TSC22D3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.63965404
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.63965404
3tolerance induction (GO:0002507)6.25775339
4response to muramyl dipeptide (GO:0032495)4.44950271
5antigen processing and presentation of endogenous antigen (GO:0019883)4.29273080
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.24144331
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24144331
8regulation of germinal center formation (GO:0002634)4.17826892
9negative regulation of lymphocyte mediated immunity (GO:0002707)3.95153281
10neutrophil activation (GO:0042119)3.94851095
11negative regulation of T cell mediated immunity (GO:0002710)3.89777102
12regulation of T cell mediated cytotoxicity (GO:0001914)3.89273282
13positive T cell selection (GO:0043368)3.77040363
14positive regulation of T cell mediated cytotoxicity (GO:0001916)3.74276704
15negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.69765765
16thymic T cell selection (GO:0045061)3.68616583
17regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.67413080
18regulation of alpha-beta T cell proliferation (GO:0046640)3.66495757
19leukocyte aggregation (GO:0070486)3.66489765
20T cell selection (GO:0045058)3.65089668
21negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.64856734
22regulation of regulatory T cell differentiation (GO:0045589)3.64724415
23negative regulation of innate immune response (GO:0045824)3.61096268
24immunoglobulin mediated immune response (GO:0016064)3.56378296
25negative regulation of leukocyte mediated immunity (GO:0002704)3.51639321
26antigen processing and presentation via MHC class Ib (GO:0002475)3.48735009
27granulocyte activation (GO:0036230)3.44254731
28positive regulation of gamma-delta T cell activation (GO:0046645)3.43962087
29positive regulation of alpha-beta T cell proliferation (GO:0046641)3.38167945
30sleep (GO:0030431)3.33419125
31interferon-gamma production (GO:0032609)3.32795046
32positive regulation of granulocyte differentiation (GO:0030854)3.31312952
33regulation of B cell receptor signaling pathway (GO:0050855)3.30842762
34dendritic cell chemotaxis (GO:0002407)3.30649751
35L-phenylalanine catabolic process (GO:0006559)3.29271276
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.29271276
37positive regulation of T cell differentiation in thymus (GO:0033089)3.27572989
38regulation of leukocyte mediated cytotoxicity (GO:0001910)3.21966112
39regulation of T cell receptor signaling pathway (GO:0050856)3.21393906
40antigen receptor-mediated signaling pathway (GO:0050851)3.20813238
41T cell migration (GO:0072678)3.20231368
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20141283
43negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.19863244
44negative regulation of T-helper cell differentiation (GO:0045623)3.19863244
45RNA destabilization (GO:0050779)3.15197011
46leukocyte degranulation (GO:0043299)3.10580461
47regulation of natural killer cell mediated immunity (GO:0002715)3.09984108
48regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.09984108
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.09621305
50T-helper cell differentiation (GO:0042093)3.09536530
51CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.09536530
52T cell receptor signaling pathway (GO:0050852)3.08570429
53positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.02796701
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01966651
55regulation of antigen processing and presentation (GO:0002577)3.01489429
56regulation of cell killing (GO:0031341)3.00594551
57negative regulation of interleukin-1 beta production (GO:0032691)3.00423884
58dendritic cell migration (GO:0036336)2.99832358
59L-phenylalanine metabolic process (GO:0006558)2.99553625
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.99553625
61regulation of T cell mediated immunity (GO:0002709)2.96779213
62regulation of mast cell degranulation (GO:0043304)2.95492625
63negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.95417431
64mast cell degranulation (GO:0043303)2.95397516
65mast cell activation involved in immune response (GO:0002279)2.95397516
66complement activation, alternative pathway (GO:0006957)2.94342079
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94009798
68mucosal-associated lymphoid tissue development (GO:0048537)2.93702885
69Peyers patch development (GO:0048541)2.93702885
70alpha-beta T cell differentiation (GO:0046632)2.93519124
71negative regulation of bone resorption (GO:0045779)2.91081911
72positive regulation of T cell mediated immunity (GO:0002711)2.89327178
73B cell homeostasis (GO:0001782)2.88914692
74regulation of gamma-delta T cell differentiation (GO:0045586)2.88818355
75B cell mediated immunity (GO:0019724)2.86164625
76myeloid cell activation involved in immune response (GO:0002275)2.85950367
77defense response to protozoan (GO:0042832)2.85821188
78regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.85733870
79positive regulation of B cell differentiation (GO:0045579)2.85489456
80activated T cell proliferation (GO:0050798)2.83546976
81alpha-beta T cell activation (GO:0046631)2.83094041
82regulation of alpha-beta T cell activation (GO:0046634)2.80581229
83regulation of mast cell activation (GO:0033003)2.80483210
84positive regulation of mast cell activation (GO:0033005)2.80073021
85modulation by symbiont of host immune response (GO:0052553)2.79667870
86positive regulation by symbiont of host defense response (GO:0052509)2.79667870
87modulation by symbiont of host defense response (GO:0052031)2.79667870
88modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79667870
89modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79667870
90positive regulation by organism of defense response of other organism involved in symbiotic interact2.79667870
91positive regulation of respiratory burst (GO:0060267)2.78032610
92alpha-linolenic acid metabolic process (GO:0036109)2.73971177
93aromatic amino acid family catabolic process (GO:0009074)2.71984436
94B cell receptor signaling pathway (GO:0050853)2.71446465
95valine metabolic process (GO:0006573)2.63469364
96regulation of gamma-delta T cell activation (GO:0046643)2.61286997
97regulation of protein activation cascade (GO:2000257)2.59509907
98regulation of complement activation (GO:0030449)2.59269272
99negative regulation of erythrocyte differentiation (GO:0045647)2.57891679
100regulation of B cell differentiation (GO:0045577)2.57066801
101negative regulation of humoral immune response (GO:0002921)2.54267543
102negative regulation of complement activation (GO:0045916)2.52903393
103phospholipid efflux (GO:0033700)2.50061203
104complement activation (GO:0006956)2.49221068
105negative regulation of protein activation cascade (GO:2000258)2.48400420
106negative regulation of protein autophosphorylation (GO:0031953)2.46702358
107complement activation, classical pathway (GO:0006958)2.45623078
108G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.42365893
109regulation of triglyceride catabolic process (GO:0010896)2.41806395
110indole-containing compound catabolic process (GO:0042436)2.40994952
111indolalkylamine catabolic process (GO:0046218)2.40994952
112tryptophan catabolic process (GO:0006569)2.40994952
113very long-chain fatty acid metabolic process (GO:0000038)2.40419296
114cellular extravasation (GO:0045123)2.39022352
115positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.38995229
116amyloid precursor protein catabolic process (GO:0042987)2.37560356
117low-density lipoprotein particle remodeling (GO:0034374)2.36378272
118regulation of humoral immune response (GO:0002920)2.35378811
119negative T cell selection (GO:0043383)2.35033413
120triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.34630426
121surfactant homeostasis (GO:0043129)2.34446726
122ethanol oxidation (GO:0006069)2.32808757
123negative thymic T cell selection (GO:0045060)2.31984267
124definitive hemopoiesis (GO:0060216)2.30380030
125creatine metabolic process (GO:0006600)2.30295252
126bile acid biosynthetic process (GO:0006699)2.28249703
127regulation of cholesterol esterification (GO:0010872)2.26370394
128fatty acid catabolic process (GO:0009062)2.26320906
129fatty acid beta-oxidation (GO:0006635)2.26197667
130membrane raft organization (GO:0031579)2.25875012
131lipid oxidation (GO:0034440)2.25580976
132response to interleukin-15 (GO:0070672)2.25571224
133response to laminar fluid shear stress (GO:0034616)2.25248805
134positive regulation of antigen processing and presentation (GO:0002579)2.23759939
135regulation of T cell tolerance induction (GO:0002664)2.23609609
136fatty acid oxidation (GO:0019395)2.23430615
137regulation of interleukin-12 biosynthetic process (GO:0045075)2.22495223
138regulation of relaxation of muscle (GO:1901077)2.21929613
139kynurenine metabolic process (GO:0070189)2.20295472
140opsonization (GO:0008228)2.19618606
141response to mercury ion (GO:0046689)2.18818749
142neutrophil activation involved in immune response (GO:0002283)2.18479099
143detection of bacterium (GO:0016045)2.17744910
144cellular response to interleukin-15 (GO:0071350)2.17148752
145tryptophan metabolic process (GO:0006568)2.17065654
146protein activation cascade (GO:0072376)2.16623147
147detection of other organism (GO:0098543)2.16590961
148negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.14687361
149fatty acid elongation (GO:0030497)2.13443221
150blood vessel maturation (GO:0001955)2.13367432
151positive thymic T cell selection (GO:0045059)2.11466300
152monocarboxylic acid catabolic process (GO:0072329)2.10702351
153mature B cell differentiation involved in immune response (GO:0002313)2.09635760
154regulation of respiratory burst (GO:0060263)2.07972798
155regulation of cholesterol metabolic process (GO:0090181)2.07942666
156fatty acid transmembrane transport (GO:1902001)2.07118038
157mature B cell differentiation (GO:0002335)2.05809273
158negative regulation of lipase activity (GO:0060192)2.05431550
159keratan sulfate catabolic process (GO:0042340)2.03378855
160regulation of extracellular matrix disassembly (GO:0010715)2.02479437
161angiogenesis involved in wound healing (GO:0060055)2.02170737
162peptidyl-glutamic acid carboxylation (GO:0017187)2.01770460
163protein carboxylation (GO:0018214)2.01770460
164ethanol metabolic process (GO:0006067)2.00968779
165regulation of cholesterol biosynthetic process (GO:0045540)1.99508583
166regulation of dendritic cell antigen processing and presentation (GO:0002604)1.99140834
167mast cell activation (GO:0045576)1.99092610
1682-oxoglutarate metabolic process (GO:0006103)1.98630259
169negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.98356125
170macrophage differentiation (GO:0030225)1.97220307
171high-density lipoprotein particle remodeling (GO:0034375)1.96755457
172reverse cholesterol transport (GO:0043691)1.96651050
173positive regulation of sterol transport (GO:0032373)1.96269042
174positive regulation of cholesterol transport (GO:0032376)1.96269042
175lymph vessel development (GO:0001945)1.95829516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.13652831
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.79605938
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.68684601
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06182077
