TSEN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication initiation (GO:0006270)4.72184637
2telomere maintenance via semi-conservative replication (GO:0032201)4.55793114
3DNA deamination (GO:0045006)4.38953903
4nucleobase biosynthetic process (GO:0046112)4.35309844
5purine nucleobase biosynthetic process (GO:0009113)4.26335851
6proteasome assembly (GO:0043248)4.23204995
7termination of RNA polymerase III transcription (GO:0006386)4.18647352
8transcription elongation from RNA polymerase III promoter (GO:0006385)4.18647352
9DNA strand elongation involved in DNA replication (GO:0006271)4.08043030
10DNA replication checkpoint (GO:0000076)3.97892373
11telomere maintenance via telomere lengthening (GO:0010833)3.97698770
12telomere maintenance via recombination (GO:0000722)3.97148996
13behavioral response to nicotine (GO:0035095)3.96879087
14DNA strand elongation (GO:0022616)3.93399251
15nucleotide-excision repair, DNA gap filling (GO:0006297)3.91799627
16CENP-A containing nucleosome assembly (GO:0034080)3.87088310
17pseudouridine synthesis (GO:0001522)3.83643819
18chromatin remodeling at centromere (GO:0031055)3.79765797
19ribosome biogenesis (GO:0042254)3.75298579
20DNA double-strand break processing (GO:0000729)3.75246744
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.72775942
22regulation of nuclear cell cycle DNA replication (GO:0033262)3.65630340
23ribosomal small subunit assembly (GO:0000028)3.62003909
24kinetochore assembly (GO:0051382)3.60754973
25polyketide metabolic process (GO:0030638)3.59938423
26doxorubicin metabolic process (GO:0044598)3.59938423
27daunorubicin metabolic process (GO:0044597)3.59938423
28transcription-coupled nucleotide-excision repair (GO:0006283)3.59129525
29mitotic recombination (GO:0006312)3.58940820
30spliceosomal snRNP assembly (GO:0000387)3.54482468
31IMP biosynthetic process (GO:0006188)3.53705053
32mitotic metaphase plate congression (GO:0007080)3.53359187
33maturation of 5.8S rRNA (GO:0000460)3.52115084
34transcription elongation from RNA polymerase I promoter (GO:0006362)3.48584850
35L-fucose catabolic process (GO:0042355)3.47685792
36fucose catabolic process (GO:0019317)3.47685792
37L-fucose metabolic process (GO:0042354)3.47685792
38ribonucleoprotein complex biogenesis (GO:0022613)3.42471473
39cullin deneddylation (GO:0010388)3.39900753
40maturation of SSU-rRNA (GO:0030490)3.37163477
41protein complex biogenesis (GO:0070271)3.36736828
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35751490
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.35751490
44NADH dehydrogenase complex assembly (GO:0010257)3.35751490
45kinetochore organization (GO:0051383)3.34325371
46RNA capping (GO:0036260)3.32870616
477-methylguanosine RNA capping (GO:0009452)3.32870616
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.32248086
49intra-S DNA damage checkpoint (GO:0031573)3.30048386
50tRNA methylation (GO:0030488)3.29564893
51termination of RNA polymerase I transcription (GO:0006363)3.27228407
52DNA ligation (GO:0006266)3.26949871
53pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.26809561
54ribosomal large subunit biogenesis (GO:0042273)3.26772415
55metaphase plate congression (GO:0051310)3.24604698
56somatic hypermutation of immunoglobulin genes (GO:0016446)3.24555893
57somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24555893
58mitochondrial respiratory chain complex assembly (GO:0033108)3.24252553
59protein deneddylation (GO:0000338)3.24058722
60piRNA metabolic process (GO:0034587)3.24051551
61guanosine-containing compound biosynthetic process (GO:1901070)3.23674596
627-methylguanosine mRNA capping (GO:0006370)3.23506800
63DNA replication-independent nucleosome assembly (GO:0006336)3.22049617
64DNA replication-independent nucleosome organization (GO:0034724)3.22049617
65GMP metabolic process (GO:0046037)3.22010278
66viral mRNA export from host cell nucleus (GO:0046784)3.18645754
67synapsis (GO:0007129)3.18257301
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16005127
69transcription from RNA polymerase I promoter (GO:0006360)3.13860437
70indole-containing compound catabolic process (GO:0042436)3.13796191
71indolalkylamine catabolic process (GO:0046218)3.13796191
72tryptophan catabolic process (GO:0006569)3.13796191
73kynurenine metabolic process (GO:0070189)3.13024961
74rRNA processing (GO:0006364)3.12048006
75* RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11960392
76* tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11960392
77establishment of integrated proviral latency (GO:0075713)3.11899874
78indolalkylamine metabolic process (GO:0006586)3.11371668
79recombinational repair (GO:0000725)3.10800876
80double-strand break repair via homologous recombination (GO:0000724)3.09576219
81rRNA catabolic process (GO:0016075)3.07860712
82preassembly of GPI anchor in ER membrane (GO:0016254)3.06987570
83mitochondrial RNA metabolic process (GO:0000959)3.06463418
84histone H2A acetylation (GO:0043968)3.06438739
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06425858
86spliceosomal complex assembly (GO:0000245)3.05482057
87mismatch repair (GO:0006298)3.04522473
88pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.04263924
89reciprocal DNA recombination (GO:0035825)3.04051516
90reciprocal meiotic recombination (GO:0007131)3.04051516
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03911863
92rRNA metabolic process (GO:0016072)3.03375142
93tryptophan metabolic process (GO:0006568)3.02418740
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01218400
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00040184
