the thoracic spine (HP:0100711)1.58991172
106Sandal gap (HP:0001852)1.58806002
107Premature skin wrinkling (HP:0100678)1.58773420
108Selective tooth agenesis (HP:0001592)1.58185872
109Spina bifida occulta (HP:0003298)1.58094987
110Turricephaly (HP:0000262)1.57973533
111Patellar dislocation (HP:0002999)1.57841261
112Cubitus valgus (HP:0002967)1.56580597
113Deep philtrum (HP:0002002)1.56526945
114Cafe-au-lait spot (HP:0000957)1.55988705
115Hypoplasia of the maxilla (HP:0000327)1.55731104
116Attention deficit hyperactivity disorder (HP:0007018)1.55596334
117Missing ribs (HP:0000921)1.55437711
118Spinal cord lesions (HP:0100561)1.55321099
119Syringomyelia (HP:0003396)1.55321099
120Pseudobulbar signs (HP:0002200)1.54893168
121Skin tags (HP:0010609)1.53934070
122Limited elbow extension (HP:0001377)1.53820079
123Spinal muscular atrophy (HP:0007269)1.53455848
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.53297254
125Supernumerary bones of the axial skeleton (HP:0009144)1.53145874
126Germ cell neoplasia (HP:0100728)1.52967857
127Enlarged penis (HP:0000040)1.52624293
128Aqueductal stenosis (HP:0002410)1.52522236
129Increased connective tissue (HP:0009025)1.52046954
130Broad phalanx (HP:0006009)1.51818726
131Abnormal ossification of hand bones (HP:0005921)1.51693379
132Urinary bladder sphincter dysfunction (HP:0002839)1.51683879
133Joint laxity (HP:0001388)1.51664037
134Lymphangioma (HP:0100764)1.51446610
135Annular pancreas (HP:0001734)1.51181494
136Self-mutilation (HP:0000742)1.51069755
137Ankyloglossia (HP:0010296)1.50428704
138Uterine leiomyosarcoma (HP:0002891)1.50316884
139Leiomyosarcoma (HP:0100243)1.50316884
140Termporal pattern (HP:0011008)1.49599991
141Insidious onset (HP:0003587)1.49599991
142Abnormality of the epiphyses of the hand (HP:0005924)1.48939119
143Abnormality of oral frenula (HP:0000190)1.48837380
144Gastrointestinal carcinoma (HP:0002672)1.47380412
145Malignant gastrointestinal tract tumors (HP:0006749)1.47380412
146Broad long bones (HP:0005622)1.46953742
147Low anterior hairline (HP:0000294)1.46501146
148Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.45911960
149Abnormality of the carotid arteries (HP:0005344)1.45510119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.31487367
2SMG13.67926516
3BRD43.06843011
4EEF2K2.73132603
5CAMK1G2.61040336
6TRIB32.47378400
7ICK2.35471249
8SIK22.35317211
9MAP3K102.31439293
10CAMK1D2.29544809
11FGFR42.14604254
12RIPK12.12450037
13TYRO31.91672970
14PKN21.89343936
15PRKD31.87364567
16LATS11.84577394
17NTRK31.67171170
18PDGFRA1.65672174
19SIK11.64719797
20MTOR1.60568439
21MAP3K41.60047923
22PTK61.44374645
23CDC71.42416231
24DAPK21.37289935
25SGK31.34951932
26TTN1.33380830
27ALK1.30349211
28CDK91.21531464
29RPS6KB21.19017518
30NEK21.18826484
31CDC42BPA1.17136836
32ERN11.14587801
33NTRK21.13945477
34MELK1.13150056
35IRAK31.12096074
36SGK21.09489585
37WNK11.05989809
38PDGFRB1.04374565
39MAP3K91.04180802
40DMPK1.02977281
41MARK21.00068987
42FGFR10.98837109
43MAPK110.98311278
44PRKCH0.97690404
45STK380.97202328
46FGFR30.96729842
47ATR0.96677176
48MAP3K70.95723907
49MAP3K130.93485045
50CDK40.92337319
51CDK60.91929464
52PNCK0.90459044
53CHEK10.90171599
54BMX0.88927213
55PAK60.88337870
56KSR10.87736292
57RET0.83861589
58EPHA40.82941211
59CAMKK10.81837377
60PTK20.81493275
61TAOK10.80466170
62FGFR20.79610125
63AKT30.79114152
64ERBB20.77466246
65RPS6KA20.77343739
66CAMK40.76223015
67DDR20.75913600
68SCYL20.73325648
69CDK80.73281828
70MST1R0.72706240
71ATM0.71554528
72MAP4K10.71141839
73HIPK20.70710338
74EPHA30.68435955
75CDK20.68138767
76SGK10.66204852
77PAK20.65501764
78MAP2K30.64423085
79PASK0.64255787
80GSK3B0.62625490
81PAK40.61975493
82MAPK80.61759718
83CDK70.61412851
84CHEK20.61288903
85STK30.61250110
86PRKDC0.60842814
87MARK10.60407733
88MAP3K140.60104455
89MAPK100.59700823
90SIK30.59583976
91MAPK140.58605099
92LATS20.58408974
93SGK2230.56538374
94SGK4940.56538374
95PRKD20.56384127
96MAP3K80.56288675
97CDK10.56110876
98PRPF4B0.56100090
99TTK0.56060346
100CHUK0.55657977
101RPS6KL10.55257137
102RPS6KC10.55257137
103CSNK1D0.54974449
104STK110.54934125
