TSG101

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)6.11853711
2protein deneddylation (GO:0000338)5.77881048
3proteasome assembly (GO:0043248)4.92858299
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.77390245
5positive regulation of mitochondrial fission (GO:0090141)4.57516814
6chaperone-mediated protein transport (GO:0072321)4.38318577
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.36593439
8positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.34975269
9piRNA metabolic process (GO:0034587)4.33662334
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.32523802
11negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.27978879
12negative regulation of ligase activity (GO:0051352)4.27978879
13regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.25435309
14ATP synthesis coupled proton transport (GO:0015986)4.13132827
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.13132827
16regulation of cellular amino acid metabolic process (GO:0006521)4.10848354
17DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.06520853
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.03785421
19iron-sulfur cluster assembly (GO:0016226)4.02736408
20metallo-sulfur cluster assembly (GO:0031163)4.02736408
21intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.98038983
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.98038983
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.93505095
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.93505095
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.93505095
26pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.92002217
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.90612882
28protein neddylation (GO:0045116)3.90219814
29signal transduction involved in cell cycle checkpoint (GO:0072395)3.77516145
302-deoxyribonucleotide biosynthetic process (GO:0009265)3.76922279
31deoxyribose phosphate biosynthetic process (GO:0046385)3.76922279
32signal transduction involved in DNA integrity checkpoint (GO:0072401)3.75691080
33signal transduction involved in DNA damage checkpoint (GO:0072422)3.75691080
34positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.73634235
35deoxyribonucleotide biosynthetic process (GO:0009263)3.69692683
36spliceosomal snRNP assembly (GO:0000387)3.64835709
37antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.62148679
38positive regulation of ligase activity (GO:0051351)3.62136717
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.61839035
40viral mRNA export from host cell nucleus (GO:0046784)3.60918315
41regulation of cilium movement (GO:0003352)3.52998591
42DNA strand elongation involved in DNA replication (GO:0006271)3.51914569
43regulation of meiosis I (GO:0060631)3.50735957
44de novo posttranslational protein folding (GO:0051084)3.50485802
45de novo protein folding (GO:0006458)3.49261818
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46178073
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46178073
48protein K11-linked ubiquitination (GO:0070979)3.43193484
49RNA capping (GO:0036260)3.42262094
507-methylguanosine RNA capping (GO:0009452)3.42262094
517-methylguanosine mRNA capping (GO:0006370)3.41924220
52telomere maintenance via semi-conservative replication (GO:0032201)3.38569895
53pyrimidine nucleobase catabolic process (GO:0006208)3.34935909
54protein complex biogenesis (GO:0070271)3.33508944
55guanosine-containing compound biosynthetic process (GO:1901070)3.32733065
56mannosylation (GO:0097502)3.32568315
57platelet dense granule organization (GO:0060155)3.32107895
58DNA strand elongation (GO:0022616)3.29404043
59establishment of integrated proviral latency (GO:0075713)3.28308429
60protein localization to cilium (GO:0061512)3.28123325
61DNA damage response, detection of DNA damage (GO:0042769)3.25283156
62signal peptide processing (GO:0006465)3.23887289
63regulation of ubiquitin-protein transferase activity (GO:0051438)3.23835156
64peroxisome fission (GO:0016559)3.23254091
65intraciliary transport (GO:0042073)3.20971149
66positive regulation of cell cycle arrest (GO:0071158)3.20820318
67melanosome localization (GO:0032400)3.19480960
68fatty acid elongation (GO:0030497)3.18624736
69GTP biosynthetic process (GO:0006183)3.18428864
70transcription elongation from RNA polymerase III promoter (GO:0006385)3.17716230
71termination of RNA polymerase III transcription (GO:0006386)3.17716230
72sequestering of actin monomers (GO:0042989)3.17052414
73regulation of ligase activity (GO:0051340)3.16422126
74anterograde synaptic vesicle transport (GO:0048490)3.15390499
75NADH dehydrogenase complex assembly (GO:0010257)3.15382638
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15382638
77mitochondrial respiratory chain complex I assembly (GO:0032981)3.15382638
78DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.14225170
79DNA methylation involved in gamete generation (GO:0043046)3.13327006
80ubiquinone biosynthetic process (GO:0006744)3.13302252
81establishment of melanosome localization (GO:0032401)3.13216137
82ubiquinone metabolic process (GO:0006743)3.12222261
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.11073361
84organelle disassembly (GO:1903008)3.10482052
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10137378
86nonmotile primary cilium assembly (GO:0035058)3.08570885
87respiratory chain complex IV assembly (GO:0008535)3.08375460
88nucleobase-containing small molecule interconversion (GO:0015949)3.07843943
89mitochondrial respiratory chain complex assembly (GO:0033108)3.07257838
