TSHZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)4.69947293
2ER overload response (GO:0006983)4.05529776
3establishment of nucleus localization (GO:0040023)3.73912282
4positive regulation of oligodendrocyte differentiation (GO:0048714)3.71308833
5synaptic vesicle docking involved in exocytosis (GO:0016081)3.65970240
6endocrine pancreas development (GO:0031018)3.57718008
7COPI coating of Golgi vesicle (GO:0048205)3.50596089
8Golgi transport vesicle coating (GO:0048200)3.50596089
9synaptic vesicle maturation (GO:0016188)3.40461368
10negative regulation of erythrocyte differentiation (GO:0045647)3.28975366
11cellular potassium ion homeostasis (GO:0030007)3.26793694
12type B pancreatic cell development (GO:0003323)3.24938635
13sequestering of metal ion (GO:0051238)3.24451213
14regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20781847
15regulation of ARF protein signal transduction (GO:0032012)3.19959416
16olfactory bulb development (GO:0021772)3.09090439
17mesenchymal cell differentiation involved in renal system development (GO:2001012)3.06443642
18mesenchymal cell differentiation involved in kidney development (GO:0072161)3.06443642
19cell differentiation involved in metanephros development (GO:0072202)3.03554492
20positive regulation of fibroblast migration (GO:0010763)3.01691753
21cerebellar granule cell differentiation (GO:0021707)2.99062538
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.98279394
23positive regulation of synapse maturation (GO:0090129)2.91759082
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.90350380
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89895122
26somite development (GO:0061053)2.88770259
27cornea development in camera-type eye (GO:0061303)2.87359312
28glutamate secretion (GO:0014047)2.87042480
29synaptic vesicle exocytosis (GO:0016079)2.85600252
30negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.84806142
31ganglion development (GO:0061548)2.81891987
32auditory behavior (GO:0031223)2.80435744
33dendritic spine morphogenesis (GO:0060997)2.79628175
34potassium ion homeostasis (GO:0055075)2.79347637
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78683922
36positive regulation of hormone biosynthetic process (GO:0046886)2.76543250
37glandular epithelial cell development (GO:0002068)2.74865653
38positive regulation of glial cell differentiation (GO:0045687)2.74413998
39glandular epithelial cell differentiation (GO:0002067)2.73431783
40potassium ion import (GO:0010107)2.73225553
41sodium ion export (GO:0071436)2.72863901
42regulation of synaptic vesicle exocytosis (GO:2000300)2.72166979
43astrocyte differentiation (GO:0048708)2.69608165
44regulation of synapse maturation (GO:0090128)2.69348953
45cellular response to catecholamine stimulus (GO:0071870)2.67992517
46cellular response to monoamine stimulus (GO:0071868)2.67992517
47interleukin-1-mediated signaling pathway (GO:0070498)2.67464824
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.65672171
49positive regulation of steroid biosynthetic process (GO:0010893)2.65420347
50neutrophil activation involved in immune response (GO:0002283)2.65244394
51negative regulation of gluconeogenesis (GO:0045721)2.64288780
52positive regulation of Rap GTPase activity (GO:0032854)2.61875516
53response to peptidoglycan (GO:0032494)2.60463881
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.59956902
55regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59558381
56eye photoreceptor cell differentiation (GO:0001754)2.57392794
57photoreceptor cell differentiation (GO:0046530)2.57392794
58cytoplasmic mRNA processing body assembly (GO:0033962)2.57006408
59positive regulation of cellular amide metabolic process (GO:0034250)2.56944397
60COPII vesicle coating (GO:0048208)2.54453226
61neurotransmitter secretion (GO:0007269)2.54391816
62activated T cell proliferation (GO:0050798)2.54353236
63regulation of short-term neuronal synaptic plasticity (GO:0048172)2.53678573
64regulation of male gonad development (GO:2000018)2.53178335
65production of molecular mediator involved in inflammatory response (GO:0002532)2.53094272
66amyloid precursor protein catabolic process (GO:0042987)2.51831248
67sequestering of actin monomers (GO:0042989)2.51519714
68peptide hormone processing (GO:0016486)2.50989321
69cellular response to nicotine (GO:0071316)2.49744115
70response to monoamine (GO:0071867)2.48228935
71response to catecholamine (GO:0071869)2.48228935
72negative regulation of glycogen biosynthetic process (GO:0045719)2.46975116
73exocrine pancreas development (GO:0031017)2.46423061
74locomotory exploration behavior (GO:0035641)2.46398584
75membrane protein ectodomain proteolysis (GO:0006509)2.45648641
76cellular response to epinephrine stimulus (GO:0071872)2.45062785
77limb bud formation (GO:0060174)2.44348814
78layer formation in cerebral cortex (GO:0021819)2.43843661
79regulation of vitamin D biosynthetic process (GO:0060556)2.42517831
80negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.42350320
81cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.41262566
82ionotropic glutamate receptor signaling pathway (GO:0035235)2.41221303
83cerebellar Purkinje cell layer development (GO:0021680)2.39425622
84detection of molecule of bacterial origin (GO:0032490)2.39258741
85negative regulation of glycogen metabolic process (GO:0070874)2.38978212
86regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.38943010
87metanephric mesenchyme development (GO:0072075)2.37091471
88detection of calcium ion (GO:0005513)2.37048195
89neurotransmitter-gated ion channel clustering (GO:0072578)2.36966657
90negative regulation of neurotransmitter secretion (GO:0046929)2.36922081
91energy homeostasis (GO:0097009)2.36603265
92peripheral nervous system neuron development (GO:0048935)2.36073693
93regulation of respiratory system process (GO:0044065)2.36051228
94regulation of synaptic vesicle transport (GO:1902803)2.35940030
95regulation of glutamate receptor signaling pathway (GO:1900449)2.35397765
96cellular response to vitamin D (GO:0071305)2.34554525
97nucleus localization (GO:0051647)2.33982164
98regulation of T-helper 1 cell differentiation (GO:0045625)2.33283711
99neural tube formation (GO:0001841)2.32417287
100mechanosensory behavior (GO:0007638)2.31728277
101respiratory burst (GO:0045730)2.31057585
102regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.29626499
103negative regulation of type 2 immune response (GO:0002829)2.29396226
