TSHR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfate transport (GO:0008272)9.70391352
2low-density lipoprotein particle clearance (GO:0034383)9.36408343
3mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)8.72918878
4regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)8.63749658
5regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033398.26991516
6triglyceride catabolic process (GO:0019433)7.84704284
7cellular response to gonadotropin stimulus (GO:0071371)7.65111931
8nephron tubule formation (GO:0072079)7.42649513
9regulation of sequestering of triglyceride (GO:0010889)7.26083605
10white fat cell differentiation (GO:0050872)7.21903493
11acylglycerol catabolic process (GO:0046464)6.99778164
12neutral lipid catabolic process (GO:0046461)6.99778164
13positive regulation of hormone metabolic process (GO:0032352)6.96538355
14brown fat cell differentiation (GO:0050873)6.90032341
15biotin metabolic process (GO:0006768)6.57521338
16regulation of apoptotic process involved in morphogenesis (GO:1902337)6.55891734
17pattern specification involved in kidney development (GO:0061004)6.47728853
18hydrogen peroxide catabolic process (GO:0042744)6.25312353
19negative regulation of mesenchymal cell apoptotic process (GO:2001054)6.24471386
20valine metabolic process (GO:0006573)6.08853520
21triglyceride biosynthetic process (GO:0019432)5.72458305
22lipid particle organization (GO:0034389)5.54979239
23acylglycerol biosynthetic process (GO:0046463)5.51133165
24neutral lipid biosynthetic process (GO:0046460)5.51133165
25mesonephros development (GO:0001823)5.50773640
26response to dietary excess (GO:0002021)5.50175346
27metanephric tubule development (GO:0072170)5.48776029
28metanephric nephron tubule development (GO:0072234)5.48776029
29urogenital system development (GO:0001655)5.45625274
30phenol-containing compound metabolic process (GO:0018958)5.38114342
31positive regulation of cellular amine metabolic process (GO:0033240)5.37514873
32hormone biosynthetic process (GO:0042446)5.33161764
33glycerolipid catabolic process (GO:0046503)5.30861614
34regulation of nephron tubule epithelial cell differentiation (GO:0072182)5.27261371
35fatty acid transmembrane transport (GO:1902001)5.25166849
36positive regulation of fatty acid beta-oxidation (GO:0032000)5.20827353
37negative regulation of macrophage derived foam cell differentiation (GO:0010745)5.19911980
38positive regulation of fatty acid oxidation (GO:0046321)5.16682696
39ovulation from ovarian follicle (GO:0001542)5.05490902
40metanephric nephron epithelium development (GO:0072243)4.97562860
41negative regulation of microtubule polymerization (GO:0031115)4.93027660
42response to gonadotropin (GO:0034698)4.92924224
43regulation of cholesterol storage (GO:0010885)4.91664278
44regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.90317110
45negative regulation of hormone biosynthetic process (GO:0032353)4.72548319
46protein heterotrimerization (GO:0070208)4.68915195
47lipid storage (GO:0019915)4.68850536
48carnitine shuttle (GO:0006853)4.68559879
49regulation of mesenchymal cell apoptotic process (GO:2001053)4.65920029
50regulation of stem cell maintenance (GO:2000036)4.62217367
51metanephric epithelium development (GO:0072207)4.57137126
52long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.49660851
53mesenchymal to epithelial transition (GO:0060231)4.49060006
54positive regulation of metanephros development (GO:0072216)4.46788461
55regulation of hormone metabolic process (GO:0032350)4.44138293
56sulfur compound transport (GO:0072348)4.38985724
57fatty-acyl-CoA metabolic process (GO:0035337)4.37779904
58triglyceride metabolic process (GO:0006641)4.35274378
59positive regulation of cellular response to insulin stimulus (GO:1900078)4.35121372
60fatty-acyl-CoA biosynthetic process (GO:0046949)4.33282538
61long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.32418342
62fatty acid beta-oxidation (GO:0006635)4.30458407
63negative regulation of kidney development (GO:0090185)4.27307487
64specification of organ identity (GO:0010092)4.25395826
65thioester biosynthetic process (GO:0035384)4.23721153
66acyl-CoA biosynthetic process (GO:0071616)4.23721153
67regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.21326063
68positive regulation of glucose import (GO:0046326)4.17421361
69branched-chain amino acid metabolic process (GO:0009081)4.16514874
70hydrogen peroxide metabolic process (GO:0042743)4.13996100
71negative regulation of hormone metabolic process (GO:0032351)4.12856306
72acylglycerol metabolic process (GO:0006639)4.11882882
73negative regulation of protein autophosphorylation (GO:0031953)4.08129888
74neutral lipid metabolic process (GO:0006638)4.06792767
75regulation of myelination (GO:0031641)4.06390427
76regulation of macrophage derived foam cell differentiation (GO:0010743)4.00620249
77thyroid hormone generation (GO:0006590)34.0460773
78fatty acid homeostasis (GO:0055089)3.99735567
79positive regulation of insulin receptor signaling pathway (GO:0046628)3.99356130
80pentose-phosphate shunt (GO:0006098)3.96817382
81coenzyme A biosynthetic process (GO:0015937)3.95820939
82regulation of cAMP-dependent protein kinase activity (GO:2000479)3.94823229
83branched-chain amino acid catabolic process (GO:0009083)3.93395581
84negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.91664763
85regulation of steroid hormone biosynthetic process (GO:0090030)3.91513208
86carnitine transmembrane transport (GO:1902603)3.90254013
87negative regulation of phagocytosis (GO:0050765)3.89968717
88CDP-diacylglycerol biosynthetic process (GO:0016024)3.89297124
89regulation of fatty acid beta-oxidation (GO:0031998)3.88740846
90NADPH regeneration (GO:0006740)3.87360128
91positive regulation of fatty acid metabolic process (GO:0045923)3.84506746
92growth hormone receptor signaling pathway (GO:0060396)3.83253848
93fatty acid oxidation (GO:0019395)3.76897505
94glycerol metabolic process (GO:0006071)3.75081458
95female gonad development (GO:0008585)3.74259009
96regulation of fatty acid oxidation (GO:0046320)3.73124960
97lipid oxidation (GO:0034440)3.70163527
98regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.69438070
99positive regulation of glucose transport (GO:0010828)3.67055621
100L-serine transport (GO:0015825)3.65556339