96regulation of double-strand break repair via homologous recombination (GO:0010569)2.98106307
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97297166
98ubiquinone biosynthetic process (GO:0006744)2.97254773
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97107443
100rRNA modification (GO:0000154)2.96823733
101meiotic chromosome segregation (GO:0045132)2.96529634
102cellular component biogenesis (GO:0044085)2.95829532
103regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.95600374
104regulation of mitotic spindle checkpoint (GO:1903504)2.95600374
105centriole replication (GO:0007099)2.95290968
106GTP biosynthetic process (GO:0006183)2.93843748
107ubiquinone metabolic process (GO:0006743)2.93676361
108mannosylation (GO:0097502)2.93334866
109CTP biosynthetic process (GO:0006241)2.92652258
110CTP metabolic process (GO:0046036)2.92652258
111regulation of centriole replication (GO:0046599)2.92561038
112DNA-dependent DNA replication (GO:0006261)2.92220304
113DNA synthesis involved in DNA repair (GO:0000731)2.91506651
114nucleotide-excision repair (GO:0006289)2.90403490
115negative regulation of DNA-dependent DNA replication (GO:2000104)2.90193509
116histone exchange (GO:0043486)2.89965849
117DNA damage response, detection of DNA damage (GO:0042769)2.89734548
118* tRNA processing (GO:0008033)2.89291915
119detection of light stimulus involved in visual perception (GO:0050908)2.88435282
120detection of light stimulus involved in sensory perception (GO:0050962)2.88435282
121tRNA modification (GO:0006400)2.86783766
122regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86591105
123telomere organization (GO:0032200)2.86262456
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85873662
125amino acid salvage (GO:0043102)2.85477563
126L-methionine salvage (GO:0071267)2.85477563
127L-methionine biosynthetic process (GO:0071265)2.85477563
128telomere maintenance (GO:0000723)2.85321910
129pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.85194939
130respiratory chain complex IV assembly (GO:0008535)2.84923519
131water-soluble vitamin biosynthetic process (GO:0042364)2.84857993
132cytochrome complex assembly (GO:0017004)2.84087233
133peptidyl-histidine modification (GO:0018202)2.83800391
134UTP biosynthetic process (GO:0006228)2.83566359
135negative regulation of ligase activity (GO:0051352)2.83161839
136negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83161839
137formation of translation preinitiation complex (GO:0001731)2.83137403
138detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83065905
139nonmotile primary cilium assembly (GO:0035058)2.82693704
140transcription from RNA polymerase III promoter (GO:0006383)2.82502581
141DNA-templated transcription, termination (GO:0006353)2.82079690
142deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.81824501
143DNA-templated transcription, elongation (GO:0006354)2.81643996
144replication fork processing (GO:0031297)2.80346036
145* ncRNA processing (GO:0034470)2.80341037
146transcription initiation from RNA polymerase I promoter (GO:0006361)2.79869304
147protein K6-linked ubiquitination (GO:0085020)2.79437737
148DNA methylation involved in gamete generation (GO:0043046)2.77218986
149DNA catabolic process, exonucleolytic (GO:0000738)2.75881090
150regulation of cilium movement (GO:0003352)2.70483148
151protein-cofactor linkage (GO:0018065)2.68329813
152male meiosis I (GO:0007141)2.68183117
153response to pheromone (GO:0019236)2.68159580
154protein polyglutamylation (GO:0018095)2.64273291
155branched-chain amino acid catabolic process (GO:0009083)2.61613055
156neural tube formation (GO:0001841)2.61333306
157methionine biosynthetic process (GO:0009086)2.56654463
158photoreceptor cell maintenance (GO:0045494)2.55538286
159regulation of meiosis I (GO:0060631)2.54568076
160ncRNA catabolic process (GO:0034661)2.53815038
161behavioral response to ethanol (GO:0048149)2.52514158
162cellular ketone body metabolic process (GO:0046950)2.52321501
163epithelial cilium movement (GO:0003351)2.51280396
164establishment of protein localization to mitochondrial membrane (GO:0090151)2.49425286
165histone mRNA metabolic process (GO:0008334)2.49321518
166intraciliary transport (GO:0042073)2.48344148
167transcription from mitochondrial promoter (GO:0006390)2.48320099
168regulation of mitochondrial translation (GO:0070129)2.47293544
169cell wall macromolecule catabolic process (GO:0016998)2.46973583
170axoneme assembly (GO:0035082)2.46857709
171postreplication repair (GO:0006301)2.45504145
172epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45056707
173resolution of meiotic recombination intermediates (GO:0000712)2.44831048
174cilium organization (GO:0044782)2.44098922
175G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43494936
176* tRNA metabolic process (GO:0006399)2.41037275
177S-adenosylmethionine metabolic process (GO:0046500)2.41010132
178aspartate family amino acid catabolic process (GO:0009068)2.40340815
179cell wall macromolecule metabolic process (GO:0044036)2.39444766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.05005773
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.54349466
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.10489332
4ZNF274_21170338_ChIP-Seq_K562_Hela3.75646082
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.60135613
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.51829894
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.41215237
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.39491097
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.35298027