104response to lipoprotein particle (GO:0055094)2.29091224
105histone H3-K4 trimethylation (GO:0080182)2.26714761
106positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.26702024
107regulation of type B pancreatic cell apoptotic process (GO:2000674)2.26484280
108regulation of chromatin binding (GO:0035561)2.26079619
109regulation of oligodendrocyte differentiation (GO:0048713)2.25585325
110G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.25130252
111retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.24482213
112eosinophil chemotaxis (GO:0048245)2.24213690
113membrane protein proteolysis (GO:0033619)2.24033691
114urinary tract smooth muscle contraction (GO:0014848)2.23822659
115detection of other organism (GO:0098543)2.23106519
116regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.23040889
117regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.22662512
118hydrogen peroxide biosynthetic process (GO:0050665)2.21046028
119neutrophil activation (GO:0042119)2.20321897
120positive regulation of protein dephosphorylation (GO:0035307)2.20016000
121postsynaptic membrane organization (GO:0001941)2.19980721
122positive regulation of dendritic spine development (GO:0060999)2.19508257
123regulation of extracellular matrix disassembly (GO:0010715)2.19458864
124amyloid precursor protein metabolic process (GO:0042982)2.18009519
125axonal fasciculation (GO:0007413)2.17786308
126mesenchymal cell differentiation (GO:0048762)2.17387838
127sex determination (GO:0007530)2.17236995
128regulation of Rap GTPase activity (GO:0032317)2.17144276
129androgen biosynthetic process (GO:0006702)2.17043517
130granulocyte activation (GO:0036230)2.16229092
131nucleoside diphosphate catabolic process (GO:0009134)2.15683319
132positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.15527282
133cytoskeletal anchoring at plasma membrane (GO:0007016)2.15046479
134centriole replication (GO:0007099)2.14419316
135positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.14387491
136regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.13697752
137insulin secretion (GO:0030073)2.13489830
138L-amino acid import (GO:0043092)2.12782738
139suckling behavior (GO:0001967)2.12020876
140negative regulation of glucose transport (GO:0010829)2.11732495
141kidney mesenchyme development (GO:0072074)2.11002858
142response to muramyl dipeptide (GO:0032495)2.10778689
143central nervous system myelination (GO:0022010)2.10663176
144axon ensheathment in central nervous system (GO:0032291)2.10663176
145regulation of neuronal synaptic plasticity (GO:0048168)2.10294415
146positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.10041601
147negative regulation of glucose import (GO:0046325)2.09760130
148negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.08974329
149response to parathyroid hormone (GO:0071107)2.08823149
150positive regulation by symbiont of host defense response (GO:0052509)2.08719303
151modulation by symbiont of host defense response (GO:0052031)2.08719303
152modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.08719303
153modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.08719303
154positive regulation by organism of defense response of other organism involved in symbiotic interact2.08719303
155modulation by symbiont of host immune response (GO:0052553)2.08719303
156negative regulation of JUN kinase activity (GO:0043508)2.08425903
157regulation of synapse structural plasticity (GO:0051823)2.08395066
158peptidyl-tyrosine autophosphorylation (GO:0038083)2.08046236
159regulation of vitamin metabolic process (GO:0030656)2.07995001
160positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.07974350
161regulation of glomerulus development (GO:0090192)2.07470416
162dopamine receptor signaling pathway (GO:0007212)2.05513505
163regulation of respiratory gaseous exchange (GO:0043576)2.05363761
164positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.05282334
165neural crest cell development (GO:0014032)2.05210344
166embryonic epithelial tube formation (GO:0001838)2.02754176
167viral protein processing (GO:0019082)2.02720410
168regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.02687866
169negative regulation of catenin import into nucleus (GO:0035414)2.02472858
170activation of protein kinase A activity (GO:0034199)2.02059305
171cell communication by electrical coupling (GO:0010644)2.01635708
172cellular sodium ion homeostasis (GO:0006883)2.01440214
173superoxide anion generation (GO:0042554)2.00568236
174response to epinephrine (GO:0071871)2.00379538
175neuron remodeling (GO:0016322)2.00195941
176embryonic retina morphogenesis in camera-type eye (GO:0060059)1.99985435
177cellular response to vascular endothelial growth factor stimulus (GO:0035924)1.99595392
178peptidyl-threonine phosphorylation (GO:0018107)1.99460617
179cell differentiation in hindbrain (GO:0021533)1.99155730
180peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)1.99144791
181regulation of ARF GTPase activity (GO:0032312)1.99067615
182positive regulation of synaptic transmission, glutamatergic (GO:0051968)1.99045974
183regulation of long-term neuronal synaptic plasticity (GO:0048169)1.97798385
184epithelial cell fate commitment (GO:0072148)1.97329532
185response to auditory stimulus (GO:0010996)1.95436509
186positive regulation of glycogen biosynthetic process (GO:0045725)1.95338285
187positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003601.95204928
188exploration behavior (GO:0035640)1.94814777
189positive regulation of CREB transcription factor activity (GO:0032793)1.94554362
190positive regulation of membrane potential (GO:0045838)1.93674004
191neuron recognition (GO:0008038)1.93477475
192synaptic vesicle endocytosis (GO:0048488)1.93281510
193cerebellar Purkinje cell differentiation (GO:0021702)1.92376306
194negative regulation of cAMP-mediated signaling (GO:0043951)1.92362799
195cellular response to fluid shear stress (GO:0071498)1.91861232
196cartilage development involved in endochondral bone morphogenesis (GO:0060351)1.91811118
197neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)1.91381751
198regulation of axon extension involved in axon guidance (GO:0048841)1.90865344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59267342
2CDX2_19796622_ChIP-Seq_MESCs_Mouse2.25397652
3DROSHA_22980978_ChIP-Seq_HELA_Human2.18906091
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.14141936
