TSHZ2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)5.94020087
2pyrimidine nucleobase catabolic process (GO:0006208)3.98772129
3sensory perception of chemical stimulus (GO:0007606)3.70960331
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.68586071
5behavioral response to nicotine (GO:0035095)3.58037499
6nucleobase catabolic process (GO:0046113)3.39552287
7drug catabolic process (GO:0042737)3.36462021
8kidney morphogenesis (GO:0060993)3.26083574
9activation of protein kinase A activity (GO:0034199)3.24522495
10exogenous drug catabolic process (GO:0042738)3.21959801
11neuron cell-cell adhesion (GO:0007158)3.21048457
12adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.13147956
13layer formation in cerebral cortex (GO:0021819)3.13002792
14cell migration in hindbrain (GO:0021535)3.01512272
15regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00128413
16neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.99878302
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99618244
18innervation (GO:0060384)2.97937358
19detection of calcium ion (GO:0005513)2.95782602
20negative regulation of sodium ion transport (GO:0010766)2.88859617
21peripheral nervous system neuron development (GO:0048935)2.87159973
22axonal fasciculation (GO:0007413)2.86699987
23glutamate secretion (GO:0014047)2.86225242
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85833964
25postsynaptic membrane organization (GO:0001941)2.84508287
26cAMP catabolic process (GO:0006198)2.84416872
27neuronal action potential (GO:0019228)2.77587743
28regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76175215
29regulation of synaptic vesicle exocytosis (GO:2000300)2.75336413
30tryptophan catabolic process (GO:0006569)2.75012553
31indole-containing compound catabolic process (GO:0042436)2.75012553
32indolalkylamine catabolic process (GO:0046218)2.75012553
33proline transport (GO:0015824)2.74071863
34gamma-aminobutyric acid transport (GO:0015812)2.73222057
35protein localization to cilium (GO:0061512)2.71184985
36regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.70774075
37cell communication involved in cardiac conduction (GO:0086065)2.70643129
38regulation of female gonad development (GO:2000194)2.67498785
39synaptic vesicle maturation (GO:0016188)2.66542066
40neuron recognition (GO:0008038)2.65937836
41membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.65837626
42membrane depolarization during action potential (GO:0086010)2.65509083
43calcium-mediated signaling using intracellular calcium source (GO:0035584)2.65444324
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.65271091
45relaxation of cardiac muscle (GO:0055119)2.63654590
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.63274597
47presynaptic membrane assembly (GO:0097105)2.61359160
48positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.61304607
49synaptic vesicle docking involved in exocytosis (GO:0016081)2.60925664
50presynaptic membrane organization (GO:0097090)2.59920864
51regulation of axon extension involved in axon guidance (GO:0048841)2.58877084
52synaptic vesicle exocytosis (GO:0016079)2.58520864
53axon extension (GO:0048675)2.57790714
54regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.57405454
55dopamine receptor signaling pathway (GO:0007212)2.57137042
56cyclic nucleotide catabolic process (GO:0009214)2.56597679
57neurofilament cytoskeleton organization (GO:0060052)2.55908724
58negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55841719
59negative regulation of translation, ncRNA-mediated (GO:0040033)2.55841719
60regulation of translation, ncRNA-mediated (GO:0045974)2.55841719
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.54323673
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.52908080
63oxidative demethylation (GO:0070989)2.50699667
64metanephric mesenchyme development (GO:0072075)2.50001672
65auditory behavior (GO:0031223)2.49590019
66dendrite morphogenesis (GO:0048813)2.48504604
67axon extension involved in axon guidance (GO:0048846)2.48346029
68neuron projection extension involved in neuron projection guidance (GO:1902284)2.48346029
69mating behavior (GO:0007617)2.47995810
70negative regulation of dendrite morphogenesis (GO:0050774)2.47272702
71benzene-containing compound metabolic process (GO:0042537)2.47141984
72central nervous system projection neuron axonogenesis (GO:0021952)2.44190249
73negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44032311
74transmission of nerve impulse (GO:0019226)2.43629379
75cell communication by electrical coupling (GO:0010644)2.41717958
76gonadal mesoderm development (GO:0007506)2.41604805
77somite development (GO:0061053)2.41567995
78limb development (GO:0060173)2.41226315
79appendage development (GO:0048736)2.41226315
80cellular ketone body metabolic process (GO:0046950)2.40173355
81indolalkylamine metabolic process (GO:0006586)2.39454314
82membrane repolarization during action potential (GO:0086011)2.39091375
83positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.38722318
84regulation of synaptic vesicle transport (GO:1902803)2.37571649
85cellular response to glucagon stimulus (GO:0071377)2.37304852
86regulation of heart rate by cardiac conduction (GO:0086091)2.37092698
87kidney mesenchyme development (GO:0072074)2.37009908
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.36940056
89potassium ion homeostasis (GO:0055075)2.36899332
90vocalization behavior (GO:0071625)2.36877007
91cellular response to prostaglandin stimulus (GO:0071379)2.35711690
92regulation of respiratory system process (GO:0044065)2.35703600
93regulation of axon guidance (GO:1902667)2.34889742
