TSEN15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.94690087
2ribosomal small subunit assembly (GO:0000028)5.34504055
3telomere maintenance via semi-conservative replication (GO:0032201)4.95008137
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.90547607
5DNA strand elongation involved in DNA replication (GO:0006271)4.89797677
6DNA strand elongation (GO:0022616)4.67828135
7proteasome assembly (GO:0043248)4.56447872
8DNA replication initiation (GO:0006270)4.41935641
9telomere maintenance via recombination (GO:0000722)4.33977969
10viral transcription (GO:0019083)4.26369616
11maturation of SSU-rRNA (GO:0030490)4.25193461
12pseudouridine synthesis (GO:0001522)4.24393801
13translational termination (GO:0006415)4.21745976
14ribosomal small subunit biogenesis (GO:0042274)4.08841760
15establishment of integrated proviral latency (GO:0075713)4.03908612
16tRNA aminoacylation for protein translation (GO:0006418)4.00478662
17ribosomal large subunit biogenesis (GO:0042273)3.97444576
18CENP-A containing nucleosome assembly (GO:0034080)3.97245748
19DNA ligation (GO:0006266)3.95573461
20telomere maintenance via telomere lengthening (GO:0010833)3.95242991
21mitotic recombination (GO:0006312)3.94939802
22tRNA aminoacylation (GO:0043039)3.93019048
23amino acid activation (GO:0043038)3.93019048
24translational elongation (GO:0006414)3.90598226
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.82910056
26chromatin remodeling at centromere (GO:0031055)3.82446201
27deoxyribonucleotide biosynthetic process (GO:0009263)3.82224860
28termination of RNA polymerase III transcription (GO:0006386)3.81596822
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.81596822
302-deoxyribonucleotide biosynthetic process (GO:0009265)3.81539264
31deoxyribose phosphate biosynthetic process (GO:0046385)3.81539264
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.81106789
33L-serine metabolic process (GO:0006563)3.76178508
34cotranslational protein targeting to membrane (GO:0006613)3.72170853
35purine nucleobase biosynthetic process (GO:0009113)3.71846711
36formation of translation preinitiation complex (GO:0001731)3.71768664
37nucleobase biosynthetic process (GO:0046112)3.69303027
38DNA replication checkpoint (GO:0000076)3.68913353
39protein targeting to ER (GO:0045047)3.68779402
40ribonucleoprotein complex biogenesis (GO:0022613)3.67001656
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.64699512
42cullin deneddylation (GO:0010388)3.61183737
43DNA unwinding involved in DNA replication (GO:0006268)3.60811317
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58798304
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.56920720
46regulation of mitochondrial translation (GO:0070129)3.55912745
47protein deneddylation (GO:0000338)3.55679459
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.55669608
49translational initiation (GO:0006413)3.55403865
50nucleotide-excision repair, DNA gap filling (GO:0006297)3.55256214
51spliceosomal snRNP assembly (GO:0000387)3.55012015
52transcription-coupled nucleotide-excision repair (GO:0006283)3.53154506
53protein localization to endoplasmic reticulum (GO:0070972)3.51621424
54folic acid-containing compound biosynthetic process (GO:0009396)3.48402825
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48060877
56protein complex biogenesis (GO:0070271)3.48023190
57ribosome assembly (GO:0042255)3.47555233
58mitochondrial respiratory chain complex assembly (GO:0033108)3.47102616
59positive regulation of ligase activity (GO:0051351)3.46871689
60pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.46627751
61establishment of protein localization to endoplasmic reticulum (GO:0072599)3.46408570
62ribosome biogenesis (GO:0042254)3.44447612
63negative regulation of ligase activity (GO:0051352)3.43787164
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43787164
65translation (GO:0006412)3.43262350
66rRNA modification (GO:0000154)3.43049724
67mitotic metaphase plate congression (GO:0007080)3.42252520
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.41717823
69respiratory chain complex IV assembly (GO:0008535)3.41455136
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40619859
71mitochondrial respiratory chain complex I assembly (GO:0032981)3.40619859
72NADH dehydrogenase complex assembly (GO:0010257)3.40619859
73rRNA processing (GO:0006364)3.39824471
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.39292392
75DNA replication-independent nucleosome assembly (GO:0006336)3.37096393
76DNA replication-independent nucleosome organization (GO:0034724)3.37096393
77cellular protein complex disassembly (GO:0043624)3.36383679
78mitotic sister chromatid segregation (GO:0000070)3.36247682
79spliceosomal complex assembly (GO:0000245)3.35768164
80viral mRNA export from host cell nucleus (GO:0046784)3.35051159
81cellular component biogenesis (GO:0044085)3.34650813
82regulation of ubiquitin-protein transferase activity (GO:0051438)3.34365903
83viral life cycle (GO:0019058)3.33772565
847-methylguanosine mRNA capping (GO:0006370)3.33307206
