TRUB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1startle response (GO:0001964)5.23861304
2DNA deamination (GO:0045006)5.01012598
3nuclear pore complex assembly (GO:0051292)4.92946578
4nuclear pore organization (GO:0006999)4.74080718
5mitotic sister chromatid cohesion (GO:0007064)4.64707916
6auditory behavior (GO:0031223)4.42732323
7ribosomal small subunit assembly (GO:0000028)4.29881749
8proteasome assembly (GO:0043248)4.06253788
9protein localization to kinetochore (GO:0034501)4.01442704
10ribosomal large subunit biogenesis (GO:0042273)3.99701639
11ribosome assembly (GO:0042255)3.93871871
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.88433373
13maturation of SSU-rRNA (GO:0030490)3.87889972
14protein localization to chromosome, centromeric region (GO:0071459)3.86812490
15regulation of mitochondrial translation (GO:0070129)3.80870425
16mechanosensory behavior (GO:0007638)3.78744452
17regulation of centriole replication (GO:0046599)3.73783668
18mitotic metaphase plate congression (GO:0007080)3.69495647
19sister chromatid segregation (GO:0000819)3.60876980
20tRNA methylation (GO:0030488)3.57609604
21nucleobase biosynthetic process (GO:0046112)3.54488397
22purine nucleobase biosynthetic process (GO:0009113)3.52866096
23negative regulation of DNA-dependent DNA replication (GO:2000104)3.50095209
24DNA unwinding involved in DNA replication (GO:0006268)3.49118866
25viral transcription (GO:0019083)3.49087990
26translational termination (GO:0006415)3.48374416
27mitotic sister chromatid segregation (GO:0000070)3.47652395
28spliceosomal complex assembly (GO:0000245)3.45708975
29establishment of integrated proviral latency (GO:0075713)3.44520224
30pore complex assembly (GO:0046931)3.40258939
31presynaptic membrane assembly (GO:0097105)3.39396539
32* pseudouridine synthesis (GO:0001522)3.37715932
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37200209
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37200209
35metaphase plate congression (GO:0051310)3.34463323
36double-strand break repair via nonhomologous end joining (GO:0006303)3.34363888
37non-recombinational repair (GO:0000726)3.34363888
38telomere maintenance via semi-conservative replication (GO:0032201)3.32909726
39protein complex biogenesis (GO:0070271)3.32479252
40mitochondrial respiratory chain complex assembly (GO:0033108)3.28936631
41ribosomal small subunit biogenesis (GO:0042274)3.28835269
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.28389073
43ribonucleoprotein complex biogenesis (GO:0022613)3.28378006
44DNA double-strand break processing (GO:0000729)3.26464647
45mitotic chromosome condensation (GO:0007076)3.14653574
46SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.11036545
47DNA replication initiation (GO:0006270)3.10997539
48maturation of 5.8S rRNA (GO:0000460)3.10959390
49cotranslational protein targeting to membrane (GO:0006613)3.10587387
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10103873
51cochlea development (GO:0090102)3.09195299
52presynaptic membrane organization (GO:0097090)3.09047796
53cellular component biogenesis (GO:0044085)3.08628051
54CENP-A containing nucleosome assembly (GO:0034080)3.07706896
55protein complex localization (GO:0031503)3.06835323
56transcription elongation from RNA polymerase I promoter (GO:0006362)3.06123759
57protein targeting to ER (GO:0045047)3.04805715
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02153361
59IMP biosynthetic process (GO:0006188)3.01699675
60ribosome biogenesis (GO:0042254)3.00189949
61regulation of nuclear cell cycle DNA replication (GO:0033262)2.99896149
62chromatin remodeling at centromere (GO:0031055)2.99402046
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98682860
64mitotic nuclear envelope disassembly (GO:0007077)2.98073903
65spliceosomal snRNP assembly (GO:0000387)2.96950496
66cellular protein complex localization (GO:0034629)2.95173277
67spindle checkpoint (GO:0031577)2.95052421
68rRNA modification (GO:0000154)2.94070056
69translational elongation (GO:0006414)2.93002413
70regulation of chromosome segregation (GO:0051983)2.92534373
71tRNA aminoacylation for protein translation (GO:0006418)2.92051910
72protein localization to endoplasmic reticulum (GO:0070972)2.91754428
73reflex (GO:0060004)2.91694497
74respiratory chain complex IV assembly (GO:0008535)2.90377103
75telomere maintenance via telomere lengthening (GO:0010833)2.89716974
76histone exchange (GO:0043486)2.89660186
77transcription elongation from RNA polymerase III promoter (GO:0006385)2.89411738
78termination of RNA polymerase III transcription (GO:0006386)2.89411738
79DNA strand elongation involved in DNA replication (GO:0006271)2.89388877
80mitochondrial respiratory chain complex I assembly (GO:0032981)2.89113896
81NADH dehydrogenase complex assembly (GO:0010257)2.89113896
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89113896
83tRNA aminoacylation (GO:0043039)2.89020620
84amino acid activation (GO:0043038)2.89020620
85organelle disassembly (GO:1903008)2.88102003
86cell morphogenesis involved in neuron differentiation (GO:0048667)2.87804703
87establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87690807
88establishment of chromosome localization (GO:0051303)2.87504716
89mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.87160592
90DNA-dependent DNA replication (GO:0006261)2.86536471
91metallo-sulfur cluster assembly (GO:0031163)2.86180178
92iron-sulfur cluster assembly (GO:0016226)2.86180178
93rRNA processing (GO:0006364)2.85527299
94mitotic spindle checkpoint (GO:0071174)2.84514679
95regulation of centrosome cycle (GO:0046605)2.84346591
96negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84306392
97negative regulation of mitotic sister chromatid separation (GO:2000816)2.84306392
98negative regulation of sister chromatid segregation (GO:0033046)2.84306392
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84306392
100negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84306392
