TSC22D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of MHC class I biosynthetic process (GO:0045343)9.94821170
2negative regulation of type 2 immune response (GO:0002829)9.91166069
3sex differentiation (GO:0007548)8.92607828
4stress granule assembly (GO:0034063)7.89851849
5regulation of interleukin-13 production (GO:0032656)7.87713626
6cholesterol catabolic process (GO:0006707)7.54027803
7sterol catabolic process (GO:0016127)7.54027803
8cerebellar Purkinje cell differentiation (GO:0021702)6.97375387
9alternative mRNA splicing, via spliceosome (GO:0000380)6.93754264
10positive regulation of vasculogenesis (GO:2001214)6.74263514
11regulation of interleukin-5 production (GO:0032674)6.62872720
12negative regulation of receptor-mediated endocytosis (GO:0048261)6.36605094
13ADP metabolic process (GO:0046031)6.10899958
14kynurenine metabolic process (GO:0070189)6.03038119
15nucleoside diphosphate catabolic process (GO:0009134)5.96613875
16regulation of metalloenzyme activity (GO:0048552)5.74978051
17indole-containing compound catabolic process (GO:0042436)5.49164878
18indolalkylamine catabolic process (GO:0046218)5.49164878
19tryptophan catabolic process (GO:0006569)5.49164878
20regulation of vasculogenesis (GO:2001212)5.47034592
21centrosome duplication (GO:0051298)5.46441828
22lipid particle organization (GO:0034389)5.35038329
23negative regulation of endothelial cell apoptotic process (GO:2000352)5.08863255
24bile acid biosynthetic process (GO:0006699)4.68082478
25tryptophan metabolic process (GO:0006568)4.61241028
26regulation of action potential (GO:0098900)4.53372864
27regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.30241544
28acrosome assembly (GO:0001675)4.20666389
29chondrocyte proliferation (GO:0035988)4.18152277
30positive regulation of fatty acid beta-oxidation (GO:0032000)4.10427861
31negative regulation of endothelial cell proliferation (GO:0001937)4.09436988
32negative regulation of mast cell activation (GO:0033004)4.02975693
33positive regulation of heat generation (GO:0031652)3.95967664
34somite rostral/caudal axis specification (GO:0032525)3.95256611
35response to X-ray (GO:0010165)3.85488310
36protein autoprocessing (GO:0016540)3.83760569
37central nervous system projection neuron axonogenesis (GO:0021952)3.79942845
38negative regulation of T cell differentiation (GO:0045581)3.77415565
39synaptic transmission, cholinergic (GO:0007271)3.72763982
40ganglion development (GO:0061548)3.69376852
41phospholipid translocation (GO:0045332)3.69332045
42lipid translocation (GO:0034204)3.69332045
43regulation of triglyceride catabolic process (GO:0010896)3.69113377
44estrogen biosynthetic process (GO:0006703)3.66033124
45regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.60978137
46regulation of sequestering of triglyceride (GO:0010889)3.60715229
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.60332802
48neuronal action potential propagation (GO:0019227)3.59198615
49histone H3-K4 trimethylation (GO:0080182)3.56075181
50positive regulation of triglyceride biosynthetic process (GO:0010867)3.53593586
51regulation of type 2 immune response (GO:0002828)3.51229329
52central nervous system neuron axonogenesis (GO:0021955)3.49997820
53indolalkylamine metabolic process (GO:0006586)3.49172993
54regulation of heat generation (GO:0031650)3.46069952
55purine ribonucleoside diphosphate metabolic process (GO:0009179)3.45632213
56purine nucleoside diphosphate metabolic process (GO:0009135)3.45632213
57steroid catabolic process (GO:0006706)3.41464233
58regulation of receptor internalization (GO:0002090)3.37806276
59cell differentiation in hindbrain (GO:0021533)3.37142535
60cell adhesion mediated by integrin (GO:0033627)3.36158688
61positive regulation of mitotic sister chromatid separation (GO:1901970)3.34549033
62positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.34549033
63positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.34549033
64cytoplasmic mRNA processing body assembly (GO:0033962)3.34283664
65negative regulation of organ growth (GO:0046621)3.31906729
66response to lipoprotein particle (GO:0055094)3.29926033
67L-fucose metabolic process (GO:0042354)3.29874032
68L-fucose catabolic process (GO:0042355)3.29874032
69fucose catabolic process (GO:0019317)3.29874032
70seminiferous tubule development (GO:0072520)3.27804764
71regulation of establishment of cell polarity (GO:2000114)3.24084296
72regulation of phospholipid biosynthetic process (GO:0071071)3.23810341
73regulation of superoxide metabolic process (GO:0090322)3.23387580
74cellular biogenic amine catabolic process (GO:0042402)3.23341450
75amine catabolic process (GO:0009310)3.23341450
76positive regulation of fatty acid oxidation (GO:0046321)3.22921330
77NAD biosynthetic process (GO:0009435)3.22389891
78regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.21084639
79neural tube formation (GO:0001841)3.20285830
80fibroblast migration (GO:0010761)3.19265032
81negative regulation of endothelial cell migration (GO:0010596)3.17151808
82collagen fibril organization (GO:0030199)3.16820414
83regulation of RNA export from nucleus (GO:0046831)3.15191108
84aromatic amino acid family catabolic process (GO:0009074)3.14987868
85phosphatidylglycerol biosynthetic process (GO:0006655)3.07683152
86histone H3-K9 demethylation (GO:0033169)3.06828646
87lactate metabolic process (GO:0006089)3.06125601
88monoubiquitinated protein deubiquitination (GO:0035520)2.99703972
89face morphogenesis (GO:0060325)2.97627342
90negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.95536212
91negative regulation of translation, ncRNA-mediated (GO:0040033)2.95536212
92regulation of translation, ncRNA-mediated (GO:0045974)2.95536212
93regulation of endothelial cell apoptotic process (GO:2000351)2.95078346
94nuclear pore complex assembly (GO:0051292)2.92852094
95histone demethylation (GO:0016577)2.91786883
96histone lysine demethylation (GO:0070076)2.91456120
97L-methionine salvage (GO:0071267)2.89917499
98L-methionine biosynthetic process (GO:0071265)2.89917499
99amino acid salvage (GO:0043102)2.89917499
100craniofacial suture morphogenesis (GO:0097094)2.87928954
101cranial suture morphogenesis (GO:0060363)2.87717200
102termination of RNA polymerase III transcription (GO:0006386)2.86911288
103transcription elongation from RNA polymerase III promoter (GO:0006385)2.86911288
104skin morphogenesis (GO:0043589)2.83008625
105regulation of nucleobase-containing compound transport (GO:0032239)2.82565161
106negative regulation of reactive oxygen species metabolic process (GO:2000378)2.82314770
107platelet-derived growth factor receptor signaling pathway (GO:0048008)2.81873570
108regulation of response to reactive oxygen species (GO:1901031)2.81180781
109radial glial cell differentiation (GO:0060019)2.80218048
110mesodermal cell differentiation (GO:0048333)2.78938951
111regulation of triglyceride biosynthetic process (GO:0010866)2.78738650
112one-carbon compound transport (GO:0019755)2.78667817
113wound healing, spreading of epidermal cells (GO:0035313)2.77407512
114hippo signaling (GO:0035329)2.77377766
115regulation of gene silencing by RNA (GO:0060966)2.76575855
116regulation of posttranscriptional gene silencing (GO:0060147)2.76575855
117regulation of gene silencing by miRNA (GO:0060964)2.76575855
118cellular ketone body metabolic process (GO:0046950)2.76406303
119negative regulation of fatty acid transport (GO:2000192)2.75546175
120smooth muscle tissue development (GO:0048745)2.74655759
121negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.72164147
122positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.69549081
123mitotic sister chromatid cohesion (GO:0007064)2.69372315
124protein heterotrimerization (GO:0070208)2.68810226
125ovulation from ovarian follicle (GO:0001542)2.68786467
126auditory receptor cell stereocilium organization (GO:0060088)2.68743858
127pigmentation (GO:0043473)2.67937396
128histone H3-K36 demethylation (GO:0070544)2.67401308
129adult walking behavior (GO:0007628)2.67000537
130myoblast migration (GO:0051451)2.65181803
131metallo-sulfur cluster assembly (GO:0031163)2.64669819
132negative regulation of keratinocyte proliferation (GO:0010839)2.63466098
133sequestering of extracellular ligand from receptor (GO:0035581)2.60391568
134protein demethylation (GO:0006482)2.55444199
135protein dealkylation (GO:0008214)2.55444199
136mesenchymal-epithelial cell signaling (GO:0060638)2.54473788
137regulation of protein polyubiquitination (GO:1902914)2.53057369
138cartilage morphogenesis (GO:0060536)2.49792444
139cell migration involved in sprouting angiogenesis (GO:0002042)2.48484513
140regulation of tight junction assembly (GO:2000810)2.47375508
141pore complex assembly (GO:0046931)2.45959237
142tyrosine phosphorylation of STAT protein (GO:0007260)2.45485765
143maturation of 5.8S rRNA (GO:0000460)2.44631795
144regulation of establishment or maintenance of cell polarity (GO:0032878)2.44500173
145germ cell migration (GO:0008354)2.43936053
146embryonic process involved in female pregnancy (GO:0060136)2.43434034
147axon extension involved in axon guidance (GO:0048846)2.42038455
148neuron projection extension involved in neuron projection guidance (GO:1902284)2.42038455
149cellular response to gamma radiation (GO:0071480)2.41484570
150insulin-like growth factor receptor signaling pathway (GO:0048009)2.39663364
151cellular response to arsenic-containing substance (GO:0071243)2.38097997
152protein localization to cell surface (GO:0034394)2.37324657
153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.36929927
154regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.36929927
155protein localization to endosome (GO:0036010)2.36837685
156regulation of germinal center formation (GO:0002634)2.36287318
157morphogenesis of an epithelial sheet (GO:0002011)2.35987853
158endodermal cell differentiation (GO:0035987)2.35718748
159growth hormone receptor signaling pathway (GO:0060396)2.34273423
160nuclear pore organization (GO:0006999)2.33637966
161positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.31731017
162Notch signaling involved in heart development (GO:0061314)2.31269765
163positive regulation of p38MAPK cascade (GO:1900745)2.29038692
164embryonic cranial skeleton morphogenesis (GO:0048701)2.28885247
165regulation of interleukin-12 biosynthetic process (GO:0045075)2.27812202
166wound healing, spreading of cells (GO:0044319)2.26901990
167positive regulation of cartilage development (GO:0061036)2.24523865
168notochord development (GO:0030903)2.24383607
169definitive hemopoiesis (GO:0060216)2.22293571
170chondrocyte development (GO:0002063)2.21481629
171retina vasculature morphogenesis in camera-type eye (GO:0061299)2.21064491
172regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.17676134
173hepatocyte apoptotic process (GO:0097284)2.17154342
174regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.15751548
175positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.15751548
176neural crest cell development (GO:0014032)2.15530084
177substrate adhesion-dependent cell spreading (GO:0034446)2.14157450
178lymph vessel development (GO:0001945)2.12075317
179positive regulation of stem cell differentiation (GO:2000738)2.11117773
180mRNA transcription (GO:0009299)2.10945866
181megakaryocyte development (GO:0035855)2.10838994
182embryonic viscerocranium morphogenesis (GO:0048703)2.10609198
183positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.10539740
184pathway-restricted SMAD protein phosphorylation (GO:0060389)2.10061986
185SMAD protein complex assembly (GO:0007183)2.10052965
186regulation of keratinocyte differentiation (GO:0045616)2.09967655
187response to arsenic-containing substance (GO:0046685)2.09843207
188phagocytosis, engulfment (GO:0006911)2.09753142
189corticosteroid receptor signaling pathway (GO:0031958)2.09690157
190protein localization to kinetochore (GO:0034501)2.06832059
191response to fluid shear stress (GO:0034405)2.06653910
192positive regulation of epithelial to mesenchymal transition (GO:0010718)2.04850738
193pericardium development (GO:0060039)2.03315777
194positive regulation of mRNA catabolic process (GO:0061014)2.02962535
195glucocorticoid receptor signaling pathway (GO:0042921)2.01647925
196regulation of memory T cell differentiation (GO:0043380)12.2121993
197negative regulation of multicellular organism growth (GO:0040015)11.2327424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.48530244
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.55799173
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.10194360
4* CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.09109053
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.99062491
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.91865123
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.83707037
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.76494770
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.73518116
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.62727273
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.54995599
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.45457381
13TP53_16413492_ChIP-PET_HCT116_Human2.28621581
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.28486159
15ZNF274_21170338_ChIP-Seq_K562_Hela2.24508128
16* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.22973784
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.17914555
18* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.14591240
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06571170
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.06560830
21* CJUN_26792858_Chip-Seq_BT549_Human2.06517123
22* BCAT_22108803_ChIP-Seq_LS180_Human2.05809836
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.03437347
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.91834464
25* BRD4_25478319_ChIP-Seq_HGPS_Human1.86527006
26EZH2_22144423_ChIP-Seq_EOC_Human1.82483838
27TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.80836090
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74522261
29* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.73402577
30* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.73402577
31* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73374310
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.71533364
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68190262
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67307980
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.62089990
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.60586996
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60257447
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.58681368
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56240634
40* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52789804
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52692001
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.52111915
43CLOCK_20551151_ChIP-Seq_293T_Human1.51590706
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51493414
45OCT1_27270436_Chip-Seq_PROSTATE_Human1.51227303
46TP53_18474530_ChIP-ChIP_U2OS_Human1.50669599
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.49372158
48CDX2_22108803_ChIP-Seq_LS180_Human1.48672957
49* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46521979
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.45449997
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.44183594
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43505308
53FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.42875957
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42683581
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.42049658
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39988792
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.39978762
58TCF4_23295773_ChIP-Seq_U87_Human1.38097282
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37252218
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.35046280
61IRF1_19129219_ChIP-ChIP_H3396_Human1.34362001
62CBP_20019798_ChIP-Seq_JUKART_Human1.33941130
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33941130
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29754904
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29754904
66EWS_26573619_Chip-Seq_HEK293_Human1.29743143
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.29445717
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28765755
69TBL1_22424771_ChIP-Seq_293T_Human1.28131128
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27801870
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27438317
72SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26738832
73AHR_22903824_ChIP-Seq_MCF-7_Human1.25984988
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25681642
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24231011
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23119440
77DROSHA_22980978_ChIP-Seq_HELA_Human1.22431876
78FUS_26573619_Chip-Seq_HEK293_Human1.21409560
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18929922
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.17344123
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17156056
82* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16300622
83* KDM2B_26808549_Chip-Seq_REH_Human1.15837846
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15393801
85* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15213595
86* UBF1/2_26484160_Chip-Seq_HMECs_Human1.15014206
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14692206
88RXR_22108803_ChIP-Seq_LS180_Human1.14172515
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13948170
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.13716735
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13585016
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13478079
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13467734
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.13467734
95GBX2_23144817_ChIP-Seq_PC3_Human1.12777570
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12698646
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.12520161
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.12418363
99LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12369049
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12310043
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12171816
102* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12002972
103* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11774828
104* RUNX2_22187159_ChIP-Seq_PCA_Human1.11756355
105* TP63_23658742_ChIP-Seq_EP156T_Human1.11057487
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10459053
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.10393372
108* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10183967
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10150378
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10117742
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.09223643
112VDR_24787735_ChIP-Seq_THP-1_Human1.09070954
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07286489
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07084036
115TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.06642427
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06250017
117IGF1R_20145208_ChIP-Seq_DFB_Human1.06030970
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.05952722
119IRF8_21731497_ChIP-ChIP_J774_Mouse1.05743749
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04668767
121* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04495105
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04415218
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04198369
124* STAT3_23295773_ChIP-Seq_U87_Human1.03442961
125ER_23166858_ChIP-Seq_MCF-7_Human1.03066915
126CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02683441
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02572157
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02475880
129CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01647660
130* TCF4_22108803_ChIP-Seq_LS180_Human1.01596486
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01381894
132ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01095677
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.00791330
134REST_21632747_ChIP-Seq_MESCs_Mouse0.99117873
135* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99070145
136NCOR_22424771_ChIP-Seq_293T_Human0.98990803
137NFYA_21822215_ChIP-Seq_K562_Human0.98901143
138SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98699496
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98573651
140RUNX_20019798_ChIP-Seq_JUKART_Human0.98377256
141SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97661835
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97429962
143ISL1_27105846_Chip-Seq_CPCs_Mouse0.97048717
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96622228
145PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96559307
146FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96428242
147TAF15_26573619_Chip-Seq_HEK293_Human0.96275205
148P300_19829295_ChIP-Seq_ESCs_Human0.96201146
149* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96074366
150NFYB_21822215_ChIP-Seq_K562_Human0.95919406
151SMAD4_21799915_ChIP-Seq_A2780_Human0.95126588
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.94700742
153KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94099078
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.93732079
155VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93400946
156HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93288575
157FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92967916
158* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92949772
159AR_21572438_ChIP-Seq_LNCaP_Human0.91759211
160AR_25329375_ChIP-Seq_VCAP_Human0.91221598
161STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89076706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003252_abnormal_bile_duct7.02512904
2MP0003011_delayed_dark_adaptation5.96285499
3MP0002736_abnormal_nociception_after4.65683110
4MP0008438_abnormal_cutaneous_collagen3.96143149
5MP0001968_abnormal_touch/_nociception3.62138797
6MP0001986_abnormal_taste_sensitivity3.59213744
7MP0002877_abnormal_melanocyte_morpholog3.10607638
8MP0000371_diluted_coat_color3.02823588
9MP0005275_abnormal_skin_tensile2.99307446
10MP0005503_abnormal_tendon_morphology2.74626852
11MP0010352_gastrointestinal_tract_polyps2.59695319
12MP0003195_calcinosis2.49580800
13MP0005253_abnormal_eye_physiology2.38876228
14MP0001501_abnormal_sleep_pattern2.37096569
15MP0003279_aneurysm2.32509768
16MP0003091_abnormal_cell_migration2.27458047
17MP0005623_abnormal_meninges_morphology2.24047564
18MP0005646_abnormal_pituitary_gland2.24038809
19MP0009745_abnormal_behavioral_response2.23632594
20MP0005076_abnormal_cell_differentiation2.22911618
21MP0000733_abnormal_muscle_development2.16432101
22MP0002837_dystrophic_cardiac_calcinosis2.14144687
23MP0002102_abnormal_ear_morphology2.12803307
24MP0003705_abnormal_hypodermis_morpholog2.12475814
25MP0002060_abnormal_skin_morphology2.09653949
26MP0010368_abnormal_lymphatic_system2.01900077
27MP0002009_preneoplasia1.99741454
28MP0009384_cardiac_valve_regurgitation1.96459431
29MP0006072_abnormal_retinal_apoptosis1.95709108
30MP0000516_abnormal_urinary_system1.88127833
31MP0005367_renal/urinary_system_phenotyp1.88127833
32MP0000569_abnormal_digit_pigmentation1.87466279
33MP0005508_abnormal_skeleton_morphology1.84241455
34MP0003941_abnormal_skin_development1.82551753
35MP0000767_abnormal_smooth_muscle1.73680507
36MP0005647_abnormal_sex_gland1.68658106
37MP0010234_abnormal_vibrissa_follicle1.67646956
38MP0009250_abnormal_appendicular_skeleto1.66249553
39MP0010307_abnormal_tumor_latency1.65693667
40MP0005551_abnormal_eye_electrophysiolog1.64276054
41MP0008007_abnormal_cellular_replicative1.63534299
42MP0005171_absent_coat_pigmentation1.62627606
43MP0001299_abnormal_eye_distance/1.60738320
44MP0002282_abnormal_trachea_morphology1.58048135
45MP0003718_maternal_effect1.55995112
46MP0003755_abnormal_palate_morphology1.53696712
47MP0009046_muscle_twitch1.53273795
48MP0001958_emphysema1.52167556
49MP0003137_abnormal_impulse_conducting1.50424044
50MP0003950_abnormal_plasma_membrane1.46508699
51MP0003300_gastrointestinal_ulcer1.46090011
52MP0003828_pulmonary_edema1.45226997
53MP0002234_abnormal_pharynx_morphology1.44913287
54MP0004808_abnormal_hematopoietic_stem1.44737594
55MP0004885_abnormal_endolymph1.44676323
56MP0010386_abnormal_urinary_bladder1.43776322
57MP0004272_abnormal_basement_membrane1.43592337
58MP0003385_abnormal_body_wall1.41522495
59MP0002166_altered_tumor_susceptibility1.40795477
60MP0005174_abnormal_tail_pigmentation1.39385181
61MP0005257_abnormal_intraocular_pressure1.37871436
62MP0005334_abnormal_fat_pad1.37346907
63MP0003787_abnormal_imprinting1.34928574
64MP0001486_abnormal_startle_reflex1.33819078
65MP0003186_abnormal_redox_activity1.32552120
66MP0010678_abnormal_skin_adnexa1.32284737
67MP0003566_abnormal_cell_adhesion1.32117107
68MP0002108_abnormal_muscle_morphology1.30895104
69MP0005023_abnormal_wound_healing1.30604937
70MP0000432_abnormal_head_morphology1.30338279
71MP0006054_spinal_hemorrhage1.27820067
72MP0001177_atelectasis1.27111854
73MP0003172_abnormal_lysosome_physiology1.23373874
74MP0004130_abnormal_muscle_cell1.23357873
75MP0005083_abnormal_biliary_tract1.21967569
76MP0006035_abnormal_mitochondrial_morpho1.20905098
77MP0001915_intracranial_hemorrhage1.20639982
78MP0000427_abnormal_hair_cycle1.19942029
79MP0001851_eye_inflammation1.18852817
80MP0003453_abnormal_keratinocyte_physiol1.18072263
81MP0003119_abnormal_digestive_system1.18041669
82MP0002177_abnormal_outer_ear1.17691786
83MP0003937_abnormal_limbs/digits/tail_de1.17192262
84MP0002638_abnormal_pupillary_reflex1.16766102
85MP0002272_abnormal_nervous_system1.16599218
86MP0003646_muscle_fatigue1.16549000
87MP0002006_tumorigenesis1.16447355
88MP0009053_abnormal_anal_canal1.15279310
89MP0001666_abnormal_nutrient_absorption1.14637727
90MP0001879_abnormal_lymphatic_vessel1.14417645
91MP0002075_abnormal_coat/hair_pigmentati1.13709447
92MP0003935_abnormal_craniofacial_develop1.13555780
93MP0002138_abnormal_hepatobiliary_system1.13045011
94MP0002064_seizures1.12800701
95MP0004264_abnormal_extraembryonic_tissu1.09496993
96MP0005075_abnormal_melanosome_morpholog1.09103659
97MP0004924_abnormal_behavior1.06878674
98MP0005386_behavior/neurological_phenoty1.06878674
99MP0005197_abnormal_uvea_morphology1.05658514
100MP0004381_abnormal_hair_follicle1.05572157
101MP0008877_abnormal_DNA_methylation1.05437519
102MP0000428_abnormal_craniofacial_morphol1.05133513
103MP0005390_skeleton_phenotype1.05127591
104MP0002113_abnormal_skeleton_development1.04569120
105MP0001243_abnormal_dermal_layer1.04283292
106MP0004510_myositis1.03531211
107MP0010030_abnormal_orbit_morphology1.03242742
108MP0004043_abnormal_pH_regulation1.01884033
109MP0000566_synostosis0.99958213
110MP0000383_abnormal_hair_follicle0.99874418
111MP0000749_muscle_degeneration0.99488471
112MP0003115_abnormal_respiratory_system0.98938037
113MP0005248_abnormal_Harderian_gland0.98601532
114MP0002925_abnormal_cardiovascular_devel0.98564075
115MP0002233_abnormal_nose_morphology0.98483555
116MP0003045_fibrosis0.97040990
117MP0005410_abnormal_fertilization0.96007244
118MP0002396_abnormal_hematopoietic_system0.94341915
119MP0002116_abnormal_craniofacial_bone0.94337917
120MP0005388_respiratory_system_phenotype0.94310357
121MP0002133_abnormal_respiratory_system0.94310357
122MP0002693_abnormal_pancreas_physiology0.93959252
123MP0001340_abnormal_eyelid_morphology0.93635536
124MP0002932_abnormal_joint_morphology0.93234000
125MP0002998_abnormal_bone_remodeling0.93052979
126MP0002115_abnormal_skeleton_extremities0.90832126
127MP0008961_abnormal_basal_metabolism0.89289851
128MP0002109_abnormal_limb_morphology0.88275641
129MP0001346_abnormal_lacrimal_gland0.88025520
130MP0003938_abnormal_ear_development0.87771714
131MP0002254_reproductive_system_inflammat0.87281959
132MP0002128_abnormal_blood_circulation0.87139577
133MP0009840_abnormal_foam_cell0.86737186
134MP0000163_abnormal_cartilage_morphology0.86696327
135MP0001348_abnormal_lacrimal_gland0.86475102
136MP0003943_abnormal_hepatobiliary_system0.86335409
137MP0003936_abnormal_reproductive_system0.86306341
138MP0008057_abnormal_DNA_replication0.84821806
139MP0004147_increased_porphyrin_level0.84752968
140MP0001542_abnormal_bone_strength0.84437492
141MP0002896_abnormal_bone_mineralization0.84069482
142MP0003890_abnormal_embryonic-extraembry0.84045632
143MP0003448_altered_tumor_morphology0.83982719
144MP0001944_abnormal_pancreas_morphology0.83473750
145MP0000627_abnormal_mammary_gland0.83222162
146MP0004197_abnormal_fetal_growth/weight/0.83011450
147MP0001191_abnormal_skin_condition0.82694262
148MP0002697_abnormal_eye_size0.81192327
149MP0001324_abnormal_eye_pigmentation0.80892291
150MP0002928_abnormal_bile_duct0.79615363
151MP0001614_abnormal_blood_vessel0.79281320
152MP0004134_abnormal_chest_morphology0.78410005
153MP0001216_abnormal_epidermal_layer0.78206618
154MP0005395_other_phenotype0.77362958
155MP0002733_abnormal_thermal_nociception0.77329206
156MP0001784_abnormal_fluid_regulation0.76856806
157MP0000653_abnormal_sex_gland0.76744012
158MP0005391_vision/eye_phenotype0.76638113
159MP0000647_abnormal_sebaceous_gland0.75887263
160MP0006138_congestive_heart_failure0.75639619
161MP0001286_abnormal_eye_development0.75067367
162MP0002118_abnormal_lipid_homeostasis0.74552373
163MP0005636_abnormal_mineral_homeostasis0.71645281
164MP0005310_abnormal_salivary_gland0.71289239
165MP0002751_abnormal_autonomic_nervous0.70102744
166MP0001186_pigmentation_phenotype0.69441234
167MP0005084_abnormal_gallbladder_morpholo0.68399348
168MP0000631_abnormal_neuroendocrine_gland0.65705368
169MP0005620_abnormal_muscle_contractility0.65119357
170MP0002163_abnormal_gland_morphology0.64978252
171MP0002067_abnormal_sensory_capabilities0.64545635
172MP0002938_white_spotting0.63313756
173MP0004742_abnormal_vestibular_system0.61052735
174MP0002876_abnormal_thyroid_physiology0.60329086
175MP0005330_cardiomyopathy0.59964631
176MP0001764_abnormal_homeostasis0.59620647
177MP0008770_decreased_survivor_rate0.57474424
178MP0001119_abnormal_female_reproductive0.56939734
179MP0000026_abnormal_inner_ear0.55904975
180MP0000470_abnormal_stomach_morphology0.55300073
181MP0000372_irregular_coat_pigmentation0.54912455
182MP0002084_abnormal_developmental_patter0.54226678
183MP0005408_hypopigmentation0.52940614
184MP0009697_abnormal_copulation0.52628880
185MP0006036_abnormal_mitochondrial_physio0.52309993

Predicted human phenotypes

RankGene SetZ-score
1Progressive cerebellar ataxia (HP:0002073)8.48730839
2Gaze-evoked nystagmus (HP:0000640)5.92065553
3Absence seizures (HP:0002121)5.89163575
4Pendular nystagmus (HP:0012043)5.75997409
5Abnormality of the hepatic vasculature (HP:0006707)5.56448660
6Urinary bladder sphincter dysfunction (HP:0002839)5.43030499
7Slow saccadic eye movements (HP:0000514)5.39866201
8Postural tremor (HP:0002174)5.07736529
9Dysdiadochokinesis (HP:0002075)4.94329760
10Premature rupture of membranes (HP:0001788)4.87343557
11Postural instability (HP:0002172)4.77619312
12Dialeptic seizures (HP:0011146)4.62150261
13Impaired vibratory sensation (HP:0002495)4.46979558
14Focal seizures (HP:0007359)4.33447175
15Severe visual impairment (HP:0001141)4.29077287
16Asymmetry of the thorax (HP:0001555)4.28199441
17Hypochromic microcytic anemia (HP:0004840)4.23043724
18Syringomyelia (HP:0003396)4.22511907
19Spinal cord lesions (HP:0100561)4.22511907
20Limb ataxia (HP:0002070)4.12320855
21Impaired smooth pursuit (HP:0007772)3.90431368
22Protrusio acetabuli (HP:0003179)3.90081550
23Abnormality of the prostate (HP:0008775)3.79442711
24Shallow orbits (HP:0000586)3.69406596
25Impaired proprioception (HP:0010831)3.48905175
26Abnormality of macular pigmentation (HP:0008002)3.36419008
27Hyperventilation (HP:0002883)3.17515571
28Atrophic scars (HP:0001075)3.04438135
29Focal motor seizures (HP:0011153)2.94771127
30Aortic dissection (HP:0002647)2.93173474
31Postnatal microcephaly (HP:0005484)2.90064760
32Chorioretinal atrophy (HP:0000533)2.85633758
33Keratoconus (HP:0000563)2.82774356
34Increased corneal curvature (HP:0100692)2.82774356
35Areflexia of lower limbs (HP:0002522)2.82517868
36Atonic seizures (HP:0010819)2.78057873
37Abnormality of the nasal septum (HP:0000419)2.77410453
38Abnormality of ocular smooth pursuit (HP:0000617)2.69087210
39Vitreoretinal degeneration (HP:0000655)2.68150960
40Rib fusion (HP:0000902)2.65783966
41Hematochezia (HP:0002573)2.63915705
42Genu recurvatum (HP:0002816)2.59942924
43Soft skin (HP:0000977)2.58681459
44Cervical subluxation (HP:0003308)2.57832939
45Bilateral microphthalmos (HP:0007633)2.53450119
46Febrile seizures (HP:0002373)2.53091435
47Distal lower limb amyotrophy (HP:0008944)2.52491117
48Fragile skin (HP:0001030)2.49509448
49Follicular hyperkeratosis (HP:0007502)2.47710361
50Peritonitis (HP:0002586)2.47601238
51Osteolytic defects of the hand bones (HP:0009699)2.46210004
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.46210004
53Mitral valve prolapse (HP:0001634)2.42812877
54Abnormality of vision evoked potentials (HP:0000649)2.42733827
55Aortic aneurysm (HP:0004942)2.40029660
56Neoplasm of the adrenal cortex (HP:0100641)2.39307811
57Fair hair (HP:0002286)2.38391713
58Severe Myopia (HP:0011003)2.36082505
59Urethral obstruction (HP:0000796)2.33127313
60Biliary tract neoplasm (HP:0100574)2.31522831
61Short nail (HP:0001799)2.31250614
62Enlarged penis (HP:0000040)2.28079313
63Oculomotor apraxia (HP:0000657)2.23899969
64Wormian bones (HP:0002645)2.23453965
65Hypochromic anemia (HP:0001931)2.23390860
66Cerebral aneurysm (HP:0004944)2.22987755
67Abnormality of male internal genitalia (HP:0000022)2.22875489
68Vascular tortuosity (HP:0004948)2.21142189
69Absent frontal sinuses (HP:0002688)2.20736236
70Abnormality of saccadic eye movements (HP:0000570)2.19629534
71Mesomelia (HP:0003027)2.17375971
72Ankle contracture (HP:0006466)2.17161407
73Dilatation of the ascending aorta (HP:0005111)2.16310776
74Lower limb amyotrophy (HP:0007210)2.16201827
75Clumsiness (HP:0002312)2.14776601
76Proximal tubulopathy (HP:0000114)2.14615845
77Retinitis pigmentosa (HP:0000510)2.13488906
78Persistence of primary teeth (HP:0006335)2.11092741
79Pancreatic cysts (HP:0001737)2.11002867
80Increased connective tissue (HP:0009025)2.09884401
81Acute myeloid leukemia (HP:0004808)2.09316333
82Alopecia of scalp (HP:0002293)2.07381155
83Decreased muscle mass (HP:0003199)2.05805691
84Short 4th metacarpal (HP:0010044)2.05790209
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05790209
86Sparse lateral eyebrow (HP:0005338)2.01578874
87Dislocated radial head (HP:0003083)2.01434548
88Genetic anticipation (HP:0003743)11.4696725
89Action tremor (HP:0002345)10.1016951
90Dysmetric saccades (HP:0000641)10.0616333
91Hemiparesis (HP:0001269)1.99578929
92Wrist flexion contracture (HP:0001239)1.98685962
93Broad ribs (HP:0000885)1.97764403
94Arterial tortuosity (HP:0005116)1.97428588
95Prostate neoplasm (HP:0100787)1.97251753
96Spinal rigidity (HP:0003306)1.95953220
97Thick nail (HP:0001805)1.94428284
98Overgrowth (HP:0001548)1.94191663
99Bladder diverticulum (HP:0000015)1.94182926
100Increased density of long bones (HP:0006392)1.93312965
101Exostoses (HP:0100777)1.92360420
102Neonatal short-limb short stature (HP:0008921)1.92278316
103Aplasia/Hypoplasia of the fovea (HP:0008060)1.91320304
104Hypoplasia of the fovea (HP:0007750)1.91320304
105Anomalous pulmonary venous return (HP:0010772)1.90537450
106Aplasia/Hypoplasia of the macula (HP:0008059)1.90249697
107Hypoplasia of the maxilla (HP:0000327)1.90230893
108Abnormality of the frontal sinuses (HP:0002687)1.89917574
109Portal hypertension (HP:0001409)1.89519772
110Bradykinesia (HP:0002067)1.88938039
111Lip pit (HP:0100267)1.88851432
112Macroorchidism (HP:0000053)1.88726337
113Abnormality of the radial head (HP:0003995)1.87333882
114Protruding tongue (HP:0010808)1.87220307
115Abnormal delivery (HP:0001787)1.87192775
116Long eyelashes (HP:0000527)1.86914816
117Cutaneous melanoma (HP:0012056)1.86104411
118Spondylolisthesis (HP:0003302)1.85336523
119Elbow flexion contracture (HP:0002987)1.84562392
120Abnormality of the fingertips (HP:0001211)1.82959043
121Narrow palate (HP:0000189)1.82901786
122True hermaphroditism (HP:0010459)1.82100120
123Broad metatarsal (HP:0001783)1.82077139
124Capillary hemangiomas (HP:0005306)1.81818295
125Hypoplastic ischia (HP:0003175)1.80729324
126Microglossia (HP:0000171)1.80691821
127Congenital sensorineural hearing impairment (HP:0008527)1.80148843
128Generalized hypopigmentation of hair (HP:0011358)1.78706642
129Deviation of the hallux (HP:0010051)1.78635432
130Pancreatic fibrosis (HP:0100732)1.78339416
131Mildly elevated creatine phosphokinase (HP:0008180)1.75549302
132Tinnitus (HP:0000360)1.75064070
133Abnormality of the neuromuscular junction (HP:0003398)1.74706260
134Fatigable weakness (HP:0003473)1.74706260
135Hypophosphatemic rickets (HP:0004912)1.73781758
136Myocardial infarction (HP:0001658)1.73515814
137Bell-shaped thorax (HP:0001591)1.73311956
138Aplasia/Hypoplasia affecting the retina (HP:0008061)1.73241963
139Camptodactyly of toe (HP:0001836)1.72655842
140Type 1 muscle fiber predominance (HP:0003803)1.72582000
141Hypoproteinemia (HP:0003075)1.72179939
142Hallux valgus (HP:0001822)1.72069852
143Decreased central vision (HP:0007663)1.71547840
144Congenital stationary night blindness (HP:0007642)1.71434090
145Absent speech (HP:0001344)1.71246457
146Joint laxity (HP:0001388)1.71234942
147Aqueductal stenosis (HP:0002410)1.69876899
148Abnormality of the pulmonary veins (HP:0011718)1.69757917
149Bowel diverticulosis (HP:0005222)1.69025217
150Abolished electroretinogram (ERG) (HP:0000550)1.68859431
151Cystic hygroma (HP:0000476)1.68678204
152Blue sclerae (HP:0000592)1.68279239
153Abnormality of the humeroradial joint (HP:0100744)1.67648348
154Tubular atrophy (HP:0000092)1.67111669
155Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66770028
156Abnormal biliary tract morphology (HP:0012440)1.66457501
157Buphthalmos (HP:0000557)1.66111766
158Abnormality of the ischium (HP:0003174)1.65960397
159Hip contracture (HP:0003273)1.64419203
160Natal tooth (HP:0000695)1.63810031
161Abnormality of dentin (HP:0010299)1.63796387
162Macular degeneration (HP:0000608)1.62475297
163Knee flexion contracture (HP:0006380)1.62054193
164Deep philtrum (HP:0002002)1.61704827
165Subacute progressive viral hepatitis (HP:0006572)1.60928087
166Papillary thyroid carcinoma (HP:0002895)1.59603311
167Volvulus (HP:0002580)1.59547041
168Hyperthyroidism (HP:0000836)1.59354178
169Hypoplastic iliac wings (HP:0002866)1.57744455
170Craniofacial hyperostosis (HP:0004493)1.57146257
171Chromosomal breakage induced by crosslinking agents (HP:0003221)1.56878878
172Fibular aplasia (HP:0002990)1.56717973
173Advanced eruption of teeth (HP:0006288)1.54467371
174Disproportionate short-trunk short stature (HP:0003521)1.54461764
175Muscle fiber splitting (HP:0003555)1.54129140
176Chromsome breakage (HP:0040012)1.53839280
177Increased number of teeth (HP:0011069)1.53450456
178Abnormal respiratory motile cilium physiology (HP:0012261)1.53278275
179Horizontal nystagmus (HP:0000666)1.52854221
180Incomplete penetrance (HP:0003829)1.52806378
181Thyroid carcinoma (HP:0002890)1.52698442
182Dysmetria (HP:0001310)1.51008705
183Nephronophthisis (HP:0000090)1.50085057
184Broad-based gait (HP:0002136)1.50042794
185Macroglossia (HP:0000158)1.49294094
186Gingival bleeding (HP:0000225)1.49159021
187Dynein arm defect of respiratory motile cilia (HP:0012255)1.47383850
188Absent/shortened dynein arms (HP:0200106)1.47383850
189Abnormality of the fovea (HP:0000493)1.46203588
190Fasciculations (HP:0002380)1.46165529
191Hemiplegia (HP:0002301)1.45862211
192Blue irides (HP:0000635)1.43514958
193Loss of speech (HP:0002371)1.43303974
194Attenuation of retinal blood vessels (HP:0007843)1.42699959
195Inability to walk (HP:0002540)1.40593068
196Concave nail (HP:0001598)1.40534266
197Exotropia (HP:0000577)1.39283126
198Scrotal hypoplasia (HP:0000046)1.39149397
199Hypobetalipoproteinemia (HP:0003563)1.38583572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR16.18099238
2FRK3.82075110
3MKNK13.34523605
4MKNK23.31566301
5LATS13.08090014
6MUSK3.03339674
7ERBB32.72416604
8GRK12.63160695
9MAP3K72.39633049
10LATS22.21474517
11ACVR1B2.19354969
12TNK22.11817564
13FGFR32.08575681
14FGFR22.08223185
15TRPM72.02805525
16MAP3K142.02260385
17CDK1910.4201465
18BCR1.80292354
19STK31.80024361
20CDK121.74827925
21DDR21.72160839
22CHUK1.68175329
23BRD41.66911953
24EPHB11.66688195
25EPHA31.66266971
26ERBB41.62244563
27PDGFRA1.55829882
28PINK11.55322075
29DMPK1.55253220
30TGFBR21.50088175
31TXK1.40150629
32ADRBK21.35307370
33ZAK1.31758593
34NLK1.30905128
35STK38L1.30741708
36SGK21.30640361
37RPS6KA41.30416741
38TTN1.29374312
39BRSK21.24513304
40BMPR21.14449577
41CDK91.14212169
42PDGFRB1.13972211
43RIPK11.13491206
44CDK31.10379801
45SGK31.10298537
46ALK1.09282348
47RPS6KB21.08800027
48NEK91.07840895
49IKBKB1.05201787
50BMX1.04727151
51NUAK11.01143569
52STK101.00193122
53PAK20.99845857
54CDK80.98190831
55TGFBR10.96382190
56PIM10.96369098
57MELK0.94354564
58STK380.92672861
59EIF2AK20.91693721
60MARK30.91073549
61PTK20.89903795
62CASK0.89587298
63MAP3K60.88192847
64CDK60.87672506
65WNK30.84679504
66DYRK1B0.84665982
67PTK60.83835957
68PRKAA20.81497449
69MAPKAPK50.79740158
70JAK10.79708771
71JAK30.77542411
72EPHA20.77250139
73TAOK30.76934057
74MOS0.75158679
75RPS6KA50.74582820
76PLK30.73972226
77TAF10.73465463
78MAP3K30.72740121
79CAMK1D0.71071433
80IRAK30.70926961
81GSK3A0.67951873
82WEE10.66884726
83PAK30.66591251
84MTOR0.65580478
85PIK3CA0.60417054
86WNK40.60390941
87MAP3K50.58940515
88ABL10.58419353
89SGK2230.57956252
90SGK4940.57956252
91CAMK1G0.57671211
92CLK10.55262897
93NEK60.54418942
94MAPK70.54228586
95TIE10.54169479
96DYRK1A0.53865149
97TNIK0.52889783
98PRPF4B0.52832967
99INSRR0.52367279
100MAPK130.50919330
101ADRBK10.50315557
102IKBKE0.50155572
103SIK10.49811287
104PLK20.49377648
105FER0.49370587
106EPHB20.49054020
107STK240.48317632
108CSNK1G20.47713448
109STK40.47103362
110MAPKAPK20.47040596
111MST40.46298012
112FGFR10.46010687
113PIM20.44909621
114DYRK30.44617794
115AKT30.44525768
116PTK2B0.44090022
117SGK10.43547961
118MAP2K10.43199569
119CSNK1A1L0.42528745
120TRIM280.42448193
121MAPK80.41018089
122CSNK1G10.40865137
123BMPR1B0.40236091
124MAPK10.39687905
125MAP3K40.39512582
126MAP4K20.39165003
127HIPK20.38329968
128STK390.38250059
129DYRK20.38032906
130STK110.37955454
131PKN10.37674986
132CSNK1G30.36715171
133MAPK150.36415241
134FGFR40.36334773
135CHEK20.36236376
136CHEK10.33520195
137ERBB20.30905427
138PRKCG0.29883350
139JAK20.29849434
140PRKCE0.29698413
141PDK10.29692682
142PRKG10.28120546
143CDK50.25037328
144PDPK10.24829381
145PRKAA10.24230689
146OBSCN0.22100785
147MARK10.22000617
148GRK50.21473345
149CSNK1A10.20656075
150CDK180.20221998
151CAMK2A0.19613940
152DAPK20.19459494
153EIF2AK30.18762454
154RPS6KB10.17932850
155CDK150.17460508
156CSNK1D0.16990600
157AKT10.13447189
158VRK20.12513040
159NTRK30.10454809
160CDK11A0.08180054

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001208.32379746
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.94083824
3Caffeine metabolism_Homo sapiens_hsa002322.50654000
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.47948764
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22436369
6RNA polymerase_Homo sapiens_hsa030202.19496678
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.12570206
8Fatty acid biosynthesis_Homo sapiens_hsa000612.02807703
9Butanoate metabolism_Homo sapiens_hsa006502.01697762
10Tryptophan metabolism_Homo sapiens_hsa003801.99578354
11Small cell lung cancer_Homo sapiens_hsa052221.99454765
12ECM-receptor interaction_Homo sapiens_hsa045121.99448431
13Retinol metabolism_Homo sapiens_hsa008301.97216980
14Olfactory transduction_Homo sapiens_hsa047401.92571013
15Adherens junction_Homo sapiens_hsa045201.92238608
16Ether lipid metabolism_Homo sapiens_hsa005651.92044097
17MicroRNAs in cancer_Homo sapiens_hsa052061.90261775
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87865879
19TGF-beta signaling pathway_Homo sapiens_hsa043501.85952004
20Focal adhesion_Homo sapiens_hsa045101.80468675
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79183898
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76983616
23Propanoate metabolism_Homo sapiens_hsa006401.76835593
24p53 signaling pathway_Homo sapiens_hsa041151.73550732
25Prostate cancer_Homo sapiens_hsa052151.66167584
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62696899
27Chronic myeloid leukemia_Homo sapiens_hsa052201.56805863
28Pancreatic cancer_Homo sapiens_hsa052121.50293524
29Proteoglycans in cancer_Homo sapiens_hsa052051.50219380
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45881752
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40043052
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.37569656
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.37528832
34FoxO signaling pathway_Homo sapiens_hsa040681.35955132
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34453957
36TNF signaling pathway_Homo sapiens_hsa046681.33107602
37Hepatitis B_Homo sapiens_hsa051611.30792876
38Malaria_Homo sapiens_hsa051441.26687594
39Hippo signaling pathway_Homo sapiens_hsa043901.26570435
40Melanoma_Homo sapiens_hsa052181.25811962
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25152555
42Toxoplasmosis_Homo sapiens_hsa051451.24752453
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24363937
44Linoleic acid metabolism_Homo sapiens_hsa005911.20244864
45Osteoclast differentiation_Homo sapiens_hsa043801.19843433
46Phototransduction_Homo sapiens_hsa047441.16945474
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16616916
48HTLV-I infection_Homo sapiens_hsa051661.15873004
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15242089
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14494301
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13375685
52Renal cell carcinoma_Homo sapiens_hsa052111.12103788
53Dorso-ventral axis formation_Homo sapiens_hsa043201.11384727
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.10507206
55MAPK signaling pathway_Homo sapiens_hsa040101.10201848
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.09143015
57PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09102370
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08822798
59Amoebiasis_Homo sapiens_hsa051461.08587231
60Dilated cardiomyopathy_Homo sapiens_hsa054141.07771522
61Taste transduction_Homo sapiens_hsa047421.07588958
62Circadian rhythm_Homo sapiens_hsa047101.06754503
63Endometrial cancer_Homo sapiens_hsa052131.06403045
