TSEN54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the tRNA splicing endonuclease complex, which catalyzes the removal of introns from precursor tRNAs. The complex is also implicated in pre-mRNA 3-prime end processing. Mutations in this gene result in pontocerebellar hypoplasia type 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.44127999
2GDP-mannose metabolic process (GO:0019673)5.04620774
3DNA deamination (GO:0045006)4.95230217
4formation of translation preinitiation complex (GO:0001731)4.55099687
5viral transcription (GO:0019083)4.51357723
6DNA strand elongation involved in DNA replication (GO:0006271)4.50620863
7DNA replication initiation (GO:0006270)4.46996920
8DNA unwinding involved in DNA replication (GO:0006268)4.44926975
9telomere maintenance via semi-conservative replication (GO:0032201)4.42890704
10translational termination (GO:0006415)4.42543839
11maturation of SSU-rRNA (GO:0030490)4.40875227
12DNA strand elongation (GO:0022616)4.37884536
13folic acid-containing compound biosynthetic process (GO:0009396)4.22471773
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22362049
15translational elongation (GO:0006414)4.19225889
16nucleobase biosynthetic process (GO:0046112)4.11707967
17regulation of gamma-delta T cell differentiation (GO:0045586)4.07696997
18IMP biosynthetic process (GO:0006188)4.02295254
19negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.91149276
20thymic T cell selection (GO:0045061)3.90355637
21negative T cell selection (GO:0043383)3.90258809
22protein localization to kinetochore (GO:0034501)3.88990838
23translational initiation (GO:0006413)3.88112489
24negative regulation of DNA-templated transcription, elongation (GO:0032785)3.84804747
25ribosomal small subunit biogenesis (GO:0042274)3.82342293
26negative thymic T cell selection (GO:0045060)3.80477600
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.78389984
28telomere maintenance via recombination (GO:0000722)3.75355584
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.71701675
30ribosome biogenesis (GO:0042254)3.70740819
31ribosomal large subunit biogenesis (GO:0042273)3.70303040
32purine nucleobase biosynthetic process (GO:0009113)3.67389595
33ribonucleoprotein complex biogenesis (GO:0022613)3.66841183
34protein targeting to ER (GO:0045047)3.65232354
35cotranslational protein targeting to membrane (GO:0006613)3.64305761
36positive thymic T cell selection (GO:0045059)3.63582410
37IMP metabolic process (GO:0046040)3.63129017
38mitotic nuclear envelope disassembly (GO:0007077)3.61414011
39negative regulation of cell killing (GO:0031342)3.52316830
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52316830
41positive regulation of gamma-delta T cell activation (GO:0046645)3.49470863
42pseudouridine synthesis (GO:0001522)3.48062874
43telomere maintenance via telomere lengthening (GO:0010833)3.46262158
44viral life cycle (GO:0019058)3.44877868
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.44377813
46mitotic recombination (GO:0006312)3.44042797
47protein localization to endoplasmic reticulum (GO:0070972)3.42423554
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.42231382
49cellular protein complex disassembly (GO:0043624)3.41080673
50ribosome assembly (GO:0042255)3.40523522
51nucleotide salvage (GO:0043173)3.40001023
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.31772121
53T cell selection (GO:0045058)3.30872106
54membrane disassembly (GO:0030397)3.30223528
55nuclear envelope disassembly (GO:0051081)3.30223528
56rRNA processing (GO:0006364)3.30015641
57tolerance induction (GO:0002507)3.29013333
58pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.26656665
59pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.25670364
60negative regulation of B cell apoptotic process (GO:0002903)3.25509093
61regulation of gamma-delta T cell activation (GO:0046643)3.24613359
62protein localization to chromosome, centromeric region (GO:0071459)3.24037405
63metallo-sulfur cluster assembly (GO:0031163)3.23091171
64iron-sulfur cluster assembly (GO:0016226)3.23091171
65pyrimidine nucleoside salvage (GO:0043097)3.21590424
66pyrimidine-containing compound salvage (GO:0008655)3.21590424
67NIK/NF-kappaB signaling (GO:0038061)3.20918751
68rRNA metabolic process (GO:0016072)3.20608653
69peptidyl-arginine omega-N-methylation (GO:0035247)3.19992738
70CTP metabolic process (GO:0046036)3.19171954
71CTP biosynthetic process (GO:0006241)3.19171954
72pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.16566530
73cellular response to interleukin-15 (GO:0071350)3.14486019
74protein complex disassembly (GO:0043241)3.14280407
75DNA replication checkpoint (GO:0000076)3.12180135
76mitotic metaphase plate congression (GO:0007080)3.11656487
77pentose metabolic process (GO:0019321)3.11341820
78viral mRNA export from host cell nucleus (GO:0046784)3.10491364
79DNA replication-dependent nucleosome organization (GO:0034723)3.09101825
80DNA replication-dependent nucleosome assembly (GO:0006335)3.09101825
81negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.08440117
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06963070
83regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.06123379
84pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.06097967
85pteridine-containing compound biosynthetic process (GO:0042559)3.05742739
86tRNA modification (GO:0006400)3.04359394
87positive T cell selection (GO:0043368)3.02479694
88nuclear-transcribed mRNA catabolic process (GO:0000956)3.01920277
89folic acid metabolic process (GO:0046655)3.00668869
90pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.98348823