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14043128
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.13901430
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12158084
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11558482
9ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92965263
10* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92039699
11WT1_19549856_ChIP-ChIP_CCG9911_Human1.90020154
12TRIM28_21343339_ChIP-Seq_HEK293_Human1.87461377
13PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79791068
14KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79723665
15EZH2_22144423_ChIP-Seq_EOC_Human1.75686172
16IGF1R_20145208_ChIP-Seq_DFB_Human1.73954602
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.73142701
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67403280
19KDM2B_26808549_Chip-Seq_K562_Human1.65888557
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65836676
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65571830
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.65564775
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64466294
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.62143813
25* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58940361
26* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56536616
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.55984108
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55894949
29* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54535390
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53184338
31REST_21632747_ChIP-Seq_MESCs_Mouse1.51869865
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50352064
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.49798428
34AHR_22903824_ChIP-Seq_MCF-7_Human1.49344217
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48545214
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48545214
37VDR_22108803_ChIP-Seq_LS180_Human1.45509774
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.45201123
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44051459
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42156998
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41535579
42* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40670649
43* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40670649
44* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40288076
45TP53_18474530_ChIP-ChIP_U2OS_Human1.40214448
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.40005990
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38329307
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37877263
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37503165
50KDM2B_26808549_Chip-Seq_DND41_Human1.36948091
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.36854884
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36519633
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36132233
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35071560
55* TP53_20018659_ChIP-ChIP_R1E_Mouse1.34579366
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34402679
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31911445
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29624840
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29140930
60* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28562792
61* KDM2B_26808549_Chip-Seq_JURKAT_Human1.28193809
62* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27600400
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27310028
64* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25858113
65* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25506514
66GBX2_23144817_ChIP-Seq_PC3_Human1.25116631
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23742953
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23692678
69* SOX2_20726797_ChIP-Seq_SW620_Human1.22873562
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22755315
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.21777202
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21364918
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19007604
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18448078
75* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18377019
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18245533
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.17891565
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17595631
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16944883
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16911284
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16878417
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16571318
83* EP300_21415370_ChIP-Seq_HL-1_Mouse1.16423473
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16370890
85CJUN_26792858_Chip-Seq_BT549_Human1.15141468
86* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13898714
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13890722
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13690366
89VDR_24787735_ChIP-Seq_THP-1_Human1.11390626
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10097975
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.09519782
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09229565
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08900301
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.08536037
95TAF15_26573619_Chip-Seq_HEK293_Human1.07596454
96BCAT_22108803_ChIP-Seq_LS180_Human1.07561533
97* TCF7_22412390_ChIP-Seq_EML_Mouse1.07509227
98SMAD4_21799915_ChIP-Seq_A2780_Human1.06941004
99CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06056515
100LXR_22292898_ChIP-Seq_THP-1_Human1.05499827
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.04386067
102* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03575232
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01889494
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.00969538
105FOXA1_25552417_ChIP-Seq_VCAP_Human1.00922283
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00821531
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00614093
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00361366
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00111679
110ER_23166858_ChIP-Seq_MCF-7_Human0.99625609
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99322953
112P300_19829295_ChIP-Seq_ESCs_Human0.98842366