105DAPK10.54486820
106KSR20.52659551
107EPHA20.51090058
108NLK0.51051315
109CSNK1A1L0.50736838
110TRPM70.50093858
111HCK0.47383336
112MAPK10.47364309
113JAK10.44805396
114PTK2B0.44449447
115AKT10.44248305
116NEK90.43953056
117BTK0.43492623
118* RPS6KA30.42905393
119RPS6KB10.42010441
120CDK50.41346082
121CLK10.40743518
122CAMK10.40043857
123NEK60.39813463
124CSNK1E0.39742523
125MAP2K20.38977025
126MINK10.38400245
127RPS6KA60.37667633
128PDPK10.37446606
129TNK20.36732672
130MET0.36376721
131PRKAA10.35144261
132MAP3K20.34834571
133STK40.34577269
134IRAK20.34433085
135AURKB0.33431949

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052161.93682451
2Lysine degradation_Homo sapiens_hsa003101.80786970
3Dorso-ventral axis formation_Homo sapiens_hsa043201.57327247
4Thyroid hormone signaling pathway_Homo sapiens_hsa049191.54893458
5DNA replication_Homo sapiens_hsa030301.53443293
6Type II diabetes mellitus_Homo sapiens_hsa049301.52350292
7mTOR signaling pathway_Homo sapiens_hsa041501.51638876
8Chronic myeloid leukemia_Homo sapiens_hsa052201.45741114
9Notch signaling pathway_Homo sapiens_hsa043301.45012123
10Glioma_Homo sapiens_hsa052141.38557787
11Bladder cancer_Homo sapiens_hsa052191.37941814
12Endometrial cancer_Homo sapiens_hsa052131.36947151
13mRNA surveillance pathway_Homo sapiens_hsa030151.31479236
14Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28720047
15Long-term potentiation_Homo sapiens_hsa047201.25715076
16Non-small cell lung cancer_Homo sapiens_hsa052231.25087979
17Colorectal cancer_Homo sapiens_hsa052101.24150816
18MicroRNAs in cancer_Homo sapiens_hsa052061.23529696
19Hepatitis B_Homo sapiens_hsa051611.22248629
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.21588804
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21572321
22Basal cell carcinoma_Homo sapiens_hsa052171.18937269
23Adherens junction_Homo sapiens_hsa045201.18237540
24Axon guidance_Homo sapiens_hsa043601.17185366
25Circadian entrainment_Homo sapiens_hsa047131.17082079
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16985481
27Viral carcinogenesis_Homo sapiens_hsa052031.14159670
28Olfactory transduction_Homo sapiens_hsa047401.13331426
29Estrogen signaling pathway_Homo sapiens_hsa049151.12659667
30ErbB signaling pathway_Homo sapiens_hsa040121.12007984
31Small cell lung cancer_Homo sapiens_hsa052221.11493319
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10544561
33Proteoglycans in cancer_Homo sapiens_hsa052051.10071604
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09120435
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07756920
36Focal adhesion_Homo sapiens_hsa045101.06512759
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04893392
38Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03719883
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.00955875
40Oxytocin signaling pathway_Homo sapiens_hsa049211.00107461
41Hedgehog signaling pathway_Homo sapiens_hsa043400.99408678
42Hippo signaling pathway_Homo sapiens_hsa043900.99364716
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99319025
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98725807
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98241447
46Wnt signaling pathway_Homo sapiens_hsa043100.96818760
47Cholinergic synapse_Homo sapiens_hsa047250.96598346
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.96358815
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96238558
50cAMP signaling pathway_Homo sapiens_hsa040240.95991132
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95908145
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95525096
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95480974
54Pancreatic cancer_Homo sapiens_hsa052120.95350762
55Morphine addiction_Homo sapiens_hsa050320.94781693
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94753118
57Renin secretion_Homo sapiens_hsa049240.93359503
58Glutamatergic synapse_Homo sapiens_hsa047240.93331530
59Dopaminergic synapse_Homo sapiens_hsa047280.91938736
60Gastric acid secretion_Homo sapiens_hsa049710.91441092
61GnRH signaling pathway_Homo sapiens_hsa049120.91064378