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13490580
11VDR_22108803_ChIP-Seq_LS180_Human3.05371399
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.05331166
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86193103
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.84137493
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75567796
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70337493
17* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69067657
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61879237
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61020869
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56597387
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55563022
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52674500
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.39757499
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35450217
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32800934
26* E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28590234
27VDR_23849224_ChIP-Seq_CD4+_Human2.25047540
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22840945
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.14617596
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.12996344
31FOXP3_21729870_ChIP-Seq_TREG_Human2.12007715
32TAF15_26573619_Chip-Seq_HEK293_Human2.11547095
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08347546
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04887576
35E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04019530
36DCP1A_22483619_ChIP-Seq_HELA_Human2.03592564
37ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03273816
38CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03067127
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02183017
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92941375
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91935738
42EZH2_22144423_ChIP-Seq_EOC_Human1.91453517
43* XRN2_22483619_ChIP-Seq_HELA_Human1.89842448
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88657377
45P300_19829295_ChIP-Seq_ESCs_Human1.84241595
46TTF2_22483619_ChIP-Seq_HELA_Human1.82890160
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.81935633
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81472201
49IRF1_19129219_ChIP-ChIP_H3396_Human1.79932754
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78515406
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74117005
52ELK1_19687146_ChIP-ChIP_HELA_Human1.73923693
53* GABP_19822575_ChIP-Seq_HepG2_Human1.71158075
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69501187
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64911931
56ER_23166858_ChIP-Seq_MCF-7_Human1.64887453
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64615569
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62496499
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61279569
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60514303
61TP53_22573176_ChIP-Seq_HFKS_Human1.56863842
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.56051125
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52163113
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.51820584
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.51239971
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49604998
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45380615
68* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41185988
69IGF1R_20145208_ChIP-Seq_DFB_Human1.39769151
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38886447
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37777123
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37143675
73CBP_20019798_ChIP-Seq_JUKART_Human1.37143675
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34881260
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34593175
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34195622
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33560953
78STAT3_23295773_ChIP-Seq_U87_Human1.32094669
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29068452
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29068452
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29068452
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29033252
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28366922
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28225998
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24296290
86CIITA_25753668_ChIP-Seq_RAJI_Human1.21625126
87AR_21909140_ChIP-Seq_LNCAP_Human1.21032673
88* TCF4_23295773_ChIP-Seq_U87_Human1.19533062
89SMAD4_21799915_ChIP-Seq_A2780_Human1.19532544
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19301867
91BCAT_22108803_ChIP-Seq_LS180_Human1.17318490
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17001946
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17001946
94* MYC_18940864_ChIP-ChIP_HL60_Human1.16524022
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16199832
96NANOG_19829295_ChIP-Seq_ESCs_Human1.15314378
97SOX2_19829295_ChIP-Seq_ESCs_Human1.15314378
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15155945
99EWS_26573619_Chip-Seq_HEK293_Human1.14869050
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14762640
101FOXA1_25329375_ChIP-Seq_VCAP_Human1.14762640
102TCF4_22108803_ChIP-Seq_LS180_Human1.14740318
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13776058
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13525561
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.11729580