101negative regulation of chromosome segregation (GO:0051985)2.83777485
102DNA replication checkpoint (GO:0000076)2.83472966
103positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.82955960
104cytochrome complex assembly (GO:0017004)2.82562363
105ribonucleoprotein complex disassembly (GO:0032988)2.82356917
106DNA damage response, detection of DNA damage (GO:0042769)2.82225797
107mannosylation (GO:0097502)2.81712684
108DNA replication-independent nucleosome assembly (GO:0006336)2.81697513
109DNA replication-independent nucleosome organization (GO:0034724)2.81697513
110response to auditory stimulus (GO:0010996)2.81617340
111regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.81196516
112nuclear envelope disassembly (GO:0051081)2.81096155
113membrane disassembly (GO:0030397)2.81096155
114formation of translation preinitiation complex (GO:0001731)2.80731116
115telomere maintenance via recombination (GO:0000722)2.80522152
116innervation (GO:0060384)2.79640302
117regulation of coenzyme metabolic process (GO:0051196)2.78619355
118regulation of cofactor metabolic process (GO:0051193)2.78619355
119kinetochore assembly (GO:0051382)2.78410489
120positive regulation of chromosome segregation (GO:0051984)2.78407313
121telomere maintenance via telomerase (GO:0007004)2.77733112
122DNA strand elongation (GO:0022616)2.76588131
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.76023199
124regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76023199
125viral mRNA export from host cell nucleus (GO:0046784)2.75919230
126tRNA modification (GO:0006400)2.75572802
127regulation of centrosome duplication (GO:0010824)2.74379282
128cellular protein complex disassembly (GO:0043624)2.74371168
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.73683056
130rRNA metabolic process (GO:0016072)2.73350024
131attachment of spindle microtubules to kinetochore (GO:0008608)2.72973082
132DNA ligation (GO:0006266)2.72158564
133* tRNA processing (GO:0008033)2.72039647
134regulation of sister chromatid cohesion (GO:0007063)2.71726109
135regulation of sister chromatid segregation (GO:0033045)2.71050348
136regulation of mitotic sister chromatid separation (GO:0010965)2.71050348
137regulation of mitotic sister chromatid segregation (GO:0033047)2.71050348
138termination of RNA polymerase I transcription (GO:0006363)2.70529483
139nonmotile primary cilium assembly (GO:0035058)2.70477951
140hindbrain development (GO:0030902)2.69910330
141pyrimidine dimer repair (GO:0006290)2.69242612
142regulation of helicase activity (GO:0051095)2.68895690
143regulation of DNA endoreduplication (GO:0032875)2.68701903
144IMP metabolic process (GO:0046040)2.67648618
145paraxial mesoderm development (GO:0048339)2.67624323
146mitotic spindle organization (GO:0007052)2.67510789
147mitotic spindle assembly checkpoint (GO:0007094)2.66022566
148rRNA methylation (GO:0031167)2.65308756
149spindle assembly checkpoint (GO:0071173)2.64867594
150* tRNA metabolic process (GO:0006399)2.64691195
151RNA methylation (GO:0001510)2.64406950
152regulation of mitotic spindle organization (GO:0060236)2.64318175
153RNA-dependent DNA replication (GO:0006278)2.63996372
154establishment of viral latency (GO:0019043)2.63928658
155cullin deneddylation (GO:0010388)2.63832828
156viral life cycle (GO:0019058)2.62370670
157regulation of spindle organization (GO:0090224)2.62255411
158energy coupled proton transport, down electrochemical gradient (GO:0015985)2.62224986
159ATP synthesis coupled proton transport (GO:0015986)2.62224986
160nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.61567855
161cranial nerve development (GO:0021545)2.59763295
162RNA capping (GO:0036260)2.59049999
1637-methylguanosine RNA capping (GO:0009452)2.59049999
164intra-S DNA damage checkpoint (GO:0031573)2.58558539
165mitochondrial DNA replication (GO:0006264)2.58396320
166regulation of translational fidelity (GO:0006450)2.58325543
167response to X-ray (GO:0010165)2.58230570
168positive regulation of dendritic spine morphogenesis (GO:0061003)2.57995383
169kinetochore organization (GO:0051383)2.56939938
170protein localization to chromosome (GO:0034502)2.55844944
171sister chromatid cohesion (GO:0007062)2.55836671
172DNA duplex unwinding (GO:0032508)2.53156683
173DNA replication-dependent nucleosome organization (GO:0034723)2.50935847
174DNA replication-dependent nucleosome assembly (GO:0006335)2.50935847
175DNA geometric change (GO:0032392)2.50923841
176mitotic recombination (GO:0006312)2.50592258
177ATP-dependent chromatin remodeling (GO:0043044)2.49973929
178regulation of acyl-CoA biosynthetic process (GO:0050812)2.48484444
179folic acid-containing compound biosynthetic process (GO:0009396)2.47621217
180L-serine metabolic process (GO:0006563)2.46846873
181positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.45828001
182positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.45828001
183positive regulation of mitotic sister chromatid separation (GO:1901970)2.45828001
184protein K6-linked ubiquitination (GO:0085020)2.45015645
185regulation of translational elongation (GO:0006448)2.44711666
186transcription from mitochondrial promoter (GO:0006390)2.43542064
187chromosome segregation (GO:0007059)2.39346819

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.37133412
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.41588019
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.35830296
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.24040699
5AR_21909140_ChIP-Seq_LNCAP_Human3.08409540
6GBX2_23144817_ChIP-Seq_PC3_Human3.07213007
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.96667952
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84614421
9EZH2_22144423_ChIP-Seq_EOC_Human2.84076020
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67049789
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64857078
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63266659
