TRUB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.23695699
2nucleobase biosynthetic process (GO:0046112)4.90303468
3DNA strand elongation involved in DNA replication (GO:0006271)4.80886890
4DNA replication initiation (GO:0006270)4.67612345
5behavioral response to nicotine (GO:0035095)4.65280151
6IMP biosynthetic process (GO:0006188)4.64575155
7mitotic metaphase plate congression (GO:0007080)4.61351014
8DNA strand elongation (GO:0022616)4.57207470
9ribosome biogenesis (GO:0042254)4.49964769
10maturation of SSU-rRNA (GO:0030490)4.47129968
11purine nucleobase biosynthetic process (GO:0009113)4.43716198
12ribosomal large subunit biogenesis (GO:0042273)4.39100288
13ribonucleoprotein complex biogenesis (GO:0022613)4.29236552
14tRNA methylation (GO:0030488)4.16637874
15negative regulation of telomere maintenance (GO:0032205)4.13199536
16negative regulation of organelle assembly (GO:1902116)4.12028819
17IMP metabolic process (GO:0046040)4.10127573
18viral transcription (GO:0019083)4.09060466
19telomere maintenance via semi-conservative replication (GO:0032201)4.09029300
20protein localization to kinetochore (GO:0034501)4.06496478
21translational termination (GO:0006415)4.04529781
22spliceosomal snRNP assembly (GO:0000387)4.02836381
23formation of translation preinitiation complex (GO:0001731)4.02689206
24DNA replication checkpoint (GO:0000076)4.00162672
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.98034988
26ribosome assembly (GO:0042255)3.97224251
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.96224856
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.96224856
29NADH dehydrogenase complex assembly (GO:0010257)3.96224856
30folic acid-containing compound biosynthetic process (GO:0009396)3.95848784
31regulation of gene silencing by RNA (GO:0060966)3.91763818
32regulation of posttranscriptional gene silencing (GO:0060147)3.91763818
33regulation of gene silencing by miRNA (GO:0060964)3.91763818
34metaphase plate congression (GO:0051310)3.82130404
35tRNA modification (GO:0006400)3.77078896
36atrial cardiac muscle cell action potential (GO:0086014)3.75974366
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.72544999
38protein complex biogenesis (GO:0070271)3.72377114
39DNA replication-dependent nucleosome assembly (GO:0006335)3.70748156
40DNA replication-dependent nucleosome organization (GO:0034723)3.70748156
41translational elongation (GO:0006414)3.70086172
42translational initiation (GO:0006413)3.69473609
43mitotic nuclear envelope disassembly (GO:0007077)3.67931620
44mitochondrial respiratory chain complex assembly (GO:0033108)3.64009645
45DNA deamination (GO:0045006)3.61097741
46cellular ketone body metabolic process (GO:0046950)3.60845932
47rRNA processing (GO:0006364)3.59382368
48ribosomal small subunit biogenesis (GO:0042274)3.57839247
49amino acid salvage (GO:0043102)3.56054213
50L-methionine salvage (GO:0071267)3.56054213
51L-methionine biosynthetic process (GO:0071265)3.56054213
52protein localization to chromosome, centromeric region (GO:0071459)3.55666675
53mannosylation (GO:0097502)3.55102945
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.52326540
55telomere maintenance via recombination (GO:0000722)3.52209974
56peptidyl-arginine omega-N-methylation (GO:0035247)3.51590027
57kidney morphogenesis (GO:0060993)3.49522167
58ubiquinone biosynthetic process (GO:0006744)3.48962295
59rRNA metabolic process (GO:0016072)3.47742864
60respiratory chain complex IV assembly (GO:0008535)3.47723027
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47302642
62arginine catabolic process (GO:0006527)3.43767451
63ribosomal small subunit assembly (GO:0000028)3.41933343
64peristalsis (GO:0030432)3.41348212
65mitotic recombination (GO:0006312)3.38358857
66telomere maintenance via telomere lengthening (GO:0010833)3.38312619
67water-soluble vitamin biosynthetic process (GO:0042364)3.37915154
68nuclear envelope disassembly (GO:0051081)3.36875668
69membrane disassembly (GO:0030397)3.36875668
70preassembly of GPI anchor in ER membrane (GO:0016254)3.33598329
71SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.29870711
72DNA-dependent DNA replication (GO:0006261)3.29696875
73regulation of spindle organization (GO:0090224)3.28946879
74mitochondrial RNA metabolic process (GO:0000959)3.27637039
75rRNA modification (GO:0000154)3.27135990
76cellular protein complex disassembly (GO:0043624)3.26071939
77somatic hypermutation of immunoglobulin genes (GO:0016446)3.24992706
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24992706
79ubiquinone metabolic process (GO:0006743)3.24005083
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23701173
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23701173
82cotranslational protein targeting to membrane (GO:0006613)3.23693850
83cellular component biogenesis (GO:0044085)3.23049357
84ketone body metabolic process (GO:1902224)3.23010626
85histone arginine methylation (GO:0034969)3.21513497
86transcription elongation from RNA polymerase III promoter (GO:0006385)3.21125167
87termination of RNA polymerase III transcription (GO:0006386)3.21125167
88protein targeting to ER (GO:0045047)3.21060947
89maturation of 5.8S rRNA (GO:0000460)3.20933145
90establishment of chromosome localization (GO:0051303)3.20258453
91histone H2A acetylation (GO:0043968)3.19988182
92nuclear pore organization (GO:0006999)3.19276766
93mitotic sister chromatid segregation (GO:0000070)3.17482085
94DNA duplex unwinding (GO:0032508)3.15153442
95DNA geometric change (GO:0032392)3.12577222
96viral life cycle (GO:0019058)3.12085261
97* pseudouridine synthesis (GO:0001522)3.11754871
98regulation of hippo signaling (GO:0035330)3.11512978
99L-fucose metabolic process (GO:0042354)3.10274032
100L-fucose catabolic process (GO:0042355)3.10274032
101fucose catabolic process (GO:0019317)3.10274032
102urinary tract smooth muscle contraction (GO:0014848)3.09764014
103transcription elongation from RNA polymerase I promoter (GO:0006362)3.07949135
104positive regulation of respiratory burst (GO:0060267)3.07298024
105transcription-coupled nucleotide-excision repair (GO:0006283)3.07019653
106spliceosomal tri-snRNP complex assembly (GO:0000244)3.06041621