113AR_19668381_ChIP-Seq_PC3_Human0.98707421
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98582616
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98486694
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97986565
117* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96500495
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95862168
119AR_21572438_ChIP-Seq_LNCaP_Human0.95058029
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94580967
121P53_22387025_ChIP-Seq_ESCs_Mouse0.94314350
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.94234770
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93859889
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93640437
125IRF8_27001747_Chip-Seq_BMDM_Mouse0.93567505
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93544265
127CDX2_20551321_ChIP-Seq_CACO-2_Human0.93380820
128* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93244960
129* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93185828
130* RING1B_27294783_Chip-Seq_NPCs_Mouse0.92897504
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92720912
132STAT3_23295773_ChIP-Seq_U87_Human0.92251170
133IRF8_21731497_ChIP-ChIP_J774_Mouse0.91212739
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90835926
135FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90807168
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90445255
137RNF2_27304074_Chip-Seq_NSC_Mouse0.90350472
138RUNX_20019798_ChIP-Seq_JUKART_Human0.89771219
139* SOX2_21211035_ChIP-Seq_LN229_Gbm0.89499138
140ISL1_27105846_Chip-Seq_CPCs_Mouse0.88860893
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88690764
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88093909
143OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87477115
144FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86424078
145ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86246104
146GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85316784
147CTCF_27219007_Chip-Seq_Bcells_Human0.83427356
148TP53_16413492_ChIP-PET_HCT116_Human0.83095430
149ERG_21242973_ChIP-ChIP_JURKAT_Human0.82268226
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81216091
151TET1_21490601_ChIP-Seq_MESCs_Mouse0.81206155
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.80046103
153TBX20_22080862_ChIP-Seq_HEART_Mouse0.78484676
154TBX20_22328084_ChIP-Seq_HEART_Mouse0.78484676
155* TP53_23651856_ChIP-Seq_MEFs_Mouse0.78237576
156* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.77771882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.82689831
2MP0003195_calcinosis3.65987204
3MP0002877_abnormal_melanocyte_morpholog3.50358468
4MP0008789_abnormal_olfactory_epithelium3.48510583
5MP0003787_abnormal_imprinting2.69255294
6MP0006054_spinal_hemorrhage2.62491494
7MP0005423_abnormal_somatic_nervous2.53584393
8MP0005499_abnormal_olfactory_system2.48333092
9MP0005394_taste/olfaction_phenotype2.48333092
10MP0002693_abnormal_pancreas_physiology2.44435071
11MP0003635_abnormal_synaptic_transmissio2.44192920
12MP0004043_abnormal_pH_regulation2.42794910
13MP0000678_abnormal_parathyroid_gland2.39666511
14MP0005645_abnormal_hypothalamus_physiol2.36192992
15MP0004270_analgesia2.27468676
16MP0001958_emphysema2.24113663
17MP0003724_increased_susceptibility_to2.23767589
18MP0010386_abnormal_urinary_bladder2.20746918
19MP0001944_abnormal_pancreas_morphology2.13721966
20MP0002064_seizures2.10718847
21MP0002063_abnormal_learning/memory/cond2.06851330
22MP0003879_abnormal_hair_cell1.99179972
23MP0005379_endocrine/exocrine_gland_phen1.89848303
24MP0005257_abnormal_intraocular_pressure1.89769605
25MP0002896_abnormal_bone_mineralization1.89656100
26MP0004130_abnormal_muscle_cell1.87608450
27MP0003300_gastrointestinal_ulcer1.87361720
28MP0002138_abnormal_hepatobiliary_system1.84291911
29MP0001502_abnormal_circadian_rhythm1.83608548
30MP0008569_lethality_at_weaning1.80104663
31MP0004885_abnormal_endolymph1.77816660
32MP0003880_abnormal_central_pattern1.69561598
33MP0001501_abnormal_sleep_pattern1.69195240
34MP0003279_aneurysm1.69047344
35MP0009250_abnormal_appendicular_skeleto1.67457700
36MP0002998_abnormal_bone_remodeling1.65938342
37MP0002876_abnormal_thyroid_physiology1.62302256
38MP0002148_abnormal_hypersensitivity_rea1.61624260
39MP0009745_abnormal_behavioral_response1.59604355
40MP0003123_paternal_imprinting1.57753781
41MP0005220_abnormal_exocrine_pancreas1.57144886
42MP0000003_abnormal_adipose_tissue1.56656903
43MP0001440_abnormal_grooming_behavior1.55144803
44MP0002272_abnormal_nervous_system1.54691834
45MP0009046_muscle_twitch1.53673098
46MP0000013_abnormal_adipose_tissue1.51707083
47MP0003122_maternal_imprinting1.49979280
48MP0003705_abnormal_hypodermis_morpholog1.41999413
49MP0001486_abnormal_startle_reflex1.41536542
50MP0000613_abnormal_salivary_gland1.40775218
51MP0003690_abnormal_glial_cell1.40520414
52MP0002572_abnormal_emotion/affect_behav1.39958494
53MP0002108_abnormal_muscle_morphology1.38745887
54MP0009780_abnormal_chondrocyte_physiolo1.37811276
55MP0004142_abnormal_muscle_tone1.36901762
56MP0002938_white_spotting1.35741669
57MP0003633_abnormal_nervous_system1.34692277
58MP0002009_preneoplasia1.30764988
59MP0005000_abnormal_immune_tolerance1.30733808
60MP0003329_amyloid_beta_deposits1.29411074
61MP0002928_abnormal_bile_duct1.28225614
62MP0000778_abnormal_nervous_system1.27699417
63MP0003183_abnormal_peptide_metabolism1.27589536
64MP0000462_abnormal_digestive_system1.26290309
65MP0005409_darkened_coat_color1.23154636
66MP0001851_eye_inflammation1.21738103
67MP0004924_abnormal_behavior1.21616512
68MP0005386_behavior/neurological_phenoty1.21616512
69MP0005275_abnormal_skin_tensile1.21038267
70MP0002734_abnormal_mechanical_nocicepti1.20968070
71MP0000566_synostosis1.20040512
72MP0003303_peritoneal_inflammation1.19373207
73MP0010368_abnormal_lymphatic_system1.19245052
74MP0001970_abnormal_pain_threshold1.18826890
75MP0001879_abnormal_lymphatic_vessel1.18239741
76MP0000955_abnormal_spinal_cord1.17240351
77MP0002233_abnormal_nose_morphology1.17213856
78* MP0002249_abnormal_larynx_morphology1.14953695
79MP0002067_abnormal_sensory_capabilities1.14284465
80MP0003942_abnormal_urinary_system1.12983138
81MP0002419_abnormal_innate_immunity1.12253795
82MP0003795_abnormal_bone_structure1.11908943
83MP0002909_abnormal_adrenal_gland1.11881668
84MP0001270_distended_abdomen1.11401552
85MP0002971_abnormal_brown_adipose1.11118379
86MP0001346_abnormal_lacrimal_gland1.10679163