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.09891927
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09227244
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.08087033
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08072566
110ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07765005
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07115976
112PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07073532
113AR_20517297_ChIP-Seq_VCAP_Human1.07034761
114AR_25329375_ChIP-Seq_VCAP_Human1.06267410
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05891946
116RNF2_27304074_Chip-Seq_NSC_Mouse1.04366559
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03979130
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03763902
119CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03305202
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02328249
121ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02019272
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01728711
123RUNX2_22187159_ChIP-Seq_PCA_Human1.01505201
124* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00990092
125* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00133686
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99883880
127HOXB7_26014856_ChIP-Seq_BT474_Human0.98683841
128NCOR_22424771_ChIP-Seq_293T_Human0.98498574
129SOX2_16153702_ChIP-ChIP_HESCs_Human0.97799554
130* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97682888
131FUS_26573619_Chip-Seq_HEK293_Human0.96608937
132FLI1_21867929_ChIP-Seq_TH2_Mouse0.96440892
133AR_21572438_ChIP-Seq_LNCaP_Human0.94746823
134* SMAD3_21741376_ChIP-Seq_EPCs_Human0.92583151
135GATA3_21878914_ChIP-Seq_MCF-7_Human0.90136198
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89384884
137KDM5A_27292631_Chip-Seq_BREAST_Human0.89075191
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88156951
139ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88062865
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83973385
141SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83721346
142CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83583577
143NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83569917
144PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83279998
145GBX2_23144817_ChIP-Seq_PC3_Human0.82363384
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79700247
147ELK1_22589737_ChIP-Seq_MCF10A_Human0.78840337
148NANOG_16153702_ChIP-ChIP_HESCs_Human0.78760295
149SALL1_21062744_ChIP-ChIP_HESCs_Human0.78245508
150NFE2_27457419_Chip-Seq_LIVER_Mouse0.75723252
151KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74406549
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73112225
153BMI1_23680149_ChIP-Seq_NPCS_Mouse0.69254333
154CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.66719311
155* SOX17_20123909_ChIP-Seq_XEN_Mouse0.65429882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.43961442
2MP0008057_abnormal_DNA_replication4.20608698
3MP0008058_abnormal_DNA_repair3.90977377
4MP0003693_abnormal_embryo_hatching3.58001039
5MP0010094_abnormal_chromosome_stability3.43400379
6MP0003111_abnormal_nucleus_morphology3.15770859
7MP0003136_yellow_coat_color2.82563620
8MP0004957_abnormal_blastocyst_morpholog2.76707683
9MP0000566_synostosis2.70476580
10MP0008877_abnormal_DNA_methylation2.56349088
11MP0003077_abnormal_cell_cycle2.46531733
12MP0001188_hyperpigmentation2.45339223
13MP0000569_abnormal_digit_pigmentation2.35985836
14MP0008007_abnormal_cellular_replicative2.29924131
15MP0002396_abnormal_hematopoietic_system2.26822201
16MP0005551_abnormal_eye_electrophysiolog2.14563808
17MP0002837_dystrophic_cardiac_calcinosis1.98317204
18MP0003786_premature_aging1.96859106
19MP0008932_abnormal_embryonic_tissue1.93227874
20MP0001968_abnormal_touch/_nociception1.92628072
21MP0004133_heterotaxia1.87118587
22MP0001529_abnormal_vocalization1.78866680
23MP0010030_abnormal_orbit_morphology1.76270805
24MP0009697_abnormal_copulation1.71266089
25MP0002102_abnormal_ear_morphology1.70581011
26MP0003121_genomic_imprinting1.66694687
27MP0002132_abnormal_respiratory_system1.62049285
28MP0003195_calcinosis1.60866932
29MP0003718_maternal_effect1.59483275
30MP0003646_muscle_fatigue1.59467776
31MP0002234_abnormal_pharynx_morphology1.59347952
32MP0004147_increased_porphyrin_level1.54586704
33MP0002938_white_spotting1.54536590
34MP0009046_muscle_twitch1.52401836
35MP0008789_abnormal_olfactory_epithelium1.52230617
36MP0002160_abnormal_reproductive_system1.52141024
37MP0002653_abnormal_ependyma_morphology1.45413431
38MP0005379_endocrine/exocrine_gland_phen1.44396488
39MP0005075_abnormal_melanosome_morpholog1.44066121
40MP0008872_abnormal_physiological_respon1.40657518
41MP0005171_absent_coat_pigmentation1.37920183
42MP0002735_abnormal_chemical_nociception1.36665336
43MP0005499_abnormal_olfactory_system1.36356509
44MP0005394_taste/olfaction_phenotype1.36356509
45MP0003787_abnormal_imprinting1.36093382
46MP0003880_abnormal_central_pattern1.35630965
47MP0000427_abnormal_hair_cycle1.35579692
48MP0009745_abnormal_behavioral_response1.34119502
49MP0000015_abnormal_ear_pigmentation1.32434703
50MP0004142_abnormal_muscle_tone1.29338406
51MP0009379_abnormal_foot_pigmentation1.25782968
52MP0002638_abnormal_pupillary_reflex1.24948156
53MP0003941_abnormal_skin_development1.23619970
54MP0001486_abnormal_startle_reflex1.22657629
55MP0008875_abnormal_xenobiotic_pharmacok1.22208146
56MP0002095_abnormal_skin_pigmentation1.21943087
57MP0001293_anophthalmia1.21860206
58MP0003123_paternal_imprinting1.21590915
59MP0005646_abnormal_pituitary_gland1.21495382