91translation (GO:0006412)2.97956939
92base-excision repair, AP site formation (GO:0006285)2.96732307
93macromolecular complex disassembly (GO:0032984)2.96676611
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.95494256
95rRNA modification (GO:0000154)2.94731099
96nucleoside salvage (GO:0043174)2.93349988
97DNA duplex unwinding (GO:0032508)2.92724262
98pyrimidine nucleotide catabolic process (GO:0006244)2.90957289
99somatic hypermutation of immunoglobulin genes (GO:0016446)2.90184876
100somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90184876
101DNA geometric change (GO:0032392)2.89767141
102RNA catabolic process (GO:0006401)2.88121325
103antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88070815
104deoxyribonucleotide catabolic process (GO:0009264)2.88035262
105spliceosomal snRNP assembly (GO:0000387)2.87793671
106negative regulation of RNA splicing (GO:0033119)2.87783521
107mRNA catabolic process (GO:0006402)2.87169587
108purine deoxyribonucleotide catabolic process (GO:0009155)2.86820848
109antigen processing and presentation of endogenous antigen (GO:0019883)2.86748607
110regulation of mitochondrial translation (GO:0070129)2.86312726
111regulation of spindle organization (GO:0090224)2.83691790
112positive regulation of T cell mediated cytotoxicity (GO:0001916)2.81098706
113pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.78153319
114UMP biosynthetic process (GO:0006222)2.78153319
115pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.78153319
116UMP metabolic process (GO:0046049)2.78153319
117regulation of translational termination (GO:0006449)2.76863694
118deoxyribose phosphate catabolic process (GO:0046386)2.72857771
119nuclear pore organization (GO:0006999)2.71591439
120response to interleukin-15 (GO:0070672)2.71027266
121deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70765651
122metaphase plate congression (GO:0051310)2.68581105
123regulation of T cell mediated cytotoxicity (GO:0001914)2.66851330
124positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.65766734
125regulation of translational fidelity (GO:0006450)2.64966199
126telomere organization (GO:0032200)2.63257210
127negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.63186031
128autophagic vacuole fusion (GO:0000046)2.63057874
129anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62820662
130telomere maintenance (GO:0000723)2.62268679
131establishment of integrated proviral latency (GO:0075713)2.62256086
132transcription-coupled nucleotide-excision repair (GO:0006283)2.62204862
133CENP-A containing nucleosome assembly (GO:0034080)2.61276410
134RNA splicing, via transesterification reactions (GO:0000375)2.61271506
135mitotic sister chromatid segregation (GO:0000070)2.61234698
136RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.60907559
137mRNA splicing, via spliceosome (GO:0000398)2.60907559
138cellular component biogenesis (GO:0044085)2.60771581
139mucosal-associated lymphoid tissue development (GO:0048537)2.60277943
140Peyers patch development (GO:0048541)2.60277943
141regulation of mammary gland epithelial cell proliferation (GO:0033599)2.60028833
142mitochondrial RNA metabolic process (GO:0000959)2.58977181
143rRNA transcription (GO:0009303)2.57401463
144proline biosynthetic process (GO:0006561)2.56727955
145* ncRNA processing (GO:0034470)2.56565009
146translesion synthesis (GO:0019985)2.56485237
147nuclear envelope organization (GO:0006998)2.56471016
148ncRNA 3-end processing (GO:0043628)2.56087436
149chromatin remodeling at centromere (GO:0031055)2.55654675
150UTP biosynthetic process (GO:0006228)2.55615789
151pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.55242842
152cell cycle G1/S phase transition (GO:0044843)2.55234200
153G1/S transition of mitotic cell cycle (GO:0000082)2.55234200
154negative regulation of mRNA processing (GO:0050686)2.55093573
155snRNA processing (GO:0016180)2.54917218
156regulation of translation in response to stress (GO:0043555)2.54911685
157Arp2/3 complex-mediated actin nucleation (GO:0034314)2.54618062
158regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.54608692
159regulation of gene silencing by RNA (GO:0060966)2.54494904
160regulation of posttranscriptional gene silencing (GO:0060147)2.54494904
161regulation of gene silencing by miRNA (GO:0060964)2.54494904
162attachment of spindle microtubules to kinetochore (GO:0008608)2.53321589
163DNA replication-independent nucleosome organization (GO:0034724)2.52816384
164histone arginine methylation (GO:0034969)2.50867804
165tRNA methylation (GO:0030488)2.49953001
166leukocyte aggregation (GO:0070486)2.49949411
167antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49887069
168guanosine-containing compound biosynthetic process (GO:1901070)2.49645549
169transcription from mitochondrial promoter (GO:0006390)2.46494753
170positive regulation of granulocyte differentiation (GO:0030854)2.45170854
171cellular response to interleukin-4 (GO:0071353)2.44142767
172pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.42860964

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.90484395
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.06620954
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.95979299
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.98700191
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80361184
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73701310
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62917085
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59632561
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50796838