87MP0003385_abnormal_body_wall1.09448910
88MP0000538_abnormal_urinary_bladder1.09176954
89MP0005646_abnormal_pituitary_gland1.08848782
90MP0001835_abnormal_antigen_presentation1.08602470
91MP0003091_abnormal_cell_migration1.08224446
92MP0009785_altered_susceptibility_to1.07712709
93MP0005387_immune_system_phenotype1.07644000
94MP0001790_abnormal_immune_system1.07644000
95MP0002837_dystrophic_cardiac_calcinosis1.05234018
96MP0002557_abnormal_social/conspecific_i1.04634846
97MP0005408_hypopigmentation1.04522261
98MP0000569_abnormal_digit_pigmentation1.02351782
99MP0005310_abnormal_salivary_gland1.01733692
100MP0005503_abnormal_tendon_morphology0.99801123
101MP0005187_abnormal_penis_morphology0.99700442
102MP0000372_irregular_coat_pigmentation0.99419373
103MP0002735_abnormal_chemical_nociception0.99118396
104MP0003172_abnormal_lysosome_physiology0.99001743
105MP0001188_hyperpigmentation0.98600072
106MP0000920_abnormal_myelination0.98050916
107MP0002115_abnormal_skeleton_extremities0.96663414
108MP0000516_abnormal_urinary_system0.95491803
109MP0005367_renal/urinary_system_phenotyp0.95491803
110MP0000685_abnormal_immune_system0.95238012
111MP0003631_nervous_system_phenotype0.93346186
112MP0004381_abnormal_hair_follicle0.93246234
113MP0002733_abnormal_thermal_nociception0.92674383
114MP0002163_abnormal_gland_morphology0.92461655
115MP0000647_abnormal_sebaceous_gland0.92121997
116MP0002295_abnormal_pulmonary_circulatio0.91592735
117MP0002168_other_aberrant_phenotype0.91449829
118MP0003959_abnormal_lean_body0.90844618
119MP0000631_abnormal_neuroendocrine_gland0.90739938
120MP0000767_abnormal_smooth_muscle0.89310356
121MP0004742_abnormal_vestibular_system0.89127366
122MP0001340_abnormal_eyelid_morphology0.88802726
123MP0005508_abnormal_skeleton_morphology0.88729962
124MP0001984_abnormal_olfaction0.88427093
125MP0002638_abnormal_pupillary_reflex0.88333043
126MP0002933_joint_inflammation0.88332605
127MP0002066_abnormal_motor_capabilities/c0.88037897
128MP0001533_abnormal_skeleton_physiology0.87492577
129MP0001177_atelectasis0.87280828
130MP0004811_abnormal_neuron_physiology0.86862451
131MP0001664_abnormal_digestion0.86696821
132MP0004510_myositis0.85435424
133MP0003436_decreased_susceptibility_to0.84958092
134MP0004145_abnormal_muscle_electrophysio0.84778415
135MP0002882_abnormal_neuron_morphology0.84568637
136MP0008961_abnormal_basal_metabolism0.84116485
137MP0002184_abnormal_innervation0.84114723
138MP0003283_abnormal_digestive_organ0.83980001
139MP0005171_absent_coat_pigmentation0.83647151
140MP0000534_abnormal_ureter_morphology0.82889930
141MP0000015_abnormal_ear_pigmentation0.82660996
142MP0001485_abnormal_pinna_reflex0.81992265
143MP0005390_skeleton_phenotype0.81971352
144MP0002078_abnormal_glucose_homeostasis0.81658590
145MP0005388_respiratory_system_phenotype0.79570135
146MP0002133_abnormal_respiratory_system0.79570135
147MP0005535_abnormal_body_temperature0.79558293
148MP0000733_abnormal_muscle_development0.79333801
149MP0003045_fibrosis0.78952581
150MP0005025_abnormal_response_to0.78801826
151* MP0000163_abnormal_cartilage_morphology0.78543876
152MP0005248_abnormal_Harderian_gland0.78505599
153MP0002109_abnormal_limb_morphology0.78073372
154MP0000470_abnormal_stomach_morphology0.77374432
155MP0008438_abnormal_cutaneous_collagen0.77364380
156MP0002113_abnormal_skeleton_development0.76919506
157* MP0002116_abnormal_craniofacial_bone0.76895738
158MP0005595_abnormal_vascular_smooth0.76723186
159MP0003937_abnormal_limbs/digits/tail_de0.76024764
160MP0001348_abnormal_lacrimal_gland0.75703243
161MP0009764_decreased_sensitivity_to0.75663052
162MP0006082_CNS_inflammation0.75596183
163* MP0003755_abnormal_palate_morphology0.75526545
164MP0000681_abnormal_thyroid_gland0.75414360
165MP0004134_abnormal_chest_morphology0.74984234
166MP0001299_abnormal_eye_distance/0.74962155
167* MP0000049_abnormal_middle_ear0.74660559
168* MP0001943_abnormal_respiration0.73371774
169MP0005375_adipose_tissue_phenotype0.73306941
170MP0002098_abnormal_vibrissa_morphology0.73296825
171MP0003828_pulmonary_edema0.72898881
172MP0002060_abnormal_skin_morphology0.72180785
173MP0003634_abnormal_glial_cell0.71978868
174MP0003868_abnormal_feces_composition0.69078274

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.17459530
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.76206483
3Recurrent bacterial skin infections (HP:0005406)3.75988098
4Recurrent abscess formation (HP:0002722)3.72789796
5Insulin-resistant diabetes mellitus (HP:0000831)3.49633363
6Hyperinsulinemic hypoglycemia (HP:0000825)3.28167573
7Symptomatic seizures (HP:0011145)3.27102166
8Eczematoid dermatitis (HP:0000976)3.20971550
9Hypothermia (HP:0002045)3.20581183
10Hypoglycemic seizures (HP:0002173)3.09515854
11Pancreatic islet-cell hyperplasia (HP:0004510)3.02559855
12Hyperglycemia (HP:0003074)2.90750489
13Abnormal sex determination (HP:0012244)2.88727103
14Sex reversal (HP:0012245)2.88727103
15Papilledema (HP:0001085)2.88174017
16Abnormality of calcium-phosphate metabolism (HP:0100530)2.74703188
17True hermaphroditism (HP:0010459)2.74604298
18Protrusio acetabuli (HP:0003179)2.72644248
19Congenital sensorineural hearing impairment (HP:0008527)2.63904211
20Prostate neoplasm (HP:0100787)2.62253326
21Recurrent gram-negative bacterial infections (HP:0005420)2.62121772
22Asymmetry of the thorax (HP:0001555)2.60243062
23Action tremor (HP:0002345)2.58214004
24Febrile seizures (HP:0002373)2.52428836
25Macroorchidism (HP:0000053)2.47452115
26Abnormality of binocular vision (HP:0011514)2.45503337
27Diplopia (HP:0000651)2.45503337
28Cerebral aneurysm (HP:0004944)2.44477482
29Metaphyseal dysplasia (HP:0100255)2.42967486
30Annular pancreas (HP:0001734)2.41599252
31Overgrowth (HP:0001548)2.41502056
32Shallow orbits (HP:0000586)2.38410351
33Abnormality of the pancreatic islet cells (HP:0006476)2.38386854
34Abnormality of endocrine pancreas physiology (HP:0012093)2.38386854
35Sleep apnea (HP:0010535)2.36931877
36Focal seizures (HP:0007359)2.36915452
37Unilateral renal agenesis (HP:0000122)2.36013147
38Hypercortisolism (HP:0001578)2.35871505
39Pancreatic fibrosis (HP:0100732)2.34075509
40Aortic aneurysm (HP:0004942)2.33365587
41Truncal ataxia (HP:0002078)2.33187372
42Supranuclear gaze palsy (HP:0000605)2.31464415
43Hypokalemia (HP:0002900)2.31221273
44Progressive cerebellar ataxia (HP:0002073)2.31144000
45Abnormal eating behavior (HP:0100738)2.27234503
46Genetic anticipation (HP:0003743)2.25288493
47Lip pit (HP:0100267)2.23862696
48Blue irides (HP:0000635)2.23333647
49Neonatal short-limb short stature (HP:0008921)2.22095232
50Vascular tortuosity (HP:0004948)2.21016438
51Hyperparathyroidism (HP:0000843)2.20893058
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20734167
53Bladder diverticulum (HP:0000015)2.20172362
54Gingivitis (HP:0000230)2.19027043
55Retrobulbar optic neuritis (HP:0100654)2.18815308
56Optic neuritis (HP:0100653)2.18815308
57Large for gestational age (HP:0001520)2.18759610
58Testicular neoplasm (HP:0010788)2.16857777
59Agitation (HP:0000713)2.16664138
60Occipital encephalocele (HP:0002085)2.13664901
61Hyperphosphatemia (HP:0002905)2.13254054
62Dysmetric saccades (HP:0000641)2.10805264
63Turricephaly (HP:0000262)2.10382319
64Epileptic encephalopathy (HP:0200134)2.09616010
65Ankle clonus (HP:0011448)2.09578179
66Cystic liver disease (HP:0006706)2.08908970
67Abnormality of the aortic arch (HP:0012303)2.08377115
68Enlarged penis (HP:0000040)2.07784574
69Cerebral inclusion bodies (HP:0100314)2.07682632
70Hypoglycemic coma (HP:0001325)2.06488831
71Difficulty running (HP:0009046)2.05570803
72Mediastinal lymphadenopathy (HP:0100721)2.05172869
73Mitral regurgitation (HP:0001653)2.04307428
74Hyperacusis (HP:0010780)2.04194145
75Medial flaring of the eyebrow (HP:0010747)2.03470562
76Spinal cord lesions (HP:0100561)2.02709769
77Syringomyelia (HP:0003396)2.02709769
78Aneurysm (HP:0002617)2.01681890
79Xerostomia (HP:0000217)2.01630151
80Spinal canal stenosis (HP:0003416)2.01615719
81Focal motor seizures (HP:0011153)2.00636728
82Recurrent skin infections (HP:0001581)2.00357046
83Myokymia (HP:0002411)2.00313063
84Mucopolysacchariduria (HP:0008155)1.99912880
85Urinary glycosaminoglycan excretion (HP:0003541)1.99912880
86Thoracolumbar scoliosis (HP:0002944)1.97886044
87Increased variability in muscle fiber diameter (HP:0003557)1.96625801
88Hemiparesis (HP:0001269)1.96210510
89Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.96002725
90Aortic dissection (HP:0002647)1.95510693
91Narrow palate (HP:0000189)1.94891239
92Bowel diverticulosis (HP:0005222)1.94631308
93Decreased circulating renin level (HP:0003351)1.93724743
94Enlarged kidneys (HP:0000105)1.91704861
95Genu recurvatum (HP:0002816)1.91085722
96Hypoventilation (HP:0002791)1.89869628
97Hemiplegia (HP:0002301)1.89564326
98Broad metatarsal (HP:0001783)1.88982725
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88370623
100Abnormality of the phalanges of the hallux (HP:0010057)1.88064323
101Popliteal pterygium (HP:0009756)1.87914516
102Short middle phalanx of the 5th finger (HP:0004220)1.87891406
103Acne (HP:0001061)1.87401435
104Atonic seizures (HP:0010819)1.86376462
105Genital tract atresia (HP:0001827)1.85986236
106Absence seizures (HP:0002121)1.85478572
107Abnormal pancreas size (HP:0012094)1.85457924
108Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85074525
109Abnormality of polysaccharide metabolism (HP:0011012)1.85074525
110Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85074525
111Aplasia/Hypoplasia of the fovea (HP:0008060)1.84725506
112Hypoplasia of the fovea (HP:0007750)1.84725506
113Submucous cleft hard palate (HP:0000176)1.84701056
114Orchitis (HP:0100796)1.84373415
115Palpebral edema (HP:0100540)1.84009339
116Hyperextensible skin (HP:0000974)1.83221238
117Cone-rod dystrophy (HP:0000548)1.82985517
118Metabolic alkalosis (HP:0200114)1.82229675
119Deep palmar crease (HP:0006191)1.82145814
120Type 1 muscle fiber predominance (HP:0003803)1.82120503
121Athetosis (HP:0002305)1.81503851
122Abnormality of the frontal sinuses (HP:0002687)1.81324128
123Abnormality of potassium homeostasis (HP:0011042)1.81200920
124Anosmia (HP:0000458)1.78770529
125Absent eyebrow (HP:0002223)1.77883993
126Osteomalacia (HP:0002749)1.77527446
127Arterial tortuosity (HP:0005116)1.77507856
128Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.76827163
129Hypoplasia of the iris (HP:0007676)1.76603852
130Megalencephaly (HP:0001355)1.76401249
131Dysostosis multiplex (HP:0000943)1.75340362
132Mild short stature (HP:0003502)1.75292513
133Vacuolated lymphocytes (HP:0001922)1.74949952
134Broad-based gait (HP:0002136)1.73600989
135Growth hormone excess (HP:0000845)1.73290575
136Ocular albinism (HP:0001107)1.73160492
137Supernumerary nipples (HP:0002558)1.73113438
138Dislocated radial head (HP:0003083)1.73042200
139Laryngomalacia (HP:0001601)1.71962863
140Epileptiform EEG discharges (HP:0011182)1.71507222
141Wormian bones (HP:0002645)1.71440713
142Wide anterior fontanel (HP:0000260)1.71280479
143Spondylolisthesis (HP:0003302)1.69810760
144Aplasia/hypoplasia of the uterus (HP:0008684)1.69623591
145Bell-shaped thorax (HP:0001591)1.69512395
146Visceral angiomatosis (HP:0100761)1.69405746
147Lower limb asymmetry (HP:0100559)1.69378510
148Ventricular fibrillation (HP:0001663)1.69199708
149Exocrine pancreatic insufficiency (HP:0001738)1.68861382
150Thin bony cortex (HP:0002753)1.68411879
151Decreased central vision (HP:0007663)1.67881164
152Vaginal atresia (HP:0000148)1.67805902
153Abnormality of the parietal bone (HP:0002696)1.67617796
154Hypokalemic alkalosis (HP:0001949)1.66821316
155Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.66580180
156Neurofibrillary tangles (HP:0002185)1.66455657
157Thick nail (HP:0001805)1.66402852
158Striae distensae (HP:0001065)1.66389928
159Fragile skin (HP:0001030)1.66111904
160Molar tooth sign on MRI (HP:0002419)1.65988623
161Abnormality of midbrain morphology (HP:0002418)1.65988623
162Increased circulating renin level (HP:0000848)1.65379483
163Menstrual irregularities (HP:0000858)1.65093790
164Gait imbalance (HP:0002141)1.64456581
165Depression (HP:0000716)1.64452263
166Germ cell neoplasia (HP:0100728)1.63758903
167Torticollis (HP:0000473)1.63589059
168EEG with generalized epileptiform discharges (HP:0011198)1.63005361
169Truncal obesity (HP:0001956)1.62946826
170Male pseudohermaphroditism (HP:0000037)1.62810189
171Abnormality of the left ventricular outflow tract (HP:0011103)1.62741859
172Subaortic stenosis (HP:0001682)1.62741859
173Dysdiadochokinesis (HP:0002075)1.62518895
174Abnormality of macrophages (HP:0004311)1.62362182
175Mitral valve prolapse (HP:0001634)1.62158218
176Congenital hepatic fibrosis (HP:0002612)1.62063168
177Abnormality of renin-angiotensin system (HP:0000847)1.62006363
178Craniofacial hyperostosis (HP:0004493)1.61356597
179Congenital primary aphakia (HP:0007707)1.61176416