60MP0002272_abnormal_nervous_system1.20958773
61MP0003315_abnormal_perineum_morphology1.18888544
62MP0003122_maternal_imprinting1.18177257
63MP0000350_abnormal_cell_proliferation1.17117391
64MP0000049_abnormal_middle_ear1.16612755
65MP0002751_abnormal_autonomic_nervous1.15145229
66MP0002277_abnormal_respiratory_mucosa1.14667165
67MP0003938_abnormal_ear_development1.14158885
68MP0001986_abnormal_taste_sensitivity1.13683317
69MP0004215_abnormal_myocardial_fiber1.12566213
70MP0000490_abnormal_crypts_of1.12454482
71MP0000383_abnormal_hair_follicle1.12037217
72MP0001764_abnormal_homeostasis1.08624094
73MP0004381_abnormal_hair_follicle1.05691445
74MP0005409_darkened_coat_color1.05581211
75MP0002210_abnormal_sex_determination1.05251040
76MP0001485_abnormal_pinna_reflex1.05240509
77MP0003890_abnormal_embryonic-extraembry1.03819325
78MP0004145_abnormal_muscle_electrophysio1.03723906
79MP0005389_reproductive_system_phenotype1.03358616
80MP0000631_abnormal_neuroendocrine_gland1.00400947
81MP0002557_abnormal_social/conspecific_i1.00194445
82MP0004924_abnormal_behavior0.98199832
83MP0005386_behavior/neurological_phenoty0.98199832
84MP0008995_early_reproductive_senescence0.98134620
85MP0005195_abnormal_posterior_eye0.95721013
86MP0003937_abnormal_limbs/digits/tail_de0.95624237
87MP0005410_abnormal_fertilization0.95550103
88MP0006072_abnormal_retinal_apoptosis0.94230062
89MP0004043_abnormal_pH_regulation0.93754072
90MP0008004_abnormal_stomach_pH0.92898536
91MP0006036_abnormal_mitochondrial_physio0.92804794
92MP0005174_abnormal_tail_pigmentation0.92517292
93MP0002572_abnormal_emotion/affect_behav0.91361207
94MP0000647_abnormal_sebaceous_gland0.90870349
95MP0002249_abnormal_larynx_morphology0.89391238
96MP0000372_irregular_coat_pigmentation0.88695719
97MP0005645_abnormal_hypothalamus_physiol0.88114472
98MP0003011_delayed_dark_adaptation0.87489123
99MP0003137_abnormal_impulse_conducting0.87182240
100MP0002752_abnormal_somatic_nervous0.87072773
101MP0001501_abnormal_sleep_pattern0.86567238
102MP0003119_abnormal_digestive_system0.85140385
103MP0002067_abnormal_sensory_capabilities0.85002210
104MP0001145_abnormal_male_reproductive0.84201840
105MP0001286_abnormal_eye_development0.83831902
106MP0005084_abnormal_gallbladder_morpholo0.83539880
107MP0000313_abnormal_cell_death0.83355624
108MP0001929_abnormal_gametogenesis0.83163232
109MP0004742_abnormal_vestibular_system0.82162487
110MP0002736_abnormal_nociception_after0.81612753
111MP0002184_abnormal_innervation0.79870248
112MP0001730_embryonic_growth_arrest0.78474125
113MP0000653_abnormal_sex_gland0.78216007
114MP0001119_abnormal_female_reproductive0.77958220
115MP0005395_other_phenotype0.77804360
116MP0000778_abnormal_nervous_system0.77515745
117MP0002075_abnormal_coat/hair_pigmentati0.76110768
118MP0000678_abnormal_parathyroid_gland0.75821288
119MP0006276_abnormal_autonomic_nervous0.75149869
120MP0002085_abnormal_embryonic_tissue0.74821210
121MP0003943_abnormal_hepatobiliary_system0.74273877
122MP0001186_pigmentation_phenotype0.74253838
123MP0001672_abnormal_embryogenesis/_devel0.73719160
124MP0005380_embryogenesis_phenotype0.73719160
125MP0001984_abnormal_olfaction0.73165667
126MP0008260_abnormal_autophagy0.72744354
127MP0000026_abnormal_inner_ear0.72329256
128MP0005253_abnormal_eye_physiology0.72114340
129MP0000681_abnormal_thyroid_gland0.72036711
130MP0002233_abnormal_nose_morphology0.71332990
131MP0002163_abnormal_gland_morphology0.68713710
132MP0006035_abnormal_mitochondrial_morpho0.68521327
133MP0003755_abnormal_palate_morphology0.67909711
134MP0001919_abnormal_reproductive_system0.67558316
135MP0001348_abnormal_lacrimal_gland0.66897148
136MP0003698_abnormal_male_reproductive0.66027833
137MP0003878_abnormal_ear_physiology0.65747097
138MP0005377_hearing/vestibular/ear_phenot0.65747097
139MP0005391_vision/eye_phenotype0.63365588
140MP0002080_prenatal_lethality0.61976655
141MP0001697_abnormal_embryo_size0.61876057

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.36341158
2Chromsome breakage (HP:0040012)4.10441953
3Birth length less than 3rd percentile (HP:0003561)4.00111993
4Molar tooth sign on MRI (HP:0002419)3.71098909
5Abnormality of midbrain morphology (HP:0002418)3.71098909
6Supernumerary spleens (HP:0009799)3.65833590
7Nephronophthisis (HP:0000090)3.46369168
8Abnormality of the preputium (HP:0100587)3.27792628
9Reticulocytopenia (HP:0001896)3.10404217
10Asplenia (HP:0001746)3.07201993
11Oral leukoplakia (HP:0002745)3.06827028
12Abnormality of the renal medulla (HP:0100957)3.04194498
13Duplicated collecting system (HP:0000081)3.03059275
14Microvesicular hepatic steatosis (HP:0001414)2.96694443
15Abnormality of the labia minora (HP:0012880)2.95955585
16Meckel diverticulum (HP:0002245)2.91262601
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.89819785
18Abnormality of the renal cortex (HP:0011035)2.89307451
19Pancreatic fibrosis (HP:0100732)2.86148208
20Abnormality of the ileum (HP:0001549)2.84204980
213-Methylglutaconic aciduria (HP:0003535)2.81767071
22Chronic hepatic failure (HP:0100626)2.80595696
23Aplasia/Hypoplasia of the spleen (HP:0010451)2.78170337
24Abnormality of the renal collecting system (HP:0004742)2.77930782
25Breast hypoplasia (HP:0003187)2.77775147
26True hermaphroditism (HP:0010459)2.76745885
27Abnormality of the anterior horn cell (HP:0006802)2.70029532
28Degeneration of anterior horn cells (HP:0002398)2.70029532
29Pancreatic cysts (HP:0001737)2.67350998
30Septo-optic dysplasia (HP:0100842)2.67119169
31Congenital stationary night blindness (HP:0007642)2.64112308
32Type I transferrin isoform profile (HP:0003642)2.60700519