107* tRNA processing (GO:0008033)3.06021988
108establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05518102
109termination of RNA polymerase I transcription (GO:0006363)3.05517159
110regulation of nuclear cell cycle DNA replication (GO:0033262)3.05516578
111CENP-A containing nucleosome assembly (GO:0034080)3.04853144
112energy coupled proton transport, down electrochemical gradient (GO:0015985)3.04286235
113ATP synthesis coupled proton transport (GO:0015986)3.04286235
114attachment of spindle microtubules to kinetochore (GO:0008608)3.03033121
115negative regulation of chromosome segregation (GO:0051985)3.02407036
116transcription from RNA polymerase I promoter (GO:0006360)3.02038673
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01736084
118cornea development in camera-type eye (GO:0061303)3.01287011
119cytochrome complex assembly (GO:0017004)3.00549544
120chromatin remodeling at centromere (GO:0031055)2.99136365
121methionine biosynthetic process (GO:0009086)2.98261949
122peptidyl-histidine modification (GO:0018202)2.98119937
123protein complex disassembly (GO:0043241)2.98043457
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97966545
125negative regulation of sister chromatid segregation (GO:0033046)2.97297176
126negative regulation of mitotic sister chromatid separation (GO:2000816)2.97297176
127negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97297176
128negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97297176
129positive regulation of guanylate cyclase activity (GO:0031284)2.97030239
130spindle checkpoint (GO:0031577)2.96613746
131nucleotide-excision repair, DNA gap filling (GO:0006297)2.96435190
132protein localization to endoplasmic reticulum (GO:0070972)2.96382811
133DNA replication-independent nucleosome assembly (GO:0006336)2.95334962
134DNA replication-independent nucleosome organization (GO:0034724)2.95334962
135regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94296078
136mitotic spindle checkpoint (GO:0071174)2.93675222
137base-excision repair (GO:0006284)2.93538950
138peptidyl-arginine methylation (GO:0018216)2.93245425
139peptidyl-arginine N-methylation (GO:0035246)2.93245425
140negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92692042
141kinetochore organization (GO:0051383)2.91996082
142mitotic chromosome condensation (GO:0007076)2.91549614
143protein complex localization (GO:0031503)2.91056172
144translation (GO:0006412)2.90840442
145arginine metabolic process (GO:0006525)2.90237512
146regulation of mitochondrial translation (GO:0070129)2.88854404
147kynurenine metabolic process (GO:0070189)2.88647892
148aspartate family amino acid catabolic process (GO:0009068)2.87880991
149meiotic chromosome segregation (GO:0045132)2.85472138
150mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83654512
151gap junction assembly (GO:0016264)2.83366491
152piRNA metabolic process (GO:0034587)2.82690066
153reciprocal meiotic recombination (GO:0007131)2.81810258
154reciprocal DNA recombination (GO:0035825)2.81810258
155proteasome assembly (GO:0043248)2.78606196
156aldehyde catabolic process (GO:0046185)2.77529610
157endosome to pigment granule transport (GO:0043485)2.77302825
158endosome to melanosome transport (GO:0035646)2.77302825
159mitochondrion morphogenesis (GO:0070584)2.76154440
160quinone biosynthetic process (GO:1901663)2.73144837
161antigen processing and presentation via MHC class Ib (GO:0002475)2.70490391
162regulation of microtubule-based movement (GO:0060632)2.68812656
163DNA methylation involved in gamete generation (GO:0043046)2.67765282
164response to misfolded protein (GO:0051788)2.64942950
165mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.63800458
166sulfate transport (GO:0008272)2.63323177
167* tRNA metabolic process (GO:0006399)2.62588713
168regulation of guanylate cyclase activity (GO:0031282)2.61801639
169detection of light stimulus involved in sensory perception (GO:0050962)2.61717557
170detection of light stimulus involved in visual perception (GO:0050908)2.61717557
171lysine metabolic process (GO:0006553)2.60861390
172lysine catabolic process (GO:0006554)2.60861390
173protein-cofactor linkage (GO:0018065)2.59795584
174rRNA catabolic process (GO:0016075)2.59387730
175replication fork processing (GO:0031297)2.59380705
176protein polyglutamylation (GO:0018095)2.58522625
177drug catabolic process (GO:0042737)2.56989816
178intracellular protein transmembrane import (GO:0044743)2.56836444
179positive regulation of CREB transcription factor activity (GO:0032793)2.55952834
180protein import into peroxisome matrix (GO:0016558)2.55829723
181detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.53139265
182exogenous drug catabolic process (GO:0042738)2.52833712
183* RNA modification (GO:0009451)2.51371815
184metallo-sulfur cluster assembly (GO:0031163)2.51339936
185iron-sulfur cluster assembly (GO:0016226)2.51339936
186biotin metabolic process (GO:0006768)2.50865946
187regulation of respiratory system process (GO:0044065)2.50580298
188indolalkylamine catabolic process (GO:0046218)2.49213831

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.18032250
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.56728297
3ZNF274_21170338_ChIP-Seq_K562_Hela3.95155431
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.55698491
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41868192
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.39707912
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35248744
8* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20731731
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.09329173
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03659450
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00930831
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.94498674
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94457645
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91551315
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84430411
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79473143
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.77528924
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76096307