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59336740
14* EST1_17652178_ChIP-ChIP_JURKAT_Human2.48589286
15* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47977540
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.39340720
17IRF1_19129219_ChIP-ChIP_H3396_Human2.35366222
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.31464202
19* ETS1_20019798_ChIP-Seq_JURKAT_Human2.26572738
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.23549381
21TAF15_26573619_Chip-Seq_HEK293_Human2.22537243
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22434038
23FUS_26573619_Chip-Seq_HEK293_Human2.18730419
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11491059
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07967253
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04364191
27* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99572577
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99033827
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98373568
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98114464
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93138841
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91917789
33* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91212122
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.91059735
35EWS_26573619_Chip-Seq_HEK293_Human1.88569674
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86152847
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85366707
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82760464
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73808679
40* VDR_23849224_ChIP-Seq_CD4+_Human1.71641477
41FOXP3_21729870_ChIP-Seq_TREG_Human1.71292958
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66731263
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65368742
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62548926
45IGF1R_20145208_ChIP-Seq_DFB_Human1.61105460
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.61025293
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59673928
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.58347042
49* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55205974
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52829410
51TTF2_22483619_ChIP-Seq_HELA_Human1.51639728
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51225173
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48847739
54CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48299812
55* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48081675
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.47975643
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44082363
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42670433
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.40852037
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.39826281
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39083021
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39072139
63P300_19829295_ChIP-Seq_ESCs_Human1.36389920
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36239604
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36000501
66* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34500672
67MYC_18940864_ChIP-ChIP_HL60_Human1.32688549
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31726406
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30188657
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29436585
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28320011
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.27045486
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25831965
74SOX17_20123909_ChIP-Seq_XEN_Mouse1.24863032
75REST_21632747_ChIP-Seq_MESCs_Mouse1.24410004
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23233621
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22956322
78XRN2_22483619_ChIP-Seq_HELA_Human1.22115750
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.21567058
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19739100
81RNF2_27304074_Chip-Seq_NSC_Mouse1.19371332
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.18328699
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17224480
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16277567
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16082472
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.15466669
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13695750
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.13579783
89* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13356081
90DCP1A_22483619_ChIP-Seq_HELA_Human1.12318060
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11550562
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11522077
93NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10579415
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10339024
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09832320
96TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07978454
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07976035
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06822404
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.06450268
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05689528
101SOX2_16153702_ChIP-ChIP_HESCs_Human1.04780796
102SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04588014
103ELK1_19687146_ChIP-ChIP_HELA_Human1.04084320
104* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03248247
105PIAS1_25552417_ChIP-Seq_VCAP_Human1.02870210
106ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01892090
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.00069701
108* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99407773
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99338187
110JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99092557
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98742139
112NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96931841
