TSC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1semaphorin-plexin signaling pathway (GO:0071526)4.65114548
2cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.36056848
3cell communication by electrical coupling (GO:0010644)4.25360964
4plasma membrane repair (GO:0001778)4.01825151
5mannose metabolic process (GO:0006013)3.93848252
6regulation of ARF GTPase activity (GO:0032312)3.88130363
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.74129064
8negative regulation of cytosolic calcium ion concentration (GO:0051481)3.71213054
9planar cell polarity pathway involved in neural tube closure (GO:0090179)3.65593332
10cytoskeletal anchoring at plasma membrane (GO:0007016)3.62921220
11regulation of short-term neuronal synaptic plasticity (GO:0048172)3.57887183
12synaptic vesicle maturation (GO:0016188)3.57058619
13layer formation in cerebral cortex (GO:0021819)3.52693128
14sodium ion export (GO:0071436)3.51636352
15cell communication involved in cardiac conduction (GO:0086065)3.47944166
16negative regulation of potassium ion transmembrane transport (GO:1901380)3.47547495
17response to pheromone (GO:0019236)3.45153345
18regulation of synapse structural plasticity (GO:0051823)3.39892939
19cerebellar Purkinje cell layer development (GO:0021680)3.38622616
20cardiac myofibril assembly (GO:0055003)3.37009804
21positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.35308074
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.33283585
23regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.32940497
24regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.31730030
25negative regulation of erythrocyte differentiation (GO:0045647)3.29522666
26sarcomere organization (GO:0045214)3.28770639
27cerebellar granule cell differentiation (GO:0021707)3.25924913
28establishment of nucleus localization (GO:0040023)3.24625222
29negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.23704419
30positive regulation of synapse maturation (GO:0090129)3.22741537
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22208371
32locomotory exploration behavior (GO:0035641)3.21456716
33endothelial cell chemotaxis (GO:0035767)3.16690044
34positive regulation of histone deacetylation (GO:0031065)3.16329436
35cardiac muscle contraction (GO:0060048)3.12237701
36cell-cell junction maintenance (GO:0045217)3.11839793
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.08963834
38regulation of synapse maturation (GO:0090128)3.06240488
39regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.05136752
40positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.01430117
41activation of protein kinase A activity (GO:0034199)3.01421845
42regulation of membrane repolarization (GO:0060306)2.98370417
43positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.96970420
44histone H4 deacetylation (GO:0070933)2.94930194
45vocalization behavior (GO:0071625)2.94095423
46apoptotic process involved in morphogenesis (GO:0060561)2.92968178
47myofibril assembly (GO:0030239)2.91968854
48* negative regulation of cell size (GO:0045792)2.91481591
49atrioventricular valve morphogenesis (GO:0003181)2.91317942
50cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.90543107
51positive regulation of protein kinase C signaling (GO:0090037)2.89770236
52dendritic spine morphogenesis (GO:0060997)2.88636412
53vascular endothelial growth factor signaling pathway (GO:0038084)2.87101804
54regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.84783067
55positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.84740504
56basement membrane organization (GO:0071711)2.84020903
57ventricular cardiac muscle cell action potential (GO:0086005)2.81678431
58negative regulation of fatty acid transport (GO:2000192)2.79341627
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.77808791
60neural tube development (GO:0021915)2.77781081
61intracellular estrogen receptor signaling pathway (GO:0030520)2.76334845
62cell migration in hindbrain (GO:0021535)2.75895734
63growth hormone secretion (GO:0030252)2.75129702
64potassium ion import (GO:0010107)2.74470325
65peptidyl-tyrosine autophosphorylation (GO:0038083)2.72643591
66carnitine shuttle (GO:0006853)2.72274484
67cellular potassium ion homeostasis (GO:0030007)2.70314748
68activation of Rac GTPase activity (GO:0032863)2.69963774
69regulation of NFAT protein import into nucleus (GO:0051532)2.69184687
70cell volume homeostasis (GO:0006884)2.68739858
71regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.67682669
72lung epithelium development (GO:0060428)2.66359606
73axonal fasciculation (GO:0007413)2.66305748
74cell-substrate junction assembly (GO:0007044)2.64914733
75positive regulation of CREB transcription factor activity (GO:0032793)2.63688307
76histone H3 deacetylation (GO:0070932)2.63317851
77neuronal ion channel clustering (GO:0045161)2.62534775
78membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.60688593
79negative regulation of myotube differentiation (GO:0010832)2.59541194
80regulation of glutamate receptor signaling pathway (GO:1900449)2.59052750
81positive regulation of blood vessel endothelial cell migration (GO:0043536)2.58702296
82retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.57276976
83adherens junction assembly (GO:0034333)2.56199577
84glutamate secretion (GO:0014047)2.55698880
85negative regulation of catenin import into nucleus (GO:0035414)2.53468991
86membrane depolarization during action potential (GO:0086010)2.52731245
87positive regulation of receptor recycling (GO:0001921)2.51069355
88establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.50593007
89mitochondrion transport along microtubule (GO:0047497)2.50593007
90vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.49479688
91dendrite morphogenesis (GO:0048813)2.48915206
92activation of JUN kinase activity (GO:0007257)2.48521633
93positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.48215547
94potassium ion homeostasis (GO:0055075)2.47798393
95synaptic vesicle exocytosis (GO:0016079)2.47482776
96regulation of histone H3-K27 methylation (GO:0061085)2.46303784
97membrane repolarization (GO:0086009)2.46279052
98neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.44362225
99regulation of glucose import in response to insulin stimulus (GO:2001273)2.44250280
100collecting duct development (GO:0072044)2.43755137
101regulation of p38MAPK cascade (GO:1900744)2.43559093
102regulation of synaptic vesicle exocytosis (GO:2000300)2.43324931
103protein targeting to plasma membrane (GO:0072661)2.42574776
104neuromuscular junction development (GO:0007528)2.42468338
105neuron recognition (GO:0008038)2.42325263
106Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.42196646
107polarized epithelial cell differentiation (GO:0030859)2.41017385
108protein heterotrimerization (GO:0070208)2.40469243
109histone H3-K9 demethylation (GO:0033169)2.40070019
110regulation of heart rate by cardiac conduction (GO:0086091)2.39973224
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.39094345
112establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.38672405
113membrane repolarization during action potential (GO:0086011)2.38641558
114cardiac muscle cell development (GO:0055013)2.37974834
115actomyosin structure organization (GO:0031032)2.37331084
116auditory behavior (GO:0031223)2.36819869
117neuron projection extension involved in neuron projection guidance (GO:1902284)2.35956364
118axon extension involved in axon guidance (GO:0048846)2.35956364
119cell-substrate adherens junction assembly (GO:0007045)2.35844905
120focal adhesion assembly (GO:0048041)2.35844905
121negative regulation of nucleotide catabolic process (GO:0030812)2.35679631
122regulation of ARF protein signal transduction (GO:0032012)2.34345927
123striated muscle contraction (GO:0006941)2.34067873
124neuromuscular process controlling balance (GO:0050885)2.34051955
125fatty acid transmembrane transport (GO:1902001)2.33916495
126regulation of calcium ion transmembrane transporter activity (GO:1901019)2.33193959
127regulation of calcium ion transmembrane transport (GO:1903169)2.33193959
128alanine transport (GO:0032328)2.33004164
129cardiac conduction (GO:0061337)2.32735016
130heterochromatin organization (GO:0070828)2.32639143
131cerebellar Purkinje cell differentiation (GO:0021702)2.31933596
132activation of MAPKKK activity (GO:0000185)2.30526749
133regulation of neuronal synaptic plasticity (GO:0048168)2.30344749
134positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.30163508
135camera-type eye morphogenesis (GO:0048593)2.30141483
136cell junction maintenance (GO:0034331)2.29998488
137cellular response to catecholamine stimulus (GO:0071870)2.29950664
138cellular response to monoamine stimulus (GO:0071868)2.29950664
139pre-miRNA processing (GO:0031054)2.29814067
140nucleus localization (GO:0051647)2.29696093
141protein retention in ER lumen (GO:0006621)2.29593710
142positive regulation of sodium ion transport (GO:0010765)2.29139997
143regulation of establishment of planar polarity (GO:0090175)2.27894917
144striatum development (GO:0021756)2.27241254
145establishment of mitochondrion localization (GO:0051654)2.26167378
146regulation of axon extension involved in axon guidance (GO:0048841)2.25461775
147regulation of fatty acid beta-oxidation (GO:0031998)2.24653752
148cardiac muscle cell action potential involved in contraction (GO:0086002)2.24253524
149regulation of histone deacetylation (GO:0031063)2.24179349
150convergent extension (GO:0060026)2.24091177
151cardiac muscle cell action potential (GO:0086001)2.24063401
152proline transport (GO:0015824)2.23908386
153regulation of hydrogen peroxide metabolic process (GO:0010310)2.23008900
154stress granule assembly (GO:0034063)2.22659158
155cardiac cell development (GO:0055006)2.22655796
156positive regulation of dendrite development (GO:1900006)2.22446545
157dopamine receptor signaling pathway (GO:0007212)2.21481230
158positive regulation of potassium ion transmembrane transport (GO:1901381)2.21468152
159* insulin-like growth factor receptor signaling pathway (GO:0048009)2.21307742
160apoptotic process involved in development (GO:1902742)2.19788854
161positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.19418488
162positive regulation of protein deacetylation (GO:0090312)2.18333914
163dermatan sulfate metabolic process (GO:0030205)2.17905034
164barbed-end actin filament capping (GO:0051016)2.17572984
165cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.17344219
166chondroitin sulfate catabolic process (GO:0030207)2.17276875
167regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.16156234
168G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.15836342
169negative regulation of Ras protein signal transduction (GO:0046580)2.14758887
170regulation of extracellular matrix disassembly (GO:0010715)2.13551708
171regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.13465791
172epithelial cell-cell adhesion (GO:0090136)2.13375759
173ear development (GO:0043583)2.12829270
174osteoblast development (GO:0002076)2.11598491
175regulation of endothelial cell chemotaxis (GO:2001026)2.10440232
176syncytium formation by plasma membrane fusion (GO:0000768)2.09860375
177eye morphogenesis (GO:0048592)2.09149146
178retrograde transport, endosome to Golgi (GO:0042147)2.09070920
179* negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.09057785
180lung morphogenesis (GO:0060425)2.08150955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.08817496
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.12398793
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.58638511
4ZFP281_18757296_ChIP-ChIP_E14_Mouse2.52305703
5DROSHA_22980978_ChIP-Seq_HELA_Human2.47551520
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.36865674
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.33758004
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22001592
9KDM2B_26808549_Chip-Seq_K562_Human2.20113706
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16322494
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16322494
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13500949
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12395269
14VDR_21846776_ChIP-Seq_THP-1_Human2.11257213
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.09681041
16* LXR_22292898_ChIP-Seq_THP-1_Human2.08666210
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00240862
18ZNF263_19887448_ChIP-Seq_K562_Human1.99814155
19* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.93120937
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91147066
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89541624
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.89404755
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86810205
24KDM2B_26808549_Chip-Seq_DND41_Human1.86771948
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86047592
26DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.85269813
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.85152406
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.84328043
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.82396906
30ZFP281_27345836_Chip-Seq_ESCs_Mouse1.81089767
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79221568
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72499200
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71807660
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70257474
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.69329032
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67286596
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.62675982
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.62338992
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59654398
40SA1_27219007_Chip-Seq_ERYTHROID_Human1.58049867
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57702464
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57170438
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56780600
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55993277
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.53976864
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48925484
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.47219879
48TBX20_22080862_ChIP-Seq_HEART_Mouse1.47219879
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.46965012
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46466711
51OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.46442625
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.46241882
53REST_21632747_ChIP-Seq_MESCs_Mouse1.45538837
54CREB1_26743006_Chip-Seq_LNCaP_Human1.45194587
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.45094865
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.44214245
57CTCF_27219007_Chip-Seq_Bcells_Human1.43376378
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42521156
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42035549
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41809154
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41155935
62TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.39703504
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39621684
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.37379007
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37195149
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37184432
67* SMC4_20622854_ChIP-Seq_HELA_Human1.37181025
68TP53_22127205_ChIP-Seq_IMR90_Human1.36631966
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.35138003
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35073838
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33833554
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33779320
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32765280
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30520895
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28125101
76ISL1_27105846_Chip-Seq_CPCs_Mouse1.27743184
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.27369901
78P68_20966046_ChIP-Seq_HELA_Human1.22732120
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21985026
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21785050
81CLOCK_20551151_ChIP-Seq_293T_Human1.21625833
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21504070
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21229875
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.20854451
85RACK7_27058665_Chip-Seq_MCF-7_Human1.20649757
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20475341
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.20242195
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19398259
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.19240651
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18935353
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18769550
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16494650
93BCOR_27268052_Chip-Seq_Bcells_Human1.16273168
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15854799
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.14640705
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.13769508
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13668930
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13581704
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.13569747
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12424227
101AR_19668381_ChIP-Seq_PC3_Human1.12212081
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12092733
103BCL6_27268052_Chip-Seq_Bcells_Human1.10122258
104MYC_22102868_ChIP-Seq_BL_Human1.10119968
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10113863
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09932840
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09101900
108ESR1_20079471_ChIP-ChIP_T-47D_Human1.08958225
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08890884
110* TP53_23651856_ChIP-Seq_MEFs_Mouse1.08345219
111TCF7_22412390_ChIP-Seq_EML_Mouse1.06664240
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06435107
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05724181
114PHF8_20622854_ChIP-Seq_HELA_Human1.03021981
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01835476
116* TP63_22573176_ChIP-Seq_HFKS_Human1.01509016
117KLF4_19829295_ChIP-Seq_ESCs_Human1.00459370
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00433817
119MAF_26560356_Chip-Seq_TH2_Human1.00264187
120FOXA2_19822575_ChIP-Seq_HepG2_Human1.00032290
121OCT4_19829295_ChIP-Seq_ESCs_Human0.98593480
122RARB_24833708_ChIP-Seq_LIVER_Mouse0.98131114
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97270025
124TRIM28_21343339_ChIP-Seq_HEK293_Human0.96684018
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.96640997
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95876441
127VDR_24763502_ChIP-Seq_THP-1_Human0.95711769
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95624474
129SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95390114
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94770291
131E2F1_20622854_ChIP-Seq_HELA_Human0.94051715
132* SA1_27219007_Chip-Seq_Bcells_Human0.93635536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.89211996
2MP0004859_abnormal_synaptic_plasticity3.78056247
3MP0000751_myopathy3.69039801
4MP0002249_abnormal_larynx_morphology3.07530225
5MP0001849_ear_inflammation2.89188230
6MP0005409_darkened_coat_color2.76326093
7MP0004084_abnormal_cardiac_muscle2.69529935
8MP0008438_abnormal_cutaneous_collagen2.66457860
9MP0003646_muscle_fatigue2.56458770
10MP0003172_abnormal_lysosome_physiology2.52132639
11MP0008260_abnormal_autophagy2.48700994
12MP0004145_abnormal_muscle_electrophysio2.42465483
13MP0003279_aneurysm2.38441381
14MP0004215_abnormal_myocardial_fiber2.37601884
15MP0003283_abnormal_digestive_organ2.36915200
16MP0001958_emphysema2.35270237
17MP0001348_abnormal_lacrimal_gland2.28331069
18MP0004036_abnormal_muscle_relaxation2.26889023
19MP0004233_abnormal_muscle_weight2.25280083
20MP0000678_abnormal_parathyroid_gland2.21933142
21MP0005058_abnormal_lysosome_morphology2.21416747
22MP0008961_abnormal_basal_metabolism2.14027294
23MP0004130_abnormal_muscle_cell2.10369002
24MP0000749_muscle_degeneration2.10019261
25MP0009780_abnormal_chondrocyte_physiolo2.04191244
26MP0004087_abnormal_muscle_fiber2.01712673
27* MP0003635_abnormal_synaptic_transmissio2.00355642
28MP0000566_synostosis1.99731767
29MP0005503_abnormal_tendon_morphology1.98992051
30MP0003137_abnormal_impulse_conducting1.93582812
31MP0002909_abnormal_adrenal_gland1.91573899
32MP0003705_abnormal_hypodermis_morpholog1.91352994
33MP0005330_cardiomyopathy1.84984892
34MP0002269_muscular_atrophy1.84298307
35MP0000747_muscle_weakness1.83207620
36MP0009384_cardiac_valve_regurgitation1.71135310
37MP0004858_abnormal_nervous_system1.64954080
38MP0004185_abnormal_adipocyte_glucose1.63865467
39MP0000759_abnormal_skeletal_muscle1.62967291
40MP0000013_abnormal_adipose_tissue1.60404190
41MP0000750_abnormal_muscle_regeneration1.59930430
42MP0000569_abnormal_digit_pigmentation1.53197668
43MP0003879_abnormal_hair_cell1.52477078
44MP0004085_abnormal_heartbeat1.49439499
45MP0004270_analgesia1.49226343
46MP0005257_abnormal_intraocular_pressure1.47774515
47MP0002106_abnormal_muscle_physiology1.46691332
48MP0005666_abnormal_adipose_tissue1.46633336
49* MP0002063_abnormal_learning/memory/cond1.46591381
50MP0010630_abnormal_cardiac_muscle1.41103052
51MP0005670_abnormal_white_adipose1.39455368
52MP0002234_abnormal_pharynx_morphology1.39185829
53MP0005620_abnormal_muscle_contractility1.39049548
54MP0005623_abnormal_meninges_morphology1.38693696
55MP0001502_abnormal_circadian_rhythm1.37144262
56MP0000767_abnormal_smooth_muscle1.36743477
57MP0005375_adipose_tissue_phenotype1.36275668
58MP0000003_abnormal_adipose_tissue1.36076249
59MP0009278_abnormal_bone_marrow1.35460023
60MP0004381_abnormal_hair_follicle1.33621328
61MP0002653_abnormal_ependyma_morphology1.32771101
62MP0002064_seizures1.32458976
63MP0003329_amyloid_beta_deposits1.30498238
64MP0005369_muscle_phenotype1.29885270
65MP0003942_abnormal_urinary_system1.29792699
66MP0000778_abnormal_nervous_system1.28370512
67MP0008775_abnormal_heart_ventricle1.28218132
68MP0005275_abnormal_skin_tensile1.27384836
69MP0002972_abnormal_cardiac_muscle1.26226930
70MP0002932_abnormal_joint_morphology1.23815640
71MP0006138_congestive_heart_failure1.22939409
72MP0002822_catalepsy1.21249148
73MP0003091_abnormal_cell_migration1.19885337
74MP0005076_abnormal_cell_differentiation1.19648703
75MP0002697_abnormal_eye_size1.19257882
76MP0005385_cardiovascular_system_phenoty1.16665027
77MP0001544_abnormal_cardiovascular_syste1.16665027
78MP0003119_abnormal_digestive_system1.15008834
79MP0010030_abnormal_orbit_morphology1.14244987
80MP0000681_abnormal_thyroid_gland1.10577301
81MP0000955_abnormal_spinal_cord1.10550591
82MP0009046_muscle_twitch1.10020938
83MP0009745_abnormal_behavioral_response1.09697179
84MP0004811_abnormal_neuron_physiology1.08930770
85MP0002184_abnormal_innervation1.05294921
86MP0004133_heterotaxia1.05153162
87MP0002116_abnormal_craniofacial_bone1.05003347
88MP0008569_lethality_at_weaning1.04740448
89MP0000534_abnormal_ureter_morphology1.04718680
90MP0000467_abnormal_esophagus_morphology1.00185207
91MP0000537_abnormal_urethra_morphology1.00152252
92MP0005508_abnormal_skeleton_morphology0.99947594
93MP0002108_abnormal_muscle_morphology0.98778388
94MP0003880_abnormal_central_pattern0.98602591
95MP0002089_abnormal_postnatal_growth/wei0.98130409
96MP0005451_abnormal_body_composition0.96582792
97MP0002933_joint_inflammation0.95675997
98MP0002572_abnormal_emotion/affect_behav0.95280321
99MP0003878_abnormal_ear_physiology0.94937499
100MP0005377_hearing/vestibular/ear_phenot0.94937499
101MP0004885_abnormal_endolymph0.94800434
102MP0000733_abnormal_muscle_development0.93654555
103MP0003115_abnormal_respiratory_system0.92675173
104MP0002882_abnormal_neuron_morphology0.92299540
105MP0002152_abnormal_brain_morphology0.91785624
106MP0002060_abnormal_skin_morphology0.90971073
107MP0004272_abnormal_basement_membrane0.90162321
108MP0001270_distended_abdomen0.89888955
109MP0003453_abnormal_keratinocyte_physiol0.89130825
110MP0001486_abnormal_startle_reflex0.88920013
111MP0000462_abnormal_digestive_system0.88271498
112MP0002272_abnormal_nervous_system0.87462308
113MP0002896_abnormal_bone_mineralization0.86492000
114MP0003690_abnormal_glial_cell0.84401375
115MP0001299_abnormal_eye_distance/0.84280952
116MP0003045_fibrosis0.83327279
117MP0004043_abnormal_pH_regulation0.82630314
118* MP0000266_abnormal_heart_morphology0.81672414
119MP0003948_abnormal_gas_homeostasis0.81560251
120MP0003122_maternal_imprinting0.80927090
121MP0005360_urolithiasis0.80739708
122MP0002090_abnormal_vision0.80044959
123MP0002127_abnormal_cardiovascular_syste0.78753347
124MP0005187_abnormal_penis_morphology0.78651194
125* MP0003861_abnormal_nervous_system0.78131099
126MP0002066_abnormal_motor_capabilities/c0.78078937
127MP0002114_abnormal_axial_skeleton0.77958686
128MP0002067_abnormal_sensory_capabilities0.77300885
129MP0005423_abnormal_somatic_nervous0.76989015
130MP0000428_abnormal_craniofacial_morphol0.75092729
131MP0004924_abnormal_behavior0.74231687
132MP0005386_behavior/neurological_phenoty0.74231687
133MP0005023_abnormal_wound_healing0.73262147
134MP0003385_abnormal_body_wall0.72815290
135MP0002733_abnormal_thermal_nociception0.72215880
136MP0010368_abnormal_lymphatic_system0.70982492
137MP0003566_abnormal_cell_adhesion0.70800786
138MP0004484_altered_response_of0.70716185
139MP0003634_abnormal_glial_cell0.70668253
140* MP0002925_abnormal_cardiovascular_devel0.70164223
141MP0001440_abnormal_grooming_behavior0.69898404
142MP0000579_abnormal_nail_morphology0.67258394
143MP0002078_abnormal_glucose_homeostasis0.66759529
144MP0002557_abnormal_social/conspecific_i0.65800119
145MP0003938_abnormal_ear_development0.65614641
146MP0000049_abnormal_middle_ear0.65071703
147MP0003935_abnormal_craniofacial_develop0.64704965
148MP0004510_myositis0.63184835
149MP0003633_abnormal_nervous_system0.62956576
150MP0000432_abnormal_head_morphology0.61504152
151MP0005595_abnormal_vascular_smooth0.61013081
152MP0002796_impaired_skin_barrier0.59985871
153* MP0001614_abnormal_blood_vessel0.59291109

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)5.02498612
2Sudden death (HP:0001699)4.27716323
3Broad face (HP:0000283)3.88866071
4Protrusio acetabuli (HP:0003179)3.55151218
5Exercise-induced myalgia (HP:0003738)3.49102928
6Thin bony cortex (HP:0002753)3.35812311
7Difficulty running (HP:0009046)3.32917207
8Cervical subluxation (HP:0003308)3.28971935
9Hyperacusis (HP:0010780)3.10973657
10Hyporeflexia of lower limbs (HP:0002600)3.10361130
11Nuclear cataract (HP:0100018)3.09521778
12Atrial fibrillation (HP:0005110)2.93525551
13Premature rupture of membranes (HP:0001788)2.86342898
14Ventricular fibrillation (HP:0001663)2.86156532
15Primary atrial arrhythmia (HP:0001692)2.85819907
16J-shaped sella turcica (HP:0002680)2.80945473
17Calf muscle hypertrophy (HP:0008981)2.79363233
18Stridor (HP:0010307)2.78965681
19Visual hallucinations (HP:0002367)2.74756061
20Insomnia (HP:0100785)2.74611844
21Muscle hypertrophy of the lower extremities (HP:0008968)2.74246376
22Bundle branch block (HP:0011710)2.73531939
23Prolonged QT interval (HP:0001657)2.73063205
24Myoglobinuria (HP:0002913)2.71250051
25Ventricular tachycardia (HP:0004756)2.70445269
26Supraventricular arrhythmia (HP:0005115)2.67812050
27Supraventricular tachycardia (HP:0004755)2.67726394
28Abnormality of the fingertips (HP:0001211)2.63490869
29Syncope (HP:0001279)2.59452930
30Abnormality of the calf musculature (HP:0001430)2.58595411
31Muscle fiber splitting (HP:0003555)2.58169368
32Cerebral aneurysm (HP:0004944)2.54820248
33Elfin facies (HP:0004428)2.54789739
34Increased variability in muscle fiber diameter (HP:0003557)2.54735312
35Focal seizures (HP:0007359)2.54203637
36Abnormality of the lower motor neuron (HP:0002366)2.53449815
37Disproportionate tall stature (HP:0001519)2.53359303
38Biconcave vertebral bodies (HP:0004586)2.53126264
39Macroorchidism (HP:0000053)2.52081087
40Exercise-induced muscle cramps (HP:0003710)2.50954707
41Ulnar bowing (HP:0003031)2.49206631
42Mitral regurgitation (HP:0001653)2.49069940
43Difficulty climbing stairs (HP:0003551)2.45755248
44Distal lower limb amyotrophy (HP:0008944)2.43650886
45Increased connective tissue (HP:0009025)2.43473798
46Upper limb amyotrophy (HP:0009129)2.42288338
47Distal upper limb amyotrophy (HP:0007149)2.42288338
48Limb-girdle muscle atrophy (HP:0003797)2.37303078
49Broad metatarsal (HP:0001783)2.36193073
50Zonular cataract (HP:0010920)2.35212137
51Shallow orbits (HP:0000586)2.34934300
52Renal duplication (HP:0000075)2.34426065
53Right ventricular cardiomyopathy (HP:0011663)2.33848760
54Fragile skin (HP:0001030)2.31523872
55Renovascular hypertension (HP:0100817)2.27672024
56Myokymia (HP:0002411)2.25275676
57Depression (HP:0000716)2.23056279
58Ankle clonus (HP:0011448)2.22264222
59Aortic aneurysm (HP:0004942)2.21977960
60Dysmetric saccades (HP:0000641)2.19996439
61Central scotoma (HP:0000603)2.19638906
62Focal motor seizures (HP:0011153)2.16951157
63Pointed chin (HP:0000307)2.15310313
64Overriding aorta (HP:0002623)2.14640591
65* Ventricular arrhythmia (HP:0004308)2.14597580
66Long toe (HP:0010511)2.14177796
67Abnormal social behavior (HP:0012433)2.14035957
68Impaired social interactions (HP:0000735)2.14035957
69Proximal amyotrophy (HP:0007126)2.13462257
70Atrophic scars (HP:0001075)2.12650480
71Abnormality of the aortic arch (HP:0012303)2.12559109
72EMG: myopathic abnormalities (HP:0003458)2.12421940
73Abnormality of the left ventricular outflow tract (HP:0011103)2.12090777
74Subaortic stenosis (HP:0001682)2.12090777
75Spinal canal stenosis (HP:0003416)2.11865506
76Abnormality of skeletal muscle fiber size (HP:0012084)2.11539642
77Rapidly progressive (HP:0003678)2.11122532
78Deformed sella turcica (HP:0002681)2.10999242
79Spinal rigidity (HP:0003306)2.09923859
80Annular pancreas (HP:0001734)2.09448060
81Ketoacidosis (HP:0001993)2.08565818
82Abnormal EKG (HP:0003115)2.08337097
83Supranuclear gaze palsy (HP:0000605)2.07809609
84Flat acetabular roof (HP:0003180)2.07782435
85Bell-shaped thorax (HP:0001591)2.07573519
86Scapular winging (HP:0003691)2.07252413
87Asymmetric septal hypertrophy (HP:0001670)2.06347213
88Hemiplegia (HP:0002301)2.06188887
89Metaphyseal cupping (HP:0003021)2.06003726
90Long palpebral fissure (HP:0000637)2.05876506
91Action tremor (HP:0002345)2.05603286
92Hand muscle atrophy (HP:0009130)2.05249190
93Flat cornea (HP:0007720)2.04969890
94Joint stiffness (HP:0001387)2.02969221
95Turricephaly (HP:0000262)2.00971545
96Aortic regurgitation (HP:0001659)2.00581796
97Thin ribs (HP:0000883)2.00103846
98* Lymphangioma (HP:0100764)1.99686110
99Bladder diverticulum (HP:0000015)1.99615970
100Myopathic facies (HP:0002058)1.97985279
101Myotonia (HP:0002486)1.97659692
102Hemorrhage of the eye (HP:0011885)1.95700980
103Atrioventricular block (HP:0001678)1.95088768
104Lower limb amyotrophy (HP:0007210)1.94451785
105Resting tremor (HP:0002322)1.94335120
106Athetosis (HP:0002305)1.93368819
107Poor eye contact (HP:0000817)1.92710123
108Type 1 muscle fiber predominance (HP:0003803)1.92427522
109* Neoplasm of the heart (HP:0100544)1.91268239
110Heart block (HP:0012722)1.91146117
111Premature skin wrinkling (HP:0100678)1.89340618
112Joint laxity (HP:0001388)1.89315873
113Dysdiadochokinesis (HP:0002075)1.88185993
114Mildly elevated creatine phosphokinase (HP:0008180)1.88024492
115Achilles tendon contracture (HP:0001771)1.87385923
116Dislocated radial head (HP:0003083)1.86930581
117Round ear (HP:0100830)1.86802716
118EMG: neuropathic changes (HP:0003445)1.85447548
119Vitreoretinal degeneration (HP:0000655)1.85122150
120Germ cell neoplasia (HP:0100728)1.84207051
121Abnormality of the radial head (HP:0003995)1.84135205
122Mitral valve prolapse (HP:0001634)1.83929094
123Lipoatrophy (HP:0100578)1.83207309
124* Aneurysm (HP:0002617)1.82730779
125Genu recurvatum (HP:0002816)1.82706476
126Urinary urgency (HP:0000012)1.82635137
127Sleep apnea (HP:0010535)1.82496621
128Wrist flexion contracture (HP:0001239)1.81757209
129Urinary bladder sphincter dysfunction (HP:0002839)1.81510693
130Large for gestational age (HP:0001520)1.81472471
131Hypoventilation (HP:0002791)1.79514176
132Blue sclerae (HP:0000592)1.79428494
133* Abnormality of the astrocytes (HP:0100707)1.78933768
134* Astrocytoma (HP:0009592)1.78933768
135Bowel diverticulosis (HP:0005222)1.78746736
136Frequent falls (HP:0002359)1.77562005
137Centrally nucleated skeletal muscle fibers (HP:0003687)1.77197840
138Wormian bones (HP:0002645)1.77179601
139Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76238218
140Abnormality of the distal phalanx of the thumb (HP:0009617)1.76157076
141Aortic dissection (HP:0002647)1.75637754
142Abnormal atrioventricular conduction (HP:0005150)1.75564527
143Spastic gait (HP:0002064)1.74752218
144Bronchomalacia (HP:0002780)1.74082597
145Abnormality of the Achilles tendon (HP:0005109)1.73042803
146Urinary glycosaminoglycan excretion (HP:0003541)1.72493186
147Mucopolysacchariduria (HP:0008155)1.72493186
148Back pain (HP:0003418)1.71081775
149Obsessive-compulsive behavior (HP:0000722)1.70660716
150Hypercortisolism (HP:0001578)1.69778146
151Short nail (HP:0001799)1.69661035
152Advanced eruption of teeth (HP:0006288)1.69018000
153Abnormality of the thoracic spine (HP:0100711)1.68984062
154Hyperinsulinemic hypoglycemia (HP:0000825)1.68446848
155Long eyelashes (HP:0000527)1.68388603
156Hypoplastic ischia (HP:0003175)1.68206178
157Dilated cardiomyopathy (HP:0001644)1.67504951
158Limb-girdle muscle weakness (HP:0003325)1.66906535
159Narrow palate (HP:0000189)1.66648893
160Distal lower limb muscle weakness (HP:0009053)1.66620170
161Neonatal short-limb short stature (HP:0008921)1.66163881
162Easy fatigability (HP:0003388)1.65546956
163Dilatation of the ascending aorta (HP:0005111)1.63782017
164Broad palm (HP:0001169)1.63591358
165Genetic anticipation (HP:0003743)1.63149205
166Abnormality of mucopolysaccharide metabolism (HP:0011020)1.61485248
167Abnormality of polysaccharide metabolism (HP:0011012)1.61485248
168Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61485248
169Wide anterior fontanel (HP:0000260)1.61362189
170Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59852203
171Vascular tortuosity (HP:0004948)1.58611402
172Bowed forearm bones (HP:0003956)1.58407166
173Bowing of the arm (HP:0006488)1.58407166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.37607190
2INSRR2.92500059
3TTN2.76876388
4PKN22.50746017
5SMG12.43124255
6PHKG12.38776033
7PHKG22.38776033
8PRKD32.35581422
9ICK2.25892590
10LMTK22.07258909
11PAK62.03283524
12MAP3K91.99399845
13RIPK11.92473515
14NTRK31.86116051
15MAP3K71.77837746
16PDGFRA1.77355384
17DAPK21.68675352
18PRPF4B1.67804691
19SIK11.65937985
20MAP3K41.65029509
21TYRO31.61961172
22EPHA41.61622953
23CDK121.61608261
24CAMK1G1.58951495
25STK381.58082528
26NEK11.57873886
27TNK21.55831644
28MST1R1.55825844
29KSR11.53184514
30EPHA21.53065724
31KSR21.51855049
32EPHB21.51671247
33MARK11.50988676
34PTK61.48398787
35ERN11.45040961
36PAK31.42563945
37DMPK1.31402401
38LATS11.29134985
39MINK11.28427672
40MAP3K61.27572204
41CAMK1D1.21890243
42SCYL21.17474972
43CDC42BPA1.16713273
44NTRK21.16584357
45EEF2K1.13509735
46MAP2K31.12619158
47PRKD21.11087186
48MTOR1.05438030
49MAP3K101.05341226
50EPHB11.05252595
51MARK21.05196323
52RET1.00062841
53FER0.99893361
54UHMK10.99758425
55* RPS6KA20.97745403
56MET0.96709688
57PTK20.96530554
58CAMKK10.96360031
59ALK0.95922449
60NTRK10.94838966
61LATS20.94342406
62MAPK150.94049251
63CAMK40.93988784
64PRKD10.92220043
65MAP3K130.91823301
66BRD40.89985636
67TAOK10.88232159
68MAP2K20.88027964
69EPHA30.85480255
70CDK50.83669223
71MAPK120.82430389
72HIPK20.82040115
73PRKCH0.81298093
74WNK10.80387343
75MAP2K40.78008499
76FGFR20.76746664
77SIK20.75883242
78MAP2K60.75402375
79PRKAA10.73829696
80CAMK10.73438031
81STK110.72264995
82ROCK10.71971072
83WNK30.71297295
84FGFR10.69706242
85BMX0.67470056
86DDR20.65496114
87ROCK20.63785687
88MAPK70.62202866
89ZAP700.61687227
90FGFR40.61323489
91DAPK30.60951355
92BCKDK0.60449229
93TESK10.60281601
94* RPS6KL10.59682574
95* RPS6KC10.59682574
96MAP3K110.58510989
97PTK2B0.58260477
98DYRK1B0.57527663
99PAK20.56375042
100PKN10.55331478
101WNK40.54682214
102MAPKAPK30.54084949
103OBSCN0.53530441
104MAP4K10.52283548
105PDK10.51861694
106PAK40.51642660
107MAPK80.51033432
108SGK10.51014154
109DAPK10.49668112
110FGFR30.49350987
111MAP3K10.47915632
112SGK4940.47702423
113SGK2230.47702423
114PNCK0.47677315
115BRSK10.47670444
116* RPS6KA30.47655008
117MAP3K30.46969978
118* RPS6KA60.46783962
119KDR0.45407526
120PRKCZ0.44125151
121PINK10.42949164
122MAPK100.42888560
123AKT20.42823191
124MAP3K20.41994474
125PDGFRB0.41976463
126CDK150.41762443
127CHUK0.41541284
128CDK180.40983717
129IRAK30.40268586
130CDK140.38692342
131NME10.38492830
132PDPK10.38317742
133PRKAA20.38141714
134SGK30.38122231
135MAPK110.38054681
136TBK10.36957449
137GRK60.34366062

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.17333459
2Dilated cardiomyopathy_Homo sapiens_hsa054142.11571131
3Nitrogen metabolism_Homo sapiens_hsa009102.04360673
4Other glycan degradation_Homo sapiens_hsa005111.97286260
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94358851
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89807240
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.88496252
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.82873835
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79826023
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.77039015
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75465259
12Insulin secretion_Homo sapiens_hsa049111.69651916
13Type II diabetes mellitus_Homo sapiens_hsa049301.69021219
14Circadian entrainment_Homo sapiens_hsa047131.64606439
15GABAergic synapse_Homo sapiens_hsa047271.55600384
16Cardiac muscle contraction_Homo sapiens_hsa042601.53545157
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47500745
18Acute myeloid leukemia_Homo sapiens_hsa052211.47408394
19Synaptic vesicle cycle_Homo sapiens_hsa047211.47331948
20Long-term potentiation_Homo sapiens_hsa047201.42661186
21Olfactory transduction_Homo sapiens_hsa047401.41682446
22Lysine degradation_Homo sapiens_hsa003101.39485681
23Oxytocin signaling pathway_Homo sapiens_hsa049211.38792639
24Glutamatergic synapse_Homo sapiens_hsa047241.36177800
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.33884965
26ECM-receptor interaction_Homo sapiens_hsa045121.29515298
27Gap junction_Homo sapiens_hsa045401.28536417
28Fatty acid degradation_Homo sapiens_hsa000711.28452653
29Cholinergic synapse_Homo sapiens_hsa047251.27408478
30Nicotine addiction_Homo sapiens_hsa050331.26997115
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25392887
32Morphine addiction_Homo sapiens_hsa050321.24346880
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23567892
34Renin secretion_Homo sapiens_hsa049241.22174190
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21939104
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21182957
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20658825
38Gastric acid secretion_Homo sapiens_hsa049711.20645717
39Dopaminergic synapse_Homo sapiens_hsa047281.20610778
40Salivary secretion_Homo sapiens_hsa049701.19559116
41* Choline metabolism in cancer_Homo sapiens_hsa052311.19128273
42Axon guidance_Homo sapiens_hsa043601.18131741
43* mTOR signaling pathway_Homo sapiens_hsa041501.15471636
44* Insulin signaling pathway_Homo sapiens_hsa049101.14213864
45Glucagon signaling pathway_Homo sapiens_hsa049221.13890812
46Fatty acid metabolism_Homo sapiens_hsa012121.13270287
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13217086
48GnRH signaling pathway_Homo sapiens_hsa049121.10294964
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09821680
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.09760242
51Glioma_Homo sapiens_hsa052141.08943217
52Estrogen signaling pathway_Homo sapiens_hsa049151.08051786
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06696843
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06533874
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05759061
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03954333
57Insulin resistance_Homo sapiens_hsa049311.03397993
58* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02666784
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02079865
60Amphetamine addiction_Homo sapiens_hsa050311.01418033
61Carbon metabolism_Homo sapiens_hsa012000.99149924
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99059357
63* AMPK signaling pathway_Homo sapiens_hsa041520.98425625
64Arginine biosynthesis_Homo sapiens_hsa002200.97321316
65Cocaine addiction_Homo sapiens_hsa050300.96529795
66Melanogenesis_Homo sapiens_hsa049160.96293155
67* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95939385
68cAMP signaling pathway_Homo sapiens_hsa040240.95507345
69Calcium signaling pathway_Homo sapiens_hsa040200.94845532
70Propanoate metabolism_Homo sapiens_hsa006400.94430725
71Prolactin signaling pathway_Homo sapiens_hsa049170.93706114
72Basal cell carcinoma_Homo sapiens_hsa052170.91685107
73Prion diseases_Homo sapiens_hsa050200.91543054
74Rap1 signaling pathway_Homo sapiens_hsa040150.90340057
75Butanoate metabolism_Homo sapiens_hsa006500.89512149
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.88361119
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87486912
78Amoebiasis_Homo sapiens_hsa051460.86839439
79Endometrial cancer_Homo sapiens_hsa052130.84519106
80Pancreatic cancer_Homo sapiens_hsa052120.84468291
81Notch signaling pathway_Homo sapiens_hsa043300.84319819
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.83217158
83Focal adhesion_Homo sapiens_hsa045100.82525313
84Dorso-ventral axis formation_Homo sapiens_hsa043200.81978439
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81879399
86ErbB signaling pathway_Homo sapiens_hsa040120.81204170
87VEGF signaling pathway_Homo sapiens_hsa043700.80656015
88B cell receptor signaling pathway_Homo sapiens_hsa046620.80211711
89ABC transporters_Homo sapiens_hsa020100.79773378
90* Phospholipase D signaling pathway_Homo sapiens_hsa040720.78570624
91Long-term depression_Homo sapiens_hsa047300.78013629
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77759567
93Proteoglycans in cancer_Homo sapiens_hsa052050.77745009
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77305225
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76898168
96Hedgehog signaling pathway_Homo sapiens_hsa043400.76707292
97Endocytosis_Homo sapiens_hsa041440.75943574
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75781795
99Fatty acid biosynthesis_Homo sapiens_hsa000610.75180176
100Fructose and mannose metabolism_Homo sapiens_hsa000510.74773459
101Prostate cancer_Homo sapiens_hsa052150.73577233
102Taste transduction_Homo sapiens_hsa047420.73535930
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.73342572
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.72264488
105Colorectal cancer_Homo sapiens_hsa052100.70807456
106MicroRNAs in cancer_Homo sapiens_hsa052060.70391575
107Renal cell carcinoma_Homo sapiens_hsa052110.70101705
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.69867342
109Bile secretion_Homo sapiens_hsa049760.69203666
110Non-small cell lung cancer_Homo sapiens_hsa052230.67944588
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67925878
112Hippo signaling pathway_Homo sapiens_hsa043900.67766478
113Thyroid cancer_Homo sapiens_hsa052160.67017390
114Tight junction_Homo sapiens_hsa045300.66152738
115PPAR signaling pathway_Homo sapiens_hsa033200.65527482
116Pancreatic secretion_Homo sapiens_hsa049720.64207456
117Adherens junction_Homo sapiens_hsa045200.63863401
118Small cell lung cancer_Homo sapiens_hsa052220.63060554
119Protein digestion and absorption_Homo sapiens_hsa049740.61647701
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61355070
121Chronic myeloid leukemia_Homo sapiens_hsa052200.61226263
122Ras signaling pathway_Homo sapiens_hsa040140.60845484
123Biosynthesis of amino acids_Homo sapiens_hsa012300.60352747
124Bladder cancer_Homo sapiens_hsa052190.60132472
125Hepatitis C_Homo sapiens_hsa051600.59240023
126Thyroid hormone synthesis_Homo sapiens_hsa049180.58640530
127Wnt signaling pathway_Homo sapiens_hsa043100.55007411
128MAPK signaling pathway_Homo sapiens_hsa040100.54985017
129Inositol phosphate metabolism_Homo sapiens_hsa005620.53662399
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53426475
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52859516

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