90melanosome transport (GO:0032402)3.06895727
91pigment granule localization (GO:0051875)3.06613472
92DNA deamination (GO:0045006)3.06235079
93ribonucleoprotein complex disassembly (GO:0032988)3.04148084
94nucleotide-excision repair, DNA gap filling (GO:0006297)3.04036551
95maturation of SSU-rRNA (GO:0030490)3.03857565
96regulation of cellular amine metabolic process (GO:0033238)3.03683757
97peptidyl-histidine modification (GO:0018202)3.03492801
98protein-cofactor linkage (GO:0018065)3.03246718
99spliceosomal complex assembly (GO:0000245)3.01227012
100establishment of pigment granule localization (GO:0051905)2.99502120
101transcription-coupled nucleotide-excision repair (GO:0006283)2.99169891
102telomere maintenance via recombination (GO:0000722)2.99013869
103antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.98660230
104postreplication repair (GO:0006301)2.97967619
105DNA double-strand break processing (GO:0000729)2.97084272
106GMP metabolic process (GO:0046037)2.93984325
107pigment granule transport (GO:0051904)2.92845637
108inositol phosphate catabolic process (GO:0071545)2.91137426
109DNA replication checkpoint (GO:0000076)2.88829964
110negative regulation of protein ubiquitination (GO:0031397)2.87849881
111cell cycle G1/S phase transition (GO:0044843)2.86827958
112G1/S transition of mitotic cell cycle (GO:0000082)2.86827958
113pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.84716907
114L-methionine salvage (GO:0071267)2.84410867
115L-methionine biosynthetic process (GO:0071265)2.84410867
116amino acid salvage (GO:0043102)2.84410867
117negative regulation of microtubule polymerization (GO:0031115)2.83711994
118respiratory electron transport chain (GO:0022904)2.83080237
119pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.82963056
120establishment of viral latency (GO:0019043)2.82830098
121branched-chain amino acid catabolic process (GO:0009083)2.82741700
122regulation of cell cycle arrest (GO:0071156)2.81798485
123regulation of cofactor metabolic process (GO:0051193)2.80163979
124regulation of coenzyme metabolic process (GO:0051196)2.80163979
125pyrimidine nucleotide catabolic process (GO:0006244)2.79913323
126nucleobase catabolic process (GO:0046113)2.79144514
127electron transport chain (GO:0022900)2.78878878
128regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.77378750
129histone mRNA metabolic process (GO:0008334)2.77153943
130CENP-A containing nucleosome assembly (GO:0034080)2.77087189
131exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75653512
132UTP biosynthetic process (GO:0006228)2.75530422
133synapsis (GO:0007129)2.74741851
134nucleotide transmembrane transport (GO:1901679)2.73252612
135GPI anchor metabolic process (GO:0006505)2.72057531
136base-excision repair, AP site formation (GO:0006285)2.71062600
137mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.70919181
138positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.70919181
139negative regulation of cell cycle G1/S phase transition (GO:1902807)2.70683518
140negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.70683518
141negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.70623277
142histone H2A acetylation (GO:0043968)2.70440500
143protein targeting to mitochondrion (GO:0006626)2.70252391
144positive regulation of TOR signaling (GO:0032008)2.70123910
145regulation of mitochondrial fission (GO:0090140)2.69654871
146nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69470724
147deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.68958915
148epithelial cilium movement (GO:0003351)2.68602040
149dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.60514322
150C-terminal protein lipidation (GO:0006501)2.60212642
151GPI anchor biosynthetic process (GO:0006506)2.58894415
152regulation of acyl-CoA biosynthetic process (GO:0050812)2.58817971
153cholesterol biosynthetic process (GO:0006695)2.57163805
154protein localization to mitochondrion (GO:0070585)2.56079826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.91355684
2* GABP_17652178_ChIP-ChIP_JURKAT_Human4.33945824
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.89540967
4* EST1_17652178_ChIP-ChIP_JURKAT_Human3.80032943
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.74409862
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.72613767
7* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.52658814
8E2F7_22180533_ChIP-Seq_HELA_Human3.41576259
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.39463769
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.36949363
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.33131097
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32313858
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.09912562
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.99856744
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.95344753
16ZNF274_21170338_ChIP-Seq_K562_Hela2.79513609
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74337449
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72751155
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.68441105
20DCP1A_22483619_ChIP-Seq_HELA_Human2.57087751
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.56419739
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54647138
23XRN2_22483619_ChIP-Seq_HELA_Human2.52724356
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.51242177
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46352816
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.43666119
27VDR_23849224_ChIP-Seq_CD4+_Human2.40792463
28* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36554619
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.32538588
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31212353
31* GABP_19822575_ChIP-Seq_HepG2_Human2.29621291
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24631817
33* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.22761330
34TTF2_22483619_ChIP-Seq_HELA_Human2.19634763
35* ELK1_19687146_ChIP-ChIP_HELA_Human2.18474755
36MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00625174
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98299894
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.97754052
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94604638
40FOXP3_21729870_ChIP-Seq_TREG_Human1.93612758
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88957313
42* ELK1_22589737_ChIP-Seq_MCF10A_Human1.84993999
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.81715113
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81683574
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.81243076
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80292761
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78045409
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71857451
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71307156
50TAF15_26573619_Chip-Seq_HEK293_Human1.69578864
51IRF1_19129219_ChIP-ChIP_H3396_Human1.69419956
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68532102
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67223685
54GBX2_23144817_ChIP-Seq_PC3_Human1.62002262
55EWS_26573619_Chip-Seq_HEK293_Human1.56318844
56FUS_26573619_Chip-Seq_HEK293_Human1.50772896
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49898124
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47215938
59* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44385812
60HTT_18923047_ChIP-ChIP_STHdh_Human1.41704216
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41271142
62TP53_22573176_ChIP-Seq_HFKS_Human1.41241593
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39811288
64P300_19829295_ChIP-Seq_ESCs_Human1.38310864
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.37817964
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35601196
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35594647
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32870114
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32850363
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32742072
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31502639
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29435859
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28113601
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27544207
75CIITA_25753668_ChIP-Seq_RAJI_Human1.26756931
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25166368
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24851085
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19963533
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19922954
80CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.19308939
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17961901
82IGF1R_20145208_ChIP-Seq_DFB_Human1.17121544
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.16183515
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15671429
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11175227
86CBP_20019798_ChIP-Seq_JUKART_Human1.11175227
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10749894
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10265418
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09481528
90ER_23166858_ChIP-Seq_MCF-7_Human1.09475944
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09235785
92* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09161771
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08422745
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08111961
95MYC_18940864_ChIP-ChIP_HL60_Human1.07909157
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07316678
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06245882
98TFEB_21752829_ChIP-Seq_HELA_Human1.06109660
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05534836
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05104599
101SOX17_20123909_ChIP-Seq_XEN_Mouse1.04066125
102* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02686598
103AR_20517297_ChIP-Seq_VCAP_Human1.01813312
104SOX2_19829295_ChIP-Seq_ESCs_Human1.01738272
105NANOG_19829295_ChIP-Seq_ESCs_Human1.01738272
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01283778
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.99416421
108* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98889150
109* FOXA1_25329375_ChIP-Seq_VCAP_Human0.98889150
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98746963
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98644766
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98488297
113TAL1_26923725_Chip-Seq_HPCs_Mouse0.97756122
114* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97646141
115AR_21909140_ChIP-Seq_LNCAP_Human0.97095766
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96465023
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96196137
118FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95154282
119TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93927388
120* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93432167
121CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92657804
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91505399
123NCOR_22424771_ChIP-Seq_293T_Human0.90800552
124E2F1_21310950_ChIP-Seq_MCF-7_Human0.90331103
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90157269
126AR_25329375_ChIP-Seq_VCAP_Human0.90133380
127SMAD4_21799915_ChIP-Seq_A2780_Human0.89029870
128REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88819446
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87914572
130NOTCH1_21737748_ChIP-Seq_TLL_Human0.87294209
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.87275033
132PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86580070
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86096249
134* CBP_21632823_ChIP-Seq_H3396_Human0.85977965
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85832190
136VDR_22108803_ChIP-Seq_LS180_Human0.85656999
137EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85618113
138NANOG_16153702_ChIP-ChIP_HESCs_Human0.85050487
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84317719
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.84165246
141PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.83305343
142* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81960917
143* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81915718
144KDM5A_27292631_Chip-Seq_BREAST_Human0.81670442
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81629874
146NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78620783
147* YY1_22570637_ChIP-Seq_MALME-3M_Human0.78245803
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78145556
149SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77554374
150SOX2_16153702_ChIP-ChIP_HESCs_Human0.76960173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006276_abnormal_autonomic_nervous2.91151769
2MP0010030_abnormal_orbit_morphology2.80536440
3MP0008789_abnormal_olfactory_epithelium2.74466715
4MP0002638_abnormal_pupillary_reflex2.70607525
5MP0003693_abnormal_embryo_hatching2.69377279
6MP0008877_abnormal_DNA_methylation2.68164482
7MP0001529_abnormal_vocalization2.42934492
8* MP0008932_abnormal_embryonic_tissue2.35743136
9MP0008007_abnormal_cellular_replicative2.34157574
10MP0006035_abnormal_mitochondrial_morpho2.28944552
11MP0002938_white_spotting2.25497127
12MP0006292_abnormal_olfactory_placode2.24018901
13MP0004957_abnormal_blastocyst_morpholog2.23103089
14MP0002102_abnormal_ear_morphology2.21733321
15MP0003315_abnormal_perineum_morphology2.21024941
16MP0002163_abnormal_gland_morphology2.20758669
17MP0003122_maternal_imprinting2.18308266
18MP0003123_paternal_imprinting2.17156210
19MP0009379_abnormal_foot_pigmentation2.12764316
20MP0005075_abnormal_melanosome_morpholog2.07401678
21MP0006036_abnormal_mitochondrial_physio2.02466588
22MP0002653_abnormal_ependyma_morphology1.96800294
23MP0002751_abnormal_autonomic_nervous1.96005376
24MP0008058_abnormal_DNA_repair1.93871882
25MP0002282_abnormal_trachea_morphology1.88216197
26MP0010094_abnormal_chromosome_stability1.81804961
27* MP0003077_abnormal_cell_cycle1.77606726
28MP0003121_genomic_imprinting1.76473458
29MP0000049_abnormal_middle_ear1.76285402
30MP0001188_hyperpigmentation1.74024604
31MP0002822_catalepsy1.73782157
32MP0002837_dystrophic_cardiac_calcinosis1.68334083
33MP0001984_abnormal_olfaction1.67323743
34MP0005394_taste/olfaction_phenotype1.65353717
35MP0005499_abnormal_olfactory_system1.65353717
36MP0002160_abnormal_reproductive_system1.64926523
37MP0005084_abnormal_gallbladder_morpholo1.63686169
38MP0000566_synostosis1.61566690
39MP0009697_abnormal_copulation1.61055880
40MP0003806_abnormal_nucleotide_metabolis1.60022234
41MP0000778_abnormal_nervous_system1.58405386
42MP0010386_abnormal_urinary_bladder1.55763554
43MP0005408_hypopigmentation1.54686201
44MP0006072_abnormal_retinal_apoptosis1.52168611
45MP0001905_abnormal_dopamine_level1.48552239
46MP0003880_abnormal_central_pattern1.48392461
47MP0003011_delayed_dark_adaptation1.47047295
48MP0003942_abnormal_urinary_system1.46935506
49MP0004147_increased_porphyrin_level1.46020409
50MP0003186_abnormal_redox_activity1.45986955
51MP0004142_abnormal_muscle_tone1.44753477
52MP0000537_abnormal_urethra_morphology1.44579034
53MP0003195_calcinosis1.44257252
54MP0003786_premature_aging1.41793714
55MP0004133_heterotaxia1.39731343
56MP0003941_abnormal_skin_development1.38176265
57MP0000538_abnormal_urinary_bladder1.34983390
58MP0002090_abnormal_vision1.34803160
59MP0004215_abnormal_myocardial_fiber1.34271420
60MP0000631_abnormal_neuroendocrine_gland1.33884954
61MP0005367_renal/urinary_system_phenotyp1.32597032
62MP0000516_abnormal_urinary_system1.32597032
63MP0005253_abnormal_eye_physiology1.31132652
64MP0009250_abnormal_appendicular_skeleto1.30962355
65MP0004270_analgesia1.30551845
66MP0003111_abnormal_nucleus_morphology1.30147913
67MP0001764_abnormal_homeostasis1.28601236
68MP0003119_abnormal_digestive_system1.27795055
69MP0006054_spinal_hemorrhage1.27158509
70MP0002184_abnormal_innervation1.26939693
71MP0000358_abnormal_cell_content/1.22654866
72MP0009046_muscle_twitch1.16881185
73MP0000372_irregular_coat_pigmentation1.16201458
74MP0005220_abnormal_exocrine_pancreas1.16028614
75MP0001929_abnormal_gametogenesis1.12640613
76MP0002272_abnormal_nervous_system1.11080236
77MP0008875_abnormal_xenobiotic_pharmacok1.10746958
78MP0000647_abnormal_sebaceous_gland1.09997566
79MP0002234_abnormal_pharynx_morphology1.07954652
80MP0003718_maternal_effect1.07649283
81MP0001986_abnormal_taste_sensitivity1.07503898
82MP0002177_abnormal_outer_ear1.04403944
83MP0000015_abnormal_ear_pigmentation1.04014488
84MP0000678_abnormal_parathyroid_gland1.03633411
85MP0000749_muscle_degeneration1.02764495
86MP0002095_abnormal_skin_pigmentation1.02579024
87MP0001286_abnormal_eye_development1.02112270
88MP0005645_abnormal_hypothalamus_physiol0.99620568
89MP0002876_abnormal_thyroid_physiology0.97904010
90MP0003385_abnormal_body_wall0.95389677
91MP0005379_endocrine/exocrine_gland_phen0.93792160
92MP0003221_abnormal_cardiomyocyte_apopto0.93210037
93MP0004924_abnormal_behavior0.92405501
94MP0005386_behavior/neurological_phenoty0.92405501
95MP0000681_abnormal_thyroid_gland0.91412031
96MP0001542_abnormal_bone_strength0.91403023
97MP0005423_abnormal_somatic_nervous0.91168292
98MP0001324_abnormal_eye_pigmentation0.89836526
99MP0001879_abnormal_lymphatic_vessel0.89531763
100MP0000653_abnormal_sex_gland0.89468316
101MP0009053_abnormal_anal_canal0.89417524
102MP0002752_abnormal_somatic_nervous0.88842557
103MP0003755_abnormal_palate_morphology0.87818318
104MP0003698_abnormal_male_reproductive0.87748828
105* MP0000350_abnormal_cell_proliferation0.86907570
106MP0009745_abnormal_behavioral_response0.86684429
107MP0004043_abnormal_pH_regulation0.84741434
108MP0002233_abnormal_nose_morphology0.84625420
109MP0002909_abnormal_adrenal_gland0.84574812
110MP0003567_abnormal_fetal_cardiomyocyte0.84053043
111MP0003861_abnormal_nervous_system0.83984223
112MP0003938_abnormal_ear_development0.83808262
113MP0002132_abnormal_respiratory_system0.83210521
114MP0003937_abnormal_limbs/digits/tail_de0.82511805
115MP0000613_abnormal_salivary_gland0.82312093
116MP0005503_abnormal_tendon_morphology0.81949834
117MP0005248_abnormal_Harderian_gland0.81885139
118MP0001970_abnormal_pain_threshold0.81331441
119MP0002210_abnormal_sex_determination0.81033318
120MP0001270_distended_abdomen0.80389355
121MP0004811_abnormal_neuron_physiology0.80120171
122MP0000534_abnormal_ureter_morphology0.79491303
123MP0002734_abnormal_mechanical_nocicepti0.78674157
124MP0005389_reproductive_system_phenotype0.78649688
125MP0001145_abnormal_male_reproductive0.78252364
126MP0002736_abnormal_nociception_after0.77645842
127MP0001968_abnormal_touch/_nociception0.77155574
128MP0001727_abnormal_embryo_implantation0.77007369
129MP0001293_anophthalmia0.77004031
130MP0002735_abnormal_chemical_nociception0.76923652
131MP0002557_abnormal_social/conspecific_i0.75877834
132MP0008260_abnormal_autophagy0.75789556
133MP0000026_abnormal_inner_ear0.75725743
134* MP0001697_abnormal_embryo_size0.75651491
135MP0002069_abnormal_eating/drinking_beha0.75089662
136MP0002332_abnormal_exercise_endurance0.74172226
137MP0000750_abnormal_muscle_regeneration0.73793962
138MP0005551_abnormal_eye_electrophysiolog0.72397554
139MP0000013_abnormal_adipose_tissue0.71814692
140MP0005332_abnormal_amino_acid0.71670557
141MP0002116_abnormal_craniofacial_bone0.71262547
142MP0005266_abnormal_metabolism0.70832687
143MP0009333_abnormal_splenocyte_physiolog0.70596741
144MP0008995_early_reproductive_senescence0.70571222
145MP0000569_abnormal_digit_pigmentation0.70516853
146MP0005410_abnormal_fertilization0.70370482
147MP0002572_abnormal_emotion/affect_behav0.70083782
148MP0005395_other_phenotype0.69607037
149MP0005187_abnormal_penis_morphology0.68348605
150MP0002277_abnormal_respiratory_mucosa0.67999600
151MP0008872_abnormal_physiological_respon0.67892703
152* MP0002085_abnormal_embryonic_tissue0.67377599
153MP0003656_abnormal_erythrocyte_physiolo0.67293753

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.36198142
2Increased serum pyruvate (HP:0003542)4.36198142
3Acute necrotizing encephalopathy (HP:0006965)4.03326907
4Abnormal mitochondria in muscle tissue (HP:0008316)3.79462660
5Decreased activity of mitochondrial respiratory chain (HP:0008972)3.72744927
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.72744927
7Mitochondrial inheritance (HP:0001427)3.70315167
8Hepatocellular necrosis (HP:0001404)3.55239242
9Hypothermia (HP:0002045)3.38881399
10Increased CSF lactate (HP:0002490)3.23914240
11Progressive macrocephaly (HP:0004481)3.14018376
12Hepatic necrosis (HP:0002605)3.01352012
13Degeneration of anterior horn cells (HP:0002398)2.86560068
14Abnormality of the anterior horn cell (HP:0006802)2.86560068
15Methylmalonic acidemia (HP:0002912)2.84781230
16Acute encephalopathy (HP:0006846)2.84617180
17Increased serum lactate (HP:0002151)2.69918330
18Severe visual impairment (HP:0001141)2.68447023
19Irregular epiphyses (HP:0010582)2.65733615
20Molar tooth sign on MRI (HP:0002419)2.65558590
21Abnormality of midbrain morphology (HP:0002418)2.65558590
22Oligodactyly (hands) (HP:0001180)2.62476257
23Neuroendocrine neoplasm (HP:0100634)2.60199935
24Oral leukoplakia (HP:0002745)2.59949403
25Patellar aplasia (HP:0006443)2.58725263
26Retinal dysplasia (HP:0007973)2.57890517
27Type I transferrin isoform profile (HP:0003642)2.57072223
28Birth length less than 3rd percentile (HP:0003561)2.55490555
29Abnormal hair whorl (HP:0010721)2.55441001
30Nephrogenic diabetes insipidus (HP:0009806)2.52738786
31Atrophy/Degeneration involving motor neurons (HP:0007373)2.51329834
32Gait imbalance (HP:0002141)2.50804318
33Pheochromocytoma (HP:0002666)2.49510405
34Abnormal rod and cone electroretinograms (HP:0008323)2.48961087
35Short tibia (HP:0005736)2.48696229
36Methylmalonic aciduria (HP:0012120)2.48170522
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.47999347
38Abnormality of the labia minora (HP:0012880)2.47976357