85regulation of cellular amino acid metabolic process (GO:0006521)3.33109908
86rRNA metabolic process (GO:0016072)3.28157309
87RNA capping (GO:0036260)3.28091033
887-methylguanosine RNA capping (GO:0009452)3.28091033
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27885294
90DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26736042
91kinetochore assembly (GO:0051382)3.25673187
92mitotic spindle checkpoint (GO:0071174)3.25419857
93deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.24582268
94ATP synthesis coupled proton transport (GO:0015986)3.24546057
95energy coupled proton transport, down electrochemical gradient (GO:0015985)3.24546057
96tRNA methylation (GO:0030488)3.23730613
97sister chromatid segregation (GO:0000819)3.23002081
98signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22597376
99signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22597376
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22597376
101intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.21754008
102signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.21754008
103negative regulation of chromosome segregation (GO:0051985)3.20720382
104negative regulation of mitotic sister chromatid separation (GO:2000816)3.20613726
105negative regulation of sister chromatid segregation (GO:0033046)3.20613726
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20613726
107negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20613726
108negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20613726
109regulation of ligase activity (GO:0051340)3.20216241
110regulation of nuclear cell cycle DNA replication (GO:0033262)3.18720782
111mitotic spindle assembly checkpoint (GO:0007094)3.18636167
112pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.18630957
113G1/S transition of mitotic cell cycle (GO:0000082)3.13929267
114cell cycle G1/S phase transition (GO:0044843)3.13929267
115oxidative phosphorylation (GO:0006119)3.13833487
116kinetochore organization (GO:0051383)3.13600604
117signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13144230
118signal transduction involved in DNA damage checkpoint (GO:0072422)3.13144230
119establishment of viral latency (GO:0019043)3.13090741
120spindle assembly checkpoint (GO:0071173)3.12715517
121histone exchange (GO:0043486)3.11590133
122signal transduction involved in cell cycle checkpoint (GO:0072395)3.11549648
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.11191274
124spindle checkpoint (GO:0031577)3.09853105
125nucleobase-containing small molecule interconversion (GO:0015949)3.09539745
126* tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08651188
127DNA damage response, detection of DNA damage (GO:0042769)3.05738312
128metaphase plate congression (GO:0051310)3.03889817
129protein K11-linked ubiquitination (GO:0070979)3.02010070
130protein targeting to mitochondrion (GO:0006626)3.01206066
131regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.99971874
132metallo-sulfur cluster assembly (GO:0031163)2.97389068
133iron-sulfur cluster assembly (GO:0016226)2.97389068
134* tRNA metabolic process (GO:0006399)2.97285382
135protein neddylation (GO:0045116)2.95517795
136mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95246505
137pteridine-containing compound biosynthetic process (GO:0042559)2.92789218
138establishment of protein localization to mitochondrial membrane (GO:0090151)2.90959761
139peptidyl-histidine modification (GO:0018202)2.90040352
140regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88080816
141regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88080816
142maturation of 5.8S rRNA (GO:0000460)2.87384769
143regulation of mitotic sister chromatid separation (GO:0010965)2.86798786
144regulation of mitotic sister chromatid segregation (GO:0033047)2.86798786
145regulation of sister chromatid segregation (GO:0033045)2.86798786
146IMP biosynthetic process (GO:0006188)2.86335924
147protein localization to kinetochore (GO:0034501)2.85981588
148double-strand break repair via nonhomologous end joining (GO:0006303)2.85638299
149non-recombinational repair (GO:0000726)2.85638299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.63829552
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.69351699
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.34595847
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96633354
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.80935522
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.76469237
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.75308273
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35537103
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.34557609
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.26127558
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.22638864
12MYC_19030024_ChIP-ChIP_MESCs_Mouse3.03543789
13ELF1_17652178_ChIP-ChIP_JURKAT_Human3.03335761
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90154701