101plasma lipoprotein particle clearance (GO:0034381)3.64972591
102fatty acid catabolic process (GO:0009062)3.64609361
103negative regulation of lipid storage (GO:0010888)3.63005447
104positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.62851368
105negative regulation of granulocyte differentiation (GO:0030853)3.62173902
106cellular response to lithium ion (GO:0071285)3.60550777
107acetyl-CoA metabolic process (GO:0006084)3.58477286
108regulation of glycogen (starch) synthase activity (GO:2000465)3.56327368
109amino-acid betaine transport (GO:0015838)3.56245074
110carnitine transport (GO:0015879)3.56245074
111cellular response to epinephrine stimulus (GO:0071872)3.53984222
112diacylglycerol metabolic process (GO:0046339)3.53106923
113positive regulation of glomerulus development (GO:0090193)3.51382269
114positive regulation of lipid catabolic process (GO:0050996)3.49518007
115retina vasculature morphogenesis in camera-type eye (GO:0061299)3.49328147
116CDP-diacylglycerol metabolic process (GO:0046341)3.46745525
117membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.44485508
118negative regulation of metanephros development (GO:0072217)3.43481384
119complement activation, alternative pathway (GO:0006957)3.42034698
120adaptation of signaling pathway (GO:0023058)3.33611662
121positive regulation of cholesterol efflux (GO:0010875)3.33254282
122cellular response to growth hormone stimulus (GO:0071378)3.32791618
123alpha-linolenic acid metabolic process (GO:0036109)3.32002174
124phosphatidic acid biosynthetic process (GO:0006654)3.31178978
125phosphatidic acid metabolic process (GO:0046473)3.31178978
126positive regulation of sterol transport (GO:0032373)3.29360476
127positive regulation of cholesterol transport (GO:0032376)3.29360476
128negative regulation of macrophage differentiation (GO:0045650)3.27939944
129alditol metabolic process (GO:0019400)3.26673675
130regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.25138082
131coenzyme A metabolic process (GO:0015936)3.21597072
132hair follicle morphogenesis (GO:0031069)3.19617267
133glomerular filtration (GO:0003094)3.19424937
134intracellular lipid transport (GO:0032365)3.18293770
135negative regulation of amino acid transport (GO:0051956)3.17188891
136nephron tubule development (GO:0072080)3.17160681
137oxaloacetate metabolic process (GO:0006107)3.16711331
138phosphatidylinositol dephosphorylation (GO:0046856)3.16484523
139embryonic hemopoiesis (GO:0035162)3.15073595
140positive regulation of lipid storage (GO:0010884)3.14682481
141regulation of gonadotropin secretion (GO:0032276)3.13003297
142serine transport (GO:0032329)3.11614065
143phospholipid dephosphorylation (GO:0046839)3.08818447
144negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.07948166
145regulation of Rap GTPase activity (GO:0032317)3.07591023
146fat cell differentiation (GO:0045444)3.06519698
147hormone metabolic process (GO:0042445)3.05770295
148tricarboxylic acid metabolic process (GO:0072350)3.05667323
149response to hydroperoxide (GO:0033194)3.01084687
150thyroid hormone metabolic process (GO:0042403)27.5784343
151membrane repolarization during action potential (GO:0086011)2.99413776
152positive regulation of mesonephros development (GO:0061213)2.95677414
153regulation of metanephros development (GO:0072215)2.91488221
154renal tubule development (GO:0061326)2.88293238
155regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.87711308
156negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.80286218
157epithelial cell morphogenesis (GO:0003382)2.72772143
158regulation of lipoprotein metabolic process (GO:0050746)2.72646884
159positive regulation of p38MAPK cascade (GO:1900745)2.70011127
160negative regulation of stem cell differentiation (GO:2000737)2.57165898
161carnitine metabolic process (GO:0009437)2.53114642
162positive regulation of Rap GTPase activity (GO:0032854)2.52006815
163response to epinephrine (GO:0071871)2.50052627
164nephron epithelium development (GO:0072009)2.46519038
165embryonic epithelial tube formation (GO:0001838)2.42539412
166regulation of mesonephros development (GO:0061217)2.40301995
167regulation of energy homeostasis (GO:2000505)2.38766362
168branching involved in ureteric bud morphogenesis (GO:0001658)2.37405678
169inorganic anion transport (GO:0015698)2.34168969
170regulation of hormone biosynthetic process (GO:0046885)2.31577833
171epithelial tube formation (GO:0072175)2.28521054
172positive regulation of digestive system process (GO:0060456)2.27995218
173pericardium development (GO:0060039)2.27419315
174thymus development (GO:0048538)2.26670896
175cellular modified amino acid metabolic process (GO:0006575)2.18702326
176potassium ion export (GO:0071435)2.17743452
177regulation of p38MAPK cascade (GO:1900744)2.17739066
178synapse assembly (GO:0007416)2.17348366
179regulation of water loss via skin (GO:0033561)2.15984801
180regulation of hormone levels (GO:0010817)2.13460998
181regulation of apoptotic cell clearance (GO:2000425)2.09578881
182cellular response to cAMP (GO:0071320)2.07536913
183negative regulation of fatty acid transport (GO:2000192)2.05769184
184regulation of microtubule polymerization (GO:0031113)2.03353304
185regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.03314853
186cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.00423977
187thyroid gland development (GO:0030878)14.3406139
188sulfate transmembrane transport (GO:1902358)11.5000178
189flavonoid metabolic process (GO:0009812)1.99551428
190phospholipid homeostasis (GO:0055091)1.99222212
191regulation of glucose import in response to insulin stimulus (GO:2001273)1.97253731
192amino-acid betaine metabolic process (GO:0006577)1.95535667
193negative regulation of insulin secretion (GO:0046676)1.94854479
194atrial cardiac muscle cell action potential (GO:0086014)1.94568200
195phenol-containing compound catabolic process (GO:0019336)1.92658443
196negative regulation of lipase activity (GO:0060192)1.92491041

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.51490146
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons4.99612494
3EZH2_22144423_ChIP-Seq_EOC_Human4.61985147
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.33511037
5CLOCK_20551151_ChIP-Seq_293T_Human4.29768511
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.64406071