39Aplastic anemia (HP:0001915)2.45979479
40Rough bone trabeculation (HP:0100670)2.44632629
413-Methylglutaconic aciduria (HP:0003535)2.44535954
42Congenital primary aphakia (HP:0007707)2.44481899
43Exercise intolerance (HP:0003546)2.43324505
44Renal cortical cysts (HP:0000803)2.42598651
45Neoplasm of the adrenal gland (HP:0100631)2.42441473
46True hermaphroditism (HP:0010459)2.42343741
47Medial flaring of the eyebrow (HP:0010747)2.42333410
48Increased hepatocellular lipid droplets (HP:0006565)2.41383622
49Aplasia/Hypoplasia of the patella (HP:0006498)2.39507629
50Cerebral edema (HP:0002181)2.38955100
51Esophageal neoplasm (HP:0100751)2.35572409
52Neoplasm of head and neck (HP:0012288)2.35572409
53Gonadotropin excess (HP:0000837)2.30238540
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28713501
55Abnormality of alanine metabolism (HP:0010916)2.28713501
56Hyperalaninemia (HP:0003348)2.28713501
57Lissencephaly (HP:0001339)2.27979615
58Limb dystonia (HP:0002451)2.27589607
59Lipid accumulation in hepatocytes (HP:0006561)2.27424438
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.27392446
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27352294
62Hyperglycinemia (HP:0002154)2.24623514
63Optic disc pallor (HP:0000543)2.24554392
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24461020
65Generalized aminoaciduria (HP:0002909)2.23109099
66Lactic acidosis (HP:0003128)2.22884702
67Pendular nystagmus (HP:0012043)2.21484799
68Breast hypoplasia (HP:0003187)2.20030642
69Amyotrophic lateral sclerosis (HP:0007354)2.18474680
70Supernumerary spleens (HP:0009799)2.17608486
71Rimmed vacuoles (HP:0003805)2.16515523
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.14942366
73Respiratory failure (HP:0002878)2.14922479
74Abnormality of the fovea (HP:0000493)2.14382377
75Bifid tongue (HP:0010297)2.14125127
76Hand muscle atrophy (HP:0009130)2.13794003
77Hypoplasia of the fovea (HP:0007750)2.13601478
78Aplasia/Hypoplasia of the fovea (HP:0008060)2.13601478
79Median cleft lip (HP:0000161)2.11445305
80Heterochromia iridis (HP:0001100)2.09059573
81Reticulocytopenia (HP:0001896)2.08316834
82Cerebral hypomyelination (HP:0006808)2.08041579
83Pancreatic cysts (HP:0001737)2.07211562
84Poor head control (HP:0002421)2.03252584
85Pancreatic fibrosis (HP:0100732)2.03196223
86Oligodactyly (HP:0012165)2.02761343
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02412722
88Split foot (HP:0001839)2.02216018
89Renal Fanconi syndrome (HP:0001994)2.01257297
90Vaginal atresia (HP:0000148)2.00540606
91Nephronophthisis (HP:0000090)1.99077975
92Optic nerve coloboma (HP:0000588)1.98283974
93Abnormal trabecular bone morphology (HP:0100671)1.97749467
94Parakeratosis (HP:0001036)1.97213074
95CNS demyelination (HP:0007305)1.97170725
96Polyphagia (HP:0002591)1.96382821
97Abolished electroretinogram (ERG) (HP:0000550)1.95175720
98Tubulointerstitial nephritis (HP:0001970)1.94919696
99Genital tract atresia (HP:0001827)1.93620801
100Failure to thrive in infancy (HP:0001531)1.92807163
101Central scotoma (HP:0000603)1.91096700
102Esotropia (HP:0000565)1.90955268
103Upper limb muscle weakness (HP:0003484)1.90268988
104Cortical dysplasia (HP:0002539)1.90212148
105Lethargy (HP:0001254)1.89008965
106Postaxial hand polydactyly (HP:0001162)1.87188767
107Type II lissencephaly (HP:0007260)1.87176375
108Bony spicule pigmentary retinopathy (HP:0007737)1.86993126
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.85354573
110Abnormality of the renal cortex (HP:0011035)1.85286146
111Postnatal microcephaly (HP:0005484)1.85097653
112Exertional dyspnea (HP:0002875)1.85066312
113Abnormal glycosylation (HP:0012345)1.84159577
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84159577
115Abnormal protein N-linked glycosylation (HP:0012347)1.84159577
116Abnormal protein glycosylation (HP:0012346)1.84159577
117Decreased testicular size (HP:0008734)1.82564294
118Limb-girdle muscle atrophy (HP:0003797)1.81018462
119Increased muscle lipid content (HP:0009058)1.80855022
120Increased intramyocellular lipid droplets (HP:0012240)1.79044678
121Adrenal hypoplasia (HP:0000835)1.78706026
122Sclerocornea (HP:0000647)1.78093921
123Abnormal lung lobation (HP:0002101)1.77889620
124X-linked dominant inheritance (HP:0001423)1.77773093
125Aplasia/hypoplasia of the uterus (HP:0008684)1.77427842
126Abnormality of the hip-girdle musculature (HP:0001445)1.77024065
127Abnormality of the musculature of the pelvis (HP:0001469)1.77024065
128Hip dysplasia (HP:0001385)1.76845967
129Neoplasm of the pancreas (HP:0002894)1.76614171
130Thyroid carcinoma (HP:0002890)1.75301343
131Poor coordination (HP:0002370)1.75046270
132Progressive inability to walk (HP:0002505)1.75012667
133Hypoplastic pelvis (HP:0008839)1.73800794
134Unsteady gait (HP:0002317)1.72519378
135Posterior subcapsular cataract (HP:0007787)1.72282352
13611 pairs of ribs (HP:0000878)1.72268266
137Postaxial foot polydactyly (HP:0001830)1.71547266
138Papillary thyroid carcinoma (HP:0002895)1.70818840
139Abnormality of macular pigmentation (HP:0008002)1.70751878
140Abnormality of cells of the erythroid lineage (HP:0012130)1.69605438
141Glossoptosis (HP:0000162)1.69445270
142Muscular hypotonia of the trunk (HP:0008936)1.69366889
143Palpitations (HP:0001962)1.69336820
144Microretrognathia (HP:0000308)1.69048051
145Pachygyria (HP:0001302)1.68698991
146Aplasia/Hypoplasia of the lens (HP:0008063)1.68318535
147Abnormal number of erythroid precursors (HP:0012131)1.68310476
148Poor suck (HP:0002033)1.67504467
149Leukodystrophy (HP:0002415)1.66855768
150Shoulder girdle muscle weakness (HP:0003547)1.64843328
151Carpal bone hypoplasia (HP:0001498)1.64661456
152Reduced antithrombin III activity (HP:0001976)1.63711349
153Emotional lability (HP:0000712)1.62037558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.94637951
2MAP4K23.76345912
3STK163.54226217
4LIMK13.52365310
5EIF2AK13.27324685
6ACVR1B3.17050919
7MAP3K122.96071337
8BCR2.72093945
9BUB12.71004496
10PBK2.68030042
11DYRK22.66111836
12ERBB32.65494465
13TESK22.62997080
14MAP2K72.43924556
15CSNK1G22.35767978
16SRPK12.28288807
17TESK12.26338444
18SIK32.26134824
19MAP3K42.24149453
20ARAF2.14004506
21BMPR1B2.13634524
22PIM22.09894343
23BCKDK1.99724328
24BRAF1.78609146
25EIF2AK31.69954371
26DYRK31.65646814
27VRK11.64293848
28CCNB11.63500004
29WEE11.57077840
30NME11.51334911
31MKNK11.50126396
32CDK81.49932007
33CDC71.48163382
34BRSK21.44882844
35MARK11.43362684
36CASK1.41847157
37ADRBK21.35976408
38KSR11.31253304
39PINK11.28155741
40TGFBR11.27184593
41NME21.21171095
42NUAK11.18199980
43PLK31.13529977
44WNK31.13346977
45MAPK131.13015311
46EPHA31.12901857
47OXSR11.09973265
48VRK21.09912212
49MYLK1.09281458
50UHMK11.05339311
51SCYL21.04359303
52BRSK11.03319654
53NEK10.99877884
54PASK0.97734254
55AURKA0.97713118
56FRK0.97052762
57YES10.92316499
58PDK20.92283749
59TLK10.91808163
60MAP3K110.91410281
61FER0.91116670
62MINK10.87294438
63PRKCE0.84925477
64MAP3K50.84575334
65CSNK1G30.83545138
66GRK10.83445085
67IRAK20.82628547
68ILK0.80542284
69LMTK20.80536603
70EPHB20.78325799
71RPS6KA40.77740032
72MET0.76453364
73PLK10.72208829
74STK390.71103506
75MST40.67304674
76CDK190.66568875
77PLK20.65487025
78MKNK20.65381654
79AURKB0.63646828
80CDK140.62365409
81TAOK30.61622077
82INSRR0.61039687
83RAF10.60642606
84KDR0.60376079
85MAP3K90.60265511
86TSSK60.60167234
87MAPKAPK30.58530874
88PRKCG0.58456375
89WNK40.58333615
90DYRK1A0.58316147
91PAK10.57587635
92PAK30.57023118
93TAOK20.56975939
94RPS6KA50.56347321
95PLK40.56001115
96CDK70.55541883
97PRKCI0.55410806
98OBSCN0.54688126
99CAMK2A0.54616006
100DYRK1B0.54603596
101CDK180.52497948
102CSNK2A10.52443855
103CHEK20.52313500
104ABL20.50792978
105MAP2K10.49356953
106ZAK0.48583487
107PRPF4B0.47362516
108CAMKK20.45718477
109MAP2K40.45317476
110PAK40.43968435
111STK38L0.42551268
112ATR0.41894035
113ADRBK10.40254397
114GRK70.38973236
115IRAK40.38852968
116MAP2K20.38102730
117CSNK1G10.37808771
118STK240.37694054
119TTK0.37526372
120MUSK0.36753292
121MAPKAPK20.36131104
122PTK2B0.34231762
123CSNK1A10.34018229
124CDK11A0.33572368
125CDK150.33043773
126EIF2AK20.32858936
127EGFR0.32505230
128PRKACA0.32009192
129DAPK10.31957252
130CAMK2G0.31851440
131ERBB40.31341648
132IRAK10.30095734
133PHKG10.29892368
134PHKG20.29892368
135CAMK2D0.29236983
136DAPK20.29105733
137ERBB20.28949952
138CSNK2A20.28741832
139MAPK150.27816367
140CSNK1A1L0.27272203
141RPS6KA20.26727645

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.10841644
2DNA replication_Homo sapiens_hsa030303.45919583
3Protein export_Homo sapiens_hsa030603.29459946
4Oxidative phosphorylation_Homo sapiens_hsa001903.24660052
5RNA polymerase_Homo sapiens_hsa030202.98755345
6Parkinsons disease_Homo sapiens_hsa050122.98665563
7Mismatch repair_Homo sapiens_hsa034302.90902716
8Ribosome_Homo sapiens_hsa030102.74523170
9Spliceosome_Homo sapiens_hsa030402.67838633
10Base excision repair_Homo sapiens_hsa034102.50950388
11Pyrimidine metabolism_Homo sapiens_hsa002402.27693617
12Propanoate metabolism_Homo sapiens_hsa006402.24150589
13Huntingtons disease_Homo sapiens_hsa050162.22872685
14Nucleotide excision repair_Homo sapiens_hsa034202.21372768
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.15748481
16Cell cycle_Homo sapiens_hsa041102.01607317
17Homologous recombination_Homo sapiens_hsa034402.00992448
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83028328
19Basal transcription factors_Homo sapiens_hsa030221.82242416
20Alzheimers disease_Homo sapiens_hsa050101.81888791
21RNA transport_Homo sapiens_hsa030131.79127553
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75885825
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75737722
24Vibrio cholerae infection_Homo sapiens_hsa051101.69258996
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65683407
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60441031
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57484260
28Peroxisome_Homo sapiens_hsa041461.54820254
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54682862
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53306937
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.52957049
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51521642
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49424744
34RNA degradation_Homo sapiens_hsa030181.46047737
35Sulfur metabolism_Homo sapiens_hsa009201.41299781
36Phototransduction_Homo sapiens_hsa047441.40213080
37Butanoate metabolism_Homo sapiens_hsa006501.36632016
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33976876
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30380251
40Purine metabolism_Homo sapiens_hsa002301.28050256
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.16520538
42Collecting duct acid secretion_Homo sapiens_hsa049661.15032783
43Fanconi anemia pathway_Homo sapiens_hsa034601.14054380
44Pyruvate metabolism_Homo sapiens_hsa006201.10710114
45Phagosome_Homo sapiens_hsa041451.08055524
46Epstein-Barr virus infection_Homo sapiens_hsa051691.04205408
47Carbon metabolism_Homo sapiens_hsa012001.01568775
48Cardiac muscle contraction_Homo sapiens_hsa042600.98746750
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94756235
50Nicotine addiction_Homo sapiens_hsa050330.92799949
51N-Glycan biosynthesis_Homo sapiens_hsa005100.90830733
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89564924
53Non-homologous end-joining_Homo sapiens_hsa034500.88650108
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88644268
55Fatty acid metabolism_Homo sapiens_hsa012120.87444431
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87330676
57Shigellosis_Homo sapiens_hsa051310.85165170
58Folate biosynthesis_Homo sapiens_hsa007900.84381053
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83635329
60Oocyte meiosis_Homo sapiens_hsa041140.81419463
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80509993
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79214915
63Caffeine metabolism_Homo sapiens_hsa002320.78840497
64beta-Alanine metabolism_Homo sapiens_hsa004100.78205918
65mRNA surveillance pathway_Homo sapiens_hsa030150.78081120
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75895965
67Glutathione metabolism_Homo sapiens_hsa004800.74082435
68Arginine and proline metabolism_Homo sapiens_hsa003300.73130760
69Biosynthesis of amino acids_Homo sapiens_hsa012300.72892357
70Legionellosis_Homo sapiens_hsa051340.72013236
71Synaptic vesicle cycle_Homo sapiens_hsa047210.71534525
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71412976
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69898903
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.69834272
75p53 signaling pathway_Homo sapiens_hsa041150.69097934
76Chemical carcinogenesis_Homo sapiens_hsa052040.66025155
77GABAergic synapse_Homo sapiens_hsa047270.65574510
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65069927
79Thyroid cancer_Homo sapiens_hsa052160.60839761
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.60683725
81Rheumatoid arthritis_Homo sapiens_hsa053230.60084050
82Arachidonic acid metabolism_Homo sapiens_hsa005900.58178683
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55365109
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54359270
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54282438
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54198803
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.53470406
88Tryptophan metabolism_Homo sapiens_hsa003800.52782363
89Regulation of autophagy_Homo sapiens_hsa041400.52613946
90Retinol metabolism_Homo sapiens_hsa008300.52408531
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51839834
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51454530
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50016345
94Hippo signaling pathway_Homo sapiens_hsa043900.49901315
95TGF-beta signaling pathway_Homo sapiens_hsa043500.49258437
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48518281
97Phenylalanine metabolism_Homo sapiens_hsa003600.48210580
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47888846
99Sulfur relay system_Homo sapiens_hsa041220.47606508
100Alcoholism_Homo sapiens_hsa050340.44459569
101Colorectal cancer_Homo sapiens_hsa052100.43953307
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42527891
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41666827
104Hedgehog signaling pathway_Homo sapiens_hsa043400.40455219
105Salmonella infection_Homo sapiens_hsa051320.40004627
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38479425
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.37745087
108Metabolic pathways_Homo sapiens_hsa011000.37492103
109Axon guidance_Homo sapiens_hsa043600.37390060
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35565665
111Tyrosine metabolism_Homo sapiens_hsa003500.35388076
112Serotonergic synapse_Homo sapiens_hsa047260.34593766
113Basal cell carcinoma_Homo sapiens_hsa052170.34552795
114Fatty acid degradation_Homo sapiens_hsa000710.32155030
115One carbon pool by folate_Homo sapiens_hsa006700.29547565
116Steroid biosynthesis_Homo sapiens_hsa001000.28780568
117Fatty acid elongation_Homo sapiens_hsa000620.28598148
118Galactose metabolism_Homo sapiens_hsa000520.28581666
119Selenocompound metabolism_Homo sapiens_hsa004500.27427379
120Ether lipid metabolism_Homo sapiens_hsa005650.27214851
121HTLV-I infection_Homo sapiens_hsa051660.24348092
122Melanoma_Homo sapiens_hsa052180.22442066
123Pertussis_Homo sapiens_hsa051330.21898848
124Viral carcinogenesis_Homo sapiens_hsa052030.21818650
125Tight junction_Homo sapiens_hsa045300.20838933
126Linoleic acid metabolism_Homo sapiens_hsa005910.19590124
127Apoptosis_Homo sapiens_hsa042100.18960880
128Bladder cancer_Homo sapiens_hsa052190.18810363
129Viral myocarditis_Homo sapiens_hsa054160.17875780
130Asthma_Homo sapiens_hsa053100.16698661
131Herpes simplex infection_Homo sapiens_hsa051680.16201269
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14937800
133Circadian rhythm_Homo sapiens_hsa047100.13860820
134Sphingolipid metabolism_Homo sapiens_hsa006000.13731053
135Type I diabetes mellitus_Homo sapiens_hsa049400.13681401
136Pentose phosphate pathway_Homo sapiens_hsa000300.13588772
137Autoimmune thyroid disease_Homo sapiens_hsa053200.13488545
138Wnt signaling pathway_Homo sapiens_hsa043100.10603340
139Pathways in cancer_Homo sapiens_hsa052000.09958372
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09793215
141Other glycan degradation_Homo sapiens_hsa005110.09603832

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