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84625005
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83013267
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81812791
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75364230
19* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64210870
20VDR_23849224_ChIP-Seq_CD4+_Human2.62344945
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62043211
22XRN2_22483619_ChIP-Seq_HELA_Human2.48606480
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40866944
24FOXP3_21729870_ChIP-Seq_TREG_Human2.36788700
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36145595
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33230992
27* DCP1A_22483619_ChIP-Seq_HELA_Human2.25366771
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.16951063
29TTF2_22483619_ChIP-Seq_HELA_Human2.16761628
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12422598
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.11856907
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11816978
33GABP_19822575_ChIP-Seq_HepG2_Human2.11362811
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08787954
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00964647
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99717002
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98518963
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94741145
39ELK1_19687146_ChIP-ChIP_HELA_Human1.94700359
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.93853282
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.87317391
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.86697950
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84302159
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83415901
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82799730
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81489664
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76913244
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73234212
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72850100
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70591989
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63329323
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61045170
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.60793646
54CIITA_25753668_ChIP-Seq_RAJI_Human1.57273213
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56011186
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53708665
57AR_21909140_ChIP-Seq_LNCAP_Human1.50642380
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42442867
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41180211
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36465100
61MYC_18940864_ChIP-ChIP_HL60_Human1.36157156
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32215339
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31990107
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27933591
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21836731
66* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21388916
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.19647107
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18743134
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17042606
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.15352916
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14948783
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.12199133
73KDM5A_27292631_Chip-Seq_BREAST_Human1.11537560
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11214264
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10052117
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07966397
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07081309
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04168828
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02831265
80EWS_26573619_Chip-Seq_HEK293_Human0.96673960
81FUS_26573619_Chip-Seq_HEK293_Human0.96557393
82IGF1R_20145208_ChIP-Seq_DFB_Human0.96466570
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95232681
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93300963
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93240977
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91222983
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90413089
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89331317
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87706983
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87131364
91TFEB_21752829_ChIP-Seq_HELA_Human0.85240679
92ZNF274_21170338_ChIP-Seq_K562_Hela0.85172329
93CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84880865
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84445267
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81372574
96SPI1_23547873_ChIP-Seq_NB4_Human0.79834192
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79674759
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79538201
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75945858