94synapse assembly (GO:0007416)2.34323665
95cilium or flagellum-dependent cell motility (GO:0001539)2.34138979
96urinary tract smooth muscle contraction (GO:0014848)2.34118709
97positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.34007783
98protein polyglutamylation (GO:0018095)2.32647380
99positive regulation of sodium ion transmembrane transport (GO:1902307)2.32050753
100cochlea development (GO:0090102)2.31708803
101tachykinin receptor signaling pathway (GO:0007217)2.30879282
102cellular potassium ion homeostasis (GO:0030007)2.30612155
103negative regulation of complement activation (GO:0045916)2.29601181
104membrane repolarization (GO:0086009)2.28240905
105protein insertion into membrane (GO:0051205)2.27674189
106positive regulation of synaptic transmission, GABAergic (GO:0032230)2.26790708
107regulation of cell communication by electrical coupling (GO:0010649)2.26592338
108regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.26585902
109cilium movement (GO:0003341)2.26157629
110smooth muscle contraction (GO:0006939)2.25638800
111establishment of protein localization to Golgi (GO:0072600)2.25360326
112regulation of sodium ion transmembrane transporter activity (GO:2000649)2.24944275
113central nervous system neuron axonogenesis (GO:0021955)2.24906373
114regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.24573440
115positive regulation of muscle hypertrophy (GO:0014742)2.24561187
116positive regulation of cardiac muscle hypertrophy (GO:0010613)2.24561187
117relaxation of muscle (GO:0090075)2.23591724
118peptidyl-tyrosine autophosphorylation (GO:0038083)2.23263419
119regulation of membrane repolarization (GO:0060306)2.23150854
120positive regulation of glycogen biosynthetic process (GO:0045725)2.22670943
121axoneme assembly (GO:0035082)2.22410411
122potassium ion export (GO:0071435)2.22401852
123regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.21689567
124glucocorticoid biosynthetic process (GO:0006704)2.21173163
125regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.20266760
126detection of temperature stimulus involved in sensory perception (GO:0050961)2.19937296
127detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.19937296
128tryptophan metabolic process (GO:0006568)2.18016067
129negative chemotaxis (GO:0050919)2.17905984
130suckling behavior (GO:0001967)2.17780864
131regulation of respiratory gaseous exchange (GO:0043576)2.17396043
132regulation of non-canonical Wnt signaling pathway (GO:2000050)2.16275826
133epithelial cilium movement (GO:0003351)2.16032706
134calcium ion-dependent exocytosis (GO:0017156)2.15676091
135detection of temperature stimulus (GO:0016048)2.15606206
136kynurenine metabolic process (GO:0070189)2.15258862
137gamma-aminobutyric acid signaling pathway (GO:0007214)2.14826193
138neuron projection extension (GO:1990138)2.14226819
139nephron tubule morphogenesis (GO:0072078)2.14120774
140nephron epithelium morphogenesis (GO:0072088)2.14120774
141regulation of cAMP-dependent protein kinase activity (GO:2000479)2.13978761
142axon ensheathment in central nervous system (GO:0032291)2.13767019
143central nervous system myelination (GO:0022010)2.13767019
144negative regulation of synaptic transmission, GABAergic (GO:0032229)2.13759299
145nucleus localization (GO:0051647)2.13173596
146regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.11911957
147cerebellar Purkinje cell differentiation (GO:0021702)2.11795676
148peristalsis (GO:0030432)2.11675076
149bundle of His cell to Purkinje myocyte communication (GO:0086069)2.11539527
150regulation of synapse structural plasticity (GO:0051823)2.11458083
151positive regulation of axon extension (GO:0045773)2.11205602
152retinal ganglion cell axon guidance (GO:0031290)2.11147549
153dendritic spine morphogenesis (GO:0060997)2.11063425
154cardiac conduction (GO:0061337)2.10860773
155metanephric tubule development (GO:0072170)2.10797207
156metanephric nephron tubule development (GO:0072234)2.10797207
157establishment of nucleus localization (GO:0040023)2.10564182
158androgen biosynthetic process (GO:0006702)2.10546886
159positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.09604987
160neuron maturation (GO:0042551)2.09555667
161protein localization to synapse (GO:0035418)2.08927140
162phosphorelay signal transduction system (GO:0000160)2.08916472
163positive regulation of fatty acid oxidation (GO:0046321)2.08865059
164head development (GO:0060322)2.08123386
165positive regulation of glycolytic process (GO:0045821)2.07772861
166enteric nervous system development (GO:0048484)2.07087462
167detection of light stimulus involved in visual perception (GO:0050908)2.06470256
168detection of light stimulus involved in sensory perception (GO:0050962)2.06470256
169negative regulation of catenin import into nucleus (GO:0035414)2.06098890
170growth hormone secretion (GO:0030252)2.06012252
171toxin metabolic process (GO:0009404)2.06005131
172positive regulation of potassium ion transmembrane transport (GO:1901381)2.05956360
173positive regulation of synapse assembly (GO:0051965)2.05922635
174plasma membrane repair (GO:0001778)2.05636036
175intraciliary transport (GO:0042073)2.04612365
176action potential (GO:0001508)2.04592686
177interkinetic nuclear migration (GO:0022027)2.04263984
178sympathetic nervous system development (GO:0048485)2.03521475
179alkaloid metabolic process (GO:0009820)2.03372634
180lymphangiogenesis (GO:0001946)2.03336857
181ketone body metabolic process (GO:1902224)2.03116612
182neuronal action potential propagation (GO:0019227)2.03056724