180Abnormality of the radial head (HP:0003995)1.61097678
181Impaired smooth pursuit (HP:0007772)1.60193377
182Cranial hyperostosis (HP:0004437)1.59729269
183Cupped ear (HP:0000378)1.59565632
184Peripheral hypomyelination (HP:0007182)1.59163788
185Round face (HP:0000311)1.59109816
186Aplasia/Hypoplasia of the lens (HP:0008063)1.58952330
187Sacral dimple (HP:0000960)1.58900029
188Abnormality of chloride homeostasis (HP:0011422)1.57951475
189Ulnar bowing (HP:0003031)1.57737059
190Vasculitis (HP:0002633)1.57701950
191Buphthalmos (HP:0000557)1.57630873
192Venous insufficiency (HP:0005293)1.57509345
193Obstructive lung disease (HP:0006536)1.57121403
194Premature rupture of membranes (HP:0001788)1.57011566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB34.62087695
2INSRR4.33384101
3BMPR23.71056422
4PRPF4B2.89308811
5MARK12.63953784
6TAOK32.58380891
7RIPK12.50884330
8IRAK42.33925426
9NTRK32.26807034
10MAPK152.25301694
11MAP3K142.23883331
12AKT32.22478934
13IRAK32.02715355
14TRIB31.99180758
15HIPK21.83072112
16WNK41.81833660
17BMPR1B1.73126405
18FRK1.68442805
19PAK61.67594655
20NUAK11.66756090
21TXK1.62531694
22SGK31.59292121
23MARK21.58326369
24EEF2K1.54561786
25FES1.53940578
26EPHB11.51466373
27MAP3K21.49898376
28IRAK11.49691579
29DAPK21.47157695
30EPHA31.43996367
31MST1R1.42036025
32KSR21.36518705
33JAK31.36402590
34CASK1.35255045
35ICK1.34516813
36PASK1.33579046
37MET1.32591759
38STK381.27419978
39PLK41.25994875
40RIPK41.24263994
41STK391.23692250
42NLK1.23162822
43WNK11.20235351
44TYRO31.18657282
45MAPK121.14679083
46NEK91.14551043
47IKBKE1.12721978
48CAMKK11.12585717
49SIK31.10348748
50PDGFRA1.08410860
51MAP3K91.08122208
52RPS6KA21.03955327
53CHUK1.03464017
54IRAK21.02345374
55TAOK11.01533114
56PHKG20.99004071
57PHKG10.99004071
58MAP3K70.98529199
59DYRK1B0.96753321
60MAP3K130.92163334
61MAP2K20.91180377
62YES10.91172305
63TRPM70.90982824
64CDK120.90033515
65LATS10.89136346
66PRKCH0.88907948
67CSNK1A1L0.88900010
68SGK4940.86396696
69SGK2230.86396696
70CAMK1D0.86020356
71MAPK130.85512100
72PBK0.83411120
73TBK10.82644581
74SGK10.81694991
75PIM20.81667639
76PDGFRB0.77959289
77STK110.76673373
78SIK10.76585645
79PRKCE0.76420566
80MAPK70.75944682
81FGFR40.75215132
82DDR20.72819324
83PKN10.72108940
84ERN10.71427545
85MTOR0.71107740
86CDK50.69823277
87PIK3CA0.69484709
88CAMK40.68879032
89TTN0.68177550
90MINK10.67941777
91ROCK10.67710109
92JAK10.66977926
93NTRK10.66195620
94CAMK2D0.65250208
95PDPK10.65121171
96PRKCQ0.64887617
97TIE10.64688485
98MUSK0.64645925
99SIK20.64525115
100MAPKAPK50.64288710
101PRKD30.64093129
102NEK60.63852661
103CAMK10.63654547
104TYK20.62333819
105RPS6KA60.62128393
106PAK30.61576591
107FGFR20.60150381
108SGK20.59692352
109MYLK0.58981766
110PDK10.58844437
111MST40.58827330
112PLK20.58029031
113CSK0.57847384
114BCR0.57217376
115CDK90.56360228
116EPHB20.56289958
117PRKD20.56209262
118DYRK1A0.55058323
119DMPK0.54269821
120JAK20.54029092
121ROCK20.53780126
122MAPK100.53775759
123RAF10.53741881
124IKBKB0.53705525
125PAK20.53610501
126CLK10.53526373
127GSK3A0.53281940
128CAMK1G0.52609278
129PTK20.51625602
130RPS6KC10.49517368
131RPS6KL10.49517368
132UHMK10.48537144
133FGFR30.48496866
134MAP3K10.48445168
135CDC42BPA0.47114238
136RPS6KA30.47002999
137DYRK20.46468227
138MAP3K100.45441152
139NTRK20.45359655
140PIK3CG0.45002155
141MAP3K30.43062553
142PRKAA10.42238209
143MELK0.41870865
144RET0.40967007
145PRKD10.40445726
146PTK2B0.40082381
147MAPK110.39927988
148CSNK1G10.39883585
149CAMK2B0.39628011
150PRKAA20.39605353
151ITK0.39209341
152OXSR10.37870794
153MAPKAPK20.35606404
154MARK30.34085373
155CSNK1G30.33947001
156TNK20.33520866
157ABL10.33166833
158PTK60.33018279

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.43772204
2Protein export_Homo sapiens_hsa030603.83029441
3Sulfur metabolism_Homo sapiens_hsa009202.01308181
4Type I diabetes mellitus_Homo sapiens_hsa049401.98284157
5Graft-versus-host disease_Homo sapiens_hsa053321.80077540
6Long-term potentiation_Homo sapiens_hsa047201.71647155
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.67095077
8Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65519004
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58321263
10Leishmaniasis_Homo sapiens_hsa051401.54015884
11Amphetamine addiction_Homo sapiens_hsa050311.53203459
12Circadian entrainment_Homo sapiens_hsa047131.52484983
13Renin secretion_Homo sapiens_hsa049241.50005462
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47660054
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42536737
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39291051
17GnRH signaling pathway_Homo sapiens_hsa049121.37945016
18Rheumatoid arthritis_Homo sapiens_hsa053231.36674256
19Gastric acid secretion_Homo sapiens_hsa049711.34356416
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32953435
21Glutamatergic synapse_Homo sapiens_hsa047241.32630125
22Nicotine addiction_Homo sapiens_hsa050331.31235582
23mTOR signaling pathway_Homo sapiens_hsa041501.30824872
24Phospholipase D signaling pathway_Homo sapiens_hsa040721.30475831
25Type II diabetes mellitus_Homo sapiens_hsa049301.28879065
26Estrogen signaling pathway_Homo sapiens_hsa049151.28739637
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28443499
28Insulin secretion_Homo sapiens_hsa049111.28421328
29Sphingolipid metabolism_Homo sapiens_hsa006001.27704299
30Oxytocin signaling pathway_Homo sapiens_hsa049211.24850874
31Steroid biosynthesis_Homo sapiens_hsa001001.23980859
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23319217
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22945289
34Dopaminergic synapse_Homo sapiens_hsa047281.22655459
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22435938
36Other glycan degradation_Homo sapiens_hsa005111.22001661
37Synaptic vesicle cycle_Homo sapiens_hsa047211.21784125
38TNF signaling pathway_Homo sapiens_hsa046681.21650623
39Morphine addiction_Homo sapiens_hsa050321.18349646
40Glioma_Homo sapiens_hsa052141.17529074
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16761342
42Osteoclast differentiation_Homo sapiens_hsa043801.16754259
43Circadian rhythm_Homo sapiens_hsa047101.16143552
44Long-term depression_Homo sapiens_hsa047301.15596169
45Prolactin signaling pathway_Homo sapiens_hsa049171.15255503
46cAMP signaling pathway_Homo sapiens_hsa040241.14302362
47Legionellosis_Homo sapiens_hsa051341.13665098
48GABAergic synapse_Homo sapiens_hsa047271.13664889
49Tuberculosis_Homo sapiens_hsa051521.13279240