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75752749
101TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74615708
102IRF1_19129219_ChIP-ChIP_H3396_Human0.72535195
103VDR_22108803_ChIP-Seq_LS180_Human0.72284876
104KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69916888
105TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69597065
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.69200123
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.67670454
108TP53_22573176_ChIP-Seq_HFKS_Human0.67381951
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.67328190
110CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.65930499
111ELF5_23300383_ChIP-Seq_T47D_Human0.65242208
112GATA4_21415370_ChIP-Seq_HL-1_Mouse0.64206423
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.63383471
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.62827586
115EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.62769699
116MYC_22102868_ChIP-Seq_BL_Human0.61350854
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.60606834
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.59885613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.66179239
2MP0010094_abnormal_chromosome_stability4.03742295
3MP0008058_abnormal_DNA_repair4.00714436
4MP0004957_abnormal_blastocyst_morpholog3.73033988
5MP0003111_abnormal_nucleus_morphology3.46446704
6MP0008057_abnormal_DNA_replication3.41809734
7MP0003077_abnormal_cell_cycle3.28072786
8MP0008007_abnormal_cellular_replicative2.85873138
9MP0006292_abnormal_olfactory_placode2.78207258
10MP0002396_abnormal_hematopoietic_system2.74651488
11MP0008932_abnormal_embryonic_tissue2.74114643
12MP0001986_abnormal_taste_sensitivity2.46570643
13MP0008877_abnormal_DNA_methylation2.41692915
14MP0003123_paternal_imprinting2.36485513
15MP0009379_abnormal_foot_pigmentation2.27715621
16MP0009697_abnormal_copulation1.97146558
17MP0003786_premature_aging1.93070385
18MP0001188_hyperpigmentation1.91753477
19MP0006036_abnormal_mitochondrial_physio1.77994720
20MP0002877_abnormal_melanocyte_morpholog1.72516136
21MP0000490_abnormal_crypts_of1.71252079
22MP0002938_white_spotting1.69803694
23MP0002160_abnormal_reproductive_system1.67164346
24MP0005408_hypopigmentation1.66781293
25MP0003221_abnormal_cardiomyocyte_apopto1.65201448
26MP0005171_absent_coat_pigmentation1.62385311
27MP0003121_genomic_imprinting1.61772754
28MP0002234_abnormal_pharynx_morphology1.60189157
29MP0004808_abnormal_hematopoietic_stem1.58712563
30MP0001661_extended_life_span1.58500575
31MP0004147_increased_porphyrin_level1.46969374
32MP0003315_abnormal_perineum_morphology1.43703038
33MP0006035_abnormal_mitochondrial_morpho1.42827142
34MP0005075_abnormal_melanosome_morpholog1.41884767
35MP0002837_dystrophic_cardiac_calcinosis1.38445171
36MP0000350_abnormal_cell_proliferation1.37696726
37MP0002095_abnormal_skin_pigmentation1.33158705
38MP0005174_abnormal_tail_pigmentation1.32081594
39MP0005253_abnormal_eye_physiology1.31959793
40MP0006054_spinal_hemorrhage1.31818621
41MP0003186_abnormal_redox_activity1.30199941
42MP0004233_abnormal_muscle_weight1.28379418
43MP0005389_reproductive_system_phenotype1.27500974
44MP0002102_abnormal_ear_morphology1.26081927
45MP0003122_maternal_imprinting1.24956276
46MP0003941_abnormal_skin_development1.24070337
47MP0000049_abnormal_middle_ear1.23772756
48MP0000313_abnormal_cell_death1.23322330
49MP0003567_abnormal_fetal_cardiomyocyte1.23293343
50MP0000647_abnormal_sebaceous_gland1.19488420
51MP0000372_irregular_coat_pigmentation1.18520243
52MP0002132_abnormal_respiratory_system1.15838964
53MP0002090_abnormal_vision1.15109879
54MP0002751_abnormal_autonomic_nervous1.15022445
55MP0003763_abnormal_thymus_physiology1.14989886
56MP0001730_embryonic_growth_arrest1.13781814
57MP0009333_abnormal_splenocyte_physiolog1.11188317
58MP0005645_abnormal_hypothalamus_physiol1.11073532
59MP0001984_abnormal_olfaction1.08986903
60MP0005397_hematopoietic_system_phenotyp1.08602387
61MP0001545_abnormal_hematopoietic_system1.08602387
62MP0000015_abnormal_ear_pigmentation1.08222564
63MP0003718_maternal_effect1.07427509
64MP0008995_early_reproductive_senescence1.07024689
65MP0002210_abnormal_sex_determination1.06483502
66MP0001919_abnormal_reproductive_system1.04524040
67MP0001697_abnormal_embryo_size1.04507963
68MP0002019_abnormal_tumor_incidence1.02639782
69MP0002638_abnormal_pupillary_reflex1.01971292
70MP0002269_muscular_atrophy1.01274771
71MP0002080_prenatal_lethality1.01266074
72MP0005379_endocrine/exocrine_gland_phen0.98840743
73MP0000358_abnormal_cell_content/0.98232163
74MP0003937_abnormal_limbs/digits/tail_de0.97540447
75MP0001764_abnormal_homeostasis0.97499593
76MP0004215_abnormal_myocardial_fiber0.97448787
77MP0001929_abnormal_gametogenesis0.96253558
78MP0001243_abnormal_dermal_layer0.96211196
79MP0001529_abnormal_vocalization0.96052500
80MP0003656_abnormal_erythrocyte_physiolo0.95845382
81MP0000678_abnormal_parathyroid_gland0.95806378
82MP0001727_abnormal_embryo_implantation0.94612206
83MP0004133_heterotaxia0.93885728
84MP0008789_abnormal_olfactory_epithelium0.93635957