183mechanosensory behavior (GO:0007638)2.02748728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.92606155
2EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73183660
3RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73183660
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60677458
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59373014
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57577974
7GBX2_23144817_ChIP-Seq_PC3_Human2.51302988
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.49511225
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47563511
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.45623501
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37230285
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36582136
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33146839
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17661766
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13988564
16TAF15_26573619_Chip-Seq_HEK293_Human2.02529805
17VDR_22108803_ChIP-Seq_LS180_Human2.01673289
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.01624981
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.99623422
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97920795
21* DROSHA_22980978_ChIP-Seq_HELA_Human1.75142885
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74840835
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74819418
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71192562
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67040291
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62078196
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58287212
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58244555
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55186146
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54988784
31REST_21632747_ChIP-Seq_MESCs_Mouse1.52261674
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51680556
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.48793522
34NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45853573
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45162276
36SMAD4_21799915_ChIP-Seq_A2780_Human1.44705645
37* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42801869
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.42655599
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.42367254
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.41881367
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39490685
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.37482034
43* AHR_22903824_ChIP-Seq_MCF-7_Human1.37110024
44* TCF4_23295773_ChIP-Seq_U87_Human1.32700942
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32594210
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32495601
47* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29508312
48FUS_26573619_Chip-Seq_HEK293_Human1.28726805
49* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28389123
50RNF2_27304074_Chip-Seq_NSC_Mouse1.27744820
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27318612
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.27244767
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26089723
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25820576
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.25337321
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25248507
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24743401
58* RING1B_27294783_Chip-Seq_NPCs_Mouse1.24675089
59* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24651250
60* ARNT_22903824_ChIP-Seq_MCF-7_Human1.23677980
61AR_21572438_ChIP-Seq_LNCaP_Human1.23547700
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22936727
63KDM2B_26808549_Chip-Seq_K562_Human1.21472711
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.21152093
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.20875261
66* ER_23166858_ChIP-Seq_MCF-7_Human1.20783197
67* P300_19829295_ChIP-Seq_ESCs_Human1.20204231
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.16771644
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15505191
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13589227
71* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12911992
72* TCF4_22108803_ChIP-Seq_LS180_Human1.12832482
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11425853
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10981635
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.10631828
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10238670
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09967721
78SMAD4_21741376_ChIP-Seq_HESCs_Human1.09399237
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.09202041
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08392261
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08237497
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.08162763
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.08154645
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.07592404
85* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07405555
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06327242
87EWS_26573619_Chip-Seq_HEK293_Human1.06225664
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06087584
89RARB_27405468_Chip-Seq_BRAIN_Mouse1.05906095
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05447215
91CBP_20019798_ChIP-Seq_JUKART_Human1.05447215
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05370991
93BCAT_22108803_ChIP-Seq_LS180_Human1.03688832
94TP53_16413492_ChIP-PET_HCT116_Human1.02806317
95* KDM2B_26808549_Chip-Seq_REH_Human1.00971909