33Type II lissencephaly (HP:0007260)2.58084744
34Abnormality of chromosome stability (HP:0003220)2.55595254
35Medial flaring of the eyebrow (HP:0010747)2.55165872
36Cystic liver disease (HP:0006706)2.53486161
37Congenital primary aphakia (HP:0007707)2.52767876
38Abnormality of DNA repair (HP:0003254)2.50696092
39Absent radius (HP:0003974)2.49560361
40Abnormal respiratory motile cilium morphology (HP:0005938)2.48016150
41Abnormal respiratory epithelium morphology (HP:0012253)2.48016150
42Nephrogenic diabetes insipidus (HP:0009806)2.46738897
43Attenuation of retinal blood vessels (HP:0007843)2.46392258
44Gait imbalance (HP:0002141)2.45948860
45Pendular nystagmus (HP:0012043)2.45326371
46Sclerocornea (HP:0000647)2.43987534
47Preaxial hand polydactyly (HP:0001177)2.43914648
48Patellar aplasia (HP:0006443)2.42317258
49Bone marrow hypocellularity (HP:0005528)2.39900527
50Aplasia involving forearm bones (HP:0009822)2.39392375
51Absent forearm bone (HP:0003953)2.39392375
52Renal cortical cysts (HP:0000803)2.37186366
53Cerebral hypomyelination (HP:0006808)2.36360950
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.31212551
55Acute encephalopathy (HP:0006846)2.31193635
56Hyperventilation (HP:0002883)2.30822992
57Gaze-evoked nystagmus (HP:0000640)2.29019869
58Acute necrotizing encephalopathy (HP:0006965)2.27581394
59Cerebellar dysplasia (HP:0007033)2.25673292
60Rough bone trabeculation (HP:0100670)2.23874306
61Duplication of thumb phalanx (HP:0009942)2.22800711
62Aplasia/Hypoplasia of the patella (HP:0006498)2.21988469
63Hyperglycinemia (HP:0002154)2.21524235
64Premature graying of hair (HP:0002216)2.21295620
65Abnormality of the pons (HP:0007361)2.20899796
66Abnormal ciliary motility (HP:0012262)2.20559045
67Triphalangeal thumb (HP:0001199)2.20123718
68Abnormal biliary tract physiology (HP:0012439)2.18687687
69Bile duct proliferation (HP:0001408)2.18687687
70Duodenal stenosis (HP:0100867)2.17485157
71Small intestinal stenosis (HP:0012848)2.17485157
72Oligodactyly (hands) (HP:0001180)2.17278283
73Mitochondrial inheritance (HP:0001427)2.14856205
74Anencephaly (HP:0002323)2.13554972
75Abolished electroretinogram (ERG) (HP:0000550)2.13004013
76Congenital hepatic fibrosis (HP:0002612)2.12214331
77Absent thumb (HP:0009777)2.11573753
78Hypoplasia of the pons (HP:0012110)2.11373410
79Aplastic anemia (HP:0001915)2.11101469
80Adrenal hypoplasia (HP:0000835)2.09538038
81Hepatic necrosis (HP:0002605)2.09344802
82Tubular atrophy (HP:0000092)2.09159834
83Progressive macrocephaly (HP:0004481)2.09132498
84Poor coordination (HP:0002370)2.07915822
85Severe visual impairment (HP:0001141)2.06398287
86Horseshoe kidney (HP:0000085)2.04285647
87Bony spicule pigmentary retinopathy (HP:0007737)2.03797060
88Increased serum lactate (HP:0002151)2.03554685
89Inability to walk (HP:0002540)2.02929865
90Aplasia/Hypoplasia of the tibia (HP:0005772)2.01944414
91Increased CSF lactate (HP:0002490)2.01491287
92Abnormal number of erythroid precursors (HP:0012131)2.00305864
93Colon cancer (HP:0003003)1.99801978
94Pancytopenia (HP:0001876)1.99565802
95Median cleft lip (HP:0000161)1.99401584
96Abnormal mitochondria in muscle tissue (HP:0008316)1.99339719
97Medulloblastoma (HP:0002885)1.99283833
98Occipital encephalocele (HP:0002085)1.98947897
99Abnormality of alanine metabolism (HP:0010916)1.98354208
100Hyperalaninemia (HP:0003348)1.98354208
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98354208
102Methylmalonic acidemia (HP:0002912)1.97698709
103Hyperglycinuria (HP:0003108)1.97532156
104Lipid accumulation in hepatocytes (HP:0006561)1.97171185
105Microretrognathia (HP:0000308)1.97146699
106Hepatocellular necrosis (HP:0001404)1.94943541
107Myelodysplasia (HP:0002863)1.94727296
108Sloping forehead (HP:0000340)1.94726343
109Abnormal rod and cone electroretinograms (HP:0008323)1.94563685
110Genetic anticipation (HP:0003743)1.94338844
111Lissencephaly (HP:0001339)1.94009065
112Progressive cerebellar ataxia (HP:0002073)1.93982771
113Type 2 muscle fiber atrophy (HP:0003554)1.93826368
114Retinal dysplasia (HP:0007973)1.93825223
115Breech presentation (HP:0001623)1.92750795
116Optic nerve hypoplasia (HP:0000609)1.92098695
117Volvulus (HP:0002580)1.91112706
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90779401
119Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90429727
120Facial cleft (HP:0002006)1.90266698
121Abnormal hair whorl (HP:0010721)1.90139559
122Abnormal trabecular bone morphology (HP:0100671)1.88703003
123Aganglionic megacolon (HP:0002251)1.88130272
124Genital tract atresia (HP:0001827)1.87820649
125Increased hepatocellular lipid droplets (HP:0006565)1.87649198
126Abnormality of the duodenum (HP:0002246)1.87108321
127Abnormality of cells of the erythroid lineage (HP:0012130)1.86940878
128Progressive inability to walk (HP:0002505)1.86642194
129Hypothermia (HP:0002045)1.85387021
130Male pseudohermaphroditism (HP:0000037)1.85082976
131Clubbing of toes (HP:0100760)1.84882939
132Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84673965
133Agnosia (HP:0010524)1.84647694
134Thyroid-stimulating hormone excess (HP:0002925)1.84526914
135Abnormal respiratory motile cilium physiology (HP:0012261)1.84376144
136Ectopic kidney (HP:0000086)1.83606104
137Methylmalonic aciduria (HP:0012120)1.83592555
138Cerebral edema (HP:0002181)1.83061662
139Abnormality of glycine metabolism (HP:0010895)1.82960101
140Abnormality of serine family amino acid metabolism (HP:0010894)1.82960101
141Constricted visual fields (HP:0001133)1.82521876
142Optic disc pallor (HP:0000543)1.80904169
143Lactic acidosis (HP:0003128)1.80279613
144Small hand (HP:0200055)1.80205061