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.47095779
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46885648
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.39987103
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.38018690
14MYC_22102868_ChIP-Seq_BL_Human2.33666986
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29625645
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21909339
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19226303
18XRN2_22483619_ChIP-Seq_HELA_Human2.18113736
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14526317
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11587784
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.95566568
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94070598
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90693605
24VDR_23849224_ChIP-Seq_CD4+_Human1.89547281
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85550199
26P68_20966046_ChIP-Seq_HELA_Human1.84313794
27GABP_19822575_ChIP-Seq_HepG2_Human1.83185952
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.81929381
29LXR_22292898_ChIP-Seq_THP-1_Human1.79834035
30DCP1A_22483619_ChIP-Seq_HELA_Human1.76838007
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73948507
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73827018
33* MAF_26560356_Chip-Seq_TH2_Human1.71739752
34CIITA_25753668_ChIP-Seq_RAJI_Human1.71575719
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.68190378
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64655008
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63513358
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.62794766
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61830992
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61168128
41VDR_21846776_ChIP-Seq_THP-1_Human1.60872557
42AR_21909140_ChIP-Seq_LNCAP_Human1.60145018
43TTF2_22483619_ChIP-Seq_HELA_Human1.59693351
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59416172
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.57012373
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56851558
47BCL6_27268052_Chip-Seq_Bcells_Human1.56805516
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.54586488
49* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54094179
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53531551
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53518589
52BCOR_27268052_Chip-Seq_Bcells_Human1.48324649
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48119661
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47822869
55RACK7_27058665_Chip-Seq_MCF-7_Human1.47683372
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.47483244
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46922828
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46658380
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43396782
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.41755133
61* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41713473
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40945556
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38497308
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38118120
65* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37960331
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37400223
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37152735
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37083352
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36484787
70KDM5A_27292631_Chip-Seq_BREAST_Human1.36094584
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35810266
72* SRF_21415370_ChIP-Seq_HL-1_Mouse1.35408311
73PHF8_20622854_ChIP-Seq_HELA_Human1.35269774
74* CTCF_26484167_Chip-Seq_Bcells_Mouse1.34770433
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34230448
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33540355
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.32016044
78E2F1_20622854_ChIP-Seq_HELA_Human1.31993386
79SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.31967427
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29395001
81* FOXP1_21924763_ChIP-Seq_HESCs_Human1.27200096
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27020104
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25271484
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24779738
85* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24415911
86* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24157416
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23454745
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23430195
89MYB_26560356_Chip-Seq_TH2_Human1.23329208
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21342350
91VDR_24763502_ChIP-Seq_THP-1_Human1.21098986
92ZNF263_19887448_ChIP-Seq_K562_Human1.21007340
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20446696
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17858824
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17835447
96TFEB_21752829_ChIP-Seq_HELA_Human1.17553657
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17494028
98SMC4_20622854_ChIP-Seq_HELA_Human1.16865715
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16257513
100ELK1_19687146_ChIP-ChIP_HELA_Human1.15781501
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15385994
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14616076
103YY1_22570637_ChIP-Seq_MALME-3M_Human1.14256121
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13935802
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.11831540
106MYB_26560356_Chip-Seq_TH1_Human1.11557190
107* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11033205
108ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10962111
109* KDM2B_26808549_Chip-Seq_DND41_Human1.09864788
110P300_27268052_Chip-Seq_Bcells_Human1.09170480
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07518217
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06503222
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06137870
114* SPI1_23547873_ChIP-Seq_NB4_Human1.03710235
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03334124
116KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02445043
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02013004
118GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01901297
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00780073
120ELK3_25401928_ChIP-Seq_HUVEC_Human0.96690997
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96124761
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95945735
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95944371
124CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94677951
125* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93453707
126* UTX_26944678_Chip-Seq_JUKART_Human0.93217736
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93170997
128SCL_19346495_ChIP-Seq_HPC-7_Human0.92902506
129MAF_26560356_Chip-Seq_TH1_Human0.90914395
130MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90381998
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89432794
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89199639
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88859526
134CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87522832
135SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86100935
136TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85904268
137TCF7_22412390_ChIP-Seq_EML_Mouse0.84193133
138ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83645112
139OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82208304
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.82179698
141TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81069599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.31544007
2MP0004957_abnormal_blastocyst_morpholog3.62775772
3MP0008057_abnormal_DNA_replication3.44990551
4MP0010094_abnormal_chromosome_stability3.43480531
5MP0003111_abnormal_nucleus_morphology3.37463170
6MP0003077_abnormal_cell_cycle3.32764857
7MP0002396_abnormal_hematopoietic_system2.80256328
8MP0003123_paternal_imprinting2.41030188
9MP0008058_abnormal_DNA_repair2.34851185
10MP0008007_abnormal_cellular_replicative2.34701691
11MP0000490_abnormal_crypts_of2.18202314
12MP0010352_gastrointestinal_tract_polyps2.08391828
13MP0001730_embryonic_growth_arrest2.07462647
14MP0005000_abnormal_immune_tolerance2.01655263
15MP0005397_hematopoietic_system_phenotyp1.97199488
16MP0001545_abnormal_hematopoietic_system1.97199488
17MP0008932_abnormal_embryonic_tissue1.97187856
18MP0000350_abnormal_cell_proliferation1.94304753
19MP0004808_abnormal_hematopoietic_stem1.87256979
20MP0008995_early_reproductive_senescence1.86909123
21MP0003806_abnormal_nucleotide_metabolis1.84952793
22MP0004381_abnormal_hair_follicle1.83015315
23MP0009333_abnormal_splenocyte_physiolog1.81830244
24MP0005083_abnormal_biliary_tract1.73771137
25MP0009278_abnormal_bone_marrow1.67354713
26MP0001697_abnormal_embryo_size1.60740918
27MP0008872_abnormal_physiological_respon1.59907061
28MP0003567_abnormal_fetal_cardiomyocyte1.59386325
29MP0008875_abnormal_xenobiotic_pharmacok1.58647557
30MP0002163_abnormal_gland_morphology1.57703367
31MP0005380_embryogenesis_phenotype1.56298236
32MP0001672_abnormal_embryogenesis/_devel1.56298236
33MP0003763_abnormal_thymus_physiology1.54128897
34MP0002080_prenatal_lethality1.54005758
35MP0003984_embryonic_growth_retardation1.48409304
36MP0002086_abnormal_extraembryonic_tissu1.47276409
37MP0002088_abnormal_embryonic_growth/wei1.45682230
38MP0002398_abnormal_bone_marrow1.44452350
39MP0000313_abnormal_cell_death1.43370436
40MP0002019_abnormal_tumor_incidence1.42792785
41MP0003786_premature_aging1.42517651
42MP0010307_abnormal_tumor_latency1.41799056
43MP0000689_abnormal_spleen_morphology1.40564583
44MP0001790_abnormal_immune_system1.40357182
45MP0005387_immune_system_phenotype1.40357182
46MP0002722_abnormal_immune_system1.37990803
47MP0001919_abnormal_reproductive_system1.35974423
48MP0000685_abnormal_immune_system1.33661922
49MP0004197_abnormal_fetal_growth/weight/1.31546196
50MP0002148_abnormal_hypersensitivity_rea1.30953594
51MP0005377_hearing/vestibular/ear_phenot1.28200916
52MP0003878_abnormal_ear_physiology1.28200916
53MP0001348_abnormal_lacrimal_gland1.28055993
54MP0002085_abnormal_embryonic_tissue1.27898659
55MP0006054_spinal_hemorrhage1.26738210
56MP0000703_abnormal_thymus_morphology1.26614997
57MP0000678_abnormal_parathyroid_gland1.22843891
58MP0005075_abnormal_melanosome_morpholog1.20506322
59MP0003221_abnormal_cardiomyocyte_apopto1.19411013
60MP0002084_abnormal_developmental_patter1.19207266
61MP0002429_abnormal_blood_cell1.17108840
62MP0002796_impaired_skin_barrier1.15811888
63MP0009840_abnormal_foam_cell1.15154943
64MP0002822_catalepsy1.14520202
65MP0001845_abnormal_inflammatory_respons1.13794508
66MP0004185_abnormal_adipocyte_glucose1.12536025
67MP0003186_abnormal_redox_activity1.09377630
68MP0004947_skin_inflammation1.07138992
69MP0002419_abnormal_innate_immunity1.07029923
70MP0000858_altered_metastatic_potential1.06814640
71MP0006292_abnormal_olfactory_placode1.06282637
72MP0005501_abnormal_skin_physiology1.06157309
73MP0003121_genomic_imprinting1.06118415
74MP0005023_abnormal_wound_healing1.06085616
75MP0000358_abnormal_cell_content/1.04048096