5GATA1_22025678_ChIP-Seq_K562_Human2.86001717
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.66258160
7RUNX_20019798_ChIP-Seq_JUKART_Human2.65156111
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.60487108
9SCL_19346495_ChIP-Seq_HPC-7_Human2.42227980
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.36089114
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30958020
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24958919
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.22648771
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16606381
15GATA2_21666600_ChIP-Seq_HMVEC_Human2.15905331
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.15223557
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14461342
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10599450
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07031612
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.00479579
21MYC_22102868_ChIP-Seq_BL_Human1.98095349
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.96730464
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.94537688
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82985057
25* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82384639
26MAF_26560356_Chip-Seq_TH2_Human1.80561844
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77276478
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75737731
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75643933
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67036927
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65849681
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60110130
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56638228
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54980782
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52693390
36* CLOCK_20551151_ChIP-Seq_293T_Human1.47477529
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.44819785
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43325679
39GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42898557
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42183211
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.40473784
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37180669
43MAF_26560356_Chip-Seq_TH1_Human1.36509871
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35414593
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35056293
46GATA1_19941826_ChIP-Seq_K562_Human1.34958109
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.33963554
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32303522
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32004946
50EGR1_19032775_ChIP-ChIP_M12_Human1.31469441
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30212607
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29949893
53GATA2_19941826_ChIP-Seq_K562_Human1.29903800
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28864741
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.27944783
56VDR_24787735_ChIP-Seq_THP-1_Human1.27451242
57MYB_26560356_Chip-Seq_TH2_Human1.26977199
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24093108
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23311672
60BCL6_27268052_Chip-Seq_Bcells_Human1.22524894
61KDM2B_26808549_Chip-Seq_DND41_Human1.21170799
62CIITA_25753668_ChIP-Seq_RAJI_Human1.20077262
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17592620
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16826905
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15214864
66* ESR2_21235772_ChIP-Seq_MCF-7_Human1.14948744
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12606775
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11799596
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11573695
70* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11274005
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11098674
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10951053
73SPI1_23127762_ChIP-Seq_K562_Human1.10613758
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10113434
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.07824186
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07382849
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06811333
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06045028
79GATA3_27048872_Chip-Seq_THYMUS_Human1.05310229
80MYB_26560356_Chip-Seq_TH1_Human1.04898346
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04770894
82VDR_24763502_ChIP-Seq_THP-1_Human1.03419496
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02844735
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02260669
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01808690
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01733547
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00471470
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.00161825
89KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98571998
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97969767
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97412139
92BCOR_27268052_Chip-Seq_Bcells_Human0.96827248
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95852975
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95700421
95* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95592534
96FOXO3_23340844_ChIP-Seq_DLD1_Human0.95471908
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95410582
98* RUNX1_22412390_ChIP-Seq_EML_Mouse0.94000374
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93457908
100P300_27268052_Chip-Seq_Bcells_Human0.93439157
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.92340857
102* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91941658
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91919555
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91850502
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89481598
106SOX2_20726797_ChIP-Seq_SW620_Human0.88919812
107UTX_26944678_Chip-Seq_JUKART_Human0.88596256
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88190778
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88190778
110CJUN_26792858_Chip-Seq_BT549_Human0.87866869
111GATA3_26560356_Chip-Seq_TH2_Human0.86357553
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86129336
113SMRT_27268052_Chip-Seq_Bcells_Human0.85222722
114* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85179261
115AR_21572438_ChIP-Seq_LNCaP_Human0.84504990
116TAF15_26573619_Chip-Seq_HEK293_Human0.84233631
117* ESR1_21235772_ChIP-Seq_MCF-7_Human0.83712985
118KDM2B_26808549_Chip-Seq_JURKAT_Human0.83541780
119TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83521422
120SPI1_20517297_ChIP-Seq_HL60_Human0.82566701
121PU_27001747_Chip-Seq_BMDM_Mouse0.81257856
122* SPI1_23547873_ChIP-Seq_NB4_Human0.81073318
123* TBX20_22328084_ChIP-Seq_HEART_Mouse0.80796861
124* TBX20_22080862_ChIP-Seq_HEART_Mouse0.80796861
125CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80692563
126STAT1_20625510_ChIP-Seq_HELA_Human0.79620093
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.79036353
128CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78852713
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78808340
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.77959041
131VDR_21846776_ChIP-Seq_THP-1_Human0.77951514
132SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.75151494
133CDX2_20551321_ChIP-Seq_CACO-2_Human0.74414061
134* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74110043
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73781858
136IKZF1_21737484_ChIP-ChIP_HCT116_Human0.73639457
137* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72855246
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72815674
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.72575402
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72569910
141TCF7_22412390_ChIP-Seq_EML_Mouse0.71753116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation2.89172239
2MP0003191_abnormal_cellular_cholesterol2.87309563
3MP0002009_preneoplasia2.62410764
4MP0002139_abnormal_hepatobiliary_system2.58666431
5MP0003724_increased_susceptibility_to2.54787589
6MP0002837_dystrophic_cardiac_calcinosis2.32475340
7MP0000685_abnormal_immune_system2.24645985
8MP0005671_abnormal_response_to2.24200274
9MP0001790_abnormal_immune_system2.20764141
10MP0005387_immune_system_phenotype2.20764141
11MP0010368_abnormal_lymphatic_system2.20341845
12MP0008875_abnormal_xenobiotic_pharmacok2.18023366
13MP0005360_urolithiasis2.15371792
14MP0005365_abnormal_bile_salt2.11031863
15MP0003436_decreased_susceptibility_to1.99635509
16MP0001800_abnormal_humoral_immune1.97008394
17MP0009785_altered_susceptibility_to1.88747352
18MP0005085_abnormal_gallbladder_physiolo1.88715591
19MP0000703_abnormal_thymus_morphology1.85286394
20MP0003866_abnormal_defecation1.81415946
21MP0002933_joint_inflammation1.80958701
22MP0005464_abnormal_platelet_physiology1.80534098
23MP0009840_abnormal_foam_cell1.76625678
24MP0002419_abnormal_innate_immunity1.76336638
25MP0005058_abnormal_lysosome_morphology1.72504979
26MP0003279_aneurysm1.70443852
27MP0009333_abnormal_splenocyte_physiolog1.69502972
28MP0001853_heart_inflammation1.68048750
29MP0010329_abnormal_lipoprotein_level1.67936795
30MP0005075_abnormal_melanosome_morpholog1.67429007
31MP0002452_abnormal_antigen_presenting1.66647379
32MP0005000_abnormal_immune_tolerance1.65134724
33MP0005025_abnormal_response_to1.62110647
34MP0003690_abnormal_glial_cell1.61970759
35MP0001879_abnormal_lymphatic_vessel1.61509937
36MP0001873_stomach_inflammation1.60598381
37MP0002138_abnormal_hepatobiliary_system1.60510100
38MP0000465_gastrointestinal_hemorrhage1.57770001
39MP0002723_abnormal_immune_serum1.57479089
40MP0002166_altered_tumor_susceptibility1.56627265
41MP0000343_altered_response_to1.56620160
42MP0004036_abnormal_muscle_relaxation1.56466038
43MP0002148_abnormal_hypersensitivity_rea1.54529241
44MP0004130_abnormal_muscle_cell1.53277139
45MP0002420_abnormal_adaptive_immunity1.52691407
46MP0003763_abnormal_thymus_physiology1.51882976
47MP0001533_abnormal_skeleton_physiology1.50095784
48MP0001819_abnormal_immune_cell1.49464138
49MP0006082_CNS_inflammation1.46701205
50MP0005670_abnormal_white_adipose1.46031995
51MP0002254_reproductive_system_inflammat1.45983086
52MP0002006_tumorigenesis1.44168750
53MP0005167_abnormal_blood-brain_barrier1.40193042
54MP0003075_altered_response_to1.38883053
55MP0000920_abnormal_myelination1.33801623
56MP0004510_myositis1.29693636
57MP0001501_abnormal_sleep_pattern1.25558211
58MP0008469_abnormal_protein_level1.23243109
59MP0005397_hematopoietic_system_phenotyp1.21584028
60MP0001545_abnormal_hematopoietic_system1.21584028
61MP0009764_decreased_sensitivity_to1.20842314
62MP0000751_myopathy1.18967059
63MP0001845_abnormal_inflammatory_respons1.18820213
64MP0002396_abnormal_hematopoietic_system1.18794000
65MP0002118_abnormal_lipid_homeostasis1.18783865
66MP0005584_abnormal_enzyme/coenzyme_acti1.18595283
67MP0003300_gastrointestinal_ulcer1.17480372
68MP0005310_abnormal_salivary_gland1.17057218
69MP0001764_abnormal_homeostasis1.16364921
70MP0001986_abnormal_taste_sensitivity1.15642257
71MP0003252_abnormal_bile_duct1.14887440
72MP0000749_muscle_degeneration1.14353075
73MP0003303_peritoneal_inflammation1.13802824
74MP0003656_abnormal_erythrocyte_physiolo1.13033745
75MP0005332_abnormal_amino_acid1.12750150
76MP0000716_abnormal_immune_system1.12022546
77MP0004381_abnormal_hair_follicle1.10740343
78MP0000249_abnormal_blood_vessel1.09377621
79MP0009278_abnormal_bone_marrow1.08439407
80MP0000609_abnormal_liver_physiology1.08049401
81MP0002405_respiratory_system_inflammati1.07749230
82MP0004147_increased_porphyrin_level1.07723763
83MP0004883_abnormal_blood_vessel1.06655615
84MP0005390_skeleton_phenotype1.06632327
85MP0004084_abnormal_cardiac_muscle1.06443176
86MP0000689_abnormal_spleen_morphology1.02815115
87MP0001958_emphysema1.01888758
88MP0010155_abnormal_intestine_physiology1.01758663
89MP0001666_abnormal_nutrient_absorption1.01282248
90MP0002132_abnormal_respiratory_system0.98793964
91MP0009384_cardiac_valve_regurgitation0.97653194
92MP0002398_abnormal_bone_marrow0.97454187
93MP0000858_altered_metastatic_potential0.97220815
94MP0001851_eye_inflammation0.96265023
95MP0003828_pulmonary_edema0.95267292
96MP0005166_decreased_susceptibility_to0.93399250
97MP0003172_abnormal_lysosome_physiology0.91251212
98MP0009763_increased_sensitivity_to0.89634045
99MP0008874_decreased_physiological_sensi0.86635051
100MP0005165_increased_susceptibility_to0.85908480
101MP0004947_skin_inflammation0.85853327
102MP0003183_abnormal_peptide_metabolism0.85636069
103MP0003011_delayed_dark_adaptation0.85602189
104MP0005164_abnormal_response_to0.85264042
105MP0005319_abnormal_enzyme/_coenzyme0.84618611
106MP0002429_abnormal_blood_cell0.84495881
107MP0006054_spinal_hemorrhage0.83482488
108MP0002998_abnormal_bone_remodeling0.82962810
109MP0009643_abnormal_urine_homeostasis0.82193769
110MP0003646_muscle_fatigue0.80931010
111MP0003806_abnormal_nucleotide_metabolis0.80733223
112MP0002722_abnormal_immune_system0.80639808
113MP0002277_abnormal_respiratory_mucosa0.80008248
114MP0002876_abnormal_thyroid_physiology0.79625659
115MP0000230_abnormal_systemic_arterial0.79448263
116MP0000604_amyloidosis0.78663426
117MP0008961_abnormal_basal_metabolism0.74895081
118MP0005666_abnormal_adipose_tissue0.74695467
119MP0004145_abnormal_muscle_electrophysio0.74248064
120MP0004484_altered_response_of0.73449153
121MP0006138_congestive_heart_failure0.72764792
122MP0008995_early_reproductive_senescence0.69056720
123MP0002019_abnormal_tumor_incidence0.68395920
124MP0003795_abnormal_bone_structure0.64205944
125MP0001919_abnormal_reproductive_system0.63036718
126MP0001765_abnormal_ion_homeostasis0.62870995
127MP0009765_abnormal_xenobiotic_induced0.61672497
128MP0003638_abnormal_response/metabolism_0.61236746
129MP0001663_abnormal_digestive_system0.58336349
130MP0003448_altered_tumor_morphology0.53372987
131MP0000015_abnormal_ear_pigmentation0.50881633
132MP0002136_abnormal_kidney_physiology0.50018359
133MP0005174_abnormal_tail_pigmentation0.49703636
134MP0004808_abnormal_hematopoietic_stem0.49464855
135MP0002928_abnormal_bile_duct0.47652803
136MP0005084_abnormal_gallbladder_morpholo0.46640552
137MP0008260_abnormal_autophagy0.45781516
138MP0008872_abnormal_physiological_respon0.45033502
139MP0005535_abnormal_body_temperature0.43505597

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.59287759
2IgG deficiency (HP:0004315)4.80787499
3Retrobulbar optic neuritis (HP:0100654)4.50162848
4Optic neuritis (HP:0100653)4.50162848
5Stomach cancer (HP:0012126)4.37277595
6Severe combined immunodeficiency (HP:0004430)4.25723152
7Abnormality of T cells (HP:0002843)4.12710875
8Recurrent fungal infections (HP:0002841)4.01270809
9Abnormality of B cell number (HP:0010975)3.79942969
10Spontaneous hematomas (HP:0007420)3.79874665
11Systemic lupus erythematosus (HP:0002725)3.77663981
12Abnormality of T cell physiology (HP:0011840)3.76983652
13Mediastinal lymphadenopathy (HP:0100721)3.76430601
14Complement deficiency (HP:0004431)3.74362541
15Abnormality of eosinophils (HP:0001879)3.63825120
16Granulocytopenia (HP:0001913)3.54269420
17B lymphocytopenia (HP:0010976)3.47557092
18Gastrointestinal infarctions (HP:0005244)3.47376760
19Pustule (HP:0200039)3.45800222
20Abnormality of the prostate (HP:0008775)3.40600266
21Leukocytosis (HP:0001974)3.37737955
22Pulmonary infiltrates (HP:0002113)3.33401832
23Eosinophilia (HP:0001880)3.32384589
24Encephalitis (HP:0002383)3.31451070
25Prostate neoplasm (HP:0100787)3.30130502
26Chronic mucocutaneous candidiasis (HP:0002728)3.25275668
27Recurrent cutaneous fungal infections (HP:0011370)3.25275668
28Combined immunodeficiency (HP:0005387)3.15990770
29Autoimmune hemolytic anemia (HP:0001890)3.12190086
30Increased IgE level (HP:0003212)3.07269511
31Obstructive lung disease (HP:0006536)3.06638288
32Chronic obstructive pulmonary disease (HP:0006510)3.06638288
33Abnormality of macrophages (HP:0004311)3.00467074
34Agammaglobulinemia (HP:0004432)2.91279040
35Abnormality of aromatic amino acid family metabolism (HP:0004338)2.88843944
36Glomerulonephritis (HP:0000099)2.88118295
37Increased IgM level (HP:0003496)2.87212788
38Chronic otitis media (HP:0000389)2.86400246
39Deep venous thrombosis (HP:0002625)2.83242836
40Chest pain (HP:0100749)2.75135675
41Hemoptysis (HP:0002105)2.74422427
42Exercise-induced myalgia (HP:0003738)2.73776000
43Recurrent abscess formation (HP:0002722)2.72256420
44Amyloidosis (HP:0011034)2.70391554
45Recurrent bacterial skin infections (HP:0005406)2.68682054
46Thyroiditis (HP:0100646)2.67889750
47Joint swelling (HP:0001386)2.64217550
48Hyperlipoproteinemia (HP:0010980)2.63288627
49Abnormality of complement system (HP:0005339)2.62230660
50Arterial thrombosis (HP:0004420)2.61447116
51Lymphopenia (HP:0001888)2.60785204
52Joint hemorrhage (HP:0005261)2.58363126
53Elevated erythrocyte sedimentation rate (HP:0003565)2.55637690
54Cerebral hemorrhage (HP:0001342)2.54641829
55Xanthomatosis (HP:0000991)2.53329094
56Epiphyseal dysplasia (HP:0002656)2.52476984
57Autoimmune thrombocytopenia (HP:0001973)2.51603161
58Recurrent bronchitis (HP:0002837)2.48647409
59Purpura (HP:0000979)2.48040087
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.46338223
61Epistaxis (HP:0000421)2.43866931
62Recurrent sinusitis (HP:0011108)2.43444114
63Urticaria (HP:0001025)2.42258895
64Abnormality of the nasal mucosa (HP:0000433)2.39682956
65Colitis (HP:0002583)2.37685822
66Arthropathy (HP:0003040)2.37155542
67Mitral stenosis (HP:0001718)2.36864157
68Gangrene (HP:0100758)2.35835937
69Pulmonary embolism (HP:0002204)2.34993129
70Prolonged bleeding time (HP:0003010)2.33094606
71Myositis (HP:0100614)2.32502917
72Abnormality of fatty-acid metabolism (HP:0004359)2.32493918
73Glomerulopathy (HP:0100820)2.32273386
74Alveolar cell carcinoma (HP:0006519)2.29276544
75Hypergammaglobulinemia (HP:0010702)2.28713235
76Vacuolated lymphocytes (HP:0001922)2.28679810
77Eczematoid dermatitis (HP:0000976)2.28106824
78Abnormal tarsal ossification (HP:0008369)2.26885813
79Anorexia (HP:0002039)2.25881012
80Gingival bleeding (HP:0000225)2.25140534
81Abnormality of the pleura (HP:0002103)2.24020573
82Inflammation of the large intestine (HP:0002037)2.22455953
83Abnormal foot bone ossification (HP:0010675)2.22130275
84Facial diplegia (HP:0001349)2.21029602
85Hematochezia (HP:0002573)2.20633599
86Growth hormone excess (HP:0000845)2.20331794
87Gastrointestinal stroma tumor (HP:0100723)2.20108994
88Recurrent gram-negative bacterial infections (HP:0005420)2.19883976
89Pulmonary fibrosis (HP:0002206)2.17551251
90Episodic fever (HP:0001954)2.16150173
91Intrahepatic cholestasis (HP:0001406)2.14357769
92Muscle fiber inclusion bodies (HP:0100299)2.14315807
93Abnormality of male internal genitalia (HP:0000022)2.13361896
94Cellulitis (HP:0100658)2.13347228
95Recurrent skin infections (HP:0001581)2.12744681
96Chronic diarrhea (HP:0002028)2.12440911
97Prolonged partial thromboplastin time (HP:0003645)2.11886282
98Hypochromic anemia (HP:0001931)2.11120395
99Vertigo (HP:0002321)2.09543816
100Papilledema (HP:0001085)2.08742005
101Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.08280306
102Osteomyelitis (HP:0002754)2.08190971
103Neoplasm of the tracheobronchial system (HP:0100552)2.08099390
104IgM deficiency (HP:0002850)2.07633590
105Nemaline bodies (HP:0003798)2.07068715
106Keratitis (HP:0000491)2.06315083
107Interstitial pulmonary disease (HP:0006530)2.05582840
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03901640
109Abnormality of the common coagulation pathway (HP:0010990)2.03760284
110Muscle fiber splitting (HP:0003555)2.02171364
111Abnormality of the lumbar spine (HP:0100712)2.00939532
112Asymmetric septal hypertrophy (HP:0001670)2.00362590
113Skin rash (HP:0000988)2.00266997
114Gastrointestinal inflammation (HP:0004386)1.97285717
115Arthralgia (HP:0002829)1.96622249
116Sepsis (HP:0100806)1.96106304
117Meningitis (HP:0001287)1.95927825
118Restrictive lung disease (HP:0002091)1.95137054
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.95016713
120Neutropenia (HP:0001875)1.93968798
121Fatigue (HP:0012378)1.92109620
122Stridor (HP:0010307)1.90760675
123Dysostosis multiplex (HP:0000943)1.89948004
124Nephritis (HP:0000123)1.88946132
125Type 1 muscle fiber predominance (HP:0003803)1.88726147
126Panhypogammaglobulinemia (HP:0003139)1.87797999
127Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.87705736
128Abnormal delayed hypersensitivity skin test (HP:0002963)1.87574607
129Bronchitis (HP:0012387)1.87484036
130Muscle hypertrophy of the lower extremities (HP:0008968)1.86725744
131Verrucae (HP:0200043)1.86353370
132Papilloma (HP:0012740)1.86353370
133Hepatosplenomegaly (HP:0001433)1.85870326
134Polycythemia (HP:0001901)1.85823069
135Gingivitis (HP:0000230)1.85277034
136Exercise-induced muscle cramps (HP:0003710)1.84915250
137Keratoconjunctivitis sicca (HP:0001097)1.84062337
138Myocardial infarction (HP:0001658)1.83305264
139Recurrent viral infections (HP:0004429)1.81789688
140Muscle stiffness (HP:0003552)1.81284822
141Abnormal platelet function (HP:0011869)1.81030723
142Impaired platelet aggregation (HP:0003540)1.81030723
143Barrel-shaped chest (HP:0001552)1.80127158
144Arterial tortuosity (HP:0005116)1.79619633
145Hypoalphalipoproteinemia (HP:0003233)1.78491476
146Calf muscle hypertrophy (HP:0008981)1.78043933
147Petechiae (HP:0000967)1.77385495
148T lymphocytopenia (HP:0005403)1.76966276
149Abnormality of T cell number (HP:0011839)1.76521114
150Vasculitis (HP:0002633)1.76485626
151Increased neuronal autofluorescent lipopigment (HP:0002074)1.75798356
152Hyporeflexia of lower limbs (HP:0002600)1.75586579
153Orchitis (HP:0100796)1.74601784
154Steatorrhea (HP:0002570)1.73804122
155Abnormality of the frontal sinuses (HP:0002687)1.73615150
156Metaphyseal dysplasia (HP:0100255)1.72187837
157Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.71634158
158Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.70909068
159Ulnar deviation of the wrist (HP:0003049)1.70748512
160Fat malabsorption (HP:0002630)1.69152953
161Ketosis (HP:0001946)1.68946103
162Keratoconjunctivitis (HP:0001096)1.67879507
163Nasal polyposis (HP:0100582)1.66601007
164Abnormal platelet volume (HP:0011876)1.66444908
165Thoracic kyphosis (HP:0002942)1.66206067
166Microcytic anemia (HP:0001935)1.65931455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.09742884
2MAP4K13.17059125
3RIPK43.05255262
4MAP2K22.71746811
5TIE12.70574641
6MAP2K32.40010970
7TEC2.08124371
8TXK1.96656230
9TYK21.93330054
10EPHB11.92940058
11FGFR41.83781417