85MP0001905_abnormal_dopamine_level0.92196546
86MP0002163_abnormal_gland_morphology0.90242888
87MP0000703_abnormal_thymus_morphology0.87405450
88MP0004145_abnormal_muscle_electrophysio0.86909905
89MP0004197_abnormal_fetal_growth/weight/0.86160885
90MP0001145_abnormal_male_reproductive0.85749043
91MP0000681_abnormal_thyroid_gland0.85377402
92MP0005084_abnormal_gallbladder_morpholo0.82783841
93MP0000566_synostosis0.82152663
94MP0003119_abnormal_digestive_system0.81756425
95MP0001672_abnormal_embryogenesis/_devel0.81317364
96MP0005380_embryogenesis_phenotype0.81317364
97MP0002084_abnormal_developmental_patter0.80632005
98MP0002398_abnormal_bone_marrow0.80235873
99MP0003787_abnormal_imprinting0.79643792
100MP0010030_abnormal_orbit_morphology0.78949334
101MP0001293_anophthalmia0.78022210
102MP0006276_abnormal_autonomic_nervous0.77427320
103MP0002085_abnormal_embryonic_tissue0.76944827
104MP0003136_yellow_coat_color0.76496739
105MP0001119_abnormal_female_reproductive0.76068687
106MP0000631_abnormal_neuroendocrine_gland0.75799169
107MP0002722_abnormal_immune_system0.74692629
108MP0000653_abnormal_sex_gland0.73870490
109MP0003943_abnormal_hepatobiliary_system0.73295185
110MP0000749_muscle_degeneration0.72611548
111MP0002736_abnormal_nociception_after0.72502243
112MP0003942_abnormal_urinary_system0.70869660
113MP0000689_abnormal_spleen_morphology0.70409224
114MP0002277_abnormal_respiratory_mucosa0.70399986
115MP0005409_darkened_coat_color0.70258069
116MP0005384_cellular_phenotype0.69537421
117MP0005391_vision/eye_phenotype0.69262074
118MP0003984_embryonic_growth_retardation0.68626884
119MP0010307_abnormal_tumor_latency0.67845316
120MP0005332_abnormal_amino_acid0.67790093
121MP0001186_pigmentation_phenotype0.67437106
122MP0002075_abnormal_coat/hair_pigmentati0.67150423
123MP0003879_abnormal_hair_cell0.66982783
124MP0005083_abnormal_biliary_tract0.66754192
125MP0000569_abnormal_digit_pigmentation0.66450680
126MP0001853_heart_inflammation0.65927899
127MP0005330_cardiomyopathy0.65755538
128MP0010234_abnormal_vibrissa_follicle0.64434101
129MP0006072_abnormal_retinal_apoptosis0.63897280
130MP0002177_abnormal_outer_ear0.63320540
131MP0002088_abnormal_embryonic_growth/wei0.62797545
132MP0003890_abnormal_embryonic-extraembry0.62511758
133MP0003806_abnormal_nucleotide_metabolis0.62446882
134MP0009672_abnormal_birth_weight0.58443226
135MP0001299_abnormal_eye_distance/0.56018982
136MP0003137_abnormal_impulse_conducting0.53210757
137MP0003698_abnormal_male_reproductive0.52480209
138MP0005367_renal/urinary_system_phenotyp0.52465871
139MP0000516_abnormal_urinary_system0.52465871
140MP0003385_abnormal_body_wall0.51933450
141MP0000427_abnormal_hair_cycle0.51275019

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.30449431
2Abnormal number of erythroid precursors (HP:0012131)5.22351455
3Birth length less than 3rd percentile (HP:0003561)4.49213064
4Aplastic anemia (HP:0001915)4.21013931
5Acute necrotizing encephalopathy (HP:0006965)4.09392319
6Reticulocytopenia (HP:0001896)4.07690756
7Decreased activity of mitochondrial respiratory chain (HP:0008972)3.90950129
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.90950129
9Mitochondrial inheritance (HP:0001427)3.83427082
10Abnormal mitochondria in muscle tissue (HP:0008316)3.74764567
11Increased serum pyruvate (HP:0003542)3.73866786
12Hepatocellular necrosis (HP:0001404)3.68565842
13Abnormality of glycolysis (HP:0004366)3.63736748
14Increased CSF lactate (HP:0002490)3.63548776
15Oral leukoplakia (HP:0002745)3.56961599
16Increased serum lactate (HP:0002151)3.35343476
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.27446381
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.25320505
19Cortical dysplasia (HP:0002539)3.24387723
20Progressive macrocephaly (HP:0004481)3.21798763
21Hepatic necrosis (HP:0002605)3.17120834
22Cerebral edema (HP:0002181)3.16720980
23Pallor (HP:0000980)3.16682528
24Microvesicular hepatic steatosis (HP:0001414)3.15114827
25Increased hepatocellular lipid droplets (HP:0006565)3.13596616
26Abnormality of the heme biosynthetic pathway (HP:0010472)3.04542861
27Acute encephalopathy (HP:0006846)3.00479659
283-Methylglutaconic aciduria (HP:0003535)2.97797604
29Lipid accumulation in hepatocytes (HP:0006561)2.97292056
30Macrocytic anemia (HP:0001972)2.97116422
31Type I transferrin isoform profile (HP:0003642)2.94108836
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90083705
33Exercise intolerance (HP:0003546)2.87119406
34Microretrognathia (HP:0000308)2.77104221
35Colon cancer (HP:0003003)2.69363345
36Chromsome breakage (HP:0040012)2.68665237
37Rough bone trabeculation (HP:0100670)2.66317071
38Lactic acidosis (HP:0003128)2.64647060
39Respiratory difficulties (HP:0002880)2.63522756
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60318631
41Abnormality of alanine metabolism (HP:0010916)2.60318631
42Hyperalaninemia (HP:0003348)2.60318631
43Premature graying of hair (HP:0002216)2.60022015
44Breast hypoplasia (HP:0003187)2.59400987
45Abnormality of the pons (HP:0007361)2.56607718