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.21314174
8AR_21572438_ChIP-Seq_LNCaP_Human2.92532574
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.71489786
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.53184807
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52721457
12PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.51758290
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39293452
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.29706323
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27472980
16GBX2_23144817_ChIP-Seq_PC3_Human2.16970673
17SMAD3_21741376_ChIP-Seq_HESCs_Human2.12621578
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.05882767
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.00205820
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse13.7099354
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95425128
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93486307
23PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.88185824
24CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.79278175
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72222310
26BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.69210012
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.61850534
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61242303
29IGF1R_20145208_ChIP-Seq_DFB_Human1.60578753
30GATA1_22025678_ChIP-Seq_K562_Human1.60246199
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58438940
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58377293
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57379279
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57004663
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.56597119
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.56241783
37NFIB_24661679_ChIP-Seq_LUNG_Mouse1.54802539
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52776484
39TP53_16413492_ChIP-PET_HCT116_Human1.52767580
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51558634
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.50824502
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48203859
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42038698
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.39152485
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.37999231
46TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37914371
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37858106
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35265739
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35265739
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34507019
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33667953
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33494249
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30636067
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28859343
55* CJUN_26792858_Chip-Seq_BT549_Human1.27505071
56SMAD4_21799915_ChIP-Seq_A2780_Human1.25981261
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25582547
58SMAD4_21741376_ChIP-Seq_HESCs_Human1.24862867
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22932458
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.22856719
61VDR_24787735_ChIP-Seq_THP-1_Human1.22493309
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21700241
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21683589
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20355598
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19641565
66TBX20_22328084_ChIP-Seq_HEART_Mouse1.17785966
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.17785966
68RUNX_20019798_ChIP-Seq_JUKART_Human1.16117117
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15919422
70SCL_19346495_ChIP-Seq_HPC-7_Human1.15484530
71* SMAD3_21741376_ChIP-Seq_EPCs_Human1.15390131
72* RING1B_27294783_Chip-Seq_NPCs_Mouse1.14359621
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14072909
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13493297
75WDR5_24793694_ChIP-Seq_LNCAP_Human1.12967109
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.12653734
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12305642
78ER_23166858_ChIP-Seq_MCF-7_Human1.10710166
79ZNF263_19887448_ChIP-Seq_K562_Human1.08998362
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08756492
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07433149
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07272634
83FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06418808
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06239421
85SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06220650
86RUNX2_22187159_ChIP-Seq_PCA_Human1.05870892
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05442039
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04595042
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03195548
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.02651560
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02479362
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01736018
93* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01055031
94TP53_18474530_ChIP-ChIP_U2OS_Human1.00973109
95EGR1_19374776_ChIP-ChIP_THP-1_Human1.00351176
96TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00149138
97BCAT_22108803_ChIP-Seq_LS180_Human0.99565984
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98703190
99FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98346604
100TCF4_18268006_ChIP-ChIP_LS174T_Human0.98241062
101SOX2_20726797_ChIP-Seq_SW620_Human0.98189514
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96979254
103* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96782936
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95773131
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95187718
106RXR_22108803_ChIP-Seq_LS180_Human0.93839544
107* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93651054
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93154873
109ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93019389
110AR_19668381_ChIP-Seq_PC3_Human0.92243760
111* STAT3_23295773_ChIP-Seq_U87_Human0.91884170
112* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91707300
113SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91228792
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88955601
115SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88614891
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86769018
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86769018
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86557158
119* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86518067
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84946846
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84721391
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84528278
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84525316
124TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82784853
125DROSHA_22980978_ChIP-Seq_HELA_Human0.82374330
126P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81000074
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80984665
128HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79275523
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.78241522
130GATA1_19941826_ChIP-Seq_K562_Human0.77224900
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76655512
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76353329
133EED_16625203_ChIP-ChIP_MESCs_Mouse0.75078270
134GATA3_24758297_ChIP-Seq_MCF-7_Human0.74769569
135SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74758818
136* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.74679259
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.74659656
138IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.74549213
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73734047
140FOXA2_19822575_ChIP-Seq_HepG2_Human0.73232439
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72624829
142KLF4_19829295_ChIP-Seq_ESCs_Human0.72477207
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70446586
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69773095
145* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.67572370
146KDM2B_26808549_Chip-Seq_K562_Human0.67370615
147IRF8_21731497_ChIP-ChIP_J774_Mouse0.67057376
148AHR_22903824_ChIP-Seq_MCF-7_Human0.66353246
149ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.65224281
150GATA2_19941826_ChIP-Seq_K562_Human0.64644876
151JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64504698
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.64304215
153SOX2_27498859_Chip-Seq_STOMACH_Mouse0.63890966
154PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.63347240
155ISL1_27105846_Chip-Seq_CPCs_Mouse0.63035278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose8.32702852
2MP0000383_abnormal_hair_follicle5.61481737
3MP0004043_abnormal_pH_regulation5.42103221
4MP0004885_abnormal_endolymph5.36734976
5MP0005666_abnormal_adipose_tissue5.32161070
6MP0008438_abnormal_cutaneous_collagen5.01949174
7MP0004130_abnormal_muscle_cell4.58862369
8MP0010678_abnormal_skin_adnexa4.56866915
9MP0004185_abnormal_adipocyte_glucose4.51851039
10MP0005375_adipose_tissue_phenotype4.14909361
11MP0003879_abnormal_hair_cell4.01208557
12MP0001485_abnormal_pinna_reflex3.68434202
13MP0000013_abnormal_adipose_tissue3.50822076
14MP0010368_abnormal_lymphatic_system3.36633300
15MP0002837_dystrophic_cardiac_calcinosis3.36291120
16MP0005275_abnormal_skin_tensile3.07959468
17MP0004742_abnormal_vestibular_system3.06757815
18MP0000003_abnormal_adipose_tissue3.06348864
19MP0002971_abnormal_brown_adipose2.99092281
20MP0009115_abnormal_fat_cell2.81226776
21MP0003890_abnormal_embryonic-extraembry2.51187132
22MP0010329_abnormal_lipoprotein_level2.50901520
23MP0005334_abnormal_fat_pad2.48765619
24* MP0002876_abnormal_thyroid_physiology2.41987998
25MP0003191_abnormal_cellular_cholesterol2.36325498
26MP0001661_extended_life_span2.35621838
27MP0002970_abnormal_white_adipose2.13485630
28MP0004272_abnormal_basement_membrane2.10131404
29MP0003868_abnormal_feces_composition1.98614262
30MP0003959_abnormal_lean_body1.91358496
31MP0002254_reproductive_system_inflammat1.78795302
32MP0005535_abnormal_body_temperature1.78158867
33* MP0002118_abnormal_lipid_homeostasis1.70862574
34MP0001881_abnormal_mammary_gland1.66858699
35MP0003690_abnormal_glial_cell1.66128112
36MP0003705_abnormal_hypodermis_morpholog1.62524797
37MP0002638_abnormal_pupillary_reflex1.58335333
38MP0003938_abnormal_ear_development1.51863527
39MP0003186_abnormal_redox_activity1.44926242
40MP0005448_abnormal_energy_balance1.43469111
41MP0009780_abnormal_chondrocyte_physiolo1.39965917
42MP0001727_abnormal_embryo_implantation1.35214730
43MP0003724_increased_susceptibility_to1.31702950
44MP0003136_yellow_coat_color1.30012966
45MP0005452_abnormal_adipose_tissue1.29888315
46MP0003566_abnormal_cell_adhesion1.27712960
47MP0002822_catalepsy1.24564874
48MP0003011_delayed_dark_adaptation1.22845997
49MP0000631_abnormal_neuroendocrine_gland1.22779532
50MP0004264_abnormal_extraembryonic_tissu1.22291786
51* MP0000026_abnormal_inner_ear1.16634043
52* MP0001963_abnormal_hearing_physiology1.16342310
53MP0003183_abnormal_peptide_metabolism1.13170512
54MP0000920_abnormal_myelination1.12489289
55MP0001765_abnormal_ion_homeostasis1.12091589
56MP0003045_fibrosis1.11289608
57MP0002796_impaired_skin_barrier1.11162284
58MP0000751_myopathy1.08907363
59MP0002078_abnormal_glucose_homeostasis1.08321249
60MP0002166_altered_tumor_susceptibility1.07816895
61MP0000609_abnormal_liver_physiology1.07434271
62MP0006138_congestive_heart_failure1.05696045
63MP0002060_abnormal_skin_morphology1.04305106
64MP0001177_atelectasis1.03704886
65MP0004381_abnormal_hair_follicle1.03001958
66MP0002909_abnormal_adrenal_gland1.01850712
67MP0000343_altered_response_to1.00051885
68MP0005645_abnormal_hypothalamus_physiol0.99248322
69MP0003828_pulmonary_edema0.97988997
70MP0001756_abnormal_urination0.96532159
71MP0005164_abnormal_response_to0.96387736
72MP0000750_abnormal_muscle_regeneration0.96362420
73MP0005379_endocrine/exocrine_gland_phen0.90828060
74MP0008995_early_reproductive_senescence0.90044099
75MP0002653_abnormal_ependyma_morphology0.88850349
76MP0008775_abnormal_heart_ventricle0.87443702
77MP0005620_abnormal_muscle_contractility0.87254507
78MP0004484_altered_response_of0.86656382
79MP0002229_neurodegeneration0.83394792
80MP0001502_abnormal_circadian_rhythm0.82389561
81MP0004134_abnormal_chest_morphology0.81863078
82* MP0008569_lethality_at_weaning0.81829480