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00964740
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00689474
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00689474
99* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00279368
100RXR_22108803_ChIP-Seq_LS180_Human1.00275295
101* AR_19668381_ChIP-Seq_PC3_Human1.00035831
102YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99760987
103* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99725443
104NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99252039
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99183921
106* NANOG_18555785_Chip-Seq_ESCs_Mouse0.99118971
107SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99097937
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98622044
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98363982
110* STAT3_23295773_ChIP-Seq_U87_Human0.97543348
111* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97513352
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97364259
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97329433
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95856754
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95219231
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.95020173
117TP53_18474530_ChIP-ChIP_U2OS_Human0.94558726
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.94546860
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.94274160
120* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93377408
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93185694
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92585907
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90049030
124ZNF274_21170338_ChIP-Seq_K562_Hela0.88799691
125IGF1R_20145208_ChIP-Seq_DFB_Human0.88793073
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.88571708
127RUNX2_22187159_ChIP-Seq_PCA_Human0.87773134
128AR_25329375_ChIP-Seq_VCAP_Human0.87562081
129* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87481273
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84671469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.28479159
2MP0004270_analgesia3.00063460
3MP0002735_abnormal_chemical_nociception2.56009168
4MP0001968_abnormal_touch/_nociception2.55458312
5MP0006276_abnormal_autonomic_nervous2.54254772
6MP0002734_abnormal_mechanical_nocicepti2.51842695
7MP0004858_abnormal_nervous_system2.38861244
8MP0008789_abnormal_olfactory_epithelium2.35176640
9MP0005645_abnormal_hypothalamus_physiol2.34492220
10MP0005394_taste/olfaction_phenotype2.29366206
11MP0005499_abnormal_olfactory_system2.29366206
12MP0002184_abnormal_innervation2.18603108
13MP0004859_abnormal_synaptic_plasticity2.17377879
14MP0000566_synostosis2.16000482
15MP0003122_maternal_imprinting2.15477566
16MP0005670_abnormal_white_adipose2.15474123
17MP0003880_abnormal_central_pattern2.03886937
18MP0002822_catalepsy2.01702862
19MP0003195_calcinosis2.01539999
20MP0002736_abnormal_nociception_after1.91518023
21MP0002909_abnormal_adrenal_gland1.89492606
22MP0009780_abnormal_chondrocyte_physiolo1.89185885
23MP0002876_abnormal_thyroid_physiology1.88317647
24MP0000534_abnormal_ureter_morphology1.84520372
25MP0003635_abnormal_synaptic_transmissio1.84364549
26MP0002733_abnormal_thermal_nociception1.83640141
27MP0001970_abnormal_pain_threshold1.78746922
28MP0002837_dystrophic_cardiac_calcinosis1.76197380
29MP0003646_muscle_fatigue1.66568338
30MP0002638_abnormal_pupillary_reflex1.64676878
31MP0008875_abnormal_xenobiotic_pharmacok1.64428188
32MP0000778_abnormal_nervous_system1.62757677
33MP0000569_abnormal_digit_pigmentation1.59843967
34MP0003942_abnormal_urinary_system1.59216763
35MP0005551_abnormal_eye_electrophysiolog1.59112021
36MP0004130_abnormal_muscle_cell1.57243624
37MP0002272_abnormal_nervous_system1.54005111
38MP0001270_distended_abdomen1.47707226
39MP0000751_myopathy1.46682625
40MP0010329_abnormal_lipoprotein_level1.46248174
41MP0010386_abnormal_urinary_bladder1.45438204
42MP0005423_abnormal_somatic_nervous1.43550470
43MP0003011_delayed_dark_adaptation1.41993539
44MP0002102_abnormal_ear_morphology1.41061643
45MP0003787_abnormal_imprinting1.40648830
46MP0005623_abnormal_meninges_morphology1.36648942
47MP0004272_abnormal_basement_membrane1.36167064
48MP0002063_abnormal_learning/memory/cond1.34634848
49MP0000013_abnormal_adipose_tissue1.32707530
50MP0004142_abnormal_muscle_tone1.31537779
51MP0005085_abnormal_gallbladder_physiolo1.31405001
52MP0001188_hyperpigmentation1.30234930
53MP0000538_abnormal_urinary_bladder1.26445545
54MP0002557_abnormal_social/conspecific_i1.25607820
55MP0002751_abnormal_autonomic_nervous1.22286885
56MP0005503_abnormal_tendon_morphology1.20984222
57MP0009250_abnormal_appendicular_skeleto1.20616846
58MP0002067_abnormal_sensory_capabilities1.20615902
59MP0008004_abnormal_stomach_pH1.19530105
60MP0005386_behavior/neurological_phenoty1.18618413
61MP0004924_abnormal_behavior1.18618413
62MP0000955_abnormal_spinal_cord1.17360404
63MP0001486_abnormal_startle_reflex1.16159046
64MP0002882_abnormal_neuron_morphology1.14740954
65MP0005448_abnormal_energy_balance1.14077091
66MP0001299_abnormal_eye_distance/1.12413817
67MP0008872_abnormal_physiological_respon1.11851138
68MP0009745_abnormal_behavioral_response1.11789991
69MP0005365_abnormal_bile_salt1.11387530
70MP0002572_abnormal_emotion/affect_behav1.11322126
71MP0000372_irregular_coat_pigmentation1.11020726
72MP0004145_abnormal_muscle_electrophysio1.10506875
73MP0002896_abnormal_bone_mineralization1.07215549
74MP0000003_abnormal_adipose_tissue1.07048791
75MP0001501_abnormal_sleep_pattern1.05796907
76MP0002064_seizures1.04092633
77MP0005646_abnormal_pituitary_gland1.03698235
78MP0000230_abnormal_systemic_arterial1.02442170
79MP0002233_abnormal_nose_morphology1.02367939
80MP0002653_abnormal_ependyma_morphology1.01890293
81MP0004811_abnormal_neuron_physiology1.01076284
82MP0002752_abnormal_somatic_nervous1.01054462
83MP0003878_abnormal_ear_physiology1.00137346
84MP0005377_hearing/vestibular/ear_phenot1.00137346
85MP0002138_abnormal_hepatobiliary_system0.99126463
86MP0002160_abnormal_reproductive_system0.98601329
87MP0000516_abnormal_urinary_system0.98267662
88MP0005367_renal/urinary_system_phenotyp0.98267662
89MP0000026_abnormal_inner_ear0.97895810
90MP0002295_abnormal_pulmonary_circulatio0.97165508
91MP0010368_abnormal_lymphatic_system0.96078073
92MP0008961_abnormal_basal_metabolism0.94441646
93MP0000427_abnormal_hair_cycle0.92950276
94MP0003045_fibrosis0.92639743
95MP0004043_abnormal_pH_regulation0.91408840
96MP0005253_abnormal_eye_physiology0.90145002
97MP0009046_muscle_twitch0.90077587
98MP0003385_abnormal_body_wall0.90004617
99MP0005084_abnormal_gallbladder_morpholo0.89981546
100MP0002249_abnormal_larynx_morphology0.89752617
101MP0005379_endocrine/exocrine_gland_phen0.89410990
102MP0002938_white_spotting0.89224903
103MP0002282_abnormal_trachea_morphology0.88095674
104MP0005187_abnormal_penis_morphology0.86886050
105MP0005167_abnormal_blood-brain_barrier0.85388347
106MP0003938_abnormal_ear_development0.85365026
107MP0005595_abnormal_vascular_smooth0.85315664
108MP0000639_abnormal_adrenal_gland0.84944387
109MP0000049_abnormal_middle_ear0.84773360
110MP0004085_abnormal_heartbeat0.83999706
111MP0002168_other_aberrant_phenotype0.83917987
112MP0002928_abnormal_bile_duct0.83653902
113MP0004133_heterotaxia0.82756289
114MP0001502_abnormal_circadian_rhythm0.82241602
115MP0001485_abnormal_pinna_reflex0.82108697
116MP0003121_genomic_imprinting0.81970766
117MP0008877_abnormal_DNA_methylation0.80598533
118MP0000537_abnormal_urethra_morphology0.78843737
119MP0002877_abnormal_melanocyte_morpholog0.78182845
120MP0003283_abnormal_digestive_organ0.78166684
121MP0005195_abnormal_posterior_eye0.76780915
122MP0001944_abnormal_pancreas_morphology0.76322158
123MP0003937_abnormal_limbs/digits/tail_de0.76009554
124MP0001963_abnormal_hearing_physiology0.75677656
125MP0004215_abnormal_myocardial_fiber0.74812043
126MP0001440_abnormal_grooming_behavior0.74611123
127MP0004484_altered_response_of0.74552948
128MP0001879_abnormal_lymphatic_vessel0.74324638
129MP0002152_abnormal_brain_morphology0.72782329
130MP0003879_abnormal_hair_cell0.72470575
131MP0004885_abnormal_endolymph0.72219677
132MP0008438_abnormal_cutaneous_collagen0.72156957
133MP0001986_abnormal_taste_sensitivity0.70941034
134MP0000613_abnormal_salivary_gland0.70582819
135MP0000631_abnormal_neuroendocrine_gland0.70482711
136MP0005275_abnormal_skin_tensile0.70207231
137MP0002108_abnormal_muscle_morphology0.69945224
138MP0000163_abnormal_cartilage_morphology0.68054050
139MP0003634_abnormal_glial_cell0.66587423
140MP0008569_lethality_at_weaning0.66495519
141MP0002163_abnormal_gland_morphology0.66044628
142MP0001664_abnormal_digestion0.65822267
143MP0004134_abnormal_chest_morphology0.65088936
144MP0002066_abnormal_motor_capabilities/c0.63899037

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.56378442
2Myokymia (HP:0002411)3.44378672
3Genetic anticipation (HP:0003743)3.39308676
4Pancreatic cysts (HP:0001737)3.36697505
5Decreased circulating renin level (HP:0003351)3.27165604
6True hermaphroditism (HP:0010459)3.19621290
7Type II lissencephaly (HP:0007260)3.16235012
8Pancreatic fibrosis (HP:0100732)3.15180853
9Nephronophthisis (HP:0000090)3.10274054
10Abnormality of the renal medulla (HP:0100957)3.00918275
11Potter facies (HP:0002009)3.00469895
12Facial shape deformation (HP:0011334)3.00469895
13Broad-based gait (HP:0002136)2.95687026
14Retinal dysplasia (HP:0007973)2.85893832
15Ulnar claw (HP:0001178)2.79558647
16Hepatoblastoma (HP:0002884)2.78307889
17Agitation (HP:0000713)2.77761514
18Limb dystonia (HP:0002451)2.76074961
19Anosmia (HP:0000458)2.75988090
20Bifid tongue (HP:0010297)2.73208575
21Gaze-evoked nystagmus (HP:0000640)2.69724993
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.69449686
23Cystic liver disease (HP:0006706)2.67985023
24Abnormality of the renal cortex (HP:0011035)2.66575340
25Action tremor (HP:0002345)2.65457600
26Atonic seizures (HP:0010819)2.59063584
27Hypoventilation (HP:0002791)2.58344080
28Thoracolumbar scoliosis (HP:0002944)2.57672680
29Impaired pain sensation (HP:0007328)2.55384924
30Abnormality of pain sensation (HP:0010832)2.55384924
31Oligodactyly (hands) (HP:0001180)2.53219989
32Focal seizures (HP:0007359)2.52899066
33Increased corneal curvature (HP:0100692)2.52709431
34Keratoconus (HP:0000563)2.52709431
35Hypothermia (HP:0002045)2.49799407
36Testicular neoplasm (HP:0010788)2.48014367
37Fair hair (HP:0002286)2.43556409
38Medial flaring of the eyebrow (HP:0010747)2.42037689
39Chronic hepatic failure (HP:0100626)2.41970785
40Torticollis (HP:0000473)2.35848811
41Abnormality of macular pigmentation (HP:0008002)2.34812978
42Prolonged QT interval (HP:0001657)2.34301331
43Myotonia (HP:0002486)2.30657343
44Pheochromocytoma (HP:0002666)2.30140428
45Sleep apnea (HP:0010535)2.29075662
46Cutaneous finger syndactyly (HP:0010554)2.27509681
47Hypoplastic nipples (HP:0002557)2.23836836
48Absent speech (HP:0001344)2.23299763
49Drooling (HP:0002307)2.22301823
50Complement deficiency (HP:0004431)2.21614412
51Abnormality of calcium-phosphate metabolism (HP:0100530)2.21285908
52Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.20831096
53Buphthalmos (HP:0000557)2.20140261
54Labial hypoplasia (HP:0000066)2.19785993
55Amblyopia (HP:0000646)2.18678392
56Polyphagia (HP:0002591)2.17892973
57Decreased central vision (HP:0007663)2.16950799
58Tubular atrophy (HP:0000092)2.16158187
59Overgrowth (HP:0001548)2.16110063
60Febrile seizures (HP:0002373)2.15737228
61Absent eyebrow (HP:0002223)2.13831211
62Lissencephaly (HP:0001339)2.13245861
63Syncope (HP:0001279)2.12936657
64Bronchomalacia (HP:0002780)2.11265275
65Protruding tongue (HP:0010808)2.10535887
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10312773
67Enlarged penis (HP:0000040)2.09874412
68Congenital glaucoma (HP:0001087)2.08711181
69Genital tract atresia (HP:0001827)2.07499160
70Hypoplastic ischia (HP:0003175)2.06108370
71Aplasia/Hypoplasia of the tibia (HP:0005772)2.05915625
72Bradycardia (HP:0001662)2.05793003
73Visual hallucinations (HP:0002367)2.04617658
74Oligomenorrhea (HP:0000876)2.04237183
75Widely spaced teeth (HP:0000687)2.03127545
76Vaginal atresia (HP:0000148)2.01807968
77Broad metatarsal (HP:0001783)2.01087180
78Asymmetry of the thorax (HP:0001555)2.00510379
79Termporal pattern (HP:0011008)2.00231091
80Insidious onset (HP:0003587)2.00231091
81Ankle clonus (HP:0011448)1.99433035
82Pachygyria (HP:0001302)1.99379003
83Germ cell neoplasia (HP:0100728)1.98527280
84Failure to thrive in infancy (HP:0001531)1.98001465
85Cutaneous syndactyly (HP:0012725)1.97891947
86Limited hip movement (HP:0008800)1.97816556
87Excessive salivation (HP:0003781)1.97749810
88Abnormal respiratory motile cilium physiology (HP:0012261)1.96461157
89Congenital primary aphakia (HP:0007707)1.95371958
90Inability to walk (HP:0002540)1.94773552
91Ventricular fibrillation (HP:0001663)1.94498773
92Cerebellar dysplasia (HP:0007033)1.94322900
93Striae distensae (HP:0001065)1.93891317
94Craniofacial dystonia (HP:0012179)1.92487612
95Abnormality of dentin (HP:0010299)1.91048773
96Hyperaldosteronism (HP:0000859)1.90936576
97Focal motor seizures (HP:0011153)1.90638151
98Bicornuate uterus (HP:0000813)1.90553535
99Abnormal pancreas size (HP:0012094)1.90523196
100Large for gestational age (HP:0001520)1.89923067
101Neuroendocrine neoplasm (HP:0100634)1.89527814
102Short foot (HP:0001773)1.89247732
103Focal dystonia (HP:0004373)1.88943455
104Thyroid carcinoma (HP:0002890)1.88538178
105Arthropathy (HP:0003040)1.88447152
106Male pseudohermaphroditism (HP:0000037)1.87964514
107Polydipsia (HP:0001959)1.87431769
108Abnormal drinking behavior (HP:0030082)1.87431769
109Supranuclear gaze palsy (HP:0000605)1.87415065
110Hypercortisolism (HP:0001578)1.87013866
111Epileptic encephalopathy (HP:0200134)1.86427356
112Generalized hypopigmentation of hair (HP:0011358)1.86247352
113Aortic aneurysm (HP:0004942)1.85983530
114Dynein arm defect of respiratory motile cilia (HP:0012255)1.85659736
115Absent/shortened dynein arms (HP:0200106)1.85659736
116Palpitations (HP:0001962)1.85479699
117Aplasia involving bones of the upper limbs (HP:0009823)1.84882585
118Aplasia of the phalanges of the hand (HP:0009802)1.84882585
119Aplasia involving bones of the extremities (HP:0009825)1.84882585
120Diastasis recti (HP:0001540)1.84793965
121Generalized tonic-clonic seizures (HP:0002069)1.84685229
122Morphological abnormality of the middle ear (HP:0008609)1.83203124
123Congenital stationary night blindness (HP:0007642)1.82798664
124Renal hypoplasia (HP:0000089)1.82524342
125Hyperthyroidism (HP:0000836)1.80957664
126Attenuation of retinal blood vessels (HP:0007843)1.80840044
127Rectal prolapse (HP:0002035)1.80349294
128Abnormal respiratory epithelium morphology (HP:0012253)1.80230205
129Abnormal respiratory motile cilium morphology (HP:0005938)1.80230205
130Absence seizures (HP:0002121)1.79998429
131Abnormality of renin-angiotensin system (HP:0000847)1.79822114
132Sex reversal (HP:0012245)1.79607210
133Abnormal sex determination (HP:0012244)1.79607210
134Abnormality of the pubic bones (HP:0003172)1.78848493
135Abnormal ciliary motility (HP:0012262)1.78783257
136Bulbous nose (HP:0000414)1.78291244
137Sudden death (HP:0001699)1.78086634
138Exotropia (HP:0000577)1.77887721
139Narrow nasal bridge (HP:0000446)1.77674999
140Short 4th metacarpal (HP:0010044)1.76394794
141Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76394794
142Abnormality of the renal collecting system (HP:0004742)1.76117539
143Blue irides (HP:0000635)1.75843048
144Anterior segment dysgenesis (HP:0007700)1.75422720
145Hypoplastic female external genitalia (HP:0012815)1.74453000
146Duplicated collecting system (HP:0000081)1.73211263
147Neoplasm of the heart (HP:0100544)1.73112511
148Poor coordination (HP:0002370)1.71136867
149Anophthalmia (HP:0000528)1.70700588
150Increased variability in muscle fiber diameter (HP:0003557)1.70614055
151Nephrogenic diabetes insipidus (HP:0009806)1.70559029
152Progressive cerebellar ataxia (HP:0002073)1.70475175
153Wrist flexion contracture (HP:0001239)1.70057747
154Epidermoid cyst (HP:0200040)1.69441669
155Shawl scrotum (HP:0000049)1.68941539
156Hypoplastic labia majora (HP:0000059)1.68814967
157Vertebral arch anomaly (HP:0008438)1.67999034
158Postaxial hand polydactyly (HP:0001162)1.67279883
159Infantile muscular hypotonia (HP:0008947)1.67029683
160Abnormality of midbrain morphology (HP:0002418)1.66982393
161Molar tooth sign on MRI (HP:0002419)1.66982393
162Omphalocele (HP:0001539)1.66448548
163Renal duplication (HP:0000075)1.66047518
164Congenital hepatic fibrosis (HP:0002612)1.65865532
165Megalencephaly (HP:0001355)1.65246373
166Oligodontia (HP:0000677)1.65057789
167Partial agenesis of the corpus callosum (HP:0001338)1.64125594
168Insomnia (HP:0100785)1.62954772
169Macroorchidism (HP:0000053)1.62588658
170Gait imbalance (HP:0002141)1.62391556
171Midline defect of the nose (HP:0004122)1.62241736
172Papillary thyroid carcinoma (HP:0002895)1.61291790
173Broad ribs (HP:0000885)1.59462223
174Depression (HP:0000716)1.56964136
175Lymphangioma (HP:0100764)1.56825745
176Abnormal EKG (HP:0003115)1.55988278
177Menstrual irregularities (HP:0000858)1.55444810
178Papilledema (HP:0001085)1.53716808
179Abnormality of the ischium (HP:0003174)1.53151609
180Enlarged kidneys (HP:0000105)1.51438048
181Dialeptic seizures (HP:0011146)1.48826836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK12.66211103
2PHKG22.62892493
3PHKG12.62892493
4PRKD32.26482150
5NTRK32.25191769
6BMPR1B2.23502152
7MAP3K22.08011088
8MARK12.06896728
9LATS21.99178547
10FRK1.98778050
11MINK11.89663034
12MAP3K91.89053427
13MAPK131.88859167
14DAPK21.80217803
15PINK11.80213022
16RIPK11.80112889
17FER1.78228685
18MAPK151.78223204
19MAPKAPK31.77815250
20INSRR1.76611139
21LMTK21.69089309
22MAP3K41.67327231
23CAMK1G1.66039630
24PAK31.64081371
25EPHB21.63531312
26GRK11.54195528
27TAOK31.52206668
28ADRBK21.52054286
29GRK51.50569226
30NLK1.47172935
31KSR21.46732471
32MAP2K71.43316767
33WNK41.35431827
34RET1.34556685
35CASK1.31033956
36ARAF1.26912552
37LATS11.26180297
38ACVR1B1.25008179
39PIK3CA1.22053015
40PAK61.20432857
41SGK2231.20392738
42SGK4941.20392738
43MAP3K71.19392811
44MAP4K21.17626556
45ADRBK11.15697266
46TRIB31.15450888
47PDGFRA1.14280441
48RPS6KA21.14033413
49ERBB31.13037148
50MAP2K41.11655023
51CAMK2D1.08984910
52TGFBR11.08160774
53CSNK1A1L1.07733641
54WNK11.06936424
55CAMK1D1.01207124
56FGFR20.98365265
57SGK20.97260091
58AKT30.95889567
59TIE10.94509150
60STK380.94384524
61MYLK0.94306752
62STK390.91678714
63CSNK1G20.91070627
64CAMK2B0.91059389
65OXSR10.90815562
66HIPK20.90648735
67MAP2K10.86463083
68TLK10.86272077
69LIMK10.86001415
70PRKAA20.85109762
71MAP2K20.84612710
72CDK50.84425535
73DDR20.83426501
74EPHA40.80772837
75CAMK2G0.77812772
76WNK30.77525489
77NTRK20.76269461
78MAP3K60.75690636
79CDC42BPA0.74468294
80PKN10.72555378
81CAMKK10.72147873
82PRKCH0.71848178
83PRKCE0.71521109
84CAMK2A0.71381149
85ERBB20.71129679
86NUAK10.70961035
87ROCK10.69743926
88SIK20.69169886
89PNCK0.69064040
90MAP3K10.68772917
91PRKCG0.68656457
92MARK20.68329665
93UHMK10.67438683
94SGK30.65880719
95STK38L0.65398041
96EEF2K0.65292758
97CSNK1G30.64887101
98EPHA30.63237577
99CSNK1G10.62920876
100PTK20.62464783
101PDGFRB0.61142311
102MAPKAPK50.60285335
103CAMKK20.59725661
104CAMK10.59137416
105BCR0.58849546
106OBSCN0.58828259
107DYRK1A0.58225948
108FGFR30.57289902
109SGK10.56773546
110ZAK0.56289306
111KSR10.54131889
112PRKG10.53935968
113PRKACA0.53790215
114TYRO30.53714116
115PRKCZ0.53470108
116PLK20.52817957
117PRKD10.52602986
118PTK2B0.50971738
119PRKD20.47666409
120CAMK40.47408827
121DYRK20.46386518
122TNIK0.45918725
123MAP3K120.43163511
124TRPM70.43103640
125MKNK20.42629971
126MAP2K60.42007864
127STK110.40433788
128CHUK0.40395483
129CSNK1A10.40317959
130SIK30.40199857
131SIK10.39705808
132MAPK120.39701134
133PRKAA10.38614435
134MAPK80.38517024
135RPS6KA30.38134584
136TNK20.38040568

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.23528070
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.64963762
3Insulin secretion_Homo sapiens_hsa049112.34344990
4Caffeine metabolism_Homo sapiens_hsa002322.31236117
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99150695
6Linoleic acid metabolism_Homo sapiens_hsa005911.92406332
7Butanoate metabolism_Homo sapiens_hsa006501.90726279
8Circadian entrainment_Homo sapiens_hsa047131.85673693
9Steroid hormone biosynthesis_Homo sapiens_hsa001401.84387316
10Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83712145
11Synaptic vesicle cycle_Homo sapiens_hsa047211.79959754
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79812044
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.74572109
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73185275
15Retinol metabolism_Homo sapiens_hsa008301.72201172
16Chemical carcinogenesis_Homo sapiens_hsa052041.68178016
17ABC transporters_Homo sapiens_hsa020101.62786748
18Taste transduction_Homo sapiens_hsa047421.60259907
19Dopaminergic synapse_Homo sapiens_hsa047281.59110730
20Gastric acid secretion_Homo sapiens_hsa049711.57159755
21GABAergic synapse_Homo sapiens_hsa047271.55547460
22Glutamatergic synapse_Homo sapiens_hsa047241.54775298
23Salivary secretion_Homo sapiens_hsa049701.53545443
24Cholinergic synapse_Homo sapiens_hsa047251.52378636
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51563092
26Morphine addiction_Homo sapiens_hsa050321.51075668
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47449584
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46355977
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44263855
30Tryptophan metabolism_Homo sapiens_hsa003801.41155739
31Renin secretion_Homo sapiens_hsa049241.40986378
32Histidine metabolism_Homo sapiens_hsa003401.40702770
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39709238
34Amphetamine addiction_Homo sapiens_hsa050311.37800622
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37621515
36Long-term potentiation_Homo sapiens_hsa047201.36568620
37Complement and coagulation cascades_Homo sapiens_hsa046101.34693026
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34649232
39Ovarian steroidogenesis_Homo sapiens_hsa049131.31746736
40Nicotine addiction_Homo sapiens_hsa050331.31572627
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29089333
42GnRH signaling pathway_Homo sapiens_hsa049121.27168956
43Melanogenesis_Homo sapiens_hsa049161.26081312