46Pancreatic fibrosis (HP:0100732)2.55285366
47Upper limb muscle weakness (HP:0003484)2.53951159
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53857300
4911 pairs of ribs (HP:0000878)2.48782727
50Hyperglycinemia (HP:0002154)2.48114690
51Postnatal microcephaly (HP:0005484)2.45586098
52Abnormality of methionine metabolism (HP:0010901)2.44450066
53Exertional dyspnea (HP:0002875)2.43788862
54Pancytopenia (HP:0001876)2.41626389
55Hypoplasia of the pons (HP:0012110)2.41500674
56Abnormality of the preputium (HP:0100587)2.38869369
57Meckel diverticulum (HP:0002245)2.37326116
58True hermaphroditism (HP:0010459)2.37072743
59Cholecystitis (HP:0001082)2.34568248
60Abnormal gallbladder physiology (HP:0012438)2.34568248
61IgM deficiency (HP:0002850)2.33038765
62Pancreatic cysts (HP:0001737)2.30508852
63Severe visual impairment (HP:0001141)2.27854321
64Abnormality of the ileum (HP:0001549)2.26477662
65Patellar aplasia (HP:0006443)2.26402942
66Cutaneous melanoma (HP:0012056)2.24236760
67Abnormal lung lobation (HP:0002101)2.21590563
68Renal Fanconi syndrome (HP:0001994)2.21265635
69Renal cortical cysts (HP:0000803)2.20275950
70Leukodystrophy (HP:0002415)2.19774859
71Aplasia/Hypoplasia of the patella (HP:0006498)2.19743223
72Respiratory failure (HP:0002878)2.18555113
73Medulloblastoma (HP:0002885)2.17811577
74Type 2 muscle fiber atrophy (HP:0003554)2.17603133
75Selective tooth agenesis (HP:0001592)2.15805506
76Reduced antithrombin III activity (HP:0001976)2.15684222
77Lethargy (HP:0001254)2.15251697
78Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13764179
79Abnormality of chromosome stability (HP:0003220)2.13386330
80Muscle fiber atrophy (HP:0100295)2.12848204
81Progressive microcephaly (HP:0000253)2.11909995
82Hypothermia (HP:0002045)2.11079547
83Palpitations (HP:0001962)2.09569818
84Increased intramyocellular lipid droplets (HP:0012240)2.08969233
85Optic disc pallor (HP:0000543)2.08537629
86Myelodysplasia (HP:0002863)2.06232959
87Bone marrow hypocellularity (HP:0005528)2.03085146
88Hypoglycemic coma (HP:0001325)2.02453124
89Multiple enchondromatosis (HP:0005701)2.02343065
90Abnormality of serum amino acid levels (HP:0003112)1.99962082
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99421624
92Abnormal protein N-linked glycosylation (HP:0012347)1.99421624
93Abnormal protein glycosylation (HP:0012346)1.99421624
94Abnormal glycosylation (HP:0012345)1.99421624
95CNS demyelination (HP:0007305)1.98786549
96Supernumerary spleens (HP:0009799)1.98674488
97Prominent metopic ridge (HP:0005487)1.98603609
98Myoglobinuria (HP:0002913)1.97727185
99Cellular immunodeficiency (HP:0005374)1.97688580
100Asplenia (HP:0001746)1.96966252
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.96584623
102Neoplasm of the pancreas (HP:0002894)1.96361787
103Degeneration of anterior horn cells (HP:0002398)1.96022742
104Abnormality of the anterior horn cell (HP:0006802)1.96022742
105Abnormal number of incisors (HP:0011064)1.94998712
106Neoplasm of the adrenal gland (HP:0100631)1.94051529
107Exercise-induced muscle cramps (HP:0003710)1.93722296
108Acute lymphatic leukemia (HP:0006721)1.93421531
109Irregular epiphyses (HP:0010582)1.91477265
110Absent thumb (HP:0009777)1.91315825
111Progressive muscle weakness (HP:0003323)1.90627923
112Nephroblastoma (Wilms tumor) (HP:0002667)1.90586656
113Hypokinesia (HP:0002375)1.89867910
114Abnormal trabecular bone morphology (HP:0100671)1.88995359
115Abnormality of placental membranes (HP:0011409)1.88518074
116Amniotic constriction ring (HP:0009775)1.88518074
117Sloping forehead (HP:0000340)1.88163068
118Atrophy/Degeneration involving motor neurons (HP:0007373)1.87956001
119Agnosia (HP:0010524)1.87696892
120Abnormality of the metopic suture (HP:0005556)1.86471174
121Emotional lability (HP:0000712)1.85448330
122Cerebral hypomyelination (HP:0006808)1.84913010
123Sparse eyelashes (HP:0000653)1.84407022
124Unsteady gait (HP:0002317)1.84164743
125Generalized aminoaciduria (HP:0002909)1.84082332
126Triphalangeal thumb (HP:0001199)1.81957018
127Small intestinal stenosis (HP:0012848)1.81749039
128Duodenal stenosis (HP:0100867)1.81749039
129Spastic paraparesis (HP:0002313)1.81042506
130Aplasia/Hypoplasia of the spleen (HP:0010451)1.80696023
131Redundant skin (HP:0001582)1.80270334
132Aplasia/hypoplasia of the uterus (HP:0008684)1.80250004
133Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79327356
134Medial flaring of the eyebrow (HP:0010747)1.78344040
135Increased muscle lipid content (HP:0009058)1.76291751
136Embryonal renal neoplasm (HP:0011794)1.76155908
137Neonatal respiratory distress (HP:0002643)1.76013662
138Abnormality of glycine metabolism (HP:0010895)1.75063476
139Abnormality of serine family amino acid metabolism (HP:0010894)1.75063476
140Anencephaly (HP:0002323)1.75025245
141Facial cleft (HP:0002006)1.74245251
142Congenital primary aphakia (HP:0007707)1.71968025
143Nephrogenic diabetes insipidus (HP:0009806)1.64158383
144CNS hypomyelination (HP:0003429)1.63472635
145Muscular hypotonia of the trunk (HP:0008936)1.63440724