12ITK1.75499145
13BTK1.71194261
14BCKDK1.70686298
15ERN11.65429047
16TESK21.63658201
17GRK71.61193246
18ZAP701.58559006
19KIT1.58195512
20STK101.54163872
21MYLK1.51356783
22CSF1R1.49802059
23MAPK121.49195040
24BLK1.45803496
25BMPR21.45578701
26IKBKE1.40916294
27JAK31.39517607
28JAK11.36500747
29SIK31.35745520
30MAP3K141.33779429
31MAP3K31.33285523
32MUSK1.32807317
33NLK1.25683222
34TBK11.24106706
35PIK3CG1.23360131
36MST41.20051859
37CSK1.17729349
38OBSCN1.16777503
39GRK61.16728700
40PHKG11.16359171
41PHKG21.16359171
42MAP3K121.15686143
43TTN1.15243315
44MAPK151.11098603
45STK241.08965846
46MARK31.08808802
47TNK21.08157836
48PIM11.07332201
49SYK1.06899625
50STK391.06832702
51MAP3K131.06823329
52TLK11.04780896
53FGFR31.02200521
54TRPM71.01558605
55KDR0.98728511
56CAMK1D0.98659852
57IKBKB0.97820675
58MAPK70.97581516
59LCK0.97275262
60LMTK20.96382048
61IRAK10.93780000
62HCK0.93770719
63GRK10.93439081
64FGFR20.91448627
65CLK10.91175416
66OXSR10.91142907
67IRAK40.90842474
68NEK90.89230943
69PRPF4B0.89153742
70LRRK20.88559359
71MAPKAPK50.88065583
72PRKG20.86980325
73INSRR0.86859213
74MAP2K60.86356589
75SIK20.84495165
76MAPK40.83375259
77MAP3K70.82970020
78PIK3CA0.81396386
79CAMKK20.79623629
80CAMK1G0.78643279
81PDK10.78477026
82PRKCH0.75433106
83FES0.75081232
84PRKCQ0.75047621
85JAK20.74302100
86TAOK30.73935833
87TGFBR10.73687918
88CAMKK10.72279510
89TRIB30.71591178
90SIK10.69494710
91SGK30.67001006
92MOS0.65581828
93PRKAA20.63779114
94CDK190.62917562
95EPHA30.62620357
96IGF1R0.61858282
97RPS6KA60.61214691
98RPS6KL10.61151317
99RPS6KC10.61151317
100LYN0.59985869
101IRAK30.59548194
102CDK40.59422933
103PDPK10.59303035
104MATK0.59263272
105MAP3K110.57994888
106PDK20.57960917
107PRKD10.57661107
108SGK4940.57274785
109SGK2230.57274785
110FLT30.55255546
111CHUK0.53469794
112PKN10.53210360
113RPS6KA20.52928778
114GRK50.51035985
115MAPK110.50795569
116MAP2K40.50780974
117HIPK20.50528703
118MAP3K10.49921934
119FYN0.49721130
120WNK10.49580451
121SGK20.49548560
122ARAF0.45241909
123ZAK0.45177680
124PRKD20.44113204
125MAP2K10.43940433
126MAPK30.43874750
127PASK0.42858912
128MAPKAPK20.42820412
129FGR0.42192681
130MARK20.41164046
131MAP4K20.40781831
132ABL10.40518123
133MAPKAPK30.39712115
134PINK10.39577456
135PTK2B0.35907666
136ADRBK20.32412407
137RPS6KA10.32147779
138PRKCD0.32088053
139EIF2AK20.29621603
140DAPK20.26721098
141IRAK20.25738011

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.19930304
2Graft-versus-host disease_Homo sapiens_hsa053323.12737894
3Staphylococcus aureus infection_Homo sapiens_hsa051502.79813884
4Caffeine metabolism_Homo sapiens_hsa002322.74136542
5Nitrogen metabolism_Homo sapiens_hsa009102.65812251
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.45627304
7Asthma_Homo sapiens_hsa053102.44784754
8Type I diabetes mellitus_Homo sapiens_hsa049402.31553705
9Complement and coagulation cascades_Homo sapiens_hsa046102.26141989
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.19379768
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05175270
12Primary immunodeficiency_Homo sapiens_hsa053402.01139101
13Fatty acid degradation_Homo sapiens_hsa000711.99817103
14Fatty acid elongation_Homo sapiens_hsa000621.97098447
15Antigen processing and presentation_Homo sapiens_hsa046121.96271824
16Propanoate metabolism_Homo sapiens_hsa006401.76479816
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75754265
18B cell receptor signaling pathway_Homo sapiens_hsa046621.69290568
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67815287
20Herpes simplex infection_Homo sapiens_hsa051681.66486503
21Viral myocarditis_Homo sapiens_hsa054161.63481056
22PPAR signaling pathway_Homo sapiens_hsa033201.61735390
23Tryptophan metabolism_Homo sapiens_hsa003801.61184910
24Histidine metabolism_Homo sapiens_hsa003401.59420714
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56993589
26Fatty acid metabolism_Homo sapiens_hsa012121.52135042
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52064572
28TNF signaling pathway_Homo sapiens_hsa046681.48263041
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44803367
30Peroxisome_Homo sapiens_hsa041461.44607440
31Arginine biosynthesis_Homo sapiens_hsa002201.41920260
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27081988
33Osteoclast differentiation_Homo sapiens_hsa043801.26244731
34Leishmaniasis_Homo sapiens_hsa051401.24307183
35Chemical carcinogenesis_Homo sapiens_hsa052041.21955498
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21808549
37Other glycan degradation_Homo sapiens_hsa005111.21258443
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.20527745
39ABC transporters_Homo sapiens_hsa020101.19417874
40beta-Alanine metabolism_Homo sapiens_hsa004101.15224808
41Influenza A_Homo sapiens_hsa051641.14823750
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13219204
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11858077
44Legionellosis_Homo sapiens_hsa051341.08775170
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06828621
46Platelet activation_Homo sapiens_hsa046111.05596173
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05262872
48Retinol metabolism_Homo sapiens_hsa008301.02897925
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01375540
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.98216202
51Hematopoietic cell lineage_Homo sapiens_hsa046400.97382160
52Starch and sucrose metabolism_Homo sapiens_hsa005000.96617654
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92763229
54Pertussis_Homo sapiens_hsa051330.91871207
55T cell receptor signaling pathway_Homo sapiens_hsa046600.91069812
56Butanoate metabolism_Homo sapiens_hsa006500.88863299