62Insulin secretion_Homo sapiens_hsa049110.90057327
63Acute myeloid leukemia_Homo sapiens_hsa052210.89584875
64Salivary secretion_Homo sapiens_hsa049700.87980823
65Oocyte meiosis_Homo sapiens_hsa041140.87877809
66Dilated cardiomyopathy_Homo sapiens_hsa054140.87477263
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87448916
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86667596
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86551919
70Non-homologous end-joining_Homo sapiens_hsa034500.86486470
71Viral myocarditis_Homo sapiens_hsa054160.86160621
72* HTLV-I infection_Homo sapiens_hsa051660.85877300
73B cell receptor signaling pathway_Homo sapiens_hsa046620.85579864
74Melanogenesis_Homo sapiens_hsa049160.85415210
75Prostate cancer_Homo sapiens_hsa052150.85225217
76T cell receptor signaling pathway_Homo sapiens_hsa046600.84716997
77Renal cell carcinoma_Homo sapiens_hsa052110.84452443
78ECM-receptor interaction_Homo sapiens_hsa045120.83930152
79Inositol phosphate metabolism_Homo sapiens_hsa005620.83746534
80Hepatitis C_Homo sapiens_hsa051600.83512026
81Choline metabolism in cancer_Homo sapiens_hsa052310.83335024
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83260912
83Insulin resistance_Homo sapiens_hsa049310.82624425
84Nicotine addiction_Homo sapiens_hsa050330.82593621
85Gap junction_Homo sapiens_hsa045400.82559399
86VEGF signaling pathway_Homo sapiens_hsa043700.82290875
87Other glycan degradation_Homo sapiens_hsa005110.81879562
88Measles_Homo sapiens_hsa051620.81676498
89Rap1 signaling pathway_Homo sapiens_hsa040150.81621120
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81328676
91MAPK signaling pathway_Homo sapiens_hsa040100.81274883
92Prolactin signaling pathway_Homo sapiens_hsa049170.80988513
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80877943
94Apoptosis_Homo sapiens_hsa042100.80806032
95Insulin signaling pathway_Homo sapiens_hsa049100.80504895
96Amphetamine addiction_Homo sapiens_hsa050310.79698232
97Spliceosome_Homo sapiens_hsa030400.78385508
98Melanoma_Homo sapiens_hsa052180.77310319
99Pathways in cancer_Homo sapiens_hsa052000.76657212
100RNA transport_Homo sapiens_hsa030130.75507997
101TGF-beta signaling pathway_Homo sapiens_hsa043500.74265167
102HIF-1 signaling pathway_Homo sapiens_hsa040660.74203469
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74068487
104Synaptic vesicle cycle_Homo sapiens_hsa047210.74023363
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73847175
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73441980
107GABAergic synapse_Homo sapiens_hsa047270.73068557
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.72458074
109FoxO signaling pathway_Homo sapiens_hsa040680.72293234
110Platelet activation_Homo sapiens_hsa046110.71235252
111Amoebiasis_Homo sapiens_hsa051460.70910353
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70253987
113Cocaine addiction_Homo sapiens_hsa050300.70045029
114Influenza A_Homo sapiens_hsa051640.69434015
115Cell cycle_Homo sapiens_hsa041100.68835693
116Glucagon signaling pathway_Homo sapiens_hsa049220.68305858
117AMPK signaling pathway_Homo sapiens_hsa041520.67291802
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67144355
119Toxoplasmosis_Homo sapiens_hsa051450.66780215
120Chemokine signaling pathway_Homo sapiens_hsa040620.66606184
121Prion diseases_Homo sapiens_hsa050200.63163179
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.62482657
123Herpes simplex infection_Homo sapiens_hsa051680.62141036
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.61220196
125Epstein-Barr virus infection_Homo sapiens_hsa051690.60836237
126Pentose phosphate pathway_Homo sapiens_hsa000300.58762173
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.58673191
128Base excision repair_Homo sapiens_hsa034100.56845933
129Fatty acid biosynthesis_Homo sapiens_hsa000610.56627075
130TNF signaling pathway_Homo sapiens_hsa046680.53791684
131Thyroid hormone synthesis_Homo sapiens_hsa049180.52068257
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.51733701

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