19* GABP_17652178_ChIP-ChIP_JURKAT_Human2.73262860
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.63232509
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54775269
22VDR_22108803_ChIP-Seq_LS180_Human2.51461920
23* XRN2_22483619_ChIP-Seq_HELA_Human2.37221445
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29070292
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25931764
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17712443
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15581360
28NANOG_18555785_ChIP-Seq_MESCs_Mouse2.14694520
29AR_21909140_ChIP-Seq_LNCAP_Human2.10191262
30* VDR_23849224_ChIP-Seq_CD4+_Human2.09957464
31MYCN_18555785_ChIP-Seq_MESCs_Mouse2.06327659
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.04644416
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03805751
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.98567196
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95528069
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.93131435
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.91882567
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90044974
39* GABP_19822575_ChIP-Seq_HepG2_Human1.88963882
40CIITA_25753668_ChIP-Seq_RAJI_Human1.87959494
41GATA1_22025678_ChIP-Seq_K562_Human1.87701184
42* DCP1A_22483619_ChIP-Seq_HELA_Human1.85358826
43TTF2_22483619_ChIP-Seq_HELA_Human1.83524472
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.81951720
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80497478
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80029000
47ERA_21632823_ChIP-Seq_H3396_Human1.77401804
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76069982
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74560519
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73214290
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.72244653
52KDM5A_27292631_Chip-Seq_BREAST_Human1.72211651
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71701261
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70082910
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.69991396
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67574071
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67128004
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66014478
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66014478
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66014478
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59045729
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56871392
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56809141
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56492898
65TP53_22573176_ChIP-Seq_HFKS_Human1.56041679
66IRF1_19129219_ChIP-ChIP_H3396_Human1.54017018
67MYC_22102868_ChIP-Seq_BL_Human1.50763758
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48914976
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48072624
70* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44860010
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44728544
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.39396599
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38955967
74* FOXP1_21924763_ChIP-Seq_HESCs_Human1.37331526
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36449084
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35795452
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35636428
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35018406
79ELK1_19687146_ChIP-ChIP_HELA_Human1.34587816
80* GATA3_21878914_ChIP-Seq_MCF-7_Human1.34367736
81* HOXB7_26014856_ChIP-Seq_BT474_Human1.33679470
82YY1_22570637_ChIP-Seq_MALME-3M_Human1.31651438
83P53_21459846_ChIP-Seq_SAOS-2_Human1.31463850
84EWS_26573619_Chip-Seq_HEK293_Human1.28944259
85PHF8_20622854_ChIP-Seq_HELA_Human1.28365461
86TFEB_21752829_ChIP-Seq_HELA_Human1.28075199
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27247745
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.25152017
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23525093
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22626397
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21853887
92E2F1_20622854_ChIP-Seq_HELA_Human1.21214797
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20609083
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20275413
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20098080
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.19250755
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19250755
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18900069
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18594143
100* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16665263
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15392322
102ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15088561
103NANOG_20526341_ChIP-Seq_ESCs_Human1.13578406
104ER_23166858_ChIP-Seq_MCF-7_Human1.13389199
105RAC3_21632823_ChIP-Seq_H3396_Human1.13234477
106TAF2_19829295_ChIP-Seq_ESCs_Human1.13008752
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12491021
108EZH2_22144423_ChIP-Seq_EOC_Human1.10747586
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10516817
110NOTCH1_21737748_ChIP-Seq_TLL_Human1.09957633
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09528893
112* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08980548
113NANOG_21062744_ChIP-ChIP_HESCs_Human1.08659787
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08621265
115* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08198148
116CTCF_20526341_ChIP-Seq_ESCs_Human1.07902532
117P68_20966046_ChIP-Seq_HELA_Human1.07607276
118SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07329078
119REST_21632747_ChIP-Seq_MESCs_Mouse1.06983553
120TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06562480
121* MYC_19829295_ChIP-Seq_ESCs_Human1.06051624
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04626259
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04040526
124RARB_24833708_ChIP-Seq_LIVER_Mouse1.03403027
125SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02197790
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01710649
127NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01129016
128NCOR_22424771_ChIP-Seq_293T_Human1.01122692
129OCT4_20526341_ChIP-Seq_ESCs_Human1.00624269
130AR_20517297_ChIP-Seq_VCAP_Human1.00304591
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00251636
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99094096
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98980898
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98731830
135PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97556137
136* BCL6_27268052_Chip-Seq_Bcells_Human0.96330839
137SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95587712
138SALL1_21062744_ChIP-ChIP_HESCs_Human0.95098387
139TET1_21451524_ChIP-Seq_MESCs_Mouse0.95029052
140GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94566971
141VDR_21846776_ChIP-Seq_THP-1_Human0.94251929
142CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93903177
143CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93470396
144MYC_18940864_ChIP-ChIP_HL60_Human0.92118563
145TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91359008
146CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90852818
147CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90756593
148TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89974735
149REST_18959480_ChIP-ChIP_MESCs_Mouse0.89962938
150POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.89374949
151OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88256763
152ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87882281
153SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87737834
154BCOR_27268052_Chip-Seq_Bcells_Human0.85837136
155PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85185465
156E2F1_17053090_ChIP-ChIP_MCF-7_Human0.85157147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.17612755
2MP0003111_abnormal_nucleus_morphology4.63454288
3MP0003693_abnormal_embryo_hatching4.62099919
4MP0008057_abnormal_DNA_replication4.38436860
5MP0004957_abnormal_blastocyst_morpholog4.11676818
6MP0003077_abnormal_cell_cycle4.01977350
7MP0010094_abnormal_chromosome_stability3.89552766
8MP0003646_muscle_fatigue3.58524264
9MP0008058_abnormal_DNA_repair3.44460217
10MP0006292_abnormal_olfactory_placode3.03269409
11MP0008932_abnormal_embryonic_tissue2.74579045
12MP0001730_embryonic_growth_arrest2.64346570
13MP0004043_abnormal_pH_regulation2.60685885
14MP0008875_abnormal_xenobiotic_pharmacok2.58863621
15MP0008007_abnormal_cellular_replicative2.56331236
16MP0008872_abnormal_physiological_respon2.47555788
17MP0002735_abnormal_chemical_nociception2.41836794
18MP0000350_abnormal_cell_proliferation2.33791648
19MP0001348_abnormal_lacrimal_gland2.33468533
20MP0004133_heterotaxia2.16395515
21MP0005167_abnormal_blood-brain_barrier2.15990925
22MP0001293_anophthalmia2.14046275
23MP0005645_abnormal_hypothalamus_physiol2.09748017
24MP0009046_muscle_twitch2.08076318
25MP0005551_abnormal_eye_electrophysiolog2.00463354
26MP0009697_abnormal_copulation1.95556068
27MP0001672_abnormal_embryogenesis/_devel1.89614692
28MP0005380_embryogenesis_phenotype1.89614692
29MP0001697_abnormal_embryo_size1.85954249
30MP0003123_paternal_imprinting1.83654927
31MP0003195_calcinosis1.83142813
32MP0003890_abnormal_embryonic-extraembry1.82235381
33MP0002085_abnormal_embryonic_tissue1.81493847
34MP0010030_abnormal_orbit_morphology1.81172979
35MP0002837_dystrophic_cardiac_calcinosis1.76971515
36MP0003984_embryonic_growth_retardation1.71674842
37MP0001968_abnormal_touch/_nociception1.69253826
38MP0002088_abnormal_embryonic_growth/wei1.68420876
39MP0002080_prenatal_lethality1.66127952
40MP0004197_abnormal_fetal_growth/weight/1.65571958
41MP0002876_abnormal_thyroid_physiology1.65095558
42MP0003137_abnormal_impulse_conducting1.62122402
43MP0002084_abnormal_developmental_patter1.55229421
44MP0003136_yellow_coat_color1.51165152
45MP0005646_abnormal_pituitary_gland1.50782728
46MP0002396_abnormal_hematopoietic_system1.42837438
47MP0010307_abnormal_tumor_latency1.41969444
48MP0009840_abnormal_foam_cell1.40256088
49MP0009745_abnormal_behavioral_response1.38799440
50MP0002736_abnormal_nociception_after1.37048649
51MP0003806_abnormal_nucleotide_metabolis1.36830360
52MP0000427_abnormal_hair_cycle1.35901603
53MP0010352_gastrointestinal_tract_polyps1.34674096
54MP0003941_abnormal_skin_development1.32990957
55MP0003567_abnormal_fetal_cardiomyocyte1.31010159
56MP0005253_abnormal_eye_physiology1.29131800
57MP0000428_abnormal_craniofacial_morphol1.28794189
58MP0001986_abnormal_taste_sensitivity1.28422782
59MP0000490_abnormal_crypts_of1.27839173
60MP0002938_white_spotting1.26754080
61MP0000372_irregular_coat_pigmentation1.25525490
62MP0008775_abnormal_heart_ventricle1.25251130
63MP0003786_premature_aging1.24391841
64MP0002733_abnormal_thermal_nociception1.23708545
65MP0002086_abnormal_extraembryonic_tissu1.22254648
66MP0009672_abnormal_birth_weight1.22225529
67MP0006276_abnormal_autonomic_nervous1.19539006
68MP0002272_abnormal_nervous_system1.19380279
69MP0005377_hearing/vestibular/ear_phenot1.18047616
70MP0003878_abnormal_ear_physiology1.18047616
71MP0001970_abnormal_pain_threshold1.17890583
72MP0000313_abnormal_cell_death1.17764253
73MP0003119_abnormal_digestive_system1.17741505
74MP0004924_abnormal_behavior1.17188432
75MP0005386_behavior/neurological_phenoty1.17188432
76MP0003937_abnormal_limbs/digits/tail_de1.16106347
77MP0001529_abnormal_vocalization1.15117240
78MP0003950_abnormal_plasma_membrane1.14449068
79MP0001905_abnormal_dopamine_level1.14362851
80MP0004142_abnormal_muscle_tone1.13760767
81MP0002249_abnormal_larynx_morphology1.13741380
82MP0005084_abnormal_gallbladder_morpholo1.12946039
83MP0000049_abnormal_middle_ear1.10411999
84MP0006036_abnormal_mitochondrial_physio1.09369471
85MP0002102_abnormal_ear_morphology1.09245356
86MP0003938_abnormal_ear_development1.08957464
87MP0003186_abnormal_redox_activity1.07701694
88MP0008260_abnormal_autophagy1.07539444
89MP0002653_abnormal_ependyma_morphology1.07035269
90MP0005360_urolithiasis1.06772375
91MP0005389_reproductive_system_phenotype1.04240005
92MP0005332_abnormal_amino_acid1.02924732
93MP0005670_abnormal_white_adipose1.02721054
94MP0003718_maternal_effect1.02143459
95MP0000733_abnormal_muscle_development1.01491023
96MP0000358_abnormal_cell_content/1.01488255
97MP0002092_abnormal_eye_morphology1.01060748
98MP0006072_abnormal_retinal_apoptosis1.00923224
99MP0002019_abnormal_tumor_incidence0.99432062
100MP0002111_abnormal_tail_morphology0.98611554
101MP0001286_abnormal_eye_development0.98282624
102MP0005410_abnormal_fertilization0.98203024
103MP0001485_abnormal_pinna_reflex0.98062073
104MP0004185_abnormal_adipocyte_glucose0.97690634
105MP0004885_abnormal_endolymph0.97245959
106MP0002210_abnormal_sex_determination0.96658242
107MP0002822_catalepsy0.94876692
108MP0008961_abnormal_basal_metabolism0.94529248
109MP0003861_abnormal_nervous_system0.94043744
110MP0000015_abnormal_ear_pigmentation0.93864484
111MP0002734_abnormal_mechanical_nocicepti0.93556090
112MP0002557_abnormal_social/conspecific_i0.93237912
113MP0002064_seizures0.92947755
114MP0008877_abnormal_DNA_methylation0.92602286
115MP0002697_abnormal_eye_size0.92345404
116MP0000631_abnormal_neuroendocrine_gland0.91013727
117MP0005083_abnormal_biliary_tract0.90905919
118MP0002572_abnormal_emotion/affect_behav0.90500408
119MP0001764_abnormal_homeostasis0.90312255
120MP0004145_abnormal_muscle_electrophysio0.87621733
121MP0001145_abnormal_male_reproductive0.87020504
122MP0003935_abnormal_craniofacial_develop0.86415195
123MP0000230_abnormal_systemic_arterial0.86190447
124MP0002234_abnormal_pharynx_morphology0.85337852
125MP0000383_abnormal_hair_follicle0.85279586
126MP0000750_abnormal_muscle_regeneration0.85045830
127MP0001849_ear_inflammation0.84959254
128MP0002075_abnormal_coat/hair_pigmentati0.84295202
129MP0008789_abnormal_olfactory_epithelium0.84062388
130MP0002114_abnormal_axial_skeleton0.83875888
131MP0000432_abnormal_head_morphology0.83628948
132MP0003638_abnormal_response/metabolism_0.83592821
133MP0000538_abnormal_urinary_bladder0.82222022
134MP0002638_abnormal_pupillary_reflex0.81414965
135MP0009703_decreased_birth_body0.81338333
136MP0004130_abnormal_muscle_cell0.80834708
137MP0005171_absent_coat_pigmentation0.80015889
138MP0005448_abnormal_energy_balance0.79791877
139MP0002127_abnormal_cardiovascular_syste0.79704993
140MP0002067_abnormal_sensory_capabilities0.78164794
141MP0005085_abnormal_gallbladder_physiolo0.77658041
142MP0001501_abnormal_sleep_pattern0.77631792
143MP0005636_abnormal_mineral_homeostasis0.77517743
144MP0001486_abnormal_startle_reflex0.76261033
145MP0001984_abnormal_olfaction0.75803834
146MP0005257_abnormal_intraocular_pressure0.75654044
147MP0003755_abnormal_palate_morphology0.74320315
148MP0005195_abnormal_posterior_eye0.74117138
149MP0005384_cellular_phenotype0.73081704
150MP0003121_genomic_imprinting0.72715894
151MP0001919_abnormal_reproductive_system0.72227949
152MP0006035_abnormal_mitochondrial_morpho0.71463776
153MP0002751_abnormal_autonomic_nervous0.70393287
154MP0005266_abnormal_metabolism0.69971027
155MP0004085_abnormal_heartbeat0.69770464
156MP0004233_abnormal_muscle_weight0.69736817
157MP0003942_abnormal_urinary_system0.69376267
158MP0009053_abnormal_anal_canal0.69244020
159MP0002116_abnormal_craniofacial_bone0.68905607
160MP0005391_vision/eye_phenotype0.68479699
161MP0004084_abnormal_cardiac_muscle0.68402142
162MP0004808_abnormal_hematopoietic_stem0.68223507
163MP0009333_abnormal_splenocyte_physiolog0.67162182
164MP0000703_abnormal_thymus_morphology0.65431131
165MP0002160_abnormal_reproductive_system0.64987467
166MP0000566_synostosis0.64872933
167MP0006054_spinal_hemorrhage0.64707335
168MP0005621_abnormal_cell_physiology0.64096563
169MP0000747_muscle_weakness0.63824269
170MP0000858_altered_metastatic_potential0.63800962
171MP0002269_muscular_atrophy0.63000761
172MP0000653_abnormal_sex_gland0.62835964
173MP0005174_abnormal_tail_pigmentation0.62566333
174MP0001186_pigmentation_phenotype0.62536775

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.75076253
2Ependymoma (HP:0002888)4.09533357
3Birth length less than 3rd percentile (HP:0003561)4.08840359
4Reticulocytopenia (HP:0001896)3.99180261
5Type II lissencephaly (HP:0007260)3.96772072
6Pancreatic cysts (HP:0001737)3.82517472
7Abnormality of cells of the erythroid lineage (HP:0012130)3.74195167
8Colon cancer (HP:0003003)3.53797159
9Congenital stationary night blindness (HP:0007642)3.45574577
10Patellar aplasia (HP:0006443)3.37518288
11Breast hypoplasia (HP:0003187)3.32067850
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.31681243
13Abnormality of alanine metabolism (HP:0010916)3.31681243
14Hyperalaninemia (HP:0003348)3.31681243
15Abnormality of midbrain morphology (HP:0002418)3.30780260
16Molar tooth sign on MRI (HP:0002419)3.30780260
17Aplasia/Hypoplasia of the sternum (HP:0006714)3.27137507
18Hyperventilation (HP:0002883)3.24782909
19Agnosia (HP:0010524)3.20589067
20Pancreatic fibrosis (HP:0100732)3.20433560
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19024360
22Aplasia/Hypoplasia of the patella (HP:0006498)3.16483652
23Absent radius (HP:0003974)3.16243223
24Aplasia involving forearm bones (HP:0009822)3.10086823
25Absent forearm bone (HP:0003953)3.10086823
26Oral leukoplakia (HP:0002745)3.05100923
27Inability to walk (HP:0002540)3.04094685
28Nephronophthisis (HP:0000090)3.01057126
29Abnormal number of erythroid precursors (HP:0012131)2.98162117
30Abnormality of the labia minora (HP:0012880)2.88282680
31Lissencephaly (HP:0001339)2.86317182
32Increased serum pyruvate (HP:0003542)2.83253686
33Abnormality of glycolysis (HP:0004366)2.83253686
34True hermaphroditism (HP:0010459)2.82016226
35Neoplasm of the oral cavity (HP:0100649)2.81349787
36Premature graying of hair (HP:0002216)2.79000604
37Mitochondrial inheritance (HP:0001427)2.78711187
38Increased CSF lactate (HP:0002490)2.78661943
39Macrocytic anemia (HP:0001972)2.77504715
40Carpal bone hypoplasia (HP:0001498)2.76410380
41Abnormality of the astrocytes (HP:0100707)2.75023913
42Astrocytoma (HP:0009592)2.75023913
43Supernumerary spleens (HP:0009799)2.74532682
44Pendular nystagmus (HP:0012043)2.73253788
45Selective tooth agenesis (HP:0001592)2.72582566
46Acute necrotizing encephalopathy (HP:0006965)2.70748759
47Absent thumb (HP:0009777)2.70596262
48Chromsome breakage (HP:0040012)2.70476832
49Long foot (HP:0001833)2.69354129
50Abnormality of the pons (HP:0007361)2.68385308
51Acute encephalopathy (HP:0006846)2.68165876
52Abnormal number of incisors (HP:0011064)2.67407837
53Abnormal mitochondria in muscle tissue (HP:0008316)2.63147342
54Retinal dysplasia (HP:0007973)2.62556998
55CNS hypomyelination (HP:0003429)2.61445277
56Medulloblastoma (HP:0002885)2.58566992
57Rough bone trabeculation (HP:0100670)2.56126096
58Aplasia/Hypoplasia involving the musculature (HP:0001460)2.55927451
59Facial cleft (HP:0002006)2.55693852
60Hepatocellular necrosis (HP:0001404)2.55528777
61Hypoplasia of the pons (HP:0012110)2.55041312
62Asplenia (HP:0001746)2.52801635
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.50724994
64Neoplasm of the pancreas (HP:0002894)2.50433076
65Impulsivity (HP:0100710)2.48587378
66Abnormality of the renal medulla (HP:0100957)2.46095154
67Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45563817
68Diastasis recti (HP:0001540)2.44695548
69Abnormality of the renal cortex (HP:0011035)2.41799111
70Duplicated collecting system (HP:0000081)2.41722567
71Rhabdomyosarcoma (HP:0002859)2.40253694
72Protruding tongue (HP:0010808)2.39476241
73Hepatic necrosis (HP:0002605)2.39153051
74Postnatal microcephaly (HP:0005484)2.39055976
75Multiple enchondromatosis (HP:0005701)2.39051062
76Slender long bone (HP:0003100)2.37955012
77Meckel diverticulum (HP:0002245)2.37946502
78Female pseudohermaphroditism (HP:0010458)2.37182384
79Horseshoe kidney (HP:0000085)2.36968052
80Aplasia/Hypoplasia of the spleen (HP:0010451)2.36922012
81Attenuation of retinal blood vessels (HP:0007843)2.36683941
82Progressive microcephaly (HP:0000253)2.35815338
83Progressive external ophthalmoplegia (HP:0000590)2.35631004
84Abnormality of the anterior horn cell (HP:0006802)2.35146697
85Degeneration of anterior horn cells (HP:0002398)2.35146697
86Opisthotonus (HP:0002179)2.35094669
87Poor head control (HP:0002421)2.34919898
88Triphalangeal thumb (HP:0001199)2.33522087
89Increased serum lactate (HP:0002151)2.33006586
90Chorioretinal atrophy (HP:0000533)2.32846488
91Abdominal situs inversus (HP:0003363)2.32462227
92Abnormality of abdominal situs (HP:0011620)2.32462227
93Abnormality of the preputium (HP:0100587)2.32410028
94Septo-optic dysplasia (HP:0100842)2.31294089
95Rectal fistula (HP:0100590)2.28483165
96Rectovaginal fistula (HP:0000143)2.28483165
97Large for gestational age (HP:0001520)2.28283213
98Abnormality of the ileum (HP:0001549)2.27876993
99Aplasia/Hypoplasia of the uvula (HP:0010293)2.27494066
100Tracheoesophageal fistula (HP:0002575)2.26364898
101Myokymia (HP:0002411)2.25011800
102Medial flaring of the eyebrow (HP:0010747)2.23603828
103Esophageal atresia (HP:0002032)2.22853579
104Ectopic kidney (HP:0000086)2.22226318
105Poor speech (HP:0002465)2.22066319
106Bone marrow hypocellularity (HP:0005528)2.19743395
107Abnormal lung lobation (HP:0002101)2.19711867
108Atresia of the external auditory canal (HP:0000413)2.19573147
109Cerebellar dysplasia (HP:0007033)2.18236934
110Pallor (HP:0000980)2.17860060
111Abnormality of the renal collecting system (HP:0004742)2.15855971
112Depressed nasal tip (HP:0000437)2.15382604
113Sclerocornea (HP:0000647)2.14408989
114Supernumerary bones of the axial skeleton (HP:0009144)2.13201647
115Stenosis of the external auditory canal (HP:0000402)2.12088770
116Glioma (HP:0009733)2.11707464
117Trismus (HP:0000211)2.11283285
118Cellular immunodeficiency (HP:0005374)2.10985841
119Neoplasm of striated muscle (HP:0009728)2.10429097
120Clumsiness (HP:0002312)2.08805176
121Progressive inability to walk (HP:0002505)2.08364443
122Hypoplastic pelvis (HP:0008839)2.07319442
123Cystic liver disease (HP:0006706)2.06243357
124Lipid accumulation in hepatocytes (HP:0006561)2.05710250
125Scrotal hypoplasia (HP:0000046)2.05483105
126Concave nail (HP:0001598)2.05256707
127Type I transferrin isoform profile (HP:0003642)2.05204461
128External ophthalmoplegia (HP:0000544)2.04321153
129Progressive macrocephaly (HP:0004481)2.03761454
130Microretrognathia (HP:0000308)2.03470957
131Gait imbalance (HP:0002141)2.03450220
132Severe muscular hypotonia (HP:0006829)2.02815001
133Progressive muscle weakness (HP:0003323)2.02104439
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01696089
135Abnormal protein N-linked glycosylation (HP:0012347)2.01696089
136Abnormal protein glycosylation (HP:0012346)2.01696089
137Abnormal glycosylation (HP:0012345)2.01696089
138Lactic acidosis (HP:0003128)2.01581298
139Sloping forehead (HP:0000340)2.00945816
140Tubular atrophy (HP:0000092)2.00749989
141Congenital primary aphakia (HP:0007707)2.00427888
142Gastrointestinal atresia (HP:0002589)1.99714242
143Broad-based gait (HP:0002136)1.98799149
144Proximal placement of thumb (HP:0009623)1.98133759
145Morphological abnormality of the inner ear (HP:0011390)1.97987792
146Intestinal fistula (HP:0100819)1.97738580
147Partial agenesis of the corpus callosum (HP:0001338)1.97659263
148Abnormality of the clitoris (HP:0000056)1.97003894
149Increased hepatocellular lipid droplets (HP:0006565)1.94805889
150Abnormality of cochlea (HP:0000375)1.94277540
151Duplication of thumb phalanx (HP:0009942)1.93932613
152Rib fusion (HP:0000902)1.92909539
153Abolished electroretinogram (ERG) (HP:0000550)1.91469358
154Small intestinal stenosis (HP:0012848)1.90340428
155Duodenal stenosis (HP:0100867)1.90340428
156Facial hemangioma (HP:0000329)1.89171106
157Breast aplasia (HP:0100783)1.88662782
158Large eyes (HP:0001090)1.88429266
159Overlapping toe (HP:0001845)1.88004625
160Supernumerary ribs (HP:0005815)1.87631597
161Secondary amenorrhea (HP:0000869)1.85256504
162Hyperglycinuria (HP:0003108)1.85147588
163Abnormal trabecular bone morphology (HP:0100671)1.82625228
164Congenital, generalized hypertrichosis (HP:0004540)1.82426118
165Nephrogenic diabetes insipidus (HP:0009806)1.82409783
166Optic disc pallor (HP:0000543)1.82139850
167Abnormality of chromosome stability (HP:0003220)1.82126569
168Cerebral edema (HP:0002181)1.81244926
169Basal cell carcinoma (HP:0002671)1.81012351
170Microvesicular hepatic steatosis (HP:0001414)1.80860732
171Aplastic anemia (HP:0001915)1.80471488
172Abnormality of the duodenum (HP:0002246)1.80236874
173Vaginal fistula (HP:0004320)1.80132813
174Microtia (HP:0008551)1.78174616
175Premature ovarian failure (HP:0008209)1.76772963
176Abnormality of the salivary glands (HP:0010286)1.75785921
177Personality changes (HP:0000751)1.75320746
178Bile duct proliferation (HP:0001408)1.74337234
179Abnormal biliary tract physiology (HP:0012439)1.74337234
180Ketosis (HP:0001946)1.72972593
181Squamous cell carcinoma (HP:0002860)1.68054729
182Aplasia/Hypoplasia of the breasts (HP:0010311)1.67823639
183Furrowed tongue (HP:0000221)1.66930609
184Aplasia/Hypoplasia of the tongue (HP:0010295)1.64978370
185Increased intramyocellular lipid droplets (HP:0012240)1.63341044
186Renal Fanconi syndrome (HP:0001994)1.63228915
187Lethargy (HP:0001254)1.63144083
188Genu varum (HP:0002970)1.62624258
189Abnormality of the vitreous humor (HP:0004327)1.62154530
190Dandy-Walker malformation (HP:0001305)1.61393486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.71645481
2BMPR1B5.11645396
3TLK13.67664267
4CDC73.44990912
5DAPK23.40667791
6WEE13.38739018
7FRK3.08785197
8TESK23.00838809
9EIF2AK12.97196514
10NEK22.92724503
11ADRBK22.59773564
12NME22.48198689
13WNK42.44283119
14VRK12.37787165
15TSSK62.22049577
16TTK2.17534519
17EIF2AK32.05761224
18MKNK12.02306838
19CDK71.97660083
20NEK11.96237944
21SRPK11.89160612
22PLK11.86668806
23VRK21.84036354
24CAMKK11.81201949
25MAP4K21.62384959
26GRK11.62060958
27AURKB1.57955686
28ATR1.53294155
29PLK31.52778831
30CHEK21.51489187
31TAOK31.51443242
32BLK1.51192809
33PASK1.49344795
34DYRK31.44233108
35AURKA1.43886045
36INSRR1.42634358
37MKNK21.34658644
38NUAK11.33921424
39ADRBK11.31641638
40EPHA21.31304960
41BCKDK1.29954094
42ZAK1.28064903
43CDK41.27673741
44BRD41.27101170
45CHEK11.25741541
46EEF2K1.23003756
47MAP3K81.20897713
48MAPK131.17985964
49CAMK1D1.16896712
50RPS6KB21.15036100
51DYRK21.11572303
52STK101.10254638
53MAP2K71.09366462
54CAMKK21.08519713
55PINK11.08311177
56LATS21.05607563
57MAP2K61.02286730
58CDK121.00220303
59MARK30.98478628
60CDK20.96313129
61ALK0.92528322
62PIM20.89969261
63ACVR1B0.88510572
64PAK40.87929284
65MELK0.85764196
66NEK90.85354188
67STK38L0.83553903
68TIE10.82954310
69CAMK10.80958960
70PLK40.80574887
71AKT30.80344893
72WNK30.80016985
73RPS6KA40.77684729
74PDK20.77674694
75PRKCI0.75299795
76CDK10.74514819
77ILK0.74298972
78MAPKAPK50.73149608
79STK160.72708825
80CSNK1G30.72172300
81MET0.71997161
82TGFBR10.71943294
83NTRK20.71766839
84CSNK2A20.71740577
85BRSK20.71672492
86PNCK0.71361098
87OXSR10.70584752
88SIK20.69592528
89PTK2B0.69348882
90PHKG10.68502430
91PHKG20.68502430
92YES10.67753056
93PAK10.67719408
94STK40.66663222
95PIM10.66129294
96MAP2K10.64750311
97MAP2K30.64156775
98CSNK1G10.63571045
99ABL20.63016056
100ATM0.61045749
101CSNK1G20.57546313
102AKT20.57414745
103MAP4K10.57334189
104BRSK10.57071414
105CAMK2A0.56166190
106TTN0.55599712
107CSNK1E0.55127559
108CSNK2A10.54731375
109STK390.54700470
110CAMK1G0.54418361
111MAPKAPK30.53907669
112CCNB10.53561074
113CAMK40.52080564
114MAP3K40.51963934
115LIMK10.51813601
116PAK30.51135191
117CSNK1A10.50513446
118TRIB30.49170725
119PRKCG0.48786733
120MAPK150.48688783
121CDK60.47553918
122OBSCN0.45796210
123RPS6KA60.45615299
124RPS6KA50.45175401
125CDK80.44324902
126CSNK1D0.43317431
127LRRK20.41516071
128EIF2AK20.41200823
129PAK60.39920199
130MUSK0.38797066
131GRK60.38686096
132MTOR0.38333732
133MAP2K20.37898373
134CLK10.37276186
135CSNK1A1L0.36959022
136PKN10.36951992
137MAP3K110.36582655
138PRKAA10.34991914
139MAP3K70.33230696
140MAPK90.32306920
141PBK0.32291988
142PAK20.32026952
143MAPK110.31967178
144BRAF0.31911988
145KDR0.31385480
146DAPK30.30282432
147PRKDC0.29265860
148IKBKB0.29232160
149FLT30.28354358
150GSK3B0.26676799
151NME10.24847505
152NLK0.24394692
153CASK0.23869284

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.80182551
2Mismatch repair_Homo sapiens_hsa034304.14728899
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.90050620
4Ribosome_Homo sapiens_hsa030103.76371878
5RNA polymerase_Homo sapiens_hsa030203.75869735
6Spliceosome_Homo sapiens_hsa030403.36730867
7RNA transport_Homo sapiens_hsa030133.17210557
8Base excision repair_Homo sapiens_hsa034103.14806815
9Proteasome_Homo sapiens_hsa030502.89928094
10One carbon pool by folate_Homo sapiens_hsa006702.82999837
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.73548575
12Nucleotide excision repair_Homo sapiens_hsa034202.70673596
13Cell cycle_Homo sapiens_hsa041102.60252616
14Homologous recombination_Homo sapiens_hsa034402.55236593
15Pyrimidine metabolism_Homo sapiens_hsa002402.26247727
16Fanconi anemia pathway_Homo sapiens_hsa034602.11738959
17Basal transcription factors_Homo sapiens_hsa030222.03895449
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02547897
19Nitrogen metabolism_Homo sapiens_hsa009101.95228767
20mRNA surveillance pathway_Homo sapiens_hsa030151.83938375
21Butanoate metabolism_Homo sapiens_hsa006501.80946396
22RNA degradation_Homo sapiens_hsa030181.79216942
23Non-homologous end-joining_Homo sapiens_hsa034501.68867539
24Phototransduction_Homo sapiens_hsa047441.53700341
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52613248
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50904550
27Tryptophan metabolism_Homo sapiens_hsa003801.44925048
28Vitamin B6 metabolism_Homo sapiens_hsa007501.44409659
29p53 signaling pathway_Homo sapiens_hsa041151.39766288
30Sulfur metabolism_Homo sapiens_hsa009201.38927491
31ABC transporters_Homo sapiens_hsa020101.33992945
32Purine metabolism_Homo sapiens_hsa002301.31553273
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26215007
34Sulfur relay system_Homo sapiens_hsa041221.25510934
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23834523
36Alzheimers disease_Homo sapiens_hsa050101.23477433
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17919706
38Peroxisome_Homo sapiens_hsa041461.16031621
39Propanoate metabolism_Homo sapiens_hsa006401.13615047
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11225430
41Biosynthesis of amino acids_Homo sapiens_hsa012301.11047625
42Systemic lupus erythematosus_Homo sapiens_hsa053221.09007193
43Epstein-Barr virus infection_Homo sapiens_hsa051691.07335434
44Chemical carcinogenesis_Homo sapiens_hsa052041.06707497
45Pyruvate metabolism_Homo sapiens_hsa006201.05605297
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03899799
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.03126368
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.02516748
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02464021
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02315526
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.01597859
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01329566
53beta-Alanine metabolism_Homo sapiens_hsa004100.99884579
54Arginine biosynthesis_Homo sapiens_hsa002200.97907864
55Tyrosine metabolism_Homo sapiens_hsa003500.96953650
56Oocyte meiosis_Homo sapiens_hsa041140.96881877
57Fatty acid biosynthesis_Homo sapiens_hsa000610.93420413
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93382332
59Nicotine addiction_Homo sapiens_hsa050330.92126106
60Folate biosynthesis_Homo sapiens_hsa007900.91020984
61Cardiac muscle contraction_Homo sapiens_hsa042600.90888480
62Caffeine metabolism_Homo sapiens_hsa002320.90637474
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90191089
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.86212771
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83675044
66Basal cell carcinoma_Homo sapiens_hsa052170.82222968
67Viral carcinogenesis_Homo sapiens_hsa052030.80645899
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79518080
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77805030
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.77500446
71Retinol metabolism_Homo sapiens_hsa008300.76658864
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75909890
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74261919
74Hedgehog signaling pathway_Homo sapiens_hsa043400.72942718
75Olfactory transduction_Homo sapiens_hsa047400.72555217
76Fatty acid degradation_Homo sapiens_hsa000710.69904189
77HTLV-I infection_Homo sapiens_hsa051660.68372592
78Protein export_Homo sapiens_hsa030600.67016314
79Hippo signaling pathway_Homo sapiens_hsa043900.66594965
80Histidine metabolism_Homo sapiens_hsa003400.66495980
81Glycerolipid metabolism_Homo sapiens_hsa005610.64742746
82MicroRNAs in cancer_Homo sapiens_hsa052060.63112310
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62920485
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62421313
85Selenocompound metabolism_Homo sapiens_hsa004500.62381654
86Fat digestion and absorption_Homo sapiens_hsa049750.62191975
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60889031
88Ovarian steroidogenesis_Homo sapiens_hsa049130.60857157
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60723708
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59973612
91Herpes simplex infection_Homo sapiens_hsa051680.58528095
92Pentose phosphate pathway_Homo sapiens_hsa000300.58426375
93Huntingtons disease_Homo sapiens_hsa050160.57908079
94Carbon metabolism_Homo sapiens_hsa012000.55887636
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53660934
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51735081
97Morphine addiction_Homo sapiens_hsa050320.51233314
98Alcoholism_Homo sapiens_hsa050340.50344229
99Notch signaling pathway_Homo sapiens_hsa043300.49921501
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49352963
101Taste transduction_Homo sapiens_hsa047420.47997572
102Serotonergic synapse_Homo sapiens_hsa047260.47932139
103GABAergic synapse_Homo sapiens_hsa047270.47772595
104Wnt signaling pathway_Homo sapiens_hsa043100.45275313
105Insulin secretion_Homo sapiens_hsa049110.43346872
106Arginine and proline metabolism_Homo sapiens_hsa003300.41192220
107Parkinsons disease_Homo sapiens_hsa050120.38771563
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38447841
109TGF-beta signaling pathway_Homo sapiens_hsa043500.38412469
110Fructose and mannose metabolism_Homo sapiens_hsa000510.37768328
111N-Glycan biosynthesis_Homo sapiens_hsa005100.37499001
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36166367
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35613838
114Steroid biosynthesis_Homo sapiens_hsa001000.32332229
115Metabolic pathways_Homo sapiens_hsa011000.31189476
116Bladder cancer_Homo sapiens_hsa052190.30078379
117Linoleic acid metabolism_Homo sapiens_hsa005910.29850750
118Small cell lung cancer_Homo sapiens_hsa052220.29590072
119Lysine degradation_Homo sapiens_hsa003100.29358054
120Glutathione metabolism_Homo sapiens_hsa004800.28211168
121Thyroid cancer_Homo sapiens_hsa052160.26793428
122Regulation of autophagy_Homo sapiens_hsa041400.26178301
123Tight junction_Homo sapiens_hsa045300.26156656
124Fatty acid elongation_Homo sapiens_hsa000620.24772212
125Pathways in cancer_Homo sapiens_hsa052000.22391067
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22040765
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.21970609
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21252288
129HIF-1 signaling pathway_Homo sapiens_hsa040660.21177712
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19446847
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18868993
132Melanoma_Homo sapiens_hsa052180.17743386
133Colorectal cancer_Homo sapiens_hsa052100.17341542
134Oxidative phosphorylation_Homo sapiens_hsa001900.16613672
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.16115890
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14515926
137Other glycan degradation_Homo sapiens_hsa005110.13075386
138Prostate cancer_Homo sapiens_hsa052150.11179321
139Arachidonic acid metabolism_Homo sapiens_hsa005900.10987376
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09262256
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08948386
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.08049519
143Ether lipid metabolism_Homo sapiens_hsa005650.06255778
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.06202416
145Renal cell carcinoma_Homo sapiens_hsa052110.05827103
146Vitamin digestion and absorption_Homo sapiens_hsa049770.05548714
147mTOR signaling pathway_Homo sapiens_hsa041500.05546671

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