76MP0004264_abnormal_extraembryonic_tissu1.04048013
77MP0003705_abnormal_hypodermis_morpholog1.03859034
78MP0005310_abnormal_salivary_gland1.03758814
79MP0000465_gastrointestinal_hemorrhage1.02901211
80MP0003656_abnormal_erythrocyte_physiolo1.02766189
81MP0002166_altered_tumor_susceptibility1.01764382
82MP0009379_abnormal_foot_pigmentation1.01448752
83MP0001346_abnormal_lacrimal_gland1.00177724
84MP0000716_abnormal_immune_system0.98386315
85MP0002098_abnormal_vibrissa_morphology0.96617521
86MP0003718_maternal_effect0.96021354
87MP0001764_abnormal_homeostasis0.95701849
88MP0003638_abnormal_response/metabolism_0.95350074
89MP0005451_abnormal_body_composition0.95211445
90MP0008260_abnormal_autophagy0.94666044
91MP0010155_abnormal_intestine_physiology0.94637992
92MP0000477_abnormal_intestine_morphology0.93625051
93MP0000470_abnormal_stomach_morphology0.92917704
94MP0003566_abnormal_cell_adhesion0.92451936
95MP0002132_abnormal_respiratory_system0.92119125
96MP0003119_abnormal_digestive_system0.91102015
97MP0002277_abnormal_respiratory_mucosa0.90413734
98MP0004133_heterotaxia0.89098942
99MP0001293_anophthalmia0.88912708
100MP0001800_abnormal_humoral_immune0.88898533
101MP0001873_stomach_inflammation0.88803617
102MP0001835_abnormal_antigen_presentation0.88432457
103MP0001853_heart_inflammation0.88170199
104MP0003866_abnormal_defecation0.87991267
105MP0006036_abnormal_mitochondrial_physio0.87967930
106MP0010030_abnormal_orbit_morphology0.87789137
107MP0008469_abnormal_protein_level0.87332802
108MP0001986_abnormal_taste_sensitivity0.87298978
109MP0005671_abnormal_response_to0.86778749
110MP0000598_abnormal_liver_morphology0.85625653
111MP0002693_abnormal_pancreas_physiology0.84651652
112MP0008877_abnormal_DNA_methylation0.83031101
113MP0000372_irregular_coat_pigmentation0.82663695
114MP0000383_abnormal_hair_follicle0.82551192
115MP0005389_reproductive_system_phenotype0.82542461
116MP0002405_respiratory_system_inflammati0.82216456
117MP0003724_increased_susceptibility_to0.81165721
118MP0003943_abnormal_hepatobiliary_system0.80702598
119MP0002420_abnormal_adaptive_immunity0.80644835
120MP0001819_abnormal_immune_cell0.79257666
121MP0002653_abnormal_ependyma_morphology0.78801587
122MP0002269_muscular_atrophy0.77601158
123MP0002249_abnormal_larynx_morphology0.77178339
124MP0003436_decreased_susceptibility_to0.77056080
125MP0001727_abnormal_embryo_implantation0.76657928
126MP0009643_abnormal_urine_homeostasis0.76558759
127MP0002452_abnormal_antigen_presenting0.76505001
128MP0001765_abnormal_ion_homeostasis0.75750612
129MP0005384_cellular_phenotype0.74478928
130MP0001663_abnormal_digestive_system0.74367584
131MP0000467_abnormal_esophagus_morphology0.74360664
132MP0002160_abnormal_reproductive_system0.73353200
133MP0002723_abnormal_immune_serum0.72930407
134MP0005379_endocrine/exocrine_gland_phen0.72768782
135MP0001881_abnormal_mammary_gland0.72155863
136MP0004147_increased_porphyrin_level0.71621565
137MP0001664_abnormal_digestion0.70563232
138MP0005220_abnormal_exocrine_pancreas0.70553735
139MP0005076_abnormal_cell_differentiation0.67601962
140MP0005025_abnormal_response_to0.65964618
141MP0005621_abnormal_cell_physiology0.65505337
142MP0002089_abnormal_postnatal_growth/wei0.65410359
143MP0005464_abnormal_platelet_physiology0.65023748
144MP0010630_abnormal_cardiac_muscle0.64677819
145MP0006035_abnormal_mitochondrial_morpho0.64599820
146MP0001915_intracranial_hemorrhage0.64383786
147MP0002210_abnormal_sex_determination0.63208963
148MP0009672_abnormal_birth_weight0.63197733
149MP0001849_ear_inflammation0.62812407
150MP0003191_abnormal_cellular_cholesterol0.61247505
151MP0009785_altered_susceptibility_to0.60865282

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.78400041
2Abnormal number of erythroid precursors (HP:0012131)4.49065738
3Reticulocytopenia (HP:0001896)4.42529197
4Thrombocytosis (HP:0001894)3.98806137
5Birth length less than 3rd percentile (HP:0003561)3.98758253
6Aplastic anemia (HP:0001915)3.94437854
7Seborrheic dermatitis (HP:0001051)3.50498254
8Severe combined immunodeficiency (HP:0004430)3.33549339
9Selective tooth agenesis (HP:0001592)3.25612971
10Oral leukoplakia (HP:0002745)3.24169471
11IgG deficiency (HP:0004315)3.19748355
12Multiple enchondromatosis (HP:0005701)3.18720844
13Colon cancer (HP:0003003)3.11809345
14Microretrognathia (HP:0000308)3.10409532
15Pallor (HP:0000980)3.07723585
16Panhypogammaglobulinemia (HP:0003139)3.05396746
17Breast hypoplasia (HP:0003187)2.99529747
18Ependymoma (HP:0002888)2.96605865
19Macrocytic anemia (HP:0001972)2.95976941
20Pustule (HP:0200039)2.95821936
21Agammaglobulinemia (HP:0004432)2.91137253
22Rough bone trabeculation (HP:0100670)2.87543125
23Elevated erythrocyte sedimentation rate (HP:0003565)2.85902819
24Cerebral palsy (HP:0100021)2.82654258
25Abnormality of the heme biosynthetic pathway (HP:0010472)2.80072703
26J-shaped sella turcica (HP:0002680)2.74094457
27Increased muscle lipid content (HP:0009058)2.68443361
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.64996021
29Premature graying of hair (HP:0002216)2.62202828
30IgM deficiency (HP:0002850)2.60179733
31Myelodysplasia (HP:0002863)2.56866234
32Basal cell carcinoma (HP:0002671)2.56750399
33Combined immunodeficiency (HP:0005387)2.51907142
34Absent thumb (HP:0009777)2.51067251
35Neurodegeneration (HP:0002180)2.48542570
36Degeneration of anterior horn cells (HP:0002398)2.47419162
37Abnormality of the anterior horn cell (HP:0006802)2.47419162
38Patellar aplasia (HP:0006443)2.47254195
39Trismus (HP:0000211)2.45462873
40Neoplasm of the pancreas (HP:0002894)2.43559452
41Granulocytopenia (HP:0001913)2.42546175