146Poor head control (HP:0002421)1.62964240
147Unilateral renal agenesis (HP:0000122)1.62209882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.74245830
2STK163.65516284
3BUB13.56306917
4ACVR1B3.24194413
5TRIM282.91822211
6CDC72.90856955
7NME22.90111161
8SRPK12.85325407
9VRK12.73811830
10EIF2AK12.57388241
11PLK42.48642290
12BRSK22.46851299
13VRK22.40443437
14BCR2.39522353
15BCKDK2.19982324
16MKNK12.12485990
17CCNB12.06989502
18NME12.04319648
19EIF2AK31.94944446
20ZAK1.92769176
21TLK11.86234449
22NEK11.85508892
23TSSK61.81757664
24MKNK21.78918818
25CDK191.78571249
26PIM21.71386615
27CSNK1G31.59424722
28MAP4K21.55521550
29BRSK11.49610956
30PLK11.48501484
31TGFBR11.42887466
32DYRK31.42071650
33BRAF1.40003166
34CASK1.38873234
35CSNK1A1L1.38470170
36CSNK1G11.35794976
37PLK31.32303677
38FLT31.31858186
39PASK1.31488122
40ARAF1.30020499
41NEK21.27955884
42CSNK1G21.20431523
43ATR1.18433859
44RPS6KA41.17839917
45CDK71.17673421
46PDK21.17574060
47KDR1.17107312
48CDK81.16882728
49AURKB1.16016750
50TTK1.14271380
51FRK1.13924242
52BMPR21.09906255
53AURKA1.09146641
54CAMKK21.04496890
55NUAK11.03683011
56EIF2AK21.03657962
57RPS6KB21.03174809
58TNIK1.01364465
59MUSK1.00579907
60TEC0.99937683
61MAP3K40.96712732
62WNK30.93828369
63CLK10.92662052
64TESK20.90244822
65BMPR1B0.89719096
66CHEK20.84817117
67MAP3K120.80492225
68MAP2K70.78630894
69IRAK40.78501192
70SIK30.78221544
71SCYL20.78077562
72TNK20.76563390
73CSNK2A10.76279753
74YES10.76195810
75MAP2K30.74803926
76DAPK10.74738430
77MYLK0.74033303
78KIT0.73038314
79CSNK2A20.67018273
80MAP2K60.66438472
81BLK0.64396125
82ADRBK20.64132864
83PLK20.61367209
84MAPKAPK50.59838385
85STK30.59253315
86TIE10.59207410
87TESK10.57861995
88RPS6KA50.57791694
89CDK140.56235716
90ERBB40.56095211
91LATS10.55731183
92CHEK10.54031522
93IRAK30.53952896
94ALK0.51330735
95PAK40.50103642
96PIK3CG0.47952717
97TXK0.46960558
98CDK180.44394324
99PIM10.42397093
100PINK10.42170664
101BTK0.41196239
102MST40.40125780
103STK40.40108823
104GRK10.40057949
105CDK40.39540233
106ATM0.39045424
107MAPKAPK30.37714411
108STK100.36130078
109CDK20.35931050
110PRKCI0.35634378
111ILK0.35573560
112PBK0.34836595
113MAP3K80.34685495
114CDK150.34560074
115MAPK130.34554551
116CDK11A0.34298626
117ERBB30.34109775
118RAF10.34027852
119CDK30.32757546
120MINK10.32355905
121WNK40.32202090
122DYRK20.31647843
123EPHA20.30529967
124STK38L0.29965310
125CAMK10.29598636
126LIMK10.29469968
127TAOK20.27576600
128PAK10.26881263
129CDK10.26709081
130AKT30.26356734
131AKT20.24320012

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.02521497
2Ribosome_Homo sapiens_hsa030104.42645232
3Mismatch repair_Homo sapiens_hsa034304.23325728
4Proteasome_Homo sapiens_hsa030504.15144829
5RNA polymerase_Homo sapiens_hsa030203.64313735
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12442600
7Base excision repair_Homo sapiens_hsa034102.99323798
8Homologous recombination_Homo sapiens_hsa034402.98159807
9Spliceosome_Homo sapiens_hsa030402.89692887
10Nucleotide excision repair_Homo sapiens_hsa034202.87515387
11Pyrimidine metabolism_Homo sapiens_hsa002402.83678742
12RNA transport_Homo sapiens_hsa030132.35550170
13Parkinsons disease_Homo sapiens_hsa050122.30527683
14Oxidative phosphorylation_Homo sapiens_hsa001902.28006051
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08937737
16Cell cycle_Homo sapiens_hsa041102.08733875
17Fanconi anemia pathway_Homo sapiens_hsa034601.98684829
18RNA degradation_Homo sapiens_hsa030181.96017169
19Non-homologous end-joining_Homo sapiens_hsa034501.94524510
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92889827
21Protein export_Homo sapiens_hsa030601.92076148
22Huntingtons disease_Homo sapiens_hsa050161.91443119
23One carbon pool by folate_Homo sapiens_hsa006701.90301466
24Basal transcription factors_Homo sapiens_hsa030221.87721823
25Propanoate metabolism_Homo sapiens_hsa006401.80216153
26Fatty acid elongation_Homo sapiens_hsa000621.79159588
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71944999
28Purine metabolism_Homo sapiens_hsa002301.71243248
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65406283
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49587171
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48089034
32Pyruvate metabolism_Homo sapiens_hsa006201.44963568
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44197937
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39529235
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34484714
36Alzheimers disease_Homo sapiens_hsa050101.34274207
37Folate biosynthesis_Homo sapiens_hsa007901.23557665
38Steroid biosynthesis_Homo sapiens_hsa001001.20690704
39Butanoate metabolism_Homo sapiens_hsa006501.18336835
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10943927
41p53 signaling pathway_Homo sapiens_hsa041151.07753534
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04867483
43Vitamin B6 metabolism_Homo sapiens_hsa007501.04696397
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95424194
45mRNA surveillance pathway_Homo sapiens_hsa030150.93832720
46Epstein-Barr virus infection_Homo sapiens_hsa051690.93309395
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84738537
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83862931
49Sulfur relay system_Homo sapiens_hsa041220.80469967
50Peroxisome_Homo sapiens_hsa041460.79771883
51Fatty acid metabolism_Homo sapiens_hsa012120.77753134
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76904210
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76569340
54Sulfur metabolism_Homo sapiens_hsa009200.76306258
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74590478
56Cardiac muscle contraction_Homo sapiens_hsa042600.73438291
57N-Glycan biosynthesis_Homo sapiens_hsa005100.72615907
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71997969
59Systemic lupus erythematosus_Homo sapiens_hsa053220.71250287
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.70700700
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69566766
62Oocyte meiosis_Homo sapiens_hsa041140.67031049
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64474507
64Herpes simplex infection_Homo sapiens_hsa051680.62314294
65Alcoholism_Homo sapiens_hsa050340.56408776
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55988645
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54580909
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52617338
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48089552
70Metabolic pathways_Homo sapiens_hsa011000.45058013
71Antigen processing and presentation_Homo sapiens_hsa046120.42978110
72Phototransduction_Homo sapiens_hsa047440.42496000
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41332458
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.39610330
75Thyroid cancer_Homo sapiens_hsa052160.38986782
76Primary immunodeficiency_Homo sapiens_hsa053400.38129763
77Pentose phosphate pathway_Homo sapiens_hsa000300.37881420
78HTLV-I infection_Homo sapiens_hsa051660.37363891
79Glutathione metabolism_Homo sapiens_hsa004800.36696426
80beta-Alanine metabolism_Homo sapiens_hsa004100.34174332
81Galactose metabolism_Homo sapiens_hsa000520.33090978
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32279786
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30994045
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.30881009
85Viral carcinogenesis_Homo sapiens_hsa052030.29981629
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.27069139
87Biosynthesis of amino acids_Homo sapiens_hsa012300.26546198
88Hematopoietic cell lineage_Homo sapiens_hsa046400.25791379
89Arachidonic acid metabolism_Homo sapiens_hsa005900.25092739
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24268008
91Vibrio cholerae infection_Homo sapiens_hsa051100.21349650
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20806584
93Fructose and mannose metabolism_Homo sapiens_hsa000510.20090151
94Legionellosis_Homo sapiens_hsa051340.19894516
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14802072
96Measles_Homo sapiens_hsa051620.13408900
97Melanoma_Homo sapiens_hsa052180.11571079
98Carbon metabolism_Homo sapiens_hsa012000.11352051
99Taste transduction_Homo sapiens_hsa047420.10810001
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10438787
101Nicotine addiction_Homo sapiens_hsa050330.09535449
102Fatty acid degradation_Homo sapiens_hsa000710.08348893
103Hepatitis B_Homo sapiens_hsa051610.07654104
104Regulation of autophagy_Homo sapiens_hsa041400.07534533
105Wnt signaling pathway_Homo sapiens_hsa043100.06478820
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.06460184
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06068119
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05799270
109Shigellosis_Homo sapiens_hsa051310.05758343
110Basal cell carcinoma_Homo sapiens_hsa052170.05495537
111Collecting duct acid secretion_Homo sapiens_hsa049660.04177568
112Tryptophan metabolism_Homo sapiens_hsa003800.03977681
113Apoptosis_Homo sapiens_hsa042100.03598638
114Circadian rhythm_Homo sapiens_hsa047100.02502144
115Olfactory transduction_Homo sapiens_hsa047400.02007887
116Allograft rejection_Homo sapiens_hsa053300.01465886
117Serotonergic synapse_Homo sapiens_hsa047260.01100010
118Nitrogen metabolism_Homo sapiens_hsa009100.00861271
119Pathways in cancer_Homo sapiens_hsa052000.00791704
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.00775661
121Maturity onset diabetes of the young_Homo sapiens_hsa04950-0.0533149
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0428830
123Synaptic vesicle cycle_Homo sapiens_hsa04721-0.0375223
124Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0359940
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0323605
126Selenocompound metabolism_Homo sapiens_hsa00450-0.0299924
127Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0194088
128Arginine and proline metabolism_Homo sapiens_hsa00330-0.0030425
129Colorectal cancer_Homo sapiens_hsa05210-0.0005835
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0004217

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