TSGA10IP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.90578791
2binding of sperm to zona pellucida (GO:0007339)9.77548958
3multicellular organism reproduction (GO:0032504)9.71537778
4cell-cell recognition (GO:0009988)9.22523467
5acrosome assembly (GO:0001675)9.15434941
6spermatid development (GO:0007286)8.40616923
7reproduction (GO:0000003)8.29206336
8motile cilium assembly (GO:0044458)8.16733911
9axonemal dynein complex assembly (GO:0070286)8.08259987
10epithelial cilium movement (GO:0003351)8.05631278
11piRNA metabolic process (GO:0034587)8.01212257
12positive regulation of synaptic transmission, dopaminergic (GO:0032226)7.88401419
13plasma membrane fusion (GO:0045026)7.79677622
14protein-DNA complex disassembly (GO:0032986)7.62509460
15nucleosome disassembly (GO:0006337)7.62509460
16male meiosis (GO:0007140)6.87419651
17regulation of cilium movement (GO:0003352)6.81966000
18cilium movement (GO:0003341)6.75863873
19cilium or flagellum-dependent cell motility (GO:0001539)6.74534301
20single fertilization (GO:0007338)6.56992435
21synaptonemal complex organization (GO:0070193)6.56600810
22synaptonemal complex assembly (GO:0007130)6.54359419
23heterochromatin organization (GO:0070828)6.49824283
24regulation of phosphoprotein phosphatase activity (GO:0043666)6.42140537
25sperm capacitation (GO:0048240)6.17065034
26spermatogenesis (GO:0007283)6.11084285
27male gamete generation (GO:0048232)6.09110218
28negative regulation of inclusion body assembly (GO:0090084)6.08819644
29positive regulation of catecholamine secretion (GO:0033605)6.03600508
30microtubule depolymerization (GO:0007019)5.93099621
31fertilization (GO:0009566)5.92787434
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.87237669
33gamete generation (GO:0007276)5.69564066
34DNA methylation involved in gamete generation (GO:0043046)5.63341472
35organic cation transport (GO:0015695)5.56530121
36chromosome condensation (GO:0030261)5.51217278
37regulation of oxidative stress-induced neuron death (GO:1903203)5.49062709
38regulation of gene silencing by miRNA (GO:0060964)5.43320729
39regulation of gene silencing by RNA (GO:0060966)5.43320729
40regulation of posttranscriptional gene silencing (GO:0060147)5.43320729
41tongue development (GO:0043586)5.36012319
42regulation of inclusion body assembly (GO:0090083)5.15199695
43DNA packaging (GO:0006323)5.09239512
44germ cell development (GO:0007281)4.93366892
45L-serine metabolic process (GO:0006563)4.90857152
46seminiferous tubule development (GO:0072520)4.89730972
47paraxial mesoderm development (GO:0048339)4.83034127
48cellular process involved in reproduction in multicellular organism (GO:0022412)4.77101760
49exocrine pancreas development (GO:0031017)4.74875656
50regulation of oxidative phosphorylation (GO:0002082)4.72038529
51male meiosis I (GO:0007141)4.63986274
52ribosomal small subunit assembly (GO:0000028)4.61676148
53microtubule severing (GO:0051013)4.47157129
54multicellular organismal reproductive process (GO:0048609)4.46435006
55glycerol ether metabolic process (GO:0006662)4.42549087
56activation of protein kinase B activity (GO:0032148)4.41066881
57chromosome organization involved in meiosis (GO:0070192)4.38496376
58ribosomal small subunit biogenesis (GO:0042274)4.28140529
59meiotic cell cycle (GO:0051321)4.24075474
60viral transcription (GO:0019083)4.21601962
61regulation of cellular respiration (GO:0043457)4.20380596
62intestinal cholesterol absorption (GO:0030299)4.19346150
63meiotic nuclear division (GO:0007126)4.19317138
64cell recognition (GO:0008037)4.17758343
65calcium ion-dependent exocytosis (GO:0017156)4.16368927
66ether metabolic process (GO:0018904)4.06122167
67translational termination (GO:0006415)4.00250160
68pre-miRNA processing (GO:0031054)3.99856134
69digestion (GO:0007586)3.85248118
70regulation of spindle checkpoint (GO:0090231)3.84757673
71regulation of microtubule-based movement (GO:0060632)3.84275937
72negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.80194387
73single strand break repair (GO:0000012)3.79657016
74glutamine family amino acid catabolic process (GO:0009065)3.79209085
75synapsis (GO:0007129)3.78480471
76positive regulation of SMAD protein import into nucleus (GO:0060391)3.76761569
77TOR signaling (GO:0031929)3.75817371
78meiosis I (GO:0007127)3.74059956
79chaperone-mediated protein complex assembly (GO:0051131)3.73194038
80maturation of SSU-rRNA (GO:0030490)3.67094582
81protein complex disassembly (GO:0043241)3.66264550
82ventricular system development (GO:0021591)3.65411426
83regulation of acrosome reaction (GO:0060046)3.61411537
84histone H3-K9 demethylation (GO:0033169)3.58957773
85multicellular organismal development (GO:0007275)3.57321004
86aspartate family amino acid catabolic process (GO:0009068)3.56734451
87spermatid nucleus differentiation (GO:0007289)3.55591559
88ATP-dependent chromatin remodeling (GO:0043044)3.54497568
89polyamine metabolic process (GO:0006595)3.54279767
90left/right pattern formation (GO:0060972)3.51555897
91DNA synthesis involved in DNA repair (GO:0000731)3.48779342
92regulation of hydrogen peroxide-induced cell death (GO:1903205)3.48652012
93negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.45153007
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.44212807
95cGMP-mediated signaling (GO:0019934)3.43527909
96protein polyglutamylation (GO:0018095)3.41350272
97DNA deamination (GO:0045006)3.41320891
98negative regulation of response to reactive oxygen species (GO:1901032)3.40431098
99protein retention in ER lumen (GO:0006621)3.40184836
100sequestering of actin monomers (GO:0042989)3.39045705
101negative regulation of microtubule polymerization (GO:0031115)3.38359691
102Leydig cell differentiation (GO:0033327)3.36437028
103macromolecular complex disassembly (GO:0032984)3.35783323
104proline biosynthetic process (GO:0006561)3.35460059
105regulation of autophagic vacuole assembly (GO:2000785)3.34851286
106translational elongation (GO:0006414)3.34811043
107male sex determination (GO:0030238)3.34806329
108protein polymerization (GO:0051258)3.34108409
109cellular biogenic amine biosynthetic process (GO:0042401)3.33364622
110DNA damage response, detection of DNA damage (GO:0042769)3.32725888
111relaxation of smooth muscle (GO:0044557)3.31504963
112sexual reproduction (GO:0019953)3.31046291
113amine biosynthetic process (GO:0009309)3.25783704
114histone arginine methylation (GO:0034969)3.22904689
115potassium ion export (GO:0071435)3.22710715
116telomere maintenance via semi-conservative replication (GO:0032201)3.21220034
117negative regulation of translational initiation (GO:0045947)3.21063918
118GTP biosynthetic process (GO:0006183)3.19631500
119interferon-gamma secretion (GO:0072643)3.18136650
120serine family amino acid catabolic process (GO:0009071)3.15905364
121translational initiation (GO:0006413)3.15689462
122DNA strand elongation involved in DNA replication (GO:0006271)3.14531255
123viral life cycle (GO:0019058)3.12451852
124cellular protein complex disassembly (GO:0043624)3.11299574
125meiotic cell cycle process (GO:1903046)3.10650884
126SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10118174
127glycogen metabolic process (GO:0005977)3.10021769
128chromatin assembly (GO:0031497)3.07379806
129GDP-mannose metabolic process (GO:0019673)3.07301767
130protein targeting to ER (GO:0045047)3.07136072
131cellular glucan metabolic process (GO:0006073)3.05086302
132glucan metabolic process (GO:0044042)3.05086302
133maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.01783786
134gene silencing by RNA (GO:0031047)3.01218515
135microtubule polymerization or depolymerization (GO:0031109)3.00821462
136cotranslational protein targeting to membrane (GO:0006613)2.99995094
137nucleoside diphosphate phosphorylation (GO:0006165)2.99364510
138lung-associated mesenchyme development (GO:0060484)2.96704767
139peptidyl-proline hydroxylation (GO:0019511)2.95986500
140negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.95641280
141polyamine biosynthetic process (GO:0006596)2.95572112
142UTP biosynthetic process (GO:0006228)2.94388097
143DNA strand elongation (GO:0022616)2.93261536
144DNA integration (GO:0015074)2.91284027
145protein localization to chromosome, centromeric region (GO:0071459)2.89175806
146establishment of integrated proviral latency (GO:0075713)2.88159803
147regulation of gene silencing (GO:0060968)2.87917847
148protein localization to endoplasmic reticulum (GO:0070972)2.87863346
149negative regulation of androgen receptor signaling pathway (GO:0060766)2.86478373
150establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86478319
151histone H3-K36 demethylation (GO:0070544)2.86415713
152regulation of female gonad development (GO:2000194)2.85533973
153DNA double-strand break processing (GO:0000729)2.85434840
154regulation of vacuole organization (GO:0044088)2.81751190
155UTP metabolic process (GO:0046051)2.81688804
156cell redox homeostasis (GO:0045454)2.80836824
157telomere maintenance (GO:0000723)2.79152430
158gene silencing (GO:0016458)2.79078594
159positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.78368007
160chromatin silencing (GO:0006342)2.75263701
161histone exchange (GO:0043486)2.72192039
162cobalamin metabolic process (GO:0009235)2.71631769
163genitalia morphogenesis (GO:0035112)2.70699244
164DNA methylation (GO:0006306)2.63570064
165DNA alkylation (GO:0006305)2.63570064
166mitotic sister chromatid cohesion (GO:0007064)2.63321165
167protein refolding (GO:0042026)2.59573067
168guanosine-containing compound biosynthetic process (GO:1901070)2.57929070
169regulation of cilium assembly (GO:1902017)2.53348575
170nucleus organization (GO:0006997)2.52503161
171protein localization to cilium (GO:0061512)2.50364832
172cholesterol catabolic process (GO:0006707)2.49797677
173sterol catabolic process (GO:0016127)2.49797677
174protein complex localization (GO:0031503)2.47965021
175sperm motility (GO:0030317)11.5084721
176fusion of sperm to egg plasma membrane (GO:0007342)10.3762270
177sperm-egg recognition (GO:0035036)10.3495918
178cell wall macromolecule catabolic process (GO:0016998)10.3037332
179cell wall macromolecule metabolic process (GO:0044036)10.3037332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.65044305
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.67933573
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.24844802
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.92143785
5EZH2_22144423_ChIP-Seq_EOC_Human3.51696041
6E2F7_22180533_ChIP-Seq_HELA_Human3.04865787
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.86398577
8GATA1_26923725_Chip-Seq_HPCs_Mouse2.60351336
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60081188
10IGF1R_20145208_ChIP-Seq_DFB_Human2.53707462
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50574552
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46043153
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.41703676
14VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.34638448
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.28087246
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24940121
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23420800
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22778930
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15931140
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13790926
21SOX2_18555785_ChIP-Seq_MESCs_Mouse2.10698206
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03135607
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03135607
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03135607
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97089157
26SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.95784519
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95088936
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94617568
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88765068
30SOX2_22085726_ChIP-Seq_NPCs_Mouse1.87652844
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83751266
32GATA3_21867929_ChIP-Seq_CD8_Mouse1.80214956
33XRN2_22483619_ChIP-Seq_HELA_Human1.76972628
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75476797
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74058635
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73778153
37P53_21459846_ChIP-Seq_SAOS-2_Human1.68683348
38STAT1_17558387_ChIP-Seq_HELA_Human1.68269153
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.65881674
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.63857323
41ZNF274_21170338_ChIP-Seq_K562_Hela1.59021239
42ESET_19884257_ChIP-Seq_ESCs_Mouse1.57829798
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54972514
44FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.54670773
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54266700
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53604343
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.52978669
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52521424
49SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52403622
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.52236196
51KAP1_22055183_ChIP-Seq_ESCs_Mouse1.51681452
52* CTCF_27219007_Chip-Seq_Bcells_Human1.51562001
53FOXP3_21729870_ChIP-Seq_TREG_Human1.50042422
54IRF1_19129219_ChIP-ChIP_H3396_Human1.48915260
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48687211
56* ERG_20517297_ChIP-Seq_VCAP_Human1.48194311
57CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47692670
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47103621
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.47061208
60SMC4_20622854_ChIP-Seq_HELA_Human1.46519125
61RXRA_24833708_ChIP-Seq_LIVER_Mouse1.45124218
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44222375
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.43977888
64SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.43287860
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.42918973
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.40609427
67LXR_22292898_ChIP-Seq_THP-1_Human1.40423867
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40293847
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39547572
70GABP_19822575_ChIP-Seq_HepG2_Human1.38969608
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.38760981
72P68_20966046_ChIP-Seq_HELA_Human1.38167087
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38163699
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36726739
75TTF2_22483619_ChIP-Seq_HELA_Human1.34971280
76CTCF_26484167_Chip-Seq_Bcells_Mouse1.34868319
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31898518
78SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30622036
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.28440307
80BCOR_27268052_Chip-Seq_Bcells_Human1.27428735
81LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.26573544
82GATA3_21867929_ChIP-Seq_TH1_Mouse1.26511928
83NANOG_20526341_ChIP-Seq_ESCs_Human1.25306648
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25007295
85NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24518994
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.24378087
87SPI1_26923725_Chip-Seq_HPCs_Mouse1.24173420
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.23714513
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22464659
90TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21622681
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21110177
92RARA_24833708_ChIP-Seq_LIVER_Mouse1.20757498
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20706355
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18698008
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18264821
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17860826
97FLI1_21867929_ChIP-Seq_CD8_Mouse1.17822618
98JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.17571015
99RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17442444
100FOXP1_21924763_ChIP-Seq_HESCs_Human1.17368841
101MYC_18940864_ChIP-ChIP_HL60_Human1.16471383
102TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16255096
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15817704
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15726274
105VDR_22108803_ChIP-Seq_LS180_Human1.15532249
106OCT4_20526341_ChIP-Seq_ESCs_Human1.14246641
107SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13446814
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13364886
109LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.13006457
110CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12867651
111SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12809931
112CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12190042
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11866830
114CTCF_20526341_ChIP-Seq_ESCs_Human1.11684313
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.11602608
116MAF_26560356_Chip-Seq_TH2_Human1.11224724
117ERA_21632823_ChIP-Seq_H3396_Human1.11118110
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10572247
119SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10152241
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09951268
121GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.09592490
122GF1_26923725_Chip-Seq_HPCs_Mouse1.09098513
123NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09055852
124SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08550128
125RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08500716
126BCL6_27268052_Chip-Seq_Bcells_Human1.08014755
127SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06157574
128WDR5_24793694_ChIP-Seq_LNCAP_Human1.05947309
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05909338
130SOX2_16153702_ChIP-ChIP_HESCs_Human1.05532425
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04895923
132FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04724430
133ELF1_20517297_ChIP-Seq_JURKAT_Human1.04007887
134TAL1_26923725_Chip-Seq_HPCs_Mouse1.03858623
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03852494
136RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03768772
137VDR_21846776_ChIP-Seq_THP-1_Human1.03230863
138PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02924630
139PHF8_20622854_ChIP-Seq_HELA_Human1.02467127
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02454623
141MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02431661
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02146487
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01824143
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01618719
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00491394
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00491394
147STAT1_20625510_ChIP-Seq_HELA_Human1.00394334
148TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00211503
149SPI1_20517297_ChIP-Seq_HL60_Human1.00010712
150MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99623635
151CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99582888
152MYC_27129775_Chip-Seq_CORNEA_Mouse0.99422258
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98987810
154PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98700854
155TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98568771
156GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98538094
157RAC3_21632823_ChIP-Seq_H3396_Human0.98378247
158ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96960051
159MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96716662
160ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96693051
161EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96498293
162CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96089439
163GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95960576
164KDM2B_26808549_Chip-Seq_DND41_Human0.95608357
165KDM2B_26808549_Chip-Seq_REH_Human0.95518746
166PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93670174
167ETS1_21867929_ChIP-Seq_TH2_Mouse0.93387810
168GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93321392
169CTCF_21964334_Chip-Seq_Bcells_Human0.92818589
170SOX2_21211035_ChIP-Seq_LN229_Human0.92387144
171PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92258122
172PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91491089
173RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91415084
174MYC_18555785_ChIP-Seq_MESCs_Mouse0.91281477
175NFE2_27457419_Chip-Seq_LIVER_Mouse0.90770236
176AR_21909140_ChIP-Seq_LNCAP_Human0.90705048
177TP63_22573176_ChIP-Seq_HFKS_Human0.90677998
178MYC_19829295_ChIP-Seq_ESCs_Human0.90659639
179DCP1A_22483619_ChIP-Seq_HELA_Human0.90611894
180NFYB_21822215_ChIP-Seq_K562_Human0.90143447
181NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89356146
182CBP_20019798_ChIP-Seq_JUKART_Human0.88334536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001929_abnormal_gametogenesis5.29484549
2MP0003698_abnormal_male_reproductive5.17197129
3MP0005083_abnormal_biliary_tract3.78796049
4MP0008877_abnormal_DNA_methylation3.77939104
5MP0003136_yellow_coat_color3.64672047
6MP0008004_abnormal_stomach_pH3.63484856
7MP0001666_abnormal_nutrient_absorption3.46788962
8MP0002210_abnormal_sex_determination3.34240389
9MP0002254_reproductive_system_inflammat3.27027356
10MP0010030_abnormal_orbit_morphology3.22770574
11MP0002161_abnormal_fertility/fecundity3.08228994
12MP0005220_abnormal_exocrine_pancreas2.90916893
13MP0001145_abnormal_male_reproductive2.81209669
14MP0005365_abnormal_bile_salt2.78643103
15MP0005499_abnormal_olfactory_system2.78129870
16MP0005394_taste/olfaction_phenotype2.78129870
17MP0006292_abnormal_olfactory_placode2.72548859
18MP0000537_abnormal_urethra_morphology2.68914591
19MP0000653_abnormal_sex_gland2.64475349
20MP0005670_abnormal_white_adipose2.54096206
21MP0003878_abnormal_ear_physiology2.52649218
22MP0005377_hearing/vestibular/ear_phenot2.52649218
23MP0005058_abnormal_lysosome_morphology2.29309446
24MP0009379_abnormal_foot_pigmentation2.25946096
25MP0003718_maternal_effect2.17573869
26MP0005084_abnormal_gallbladder_morpholo2.02292917
27MP0005410_abnormal_fertilization13.0523039
28MP0000566_synostosis1.99653521
29MP0001849_ear_inflammation1.82751709
30MP0003868_abnormal_feces_composition1.79946462
31MP0008789_abnormal_olfactory_epithelium1.79753983
32MP0005645_abnormal_hypothalamus_physiol1.78444068
33MP0003646_muscle_fatigue1.78104650
34MP0001984_abnormal_olfaction1.66854653
35MP0003693_abnormal_embryo_hatching1.65627751
36MP0004233_abnormal_muscle_weight1.59175090
37MP0002653_abnormal_ependyma_morphology1.58906043
38MP0003890_abnormal_embryonic-extraembry1.58209827
39MP0002139_abnormal_hepatobiliary_system1.58039253
40MP0001529_abnormal_vocalization1.54457994
41MP0004957_abnormal_blastocyst_morpholog1.49046717
42MP0005085_abnormal_gallbladder_physiolo1.49004939
43MP0002132_abnormal_respiratory_system1.48181169
44MP0005451_abnormal_body_composition1.45836122
45MP0005187_abnormal_penis_morphology1.44579904
46MP0010094_abnormal_chromosome_stability1.38192789
47MP0005174_abnormal_tail_pigmentation1.37617343
48MP0002160_abnormal_reproductive_system1.36093184
49MP0002090_abnormal_vision1.36044344
50MP0008058_abnormal_DNA_repair1.29681161
51MP0009672_abnormal_birth_weight1.28534795
52MP0000049_abnormal_middle_ear1.27054570
53MP0002693_abnormal_pancreas_physiology1.26766544
54MP0003111_abnormal_nucleus_morphology1.25362036
55MP0002233_abnormal_nose_morphology1.21031800
56MP0003938_abnormal_ear_development1.17866613
57MP0003119_abnormal_digestive_system1.16418538
58MP0001664_abnormal_digestion1.15672045
59MP0002697_abnormal_eye_size1.15002991
60MP0003699_abnormal_female_reproductive1.13916765
61MP0002938_white_spotting1.12239318
62MP0002092_abnormal_eye_morphology1.10990210
63MP0003959_abnormal_lean_body1.07742778
64MP0001188_hyperpigmentation1.06283436
65MP0003121_genomic_imprinting1.05621250
66MP0002111_abnormal_tail_morphology1.04298858
67MP0005389_reproductive_system_phenotype1.03424866
68MP0006036_abnormal_mitochondrial_physio1.02675396
69MP0005248_abnormal_Harderian_gland1.02526822
70MP0003077_abnormal_cell_cycle0.99795256
71MP0001905_abnormal_dopamine_level0.99543936
72MP0001764_abnormal_homeostasis0.97187702
73MP0005075_abnormal_melanosome_morpholog0.96352233
74MP0001119_abnormal_female_reproductive0.95347541