145Absent septum pellucidum (HP:0001331)1.80021018
146Abnormality of the septum pellucidum (HP:0007375)1.79278659
147Astigmatism (HP:0000483)1.79048218
148Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78353635
149Dandy-Walker malformation (HP:0001305)1.78253637
150Postaxial foot polydactyly (HP:0001830)1.78074006
151Furrowed tongue (HP:0000221)1.77604228
152Intestinal atresia (HP:0011100)1.77122833
153Pallor (HP:0000980)1.76997802
154Vaginal atresia (HP:0000148)1.76040345
155Hypoplasia of the radius (HP:0002984)1.75347661
156Aplasia/Hypoplasia of the sternum (HP:0006714)1.75197127
157Renal Fanconi syndrome (HP:0001994)1.75006931
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74636009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.70086306
2STK164.18638444
3BUB13.97986780
4WEE13.92352348
5MAP4K22.99347204
6CDC72.94201921
7CASK2.91512537
8VRK12.58435027
9EIF2AK32.22977673
10TSSK62.22554970
11WNK32.20567072
12SRPK12.16034086
13EIF2AK12.15930405
14BRSK22.01682875
15ACVR1B2.01665571
16MKNK22.01211647
17MKNK11.98080217
18ZAK1.95856058
19WNK41.82308318
20TNIK1.78897731
21SIK31.68495459
22PLK41.66130005
23BCKDK1.65793063
24PLK11.63218795
25CCNB11.62419716
26EIF2AK21.62237491
27CDK71.51253627
28MAP3K41.48571580
29TAOK31.47602209
30TRIM281.40716745
31TAOK21.38423735
32PRPF4B1.36902937
33PLK31.34655651
34VRK21.33899875
35BRSK11.31388571
36TLK11.31242348
37CDK81.27707096
38TTK1.27410581
39BCR1.24751938
40ADRBK21.23201292
41YES11.21912123
42OXSR11.21072203
43ATR1.20871125
44AURKA1.20751405
45NME21.20607071
46MAP2K71.19320949
47STK38L1.17853266
48CHEK21.16822798
49STK391.16776370
50NUAK11.13331688
51IRAK31.12102322
52AKT31.08942379
53GRK11.07448724
54BMPR1B1.07423549
55CSNK1G11.05500028
56NEK61.04223617
57DYRK21.00144383
58PASK0.99868779
59NEK20.96845753
60DYRK30.96531507
61AURKB0.96494639
62PIM20.96236690
63STK240.94940613
64MAP3K120.93086804
65BRD40.89289771
66CSNK1A1L0.88840208
67CSNK1G20.87188737
68TEC0.85481664
69MAPK130.83399343
70PAK30.82110664
71CAMKK20.79753048
72BRAF0.78663969
73RPS6KB20.74935774
74CHEK10.72429035
75PBK0.72299664
76PRKCE0.70175675
77CSNK2A10.69838391
78EPHA40.69581711
79ADRBK10.69405098
80EPHA20.62954250
81PDK20.62708239
82CSNK2A20.62252850
83ERBB30.61995391
84MAPKAPK50.61142241
85BMPR20.60707492
86CDK190.60195188
87PRKCI0.58544693
88KIT0.58419216
89PHKG10.56948394
90PHKG20.56948394
91ATM0.56521749
92LATS10.53602771
93FLT30.53180715
94STK30.52521216
95CDK10.51417776
96CDK20.51289478
97OBSCN0.50874180
98MUSK0.50554017
99TAF10.50022963
100PIK3CA0.48311887
101CDK30.48166409
102IRAK40.47925259
103PNCK0.44197800
104CSNK1A10.43847672
105PRKCG0.39165923
106NME10.38910883
107CSNK1G30.38617076
108PLK20.38448724
109CSNK1D0.38407915
110CAMK2A0.38264833
111TESK20.37254890
112PRKDC0.36899866
113PRKACA0.35744800
114PAK10.35474165
115DAPK20.35186782
116NEK10.35020016
117PRKACB0.34196824
118DYRK1A0.33821836
119RPS6KA50.33761040
120PINK10.33572360
121TXK0.32897036
122NTRK20.32270430
123TGFBR10.32243330
124MST40.31743559
125LYN0.31382902
126CDK40.31234194
127GRK70.30784918
128MAP2K60.29452101
129RPS6KA40.29322757
130MARK10.27939717
131TNK20.27347532
132INSRR0.27345651
133MATK0.27244985
134AKT20.27126730
135RPS6KB10.26622433
136CSNK1E0.26309457

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.56049838
2Mismatch repair_Homo sapiens_hsa034304.25739360
3RNA polymerase_Homo sapiens_hsa030203.90279562
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40877076
5Nucleotide excision repair_Homo sapiens_hsa034203.31921347
6Proteasome_Homo sapiens_hsa030503.21545522
7Homologous recombination_Homo sapiens_hsa034403.20867678
8Base excision repair_Homo sapiens_hsa034103.19377796
9Ribosome_Homo sapiens_hsa030103.17106777
10Fanconi anemia pathway_Homo sapiens_hsa034603.09635820
11Pyrimidine metabolism_Homo sapiens_hsa002402.94022771
12Spliceosome_Homo sapiens_hsa030402.91329496
13Basal transcription factors_Homo sapiens_hsa030222.39860814
14RNA transport_Homo sapiens_hsa030132.31446781
15Butanoate metabolism_Homo sapiens_hsa006502.20605393
16Cell cycle_Homo sapiens_hsa041102.19487166
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19036544
18One carbon pool by folate_Homo sapiens_hsa006702.11303667
19Propanoate metabolism_Homo sapiens_hsa006402.07995935
20Non-homologous end-joining_Homo sapiens_hsa034502.07864782
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03879109
22Purine metabolism_Homo sapiens_hsa002301.81925966
23RNA degradation_Homo sapiens_hsa030181.68397942
24Protein export_Homo sapiens_hsa030601.65846523
25Nitrogen metabolism_Homo sapiens_hsa009101.62666759
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61287090
27Oxidative phosphorylation_Homo sapiens_hsa001901.60289018
28Tryptophan metabolism_Homo sapiens_hsa003801.50714903
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46700211
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43495171
31Huntingtons disease_Homo sapiens_hsa050161.36566002
32Parkinsons disease_Homo sapiens_hsa050121.30968349
33mRNA surveillance pathway_Homo sapiens_hsa030151.30467869
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20989451
35Vitamin B6 metabolism_Homo sapiens_hsa007501.19598953
36Peroxisome_Homo sapiens_hsa041461.08133065
37Olfactory transduction_Homo sapiens_hsa047401.05609098
38p53 signaling pathway_Homo sapiens_hsa041151.03719650
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98673902
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.91486865
41beta-Alanine metabolism_Homo sapiens_hsa004100.90557437
42Nicotine addiction_Homo sapiens_hsa050330.89709973