113SOX9_26525672_Chip-Seq_HEART_Mouse0.96135876
114GABP_19822575_ChIP-Seq_HepG2_Human0.95852977
115WT1_19549856_ChIP-ChIP_CCG9911_Human0.95648801
116CHD1_26751641_Chip-Seq_LNCaP_Human0.95036440
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93319495
118* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93214640
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.93104351
120E2F1_18555785_Chip-Seq_ESCs_Mouse0.92991313
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92934983
122* KDM5A_27292631_Chip-Seq_BREAST_Human0.92928829
123REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92625440
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.92030904
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91837790
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91438120
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91377680
128P53_22387025_ChIP-Seq_ESCs_Mouse0.90875108
129SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90101394
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89927288
131RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89348218
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89259442
133E2F1_21310950_ChIP-Seq_MCF-7_Human0.88512777
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87989988
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86007190
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85466711
137TFEB_21752829_ChIP-Seq_HELA_Human0.84671453
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84625439
139NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84550148
140* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84542793
141NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84053070
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82014788
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80288176
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80207314
145* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80083964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.92554374
2MP0006292_abnormal_olfactory_placode3.22317363
3MP0002736_abnormal_nociception_after3.07274699
4MP0003880_abnormal_central_pattern3.04229123
5MP0000566_synostosis2.95818767
6MP0001968_abnormal_touch/_nociception2.78522508
7MP0009379_abnormal_foot_pigmentation2.59708079
8MP0010234_abnormal_vibrissa_follicle2.20737514
9MP0003111_abnormal_nucleus_morphology2.18707418
10MP0004859_abnormal_synaptic_plasticity2.13684354
11MP0010352_gastrointestinal_tract_polyps2.13355474
12MP0008058_abnormal_DNA_repair2.08283825
13MP0003787_abnormal_imprinting2.04830742
14MP0003123_paternal_imprinting2.02504548
15MP0008007_abnormal_cellular_replicative2.01694395
16MP0003121_genomic_imprinting2.00978082
17MP0003136_yellow_coat_color1.99109610
18MP0010094_abnormal_chromosome_stability1.98030635
19MP0003635_abnormal_synaptic_transmissio1.95340694
20MP0003693_abnormal_embryo_hatching1.95107630
21MP0004957_abnormal_blastocyst_morpholog1.91636302
22MP0009745_abnormal_behavioral_response1.90854162
23MP0003806_abnormal_nucleotide_metabolis1.89914291
24MP0002572_abnormal_emotion/affect_behav1.79299782
25MP0002938_white_spotting1.76550988
26MP0005075_abnormal_melanosome_morpholog1.75814611
27MP0001730_embryonic_growth_arrest1.74091350
28MP0005646_abnormal_pituitary_gland1.70345716
29MP0005423_abnormal_somatic_nervous1.67449855
30MP0004142_abnormal_muscle_tone1.67187093
31MP0003937_abnormal_limbs/digits/tail_de1.66088202
32MP0001486_abnormal_startle_reflex1.64474429
33MP0009046_muscle_twitch1.62753833
34MP0004381_abnormal_hair_follicle1.62099491
35MP0008877_abnormal_DNA_methylation1.58619854
36MP0002272_abnormal_nervous_system1.57764749
37MP0009697_abnormal_copulation1.54492447
38MP0002735_abnormal_chemical_nociception1.54200843
39MP0002084_abnormal_developmental_patter1.52758186
40MP0002063_abnormal_learning/memory/cond1.52461470
41MP0001529_abnormal_vocalization1.51998287
42MP0002064_seizures1.51232003
43MP0002067_abnormal_sensory_capabilities1.50944464
44MP0000350_abnormal_cell_proliferation1.50772380
45MP0002102_abnormal_ear_morphology1.48542214
46MP0001293_anophthalmia1.47984088
47MP0001502_abnormal_circadian_rhythm1.47480351
48MP0005409_darkened_coat_color1.47236900
49MP0000537_abnormal_urethra_morphology1.46744872
50MP0001501_abnormal_sleep_pattern1.45457710
51MP0002557_abnormal_social/conspecific_i1.43701124
52MP0001672_abnormal_embryogenesis/_devel1.43540887
53MP0005380_embryogenesis_phenotype1.43540887
54MP0002697_abnormal_eye_size1.41574789
55MP0003221_abnormal_cardiomyocyte_apopto1.40469085
56MP0003122_maternal_imprinting1.38091622
57MP0006072_abnormal_retinal_apoptosis1.37945859
58MP0001986_abnormal_taste_sensitivity1.36190550
59MP0002184_abnormal_innervation1.35852671
60MP0001697_abnormal_embryo_size1.34972045
61MP0001905_abnormal_dopamine_level1.34798246
62MP0002877_abnormal_melanocyte_morpholog1.34060612
63MP0003890_abnormal_embryonic-extraembry1.33476522
64MP0002085_abnormal_embryonic_tissue1.32745424
65MP0008057_abnormal_DNA_replication1.32214714
66MP0002233_abnormal_nose_morphology1.30506545
67MP0005379_endocrine/exocrine_gland_phen1.29900925
68MP0004197_abnormal_fetal_growth/weight/1.28419171
69MP0006035_abnormal_mitochondrial_morpho1.28243264
70MP0003119_abnormal_digestive_system1.25498103
71MP0003984_embryonic_growth_retardation1.24490169
72MP0000026_abnormal_inner_ear1.22403831
73MP0008932_abnormal_embryonic_tissue1.22118811
74MP0009672_abnormal_birth_weight1.21256191
75MP0002088_abnormal_embryonic_growth/wei1.20925884
76MP0006276_abnormal_autonomic_nervous1.20566377
77MP0003718_maternal_effect1.19692187
78MP0002822_catalepsy1.19151429
79MP0002733_abnormal_thermal_nociception1.16618877
80MP0001299_abnormal_eye_distance/1.15974946
81MP0003283_abnormal_digestive_organ1.15695050
82MP0002080_prenatal_lethality1.15339328
83MP0003077_abnormal_cell_cycle1.14855957
84MP0010307_abnormal_tumor_latency1.14761611
85MP0000631_abnormal_neuroendocrine_gland1.14005623
