TSACC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)6.75644505
2aminoglycoside antibiotic metabolic process (GO:0030647)6.46739090
3maintenance of protein location in nucleus (GO:0051457)6.18454535
4regulation of response to osmotic stress (GO:0047484)6.10102279
5negative regulation of epidermis development (GO:0045683)5.97621418
6somite rostral/caudal axis specification (GO:0032525)5.61843094
7protein localization to kinetochore (GO:0034501)5.57098737
8negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.56052296
9regulation of telomere maintenance via telomerase (GO:0032210)5.53004740
10regulation of nuclear cell cycle DNA replication (GO:0033262)5.46606869
11regulation of mammary gland epithelial cell proliferation (GO:0033599)5.36184447
12proteasome assembly (GO:0043248)5.29115334
13rRNA transcription (GO:0009303)5.25940591
14negative regulation of cell cycle G2/M phase transition (GO:1902750)5.14710502
15negative regulation of telomerase activity (GO:0051974)5.08387940
16negative regulation of epidermal cell differentiation (GO:0045605)5.06210742
17fusion of sperm to egg plasma membrane (GO:0007342)5.03230435
18protein localization to chromosome, centromeric region (GO:0071459)4.98266163
19rRNA methylation (GO:0031167)4.82348476
20negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.80544466
21mitotic sister chromatid segregation (GO:0000070)4.76572866
22regulation of MHC class I biosynthetic process (GO:0045343)4.73517602
23histone H4-K8 acetylation (GO:0043982)4.66282683
24histone H4-K5 acetylation (GO:0043981)4.66282683
25DNA double-strand break processing (GO:0000729)4.64955016
26histone H4-K12 acetylation (GO:0043983)4.64275865
27rRNA modification (GO:0000154)4.61321779
28muscle organ morphogenesis (GO:0048644)4.51493183
29microtubule severing (GO:0051013)4.46638716
30negative regulation of telomere maintenance (GO:0032205)4.36936997
31DNA replication-dependent nucleosome organization (GO:0034723)4.30071810
32DNA replication-dependent nucleosome assembly (GO:0006335)4.30071810
33heterochromatin organization (GO:0070828)4.19722263
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.18270062
35response to dietary excess (GO:0002021)4.15985122
36cytidine deamination (GO:0009972)4.15578761
37cytidine metabolic process (GO:0046087)4.15578761
38cytidine catabolic process (GO:0006216)4.15578761
39phenol-containing compound catabolic process (GO:0019336)4.15368702
40quinone metabolic process (GO:1901661)4.13939260
41regulation of microtubule-based movement (GO:0060632)4.03220120
42chromatin remodeling at centromere (GO:0031055)3.96948327
43regulation of apoptotic process involved in morphogenesis (GO:1902337)3.94717321
44cardiovascular system development (GO:0072358)3.93401842
45positive regulation of DNA-dependent DNA replication (GO:2000105)3.93085278
46ventricular system development (GO:0021591)3.93008527
47interferon-gamma production (GO:0032609)3.92939238
48histone exchange (GO:0043486)3.92421711
49nucleoside transmembrane transport (GO:1901642)3.91788938
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.88259422
51DNA replication checkpoint (GO:0000076)3.84530453
52protein polyglutamylation (GO:0018095)3.78890145
53sister chromatid segregation (GO:0000819)3.78683659
54regulation of translation in response to stress (GO:0043555)3.78134496
55coenzyme catabolic process (GO:0009109)3.72813585
56CENP-A containing nucleosome assembly (GO:0034080)3.72537848
57notochord development (GO:0030903)3.71631076
58chromatin assembly (GO:0031497)3.70947862
59ribosomal small subunit biogenesis (GO:0042274)3.65604897
60hormone catabolic process (GO:0042447)3.63861566
61pseudouridine synthesis (GO:0001522)3.59516413
62GDP-mannose metabolic process (GO:0019673)3.58147169
63ATP synthesis coupled proton transport (GO:0015986)3.56820371
64energy coupled proton transport, down electrochemical gradient (GO:0015985)3.56820371
65plasma membrane fusion (GO:0045026)3.56179177
66cullin deneddylation (GO:0010388)3.54238851
67nuclear pore complex assembly (GO:0051292)3.51174190
68ribosome biogenesis (GO:0042254)3.50131084
69regulation of telomerase activity (GO:0051972)3.45305553
70primitive streak formation (GO:0090009)3.45101065
71regulation of meiosis I (GO:0060631)3.45045821
72cell wall macromolecule catabolic process (GO:0016998)3.43221905
73cell wall macromolecule metabolic process (GO:0044036)3.43221905
74histone H4-K16 acetylation (GO:0043984)3.41973068
75multicellular organism reproduction (GO:0032504)3.41644353
76branching involved in mammary gland duct morphogenesis (GO:0060444)3.41348926
77sperm motility (GO:0030317)3.40084526
78protein complex biogenesis (GO:0070271)3.39035033
79cell fate commitment involved in formation of primary germ layer (GO:0060795)3.38049544
80chromosome condensation (GO:0030261)3.37898234
81replication fork processing (GO:0031297)3.37528400
82DNA damage response, detection of DNA damage (GO:0042769)3.35448665
83regulation of mitotic spindle checkpoint (GO:1903504)3.32123638
84regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32123638
85chaperone-mediated protein transport (GO:0072321)3.31713799
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31422540
87transcription from mitochondrial promoter (GO:0006390)3.29561857
88respiratory chain complex IV assembly (GO:0008535)3.29469788
89acrosome assembly (GO:0001675)3.28511635
90regulation of telomere maintenance (GO:0032204)3.26690974
91DNA catabolic process, exonucleolytic (GO:0000738)3.25696120
92mitochondrial respiratory chain complex assembly (GO:0033108)3.24176223
93transcription elongation from RNA polymerase III promoter (GO:0006385)3.19934145
94termination of RNA polymerase III transcription (GO:0006386)3.19934145
95sperm-egg recognition (GO:0035036)3.19777921
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19658286
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18500985
98NADH dehydrogenase complex assembly (GO:0010257)3.16928939
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16928939
100mitochondrial respiratory chain complex I assembly (GO:0032981)3.16928939
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16856167
102maintenance of protein localization in organelle (GO:0072595)3.16493589
103response to pheromone (GO:0019236)3.15770495
104intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.15109662
105regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.15096917
106formation of translation preinitiation complex (GO:0001731)3.14903708
107microtubule depolymerization (GO:0007019)3.13634621
108single strand break repair (GO:0000012)3.13210225
109centriole replication (GO:0007099)3.10745368
110protein deneddylation (GO:0000338)3.10588977
111piRNA metabolic process (GO:0034587)3.09319837
112nuclear pore organization (GO:0006999)3.08348006
113bone trabecula formation (GO:0060346)3.04958813
114mitochondrion distribution (GO:0048311)3.04812356
115telomere maintenance via semi-conservative replication (GO:0032201)3.03789141
116RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03647325
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03647325
118binding of sperm to zona pellucida (GO:0007339)3.03153250
119positive regulation of protein deacetylation (GO:0090312)3.02146585
120icosanoid secretion (GO:0032309)3.01895989
121arachidonic acid secretion (GO:0050482)3.01895989
122kinetochore assembly (GO:0051382)3.01083910
123regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00632457
124DNA packaging (GO:0006323)3.00605853
125cytochrome complex assembly (GO:0017004)3.00142691
126organic cation transport (GO:0015695)2.95549130
127spermatid development (GO:0007286)2.95392333
128ribonucleoprotein complex biogenesis (GO:0022613)2.95109126
129transepithelial transport (GO:0070633)2.94012748
130kinetochore organization (GO:0051383)2.93778321
131resolution of meiotic recombination intermediates (GO:0000712)2.92709684
132respiratory electron transport chain (GO:0022904)2.91808161
133spliceosomal snRNP assembly (GO:0000387)2.90763895
134motile cilium assembly (GO:0044458)2.90599725
135histone mRNA metabolic process (GO:0008334)2.89181123
136positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88052091
137regulation of centriole replication (GO:0046599)2.87777181
138pyrimidine ribonucleoside catabolic process (GO:0046133)2.87575538
139electron transport chain (GO:0022900)2.86009950
140recombinational repair (GO:0000725)2.85465897
141microtubule polymerization or depolymerization (GO:0031109)2.84915395
142double-strand break repair via homologous recombination (GO:0000724)2.84871092
143regulation of double-strand break repair (GO:2000779)2.84649143
144nucleoside transport (GO:0015858)2.84561155
145acrosome reaction (GO:0007340)2.84428115
146anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83934544
147cellular modified amino acid catabolic process (GO:0042219)2.83501778
148histone H2A acetylation (GO:0043968)2.82318811
149male meiosis (GO:0007140)2.80748872
150DNA replication-independent nucleosome assembly (GO:0006336)2.80731391
151DNA replication-independent nucleosome organization (GO:0034724)2.80731391
152negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.80471627
153negative regulation of ligase activity (GO:0051352)2.80471627
154synapsis (GO:0007129)2.80091888
155DNA strand elongation involved in DNA replication (GO:0006271)2.79598608
156maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75626852
157mannosylation (GO:0097502)2.70768512
158postreplication repair (GO:0006301)2.70189044
159somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69346731
160somatic hypermutation of immunoglobulin genes (GO:0016446)2.69346731
161DNA strand elongation (GO:0022616)2.68939825
162regulation of cellular amino acid metabolic process (GO:0006521)2.68823353
163purine nucleobase biosynthetic process (GO:0009113)2.67709967
164telomere maintenance via recombination (GO:0000722)2.65094672
165DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63327366
166peptidyl-histidine modification (GO:0018202)2.63046526
167signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.61635845
168signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.61635845
169signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61635845
170water-soluble vitamin biosynthetic process (GO:0042364)2.61555394
171protein-cofactor linkage (GO:0018065)2.61004325
172L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60721951
173negative regulation of DNA-dependent DNA replication (GO:2000104)2.60664567
174negative regulation of mitotic sister chromatid separation (GO:2000816)2.59772286
175negative regulation of sister chromatid segregation (GO:0033046)2.59772286
176negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.59772286
177negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.59772286
178negative regulation of mitotic sister chromatid segregation (GO:0033048)2.59772286
179DNA methylation involved in gamete generation (GO:0043046)2.57830893
180protein neddylation (GO:0045116)2.57003620
181negative regulation of chromosome segregation (GO:0051985)2.56362619
182signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.56350007
183intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.56350007
184nucleobase biosynthetic process (GO:0046112)2.56206816
185protein K6-linked ubiquitination (GO:0085020)2.54814375
186polyketide metabolic process (GO:0030638)10.0445182
187doxorubicin metabolic process (GO:0044598)10.0445182
188daunorubicin metabolic process (GO:0044597)10.0445182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.89224523
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.87066689
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.87066689
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.87066689
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.00909382
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.08447255
7E2F7_22180533_ChIP-Seq_HELA_Human3.86739683
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.02987722
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.00891333
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.99947305
11ZNF274_21170338_ChIP-Seq_K562_Hela2.75540393
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66841406
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.60920268
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.56206052
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.29062537
16IRF1_19129219_ChIP-ChIP_H3396_Human2.27304482
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.26316745
18ELK1_19687146_ChIP-ChIP_HELA_Human2.26221858
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.24800128
20VDR_22108803_ChIP-Seq_LS180_Human2.22327706
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13464976
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13126177
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08138679
24TCF3_18692474_ChIP-Seq_MESCs_Mouse2.07671945
25FUS_26573619_Chip-Seq_HEK293_Human2.03436206
26NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.02865770
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02302409
28POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.87361069
29TCF3_18692474_ChIP-Seq_MEFs_Mouse1.83201521
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.82957587
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82251806
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.81898754
33EWS_26573619_Chip-Seq_HEK293_Human1.80742276
34MYC_18940864_ChIP-ChIP_HL60_Human1.80718892
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79501323
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78995265
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78141584
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76464727
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.76265960
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.74595896
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.74571092
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.73631489
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70834895
44IGF1R_20145208_ChIP-Seq_DFB_Human1.64859375
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63701891
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.60005081
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59801031
48DCP1A_22483619_ChIP-Seq_HELA_Human1.59541602
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56483905
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55053935
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53162070
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52589954
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51517564
54NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.51293804
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50497836
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50363440
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49837151
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48037552
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47758283
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47595186
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47587116
62P300_19829295_ChIP-Seq_ESCs_Human1.45741760
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44264831
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42756087
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42744900
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41985218
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40664164
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.40634140
69POU5F1_16518401_ChIP-PET_MESCs_Mouse1.40599575
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40360474
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39997295
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39179557
73NANOG_18692474_ChIP-Seq_MEFs_Mouse1.38139514
74POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.37413720
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36620386
76E2F1_17053090_ChIP-ChIP_MCF-7_Human1.35294215
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33450273
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.32523341
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29633646
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28732400
81TAF15_26573619_Chip-Seq_HEK293_Human1.28412087
82TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.27919576
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27717322
84NANOG_18692474_ChIP-Seq_MESCs_Mouse1.27460793
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26498217
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24302294
87FOXP3_21729870_ChIP-Seq_TREG_Human1.23357670
88ER_23166858_ChIP-Seq_MCF-7_Human1.20304591
89SCL_19346495_ChIP-Seq_HPC-7_Human1.16987050
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.16035060
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15891504
92GABP_17652178_ChIP-ChIP_JURKAT_Human1.15482101
93PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.15226374
94TP53_22573176_ChIP-Seq_HFKS_Human1.15103825
95KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13394858
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12994152
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10133352
98YY1_22570637_ChIP-Seq_MALME-3M_Human1.09699183
99SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09533976
100ETS1_20019798_ChIP-Seq_JURKAT_Human1.09111819
101E2F1_21310950_ChIP-Seq_MCF-7_Human1.08357768
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07508787
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06738212
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04252840
105CBP_20019798_ChIP-Seq_JUKART_Human1.04252840
106SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02240406
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01602065
108OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00126414
109GBX2_23144817_ChIP-Seq_PC3_Human0.98931519
110BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98675517
111E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98372173
112HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98264470
113CBX2_27304074_Chip-Seq_ESCs_Mouse0.97423637
114XRN2_22483619_ChIP-Seq_HELA_Human0.97289160
115KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97018262
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95622765
117FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95592573
118FOXA1_25329375_ChIP-Seq_VCAP_Human0.95592573
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94938310
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94544223
121HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94286686
122NANOG_16518401_ChIP-PET_MESCs_Mouse0.93034748
123NCOR_22424771_ChIP-Seq_293T_Human0.92787308
124ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92172797
125NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91567868
126HOXB7_26014856_ChIP-Seq_BT474_Human0.91087708
127NANOG_16153702_ChIP-ChIP_HESCs_Human0.90532490
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.88855195
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88192297
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88048123
131ELK1_22589737_ChIP-Seq_MCF10A_Human0.87808400
132VDR_23849224_ChIP-Seq_CD4+_Human0.87628807
133ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87129495
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86759448
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86759448
136RBPJ_21746931_ChIP-Seq_IB4_Human0.86474579
137NANOG_21062744_ChIP-ChIP_HESCs_Human0.84802225
138SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83446323
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.83438373
140STAT3_18555785_ChIP-Seq_MESCs_Mouse0.81968917
141GABP_19822575_ChIP-Seq_HepG2_Human0.81047362
142TTF2_22483619_ChIP-Seq_HELA_Human0.80700947
143GATA1_26923725_Chip-Seq_HPCs_Mouse0.79853432
144HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.79424185
145ESET_19884257_ChIP-Seq_ESCs_Mouse0.79331442
146SPI1_26923725_Chip-Seq_HPCs_Mouse0.78666896
147CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.78226794
148RNF2_27304074_Chip-Seq_NSC_Mouse0.76747437
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75029890
150SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.74814110
151SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74554883
152KAP1_27257070_Chip-Seq_ESCs_Mouse0.74403205
153CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74109088
154TP53_22127205_ChIP-Seq_IMR90_Human0.73158793
155MYCN_18555785_ChIP-Seq_MESCs_Mouse0.72161285
156KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69701180
157BCOR_27268052_Chip-Seq_Bcells_Human0.69285183
158STAT1_20625510_ChIP-Seq_HELA_Human0.69250729
159KDM5A_27292631_Chip-Seq_BREAST_Human0.69052985
160SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.67830176
161NCOR1_26117541_ChIP-Seq_K562_Human0.67742987
162KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.67362758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.15836627
2MP0006292_abnormal_olfactory_placode4.66317794
3MP0005410_abnormal_fertilization4.45831791
4MP0002254_reproductive_system_inflammat3.97686151
5MP0004264_abnormal_extraembryonic_tissu3.97029389
6MP0005075_abnormal_melanosome_morpholog3.57823170
7MP0008057_abnormal_DNA_replication3.39124796
8MP0005499_abnormal_olfactory_system3.18334444
9MP0005394_taste/olfaction_phenotype3.18334444
10MP0003890_abnormal_embryonic-extraembry3.06920444
11MP0004957_abnormal_blastocyst_morpholog3.01813377
12MP0003718_maternal_effect2.55582087
13MP0002938_white_spotting2.52180966
14MP0006035_abnormal_mitochondrial_morpho2.51481383
15MP0002653_abnormal_ependyma_morphology2.46161694
16MP0002332_abnormal_exercise_endurance2.40291554
17MP0003122_maternal_imprinting2.28646951
18MP0001529_abnormal_vocalization2.17193477
19MP0004858_abnormal_nervous_system2.11837431
20MP0002102_abnormal_ear_morphology2.09868181
21MP0003880_abnormal_central_pattern2.08224200
22MP0005257_abnormal_intraocular_pressure2.07463089
23MP0002234_abnormal_pharynx_morphology2.06950228
24MP0003121_genomic_imprinting1.98145264
25MP0003195_calcinosis1.88158111
26MP0003938_abnormal_ear_development1.87015368
27MP0000678_abnormal_parathyroid_gland1.83010116
28MP0001293_anophthalmia1.76886084
29MP0006082_CNS_inflammation1.75608398
30MP0005551_abnormal_eye_electrophysiolog1.71440591
31MP0002736_abnormal_nociception_after1.70743132
32MP0002277_abnormal_respiratory_mucosa1.66914747
33MP0003077_abnormal_cell_cycle1.66151897
34MP0003698_abnormal_male_reproductive1.65965733
35MP0009697_abnormal_copulation1.65073731
36MP0001929_abnormal_gametogenesis1.62365988
37MP0003646_muscle_fatigue1.58513902
38MP0006072_abnormal_retinal_apoptosis1.56987785
39MP0005380_embryogenesis_phenotype1.56160482
40MP0001672_abnormal_embryogenesis/_devel1.56160482
41MP0000372_irregular_coat_pigmentation1.54214872
42MP0000566_synostosis1.53441605
43MP0001968_abnormal_touch/_nociception1.48591325
44MP0010094_abnormal_chromosome_stability1.48542292
45MP0004133_heterotaxia1.48519899
46MP0002127_abnormal_cardiovascular_syste1.47037050
47MP0004381_abnormal_hair_follicle1.46940700
48MP0008789_abnormal_olfactory_epithelium1.42339524
49MP0002092_abnormal_eye_morphology1.40618342
50MP0002088_abnormal_embryonic_growth/wei1.38855692
51MP0003984_embryonic_growth_retardation1.38671331
52MP0002932_abnormal_joint_morphology1.37934648
53MP0004147_increased_porphyrin_level1.37140055
54MP0000350_abnormal_cell_proliferation1.36893192
55MP0000049_abnormal_middle_ear1.36523649
56MP0002132_abnormal_respiratory_system1.35216084
57MP0000762_abnormal_tongue_morphology1.33901387
58MP0002396_abnormal_hematopoietic_system1.32267207
59MP0003111_abnormal_nucleus_morphology1.30162859
60MP0000631_abnormal_neuroendocrine_gland1.28262896
61MP0005266_abnormal_metabolism1.25189612
62MP0001145_abnormal_male_reproductive1.22226783
63MP0010030_abnormal_orbit_morphology1.19968974
64MP0003183_abnormal_peptide_metabolism1.19569178
65MP0001348_abnormal_lacrimal_gland1.18919686
66MP0003283_abnormal_digestive_organ1.17565425
67MP0005377_hearing/vestibular/ear_phenot1.16281751
68MP0003878_abnormal_ear_physiology1.16281751
69MP0002210_abnormal_sex_determination1.15279241
70MP0001188_hyperpigmentation1.15228747
71MP0002160_abnormal_reproductive_system1.15023602
72MP0005379_endocrine/exocrine_gland_phen1.14396099