64Viral myocarditis_Homo sapiens_hsa054161.05570116
65ErbB signaling pathway_Homo sapiens_hsa040121.05364370
66Pathways in cancer_Homo sapiens_hsa052001.03978103
67Glycosaminoglycan degradation_Homo sapiens_hsa005311.02815658
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00968647
69Platelet activation_Homo sapiens_hsa046111.00787156
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00517092
71Glioma_Homo sapiens_hsa052141.00370098
72Leukocyte transendothelial migration_Homo sapiens_hsa046701.00082792
73Cell cycle_Homo sapiens_hsa041101.00000630
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.99508616
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97751604
76Nitrogen metabolism_Homo sapiens_hsa009100.95510352
77Apoptosis_Homo sapiens_hsa042100.93659087
78Wnt signaling pathway_Homo sapiens_hsa043100.93060286
79Salivary secretion_Homo sapiens_hsa049700.92957499
80Measles_Homo sapiens_hsa051620.90597460
81Colorectal cancer_Homo sapiens_hsa052100.89804596
82Prolactin signaling pathway_Homo sapiens_hsa049170.89342121
83Herpes simplex infection_Homo sapiens_hsa051680.88941592
84Leishmaniasis_Homo sapiens_hsa051400.88702902
85Notch signaling pathway_Homo sapiens_hsa043300.88693747
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88491286
87Bladder cancer_Homo sapiens_hsa052190.88227992
88Shigellosis_Homo sapiens_hsa051310.87981747
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86629113
90Tight junction_Homo sapiens_hsa045300.85828677
91Basal cell carcinoma_Homo sapiens_hsa052170.85599882
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85480702
93Axon guidance_Homo sapiens_hsa043600.85011547
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84644948
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84593936
96Rap1 signaling pathway_Homo sapiens_hsa040150.84414070
97Gastric acid secretion_Homo sapiens_hsa049710.83014512
98cAMP signaling pathway_Homo sapiens_hsa040240.82756386
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82747769
100Chemical carcinogenesis_Homo sapiens_hsa052040.82465819
101Viral carcinogenesis_Homo sapiens_hsa052030.81452926
102Ras signaling pathway_Homo sapiens_hsa040140.80452126
103Acute myeloid leukemia_Homo sapiens_hsa052210.80299439
104PPAR signaling pathway_Homo sapiens_hsa033200.79557414
105mRNA surveillance pathway_Homo sapiens_hsa030150.79463207
106ABC transporters_Homo sapiens_hsa020100.79406877
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78761030
108Morphine addiction_Homo sapiens_hsa050320.77285215
109Fanconi anemia pathway_Homo sapiens_hsa034600.76449052
110Insulin resistance_Homo sapiens_hsa049310.75968092
111Purine metabolism_Homo sapiens_hsa002300.75957770
112Glutamatergic synapse_Homo sapiens_hsa047240.75707506
113Nicotine addiction_Homo sapiens_hsa050330.75637096
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.75475972
115Chemokine signaling pathway_Homo sapiens_hsa040620.74835939
116B cell receptor signaling pathway_Homo sapiens_hsa046620.74505400
117Non-small cell lung cancer_Homo sapiens_hsa052230.74342921
118Ovarian steroidogenesis_Homo sapiens_hsa049130.72035071
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71633765
120T cell receptor signaling pathway_Homo sapiens_hsa046600.71054239
121Choline metabolism in cancer_Homo sapiens_hsa052310.69502677
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.69242908
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.68505356
124Salmonella infection_Homo sapiens_hsa051320.68437728
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67843158
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66220544
127Protein digestion and absorption_Homo sapiens_hsa049740.65657533
128Influenza A_Homo sapiens_hsa051640.63312257
129Long-term depression_Homo sapiens_hsa047300.63218699
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62767886
131Sphingolipid metabolism_Homo sapiens_hsa006000.62660395
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62175393
133Hepatitis C_Homo sapiens_hsa051600.61956292
134Vitamin B6 metabolism_Homo sapiens_hsa007500.61395796
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61060465
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60783155
137HIF-1 signaling pathway_Homo sapiens_hsa040660.60021933
138mTOR signaling pathway_Homo sapiens_hsa041500.59959388
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.59385931
140GnRH signaling pathway_Homo sapiens_hsa049120.59167235
141N-Glycan biosynthesis_Homo sapiens_hsa005100.57599783
142Hedgehog signaling pathway_Homo sapiens_hsa043400.57057426
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56765824
144Lysine degradation_Homo sapiens_hsa003100.55030559
145Renin-angiotensin system_Homo sapiens_hsa046140.54629236
146Epstein-Barr virus infection_Homo sapiens_hsa051690.54375355
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54063509
148Basal transcription factors_Homo sapiens_hsa030220.53862398
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.53756390
150Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53446963
151Thyroid cancer_Homo sapiens_hsa052160.52937029
152Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52668911
153Homologous recombination_Homo sapiens_hsa034400.50404753
154Insulin secretion_Homo sapiens_hsa049110.45595018
155Pyrimidine metabolism_Homo sapiens_hsa002400.44850169
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43917611
157beta-Alanine metabolism_Homo sapiens_hsa004100.42893918
158Calcium signaling pathway_Homo sapiens_hsa040200.42863983
159Circadian entrainment_Homo sapiens_hsa047130.42699121
160Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42498196
161Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42170127
162Non-homologous end-joining_Homo sapiens_hsa034500.41006174
163Fatty acid degradation_Homo sapiens_hsa000710.39223420
164Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38687801
165Renin secretion_Homo sapiens_hsa049240.38667605
166GABAergic synapse_Homo sapiens_hsa047270.37049822
167Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35860802
168Vascular smooth muscle contraction_Homo sapiens_hsa042700.35578658
169Glycerolipid metabolism_Homo sapiens_hsa005610.35203085
170Oxytocin signaling pathway_Homo sapiens_hsa049210.34936562
171Pyruvate metabolism_Homo sapiens_hsa006200.33088542
172Starch and sucrose metabolism_Homo sapiens_hsa005000.32144282
173Mineral absorption_Homo sapiens_hsa049780.31845279
174Peroxisome_Homo sapiens_hsa041460.29814753
175Cocaine addiction_Homo sapiens_hsa050300.27134029
176Metabolic pathways_Homo sapiens_hsa011000.26597173
177Type II diabetes mellitus_Homo sapiens_hsa049300.25437002

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