44Axon guidance_Homo sapiens_hsa043601.25420304
45Estrogen signaling pathway_Homo sapiens_hsa049151.24168745
46Gap junction_Homo sapiens_hsa045401.22890322
47cAMP signaling pathway_Homo sapiens_hsa040241.22683851
48Thyroid hormone synthesis_Homo sapiens_hsa049181.21168070
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19450410
50Pancreatic secretion_Homo sapiens_hsa049721.16285376
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15586808
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.15290997
53Glycerolipid metabolism_Homo sapiens_hsa005611.12271167
54Serotonergic synapse_Homo sapiens_hsa047261.12143957
55Phenylalanine metabolism_Homo sapiens_hsa003601.11580853
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11256631
57Dorso-ventral axis formation_Homo sapiens_hsa043201.08780144
58Oxytocin signaling pathway_Homo sapiens_hsa049211.07536550
59Cocaine addiction_Homo sapiens_hsa050301.06068398
60Phototransduction_Homo sapiens_hsa047441.05251940
61Calcium signaling pathway_Homo sapiens_hsa040201.04921315
62Protein digestion and absorption_Homo sapiens_hsa049741.01950631
63Dilated cardiomyopathy_Homo sapiens_hsa054140.99856158
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.99828893
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99333334
66Type II diabetes mellitus_Homo sapiens_hsa049300.99121894
67Bile secretion_Homo sapiens_hsa049760.98670635
68beta-Alanine metabolism_Homo sapiens_hsa004100.95557682
69Ether lipid metabolism_Homo sapiens_hsa005650.95225778
70Vibrio cholerae infection_Homo sapiens_hsa051100.94168221
71Glioma_Homo sapiens_hsa052140.94144142
72Tyrosine metabolism_Homo sapiens_hsa003500.92782209
73Arachidonic acid metabolism_Homo sapiens_hsa005900.91043826
74Glucagon signaling pathway_Homo sapiens_hsa049220.90798173
75PPAR signaling pathway_Homo sapiens_hsa033200.84797158
76Hedgehog signaling pathway_Homo sapiens_hsa043400.84251077
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83958549
78Long-term depression_Homo sapiens_hsa047300.83045464
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82587555
80Insulin signaling pathway_Homo sapiens_hsa049100.82377678
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78965211
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78466162
83Cardiac muscle contraction_Homo sapiens_hsa042600.77686689
84ECM-receptor interaction_Homo sapiens_hsa045120.77363043
85Endometrial cancer_Homo sapiens_hsa052130.76841424
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73457930
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.73409903
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73072987
89Fat digestion and absorption_Homo sapiens_hsa049750.71976748
90Arginine biosynthesis_Homo sapiens_hsa002200.71609116
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70210978
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69687800
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68078268
94Rap1 signaling pathway_Homo sapiens_hsa040150.67593567
95Lysine degradation_Homo sapiens_hsa003100.66647490
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66352754
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66123223
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.65521296
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65370985
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.64783797
101Peroxisome_Homo sapiens_hsa041460.63805097
102Ras signaling pathway_Homo sapiens_hsa040140.63530026
103ErbB signaling pathway_Homo sapiens_hsa040120.62536708
104Regulation of autophagy_Homo sapiens_hsa041400.60900277
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60713135
106Circadian rhythm_Homo sapiens_hsa047100.60195194
107Prion diseases_Homo sapiens_hsa050200.59233369
108Sulfur metabolism_Homo sapiens_hsa009200.58569710
109Melanoma_Homo sapiens_hsa052180.57809756
110Focal adhesion_Homo sapiens_hsa045100.57588167
111Wnt signaling pathway_Homo sapiens_hsa043100.56353284
112Nitrogen metabolism_Homo sapiens_hsa009100.56178961
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55661034
114Tight junction_Homo sapiens_hsa045300.54831176
115Amoebiasis_Homo sapiens_hsa051460.53084020
116Insulin resistance_Homo sapiens_hsa049310.52999224
117Fatty acid biosynthesis_Homo sapiens_hsa000610.50218043
118Collecting duct acid secretion_Homo sapiens_hsa049660.49163075
119Thyroid cancer_Homo sapiens_hsa052160.49097890
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48636625
121Prolactin signaling pathway_Homo sapiens_hsa049170.48522588
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48160231
123Hippo signaling pathway_Homo sapiens_hsa043900.47884756
124Propanoate metabolism_Homo sapiens_hsa006400.47104173
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46314517
126TGF-beta signaling pathway_Homo sapiens_hsa043500.46231824
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46039875
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45041895
129Basal cell carcinoma_Homo sapiens_hsa052170.44707243
130Prostate cancer_Homo sapiens_hsa052150.42862701
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42582120
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42268386
133Adherens junction_Homo sapiens_hsa045200.41096657
134AMPK signaling pathway_Homo sapiens_hsa041520.40866388
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40641868
136Choline metabolism in cancer_Homo sapiens_hsa052310.38780092
137Oocyte meiosis_Homo sapiens_hsa041140.38472926
138VEGF signaling pathway_Homo sapiens_hsa043700.37223682
139MAPK signaling pathway_Homo sapiens_hsa040100.36958305

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