83MP0003948_abnormal_gas_homeostasis0.80998560
84MP0001764_abnormal_homeostasis0.79876511
85MP0002006_tumorigenesis0.79839041
86MP0008875_abnormal_xenobiotic_pharmacok0.79188481
87MP0001984_abnormal_olfaction0.76677768
88MP0005365_abnormal_bile_salt0.76137308
89* MP0000681_abnormal_thyroid_gland0.74880568
90MP0001958_emphysema0.73968085
91MP0005584_abnormal_enzyme/coenzyme_acti0.72897578
92MP0003950_abnormal_plasma_membrane0.72780316
93MP0001544_abnormal_cardiovascular_syste0.72448924
94MP0005385_cardiovascular_system_phenoty0.72448924
95MP0005076_abnormal_cell_differentiation0.72136478
96* MP0003953_abnormal_hormone_level0.71848533
97MP0009643_abnormal_urine_homeostasis0.70695873
98MP0005409_darkened_coat_color0.70431850
99MP0003935_abnormal_craniofacial_develop0.69960458
100MP0000759_abnormal_skeletal_muscle0.68750762
101MP0010771_integument_phenotype0.68466293
102MP0002168_other_aberrant_phenotype0.67432618
103MP0000049_abnormal_middle_ear0.65457788
104MP0002133_abnormal_respiratory_system0.65290658
105MP0005388_respiratory_system_phenotype0.65290658
106MP0005647_abnormal_sex_gland0.64920141
107MP0000377_abnormal_hair_follicle0.64796848
108MP0010234_abnormal_vibrissa_follicle0.64744405
109MP0002295_abnormal_pulmonary_circulatio0.64109054
110MP0004087_abnormal_muscle_fiber0.63944866
111MP0002877_abnormal_melanocyte_morpholog0.63148023
112MP0005058_abnormal_lysosome_morphology0.63067621
113MP0004215_abnormal_myocardial_fiber0.62302405
114MP0001533_abnormal_skeleton_physiology0.62283187
115MP0005023_abnormal_wound_healing0.62189762
116MP0005167_abnormal_blood-brain_barrier0.61355338
117MP0003936_abnormal_reproductive_system0.60255128
118MP0002108_abnormal_muscle_morphology0.59585690
119MP0004147_increased_porphyrin_level0.59401255
120MP0000604_amyloidosis0.58911872
121MP0002177_abnormal_outer_ear0.58488199
122MP0005377_hearing/vestibular/ear_phenot0.58040307
123MP0003878_abnormal_ear_physiology0.58040307
124* MP0001501_abnormal_sleep_pattern0.57980607
125MP0000249_abnormal_blood_vessel0.57525017
126MP0002998_abnormal_bone_remodeling0.54779263
127MP0003329_amyloid_beta_deposits0.54471330
128MP0000230_abnormal_systemic_arterial0.54389049
129MP0008961_abnormal_basal_metabolism0.53595508
130MP0001879_abnormal_lymphatic_vessel0.53125955
131MP0010386_abnormal_urinary_bladder0.52917313
132MP0000858_altered_metastatic_potential0.52026887
133MP0005319_abnormal_enzyme/_coenzyme0.50746819
134MP0005310_abnormal_salivary_gland0.50696062
135MP0006054_spinal_hemorrhage0.50164448
136MP0003448_altered_tumor_morphology0.50114663
137MP0000627_abnormal_mammary_gland0.49721892
138MP0005595_abnormal_vascular_smooth0.49283652
139MP0002972_abnormal_cardiac_muscle0.47754455
140MP0000367_abnormal_coat/_hair0.47116894
141MP0005171_absent_coat_pigmentation0.46852713
142MP0002332_abnormal_exercise_endurance0.45415631
143MP0010352_gastrointestinal_tract_polyps0.43867303
144MP0008004_abnormal_stomach_pH0.43450706
145MP0000427_abnormal_hair_cycle0.43342982
146MP0005165_increased_susceptibility_to0.43342711
147MP0002090_abnormal_vision0.43024792
148MP0006036_abnormal_mitochondrial_physio0.42198278
149MP0001851_eye_inflammation0.40307749
150MP0000465_gastrointestinal_hemorrhage0.39553232
151MP0003646_muscle_fatigue0.38099811
152MP0004084_abnormal_cardiac_muscle0.37372772
153MP0009278_abnormal_bone_marrow0.36711694
154MP0003755_abnormal_palate_morphology0.35684190
155MP0003638_abnormal_response/metabolism_0.35057851
156MP0003137_abnormal_impulse_conducting0.33079557
157* MP0009642_abnormal_blood_homeostasis0.31804227
158MP0001663_abnormal_digestive_system0.31075178
159MP0005075_abnormal_melanosome_morpholog0.30950648
160MP0005395_other_phenotype0.30790013
161MP0003300_gastrointestinal_ulcer0.30711455
162MP0009703_decreased_birth_body0.30205573
163MP0002136_abnormal_kidney_physiology0.29957060
164MP0003453_abnormal_keratinocyte_physiol0.29460956
165MP0003937_abnormal_limbs/digits/tail_de0.28330726
166MP0003942_abnormal_urinary_system0.27658494
167* MP0001731_abnormal_postnatal_growth0.26619290
168MP0001145_abnormal_male_reproductive0.26023814

Predicted human phenotypes

RankGene SetZ-score
1Congenital sensorineural hearing impairment (HP:0008527)9.92453766
2Oligomenorrhea (HP:0000876)9.10862134
3Small epiphyses (HP:0010585)8.64809150
4Thyroid carcinoma (HP:0002890)8.40874907
5Abnormality of cochlea (HP:0000375)8.06171821
6Acanthosis nigricans (HP:0000956)7.63621274
7Hypothermia (HP:0002045)7.28131358
8Abnormal hair laboratory examination (HP:0003328)6.43189935
9Hypertriglyceridemia (HP:0002155)6.35143511
10Morphological abnormality of the inner ear (HP:0011390)6.34098295
11* Hypothyroidism (HP:0000821)5.68623689
12Delayed epiphyseal ossification (HP:0002663)5.55166550
13Hyperglycinuria (HP:0003108)5.27474882
14Irregular epiphyses (HP:0010582)4.91736914
15Mild short stature (HP:0003502)4.73680504
16Long foot (HP:0001833)4.52876067
17Insulin-resistant diabetes mellitus (HP:0000831)4.51709199
18Complement deficiency (HP:0004431)4.47495457
19* Coarse facial features (HP:0000280)4.31282306
20Difficulty running (HP:0009046)4.17784748
21Epiphyseal dysplasia (HP:0002656)4.16089307
22Aortic dissection (HP:0002647)4.07469114
23Abnormality of serine family amino acid metabolism (HP:0010894)4.07066017
24Abnormality of glycine metabolism (HP:0010895)4.07066017
25Neoplasm of the thyroid gland (HP:0100031)3.90812266
26Hyperparathyroidism (HP:0000843)3.83432257
27Increased connective tissue (HP:0009025)3.76283011
28Pigmentary retinal degeneration (HP:0001146)3.65292626
29Growth hormone excess (HP:0000845)3.64973116
30Ankle contracture (HP:0006466)3.51045531
31Hemorrhage of the eye (HP:0011885)3.46377647
32Insulin resistance (HP:0000855)3.46025714
33* Constipation (HP:0002019)3.42455354
34Bone cyst (HP:0012062)3.34630865
35Abnormality of proline metabolism (HP:0010907)3.32776388
36Hydroxyprolinuria (HP:0003080)3.32776388
37Cerebral aneurysm (HP:0004944)3.29748058
38Subcapsular cataract (HP:0000523)3.28192642
39Arterial tortuosity (HP:0005116)3.27533933
40Tracheal stenosis (HP:0002777)3.21095370
41Increased variability in muscle fiber diameter (HP:0003557)3.17238123
42Broad metatarsal (HP:0001783)3.15402958
43Abnormality of complement system (HP:0005339)3.10933492
44Macroglossia (HP:0000158)3.10904092
45Bradycardia (HP:0001662)3.04893839
46Autoimmune thrombocytopenia (HP:0001973)3.02767613
47Type 1 muscle fiber predominance (HP:0003803)2.99019158
48Vascular tortuosity (HP:0004948)2.96761739
49Large hands (HP:0001176)2.95717891
50Reduced subcutaneous adipose tissue (HP:0003758)2.95560194
51Slender build (HP:0001533)2.95163913
52Aortic aneurysm (HP:0004942)2.93214523
53Systemic lupus erythematosus (HP:0002725)2.87415165
54Myoglobinuria (HP:0002913)2.86141763
55Premature rupture of membranes (HP:0001788)2.84860592
56Hoarse voice (HP:0001609)2.84269133
57Follicular hyperkeratosis (HP:0007502)2.81377439
58Spondylolisthesis (HP:0003302)2.79004919
59Tetraparesis (HP:0002273)2.76196662
60Muscle fiber splitting (HP:0003555)2.74114552
61Spinal rigidity (HP:0003306)2.70633724
62Ketoacidosis (HP:0001993)2.67013579
63Facial diplegia (HP:0001349)2.66317662
64Abnormality of skeletal muscle fiber size (HP:0012084)2.63540161
65Abnormal eating behavior (HP:0100738)2.59001144
66Multiple enchondromatosis (HP:0005701)2.58265789
67Rectal prolapse (HP:0002035)2.57232768
68Hypoalphalipoproteinemia (HP:0003233)2.53467100
69Testicular atrophy (HP:0000029)2.53445359
70Myocardial infarction (HP:0001658)2.51929951
71Abnormality of fatty-acid metabolism (HP:0004359)2.47344360
72Hyporeflexia of lower limbs (HP:0002600)2.47129664
73Right ventricular cardiomyopathy (HP:0011663)2.46856963
74Ketosis (HP:0001946)2.46549188
75Epidermoid cyst (HP:0200040)2.44449643
76Pancreatitis (HP:0001733)2.43404511
77Lower limb hyperreflexia (HP:0002395)2.42818950
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.41894483
79* Umbilical hernia (HP:0001537)2.38758688
80Prominent supraorbital ridges (HP:0000336)2.38482970
81Mitral valve prolapse (HP:0001634)2.37221308
82Abnormal hemoglobin (HP:0011902)2.32517258
83Lipoatrophy (HP:0100578)2.31502527
84Ventricular fibrillation (HP:0001663)2.29510637
85Polyphagia (HP:0002591)2.28334699
86Increased muscle lipid content (HP:0009058)2.27943222
87Proximal amyotrophy (HP:0007126)2.19540563
88Bronchomalacia (HP:0002780)2.17316222
89Hypoglycemic coma (HP:0001325)2.16020669
90* Hyperpituitarism (HP:0010514)2.14725861
91Rhabdomyolysis (HP:0003201)2.14212176
92Abnormal cartilage morphology (HP:0002763)2.12823899
93Neonatal hypoglycemia (HP:0001998)2.10603463
94Shallow orbits (HP:0000586)2.10431537
95* Hyperthyroidism (HP:0000836)2.09475638
96Polar cataract (HP:0010696)2.09439532
97Venous abnormality (HP:0002624)2.05636159
98Scapular winging (HP:0003691)2.05477943
99Abnormality of the dental pulp (HP:0006479)2.04460727
100Glucose intolerance (HP:0000833)2.04130222
101Delayed closure of the anterior fontanelle (HP:0001476)2.01074492
102Polygenic inheritance (HP:0010982)2.00070711
103* Goiter (HP:0000853)17.3020305
104* Thyroid-stimulating hormone excess (HP:0002925)11.5071319
105Pili torti (HP:0003777)10.5066536
106* Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)10.2949883
107Fibular hypoplasia (HP:0003038)1.98868249
108Toxemia of pregnancy (HP:0100603)1.98135707
109Hypercortisolism (HP:0001578)1.97756602
110Skin nodule (HP:0200036)1.95228724
111Decreased subcutaneous fat (HP:0001002)1.94161229
112Nausea (HP:0002018)1.92759892
113Hyperglycinemia (HP:0002154)1.90675225
114Hyperammonemia (HP:0001987)1.89831735
115Amelogenesis imperfecta (HP:0000705)1.89329456
116Abnormality of permanent molar morphology (HP:0011071)1.89175790
117Abnormality of the dental root (HP:0006486)1.89175790
118Taurodontia (HP:0000679)1.89175790
119Striae distensae (HP:0001065)1.88467879
120Soft skin (HP:0000977)1.87762919
121Turricephaly (HP:0000262)1.87628677
122Amyloidosis (HP:0011034)1.84232606
123Genu varum (HP:0002970)1.82875956
124Abnormality of the vitreous humor (HP:0004327)1.82757734
125Hyperactive renin-angiotensin system (HP:0000841)1.82724540
126Laryngomalacia (HP:0001601)1.82696238
127Protrusio acetabuli (HP:0003179)1.82140144
128Osteolytic defects of the hand bones (HP:0009699)1.81475975
129Osteolytic defects of the phalanges of the hand (HP:0009771)1.81475975
130Myotonia (HP:0002486)1.79867330
131Enlarged penis (HP:0000040)1.79402059
132Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79303655
133Dicarboxylic aciduria (HP:0003215)1.79303655
134Hypoplasia of the iris (HP:0007676)1.79051675
135Gonadotropin excess (HP:0000837)1.78559100
136Abdominal distention (HP:0003270)1.77438795
137Abnormality of the lumbar spine (HP:0100712)1.77258092
138Aneurysm (HP:0002617)1.76575851
139Dilatation of the ascending aorta (HP:0005111)1.76317378
140Truncal obesity (HP:0001956)1.75546019
141Abnormality of molar morphology (HP:0011070)1.73927470
142Abnormality of molar (HP:0011077)1.73927470
143Large for gestational age (HP:0001520)1.67898766
144Neonatal respiratory distress (HP:0002643)1.59682331
145Dysdiadochokinesis (HP:0002075)1.57626040
146Hypokinesia (HP:0002375)1.48749180
147Adrenal overactivity (HP:0002717)1.48321045
148Split foot (HP:0001839)1.44533572
149Abnormality of secondary sexual hair (HP:0009888)1.44108924
150Abnormality of the axillary hair (HP:0100134)1.44108924
151Subacute progressive viral hepatitis (HP:0006572)1.43899573
152Macroorchidism (HP:0000053)1.42864134
153Vertigo (HP:0002321)1.40404795
154Abnormal epiphyseal ossification (HP:0010656)1.38264682
155Hyperbilirubinemia (HP:0002904)1.36942537
156Germ cell neoplasia (HP:0100728)1.33548987
157Dysmetric saccades (HP:0000641)1.30859330
158Glomerulonephritis (HP:0000099)1.29751964
159Choanal atresia (HP:0000453)1.29027550
160Seborrheic dermatitis (HP:0001051)1.26914732
161Hyperaldosteronism (HP:0000859)1.26896850
162Ulnar bowing (HP:0003031)1.25747839
163Hyperkalemia (HP:0002153)1.25109282
164Labial hypoplasia (HP:0000066)1.25104175
165Vaginal fistula (HP:0004320)1.21525585
166Syncope (HP:0001279)1.21413167
167Osteoarthritis (HP:0002758)1.18753480
168Hypoplastic female external genitalia (HP:0012815)1.17781331
169Prolonged QT interval (HP:0001657)1.17027927
170Synostosis involving the elbow (HP:0003938)1.12473574
171Humeroradial synostosis (HP:0003041)1.12473574
172Interstitial pulmonary disease (HP:0006530)1.12140663
173Purpura (HP:0000979)1.11597164
174Abnormality of chloride homeostasis (HP:0011422)1.06391781
175Autoimmune hemolytic anemia (HP:0001890)1.02232127
176Dry skin (HP:0000958)1.01745663
177Lethargy (HP:0001254)1.01482642
178Atelectasis (HP:0100750)0.99710172
179Broad face (HP:0000283)0.97334436
180Nephropathy (HP:0000112)0.97028337
181Viral hepatitis (HP:0006562)0.96773988
182Vascular calcification (HP:0004934)0.95798830
183Anal stenosis (HP:0002025)0.90921092
184Cardiovascular calcification (HP:0011915)0.90509474
185Abnormality of the gastric mucosa (HP:0004295)0.89295656
186Acne (HP:0001061)0.88920128
187Overgrowth (HP:0001548)0.88279204
188Abnormality of renin-angiotensin system (HP:0000847)0.87710092
189Truncus arteriosus (HP:0001660)0.87396034
190Craniofacial hyperostosis (HP:0004493)0.86607826
191Mitral stenosis (HP:0001718)0.86183328
192Decreased circulating renin level (HP:0003351)0.86137011
193Bowel incontinence (HP:0002607)0.85862036
194Hypertensive crisis (HP:0100735)0.85795910

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT37.08942501
2CAMK1D6.91422130
3CAMK1G5.20979268
4TRIB34.83361111
5SIK14.04156466
6EPHA23.53598471
7BCKDK3.47236967
8LMTK23.13416508
9PDK32.80696345
10PDK42.80696345
11MST1R2.75616609
12NLK2.61404593
13RIPK12.61207932
14CDK122.27586979
15PRKAA21.96061858
16STK38L1.89461040
17PDK21.85214101
18FGFR21.81561978
19FGFR31.72390007
20MYLK1.68049149
21ERN11.65260740
22EPHA41.51250529
23INSRR1.47191790
24EPHB21.44845334
25EPHA31.44498447
26MAP2K21.40849551
27MELK1.39547969
28FRK1.38719294
29STK241.33556752
30PDGFRA1.33446870
31TTN1.29989113
32TGFBR21.27995132
33PRKD31.24704401
34SMG11.21889253
35PIK3CA1.17949363
36CDK91.14321121
37MAP2K11.12808118
38MET1.12001694
39FER1.11405467
40CDK61.09116087
41MAP3K61.09052318
42DDR21.08452946
43RIPK41.07132869
44JAK11.05461483
45TAF11.03911180
46PHKG21.00426975
47PHKG11.00426975
48BRD40.97351303
49TAOK30.96024160
50NTRK10.93620866
51MAP3K70.89641350
52NEK90.89112709
53PRKAA10.88045420
54PDPK10.85046747
55PTK2B0.82768223
56LATS10.82173535
57PINK10.79827098
58STK30.76020267
59LATS20.73961640
60BMPR1B0.72157353
61FGFR10.71375413
62JAK20.70782311
63TIE10.70744509
64IGF1R0.70540427
65MAP3K30.70016687
66ILK0.66987428
67TRPM70.66679530
68CAMKK20.66669463
69PAK20.65875496
70PRKCH0.65580539
71CAMK10.65543873
72KDR0.65246767
73FGFR40.64255165
74PRKACG0.62845053
75IRAK30.62480620
76RET0.61383186
77DAPK20.60843966
78PDK10.60186391
79BRSK20.59199235
80ERBB20.59124876
81CDK30.58732252
82CSK0.58503235
83GSK3A0.55170452
84MAP3K20.54825526
85MTOR0.54611034
86TESK10.54143458
87EIF2AK20.52787395
88PDGFRB0.51244370
89SRC0.51198753
90INSR0.50939230
91PRPF4B0.48331842
92PRKD10.47348296
93JAK30.46836597
94HIPK20.46669376
95MAPKAPK20.46560080
96RPS6KA50.46261219
97FES0.44415702
98MAPK70.43720803
99PRKG20.41944045
100RPS6KL10.41539801
101RPS6KC10.41539801
102ACVR1B0.40620020
103MARK20.38585968
104EPHB10.37854621
105MAPK150.37000421
106LRRK20.36306683
107CSNK1A10.35990297
108PAK40.34877338
109PRKCZ0.34856993
110BMPR20.34737030
111SGK20.33829774
112RPS6KA60.33827787
113STK380.33714701
114MAPKAPK30.33341355
115HCK0.33186168
116TYK20.32203624
117CSNK1G20.30434334
118FGR0.30327113
119MAPK120.29688924
120RPS6KB10.28833207
121PRKD20.28259706
122CLK10.27068814
123BMX0.27066680
124EEF2K0.26162981
125ABL10.26011028
126STK110.24907358
127RPS6KA20.24658289
128PKN10.24388005
129MAPK40.23903779
130MAPK110.23894238
131PIK3CG0.23823039
132PTK60.23666287
133SGK30.23167563
134PTK20.22927981
135DMPK0.22520551
136RPS6KA10.22328854
137MAP2K30.21804337
138FYN0.21638542
139GRK10.20907048
140CAMK40.20802619
141NTRK20.20481403
142ERBB30.19589070
143TNK20.19577299
144CDK50.18795975
145GRK50.18705723
146MAPK80.18163501
147BTK0.18005653
148AKT10.17602389
149ABL20.17476336
150MAPK30.17302936
151NEK60.17207537
152CSF1R0.16928963
153CSNK1G10.15999565

Predicted pathways (KEGG)

RankGene SetZ-score
1* Autoimmune thyroid disease_Homo sapiens_hsa053206.06491595
2Fatty acid biosynthesis_Homo sapiens_hsa000615.09018225
3* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.60807267
4PPAR signaling pathway_Homo sapiens_hsa033204.34663464
5Propanoate metabolism_Homo sapiens_hsa006404.23104509
6Glycerolipid metabolism_Homo sapiens_hsa005613.36124179
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.21864227
8Fatty acid metabolism_Homo sapiens_hsa012123.08260371
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.82119233
10Fatty acid degradation_Homo sapiens_hsa000712.24355862
11Pyruvate metabolism_Homo sapiens_hsa006202.19548796
12Adipocytokine signaling pathway_Homo sapiens_hsa049202.17783734
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.14942240
14AMPK signaling pathway_Homo sapiens_hsa041522.10213130
15beta-Alanine metabolism_Homo sapiens_hsa004101.95938006
16Fat digestion and absorption_Homo sapiens_hsa049751.79853750
17Caffeine metabolism_Homo sapiens_hsa002321.79763049
18Tyrosine metabolism_Homo sapiens_hsa003501.73571443
19Phenylalanine metabolism_Homo sapiens_hsa003601.60557259
20Nitrogen metabolism_Homo sapiens_hsa009101.56096948
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53920368
22Carbon metabolism_Homo sapiens_hsa012001.39673765
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33489889
24Peroxisome_Homo sapiens_hsa041461.29712870
25Insulin signaling pathway_Homo sapiens_hsa049101.29292622
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26891422
27Renin secretion_Homo sapiens_hsa049241.24600673
28Insulin resistance_Homo sapiens_hsa049311.24410217
29Staphylococcus aureus infection_Homo sapiens_hsa051501.18761900
30ECM-receptor interaction_Homo sapiens_hsa045121.17734302
31N-Glycan biosynthesis_Homo sapiens_hsa005101.16808153
32Vitamin B6 metabolism_Homo sapiens_hsa007501.11504537
33Inositol phosphate metabolism_Homo sapiens_hsa005621.10476761
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04928494
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03002115
36Lysine degradation_Homo sapiens_hsa003101.02137070
37Pentose phosphate pathway_Homo sapiens_hsa000301.00140726
38Glucagon signaling pathway_Homo sapiens_hsa049220.99670756
39Circadian rhythm_Homo sapiens_hsa047100.96961163
40Butanoate metabolism_Homo sapiens_hsa006500.96738808
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96403117
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93320320
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91198765
44Vibrio cholerae infection_Homo sapiens_hsa051100.89894007
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.88843135
46Sphingolipid metabolism_Homo sapiens_hsa006000.88408537
47Endometrial cancer_Homo sapiens_hsa052130.87015307
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86809697
49Other glycan degradation_Homo sapiens_hsa005110.74638851
50Protein digestion and absorption_Homo sapiens_hsa049740.73625815
51Focal adhesion_Homo sapiens_hsa045100.73004100
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71389938
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69969365
54Type II diabetes mellitus_Homo sapiens_hsa049300.69408008
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.68759167
56ABC transporters_Homo sapiens_hsa020100.68156699
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68008087
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62501391
59Fatty acid elongation_Homo sapiens_hsa000620.62477254
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60807661
61Amoebiasis_Homo sapiens_hsa051460.59859027
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59768266
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58575399
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57250614
65Salivary secretion_Homo sapiens_hsa049700.55861955
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.55073820
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54067542
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52780580
69Lysosome_Homo sapiens_hsa041420.52229216
70Arachidonic acid metabolism_Homo sapiens_hsa005900.51043752
71Notch signaling pathway_Homo sapiens_hsa043300.49151154
72Prostate cancer_Homo sapiens_hsa052150.48978230
73Melanoma_Homo sapiens_hsa052180.48741563
74Hippo signaling pathway_Homo sapiens_hsa043900.48388943
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48135081
76Tryptophan metabolism_Homo sapiens_hsa003800.48073700
77Linoleic acid metabolism_Homo sapiens_hsa005910.47745162
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.46767989
79Non-small cell lung cancer_Homo sapiens_hsa052230.45404097
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45043682
81Colorectal cancer_Homo sapiens_hsa052100.44624399
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44194115
83Complement and coagulation cascades_Homo sapiens_hsa046100.42719023
84Proteoglycans in cancer_Homo sapiens_hsa052050.40734367
85Estrogen signaling pathway_Homo sapiens_hsa049150.40420077
86Basal cell carcinoma_Homo sapiens_hsa052170.38712750
87Renal cell carcinoma_Homo sapiens_hsa052110.37589398
88Tight junction_Homo sapiens_hsa045300.36477542
89* cAMP signaling pathway_Homo sapiens_hsa040240.35263004
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34977502
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34742126
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34618673
93Arginine biosynthesis_Homo sapiens_hsa002200.34597969
94TGF-beta signaling pathway_Homo sapiens_hsa043500.34490182
95Toxoplasmosis_Homo sapiens_hsa051450.34145958
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.32885753
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32479135
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32224185
99Bladder cancer_Homo sapiens_hsa052190.31736546
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30907923
101* Thyroid hormone synthesis_Homo sapiens_hsa049180.30865412
102Gastric acid secretion_Homo sapiens_hsa049710.30397807
103mTOR signaling pathway_Homo sapiens_hsa041500.30382169
104Long-term potentiation_Homo sapiens_hsa047200.29874739
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29405869
106Rap1 signaling pathway_Homo sapiens_hsa040150.29109097
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28957819
108Pathways in cancer_Homo sapiens_hsa052000.28834306
109Cholinergic synapse_Homo sapiens_hsa047250.28335940
110HIF-1 signaling pathway_Homo sapiens_hsa040660.28072858
111Small cell lung cancer_Homo sapiens_hsa052220.27654975
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26830577
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26431596
114Viral myocarditis_Homo sapiens_hsa054160.25624911
115Starch and sucrose metabolism_Homo sapiens_hsa005000.25112484
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24319462
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.24132213
118Osteoclast differentiation_Homo sapiens_hsa043800.23858727
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.23771639
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.23627937
121Pancreatic secretion_Homo sapiens_hsa049720.23406550
122Fructose and mannose metabolism_Homo sapiens_hsa000510.22776265
123Dorso-ventral axis formation_Homo sapiens_hsa043200.22663802
124Pancreatic cancer_Homo sapiens_hsa052120.22648981
125Pertussis_Homo sapiens_hsa051330.21131601
126Chronic myeloid leukemia_Homo sapiens_hsa052200.20844926
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20736857
128Dilated cardiomyopathy_Homo sapiens_hsa054140.20731955
129Histidine metabolism_Homo sapiens_hsa003400.20542364
130Platelet activation_Homo sapiens_hsa046110.20274132
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20041017
132Hepatitis C_Homo sapiens_hsa051600.19522561
133Taste transduction_Homo sapiens_hsa047420.19431923
134Adherens junction_Homo sapiens_hsa045200.19425094
135Malaria_Homo sapiens_hsa051440.17946361
136Cocaine addiction_Homo sapiens_hsa050300.17318421
137Glioma_Homo sapiens_hsa052140.17222513
138Glutathione metabolism_Homo sapiens_hsa004800.16909724
139VEGF signaling pathway_Homo sapiens_hsa043700.15702264
140Ether lipid metabolism_Homo sapiens_hsa005650.15269417
141Hedgehog signaling pathway_Homo sapiens_hsa043400.14627893
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14299761
143Melanogenesis_Homo sapiens_hsa049160.12889882
144Acute myeloid leukemia_Homo sapiens_hsa052210.12560317
145Retinol metabolism_Homo sapiens_hsa008300.12075974
146Biosynthesis of amino acids_Homo sapiens_hsa012300.11976730
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11731577
148FoxO signaling pathway_Homo sapiens_hsa040680.11698194
149Thyroid cancer_Homo sapiens_hsa052160.11516247
150Tuberculosis_Homo sapiens_hsa051520.11230605
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10875282
152Bile secretion_Homo sapiens_hsa049760.10552350

Most similar genes based on co-expression Upload to Enrichr

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