43Steroid biosynthesis_Homo sapiens_hsa001000.86985327
44Folate biosynthesis_Homo sapiens_hsa007900.86392090
45Pyruvate metabolism_Homo sapiens_hsa006200.86261890
46Epstein-Barr virus infection_Homo sapiens_hsa051690.86231929
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83935091
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81615462
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79075417
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77915658
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76026873
52Fatty acid metabolism_Homo sapiens_hsa012120.75687672
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.73534270
54Alzheimers disease_Homo sapiens_hsa050100.73497561
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72966484
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71074918
57ABC transporters_Homo sapiens_hsa020100.70213421
58Morphine addiction_Homo sapiens_hsa050320.70137913
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69621329
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69458686
61Retinol metabolism_Homo sapiens_hsa008300.68212707
62Fatty acid degradation_Homo sapiens_hsa000710.67931590
63Chemical carcinogenesis_Homo sapiens_hsa052040.65152726
64Phototransduction_Homo sapiens_hsa047440.64712157
65Arachidonic acid metabolism_Homo sapiens_hsa005900.62236696
66Caffeine metabolism_Homo sapiens_hsa002320.62163873
67Oocyte meiosis_Homo sapiens_hsa041140.60025386
68Metabolic pathways_Homo sapiens_hsa011000.59084000
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58846063
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.57825594
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57142256
72Systemic lupus erythematosus_Homo sapiens_hsa053220.56777680
73Lysine degradation_Homo sapiens_hsa003100.55144573
74Glycerolipid metabolism_Homo sapiens_hsa005610.55034197
75Herpes simplex infection_Homo sapiens_hsa051680.53058363
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53041907
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52606281
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51480485
79GABAergic synapse_Homo sapiens_hsa047270.49417840
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49313246
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48869855
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47200456
83Fatty acid elongation_Homo sapiens_hsa000620.45621661
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.45385163
85N-Glycan biosynthesis_Homo sapiens_hsa005100.44567350
86Fatty acid biosynthesis_Homo sapiens_hsa000610.43457565
87Arginine and proline metabolism_Homo sapiens_hsa003300.41506638
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41193674
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39824922
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38476328
91Sulfur relay system_Homo sapiens_hsa041220.38365821
92Alcoholism_Homo sapiens_hsa050340.38148341
93Collecting duct acid secretion_Homo sapiens_hsa049660.37722701
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36555816
95Glutamatergic synapse_Homo sapiens_hsa047240.36321360
96Basal cell carcinoma_Homo sapiens_hsa052170.35080354
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34292348
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32807046
99Sphingolipid metabolism_Homo sapiens_hsa006000.32382363
100Regulation of autophagy_Homo sapiens_hsa041400.31179511
101Glutathione metabolism_Homo sapiens_hsa004800.30793729
102Wnt signaling pathway_Homo sapiens_hsa043100.29728521
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.28640225
104Selenocompound metabolism_Homo sapiens_hsa004500.26682751
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26229460
106HTLV-I infection_Homo sapiens_hsa051660.24456370
107Autoimmune thyroid disease_Homo sapiens_hsa053200.24107573
108Ether lipid metabolism_Homo sapiens_hsa005650.23897981
109Viral carcinogenesis_Homo sapiens_hsa052030.23319812
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23203773
111Circadian rhythm_Homo sapiens_hsa047100.19647813
112Linoleic acid metabolism_Homo sapiens_hsa005910.19375118
113Primary immunodeficiency_Homo sapiens_hsa053400.18684461
114Allograft rejection_Homo sapiens_hsa053300.18584086
115Serotonergic synapse_Homo sapiens_hsa047260.18143439
116Hedgehog signaling pathway_Homo sapiens_hsa043400.17624739
117Vibrio cholerae infection_Homo sapiens_hsa051100.17417263
118Hippo signaling pathway_Homo sapiens_hsa043900.17314009
119Vitamin digestion and absorption_Homo sapiens_hsa049770.17150926
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16787402
121Legionellosis_Homo sapiens_hsa051340.16253786
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15110063
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.15047019
124Fructose and mannose metabolism_Homo sapiens_hsa000510.12216992
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11401026
126Biosynthesis of amino acids_Homo sapiens_hsa012300.10841491
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09162257
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.08985641
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.08985494
130Cardiac muscle contraction_Homo sapiens_hsa042600.08967210
131Taste transduction_Homo sapiens_hsa047420.08912185
132Type I diabetes mellitus_Homo sapiens_hsa049400.08305430
133Melanoma_Homo sapiens_hsa052180.08100461
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.07393172
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07358276
136Rheumatoid arthritis_Homo sapiens_hsa053230.06816473

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