42Stomatitis (HP:0010280)2.42490549
4311 pairs of ribs (HP:0000878)2.40934213
44Abnormality of reticulocytes (HP:0004312)2.40842782
45Recurrent fungal infections (HP:0002841)2.40797702
46Amaurosis fugax (HP:0100576)2.40632983
47Concave nail (HP:0001598)2.39666109
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38317648
49Poikiloderma (HP:0001029)2.38247184
50Progressive muscle weakness (HP:0003323)2.37758965
51Increased intramyocellular lipid droplets (HP:0012240)2.37371532
52B lymphocytopenia (HP:0010976)2.37306727
53Septate vagina (HP:0001153)2.36520803
54Obstructive lung disease (HP:0006536)2.36156206
55Chronic obstructive pulmonary disease (HP:0006510)2.36156206
56Abnormality of B cell number (HP:0010975)2.35790780
57Eczematoid dermatitis (HP:0000976)2.32509714
58Hypertensive crisis (HP:0100735)2.30412894
59Aplasia/Hypoplasia of the patella (HP:0006498)2.30265127
60Medulloblastoma (HP:0002885)2.27191695
61Lipid accumulation in hepatocytes (HP:0006561)2.27169513
62Mitochondrial inheritance (HP:0001427)2.26030404
63Asplenia (HP:0001746)2.25904443
64Testicular atrophy (HP:0000029)2.23122011
65T lymphocytopenia (HP:0005403)2.20939023
66Meningitis (HP:0001287)2.18437907
67Recurrent viral infections (HP:0004429)2.17668664
68Myositis (HP:0100614)2.17097988
69Cerebral hypomyelination (HP:0006808)2.16657474
70Hepatocellular necrosis (HP:0001404)2.15631043
71Increased IgM level (HP:0003496)2.15572983
72Increased CSF lactate (HP:0002490)2.14273973
73Growth hormone excess (HP:0000845)2.14235595
74Broad distal phalanx of finger (HP:0009836)2.13739111
75Proximal placement of thumb (HP:0009623)2.13328250
76Lymphoma (HP:0002665)2.10374423
77Pancytopenia (HP:0001876)2.09858714
78Bone marrow hypocellularity (HP:0005528)2.09745399
79Encephalitis (HP:0002383)2.09732087
80Mediastinal lymphadenopathy (HP:0100721)2.09518260
81Supernumerary spleens (HP:0009799)2.09153224
82Cellular immunodeficiency (HP:0005374)2.08731688
83Abnormal delayed hypersensitivity skin test (HP:0002963)2.08270685
84Aplasia/Hypoplasia of the spleen (HP:0010451)2.08166139
85Deviation of the thumb (HP:0009603)2.08029712
86Type I transferrin isoform profile (HP:0003642)2.07100658
87Meckel diverticulum (HP:0002245)2.06679991
88Hypoparathyroidism (HP:0000829)2.06205841
89Agnosia (HP:0010524)2.06038955
90Abnormality of the ileum (HP:0001549)2.03564917
91Missing ribs (HP:0000921)2.03189386
92Petechiae (HP:0000967)2.02812497
93Truncus arteriosus (HP:0001660)2.01225957
94Abnormality of iron homeostasis (HP:0011031)2.00848855
95Chromsome breakage (HP:0040012)1.99463111
96Aplasia/Hypoplasia of the thymus (HP:0010515)1.98963298
97Glossoptosis (HP:0000162)1.98714816
98Carpal bone hypoplasia (HP:0001498)1.97861753
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96643458
100Gastrointestinal inflammation (HP:0004386)1.93845468
101Abnormality of T cell number (HP:0011839)1.92727605
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90040652
103Dicarboxylic aciduria (HP:0003215)1.90040652
104Premature ovarian failure (HP:0008209)1.89788092
105Increased serum lactate (HP:0002151)1.89491487
106Poor head control (HP:0002421)1.89232531
107Abnormal trabecular bone morphology (HP:0100671)1.89116466
108Abnormality of the preputium (HP:0100587)1.88889562
109Abnormality of pyrimidine metabolism (HP:0004353)1.88697721
110Joint swelling (HP:0001386)1.87367907
111Rhabdomyosarcoma (HP:0002859)1.87095504
112Abnormality of T cell physiology (HP:0011840)1.86988491
113Increased hepatocellular lipid droplets (HP:0006565)1.86951797
114Neutropenia (HP:0001875)1.86764298
115Abnormality of chromosome stability (HP:0003220)1.86730004
116Abnormal mitochondria in muscle tissue (HP:0008316)1.86657131
117Respiratory difficulties (HP:0002880)1.85168931
118Slender long bone (HP:0003100)1.84924066
119Hyperthyroidism (HP:0000836)1.84499080
120Increased IgE level (HP:0003212)1.84305349
121Abnormality of eosinophils (HP:0001879)1.83916341
122Tracheoesophageal fistula (HP:0002575)1.83502585
123Microvesicular hepatic steatosis (HP:0001414)1.82195771
124Verrucae (HP:0200043)1.82139143
125Papilloma (HP:0012740)1.82139143
126Pili torti (HP:0003777)1.81578121
127Prostate neoplasm (HP:0100787)1.81433818
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.81007843
129Squamous cell carcinoma (HP:0002860)1.79697793
130Abnormal number of incisors (HP:0011064)1.79607226
131Villous atrophy (HP:0011473)1.78320181
132Abnormality of small intestinal villus morphology (HP:0011472)1.78320181
133Diaphragmatic weakness (HP:0009113)1.77983825
134Lactic acidosis (HP:0003128)1.77730991
135Atresia of the external auditory canal (HP:0000413)1.77629325
136High pitched voice (HP:0001620)1.76071440
137Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75882804
138Abnormal protein glycosylation (HP:0012346)1.75755569
139Abnormal glycosylation (HP:0012345)1.75755569
140Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75755569
141Abnormal protein N-linked glycosylation (HP:0012347)1.75755569
142Lymphopenia (HP:0001888)1.75614360
143Stridor (HP:0010307)1.75503276
144Anorexia (HP:0002039)1.75220172
145Spastic diplegia (HP:0001264)1.73626783
146Abnormality of the calcaneus (HP:0008364)1.73611796
147Atrophy/Degeneration involving motor neurons (HP:0007373)1.71659779
148Preauricular skin tag (HP:0000384)1.70808697
149Absent radius (HP:0003974)1.69363698
150Duodenal stenosis (HP:0100867)1.67789283
151Small intestinal stenosis (HP:0012848)1.67789283
152Megaloblastic anemia (HP:0001889)1.67694520
153Acute lymphatic leukemia (HP:0006721)1.64993210
154Ragged-red muscle fibers (HP:0003200)1.64243348