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.88821551
58Hepatitis B_Homo sapiens_hsa051610.88736857
59Apoptosis_Homo sapiens_hsa042100.87357767
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85805825
61Bile secretion_Homo sapiens_hsa049760.85795970
62Pyruvate metabolism_Homo sapiens_hsa006200.84778035
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81829751
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.81083609
65Phenylalanine metabolism_Homo sapiens_hsa003600.78123143
66Lysosome_Homo sapiens_hsa041420.77615961
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76657869
68Regulation of autophagy_Homo sapiens_hsa041400.75959847
69Non-small cell lung cancer_Homo sapiens_hsa052230.75583810
70Insulin resistance_Homo sapiens_hsa049310.75216785
71Sulfur metabolism_Homo sapiens_hsa009200.74616444
72Malaria_Homo sapiens_hsa051440.74308251
73Arachidonic acid metabolism_Homo sapiens_hsa005900.73986126
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73676307
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.73051609
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72459815
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72166262
78Epstein-Barr virus infection_Homo sapiens_hsa051690.71214631
79Toxoplasmosis_Homo sapiens_hsa051450.70936354
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70889637
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.70798452
82Chemokine signaling pathway_Homo sapiens_hsa040620.69499921
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69321059
84African trypanosomiasis_Homo sapiens_hsa051430.66639260
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.66425905
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65512374
87HTLV-I infection_Homo sapiens_hsa051660.62686993
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62390420
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59763716
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59550421
91Tyrosine metabolism_Homo sapiens_hsa003500.59319443
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.58806871
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58490685
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58108303
95Prolactin signaling pathway_Homo sapiens_hsa049170.56918194
96Measles_Homo sapiens_hsa051620.56730892
97Glycerolipid metabolism_Homo sapiens_hsa005610.54782028
98Circadian rhythm_Homo sapiens_hsa047100.54272323
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54183614
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53807835
101Phagosome_Homo sapiens_hsa041450.53729330
102Viral carcinogenesis_Homo sapiens_hsa052030.52246691
103Endocytosis_Homo sapiens_hsa041440.51195318
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50351083
105Choline metabolism in cancer_Homo sapiens_hsa052310.50088865
106Fatty acid biosynthesis_Homo sapiens_hsa000610.49055334
107Linoleic acid metabolism_Homo sapiens_hsa005910.48903440
108MAPK signaling pathway_Homo sapiens_hsa040100.47991160
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47766071
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46776383
111Acute myeloid leukemia_Homo sapiens_hsa052210.45029707
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.44876260
113Hepatitis C_Homo sapiens_hsa051600.43982862
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43935041
115Salmonella infection_Homo sapiens_hsa051320.43856865
116VEGF signaling pathway_Homo sapiens_hsa043700.43271066
117Ether lipid metabolism_Homo sapiens_hsa005650.43189234
118Sphingolipid metabolism_Homo sapiens_hsa006000.42991375
119Shigellosis_Homo sapiens_hsa051310.42085751
120ECM-receptor interaction_Homo sapiens_hsa045120.41949610
121Focal adhesion_Homo sapiens_hsa045100.40763043
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39705153
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38318614
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38114278
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.38011373
126FoxO signaling pathway_Homo sapiens_hsa040680.37893776
127Inositol phosphate metabolism_Homo sapiens_hsa005620.37782363
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.37265781
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36303937
130Arginine and proline metabolism_Homo sapiens_hsa003300.36141866
131Steroid biosynthesis_Homo sapiens_hsa001000.34969851
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34087084
133Tuberculosis_Homo sapiens_hsa051520.33908896
134Fat digestion and absorption_Homo sapiens_hsa049750.33776357
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33623051
136Autoimmune thyroid disease_Homo sapiens_hsa053200.33324318
137Vitamin digestion and absorption_Homo sapiens_hsa049770.32953821
138Rheumatoid arthritis_Homo sapiens_hsa053230.32745247
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32657249
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32171799
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32095107
142Pancreatic cancer_Homo sapiens_hsa052120.31874805
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31032768
144Renin secretion_Homo sapiens_hsa049240.30050778
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29920175
146Chronic myeloid leukemia_Homo sapiens_hsa052200.27501311
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24918737
148Oxytocin signaling pathway_Homo sapiens_hsa049210.23034060
149Colorectal cancer_Homo sapiens_hsa052100.22340849
150Olfactory transduction_Homo sapiens_hsa047400.21973807
151Morphine addiction_Homo sapiens_hsa050320.20410478
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.19155407

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