86MP0005551_abnormal_eye_electrophysiolog1.13971829
87MP0002734_abnormal_mechanical_nocicepti1.13852097
88MP0003385_abnormal_body_wall1.08929628
89MP0001286_abnormal_eye_development1.08498591
90MP0004924_abnormal_behavior1.07439224
91MP0005386_behavior/neurological_phenoty1.07439224
92MP0000778_abnormal_nervous_system1.07348685
93MP0001661_extended_life_span1.06920717
94MP0003941_abnormal_skin_development1.06805327
95MP0002009_preneoplasia1.05890976
96MP0009703_decreased_birth_body1.04702039
97MP0004133_heterotaxia1.04508666
98MP0003786_premature_aging1.04343690
99MP0002234_abnormal_pharynx_morphology1.03867998
100MP0001963_abnormal_hearing_physiology1.02595333
101MP0005645_abnormal_hypothalamus_physiol1.02102163
102MP0002095_abnormal_skin_pigmentation1.01292884
103MP0004233_abnormal_muscle_weight0.97332500
104MP0005623_abnormal_meninges_morphology0.97078141
105MP0001177_atelectasis0.96397210
106MP0002092_abnormal_eye_morphology0.96226079
107MP0001970_abnormal_pain_threshold0.95335222
108MP0003938_abnormal_ear_development0.93804272
109MP0002638_abnormal_pupillary_reflex0.93764923
110MP0005394_taste/olfaction_phenotype0.93528606
111MP0005499_abnormal_olfactory_system0.93528606
112MP0002086_abnormal_extraembryonic_tissu0.92244150
113MP0000358_abnormal_cell_content/0.92152577
114MP0003315_abnormal_perineum_morphology0.92028104
115MP0010678_abnormal_skin_adnexa0.91299204
116MP0005253_abnormal_eye_physiology0.91070588
117MP0005248_abnormal_Harderian_gland0.90590079
118MP0002752_abnormal_somatic_nervous0.90273135
119MP0008789_abnormal_olfactory_epithelium0.90086398
120MP0002269_muscular_atrophy0.89757425
121MP0002111_abnormal_tail_morphology0.89021803
122MP0000462_abnormal_digestive_system0.88618394
123MP0003943_abnormal_hepatobiliary_system0.87814897
124MP0003942_abnormal_urinary_system0.87725715
125MP0001984_abnormal_olfaction0.86788768
126MP0005220_abnormal_exocrine_pancreas0.86428293
127MP0003567_abnormal_fetal_cardiomyocyte0.86164781
128MP0003861_abnormal_nervous_system0.86014920
129MP0003755_abnormal_palate_morphology0.85772801
130MP0004215_abnormal_myocardial_fiber0.84606631
131MP0001485_abnormal_pinna_reflex0.84527419
132MP0004147_increased_porphyrin_level0.84434141
133MP0001346_abnormal_lacrimal_gland0.84161618
134MP0003935_abnormal_craniofacial_develop0.83562521
135MP0002210_abnormal_sex_determination0.83141033
136MP0001440_abnormal_grooming_behavior0.82890394
137MP0002160_abnormal_reproductive_system0.82843829
138MP0000647_abnormal_sebaceous_gland0.81420058
139MP0001340_abnormal_eyelid_morphology0.81274122
140MP0001145_abnormal_male_reproductive0.79840363
141MP0005391_vision/eye_phenotype0.79582331
142MP0000372_irregular_coat_pigmentation0.79414929
143MP0001929_abnormal_gametogenesis0.78534989
144MP0000579_abnormal_nail_morphology0.76944865
145MP0004185_abnormal_adipocyte_glucose0.76407259
146MP0010030_abnormal_orbit_morphology0.76280012
147MP0000955_abnormal_spinal_cord0.76220349
148MP0000762_abnormal_tongue_morphology0.75274212
149MP0000383_abnormal_hair_follicle0.75131887
150MP0004272_abnormal_basement_membrane0.74429950
151MP0009780_abnormal_chondrocyte_physiolo0.74292252
152MP0002882_abnormal_neuron_morphology0.73573668
153MP0005187_abnormal_penis_morphology0.73237307
154MP0000428_abnormal_craniofacial_morphol0.73177621
155MP0004270_analgesia0.72854149
156MP0005408_hypopigmentation0.72824124
157MP0000049_abnormal_middle_ear0.72757612
158MP0000653_abnormal_sex_gland0.72328791
159MP0002751_abnormal_autonomic_nervous0.72012901
160MP0000432_abnormal_head_morphology0.71175691
161MP0010386_abnormal_urinary_bladder0.71017738
162MP0002066_abnormal_motor_capabilities/c0.69977555
163MP0002177_abnormal_outer_ear0.69887839
164MP0001915_intracranial_hemorrhage0.69126312
165MP0000313_abnormal_cell_death0.68225217

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.94275302
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.36640917
3Papillary thyroid carcinoma (HP:0002895)3.01541126
4Birth length less than 3rd percentile (HP:0003561)3.00229331
5Focal motor seizures (HP:0011153)2.98217821
6Abnormality of cells of the erythroid lineage (HP:0012130)2.97802958
7Chromsome breakage (HP:0040012)2.96559996
8Abnormal number of erythroid precursors (HP:0012131)2.81425684
9Meckel diverticulum (HP:0002245)2.78693498
10Abnormality of the preputium (HP:0100587)2.78508486
11Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78419327
12Duplicated collecting system (HP:0000081)2.77891179
13Abnormality of the ileum (HP:0001549)2.76626548
14Absent radius (HP:0003974)2.76216999
15Volvulus (HP:0002580)2.75656695
16Acute necrotizing encephalopathy (HP:0006965)2.71203708
17Mitochondrial inheritance (HP:0001427)2.67577407
18True hermaphroditism (HP:0010459)2.66216565
19Increased hepatocellular lipid droplets (HP:0006565)2.65830910
20Abnormal mitochondria in muscle tissue (HP:0008316)2.65597791
21Supernumerary spleens (HP:0009799)2.62239669
22Increased nuchal translucency (HP:0010880)2.61832482
23Absent forearm bone (HP:0003953)2.58461133
24Aplasia involving forearm bones (HP:0009822)2.58461133
25Increased CSF lactate (HP:0002490)2.53383552
26Abnormality of chromosome stability (HP:0003220)2.52599859
27Abnormal lung lobation (HP:0002101)2.50463386
28Pancreatic fibrosis (HP:0100732)2.49215892
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46265125
30Aplastic anemia (HP:0001915)2.43843662
31Abnormality of the renal collecting system (HP:0004742)2.42819552
32Asplenia (HP:0001746)2.41859038
33Thyroid carcinoma (HP:0002890)2.40621287
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.40160305
35Congenital primary aphakia (HP:0007707)2.39902671
36Hepatocellular necrosis (HP:0001404)2.37056481
37Gait imbalance (HP:0002141)2.36041646
38Nephroblastoma (Wilms tumor) (HP:0002667)2.33126828
39Abnormal hair whorl (HP:0010721)2.32156235
40Type 2 muscle fiber atrophy (HP:0003554)2.31910319
41Macrocytic anemia (HP:0001972)2.30977781
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30326298
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30326298
44Abnormality of the labia minora (HP:0012880)2.30271786
45Absent thumb (HP:0009777)2.29917222
46Medulloblastoma (HP:0002885)2.29489715
47Pancreatic cysts (HP:0001737)2.29037717
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28488442
49Progressive macrocephaly (HP:0004481)2.27676622
50Medial flaring of the eyebrow (HP:0010747)2.27165546
51Protruding tongue (HP:0010808)2.27082697
52Abnormality of glycolysis (HP:0004366)2.26885256
53Microvesicular hepatic steatosis (HP:0001414)2.26391402
54Neoplasm of the adrenal gland (HP:0100631)2.25959760
55Type I transferrin isoform profile (HP:0003642)2.25822101
56Cortical dysplasia (HP:0002539)2.25197231
57Lipid accumulation in hepatocytes (HP:0006561)2.24651575
58Febrile seizures (HP:0002373)2.23263964
59Acute encephalopathy (HP:0006846)2.22429795
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22343903
613-Methylglutaconic aciduria (HP:0003535)2.19879882
62Hypoglycemic seizures (HP:0002173)2.19364454
63Facial cleft (HP:0002006)2.19323101
64Nephrogenic diabetes insipidus (HP:0009806)2.18425075
65Increased serum pyruvate (HP:0003542)2.17023827
66Increased serum lactate (HP:0002151)2.16470787
67Neoplasm of the adrenal cortex (HP:0100641)2.12136991
68Embryonal renal neoplasm (HP:0011794)2.11814483
69Hyperventilation (HP:0002883)2.11291793
70Acute lymphatic leukemia (HP:0006721)2.10698272
71Severe Myopia (HP:0011003)2.09347814
72Duplication of thumb phalanx (HP:0009942)2.09108057
73Pancytopenia (HP:0001876)2.08973588
74Hyperinsulinemic hypoglycemia (HP:0000825)2.08723950
75Pallor (HP:0000980)2.08380108
76Congenital sensorineural hearing impairment (HP:0008527)2.08235078
77Abnormality of the columella (HP:0009929)2.07902706
78Triphalangeal thumb (HP:0001199)2.07609300
79Abnormality of the fetal cardiovascular system (HP:0010948)2.07396766
80Abnormal umbilical cord blood vessels (HP:0011403)2.07396766
81Single umbilical artery (HP:0001195)2.07396766
82Aplasia/Hypoplasia of the spleen (HP:0010451)2.05960428
83Horseshoe kidney (HP:0000085)2.04548680
84Biliary tract neoplasm (HP:0100574)2.03404631
85Neoplasm of the colon (HP:0100273)2.03343722
86White forelock (HP:0002211)2.01918629
87Increased intramyocellular lipid droplets (HP:0012240)2.01255385
88Decreased central vision (HP:0007663)2.00341390
89Patchy hypopigmentation of hair (HP:0011365)1.96997902
90Gastroesophageal reflux (HP:0002020)1.95219225
91Pheochromocytoma (HP:0002666)1.95197132
92Aplasia cutis congenita (HP:0001057)1.95057921
93Molar tooth sign on MRI (HP:0002419)1.94670143
94Abnormality of midbrain morphology (HP:0002418)1.94670143
95Poor suck (HP:0002033)1.93921546
96Progressive external ophthalmoplegia (HP:0000590)1.92511246
97Multiple enchondromatosis (HP:0005701)1.91779247
98Hepatic necrosis (HP:0002605)1.91229969
99Overlapping toe (HP:0001845)1.90953719
100Aplasia/hypoplasia of the uterus (HP:0008684)1.90278055
101Chronic hepatic failure (HP:0100626)1.89964771
102Termporal pattern (HP:0011008)1.89596495
103Insidious onset (HP:0003587)1.89596495
104Ependymoma (HP:0002888)1.88881532
105Cerebral hypomyelination (HP:0006808)1.88407038
106Genital tract atresia (HP:0001827)1.87869271
107Occipital encephalocele (HP:0002085)1.87784718
108Optic nerve hypoplasia (HP:0000609)1.87512721
109Absent eyebrow (HP:0002223)1.86194609
110Rhabdomyosarcoma (HP:0002859)1.86162180
111Colon cancer (HP:0003003)1.86144404
112Renal Fanconi syndrome (HP:0001994)1.85712828
113Fair hair (HP:0002286)1.85205307
114Vaginal atresia (HP:0000148)1.84569069
115Ovarian neoplasm (HP:0100615)1.84064678
116Prominent metopic ridge (HP:0005487)1.83847803
117Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83296231
118Hypoglycemic coma (HP:0001325)1.82616450
119Neoplasm of the peripheral nervous system (HP:0100007)1.81687853
120Atonic seizures (HP:0010819)1.80552786
121Neuroendocrine neoplasm (HP:0100634)1.80474693
122Myelodysplasia (HP:0002863)1.79549352
123Proximal placement of thumb (HP:0009623)1.79094540
124Horizontal nystagmus (HP:0000666)1.79011767
125Lactic acidosis (HP:0003128)1.77641284
126Shoulder girdle muscle weakness (HP:0003547)1.77591083
127Glioma (HP:0009733)1.77584863
128Neoplasm of the small intestine (HP:0100833)1.77290999
129Microglossia (HP:0000171)1.77181034
130Gonadotropin excess (HP:0000837)1.77040601
131Deviation of the thumb (HP:0009603)1.76528258
132Abnormality of the astrocytes (HP:0100707)1.76466998
133Astrocytoma (HP:0009592)1.76466998
134Muscle fiber atrophy (HP:0100295)1.75996581
135Abnormality of pyrimidine metabolism (HP:0004353)1.75910565
136Duodenal stenosis (HP:0100867)1.75535105
137Small intestinal stenosis (HP:0012848)1.75535105
138Clubbing of toes (HP:0100760)1.74607943
139Cystic hygroma (HP:0000476)1.73947392
140Abnormality of DNA repair (HP:0003254)1.73782509
141Embryonal neoplasm (HP:0002898)1.73613351
142Poor coordination (HP:0002370)1.73408793
143Exercise-induced muscle cramps (HP:0003710)1.68671726
144Uterine neoplasm (HP:0010784)1.68466295
145Abnormality of the pancreatic islet cells (HP:0006476)1.68259722
146Abnormality of endocrine pancreas physiology (HP:0012093)1.68259722
147Freckling (HP:0001480)1.68025953
148Abnormality of the anterior horn cell (HP:0006802)1.66991380
149Degeneration of anterior horn cells (HP:0002398)1.66991380
150Pancreatic islet-cell hyperplasia (HP:0004510)1.65749680
151Bifid tongue (HP:0010297)1.65681060
152Postnatal microcephaly (HP:0005484)1.65226991
153Neuroblastoma (HP:0003006)1.64002034
154Primitive neuroectodermal tumor (HP:0030065)1.64002034
155Neuroblastic tumors (HP:0004376)1.64002034
156Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.64002034
157Abnormality of methionine metabolism (HP:0010901)1.63537924
158Abnormality of the duodenum (HP:0002246)1.62627942
159Spastic diplegia (HP:0001264)1.62162262
160Deep philtrum (HP:0002002)1.61839862
161Proximal tubulopathy (HP:0000114)1.61250981
162Breast carcinoma (HP:0003002)1.60891788
163Sloping forehead (HP:0000340)1.60779680
164Abnormal biliary tract morphology (HP:0012440)1.59973025
165Selective tooth agenesis (HP:0001592)1.58364390
166Curly hair (HP:0002212)1.57724560
167Cutaneous melanoma (HP:0012056)1.57292648
168Asymmetry of the thorax (HP:0001555)1.56756746
169Scrotal hypoplasia (HP:0000046)1.55706402
170Abnormality of the lower motor neuron (HP:0002366)1.55484476
171Septate vagina (HP:0001153)1.53226069
172Abnormality of the metopic suture (HP:0005556)1.52652684
173Absent eyelashes (HP:0000561)1.52466383
174Cafe-au-lait spot (HP:0000957)1.51473043
175Symptomatic seizures (HP:0011145)1.50766204
176Secondary amenorrhea (HP:0000869)1.50224745
177Megaloblastic anemia (HP:0001889)1.49247673
178Gastrointestinal carcinoma (HP:0002672)1.48626379
179Malignant gastrointestinal tract tumors (HP:0006749)1.48626379
180Myelomeningocele (HP:0002475)1.48105730
181Abnormality of the carotid arteries (HP:0005344)1.47692818
182Subaortic stenosis (HP:0001682)1.46847664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.04554551
2CASK3.52032561
3TNIK3.03714262
4TSSK62.86496611
5NTRK32.79744827
6SRPK12.61828470
7PBK2.41203756
8MAP2K72.40825222
9MKNK22.38283511
10TRIM282.36862162
11NTRK22.34172501
12WEE12.33739914
13PASK2.26605302
14VRK12.24114117
15MAP3K122.15217758
16MST42.11494112
17BUB12.08553275
18BCR2.08110768
19PNCK2.07083986
20LATS11.98704738
21SCYL21.96024381
22MKNK11.92035563
23ERBB31.89331195
24TAF11.79188659
25NEK11.79151508
26CSNK1G31.64271985
27EIF2AK31.48588404
28EPHA41.47160140
29MUSK1.46703803
30BRD41.35072627
31LATS21.34830693
32MST1R1.34572351
33CDK191.33454582
34NME11.32273531
35CSNK1G21.32253100
36CSNK1A1L1.29179748
37STK391.28383730
38AKT31.28028257
39EIF2AK21.25972370
40TTK1.25333621
41CSNK1G11.24391569
42EIF2AK11.23350665
43STK31.22399387
44MAP3K41.21242105
45IRAK41.19047162
46CDK81.14257508
47YES11.12188694
48CCNB11.11483757
49PLK41.08652299
50MAPK131.07135634
51INSRR1.06851513
52TLK11.05149045
53BMPR1B1.05141157
54PLK31.04465776
55TXK1.01173532
56NEK21.00204749
57MAP4K21.00022079
58ZAK0.96750157
59CDC70.96466725
60MET0.96354154
61DAPK10.95987565
62ATR0.95079125
63NUAK10.93798071
64BCKDK0.91479219
65PLK10.89729570
66BRSK20.86978891
67DYRK30.86904039
68STK240.86660805
69FES0.82749578
70WNK30.82289725
71CDK60.80880709
72GRK10.79659052
73CDK30.79385019
74TEC0.76119648
75CDK70.73257107
76RPS6KA40.66593863
77CSNK2A20.66279647
78WNK40.65491604
79NEK60.65192722
80LIMK10.64876704
81PRKCG0.64147264
82MAP3K100.63620370
83SIK30.63064708
84CHEK20.62876200
85MINK10.60796773
86BRAF0.60504548
87MAP2K40.60098990
88KSR10.59785313
89EEF2K0.59082866
90AURKA0.58936834
91CSNK2A10.58476330
92AURKB0.57413401
93PLK20.57206848
94ATM0.56864146
95FER0.55741955
96RPS6KB10.53383929
97MAP3K50.53147440
98CSNK1E0.52305798
99PIK3CG0.51896254
100CAMK2B0.51721087
101AKT20.51649435
102ERBB40.51485776
103EPHA20.51256797
104CAMK2A0.50165096
105MARK10.49606500
106STK38L0.49439461
107CAMK10.48200600
108ACVR1B0.48150487
109UHMK10.47869280
110NEK90.45686494
111PRKCE0.44566920
112MAP3K20.43404385
113PAK40.42691066
114FRK0.40324315
115ALK0.39946216
116MAP3K90.39901969
117CHEK10.39165309
118PRKD30.38357867
119STK110.37682335
120CDK20.36672781
121CDK10.36620229
122TGFBR10.36323468
123CAMK2G0.35690997
124MAP2K60.35491848
125BRSK10.35265239
126CDK140.33995682
127ICK0.33985963
128ADRBK20.33905209
129IRAK30.33823260
130PRKACA0.33765222
131MAP3K60.33019835
132TNK20.32436734
133PDGFRA0.32202584
134CDK50.31903053
135RPS6KB20.31558168
136PRKDC0.31232940
137FGFR10.31087996
138NME20.30535820

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.78401932
2DNA replication_Homo sapiens_hsa030303.70326664
3Mismatch repair_Homo sapiens_hsa034303.53205290
4Nicotine addiction_Homo sapiens_hsa050332.91440471
5RNA polymerase_Homo sapiens_hsa030202.81336635
6Vitamin B6 metabolism_Homo sapiens_hsa007502.75999699
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71777328
8Fanconi anemia pathway_Homo sapiens_hsa034602.63149884
9Proteasome_Homo sapiens_hsa030502.46713914
10Homologous recombination_Homo sapiens_hsa034402.42353206
11Spliceosome_Homo sapiens_hsa030402.35153499
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26444687
13Protein export_Homo sapiens_hsa030602.25537696
14Pyrimidine metabolism_Homo sapiens_hsa002402.17698023
15Oxidative phosphorylation_Homo sapiens_hsa001902.16137368
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13400240
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.08010321
18Nucleotide excision repair_Homo sapiens_hsa034202.01630952
19One carbon pool by folate_Homo sapiens_hsa006702.01148818
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92860183
21Steroid biosynthesis_Homo sapiens_hsa001001.86859009
22Base excision repair_Homo sapiens_hsa034101.85170665
23Parkinsons disease_Homo sapiens_hsa050121.71887339
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68064281
25Basal transcription factors_Homo sapiens_hsa030221.68025386
26RNA transport_Homo sapiens_hsa030131.66472264
27Non-homologous end-joining_Homo sapiens_hsa034501.65519339
28Propanoate metabolism_Homo sapiens_hsa006401.64829073
29RNA degradation_Homo sapiens_hsa030181.60881735
30Purine metabolism_Homo sapiens_hsa002301.51468607
31Pyruvate metabolism_Homo sapiens_hsa006201.47887781
32Biosynthesis of amino acids_Homo sapiens_hsa012301.44691796
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44198091
34Amphetamine addiction_Homo sapiens_hsa050311.41892910
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37570836
36Huntingtons disease_Homo sapiens_hsa050161.36115467
37p53 signaling pathway_Homo sapiens_hsa041151.29630976
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29494425
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28839147
40Alzheimers disease_Homo sapiens_hsa050101.24190263
41Phototransduction_Homo sapiens_hsa047441.23800354
42Insulin secretion_Homo sapiens_hsa049111.22551606
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20762490
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16944032
45Carbon metabolism_Homo sapiens_hsa012001.16768060
46Taste transduction_Homo sapiens_hsa047421.16705309
47Serotonergic synapse_Homo sapiens_hsa047261.13781094
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10470913
49Circadian entrainment_Homo sapiens_hsa047131.08300468
50GABAergic synapse_Homo sapiens_hsa047271.07898526
51Hippo signaling pathway_Homo sapiens_hsa043901.06202651
52Cell cycle_Homo sapiens_hsa041101.05580818
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.05018988
54Fatty acid metabolism_Homo sapiens_hsa012121.04359357
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01437887
56TGF-beta signaling pathway_Homo sapiens_hsa043500.97267270
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97126981
58Glutamatergic synapse_Homo sapiens_hsa047240.96926420
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95425614
60Morphine addiction_Homo sapiens_hsa050320.95146162
61Thyroid cancer_Homo sapiens_hsa052160.93701126
62Folate biosynthesis_Homo sapiens_hsa007900.90406457
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88212740
64Cocaine addiction_Homo sapiens_hsa050300.88212468
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86029459
66mRNA surveillance pathway_Homo sapiens_hsa030150.84101344
67Synaptic vesicle cycle_Homo sapiens_hsa047210.80531392
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.80243317
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.78683481
70Regulation of autophagy_Homo sapiens_hsa041400.75152228
71Adherens junction_Homo sapiens_hsa045200.74107583
72Long-term potentiation_Homo sapiens_hsa047200.72666825
73Sulfur relay system_Homo sapiens_hsa041220.71042721
74Fatty acid elongation_Homo sapiens_hsa000620.68148720
75beta-Alanine metabolism_Homo sapiens_hsa004100.67817883
76Fatty acid biosynthesis_Homo sapiens_hsa000610.65498438
77Metabolic pathways_Homo sapiens_hsa011000.63254891
78Selenocompound metabolism_Homo sapiens_hsa004500.62859438
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61995929
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61856760
81Oocyte meiosis_Homo sapiens_hsa041140.61700037
82Calcium signaling pathway_Homo sapiens_hsa040200.59765151
83Phenylalanine metabolism_Homo sapiens_hsa003600.59404707
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58795889
85Tight junction_Homo sapiens_hsa045300.57370115
86Cardiac muscle contraction_Homo sapiens_hsa042600.56253499
87Lysine degradation_Homo sapiens_hsa003100.55864838
88Sulfur metabolism_Homo sapiens_hsa009200.55736057
89Dopaminergic synapse_Homo sapiens_hsa047280.55543515
90Fatty acid degradation_Homo sapiens_hsa000710.54530704
91Collecting duct acid secretion_Homo sapiens_hsa049660.53876192
92Hedgehog signaling pathway_Homo sapiens_hsa043400.52805256
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51427224
94MicroRNAs in cancer_Homo sapiens_hsa052060.51100289
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50180770
96Histidine metabolism_Homo sapiens_hsa003400.49611926
97Pentose phosphate pathway_Homo sapiens_hsa000300.48624910
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48050622
99Alcoholism_Homo sapiens_hsa050340.48044225
100Colorectal cancer_Homo sapiens_hsa052100.47791769
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45868152
102Vibrio cholerae infection_Homo sapiens_hsa051100.43391871
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43389408
104Long-term depression_Homo sapiens_hsa047300.42583658
105Arginine biosynthesis_Homo sapiens_hsa002200.42469302
106Wnt signaling pathway_Homo sapiens_hsa043100.41758391
107Melanoma_Homo sapiens_hsa052180.41750570
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41598269
109Linoleic acid metabolism_Homo sapiens_hsa005910.41024316
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.39960337
111Peroxisome_Homo sapiens_hsa041460.39697507
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39297929
113Renin secretion_Homo sapiens_hsa049240.38074197
114Arachidonic acid metabolism_Homo sapiens_hsa005900.36596051
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36077121
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34779859
117Prostate cancer_Homo sapiens_hsa052150.34035161
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33946090
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33625142
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32860955
121N-Glycan biosynthesis_Homo sapiens_hsa005100.32440385
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32153673
123Butanoate metabolism_Homo sapiens_hsa006500.31923067
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31326290
125Salivary secretion_Homo sapiens_hsa049700.31212611
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30697282
127Glutathione metabolism_Homo sapiens_hsa004800.29889088
128Circadian rhythm_Homo sapiens_hsa047100.28360389
129Basal cell carcinoma_Homo sapiens_hsa052170.28048310
130Arginine and proline metabolism_Homo sapiens_hsa003300.27973688
131Endometrial cancer_Homo sapiens_hsa052130.27773942
132Small cell lung cancer_Homo sapiens_hsa052220.26402663
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26143700
134Olfactory transduction_Homo sapiens_hsa047400.25415368
135Proteoglycans in cancer_Homo sapiens_hsa052050.24742873
136Inositol phosphate metabolism_Homo sapiens_hsa005620.24422476
137Tyrosine metabolism_Homo sapiens_hsa003500.24104745
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22722622
139Glucagon signaling pathway_Homo sapiens_hsa049220.22720217
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22267482
141AMPK signaling pathway_Homo sapiens_hsa041520.21591961
142Cholinergic synapse_Homo sapiens_hsa047250.20743047
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.19093048

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »