TSC22D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)4.08978804
2neuron cell-cell adhesion (GO:0007158)3.97810225
3presynaptic membrane assembly (GO:0097105)3.89413314
4metanephric mesenchyme development (GO:0072075)3.88096805
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83611386
6pyrimidine nucleobase catabolic process (GO:0006208)3.81544148
7gamma-aminobutyric acid transport (GO:0015812)3.76307151
8regulation of synaptic vesicle transport (GO:1902803)3.63383811
9protein localization to synapse (GO:0035418)3.63160596
10kidney mesenchyme development (GO:0072074)3.61471299
11neurotransmitter secretion (GO:0007269)3.59518283
12synaptic transmission, glutamatergic (GO:0035249)3.55763486
13presynaptic membrane organization (GO:0097090)3.54639682
14auditory behavior (GO:0031223)3.45065329
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.44627304
16layer formation in cerebral cortex (GO:0021819)3.44561562
17regulation of male gonad development (GO:2000018)3.41451454
18neurotransmitter-gated ion channel clustering (GO:0072578)3.35311219
19cellular potassium ion homeostasis (GO:0030007)3.34989952
20negative regulation of synaptic transmission, GABAergic (GO:0032229)3.34381665
21positive regulation of male gonad development (GO:2000020)3.33950496
22sodium ion export (GO:0071436)3.32527123
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.29994213
24synaptic vesicle endocytosis (GO:0048488)3.21707570
25nucleobase catabolic process (GO:0046113)3.21231675
26neuron-neuron synaptic transmission (GO:0007270)3.19512920
27mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.16469053
28regulation of secondary heart field cardioblast proliferation (GO:0003266)3.15429441
29regulation of cardioblast proliferation (GO:0003264)3.15429441
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12698737
31neuronal ion channel clustering (GO:0045161)3.09544976
32establishment of mitochondrion localization (GO:0051654)3.08966112
33positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05713297
34negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03257701
35synapse assembly (GO:0007416)2.96722877
36glutamate receptor signaling pathway (GO:0007215)2.95823525
37C4-dicarboxylate transport (GO:0015740)2.94996543
38synaptic vesicle docking involved in exocytosis (GO:0016081)2.94430831
39regulation of neurotransmitter levels (GO:0001505)2.93793924
40mesenchymal to epithelial transition (GO:0060231)2.92260559
41gonadal mesoderm development (GO:0007506)2.92246124
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90263713
43dendritic spine organization (GO:0097061)2.89445014
44regulation of axon extension involved in axon guidance (GO:0048841)2.89257821
45regulation of long-term neuronal synaptic plasticity (GO:0048169)2.87936440
46neurotransmitter transport (GO:0006836)2.84913519
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.79828755
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.78711657
49synaptic vesicle maturation (GO:0016188)2.78707695
50neurotransmitter uptake (GO:0001504)2.76872195
51regulation of neurotransmitter secretion (GO:0046928)2.74990058
52positive regulation of mitochondrial fission (GO:0090141)2.74229216
53regulation of short-term neuronal synaptic plasticity (GO:0048172)2.73636422
54negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.72398886
55acidic amino acid transport (GO:0015800)2.69526646
56regulation of voltage-gated calcium channel activity (GO:1901385)2.69398330
57response to auditory stimulus (GO:0010996)2.68906529
58lymph vessel development (GO:0001945)2.68647665
59membrane depolarization during action potential (GO:0086010)2.65850175
60mesenchyme morphogenesis (GO:0072132)2.64637579
61regulation of axon guidance (GO:1902667)2.64327826
62glycosphingolipid biosynthetic process (GO:0006688)2.63760207
63glomerulus development (GO:0032835)2.63664361
64glutamate secretion (GO:0014047)2.62625283
65regulation of synaptic transmission, glutamatergic (GO:0051966)2.61005567
66regulation of dendritic spine morphogenesis (GO:0061001)2.60332741
67positive regulation of synapse assembly (GO:0051965)2.59908421
68nephron epithelium morphogenesis (GO:0072088)2.59380532
69nephron tubule morphogenesis (GO:0072078)2.59380532
70regulation of neurotransmitter transport (GO:0051588)2.58678766
71negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.58307794
72gamma-aminobutyric acid signaling pathway (GO:0007214)2.58125544
73regulation of cell communication by electrical coupling (GO:0010649)2.58119346
74locomotory exploration behavior (GO:0035641)2.58087283
75cerebellar granule cell differentiation (GO:0021707)2.57275097
76long-term synaptic potentiation (GO:0060291)2.57137487
77axonal fasciculation (GO:0007413)2.56325230
78transmission of nerve impulse (GO:0019226)2.56196718
79negative regulation of chondrocyte differentiation (GO:0032331)2.55863152
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55823444
81neuron projection extension involved in neuron projection guidance (GO:1902284)2.55573318
82axon extension involved in axon guidance (GO:0048846)2.55573318
83mechanosensory behavior (GO:0007638)2.55017296
84synaptic vesicle transport (GO:0048489)2.53528579
85establishment of synaptic vesicle localization (GO:0097480)2.53528579
86regulation of synapse structural plasticity (GO:0051823)2.52232241
87positive regulation of hormone biosynthetic process (GO:0046886)2.52136968
88regulation of glutamate receptor signaling pathway (GO:1900449)2.51800212
89glial cell proliferation (GO:0014009)2.51414481
90regulation of excitatory postsynaptic membrane potential (GO:0060079)2.50968115
91embryonic foregut morphogenesis (GO:0048617)2.50740575
92endocardial cushion morphogenesis (GO:0003203)2.49431145
93sex determination (GO:0007530)2.49427774
94response to gravity (GO:0009629)2.49056365
95amino acid import (GO:0043090)2.48808881
96positive regulation of membrane potential (GO:0045838)2.48677146
97cellular sodium ion homeostasis (GO:0006883)2.48613393
98neuron recognition (GO:0008038)2.48485086
99G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48043691
100calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.47879232
101skeletal muscle organ development (GO:0060538)2.47555412
102cell communication involved in cardiac conduction (GO:0086065)2.46494217
103cochlea development (GO:0090102)2.43997553
104epithelial cell differentiation involved in kidney development (GO:0035850)2.43966092
105synapse organization (GO:0050808)2.43048902
106regulation of vesicle fusion (GO:0031338)2.43022116
107negative regulation of cation channel activity (GO:2001258)2.42108395
108renal tubule morphogenesis (GO:0061333)2.41764898
109establishment of vesicle localization (GO:0051650)2.41632300
110negative regulation of calcium ion transmembrane transport (GO:1903170)2.41150270
111negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.41150270
112positive regulation of axon extension (GO:0045773)2.40183345
113negative regulation of appetite (GO:0032099)2.39121565
114negative regulation of response to food (GO:0032096)2.39121565
115negative regulation of heart rate (GO:0010459)2.39052641
116L-glutamate transport (GO:0015813)2.38157302
117nephron tubule formation (GO:0072079)2.37425534
118regulation of postsynaptic membrane potential (GO:0060078)2.37066948
119behavioral response to cocaine (GO:0048148)2.36672688
120outer ear morphogenesis (GO:0042473)2.36232085
121glomerular basement membrane development (GO:0032836)2.35448401
122potassium ion homeostasis (GO:0055075)2.35003766
123membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.34449648
124metanephric epithelium development (GO:0072207)2.34435047
125chondrocyte proliferation (GO:0035988)2.33971318
126vocalization behavior (GO:0071625)2.31884971
127cell communication by electrical coupling (GO:0010644)2.31648408
128regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.31564464
129response to pheromone (GO:0019236)2.30041704
130activation of protein kinase A activity (GO:0034199)2.29587203
131postsynaptic membrane organization (GO:0001941)2.29168323
132regulation of synaptic vesicle exocytosis (GO:2000300)2.28928893
133innervation (GO:0060384)2.28628060
134regulation of heart morphogenesis (GO:2000826)2.28501696
135embryonic skeletal joint morphogenesis (GO:0060272)2.27862864
136regulation of female gonad development (GO:2000194)2.26968415
137positive regulation of mesonephros development (GO:0061213)2.26943023
138dendrite morphogenesis (GO:0048813)2.25868196
139negative regulation of axon extension involved in axon guidance (GO:0048843)2.25254638
140establishment of nucleus localization (GO:0040023)2.25050420
141regulation of mesenchymal cell apoptotic process (GO:2001053)2.24975336
142axon extension (GO:0048675)2.24035702
143peptidyl-tyrosine autophosphorylation (GO:0038083)2.23119683
144collecting duct development (GO:0072044)2.22534277
145diaphragm development (GO:0060539)2.22427454
146embryonic viscerocranium morphogenesis (GO:0048703)2.22425652
147regulation of mesonephros development (GO:0061217)2.21281030
148synaptic vesicle exocytosis (GO:0016079)2.21132028
149regulation of transforming growth factor beta2 production (GO:0032909)2.19326657
150dendritic spine morphogenesis (GO:0060997)2.18492535
151proximal/distal pattern formation (GO:0009954)2.18412094
152positive regulation of vesicle fusion (GO:0031340)2.18406847
153regulation of organ formation (GO:0003156)2.18007722
154COPI coating of Golgi vesicle (GO:0048205)2.17653068
155Golgi transport vesicle coating (GO:0048200)2.17653068
156regulation of neuronal synaptic plasticity (GO:0048168)2.15912883
157positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.15879869
158exploration behavior (GO:0035640)2.15563225
159limb bud formation (GO:0060174)2.15514470
160vascular endothelial growth factor signaling pathway (GO:0038084)2.14775341
161negative regulation of catenin import into nucleus (GO:0035414)2.14635774
162negative regulation of cartilage development (GO:0061037)2.14532025
163positive regulation of gastrulation (GO:2000543)2.13605581
164cell differentiation involved in metanephros development (GO:0072202)2.13490406
165heart valve formation (GO:0003188)2.13376758
166regulation of steroid hormone biosynthetic process (GO:0090030)2.12693552
167central nervous system projection neuron axonogenesis (GO:0021952)2.12064019
168neural crest cell development (GO:0014032)2.10315386
169branching involved in ureteric bud morphogenesis (GO:0001658)2.10298415
170cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.10050299
171facial nerve structural organization (GO:0021612)2.10010240
172membrane repolarization during action potential (GO:0086011)2.09333122
173positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.08451907
174embryonic heart tube development (GO:0035050)2.08275069
175exocrine pancreas development (GO:0031017)2.07764424
176mating behavior (GO:0007617)2.07748832
177gastrulation with mouth forming second (GO:0001702)2.07549569
178relaxation of cardiac muscle (GO:0055119)2.07417419
179regulation of glomerulus development (GO:0090192)2.07024082
180heart valve morphogenesis (GO:0003179)2.06070250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.40541273
2RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66281710
3EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66281710
4EED_16625203_ChIP-ChIP_MESCs_Mouse2.62484648
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61759723
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55917916
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.55599224
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49422108
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47696688
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47452124
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46156593
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.43727479
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41350629
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36438272
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34195900
16GBX2_23144817_ChIP-Seq_PC3_Human2.30584837
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26877200
18TAF15_26573619_Chip-Seq_HEK293_Human2.17882412
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16395212
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07886931
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.07449734
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.05830434
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.95591861
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93452037
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92594609
26* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89089880
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86455289
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.82345352
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.81246131
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74254092
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70934973
32P300_19829295_ChIP-Seq_ESCs_Human1.68107929
33* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66588363
34* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65576835
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.63413567
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.60865705
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.55817168
38RING1B_27294783_Chip-Seq_NPCs_Mouse1.53207981
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53060420
40DROSHA_22980978_ChIP-Seq_HELA_Human1.51607086
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51601800
42ZNF274_21170338_ChIP-Seq_K562_Hela1.50777396
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.49080306
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48394385
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47644595
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.45887804
47* EP300_21415370_ChIP-Seq_HL-1_Mouse1.42251004
48* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42233268
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41965116
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41859047
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41393365
52* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41030858
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38889302
54* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37517432
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36377218
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.35917325
57FUS_26573619_Chip-Seq_HEK293_Human1.34961561
58* RNF2_27304074_Chip-Seq_NSC_Mouse1.34208225
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34064537
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.33766594
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33538162
62AHR_22903824_ChIP-Seq_MCF-7_Human1.33283340
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33243760
64VDR_22108803_ChIP-Seq_LS180_Human1.32840883
65AR_21572438_ChIP-Seq_LNCaP_Human1.29824507
66ISL1_27105846_Chip-Seq_CPCs_Mouse1.29265974
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.28488318
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26426538
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26426538
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24659163
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24087485
72* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23405320
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.23232815
74KDM2B_26808549_Chip-Seq_K562_Human1.22920504
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.22796308
76* CLOCK_20551151_ChIP-Seq_293T_Human1.21180150
77* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20585107
78* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18795439
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.17335120
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.16654090
81REST_21632747_ChIP-Seq_MESCs_Mouse1.15052323
82* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14757502
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14488675
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14427026
85EWS_26573619_Chip-Seq_HEK293_Human1.13433102
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12788106
87* STAT3_23295773_ChIP-Seq_U87_Human1.12292022
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11172290
89SMAD4_21799915_ChIP-Seq_A2780_Human1.10247150
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10196659
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07763114
92TP53_18474530_ChIP-ChIP_U2OS_Human1.07334457
93* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06933724
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06407942
95OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05974650
96TCF4_23295773_ChIP-Seq_U87_Human1.05536536
97* TAL1_26923725_Chip-Seq_HPCs_Mouse1.04088618
98JUN_21703547_ChIP-Seq_K562_Human1.03601239
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03001955
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02629785
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02601157
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02113423
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.01695010
104* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99652510
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98613906
106RUNX2_22187159_ChIP-Seq_PCA_Human0.98311334
107NANOG_18555785_Chip-Seq_ESCs_Mouse0.96834314
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95591209
109IGF1R_20145208_ChIP-Seq_DFB_Human0.95531923
110* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94959931
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94461565
112* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94327670
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93980967
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93668371
115CBP_20019798_ChIP-Seq_JUKART_Human0.93668371
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93236166
117SOX2_21211035_ChIP-Seq_LN229_Gbm0.92599454
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.92401228
119* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91999675
120* AR_19668381_ChIP-Seq_PC3_Human0.91395175
121RXR_22108803_ChIP-Seq_LS180_Human0.91240737
122REST_18959480_ChIP-ChIP_MESCs_Mouse0.91183001
123* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90611045
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88735680
125TCF4_22108803_ChIP-Seq_LS180_Human0.88538941
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88364521
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87902762
128AR_25329375_ChIP-Seq_VCAP_Human0.87604622
129* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87437479
130STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87279202
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87215478
132ER_23166858_ChIP-Seq_MCF-7_Human0.86471709
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85672976
134* FLI1_21867929_ChIP-Seq_TH2_Mouse0.85605218
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85601306
136* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84305421
137BCAT_22108803_ChIP-Seq_LS180_Human0.84235603
138* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83788735
139CJUN_26792858_Chip-Seq_BT549_Human0.83759040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.10624241
2MP0010030_abnormal_orbit_morphology2.56951811
3MP0002064_seizures2.46220768
4MP0009046_muscle_twitch2.43104932
5MP0003122_maternal_imprinting2.42500726
6MP0002736_abnormal_nociception_after2.42231689
7MP0004859_abnormal_synaptic_plasticity2.33821405
8MP0001486_abnormal_startle_reflex2.33096961
9MP0002272_abnormal_nervous_system2.32478104
10MP0003283_abnormal_digestive_organ2.27789805
11MP0002572_abnormal_emotion/affect_behav2.23426567
12MP0000534_abnormal_ureter_morphology2.16871796
13MP0004272_abnormal_basement_membrane2.15633634
14MP0002735_abnormal_chemical_nociception2.15245241
15MP0003942_abnormal_urinary_system2.14021539
16MP0002822_catalepsy2.13591726
17MP0002102_abnormal_ear_morphology1.98345574
18MP0001188_hyperpigmentation1.90537539
19MP0000678_abnormal_parathyroid_gland1.85516404
20MP0002733_abnormal_thermal_nociception1.83046784
21MP0002909_abnormal_adrenal_gland1.82066088
22MP0001970_abnormal_pain_threshold1.79673909
23MP0003385_abnormal_body_wall1.78672774
24MP0009379_abnormal_foot_pigmentation1.78387804
25MP0001502_abnormal_circadian_rhythm1.76349909
26MP0000537_abnormal_urethra_morphology1.76309278
27MP0009250_abnormal_appendicular_skeleto1.74919521
28MP0005503_abnormal_tendon_morphology1.73791825
29MP0001501_abnormal_sleep_pattern1.73520614
30MP0002249_abnormal_larynx_morphology1.73343013
31MP0005623_abnormal_meninges_morphology1.72194610
32MP0000049_abnormal_middle_ear1.69793152
33MP0001529_abnormal_vocalization1.69001655
34MP0010368_abnormal_lymphatic_system1.63588721
35MP0005248_abnormal_Harderian_gland1.56011013
36MP0002067_abnormal_sensory_capabilities1.50385894
37MP0004885_abnormal_endolymph1.50277970
38MP0003329_amyloid_beta_deposits1.48512861
39MP0003635_abnormal_synaptic_transmissio1.45967869
40MP0001879_abnormal_lymphatic_vessel1.45950818
41MP0001905_abnormal_dopamine_level1.45659644
42MP0005167_abnormal_blood-brain_barrier1.44016833
43MP0003880_abnormal_central_pattern1.42396231
44MP0002234_abnormal_pharynx_morphology1.40680899
45MP0008569_lethality_at_weaning1.39758667
46MP0000778_abnormal_nervous_system1.39456107
47MP0003941_abnormal_skin_development1.39171362
48MP0004811_abnormal_neuron_physiology1.38983527
49MP0002877_abnormal_melanocyte_morpholog1.37176170
50MP0004858_abnormal_nervous_system1.34728532
51MP0003121_genomic_imprinting1.33695773
52MP0002896_abnormal_bone_mineralization1.33495400
53MP0000631_abnormal_neuroendocrine_gland1.32514476
54MP0005551_abnormal_eye_electrophysiolog1.31945911
55MP0004270_analgesia1.30764005
56MP0003123_paternal_imprinting1.30444702
57MP0005646_abnormal_pituitary_gland1.27844981
58MP0002233_abnormal_nose_morphology1.27320018
59MP0004215_abnormal_myocardial_fiber1.27312725
60MP0002282_abnormal_trachea_morphology1.27259412
61MP0005367_renal/urinary_system_phenotyp1.25729944
62MP0000516_abnormal_urinary_system1.25729944
63MP0002063_abnormal_learning/memory/cond1.25448824
64MP0002882_abnormal_neuron_morphology1.25435321
65MP0004924_abnormal_behavior1.25288112
66MP0005386_behavior/neurological_phenoty1.25288112
67MP0001984_abnormal_olfaction1.24687415
68MP0000013_abnormal_adipose_tissue1.24648038
69MP0002638_abnormal_pupillary_reflex1.24291931
70MP0002184_abnormal_innervation1.21472158
71MP0003119_abnormal_digestive_system1.21362105
72MP0001270_distended_abdomen1.20335675
73MP0003755_abnormal_palate_morphology1.20094067
74MP0001299_abnormal_eye_distance/1.19566535
75MP0005394_taste/olfaction_phenotype1.19364841
76MP0005499_abnormal_olfactory_system1.19364841
77MP0002653_abnormal_ependyma_morphology1.19121603
78MP0003115_abnormal_respiratory_system1.18213944
79MP0000163_abnormal_cartilage_morphology1.17273437
80MP0000762_abnormal_tongue_morphology1.17226137
81MP0003633_abnormal_nervous_system1.14751276
82MP0005645_abnormal_hypothalamus_physiol1.14726401
83MP0004233_abnormal_muscle_weight1.13910391
84MP0005187_abnormal_penis_morphology1.13690235
85MP0002066_abnormal_motor_capabilities/c1.13576238
86MP0008789_abnormal_olfactory_epithelium1.13425902
87MP0002116_abnormal_craniofacial_bone1.13231815
88MP0003935_abnormal_craniofacial_develop1.13147143
89MP0001346_abnormal_lacrimal_gland1.11648903
90MP0002938_white_spotting1.11465400
91MP0003787_abnormal_imprinting1.11077936
92MP0002734_abnormal_mechanical_nocicepti1.09864642
93MP0002932_abnormal_joint_morphology1.09330231
94MP0005508_abnormal_skeleton_morphology1.07747691
95MP0004142_abnormal_muscle_tone1.06176012
96MP0005084_abnormal_gallbladder_morpholo1.04917198
97MP0000751_myopathy1.04814402
98MP0005253_abnormal_eye_physiology1.04369846
99MP0008775_abnormal_heart_ventricle1.03967390
100MP0008961_abnormal_basal_metabolism1.02069669
101MP0003631_nervous_system_phenotype1.01500309
102MP0002557_abnormal_social/conspecific_i1.01368006
103MP0000566_synostosis0.97938029
104MP0001177_atelectasis0.97910724
105MP0001963_abnormal_hearing_physiology0.97509572
106MP0000955_abnormal_spinal_cord0.97174779
107MP0004484_altered_response_of0.96830128
108MP0001440_abnormal_grooming_behavior0.96179778
109MP0004134_abnormal_chest_morphology0.95629756
110MP0004084_abnormal_cardiac_muscle0.95476217
111MP0005377_hearing/vestibular/ear_phenot0.94937516
112MP0003878_abnormal_ear_physiology0.94937516
113MP0004147_increased_porphyrin_level0.94152025
114MP0009053_abnormal_anal_canal0.93795183
115MP0004133_heterotaxia0.93344294
116MP0009384_cardiac_valve_regurgitation0.93221957
117MP0002108_abnormal_muscle_morphology0.92853957
118MP0006276_abnormal_autonomic_nervous0.92639492
119MP0002152_abnormal_brain_morphology0.91409640
120MP0008872_abnormal_physiological_respon0.91228629
121MP0003937_abnormal_limbs/digits/tail_de0.91057619
122MP0002332_abnormal_exercise_endurance0.89506044
123MP0001958_emphysema0.87302386
124MP0002069_abnormal_eating/drinking_beha0.87018747
125MP0002115_abnormal_skeleton_extremities0.86812817
126MP0004742_abnormal_vestibular_system0.86777490
127MP0006138_congestive_heart_failure0.86636530
128MP0002229_neurodegeneration0.86529497
129MP0000026_abnormal_inner_ear0.85777502
130MP0009745_abnormal_behavioral_response0.85499165
131MP0000428_abnormal_craniofacial_morphol0.85452233
132MP0002752_abnormal_somatic_nervous0.83632733
133MP0003943_abnormal_hepatobiliary_system0.83142441
134MP0001485_abnormal_pinna_reflex0.82603095
135MP0001968_abnormal_touch/_nociception0.82395316
136MP0008995_early_reproductive_senescence0.81813438
137MP0002928_abnormal_bile_duct0.81568331
138MP0005423_abnormal_somatic_nervous0.81335408
139MP0001986_abnormal_taste_sensitivity0.81203729
140MP0003632_abnormal_nervous_system0.80396605
141MP0003861_abnormal_nervous_system0.80236725
142MP0002177_abnormal_outer_ear0.79700071
143MP0004085_abnormal_heartbeat0.79672117
144MP0000230_abnormal_systemic_arterial0.79584535
145MP0003879_abnormal_hair_cell0.79380503
146MP0002109_abnormal_limb_morphology0.79247739
147MP0002089_abnormal_postnatal_growth/wei0.79202704
148MP0002751_abnormal_autonomic_nervous0.79061534
149MP0006072_abnormal_retinal_apoptosis0.78196166
150MP0010386_abnormal_urinary_bladder0.78018888
151MP0003137_abnormal_impulse_conducting0.77659465
152MP0004043_abnormal_pH_regulation0.75777913
153MP0003634_abnormal_glial_cell0.75150154
154MP0003011_delayed_dark_adaptation0.72449642
155MP0005535_abnormal_body_temperature0.72194943
156MP0002090_abnormal_vision0.71666569

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.70843613
2Polyphagia (HP:0002591)3.93484384
3Febrile seizures (HP:0002373)3.72171668
4Action tremor (HP:0002345)3.68903677
5Atonic seizures (HP:0010819)3.66988377
6Abnormal eating behavior (HP:0100738)3.28693858
7Gait imbalance (HP:0002141)3.28326886
8Hemiparesis (HP:0001269)3.03718989
9Hepatoblastoma (HP:0002884)2.91573698
10Neonatal short-limb short stature (HP:0008921)2.90809452
11Medial flaring of the eyebrow (HP:0010747)2.81974743
12Split foot (HP:0001839)2.81259608
13Congenital primary aphakia (HP:0007707)2.79875401
14Spastic gait (HP:0002064)2.79842651
15Generalized tonic-clonic seizures (HP:0002069)2.78166177
16Epiphyseal dysplasia (HP:0002656)2.76595374
17Hyperventilation (HP:0002883)2.70233687
18Germ cell neoplasia (HP:0100728)2.68061423
19Absent speech (HP:0001344)2.67128253
20Progressive cerebellar ataxia (HP:0002073)2.66431349
21Abnormality of binocular vision (HP:0011514)2.65966236
22Diplopia (HP:0000651)2.65966236
23Nephrogenic diabetes insipidus (HP:0009806)2.60873442
24Failure to thrive in infancy (HP:0001531)2.56019566
25Urinary urgency (HP:0000012)2.51210161
26Lower limb muscle weakness (HP:0007340)2.47805123
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.47402471
28Epileptiform EEG discharges (HP:0011182)2.46814942
29Vitreoretinal degeneration (HP:0000655)2.45971016
30Drooling (HP:0002307)2.43200743
31Dysdiadochokinesis (HP:0002075)2.40186018
32EEG with generalized epileptiform discharges (HP:0011198)2.38446947
33Hypsarrhythmia (HP:0002521)2.38385523
34Aplasia involving bones of the extremities (HP:0009825)2.36326656
35Aplasia involving bones of the upper limbs (HP:0009823)2.36326656
36Aplasia of the phalanges of the hand (HP:0009802)2.36326656
37Bronchomalacia (HP:0002780)2.36245336
38Dialeptic seizures (HP:0011146)2.36031062
39Abnormal pancreas size (HP:0012094)2.35723021
40Abnormality of the corticospinal tract (HP:0002492)2.35276852
41Intention tremor (HP:0002080)2.34260253
42Impaired vibration sensation in the lower limbs (HP:0002166)2.32239596
43Specific learning disability (HP:0001328)2.31752719
44Hypoplastic ischia (HP:0003175)2.30306067
45Genital tract atresia (HP:0001827)2.28682981
46Delusions (HP:0000746)2.28380369
47Amyotrophic lateral sclerosis (HP:0007354)2.20488390
48Abnormality of dentin (HP:0010299)2.20243079
49Degeneration of the lateral corticospinal tracts (HP:0002314)2.18684688
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.18684688
51Spastic tetraplegia (HP:0002510)2.15099254
52Vaginal atresia (HP:0000148)2.14323757
53Broad-based gait (HP:0002136)2.12877601
54Excessive salivation (HP:0003781)2.12657216
55Absence seizures (HP:0002121)2.12065705
56Abnormality of the ischium (HP:0003174)2.11092808
57Clonus (HP:0002169)2.10196505
58Protrusio acetabuli (HP:0003179)2.10080933
59Enlarged penis (HP:0000040)2.06980840
60Mutism (HP:0002300)2.06748046
61Short tibia (HP:0005736)2.06734225
62Retinal dysplasia (HP:0007973)2.05452722
63Abnormal sex determination (HP:0012244)2.04824608
64Sex reversal (HP:0012245)2.04824608
65Truncal ataxia (HP:0002078)2.04524589
66Abnormality of the lower motor neuron (HP:0002366)2.02950679
67Supranuclear gaze palsy (HP:0000605)2.02699060
68Testicular neoplasm (HP:0010788)2.02697850
69Lymphangioma (HP:0100764)2.02120350
70Status epilepticus (HP:0002133)1.98963983
71Renal duplication (HP:0000075)1.96751980
72Hypoventilation (HP:0002791)1.96581832
73Myokymia (HP:0002411)1.94870270
74Aplasia/Hypoplasia of the tibia (HP:0005772)1.94623552
75Poor eye contact (HP:0000817)1.90852486
76Exercise-induced muscle cramps (HP:0003710)1.90264819
77Exostoses (HP:0100777)1.89986070
78Poor suck (HP:0002033)1.88667525
79Papillary thyroid carcinoma (HP:0002895)1.88478449
80Pancreatic fibrosis (HP:0100732)1.87954972
81Abnormality of the pubic bones (HP:0003172)1.86373397
82Urinary bladder sphincter dysfunction (HP:0002839)1.86239583
83Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85322088
84Upper limb muscle weakness (HP:0003484)1.83796463
85Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83398285
86Abnormality of the aortic arch (HP:0012303)1.82618838
87Morphological abnormality of the pyramidal tract (HP:0002062)1.82400295
88Sleep apnea (HP:0010535)1.81564843
89Dysmetria (HP:0001310)1.80503231
90Gaze-evoked nystagmus (HP:0000640)1.79051262
91Arterial tortuosity (HP:0005116)1.78890129
92Cerebral hypomyelination (HP:0006808)1.77655546
93Morphological abnormality of the middle ear (HP:0008609)1.77587731
94Mixed hearing impairment (HP:0000410)1.74673691
95Anxiety (HP:0000739)1.74640939
96Myotonia (HP:0002486)1.74639475
97Atrophic scars (HP:0001075)1.74611768
98Atrophy/Degeneration involving motor neurons (HP:0007373)1.73716432
99Asymmetry of the thorax (HP:0001555)1.73549377
100Decreased central vision (HP:0007663)1.73395309
101Neurofibrillary tangles (HP:0002185)1.72694539
102Occipital encephalocele (HP:0002085)1.72529844
103Ulnar claw (HP:0001178)1.72348889
104Bicornuate uterus (HP:0000813)1.72185735
105Broad foot (HP:0001769)1.71209087
106Megalencephaly (HP:0001355)1.70860381
107Optic nerve hypoplasia (HP:0000609)1.70268238
108Overgrowth (HP:0001548)1.70057314
109Agitation (HP:0000713)1.69327343
110Akinesia (HP:0002304)1.68529682
111Sprengel anomaly (HP:0000912)1.68250994
112Shallow orbits (HP:0000586)1.67437197
113Spinal rigidity (HP:0003306)1.66761174
114Inability to walk (HP:0002540)1.66692391
115Postural instability (HP:0002172)1.66540304
116Growth hormone excess (HP:0000845)1.66011485
117Cutaneous finger syndactyly (HP:0010554)1.65579952
118Broad metatarsal (HP:0001783)1.64714679
119Bundle branch block (HP:0011710)1.64611121
120Abnormal respiratory epithelium morphology (HP:0012253)1.64532984
121Abnormal respiratory motile cilium morphology (HP:0005938)1.64532984
122Hypoplasia of the corpus callosum (HP:0002079)1.64527695
123Poor coordination (HP:0002370)1.64259726
124Shoulder girdle muscle weakness (HP:0003547)1.63561609
125Focal dystonia (HP:0004373)1.62999600
126Lower limb asymmetry (HP:0100559)1.62997066
127Elfin facies (HP:0004428)1.62522714
128Impaired social interactions (HP:0000735)1.62381877
129Abnormal social behavior (HP:0012433)1.62381877
130Vascular tortuosity (HP:0004948)1.61492467
131Aplasia/Hypoplasia of the lens (HP:0008063)1.61359965
132Mild short stature (HP:0003502)1.60929471
133Renal hypoplasia (HP:0000089)1.60691782
134Increased circulating renin level (HP:0000848)1.60625338
135Flat acetabular roof (HP:0003180)1.60298274
136Shawl scrotum (HP:0000049)1.59232867
137Depression (HP:0000716)1.58012986
138Type II lissencephaly (HP:0007260)1.57373413
139Abnormality of the lacrimal duct (HP:0011481)1.53666427
140Gonadal dysgenesis (HP:0000133)1.53332182
141Focal seizures (HP:0007359)1.52528615
142Buphthalmos (HP:0000557)1.51202343
143Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.50372558
144Cutaneous syndactyly (HP:0012725)1.50215416
145Renal dysplasia (HP:0000110)1.49770780
146Bladder diverticulum (HP:0000015)1.47702794
147Accelerated skeletal maturation (HP:0005616)1.47022495
148True hermaphroditism (HP:0010459)1.46738996
149Epileptic encephalopathy (HP:0200134)1.46517913
150Tracheomalacia (HP:0002779)1.46435826
151Broad phalanx (HP:0006009)1.46400922
152Broad long bones (HP:0005622)1.46350936
153Annular pancreas (HP:0001734)1.46034658
154Advanced eruption of teeth (HP:0006288)1.45918680
155Metaphyseal cupping (HP:0003021)1.45700526
156Broad thumb (HP:0011304)1.45220501
157Abnormality of the nasolacrimal system (HP:0000614)1.44739746
158Congenital glaucoma (HP:0001087)1.44548231
159Broad finger (HP:0001500)1.44475361
160Limited hip movement (HP:0008800)1.44453586
161Osteoarthritis (HP:0002758)1.44321512
162Abnormality of the middle phalanges of the toes (HP:0010183)1.44215447
163Hydroureter (HP:0000072)1.43394480
164Limb dystonia (HP:0002451)1.42850113
165Abnormality of the phalanges of the 2nd finger (HP:0009541)1.42700201
166Irregular epiphyses (HP:0010582)1.41916759
167Hand muscle atrophy (HP:0009130)1.41865953
168Visual hallucinations (HP:0002367)1.41354385
169Omphalocele (HP:0001539)1.41321751
170Flat capital femoral epiphysis (HP:0003370)1.41002988
171Unilateral renal agenesis (HP:0000122)1.40199889
172Absent eyebrow (HP:0002223)1.39564007
173Down-sloping shoulders (HP:0200021)1.39055618
174Fetal akinesia sequence (HP:0001989)1.38896509
175Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.38768811
176Hypercalciuria (HP:0002150)1.38605971
177Genu varum (HP:0002970)1.38440616
178Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.38160842
179Short 4th metacarpal (HP:0010044)1.38160842
180Aortic aneurysm (HP:0004942)1.38002701
181Ankle clonus (HP:0011448)1.36790378
182Prolonged QT interval (HP:0001657)1.36644517
183Visceral angiomatosis (HP:0100761)1.36023623
184Torticollis (HP:0000473)1.36009756
185Broad ribs (HP:0000885)1.35888692
186Hip contracture (HP:0003273)1.35630919
187Fibular hypoplasia (HP:0003038)1.35448852
188Labial hypoplasia (HP:0000066)1.35335864

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.30348031
2MAP4K22.80846553
3MARK12.69010677
4ERBB32.54346017
5PRKD32.30325573
6NTRK32.29606847
7EPHB22.18563927
8DDR21.92034035
9EPHA41.89448975
10CSNK1G31.88393634
11CSNK1G21.87504112
12FER1.84901085
13CSNK1A1L1.83162572
14BCKDK1.80987282
15LATS21.78069934
16MINK11.77946042
17PIM21.73647730
18MAP3K91.71601788
19TRIM281.67728959
20PINK11.62116757
21KSR11.61828816
22WNK41.60508381
23PDGFRA1.59368223
24MAPK151.58097523
25MAP3K41.56284204
26PAK31.53013673
27CSNK1G11.51815071
28MAP3K21.50946858
29WNK31.50709168
30TRIB31.50488951
31DAPK21.45923875
32INSRR1.40081211
33GRK11.33141897
34GRK51.30601840
35TGFBR11.28300858
36LATS11.26027153
37LMTK21.23782791
38TYRO31.20769712
39BMPR1B1.19159546
40PTK2B1.17394834
41MAPK131.15009074
42MAP2K21.13422500
43NTRK11.12366908
44PTK21.10715961
45STK38L1.10126597
46CAMK2B1.09889207
47PHKG11.09583338
48PHKG21.09583338
49FRK1.09075603
50MAP3K121.08990990
51RIPK11.08923150
52MYLK1.08240618
53PAK61.08165242
54MAP2K11.06141274
55KSR21.05922412
56SIK31.05797800
57MAP2K70.98997257
58SGK4940.98850944
59SGK2230.98850944
60PASK0.98446545
61LIMK10.96697629
62CCNB10.96411171
63NTRK20.96332908
64PTK60.93264761
65PLK20.93080525
66STK380.91252647
67CAMKK10.89687538
68MAP3K30.89144431
69TESK10.88585690
70TAOK10.87808719
71CDK50.87165350
72CASK0.87067762
73CAMK2G0.85265193
74SGK20.84252888
75MAPKAPK30.84142419
76ARAF0.84118972
77OXSR10.82908547
78RPS6KA20.79737579
79EPHA20.79682429
80RET0.79377350
81CDK180.78536990
82PAK40.78021245
83TNIK0.74895153
84UHMK10.74008958
85AKT30.73885894
86DYRK1B0.73806850
87DYRK20.72910514
88PKN20.72428829
89CDK150.70316546
90PRKG20.70094852
91CAMK2D0.69756478
92ROCK10.69611645
93PKN10.68193247
94NEK60.68101849
95PRKCE0.67561267
96BCR0.67028689
97DYRK30.62472049
98DYRK1A0.61653971
99CDK11A0.58990090
100EPHA30.58253101
101FGFR10.57792557
102PRKCG0.55665207
103CAMKK20.55420772
104CDK80.54455040
105HIPK20.53883036
106ERBB20.53401036
107CDK190.52956616
108CAMK1G0.52661230
109STK390.52144424
110DAPK10.51794181
111MAP3K50.49658150
112BRD40.49243015
113CAMK10.48809313
114DMPK0.48512993
115MAPK70.47995264
116MARK20.47486646
117PDK20.47400340
118MAP2K40.47239531
119CDK140.47153866
120CDC42BPA0.46107460
121CAMK40.45885298
122FGFR20.45877417
123PRKACA0.45100052
124PRKCH0.44849251
125SGK30.44288162
126CAMK2A0.43812933
127PNCK0.43672841
128CDK90.43235049
129MAPKAPK50.43116701
130CSNK1A10.42668904
131WNK10.42139400
132BMPR20.41085898
133MAPK90.41025461
134PAK20.40966108
135OBSCN0.40814420
136TAOK20.40443190
137ADRBK20.36961513
138PRKD10.36792584
139CSNK1D0.35529990
140ADRBK10.35353109
141DAPK30.35208758
142BMX0.33932719
143PRKG10.32968761
144PRKCZ0.32203336
145PRKCA0.32198014
146MAP3K110.31441706

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10455696
2Aldosterone synthesis and secretion_Homo sapiens_hsa049251.99805973
3Olfactory transduction_Homo sapiens_hsa047401.99489235
4Circadian entrainment_Homo sapiens_hsa047131.92667275
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.91985240
6Insulin secretion_Homo sapiens_hsa049111.81507597
7Amphetamine addiction_Homo sapiens_hsa050311.78381828
8Axon guidance_Homo sapiens_hsa043601.75741909
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75131312
10Synaptic vesicle cycle_Homo sapiens_hsa047211.72059398
11Collecting duct acid secretion_Homo sapiens_hsa049661.64838730
12Dopaminergic synapse_Homo sapiens_hsa047281.63513414
13Gap junction_Homo sapiens_hsa045401.60786626
14ECM-receptor interaction_Homo sapiens_hsa045121.60346377
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.60206593
16Hippo signaling pathway_Homo sapiens_hsa043901.59474971
17Cocaine addiction_Homo sapiens_hsa050301.59444545
18Long-term potentiation_Homo sapiens_hsa047201.57554240
19Melanogenesis_Homo sapiens_hsa049161.56422814
20Cholinergic synapse_Homo sapiens_hsa047251.55847993
21Basal cell carcinoma_Homo sapiens_hsa052171.54927063
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54009647
23Hedgehog signaling pathway_Homo sapiens_hsa043401.53514469
24Ovarian steroidogenesis_Homo sapiens_hsa049131.53287254
25Phototransduction_Homo sapiens_hsa047441.50534615
26GABAergic synapse_Homo sapiens_hsa047271.48842431
27Nicotine addiction_Homo sapiens_hsa050331.47899796
28Gastric acid secretion_Homo sapiens_hsa049711.46460512
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46412641
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40759614
31Estrogen signaling pathway_Homo sapiens_hsa049151.38017028
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36212795
33Glutamatergic synapse_Homo sapiens_hsa047241.36055935
34Focal adhesion_Homo sapiens_hsa045101.34385784
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33419336
36Oxytocin signaling pathway_Homo sapiens_hsa049211.32296432
37Dilated cardiomyopathy_Homo sapiens_hsa054141.30706761
38Nitrogen metabolism_Homo sapiens_hsa009101.30561854
39Renin secretion_Homo sapiens_hsa049241.30492573
40GnRH signaling pathway_Homo sapiens_hsa049121.30077297
41Fatty acid elongation_Homo sapiens_hsa000621.28942328
42Adherens junction_Homo sapiens_hsa045201.28314269
43Morphine addiction_Homo sapiens_hsa050321.26563507
44Wnt signaling pathway_Homo sapiens_hsa043101.25537412
45TGF-beta signaling pathway_Homo sapiens_hsa043501.24992973
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23875210
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19717099
48Salivary secretion_Homo sapiens_hsa049701.19114248
49Long-term depression_Homo sapiens_hsa047301.18550082
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16587787
51Taste transduction_Homo sapiens_hsa047421.15644147
52Glioma_Homo sapiens_hsa052141.15545242
53Tight junction_Homo sapiens_hsa045301.14656256
54Endometrial cancer_Homo sapiens_hsa052131.12484738
55Arginine and proline metabolism_Homo sapiens_hsa003301.11789633
56Cardiac muscle contraction_Homo sapiens_hsa042601.11133819
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10298501
58Serotonergic synapse_Homo sapiens_hsa047261.09241947
59Protein digestion and absorption_Homo sapiens_hsa049741.08528776
60cAMP signaling pathway_Homo sapiens_hsa040241.07572020
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.06938019
62Vibrio cholerae infection_Homo sapiens_hsa051101.06787024
63Thyroid hormone synthesis_Homo sapiens_hsa049181.04338026
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02133059
65beta-Alanine metabolism_Homo sapiens_hsa004101.00151580
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98668555
67Proteoglycans in cancer_Homo sapiens_hsa052050.98449867
68Rap1 signaling pathway_Homo sapiens_hsa040150.98245536
69Colorectal cancer_Homo sapiens_hsa052100.97171662
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96916069
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95132026
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92857495
73Butanoate metabolism_Homo sapiens_hsa006500.92059167
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.90629789
75Oxidative phosphorylation_Homo sapiens_hsa001900.90169165
76Type II diabetes mellitus_Homo sapiens_hsa049300.88953622
77Calcium signaling pathway_Homo sapiens_hsa040200.87881766
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87321937
79Notch signaling pathway_Homo sapiens_hsa043300.86893212
80ErbB signaling pathway_Homo sapiens_hsa040120.86625495
81Circadian rhythm_Homo sapiens_hsa047100.86500003
82Bladder cancer_Homo sapiens_hsa052190.84681896
83Dorso-ventral axis formation_Homo sapiens_hsa043200.84534230
84Propanoate metabolism_Homo sapiens_hsa006400.83993713
85Thyroid cancer_Homo sapiens_hsa052160.83759364
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82551386
87Oocyte meiosis_Homo sapiens_hsa041140.82470079
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82084787
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80891672
90Glucagon signaling pathway_Homo sapiens_hsa049220.80852738
91Parkinsons disease_Homo sapiens_hsa050120.79088029
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78324853
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78172924
94Melanoma_Homo sapiens_hsa052180.77712638
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77424902
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76603924
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76531619
98Renal cell carcinoma_Homo sapiens_hsa052110.74298240
99Ras signaling pathway_Homo sapiens_hsa040140.74089827
100Regulation of autophagy_Homo sapiens_hsa041400.73266085
101Pancreatic secretion_Homo sapiens_hsa049720.73223743
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.70960703
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70382507
104Choline metabolism in cancer_Homo sapiens_hsa052310.70232502
105Alzheimers disease_Homo sapiens_hsa050100.69376107
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69266301
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.68932807
108Bile secretion_Homo sapiens_hsa049760.68746929
109VEGF signaling pathway_Homo sapiens_hsa043700.68452598
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67587461
111Pathways in cancer_Homo sapiens_hsa052000.66907690
112Prostate cancer_Homo sapiens_hsa052150.66613302
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.64916393
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.64593449
115Prolactin signaling pathway_Homo sapiens_hsa049170.64241303
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63228056
117Amoebiasis_Homo sapiens_hsa051460.63151526
118Histidine metabolism_Homo sapiens_hsa003400.62169955
119Chronic myeloid leukemia_Homo sapiens_hsa052200.62157133
120MAPK signaling pathway_Homo sapiens_hsa040100.61863704
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61452364
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60202130
123Alcoholism_Homo sapiens_hsa050340.59797743
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56258715
125MicroRNAs in cancer_Homo sapiens_hsa052060.55675439
126Peroxisome_Homo sapiens_hsa041460.55392759
127mTOR signaling pathway_Homo sapiens_hsa041500.54180012
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53951492
129Insulin signaling pathway_Homo sapiens_hsa049100.53708428
130N-Glycan biosynthesis_Homo sapiens_hsa005100.53705080
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53386942
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53358084
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52004665
134Fatty acid metabolism_Homo sapiens_hsa012120.50276378
135Ether lipid metabolism_Homo sapiens_hsa005650.48868725
136Arginine biosynthesis_Homo sapiens_hsa002200.48611562
137Steroid biosynthesis_Homo sapiens_hsa001000.47094405
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47037582
139Folate biosynthesis_Homo sapiens_hsa007900.45820465
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44117347
141Sulfur relay system_Homo sapiens_hsa041220.42126536
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41848833
143Mineral absorption_Homo sapiens_hsa049780.41240450
144AMPK signaling pathway_Homo sapiens_hsa041520.40642977
145Fatty acid biosynthesis_Homo sapiens_hsa000610.38087858
146Endocytosis_Homo sapiens_hsa041440.37198778
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36689334
148Linoleic acid metabolism_Homo sapiens_hsa005910.34617410
149Sulfur metabolism_Homo sapiens_hsa009200.34482828

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