73MP0003315_abnormal_perineum_morphology1.14044322
74MP0008995_early_reproductive_senescence1.13922592
75MP0002233_abnormal_nose_morphology1.13356717
76MP0001919_abnormal_reproductive_system1.09220829
77MP0000313_abnormal_cell_death1.07567682
78MP0004043_abnormal_pH_regulation1.07385597
79MP0002085_abnormal_embryonic_tissue1.06537651
80MP0008007_abnormal_cellular_replicative1.06012060
81MP0010352_gastrointestinal_tract_polyps1.05755093
82MP0002114_abnormal_axial_skeleton1.05570364
83MP0001849_ear_inflammation1.05412704
84MP0005423_abnormal_somatic_nervous1.05352107
85MP0003123_paternal_imprinting1.04586381
86MP0001485_abnormal_pinna_reflex1.04535686
87MP0006036_abnormal_mitochondrial_physio1.03641348
88MP0002086_abnormal_extraembryonic_tissu1.02945411
89MP0003806_abnormal_nucleotide_metabolis1.02889918
90MP0008932_abnormal_embryonic_tissue1.02232904
91MP0005391_vision/eye_phenotype1.01732671
92MP0005395_other_phenotype1.01295678
93MP0002822_catalepsy1.00519941
94MP0003937_abnormal_limbs/digits/tail_de1.00131903
95MP0003787_abnormal_imprinting0.98888643
96MP0002837_dystrophic_cardiac_calcinosis0.96671123
97MP0009745_abnormal_behavioral_response0.96217260
98MP0005645_abnormal_hypothalamus_physiol0.96174120
99MP0006276_abnormal_autonomic_nervous0.95420655
100MP0008058_abnormal_DNA_repair0.94997269
101MP0008877_abnormal_DNA_methylation0.93367169
102MP0002095_abnormal_skin_pigmentation0.92453191
103MP0003567_abnormal_fetal_cardiomyocyte0.92092726
104MP0001486_abnormal_startle_reflex0.92086570
105MP0005389_reproductive_system_phenotype0.91743059
106MP0005408_hypopigmentation0.91238898
107MP0002084_abnormal_developmental_patter0.90975320
108MP0002161_abnormal_fertility/fecundity0.89686454
109MP0000490_abnormal_crypts_of0.88738986
110MP0002735_abnormal_chemical_nociception0.88457796
111MP0002163_abnormal_gland_morphology0.87131983
112MP0000432_abnormal_head_morphology0.86898329
113MP0004885_abnormal_endolymph0.85932687
114MP0001764_abnormal_homeostasis0.85431408
115MP0003693_abnormal_embryo_hatching0.85051505
116MP0003786_premature_aging0.84975479
117MP0002638_abnormal_pupillary_reflex0.84390672
118MP0009046_muscle_twitch0.82942946
119MP0008770_decreased_survivor_rate0.82392774
120MP0002970_abnormal_white_adipose0.81137312
121MP0000026_abnormal_inner_ear0.80993265
122MP0003136_yellow_coat_color0.80548434
123MP0001730_embryonic_growth_arrest0.79073263
124MP0008961_abnormal_basal_metabolism0.79041188
125MP0002752_abnormal_somatic_nervous0.78574341
126MP0000653_abnormal_sex_gland0.77642125
127MP0002282_abnormal_trachea_morphology0.77541989
128MP0003137_abnormal_impulse_conducting0.77481530
129MP0005171_absent_coat_pigmentation0.77276792
130MP0001119_abnormal_female_reproductive0.77203745
131MP0000647_abnormal_sebaceous_gland0.76929680
132MP0005174_abnormal_tail_pigmentation0.76832175
133MP0005195_abnormal_posterior_eye0.76728127
134MP0008872_abnormal_physiological_respon0.76665151
135MP0001905_abnormal_dopamine_level0.74835308
136MP0001697_abnormal_embryo_size0.74522449
137MP0005670_abnormal_white_adipose0.74484903
138MP0002080_prenatal_lethality0.72157655
139MP0003186_abnormal_redox_activity0.72141471
140MP0003119_abnormal_digestive_system0.71729604
141MP0003950_abnormal_plasma_membrane0.71590722
142MP0003705_abnormal_hypodermis_morpholog0.71101379
143MP0000749_muscle_degeneration0.70685369
144MP0002751_abnormal_autonomic_nervous0.69931112
145MP0003755_abnormal_palate_morphology0.69863652
146MP0005248_abnormal_Harderian_gland0.69617306
147MP0003935_abnormal_craniofacial_develop0.69571718
148MP0000358_abnormal_cell_content/0.68445884
149MP0005253_abnormal_eye_physiology0.67649410
150MP0002098_abnormal_vibrissa_morphology0.63101384
151MP0002249_abnormal_larynx_morphology0.62781838
152MP0004197_abnormal_fetal_growth/weight/0.62406176
153MP0002019_abnormal_tumor_incidence0.59818608
154MP0000428_abnormal_craniofacial_morphol0.58064218
155MP0005508_abnormal_skeleton_morphology0.57956446
156MP0002116_abnormal_craniofacial_bone0.57169142

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.99481791
2Hypochromic microcytic anemia (HP:0004840)5.54117322
3Rib fusion (HP:0000902)4.84842586
4Multiple enchondromatosis (HP:0005701)4.84797546
5Hepatoblastoma (HP:0002884)4.64947144
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.31032154
7Abnormality of the lower motor neuron (HP:0002366)4.16946676
8Nephroblastoma (Wilms tumor) (HP:0002667)4.06175663
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78927125
10Embryonal renal neoplasm (HP:0011794)3.74373938
11Acute necrotizing encephalopathy (HP:0006965)3.63792312
12Birth length less than 3rd percentile (HP:0003561)3.63562071
13Partial duplication of thumb phalanx (HP:0009944)3.59948312
14Anomalous pulmonary venous return (HP:0010772)3.58413602
15Ependymoma (HP:0002888)3.57652867
16Rectovaginal fistula (HP:0000143)3.51712340
17Rectal fistula (HP:0100590)3.51712340
18Testicular atrophy (HP:0000029)3.40890502
19Chromsome breakage (HP:0040012)3.34492872
20Abnormal lung lobation (HP:0002101)3.33683343
21Nasal polyposis (HP:0100582)3.33093077
22Acute encephalopathy (HP:0006846)3.32676222
23Neoplasm of striated muscle (HP:0009728)3.30127804
243-Methylglutaconic aciduria (HP:0003535)3.27405163
25Abnormal mitochondria in muscle tissue (HP:0008316)3.21678823
26Hypoplasia of the fovea (HP:0007750)3.21041041
27Aplasia/Hypoplasia of the fovea (HP:0008060)3.21041041
28Rhabdomyosarcoma (HP:0002859)3.16013382
29Mitochondrial inheritance (HP:0001427)3.13441356
30Bifid tongue (HP:0010297)3.10551360
31Supernumerary spleens (HP:0009799)3.08801130
32Partial duplication of the phalanx of hand (HP:0009999)3.08307297
33Dynein arm defect of respiratory motile cilia (HP:0012255)3.07309898
34Absent/shortened dynein arms (HP:0200106)3.07309898
35Intestinal fistula (HP:0100819)3.03264946
36Increased CSF lactate (HP:0002490)3.03081505
37Fused cervical vertebrae (HP:0002949)3.01221509
38Progressive macrocephaly (HP:0004481)3.00662171
39Abnormality of the pulmonary veins (HP:0011718)2.99904063
40Nephronophthisis (HP:0000090)2.99423838
41Vaginal fistula (HP:0004320)2.97715708
42Ragged-red muscle fibers (HP:0003200)2.97568480
43Pancreatic cysts (HP:0001737)2.97342126
44Amyotrophic lateral sclerosis (HP:0007354)2.96131852
45Sensory axonal neuropathy (HP:0003390)2.95620706
46Impulsivity (HP:0100710)2.92963764
47Abnormality of the labia minora (HP:0012880)2.89687873
48Hepatocellular necrosis (HP:0001404)2.77487368
49Abnormality of the salivary glands (HP:0010286)2.77123660
50Hypochromic anemia (HP:0001931)2.75487909
51Reduced antithrombin III activity (HP:0001976)2.72990295
52Aplasia/hypoplasia of the humerus (HP:0006507)2.72753803
53Abnormal respiratory motile cilium physiology (HP:0012261)2.67585698
54Abnormality of the nasal mucosa (HP:0000433)2.65713598
55Meckel diverticulum (HP:0002245)2.64879564
56Hyperinsulinemic hypoglycemia (HP:0000825)2.64562421
57Trismus (HP:0000211)2.63444102
58Increased hepatocellular lipid droplets (HP:0006565)2.62991608
59Abnormality of the phalanges of the hallux (HP:0010057)2.61916372
60Exertional dyspnea (HP:0002875)2.57403449
61Microvesicular hepatic steatosis (HP:0001414)2.55267412
62Colon cancer (HP:0003003)2.54523458
63Progressive muscle weakness (HP:0003323)2.54093837
64Short humerus (HP:0005792)2.54007126
65Abnormality of the ileum (HP:0001549)2.52852661
66Abnormality of the fovea (HP:0000493)2.52276216
67Renal Fanconi syndrome (HP:0001994)2.50881167
68Abnormality of chromosome stability (HP:0003220)2.49896759
69Hepatic necrosis (HP:0002605)2.49314485
70Lipid accumulation in hepatocytes (HP:0006561)2.48511120
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.46040576
72Horizontal nystagmus (HP:0000666)2.45191340
73Pendular nystagmus (HP:0012043)2.43730116
74Congenital stationary night blindness (HP:0007642)2.42712244
75Hyperventilation (HP:0002883)2.41774877
76Cerebral edema (HP:0002181)2.41557707
77Nasolacrimal duct obstruction (HP:0000579)2.38677381
78True hermaphroditism (HP:0010459)2.38080101
79Optic nerve hypoplasia (HP:0000609)2.37526291
80Pancreatic fibrosis (HP:0100732)2.37388916
81Type I transferrin isoform profile (HP:0003642)2.35888427
82Septo-optic dysplasia (HP:0100842)2.34441230
83Abnormal ciliary motility (HP:0012262)2.33017036
84Severe visual impairment (HP:0001141)2.32914348
85Abnormal cartilage morphology (HP:0002763)2.31138490
86Abnormality of the renal medulla (HP:0100957)2.30631566
87Chronic bronchitis (HP:0004469)2.30559114
88Microretrognathia (HP:0000308)2.29598927
89Hypothermia (HP:0002045)2.28083982
90Progressive external ophthalmoplegia (HP:0000590)2.27991436
91Preauricular skin tag (HP:0000384)2.27766518
92Aplasia/Hypoplasia of the macula (HP:0008059)2.23883557
93Methylmalonic acidemia (HP:0002912)2.23195045
94Abnormal respiratory epithelium morphology (HP:0012253)2.22204410
95Abnormal respiratory motile cilium morphology (HP:0005938)2.22204410
96Dyschromatopsia (HP:0007641)2.21636261
97Astrocytoma (HP:0009592)2.21573249
98Abnormality of the astrocytes (HP:0100707)2.21573249
99Increased serum lactate (HP:0002151)2.21249335
100Chronic hepatic failure (HP:0100626)2.20202212
101Increased serum pyruvate (HP:0003542)2.19792003
102Abnormality of glycolysis (HP:0004366)2.19792003
103Optic disc pallor (HP:0000543)2.16989900
104Periauricular skin pits (HP:0100277)2.15671015
105Preauricular pit (HP:0004467)2.15671015
106Duplication of thumb phalanx (HP:0009942)2.15663683
107Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14865259
108Abnormality of midbrain morphology (HP:0002418)2.13415999
109Molar tooth sign on MRI (HP:0002419)2.13415999
110Duodenal stenosis (HP:0100867)2.13396908
111Small intestinal stenosis (HP:0012848)2.13396908
112Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11200692
113Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11200692
114Aplasia/Hypoplasia affecting the retina (HP:0008061)2.11134178
115Facial cleft (HP:0002006)2.10502868
116Abnormal rod and cone electroretinograms (HP:0008323)2.09343092
117Generalized hypotonia (HP:0001290)2.08006537
118Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07568675
119Aplastic anemia (HP:0001915)2.06196398
120Methylmalonic aciduria (HP:0012120)2.06074850
121Ectopic kidney (HP:0000086)2.04448631
122Rhinitis (HP:0012384)2.03131628
123Abnormality of the preputium (HP:0100587)2.03115214
124Glossoptosis (HP:0000162)2.02162545
125Sclerocornea (HP:0000647)2.02093662
126Medial flaring of the eyebrow (HP:0010747)2.01854476
127Villous atrophy (HP:0011473)2.01167353
128Abnormality of small intestinal villus morphology (HP:0011472)2.01167353
129Intestinal atresia (HP:0011100)2.00629163
130Lactic acidosis (HP:0003128)1.99639260
131Abnormality of the duodenum (HP:0002246)1.99256876
132Abnormality of macular pigmentation (HP:0008002)1.99180877
133Embryonal neoplasm (HP:0002898)1.96776810
134Tongue fasciculations (HP:0001308)1.95837941
135Prominent occiput (HP:0000269)1.95185209
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.95102203
137Triphalangeal thumb (HP:0001199)1.94427459
138Bony spicule pigmentary retinopathy (HP:0007737)1.92798333
139Type II lissencephaly (HP:0007260)1.92761383
140Volvulus (HP:0002580)1.92700312
141Skin tags (HP:0010609)1.92254488
142Aplasia/hypoplasia of the uterus (HP:0008684)1.91174922
143Sloping forehead (HP:0000340)1.91037296
144Premature ovarian failure (HP:0008209)1.89980464
145Shawl scrotum (HP:0000049)1.89611290
146Reticulocytopenia (HP:0001896)1.87905713
147Combined immunodeficiency (HP:0005387)1.87152263
148Abnormality of the pubic bones (HP:0003172)1.86316488
149Cheilitis (HP:0100825)1.85406142
150Abnormal number of erythroid precursors (HP:0012131)1.84151993
151Absent septum pellucidum (HP:0001331)1.84060324
152Abnormality of the pons (HP:0007361)1.83795655
153Hypoplasia of the pons (HP:0012110)1.81825921
154Absent thumb (HP:0009777)1.80779349
155Anencephaly (HP:0002323)1.78411821
156Patellar aplasia (HP:0006443)1.77915464
157Esophageal atresia (HP:0002032)1.77781422
158Abnormality of alanine metabolism (HP:0010916)1.77642440
159Hyperalaninemia (HP:0003348)1.77642440
160Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77642440
161Abnormality of serum amino acid levels (HP:0003112)1.77296432
162Abnormal protein glycosylation (HP:0012346)1.77284352
163Abnormal glycosylation (HP:0012345)1.77284352
164Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77284352
165Abnormal protein N-linked glycosylation (HP:0012347)1.77284352
166Gastrointestinal atresia (HP:0002589)1.76871831
167Small hand (HP:0200055)1.76694486
168Aplasia/Hypoplasia of the tongue (HP:0010295)1.76388200
169Preaxial hand polydactyly (HP:0001177)1.75234506
170Retinal dysplasia (HP:0007973)1.74946255
171Abnormality of urine glucose concentration (HP:0011016)1.73057810
172Glycosuria (HP:0003076)1.73057810
173Respiratory failure (HP:0002878)1.72509257
174Attenuation of retinal blood vessels (HP:0007843)1.71843337
175Abnormality of the carotid arteries (HP:0005344)1.71567472
176Lissencephaly (HP:0001339)1.71497307
177Postaxial foot polydactyly (HP:0001830)1.69828859
178Leukodystrophy (HP:0002415)1.69803459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.76675291
2GRK55.38133466
3GRK64.16806481
4ERN13.84706254
5ADRBK23.78810914
6GRK13.17611846
7PNCK3.14394722
8CSF1R2.97485858
9PLK42.93002498
10BMPR1B2.86673154
11GRK72.75184369
12ZAK2.67983012
13VRK22.66981201
14TTK2.63190238
15TGFBR22.44625801
16WNK32.35818700
17TSSK62.31642869
18TYRO32.20760119
19MAPK72.19687418
20MATK2.18209580
21TNIK2.12010958
22MAP4K22.10567023
23STK102.08247161
24WNK12.06966714
25MOS2.00645874
26PDK41.87130430
27PDK31.87130430
28TLK11.84752350
29STK38L1.84703093
30PLK31.74701756
31MKNK21.66055375
32NUAK11.65099507
33ACVR1B1.62627143
34CASK1.60643689
35FRK1.59952528
36PRKG21.58523672
37CDK71.52237090
38PBK1.47043924
39NME11.45001556
40CHEK21.42943901
41TAF11.39546263
42TRIM281.35567247
43BRSK11.34421435
44MARK11.29164357
45PLK21.27025890
46PLK11.25340628
47WEE11.25018377
48MARK21.22988206
49MAP2K61.22745410
50PAK41.21305251
51NTRK11.21217622
52MAPK131.19710353
53NEK11.18337547
54MAP3K121.16769687
55BUB11.13904413
56CAMK41.13614826
57PDK21.12840769
58ADRBK11.08499094
59EPHA21.06335100
60INSRR1.02760606
61EIF2AK31.02649404
62CCNB11.01304296
63HIPK20.99977632
64NEK20.96586712
65SRPK10.94861052
66EIF2AK20.93981241
67EPHA40.93392400
68RPS6KA40.91813996
69EIF2AK10.89676210
70MAP2K40.89649945
71CHEK10.89117835
72CDC70.87824607
73TESK10.83820678
74ERBB30.83615616
75ATR0.79000451
76ICK0.77049629
77CLK10.74919435
78TGFBR10.72991372
79OXSR10.70323796
80BCR0.67181191
81PRKCG0.66946632
82CSNK1G10.64482755
83RPS6KA50.64145534
84AURKA0.63273177
85PINK10.62596228
86CSNK1G20.62029776
87PRKCE0.61489806
88MAP3K40.58756264
89CSK0.57592191
90AKT30.56938989
91AKT20.55063297
92STK390.54943194
93BRD40.54588247
94MUSK0.53254482
95CSNK1G30.52573088
96NLK0.52251260
97CAMK1G0.51863669
98PAK10.50601130
99PKN10.50221435
100MAPK120.49750951
101DYRK30.49074790
102CDK80.47699696
103WNK40.47071400
104ABL20.46961357
105BRAF0.43852569
106RPS6KB20.43827730
107IKBKB0.42673554
108CDK20.42668271
109PASK0.42354747
110MAPKAPK50.41063640
111MKNK10.40766509
112CDK30.40757063
113CDK90.40585469
114CAMKK20.39685501
115CSNK1A1L0.39460557
116ATM0.39318120
117AURKB0.39271603
118CSNK1A10.38408426
119MARK30.37831152
120NTRK30.37388938
121TESK20.37007974
122MAPK150.36301057
123MAP2K70.36056288
124BCKDK0.35502382
125BRSK20.35235729
126STK160.35227048
127MAP3K100.34658625
128FGFR30.34412826
129DYRK20.34054262
130PRKCD0.33978408
131VRK10.33529583
132TNK20.33367248
133DAPK20.33174321
134MST40.32922449
135IGF1R0.32010561
136PRKCI0.31888358
137PRKD20.31452527
138ALK0.31199543
139STK30.30682001
140MAP3K70.30533571
141DYRK1B0.30381413
142MAPK40.29027300
143CSNK1E0.25353194
144YES10.25049255
145NME20.24502603
146MTOR0.21858946
147CDK40.21786949
148CDK10.21688683
149CDK190.21043611
150ITK0.20029189
151PRKACB0.19109258
152CSNK2A10.18840881
153PDK10.17804811
154CDK150.15969937
155CDK11A0.15126433
156PRKACA0.14965882
157GSK3B0.14868966
158KIT0.13581575
159MAPK10.13410641
160STK380.12992095
161PIM10.12900408
162DYRK1A0.12639374
163PIM20.12110339
164MAPKAPK30.11946174
165GSK3A0.11813573
166CSNK2A20.11366792
167CDK180.11277489

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.11985026
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.68358277
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.38846593
4Fructose and mannose metabolism_Homo sapiens_hsa000513.35246157
5Ribosome_Homo sapiens_hsa030103.16894606
6Arachidonic acid metabolism_Homo sapiens_hsa005903.09034273
7Linoleic acid metabolism_Homo sapiens_hsa005913.03673478
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.84771061
9Protein export_Homo sapiens_hsa030602.37266749
10DNA replication_Homo sapiens_hsa030302.36153340
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29726248
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.29175382
13Fanconi anemia pathway_Homo sapiens_hsa034602.28623587
14RNA transport_Homo sapiens_hsa030132.11547796
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03386211
16Mismatch repair_Homo sapiens_hsa034302.00801669
17Galactose metabolism_Homo sapiens_hsa000521.96808877
18Basal transcription factors_Homo sapiens_hsa030221.95760282
19Homologous recombination_Homo sapiens_hsa034401.93188109
20Spliceosome_Homo sapiens_hsa030401.80041963
21RNA polymerase_Homo sapiens_hsa030201.72290216
22RNA degradation_Homo sapiens_hsa030181.69644832
23Propanoate metabolism_Homo sapiens_hsa006401.62935707
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60047880
25Ether lipid metabolism_Homo sapiens_hsa005651.55978875
26mRNA surveillance pathway_Homo sapiens_hsa030151.45623344
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44294717
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40663321
29Pyrimidine metabolism_Homo sapiens_hsa002401.39142786
30Phototransduction_Homo sapiens_hsa047441.37469812
31Base excision repair_Homo sapiens_hsa034101.31351011
32Butanoate metabolism_Homo sapiens_hsa006501.26955277
33Nitrogen metabolism_Homo sapiens_hsa009101.25678766
34Cell cycle_Homo sapiens_hsa041101.25178386
35Non-homologous end-joining_Homo sapiens_hsa034501.17336691
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15508445
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14112169
38Chemical carcinogenesis_Homo sapiens_hsa052041.10769593
39Proteasome_Homo sapiens_hsa030501.08993753
40One carbon pool by folate_Homo sapiens_hsa006701.05687635
41Sulfur relay system_Homo sapiens_hsa041221.02044010
42Steroid biosynthesis_Homo sapiens_hsa001001.01364982
43Folate biosynthesis_Homo sapiens_hsa007900.99065327
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97598301
45Thyroid cancer_Homo sapiens_hsa052160.96024336
46Fatty acid elongation_Homo sapiens_hsa000620.94933801
47Pentose phosphate pathway_Homo sapiens_hsa000300.94390016
48Other glycan degradation_Homo sapiens_hsa005110.93596444
49Nucleotide excision repair_Homo sapiens_hsa034200.93071786
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.91336247
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86286176
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84685724
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83628702
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82585574
55Arginine and proline metabolism_Homo sapiens_hsa003300.81992077
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80320060
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79629003
58Peroxisome_Homo sapiens_hsa041460.75684423
59p53 signaling pathway_Homo sapiens_hsa041150.75358561
60beta-Alanine metabolism_Homo sapiens_hsa004100.75031148
61Nicotine addiction_Homo sapiens_hsa050330.74140563
62Purine metabolism_Homo sapiens_hsa002300.74047428
63Olfactory transduction_Homo sapiens_hsa047400.73561926
64Huntingtons disease_Homo sapiens_hsa050160.73341722
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70994821
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70312894
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69193464
68Ovarian steroidogenesis_Homo sapiens_hsa049130.65858448
69Herpes simplex infection_Homo sapiens_hsa051680.64670353
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.63764176
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62954103
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.62408252
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62041114
74Metabolic pathways_Homo sapiens_hsa011000.60287072
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.59970443
76Fatty acid degradation_Homo sapiens_hsa000710.59131864
77Selenocompound metabolism_Homo sapiens_hsa004500.56409952
78Tyrosine metabolism_Homo sapiens_hsa003500.56267859
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.55146394
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54865375
81Oxidative phosphorylation_Homo sapiens_hsa001900.53623346
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53563793
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.52979849
84Glutathione metabolism_Homo sapiens_hsa004800.52277411
85Parkinsons disease_Homo sapiens_hsa050120.52109268
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50451166
87Caffeine metabolism_Homo sapiens_hsa002320.50109701
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49491267
89Fatty acid metabolism_Homo sapiens_hsa012120.48818798
90Inositol phosphate metabolism_Homo sapiens_hsa005620.45739587
91African trypanosomiasis_Homo sapiens_hsa051430.45351131
92Carbon metabolism_Homo sapiens_hsa012000.44957523
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.43401052
94Hedgehog signaling pathway_Homo sapiens_hsa043400.42951606
95Basal cell carcinoma_Homo sapiens_hsa052170.42177710
96Vitamin digestion and absorption_Homo sapiens_hsa049770.41193424
97Fatty acid biosynthesis_Homo sapiens_hsa000610.40418976
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39213059
99mTOR signaling pathway_Homo sapiens_hsa041500.36805751
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36672275
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.35681137
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34445131
103Pathways in cancer_Homo sapiens_hsa052000.34014801
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33331458
105Fat digestion and absorption_Homo sapiens_hsa049750.32672970
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32580170
107Cardiac muscle contraction_Homo sapiens_hsa042600.32574542
108Biosynthesis of amino acids_Homo sapiens_hsa012300.31909813
109Primary immunodeficiency_Homo sapiens_hsa053400.31550814
110N-Glycan biosynthesis_Homo sapiens_hsa005100.30085448
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29247737
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29231279
113Retinol metabolism_Homo sapiens_hsa008300.28303577
114Arginine biosynthesis_Homo sapiens_hsa002200.27566656
115Notch signaling pathway_Homo sapiens_hsa043300.26248634
116Alzheimers disease_Homo sapiens_hsa050100.24418765
117Acute myeloid leukemia_Homo sapiens_hsa052210.24273040
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24064625
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23978414
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.23507348
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21910496
122Pyruvate metabolism_Homo sapiens_hsa006200.19790953
123Glycerolipid metabolism_Homo sapiens_hsa005610.17056843
124Oocyte meiosis_Homo sapiens_hsa041140.15856907
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14720123
126Serotonergic synapse_Homo sapiens_hsa047260.13877560
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13845725
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.13127837
129Tryptophan metabolism_Homo sapiens_hsa003800.13069381
130Regulation of autophagy_Homo sapiens_hsa041400.12228281
131Taste transduction_Homo sapiens_hsa047420.11791274
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.10751930
133Wnt signaling pathway_Homo sapiens_hsa043100.08903329
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.08476690
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.08434091
136VEGF signaling pathway_Homo sapiens_hsa043700.08233190
137Rap1 signaling pathway_Homo sapiens_hsa040150.08024291
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.06588129

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