75MP0002234_abnormal_pharynx_morphology0.94894328
76MP0003937_abnormal_limbs/digits/tail_de0.93595270
77MP0002751_abnormal_autonomic_nervous0.92354064
78MP0004264_abnormal_extraembryonic_tissu0.91761847
79MP0002282_abnormal_trachea_morphology0.89344076
80MP0003567_abnormal_fetal_cardiomyocyte0.89239322
81MP0000428_abnormal_craniofacial_morphol0.84900655
82MP0001485_abnormal_pinna_reflex0.84828663
83MP0001765_abnormal_ion_homeostasis0.84495863
84MP0005647_abnormal_sex_gland0.83402798
85MP0005391_vision/eye_phenotype0.83285733
86MP0003861_abnormal_nervous_system0.82531224
87MP0003936_abnormal_reproductive_system0.80248038
88MP0004197_abnormal_fetal_growth/weight/0.79228954
89MP0003122_maternal_imprinting0.77935621
90MP0001873_stomach_inflammation0.77251722
91MP0001286_abnormal_eye_development0.74936644
92MP0003763_abnormal_thymus_physiology0.74861820
93MP0005395_other_phenotype0.74307520
94MP0004858_abnormal_nervous_system0.73780516
95MP0000490_abnormal_crypts_of0.70966955
96MP0006072_abnormal_retinal_apoptosis0.68817556
97MP0000631_abnormal_neuroendocrine_gland0.68772029
98MP0005636_abnormal_mineral_homeostasis0.68317546
99MP0000751_myopathy0.66381898
100MP0001944_abnormal_pancreas_morphology0.66101747
101MP0001545_abnormal_hematopoietic_system0.65564938
102MP0005397_hematopoietic_system_phenotyp0.65564938
103MP0001299_abnormal_eye_distance/0.63310891
104MP0001853_heart_inflammation0.63225923
105MP0001502_abnormal_circadian_rhythm0.62782273
106MP0004808_abnormal_hematopoietic_stem0.60469239
107MP0004381_abnormal_hair_follicle0.60433721
108MP0000358_abnormal_cell_content/0.60429155
109MP0009278_abnormal_bone_marrow0.60236408
110MP0003315_abnormal_perineum_morphology0.59762291
111MP0008932_abnormal_embryonic_tissue0.59021730
112MP0000432_abnormal_head_morphology0.58894442
113MP0003755_abnormal_palate_morphology0.58850825
114MP0003186_abnormal_redox_activity0.58164439
115MP0003828_pulmonary_edema0.58048441
116MP0001730_embryonic_growth_arrest0.57851399
117MP0004133_heterotaxia0.54658418
118MP0002277_abnormal_respiratory_mucosa0.54048395
119MP0008995_early_reproductive_senescence0.53270415
120MP0001672_abnormal_embryogenesis/_devel0.52518453
121MP0005380_embryogenesis_phenotype0.52518453
122MP0001919_abnormal_reproductive_system0.52305113
123MP0003806_abnormal_nucleotide_metabolis0.51977183
124MP0002736_abnormal_nociception_after0.51471339
125MP0000313_abnormal_cell_death0.50352772
126MP0002249_abnormal_larynx_morphology0.49930031
127MP0008057_abnormal_DNA_replication0.49470342
128MP0005408_hypopigmentation0.47998487
129MP0003638_abnormal_response/metabolism_0.44749368
130MP0005332_abnormal_amino_acid0.44730874
131MP0000613_abnormal_salivary_gland0.44497087
132MP0003011_delayed_dark_adaptation0.43815648
133MP0002269_muscular_atrophy0.43667025
134MP0003786_premature_aging0.42690193
135MP0006035_abnormal_mitochondrial_morpho0.42452050
136MP0009697_abnormal_copulation0.42076223
137MP0003115_abnormal_respiratory_system0.41388248
138MP0001697_abnormal_embryo_size0.41187871
139MP0002084_abnormal_developmental_patter0.40077762
140MP0001293_anophthalmia0.39986039
141MP0002118_abnormal_lipid_homeostasis0.39680617
142MP0008872_abnormal_physiological_respon0.39614768
143MP0009333_abnormal_splenocyte_physiolog0.38998810
144MP0000470_abnormal_stomach_morphology0.38513368
145MP0002080_prenatal_lethality0.38163275
146MP0002932_abnormal_joint_morphology0.37432422
147MP0002638_abnormal_pupillary_reflex0.36387083
148MP0002085_abnormal_embryonic_tissue0.35409125
149MP0002169_no_abnormal_phenotype0.35336425
150MP0002873_normal_phenotype0.34770809
151MP0005623_abnormal_meninges_morphology0.34278216
152MP0005360_urolithiasis0.32481341
153MP0009643_abnormal_urine_homeostasis0.31969498
154MP0002405_respiratory_system_inflammati0.31679581
155MP0005165_increased_susceptibility_to0.30797485
156MP0005319_abnormal_enzyme/_coenzyme0.30561144
157MP0005666_abnormal_adipose_tissue0.29677225
158MP0003123_paternal_imprinting0.29105027
159MP0002928_abnormal_bile_duct0.28947283

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.07936517
2Abnormal respiratory epithelium morphology (HP:0012253)8.05507785
3Abnormal respiratory motile cilium morphology (HP:0005938)8.05507785
4Chronic bronchitis (HP:0004469)7.29511913
5Abnormal ciliary motility (HP:0012262)7.24252197
6Infertility (HP:0000789)7.13608652
7Rhinitis (HP:0012384)7.02656938
8Septo-optic dysplasia (HP:0100842)6.26132525
9Nasal polyposis (HP:0100582)5.90826184
10Sex reversal (HP:0012245)5.36566928
11Abnormal sex determination (HP:0012244)5.36566928
12Male infertility (HP:0003251)5.28302418
13Abnormality of the nasal mucosa (HP:0000433)4.80641813
14Bronchiectasis (HP:0002110)4.78729988
15Reticulocytopenia (HP:0001896)4.64689769
16Abnormality of the columella (HP:0009929)4.49574606
17Hypoplasia of the uterus (HP:0000013)4.47659811
18Bronchitis (HP:0012387)4.31640382
19Resting tremor (HP:0002322)4.04329402
20Facial hemangioma (HP:0000329)3.74658769
21Colitis (HP:0002583)3.72806625
22Thoracic kyphosis (HP:0002942)3.65962040
23Abnormal spermatogenesis (HP:0008669)3.65123840
24Nephronophthisis (HP:0000090)3.58381608
25Postural instability (HP:0002172)3.48458314
26Aplasia/hypoplasia of the uterus (HP:0008684)3.40873612
27High anterior hairline (HP:0009890)3.28140008
28Absent thumb (HP:0009777)3.27127805
29Duplication of thumb phalanx (HP:0009942)3.26434944
30Hepatoblastoma (HP:0002884)3.25676475
31Gonadal dysgenesis (HP:0000133)3.21998874
32Partial duplication of thumb phalanx (HP:0009944)3.18317803
33Tubulointerstitial nephritis (HP:0001970)3.13840753
34Aplasia/Hypoplasia of the sacrum (HP:0008517)3.11796953
35Reduced antithrombin III activity (HP:0001976)3.10103260
36Meckel diverticulum (HP:0002245)3.03041617
37Abnormality of the ileum (HP:0001549)3.01990530
38Absent septum pellucidum (HP:0001331)2.98972570
39Abnormality of the lumbar spine (HP:0100712)2.96523256
40Abnormality of DNA repair (HP:0003254)2.94383843
41Colon cancer (HP:0003003)2.92228779
42Abnormality of the renal medulla (HP:0100957)2.87002376
43Impulsivity (HP:0100710)2.82599858
44Gonadotropin excess (HP:0000837)2.79162171
45Centrally nucleated skeletal muscle fibers (HP:0003687)2.78272939
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.75299013
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.75299013
48Supernumerary spleens (HP:0009799)2.73432150
49Recurrent otitis media (HP:0000403)2.72262469
50Anosmia (HP:0000458)2.69178598
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.67078205
52Abnormality of midbrain morphology (HP:0002418)2.64830627
53Molar tooth sign on MRI (HP:0002419)2.64830627
54Lipid accumulation in hepatocytes (HP:0006561)2.64623955
55Gastrointestinal inflammation (HP:0004386)2.60655921
56Inflammation of the large intestine (HP:0002037)2.59962963
57Abnormal gallbladder physiology (HP:0012438)2.59715975
58Cholecystitis (HP:0001082)2.59715975
59Abnormality of the septum pellucidum (HP:0007375)2.59479328
60Hyperglycinemia (HP:0002154)2.59342182
61Partial duplication of the phalanx of hand (HP:0009999)2.54479730
62Recurrent sinusitis (HP:0011108)2.54428516
63Thoracolumbar scoliosis (HP:0002944)2.53764267
64Unilateral renal agenesis (HP:0000122)2.53717971
65Abnormality of the labia minora (HP:0012880)2.48157246
66Germ cell neoplasia (HP:0100728)2.46864589
67Tubular atrophy (HP:0000092)2.46203948
68Triphalangeal thumb (HP:0001199)2.42409177
69Cortical dysplasia (HP:0002539)2.40507750
70Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38599131
71Rib fusion (HP:0000902)2.38502100
72Absent radius (HP:0003974)2.38117448
73Male pseudohermaphroditism (HP:0000037)2.37999608
74Tubulointerstitial abnormality (HP:0001969)2.33918460
75Abnormality of the thoracic spine (HP:0100711)2.33729550
76Recurrent bronchitis (HP:0002837)2.33059361
77Ectopic kidney (HP:0000086)2.31111249
78Breast aplasia (HP:0100783)2.28606779
79Tubulointerstitial fibrosis (HP:0005576)2.28243682
80Protruding tongue (HP:0010808)2.27299520
81Rectovaginal fistula (HP:0000143)2.23942262
82Rectal fistula (HP:0100590)2.23942262
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.23670655
84Aplasia involving forearm bones (HP:0009822)2.21353562
85Absent forearm bone (HP:0003953)2.21353562
86Capillary hemangiomas (HP:0005306)2.19790844
87Premature ovarian failure (HP:0008209)2.16968881
88Cerebellar dysplasia (HP:0007033)2.16579394
89Abnormality of cells of the erythroid lineage (HP:0012130)2.15886340
90Vitreoretinal degeneration (HP:0000655)2.15781370
91Type 2 muscle fiber atrophy (HP:0003554)2.12905301
92Generalized hypotonia (HP:0001290)2.12030209
93Heterotopia (HP:0002282)2.11380480
94Vaginal fistula (HP:0004320)2.09855820
95Choanal stenosis (HP:0000452)2.08177973
96Short chin (HP:0000331)2.04903748
97Intestinal fistula (HP:0100819)2.04667019
98Horseshoe kidney (HP:0000085)2.04327150
99Aplasia/Hypoplasia of the breasts (HP:0010311)2.04207659
100Chromsome breakage (HP:0040012)2.01575775
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.8117171
102Absent/shortened dynein arms (HP:0200106)11.6758491
103Dynein arm defect of respiratory motile cilia (HP:0012255)11.6758491
104Morphological abnormality of the inner ear (HP:0011390)1.97719995
105Thrombocytosis (HP:0001894)1.97012063
106Primary amenorrhea (HP:0000786)1.96017388
107Hypogonadotrophic hypogonadism (HP:0000044)1.95470895
108Abnormal hair whorl (HP:0010721)1.95201422
109Abnormality of the renal cortex (HP:0011035)1.93832948
110Preaxial foot polydactyly (HP:0001841)1.92610743
111Broad thumb (HP:0011304)1.91954713
112Abnormality of the preputium (HP:0100587)1.89821571
113Abnormal number of erythroid precursors (HP:0012131)1.89795510
114Abdominal situs inversus (HP:0003363)1.89525159
115Abnormality of abdominal situs (HP:0011620)1.89525159
116Exercise-induced myalgia (HP:0003738)1.88273512
117Azoospermia (HP:0000027)1.88085087
118Rocker bottom foot (HP:0001838)1.87839225
119Enlarged kidneys (HP:0000105)1.85782070
120Hypoplastic pelvis (HP:0008839)1.84958341
121Turricephaly (HP:0000262)1.84932836
122Tracheoesophageal fistula (HP:0002575)1.84214674
123Abnormal hemoglobin (HP:0011902)1.81807492
124Decreased subcutaneous fat (HP:0001002)1.80584631
125Duplicated collecting system (HP:0000081)1.79849439
126Easy fatigability (HP:0003388)1.79740112
127Hyperglycinuria (HP:0003108)1.79003934
128Muscle fiber atrophy (HP:0100295)1.77891483
129Amyotrophic lateral sclerosis (HP:0007354)1.74823158
130Congenital malformation of the right heart (HP:0011723)1.74140190
131Double outlet right ventricle (HP:0001719)1.74140190
132Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74107003
133Steatorrhea (HP:0002570)1.72602055
134Abnormality of the lower motor neuron (HP:0002366)1.66798343
135Retinal dysplasia (HP:0007973)1.65683419
136Stage 5 chronic kidney disease (HP:0003774)1.62508307
137Optic nerve hypoplasia (HP:0000609)1.62494324
138Medial flaring of the eyebrow (HP:0010747)1.60933978
139Abnormality of subcutaneous fat tissue (HP:0001001)1.59839239
140Abnormality of renal excretion (HP:0011036)1.54569055
141Dyschromatopsia (HP:0007641)1.54287315
142Choroideremia (HP:0001139)1.52493423
143Abnormality of the phalanges of the hallux (HP:0010057)1.52472555
144Hypoplasia of the pons (HP:0012110)1.51706257
145Personality changes (HP:0000751)1.51237258
146Median cleft lip (HP:0000161)1.49383280
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.48426387
148Postaxial foot polydactyly (HP:0001830)1.47686718
149Carpal bone hypoplasia (HP:0001498)1.45396578
150Sloping forehead (HP:0000340)1.44346754
151Oculomotor apraxia (HP:0000657)1.41997916
152Progressive muscle weakness (HP:0003323)1.40458571
153Abnormal lung lobation (HP:0002101)1.40375626
154Abnormality of dentin (HP:0010299)1.37186612
155Fatigable weakness (HP:0003473)1.35786366
156Abnormality of the neuromuscular junction (HP:0003398)1.35786366
157Malnutrition (HP:0004395)1.34891170
158Type II lissencephaly (HP:0007260)1.34587472
159Abnormal ventriculo-arterial connection (HP:0011563)1.34308462
160Transposition of the great arteries (HP:0001669)1.34308462
161Abnormal connection of the cardiac segments (HP:0011545)1.34308462
162Abnormality of the pons (HP:0007361)1.34106336
163Gout (HP:0001997)1.33082840
164Facial cleft (HP:0002006)1.32914101
165Fat malabsorption (HP:0002630)1.32311610
166Impaired proprioception (HP:0010831)1.30839855
167Hemorrhage of the eye (HP:0011885)1.28472786
168Abnormality of cochlea (HP:0000375)1.25980198
169Congenital hepatic fibrosis (HP:0002612)1.25821512
170Postaxial hand polydactyly (HP:0001162)1.23975393
171Short tibia (HP:0005736)1.21783905
172Hypergonadotropic hypogonadism (HP:0000815)1.21636575
173Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.21530743
174Abnormal drinking behavior (HP:0030082)1.21476418
175Polydipsia (HP:0001959)1.21476418
176Renal dysplasia (HP:0000110)1.19880920
177Maternal diabetes (HP:0009800)1.18046972
178Long foot (HP:0001833)1.17357892
179Rhabdomyolysis (HP:0003201)1.16759127
180Polymicrogyria (HP:0002126)1.16750873
181Decreased central vision (HP:0007663)1.16565466
182Taurodontia (HP:0000679)1.16350770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.24565640
2PDK37.24565640
3TESK15.53869644
4ZAK5.32850830
5MARK34.70199504
6PDK24.68539883
7PRKD34.17077772
8ICK3.55843236
9VRK22.78223734
10TLK12.76480756
11BCKDK2.53993600
12NEK22.51509773
13RPS6KA52.47234688
14MYLK2.35264265
15WNK42.16606614
16STK392.15430111
17MAP3K102.14353753
18CDK191.94504423
19STK381.90311944
20SMG11.86013039
21EEF2K1.83948049
22MUSK1.78905289
23MAP2K71.65932047
24CSNK1A1L1.50904250
25TAF11.48581857
26PTK2B1.46356320
27CSNK1G31.42606743
28TTK1.39172561
29PINK11.38073328
30BRAF1.36935547
31SRPK11.33447958
32EIF2AK11.28792616
33DYRK1B1.28551476
34MAP2K61.27694602
35PDK11.24405040
36ARAF1.24342205
37CSNK1G11.21735985
38PIK3CG1.17627458
39CHEK21.14311081
40MAPK151.11889202
41BRD41.09749695
42NME21.05105480
43PBK1.05014689
44DAPK31.00339493
45NLK0.97433901
46TAOK30.97164353
47PASK0.96722251
48MAPKAPK50.96185927
49EPHA40.94882401
50PLK40.90772554
51CSNK1G20.90270454
52MAPKAPK30.89715143
53SGK2230.89095140
54SGK4940.89095140
55MAP3K60.88482830
56STK38L0.87932670
57PLK10.82847235
58DYRK30.82597436
59TESK20.80093198
60BMX0.77794837
61CDK140.75682016
62LATS10.75398720
63LATS20.74035495
64PDPK10.73935508
65MAP2K20.73475148
66ERN10.72824520
67STK100.71203223
68FLT30.68760261
69CDC42BPA0.67980827
70FGFR20.66983589
71PNCK0.65794813
72CDK120.64903642
73LMTK20.62673711
74AURKB0.61189911
75BUB10.60894284
76TYRO30.60655707
77MAP3K110.60476414
78MAP3K80.59093177
79CCNB10.58241169
80KDR0.57639360
81CDK80.57484920
82RPS6KB20.56152712
83STK160.56116434
84ZAP700.56111234
85MOS0.54770028
86FGR0.54586709
87CDC70.53734040
88STK40.53293620
89EIF2AK30.53100847
90IRAK10.51046914
91EGFR0.50770805
92PLK30.49080998
93CSNK1A10.47424631
94MKNK10.46724280
95STK30.45852474
96RPS6KB10.43270018
97MELK0.42794479
98CHEK10.42670390
99NME10.42136490
100MAP3K130.41784307
101PRKG20.40705560
102AURKA0.40402604
103MAP3K50.40168328
104PRKCQ0.39429413
105CAMK10.38875357
106CDK90.38483810
107CDK30.38087004
108MTOR0.36746794
109MAP4K10.36027130
110IRAK20.34935550
111PAK10.34304711
112ATR0.33572219
113FGFR10.31966985
114PAK20.30877858
115VRK10.29513105
116RPS6KC10.28320547
117RPS6KL10.28320547
118ATM0.27697891
119WNK10.27630262
120GRK60.27396186
121PKN10.27386229
122CSNK2A10.26856370
123BTK0.25859291
124BRSK20.24037202
125CAMKK10.23899690
126RPS6KA40.23874512
127RPS6KA10.23385231
128CDK50.23364987
129PRKAA10.23063408
130NEK60.20505037
131WEE10.19733831
132RIPK40.15528921
133CDK40.15446835
134CDK70.15168912
135PAK40.14585137
136WNK30.13936927
137CDK20.13085765
138CSNK2A20.10549723
139PRKCG0.09501324
140MAP3K90.08562372
141BMPR20.07446235
142DYRK20.07000306
143MAP3K10.06850634
144CDK60.05776985
145PIM10.05523413
146NTRK20.05424067
147CSNK1E0.05071283
148CDK10.04739851
149BMPR1B0.02892912
150LRRK20.02204457
151TGFBR10.00726477
152MAPK10.00395473

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051305.62148664
2Pancreatic secretion_Homo sapiens_hsa049724.41853548
3Fat digestion and absorption_Homo sapiens_hsa049753.91629852
4Hedgehog signaling pathway_Homo sapiens_hsa043403.60099874
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.51531949
6Linoleic acid metabolism_Homo sapiens_hsa005913.47854707
7Gap junction_Homo sapiens_hsa045403.08365932
8Protein digestion and absorption_Homo sapiens_hsa049742.99404085
9Vitamin B6 metabolism_Homo sapiens_hsa007502.95060510
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.91805023
11Pyruvate metabolism_Homo sapiens_hsa006202.68705991
12Propanoate metabolism_Homo sapiens_hsa006402.65308902
13Glycerolipid metabolism_Homo sapiens_hsa005612.56276232
14Basal transcription factors_Homo sapiens_hsa030222.49820779
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.49681055
16Fatty acid biosynthesis_Homo sapiens_hsa000612.42413742
17Cysteine and methionine metabolism_Homo sapiens_hsa002702.18645804
18Apoptosis_Homo sapiens_hsa042102.02856244
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93612073
20Fructose and mannose metabolism_Homo sapiens_hsa000511.93250963
21Alcoholism_Homo sapiens_hsa050341.92757093
22Selenocompound metabolism_Homo sapiens_hsa004501.87659945
23Fanconi anemia pathway_Homo sapiens_hsa034601.71934738
24Basal cell carcinoma_Homo sapiens_hsa052171.70851687
25Pentose phosphate pathway_Homo sapiens_hsa000301.68188118
26Folate biosynthesis_Homo sapiens_hsa007901.63141222
27Protein export_Homo sapiens_hsa030601.62027370
28RNA transport_Homo sapiens_hsa030131.60925081
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53521517
30Phagosome_Homo sapiens_hsa041451.53400492
31Other glycan degradation_Homo sapiens_hsa005111.49840221
32Arginine biosynthesis_Homo sapiens_hsa002201.46162900
33Ether lipid metabolism_Homo sapiens_hsa005651.45881328
34Ribosome_Homo sapiens_hsa030101.44729445
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.44686417
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.43977434
37Arachidonic acid metabolism_Homo sapiens_hsa005901.43699592
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36342895
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34602404
40Glucagon signaling pathway_Homo sapiens_hsa049221.34378914
41Oocyte meiosis_Homo sapiens_hsa041141.29587780
42Biosynthesis of amino acids_Homo sapiens_hsa012301.29207290
43RNA degradation_Homo sapiens_hsa030181.27995410
44Olfactory transduction_Homo sapiens_hsa047401.27769081
45Glutathione metabolism_Homo sapiens_hsa004801.26644520
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25275668
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20574848
48Purine metabolism_Homo sapiens_hsa002301.18027487
49Wnt signaling pathway_Homo sapiens_hsa043101.17922976
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16076413
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15507352
52Huntingtons disease_Homo sapiens_hsa050161.13459489
53Nitrogen metabolism_Homo sapiens_hsa009101.12473628
54Pyrimidine metabolism_Homo sapiens_hsa002401.10965081
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.07998823
56DNA replication_Homo sapiens_hsa030301.01645902
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98799852
58Carbon metabolism_Homo sapiens_hsa012000.91259913
59Fatty acid degradation_Homo sapiens_hsa000710.90117384
60mRNA surveillance pathway_Homo sapiens_hsa030150.87057786
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80119579
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77292995
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77285289
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75034067
65Fatty acid metabolism_Homo sapiens_hsa012120.73007478
66Antigen processing and presentation_Homo sapiens_hsa046120.68763223
67Thyroid cancer_Homo sapiens_hsa052160.68092534
68Renin-angiotensin system_Homo sapiens_hsa046140.67921400
69N-Glycan biosynthesis_Homo sapiens_hsa005100.65542500
70Dorso-ventral axis formation_Homo sapiens_hsa043200.64953130
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64863227
72Metabolic pathways_Homo sapiens_hsa011000.63949501
73Cardiac muscle contraction_Homo sapiens_hsa042600.63799597
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.62872149
75Cell cycle_Homo sapiens_hsa041100.60951719
76Chemical carcinogenesis_Homo sapiens_hsa052040.59163043
77Galactose metabolism_Homo sapiens_hsa000520.57732566
78PPAR signaling pathway_Homo sapiens_hsa033200.57319822
79Arginine and proline metabolism_Homo sapiens_hsa003300.55652994
80Base excision repair_Homo sapiens_hsa034100.55540074
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54944309
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54893078
83Hippo signaling pathway_Homo sapiens_hsa043900.54174994
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54133832
85Mineral absorption_Homo sapiens_hsa049780.53846596
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53124758
87Legionellosis_Homo sapiens_hsa051340.52801291
88Vitamin digestion and absorption_Homo sapiens_hsa049770.51469554
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51457803
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50711194
91Homologous recombination_Homo sapiens_hsa034400.48901221
92Taste transduction_Homo sapiens_hsa047420.48721538
93RNA polymerase_Homo sapiens_hsa030200.47824802
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46432471
95Phenylalanine metabolism_Homo sapiens_hsa003600.45790072
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45239530
97Proteasome_Homo sapiens_hsa030500.44895600
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44400671
99Parkinsons disease_Homo sapiens_hsa050120.44078935
100Systemic lupus erythematosus_Homo sapiens_hsa053220.40726773
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36557160
102Influenza A_Homo sapiens_hsa051640.36360286
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36260488
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34755020
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34675400
106Butanoate metabolism_Homo sapiens_hsa006500.34617166
107Phototransduction_Homo sapiens_hsa047440.33083163
108Tyrosine metabolism_Homo sapiens_hsa003500.31315970
109Amphetamine addiction_Homo sapiens_hsa050310.30897422
110VEGF signaling pathway_Homo sapiens_hsa043700.29876600
111One carbon pool by folate_Homo sapiens_hsa006700.29209923
112Viral carcinogenesis_Homo sapiens_hsa052030.28656362
113TGF-beta signaling pathway_Homo sapiens_hsa043500.28271468
114beta-Alanine metabolism_Homo sapiens_hsa004100.27589255
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27366025
116Spliceosome_Homo sapiens_hsa030400.26848873
117Adherens junction_Homo sapiens_hsa045200.26338999
118Alzheimers disease_Homo sapiens_hsa050100.25637871
119p53 signaling pathway_Homo sapiens_hsa041150.24536005
120Mismatch repair_Homo sapiens_hsa034300.24396689
121Endometrial cancer_Homo sapiens_hsa052130.23976069
122Nucleotide excision repair_Homo sapiens_hsa034200.23837152
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23516215
124Oxidative phosphorylation_Homo sapiens_hsa001900.22551374
125Non-homologous end-joining_Homo sapiens_hsa034500.21862919
126Melanogenesis_Homo sapiens_hsa049160.20722627
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.19453780
128ABC transporters_Homo sapiens_hsa020100.19391644
129Insulin secretion_Homo sapiens_hsa049110.17494401
130Inositol phosphate metabolism_Homo sapiens_hsa005620.17331538
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.17249041
132Prostate cancer_Homo sapiens_hsa052150.15914751
133Notch signaling pathway_Homo sapiens_hsa043300.15649515
134Epstein-Barr virus infection_Homo sapiens_hsa051690.15117359
135HTLV-I infection_Homo sapiens_hsa051660.14418797
136Ovarian steroidogenesis_Homo sapiens_hsa049130.13386396
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13375633
138Sulfur relay system_Homo sapiens_hsa041220.11561704
139Lysine degradation_Homo sapiens_hsa003100.10373703
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.09063202
141Herpes simplex infection_Homo sapiens_hsa051680.06856168
142Melanoma_Homo sapiens_hsa052180.06437238
143Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.01856723

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