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13101235
51Ovarian steroidogenesis_Homo sapiens_hsa049131.11767907
52Vibrio cholerae infection_Homo sapiens_hsa051101.11462767
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10900998
54Malaria_Homo sapiens_hsa051441.10891636
55Pertussis_Homo sapiens_hsa051331.08830655
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08474123
57Melanogenesis_Homo sapiens_hsa049161.07104799
58Prostate cancer_Homo sapiens_hsa052151.06020820
59Phagosome_Homo sapiens_hsa041451.05318833
60Choline metabolism in cancer_Homo sapiens_hsa052311.05139944
61Dorso-ventral axis formation_Homo sapiens_hsa043201.03362324
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01913118
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01222143
64VEGF signaling pathway_Homo sapiens_hsa043701.00663250
65Non-small cell lung cancer_Homo sapiens_hsa052230.99291207
66Amoebiasis_Homo sapiens_hsa051460.98888365
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98155938
68Bile secretion_Homo sapiens_hsa049760.97843001
69Chemokine signaling pathway_Homo sapiens_hsa040620.97792309
70Lysosome_Homo sapiens_hsa041420.97464761
71Salivary secretion_Homo sapiens_hsa049700.96704925
72Inositol phosphate metabolism_Homo sapiens_hsa005620.95176603
73Cocaine addiction_Homo sapiens_hsa050300.94994299
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.92435290
75AMPK signaling pathway_Homo sapiens_hsa041520.91440568
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90894384
77MAPK signaling pathway_Homo sapiens_hsa040100.90608030
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89789592
79Gap junction_Homo sapiens_hsa045400.89693110
80Allograft rejection_Homo sapiens_hsa053300.89105579
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88999903
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88402379
83Prion diseases_Homo sapiens_hsa050200.87719478
84Cholinergic synapse_Homo sapiens_hsa047250.87293699
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86187616
86Toxoplasmosis_Homo sapiens_hsa051450.84430432
87Measles_Homo sapiens_hsa051620.83182266
88Asthma_Homo sapiens_hsa053100.82562800
89Chronic myeloid leukemia_Homo sapiens_hsa052200.81643070
90Platelet activation_Homo sapiens_hsa046110.81483132
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80659007
92Endometrial cancer_Homo sapiens_hsa052130.80515621
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80307265
94Rap1 signaling pathway_Homo sapiens_hsa040150.80083541
95Calcium signaling pathway_Homo sapiens_hsa040200.80030744
96Hepatitis C_Homo sapiens_hsa051600.79534370
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.79175884
98Notch signaling pathway_Homo sapiens_hsa043300.78220187
99Salmonella infection_Homo sapiens_hsa051320.77316660
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.76882500
101Insulin resistance_Homo sapiens_hsa049310.76535707
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75076687
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73823505
104Thyroid hormone synthesis_Homo sapiens_hsa049180.72943748
105Colorectal cancer_Homo sapiens_hsa052100.72215511
106Ether lipid metabolism_Homo sapiens_hsa005650.71556423
107Serotonergic synapse_Homo sapiens_hsa047260.71284386
108Protein digestion and absorption_Homo sapiens_hsa049740.71254567
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71214142
110T cell receptor signaling pathway_Homo sapiens_hsa046600.71148909
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70840636
112Insulin signaling pathway_Homo sapiens_hsa049100.70191384
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.70108950
114Glucagon signaling pathway_Homo sapiens_hsa049220.69774018
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.68914343
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67591698
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67373927
118Adherens junction_Homo sapiens_hsa045200.67313382
119ECM-receptor interaction_Homo sapiens_hsa045120.66904570
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66694433
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65953893
122Hematopoietic cell lineage_Homo sapiens_hsa046400.65861709
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63952644
124N-Glycan biosynthesis_Homo sapiens_hsa005100.62222525
125ABC transporters_Homo sapiens_hsa020100.61811616
126FoxO signaling pathway_Homo sapiens_hsa040680.61680975
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.61218157
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.60500011
129Influenza A_Homo sapiens_hsa051640.60303954
130Axon guidance_Homo sapiens_hsa043600.59925518
131Renal cell carcinoma_Homo sapiens_hsa052110.59618248
132Pancreatic cancer_Homo sapiens_hsa052120.59379068
133Endocytosis_Homo sapiens_hsa041440.57605621
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55849178
135Focal adhesion_Homo sapiens_hsa045100.55170513
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54150493
137Apoptosis_Homo sapiens_hsa042100.51960364
138HIF-1 signaling pathway_Homo sapiens_hsa040660.51926629
139Hepatitis B_Homo sapiens_hsa051610.51658072
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51241811
141Acute myeloid leukemia_Homo sapiens_hsa052210.50817189
142Hedgehog signaling pathway_Homo sapiens_hsa043400.50804113
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50505332
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50498495
145African trypanosomiasis_Homo sapiens_hsa051430.50076103
146Pancreatic secretion_Homo sapiens_hsa049720.50075647
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.50002536
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49641508
149Olfactory transduction_Homo sapiens_hsa047400.49538256
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48895447
151Ras signaling pathway_Homo sapiens_hsa040140.47972993
152Autoimmune thyroid disease_Homo sapiens_hsa053200.47904794
153B cell receptor signaling pathway_Homo sapiens_hsa046620.47144315
154ErbB signaling pathway_Homo sapiens_hsa040120.46747126
155Dilated cardiomyopathy_Homo sapiens_hsa054140.46020805
156Wnt signaling pathway_Homo sapiens_hsa043100.45793841
157Viral myocarditis_Homo sapiens_hsa054160.45668871
158Proteoglycans in cancer_Homo sapiens_hsa052050.45350118
159TGF-beta signaling pathway_Homo sapiens_hsa043500.45189864
160Fatty acid elongation_Homo sapiens_hsa000620.44556087

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