155Reduced antithrombin III activity (HP:0001976)1.63643547
156Optic nerve coloboma (HP:0000588)1.63164821
157Cafe-au-lait spot (HP:0000957)1.60222125
158Increased serum ferritin (HP:0003281)1.59494355
159Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.58639447
160Decreased activity of mitochondrial respiratory chain (HP:0008972)1.58639447
161Abnormality of transition element cation homeostasis (HP:0011030)1.58253178
162Angiofibromas (HP:0010615)1.57524742
163Adenoma sebaceum (HP:0009720)1.57524742
164Abnormality of T cells (HP:0002843)1.56743599
165Skin tags (HP:0010609)1.54772818
166Aplasia/hypoplasia of the humerus (HP:0006507)1.54321907
167Increased nuchal translucency (HP:0010880)1.54139238
168Astrocytoma (HP:0009592)1.54073631
169Abnormality of the astrocytes (HP:0100707)1.54073631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.81608087
2BUB13.75372424
3VRK22.88961141
4ACVR1B2.88641647
5EIF2AK12.75723739
6CDC72.61871774
7NME22.56364706
8EEF2K2.54465248
9TAOK32.48191635
10NEK22.43800344
11RPS6KB22.37252371
12BRSK22.29349411
13FLT32.25923176
14MAP3K102.14509776
15SMG12.10021983
16STK162.07617294
17TXK1.99938682
18SIK11.98527484
19BCKDK1.95884096
20SCYL21.87532250
21PKN21.85332204
22TESK21.84631621
23TGFBR11.80528362
24PASK1.78846800
25RPS6KA41.77128009
26MAP4K11.75992773
27NME11.74176778
28DYRK31.73350709
29TNK21.64929626
30EIF2AK31.62477472
31KDR1.58475048
32CDK71.58090627
33MUSK1.55790459
34TSSK61.51543399
35MAP3K81.47474710
36STK101.45765752
37PLK11.45479507
38IRAK31.43368705
39NEK11.43275111
40ERN11.41588358
41TTK1.41264817
42CDK41.39939663
43IKBKE1.39521695
44MAP2K31.37118703
45RIPK41.36734966
46FES1.36274145
47BRSK11.34748532
48MAP4K21.31653262
49MAPKAPK31.29350264
50ATR1.28126426
51VRK11.24699886
52PIM21.24370687
53AURKB1.22748346
54TRIB31.19047546
55LRRK21.17465253
56MAP3K111.15543139
57PAK41.14301989
58PLK41.10377828
59ZAP701.09652773
60ITK1.09136537
61PIM11.06226712
62SRPK11.01876353
63IRAK40.99013011
64CHEK20.97696582
65BTK0.92231187
66CDK120.89954849
67JAK30.89115580
68LCK0.89074311
69FGFR40.88772710
70TLK10.88548723
71AURKA0.86233764
72BLK0.84622510
73KIT0.84487724
74EPHA20.82404922
75TAOK20.82344553
76CHEK10.82274327
77MKNK10.81350012
78MST1R0.80730955
79CDK80.78956823
80NUAK10.75814299
81PTK60.74634190
82MAP2K20.74297816
83MAP3K140.71253036
84CCNB10.71174638
85PAK20.71104255
86CSF1R0.70198581
87TAOK10.69227252
88LYN0.69035770
89TYK20.67070550
90SYK0.65778508
91STK40.65535450
92PIK3CA0.64700052
93GRK60.64130557
94PDK10.62816759
95PRKD20.62375023
96PRKCI0.61742978
97LIMK10.60579814
98MAP3K30.58923419
99PDPK10.58322307
100CDK20.57555224
101ILK0.57018739
102TESK10.56579070
103PAK10.56103303
104IKBKB0.53527927
105CHUK0.53024790
106CSNK2A20.52778577
107SIK30.51832407
108TBK10.51747470
109ALK0.51151405
110ATM0.50432352
111ZAK0.49890424
112RAF10.49570656
113MAPK110.49183267
114PRKCQ0.48987561
115MTOR0.48947403
116PRPF4B0.48126024
117HIPK20.47924728
118TEC0.47670411
119SIK20.47631917
120CSNK2A10.47277370
121PLK30.43378812
122AKT20.42833527
123CAMKK10.39641708
124MATK0.38957007
125WNK40.37463002
126HCK0.36323909
127MELK0.35830610
128CSK0.34631048
129MAPK150.34578936
130MAP2K60.34260745
131ARAF0.34128407
132RPS6KA20.33750135
133RPS6KA10.33568897
134DAPK10.32376543
135MAPKAPK20.32047712
136BRAF0.30319109
137PIK3CG0.30003890
138RPS6KA60.28963872
139TTN0.28556975
140RPS6KC10.28084084
141RPS6KL10.28084084
142CDK60.27627688
143RPS6KA50.27587567

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.91176595
2Mismatch repair_Homo sapiens_hsa034303.88691751
3Ribosome_Homo sapiens_hsa030103.76839749
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.29726691
5Base excision repair_Homo sapiens_hsa034103.07544455
6Spliceosome_Homo sapiens_hsa030402.92786847
7RNA transport_Homo sapiens_hsa030132.70035415
8RNA polymerase_Homo sapiens_hsa030202.67580875
9Proteasome_Homo sapiens_hsa030502.64167807
10Nucleotide excision repair_Homo sapiens_hsa034202.59227387
11One carbon pool by folate_Homo sapiens_hsa006702.54726640
12Homologous recombination_Homo sapiens_hsa034402.37934778
13Pyrimidine metabolism_Homo sapiens_hsa002402.37437741
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32173651
15Cell cycle_Homo sapiens_hsa041102.27180036
16T cell receptor signaling pathway_Homo sapiens_hsa046601.68000446
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64857509
18Folate biosynthesis_Homo sapiens_hsa007901.59519316
19Fanconi anemia pathway_Homo sapiens_hsa034601.57390880
20RNA degradation_Homo sapiens_hsa030181.53894066
21p53 signaling pathway_Homo sapiens_hsa041151.48584959
22Non-homologous end-joining_Homo sapiens_hsa034501.40706014
23Sulfur relay system_Homo sapiens_hsa041221.38096376
24Basal transcription factors_Homo sapiens_hsa030221.36788273
25Biosynthesis of amino acids_Homo sapiens_hsa012301.29589012
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22551843
27mRNA surveillance pathway_Homo sapiens_hsa030151.16274122
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.11749508
29Selenocompound metabolism_Homo sapiens_hsa004501.11070880
30Epstein-Barr virus infection_Homo sapiens_hsa051691.10798260
31Herpes simplex infection_Homo sapiens_hsa051681.10263025
32Purine metabolism_Homo sapiens_hsa002301.09918715
33Oxidative phosphorylation_Homo sapiens_hsa001901.08292731
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07300955
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05920147
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.03983918
37Pentose phosphate pathway_Homo sapiens_hsa000301.02730557
38Graft-versus-host disease_Homo sapiens_hsa053320.99635877
39Antigen processing and presentation_Homo sapiens_hsa046120.97761139
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96084116
41Allograft rejection_Homo sapiens_hsa053300.91582797
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.90647939
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90564741
44Autoimmune thyroid disease_Homo sapiens_hsa053200.88747311
45Viral carcinogenesis_Homo sapiens_hsa052030.88356734
46Galactose metabolism_Homo sapiens_hsa000520.86189588
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84351490
48Parkinsons disease_Homo sapiens_hsa050120.83503576
49Legionellosis_Homo sapiens_hsa051340.82842050
50Carbon metabolism_Homo sapiens_hsa012000.82816919
51Primary immunodeficiency_Homo sapiens_hsa053400.82073343
52N-Glycan biosynthesis_Homo sapiens_hsa005100.81567214
53Systemic lupus erythematosus_Homo sapiens_hsa053220.78731495
54Thyroid cancer_Homo sapiens_hsa052160.77267573
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76279140
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.76174807
57Fructose and mannose metabolism_Homo sapiens_hsa000510.76074416
58HTLV-I infection_Homo sapiens_hsa051660.75488169
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72306649
60Huntingtons disease_Homo sapiens_hsa050160.71741202
61Apoptosis_Homo sapiens_hsa042100.66375944
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65350497
63Shigellosis_Homo sapiens_hsa051310.64534134
64Small cell lung cancer_Homo sapiens_hsa052220.63177772
65Regulation of autophagy_Homo sapiens_hsa041400.62536574
66Acute myeloid leukemia_Homo sapiens_hsa052210.62384240
67Sulfur metabolism_Homo sapiens_hsa009200.62046429
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61528431
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59796668
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59219806
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58993440
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58392951
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58354445
74ABC transporters_Homo sapiens_hsa020100.57888012
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56742746
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55007957
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54951146
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54430416
79Measles_Homo sapiens_hsa051620.54189470
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.53619814
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53459567
82Chronic myeloid leukemia_Homo sapiens_hsa052200.53110702
83Hepatitis C_Homo sapiens_hsa051600.52064467
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49839836
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.49296286
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48911994
87Peroxisome_Homo sapiens_hsa041460.48807352
88Bladder cancer_Homo sapiens_hsa052190.48794368
89Glutathione metabolism_Homo sapiens_hsa004800.48449598
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48198657
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.47990930
92Arachidonic acid metabolism_Homo sapiens_hsa005900.46445927
93Notch signaling pathway_Homo sapiens_hsa043300.46159517
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45909293
95Vitamin digestion and absorption_Homo sapiens_hsa049770.45605918
96Hepatitis B_Homo sapiens_hsa051610.45339449
97B cell receptor signaling pathway_Homo sapiens_hsa046620.45325738
98Phenylalanine metabolism_Homo sapiens_hsa003600.45020806
99Type I diabetes mellitus_Homo sapiens_hsa049400.44590937
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.43357363
101Colorectal cancer_Homo sapiens_hsa052100.42495562
102VEGF signaling pathway_Homo sapiens_hsa043700.41308590
103Vitamin B6 metabolism_Homo sapiens_hsa007500.39890312
104MicroRNAs in cancer_Homo sapiens_hsa052060.39619349
105Other glycan degradation_Homo sapiens_hsa005110.37629524
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37584343
107Protein export_Homo sapiens_hsa030600.37171113
108Influenza A_Homo sapiens_hsa051640.36904229
109Alzheimers disease_Homo sapiens_hsa050100.35980797
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34929194
111Linoleic acid metabolism_Homo sapiens_hsa005910.34509333
112HIF-1 signaling pathway_Homo sapiens_hsa040660.34437033
113Oocyte meiosis_Homo sapiens_hsa041140.34352158
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31669699
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31464545
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30676501
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.27911721
118Leishmaniasis_Homo sapiens_hsa051400.27361920
119Hematopoietic cell lineage_Homo sapiens_hsa046400.26355146
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24847451
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24672539
122Metabolic pathways_Homo sapiens_hsa011000.23967231
123Lysine degradation_Homo sapiens_hsa003100.23935637
124Pancreatic cancer_Homo sapiens_hsa052120.23392961
125Osteoclast differentiation_Homo sapiens_hsa043800.23296969
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.22522151
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22152845
128Arginine and proline metabolism_Homo sapiens_hsa003300.21876259
129Non-small cell lung cancer_Homo sapiens_hsa052230.21129947
130Viral myocarditis_Homo sapiens_hsa054160.19676919
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19381034
132mTOR signaling pathway_Homo sapiens_hsa041500.19196799
133Pathways in cancer_Homo sapiens_hsa052000.18869531
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18393069

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »