ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.90410149
2	L-phenylalanine catabolic process (GO:0006559)	6.90410149
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.76853997
4	L-phenylalanine metabolic process (GO:0006558)	6.76853997
5	aromatic amino acid family catabolic process (GO:0009074)	6.33290342
6	indole-containing compound catabolic process (GO:0042436)	5.87801186
7	indolalkylamine catabolic process (GO:0046218)	5.87801186
8	tryptophan catabolic process (GO:0006569)	5.87801186
9	daunorubicin metabolic process (GO:0044597)	5.83945337
10	polyketide metabolic process (GO:0030638)	5.83945337
11	doxorubicin metabolic process (GO:0044598)	5.83945337
12	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.79533162
13	negative regulation of fibrinolysis (GO:0051918)	5.73749834
14	bile acid biosynthetic process (GO:0006699)	5.69784694
15	urea cycle (GO:0000050)	5.60582460
16	urea metabolic process (GO:0019627)	5.60582460
17	kynurenine metabolic process (GO:0070189)	5.60302769
18	regulation of fibrinolysis (GO:0051917)	5.45727876
19	tryptophan metabolic process (GO:0006568)	5.44710956
20	cellular glucuronidation (GO:0052695)	5.31030165
21	sulfur amino acid catabolic process (GO:0000098)	5.26798835
22	glyoxylate metabolic process (GO:0046487)	5.26540881
23	complement activation, alternative pathway (GO:0006957)	5.21440355
24	aminoglycoside antibiotic metabolic process (GO:0030647)	5.19441848
25	regulation of protein activation cascade (GO:2000257)	5.17102617
26	nitrogen cycle metabolic process (GO:0071941)	5.15304399
27	protein carboxylation (GO:0018214)	5.11021520
28	peptidyl-glutamic acid carboxylation (GO:0017187)	5.11021520
29	high-density lipoprotein particle remodeling (GO:0034375)	5.04043964
30	uronic acid metabolic process (GO:0006063)	5.01922524
31	glucuronate metabolic process (GO:0019585)	5.01922524
32	serine family amino acid catabolic process (GO:0009071)	4.99858307
33	alpha-linolenic acid metabolic process (GO:0036109)	4.93539685
34	regulation of complement activation (GO:0030449)	4.89361548
35	cysteine metabolic process (GO:0006534)	4.89012990
36	phenylpropanoid metabolic process (GO:0009698)	4.83933122
37	primary alcohol catabolic process (GO:0034310)	4.81138757
38	bile acid metabolic process (GO:0008206)	4.75215378
39	epoxygenase P450 pathway (GO:0019373)	4.72414930
40	regulation of cholesterol esterification (GO:0010872)	4.67527014
41	aromatic amino acid family metabolic process (GO:0009072)	4.62949220
42	regulation of triglyceride catabolic process (GO:0010896)	4.58614037
43	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.55614157
44	homocysteine metabolic process (GO:0050667)	4.49125067
45	reverse cholesterol transport (GO:0043691)	4.41544068
46	amino-acid betaine metabolic process (GO:0006577)	4.39213488
47	response to nitrosative stress (GO:0051409)	4.35092097
48	phospholipid efflux (GO:0033700)	4.31840644
49	glycine metabolic process (GO:0006544)	4.31087288
50	benzene-containing compound metabolic process (GO:0042537)	4.30224667
51	alpha-amino acid catabolic process (GO:1901606)	4.30128405
52	negative regulation of cholesterol transport (GO:0032375)	4.29830021
53	negative regulation of sterol transport (GO:0032372)	4.29830021
54	protein-lipid complex remodeling (GO:0034368)	4.28757931
55	macromolecular complex remodeling (GO:0034367)	4.28757931
56	plasma lipoprotein particle remodeling (GO:0034369)	4.28757931
57	tyrosine metabolic process (GO:0006570)	4.25619967
58	flavonoid metabolic process (GO:0009812)	4.23730498
59	triglyceride homeostasis (GO:0070328)	4.22818868
60	acylglycerol homeostasis (GO:0055090)	4.22818868
61	drug catabolic process (GO:0042737)	4.21658069
62	xenobiotic catabolic process (GO:0042178)	4.17964543
63	ethanol metabolic process (GO:0006067)	4.17029965
64	bile acid and bile salt transport (GO:0015721)	4.12732421
65	serine family amino acid metabolic process (GO:0009069)	4.12359190
66	coenzyme catabolic process (GO:0009109)	4.11812475
67	cellular modified amino acid catabolic process (GO:0042219)	4.11697835
68	lysine metabolic process (GO:0006553)	4.11553191
69	lysine catabolic process (GO:0006554)	4.11553191
70	fibrinolysis (GO:0042730)	4.08524852
71	exogenous drug catabolic process (GO:0042738)	4.06384139
72	amine catabolic process (GO:0009310)	4.05724246
73	cellular biogenic amine catabolic process (GO:0042402)	4.05724246
74	cellular amino acid catabolic process (GO:0009063)	4.03976372
75	arginine metabolic process (GO:0006525)	4.02737872
76	indolalkylamine metabolic process (GO:0006586)	4.01860005
77	plasma lipoprotein particle clearance (GO:0034381)	3.98262332
78	oxidative demethylation (GO:0070989)	3.97038976
79	aldehyde catabolic process (GO:0046185)	3.96830170
80	omega-hydroxylase P450 pathway (GO:0097267)	3.94684537
81	negative regulation of lipase activity (GO:0060192)	3.87450594
82	cholesterol efflux (GO:0033344)	3.82781562
83	imidazole-containing compound metabolic process (GO:0052803)	3.81231234
84	regulation of plasminogen activation (GO:0010755)	3.80029704
85	regulation of bile acid biosynthetic process (GO:0070857)	3.76697566
86	ethanol oxidation (GO:0006069)	3.73152072
87	glutamate metabolic process (GO:0006536)	3.72703281
88	biotin metabolic process (GO:0006768)	3.71392193
89	plasma lipoprotein particle assembly (GO:0034377)	3.70683391
90	serine family amino acid biosynthetic process (GO:0009070)	3.69610582
91	cofactor catabolic process (GO:0051187)	3.66635546
92	intestinal cholesterol absorption (GO:0030299)	3.61017511
93	regulation of cholesterol homeostasis (GO:2000188)	3.60649484
94	cholesterol homeostasis (GO:0042632)	3.58804472
95	cytolysis (GO:0019835)	3.58442242
96	positive regulation of triglyceride lipase activity (GO:0061365)	3.57775034
97	positive regulation of lipoprotein lipase activity (GO:0051006)	3.57775034
98	carboxylic acid catabolic process (GO:0046395)	3.57046979
99	organic acid catabolic process (GO:0016054)	3.57046979
100	blood coagulation, intrinsic pathway (GO:0007597)	3.55511656
101	phospholipid homeostasis (GO:0055091)	3.55047641
102	very-low-density lipoprotein particle assembly (GO:0034379)	3.54551140
103	negative regulation of hemostasis (GO:1900047)	3.54465376
104	negative regulation of blood coagulation (GO:0030195)	3.54465376
105	cellular ketone body metabolic process (GO:0046950)	3.54203080
106	positive regulation of lipid catabolic process (GO:0050996)	3.53725777
107	complement activation, classical pathway (GO:0006958)	3.52982819
108	sterol homeostasis (GO:0055092)	3.52895952
109	drug metabolic process (GO:0017144)	3.52098099
110	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.50497732
111	complement activation (GO:0006956)	3.49620274
112	protein activation cascade (GO:0072376)	3.48366280
113	heme transport (GO:0015886)	3.48154843
114	triglyceride catabolic process (GO:0019433)	3.44066045
115	low-density lipoprotein particle clearance (GO:0034383)	3.33283741
116	fat-soluble vitamin biosynthetic process (GO:0042362)	3.30949623
117	acylglycerol catabolic process (GO:0046464)	3.27494577
118	neutral lipid catabolic process (GO:0046461)	3.27494577
119	primary alcohol metabolic process (GO:0034308)	3.26760774
120	acetyl-CoA metabolic process (GO:0006084)	3.26578931
121	negative regulation of coagulation (GO:0050819)	3.25460828
122	negative regulation of wound healing (GO:0061045)	3.21990279
123	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.21797031
124	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.15924317
125	regulation of cholesterol biosynthetic process (GO:0045540)	3.12059649
126	drug transmembrane transport (GO:0006855)	3.01605145
127	retinal metabolic process (GO:0042574)	3.00849168
128	carnitine metabolic process (GO:0009437)	2.94210693
129	response to mercury ion (GO:0046689)	2.93593580
130	negative regulation of protein activation cascade (GO:2000258)	2.90535405
131	alkaloid metabolic process (GO:0009820)	2.88628118
132	hormone catabolic process (GO:0042447)	2.88319935
133	acute-phase response (GO:0006953)	2.85113370
134	glycoside metabolic process (GO:0016137)	2.82176780
135	desmosome organization (GO:0002934)	2.81682942
136	xenobiotic metabolic process (GO:0006805)	2.81342956
137	negative regulation of fatty acid metabolic process (GO:0045922)	2.79377650
138	S-adenosylmethionine metabolic process (GO:0046500)	2.78981807
139	regulation of cholesterol metabolic process (GO:0090181)	2.76969861
140	very long-chain fatty acid metabolic process (GO:0000038)	2.74996631

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* RXR_22158963_ChIP-Seq_LIVER_Mouse	8.00824832
2	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.80113801
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.50574951
4	* LXR_22158963_ChIP-Seq_LIVER_Mouse	6.10077912
5	* FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.89132765
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.84426662
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.67286060
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.88292767
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.38620031
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.42729728
11	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.30529228
12	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.17721260
13	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.12330593
14	CLOCK_20551151_ChIP-Seq_293T_Human	2.08792663
15	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.02801395
16	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.00640741
17	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.1791300
18	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.99903087
19	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.92712118
20	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.76657876
21	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.67728904
22	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.61684583
23	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.57860803
24	* RUNX1_27514584_Chip-Seq_MCF-7_Human	1.44708099
25	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.40084007
26	* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.35656889
27	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.35020003
28	* FOXA2_19822575_ChIP-Seq_HepG2_Human	1.33784139
29	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.32557203
30	* AHR_22903824_ChIP-Seq_MCF-7_Human	1.30792335
31	* SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.28569796
32	* SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.28569796
33	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.28030947
34	* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.27328740
35	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.27073834
36	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.23869255
37	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.22834444
38	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.17651279
39	* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.16372434
40	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.12730334
41	ZNF263_19887448_ChIP-Seq_K562_Human	1.09616539
42	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.09015976
43	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.05450168
44	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.04353907
45	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.02254183
46	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.01401219
47	GATA4_25053715_ChIP-Seq_YYC3_Human	1.00793216
48	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.99930951
49	CJUN_26792858_Chip-Seq_BT549_Human	0.99558943
50	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.99330778
51	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.96042369
52	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.96042369
53	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.95404779
54	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95025949
55	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.94197712
56	AR_21909140_ChIP-Seq_LNCAP_Human	0.93284399
57	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.91357987
58	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.90822659
59	* SMC4_20622854_ChIP-Seq_HELA_Human	0.90588849
60	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.90233330
61	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.88408428
62	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.87950178
63	* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.87390972
64	* NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.86554216
65	* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.86554216
66	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.86465972
67	EGR1_19032775_ChIP-ChIP_M12_Human	0.83641765
68	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.83279115
69	KLF5_25053715_ChIP-Seq_YYC3_Human	0.83123565
70	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.82978094
71	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.81990967
72	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.81296212
73	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.80819307
74	* ARNT_22903824_ChIP-Seq_MCF-7_Human	0.80256543
75	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.79430534
76	SOX2_20726797_ChIP-Seq_SW620_Human	0.79108739
77	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.79077740
78	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.78187882
79	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.77080644
80	CTCF_27219007_Chip-Seq_Bcells_Human	0.75830638
81	* LXR_22292898_ChIP-Seq_THP-1_Human	0.75746977
82	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.74764085
83	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.74060726
84	TP53_22127205_ChIP-Seq_IMR90_Human	0.74005355
85	* RACK7_27058665_Chip-Seq_MCF-7_Human	0.73830969
86	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.73645192
87	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.72158222
88	GATA1_22025678_ChIP-Seq_K562_Human	0.72049126
89	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.71817411
90	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.71777102
91	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.71084088
92	* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.70729351
93	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.68406914
94	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.66824451
95	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.66334883
96	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.65975587
97	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.65975587
98	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.65975587
99	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.65877555
100	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.64760776
101	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.64685902
102	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.64147775
103	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.62544025
104	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.61021289
105	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.60925144
106	* GATA6_25053715_ChIP-Seq_YYC3_Human	0.59802125
107	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.58744038
108	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.58229411
109	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.58210159
110	ATF3_27146783_Chip-Seq_COLON_Human	0.57167080
111	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.56490295
112	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.55254260
113	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.54980736
114	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.53494330
115	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.53263406
116	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.53035245
117	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.52318776
118	* GATA3_24758297_ChIP-Seq_MCF-7_Human	0.52144837
119	* TP53_20018659_ChIP-ChIP_R1E_Mouse	0.51946770
120	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.51234094
121	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.50506987
122	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.50276938
123	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.48873503
124	ERG_20517297_ChIP-Seq_VCAP_Human	0.48441009
125	* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.47405654
126	* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.46600184
127	* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.46580572
128	AR_20517297_ChIP-Seq_VCAP_Human	0.46175482
129	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.45877338
130	CEBPB_22108803_ChIP-Seq_LS180_Human	0.45836666
131	* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.45157261
132	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.44853143
133	CREB1_26743006_Chip-Seq_LNCaP_Human	0.43846544
134	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.43707994
135	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.43587567
136	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.43179014

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.71485105
2	MP0005360_urolithiasis	6.98438648
3	MP0005085_abnormal_gallbladder_physiolo	5.96456403
4	MP0005365_abnormal_bile_salt	5.51371864
5	MP0008875_abnormal_xenobiotic_pharmacok	5.50961819
6	MP0003806_abnormal_nucleotide_metabolis	3.81157354
7	MP0003252_abnormal_bile_duct	3.72081075
8	MP0009840_abnormal_foam_cell	3.31692144
9	MP0010329_abnormal_lipoprotein_level	3.18536819
10	MP0005083_abnormal_biliary_tract	2.71995233
11	MP0005332_abnormal_amino_acid	2.55903206
12	MP0003195_calcinosis	2.40583986
13	MP0001666_abnormal_nutrient_absorption	2.37971112
14	MP0004019_abnormal_vitamin_homeostasis	2.18418090
15	MP0003705_abnormal_hypodermis_morpholog	2.05567933
16	MP0003191_abnormal_cellular_cholesterol	1.98155154
17	MP0003868_abnormal_feces_composition	1.95235532
18	MP0000609_abnormal_liver_physiology	1.95144116
19	MP0001661_extended_life_span	1.89652734
20	MP0002118_abnormal_lipid_homeostasis	1.79173728
21	MP0005319_abnormal_enzyme/_coenzyme	1.72009509
22	MP0002138_abnormal_hepatobiliary_system	1.67911460
23	MP0003186_abnormal_redox_activity	1.45434295
24	MP0009053_abnormal_anal_canal	1.39987894
25	MP0009697_abnormal_copulation	1.38869906
26	MP0010234_abnormal_vibrissa_follicle	1.35292344
27	MP0003011_delayed_dark_adaptation	1.33671456
28	MP0005375_adipose_tissue_phenotype	1.32912455
29	MP0009379_abnormal_foot_pigmentation	1.32874131
30	MP0000467_abnormal_esophagus_morphology	1.30379121
31	MP0002098_abnormal_vibrissa_morphology	1.30203530
32	MP0010368_abnormal_lymphatic_system	1.28992793
33	MP0001764_abnormal_homeostasis	1.27816158
34	MP0002254_reproductive_system_inflammat	1.27245681
35	MP0003941_abnormal_skin_development	1.24349600
36	MP0008438_abnormal_cutaneous_collagen	1.23702918
37	MP0005584_abnormal_enzyme/coenzyme_acti	1.22496465
38	MP0005408_hypopigmentation	1.21653582
39	MP0005084_abnormal_gallbladder_morpholo	1.20887223
40	MP0000566_synostosis	1.18920769
41	MP0005501_abnormal_skin_physiology	1.18503673
42	MP0000598_abnormal_liver_morphology	1.16917578
43	MP0005076_abnormal_cell_differentiation	1.14225948
44	MP0009643_abnormal_urine_homeostasis	1.13963574
45	MP0002970_abnormal_white_adipose	1.11732149
46	MP0004185_abnormal_adipocyte_glucose	1.10903223
47	MP0004264_abnormal_extraembryonic_tissu	1.10778532
48	MP0005647_abnormal_sex_gland	1.07970768
49	MP0006138_congestive_heart_failure	1.04918108
50	MP0009384_cardiac_valve_regurgitation	1.03467845
51	MP0003656_abnormal_erythrocyte_physiolo	1.01272706
52	MP0005451_abnormal_body_composition	1.00017340
53	MP0005670_abnormal_white_adipose	0.96260650
54	MP0003959_abnormal_lean_body	0.95762603
55	MP0004130_abnormal_muscle_cell	0.94673747
56	MP0004858_abnormal_nervous_system	0.94494254
57	MP0009764_decreased_sensitivity_to	0.94151218
58	MP0009763_increased_sensitivity_to	0.93916496
59	MP0000762_abnormal_tongue_morphology	0.92235917
60	MP0004233_abnormal_muscle_weight	0.91228065
61	MP0000003_abnormal_adipose_tissue	0.90074392
62	MP0005248_abnormal_Harderian_gland	0.88570852
63	MP0003878_abnormal_ear_physiology	0.87647625
64	MP0005377_hearing/vestibular/ear_phenot	0.87647625
65	MP0004381_abnormal_hair_follicle	0.86861889
66	MP0005636_abnormal_mineral_homeostasis	0.78692698
67	MP0005023_abnormal_wound_healing	0.78226824
68	MP0010030_abnormal_orbit_morphology	0.77416743
69	MP0000462_abnormal_digestive_system	0.76971584
70	MP0005409_darkened_coat_color	0.76966278
71	MP0001849_ear_inflammation	0.76059427
72	MP0001881_abnormal_mammary_gland	0.75521868
73	MP0008469_abnormal_protein_level	0.74817169
74	MP0000627_abnormal_mammary_gland	0.73989579
75	MP0009642_abnormal_blood_homeostasis	0.73799901
76	MP0005275_abnormal_skin_tensile	0.71758460
77	MP0001216_abnormal_epidermal_layer	0.71408247
78	MP0009780_abnormal_chondrocyte_physiolo	0.71182533
79	MP0002249_abnormal_larynx_morphology	0.71113771
80	MP0002060_abnormal_skin_morphology	0.70946807
81	MP0005395_other_phenotype	0.68686466
82	MP0005220_abnormal_exocrine_pancreas	0.67197966
83	MP0009765_abnormal_xenobiotic_induced	0.67009070
84	MP0002697_abnormal_eye_size	0.66614941
85	MP0005376_homeostasis/metabolism_phenot	0.66391398
86	MP0010771_integument_phenotype	0.65881505
87	MP0002108_abnormal_muscle_morphology	0.65593623
88	MP0003279_aneurysm	0.65234771
89	MP0003724_increased_susceptibility_to	0.63889354
90	MP0000383_abnormal_hair_follicle	0.63681156
91	MP0002909_abnormal_adrenal_gland	0.63346930
92	MP0002089_abnormal_postnatal_growth/wei	0.61837289
93	MP0003718_maternal_effect	0.61523477
94	MP0005058_abnormal_lysosome_morphology	0.61447975
95	MP0005503_abnormal_tendon_morphology	0.60830506
96	MP0002971_abnormal_brown_adipose	0.60059443
97	MP0001756_abnormal_urination	0.59427563
98	MP0000377_abnormal_hair_follicle	0.59399516
99	MP0000537_abnormal_urethra_morphology	0.59371943
100	MP0002876_abnormal_thyroid_physiology	0.59214365
101	MP0003950_abnormal_plasma_membrane	0.58130106
102	MP0002168_other_aberrant_phenotype	0.57425388
103	MP0004782_abnormal_surfactant_physiolog	0.57320334
104	MP0010678_abnormal_skin_adnexa	0.56521443
105	MP0005508_abnormal_skeleton_morphology	0.56370650
106	MP0005334_abnormal_fat_pad	0.56157344
107	MP0003453_abnormal_keratinocyte_physiol	0.55645675
108	MP0001243_abnormal_dermal_layer	0.54021450
109	MP0002928_abnormal_bile_duct	0.50837530
110	MP0002295_abnormal_pulmonary_circulatio	0.50470442
111	MP0002078_abnormal_glucose_homeostasis	0.48882551
112	MP0005266_abnormal_metabolism	0.48252512
113	MP0000604_amyloidosis	0.47524418
114	MP0000579_abnormal_nail_morphology	0.46057743
115	MP0002136_abnormal_kidney_physiology	0.45948573
116	MP0001542_abnormal_bone_strength	0.45024632
117	MP0005666_abnormal_adipose_tissue	0.44767772
118	MP0003436_decreased_susceptibility_to	0.43282442
119	MP0002796_impaired_skin_barrier	0.43079487
120	MP0002135_abnormal_kidney_morphology	0.41524742
121	MP0000767_abnormal_smooth_muscle	0.39291212
122	MP0008873_increased_physiological_sensi	0.39178403
123	MP0002282_abnormal_trachea_morphology	0.38783426
124	MP0005166_decreased_susceptibility_to	0.38165268
125	MP0005257_abnormal_intraocular_pressure	0.38093062
126	MP0009115_abnormal_fat_cell	0.37377605
127	MP0006036_abnormal_mitochondrial_physio	0.36939043
128	MP0003638_abnormal_response/metabolism_	0.36555092
129	MP0005197_abnormal_uvea_morphology	0.36373963
130	MP0000639_abnormal_adrenal_gland	0.34153976
131	MP0005164_abnormal_response_to	0.33838125
132	MP0001915_intracranial_hemorrhage	0.33478921
133	MP0004272_abnormal_basement_membrane	0.33415183
134	MP0000163_abnormal_cartilage_morphology	0.32928769
135	MP0000249_abnormal_blood_vessel	0.32489467
136	MP0003942_abnormal_urinary_system	0.32067588
137	MP0009672_abnormal_birth_weight	0.31945941
138	MP0003566_abnormal_cell_adhesion	0.31895208
139	MP0003115_abnormal_respiratory_system	0.31569239
140	MP0000613_abnormal_salivary_gland	0.30624628

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of monocarboxylic acid metabolism (HP:0010996)	7.02017272
2	Deep venous thrombosis (HP:0002625)	7.01383868
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.00298172
4	Intrahepatic cholestasis (HP:0001406)	6.85074188
5	Xanthomatosis (HP:0000991)	6.33759891
6	Hypobetalipoproteinemia (HP:0003563)	6.00202453
7	Prolonged partial thromboplastin time (HP:0003645)	5.96850560
8	Complement deficiency (HP:0004431)	5.33251640
9	Hyperlipoproteinemia (HP:0010980)	5.21959454
10	Hypolipoproteinemia (HP:0010981)	4.67463429
11	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.56092226
12	Joint hemorrhage (HP:0005261)	4.52172722
13	Hyperglycinemia (HP:0002154)	4.37804176
14	Epidermoid cyst (HP:0200040)	4.30939838
15	Hypoalphalipoproteinemia (HP:0003233)	4.26256577
16	Hyperammonemia (HP:0001987)	4.24737153
17	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.20816702
18	Abnormality of complement system (HP:0005339)	4.10916319
19	Abnormality of the common coagulation pathway (HP:0010990)	4.02076438
20	Hyperglycinuria (HP:0003108)	4.02033461
21	Fat malabsorption (HP:0002630)	3.98854848
22	Abnormality of methionine metabolism (HP:0010901)	3.97306694
23	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.93087665
24	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.86353956
25	Abnormality of pyrimidine metabolism (HP:0004353)	3.83074949
26	Abnormality of glycine metabolism (HP:0010895)	3.77581047
27	Abnormality of serine family amino acid metabolism (HP:0010894)	3.77581047
28	Ketosis (HP:0001946)	3.61154959
29	Hypercholesterolemia (HP:0003124)	3.51643732
30	Abnormality of the intrinsic pathway (HP:0010989)	3.41861940
31	Hypoglycemic coma (HP:0001325)	3.39280067
32	Hemorrhage of the eye (HP:0011885)	3.31078484
33	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.15417720
34	Myocardial infarction (HP:0001658)	3.13797867
35	Abnormality of fatty-acid metabolism (HP:0004359)	3.06745220
36	Conjugated hyperbilirubinemia (HP:0002908)	3.05895482
37	Steatorrhea (HP:0002570)	3.02633533
38	Hyperbilirubinemia (HP:0002904)	3.01783926
39	Abnormality of serum amino acid levels (HP:0003112)	2.97100513
40	Hepatocellular carcinoma (HP:0001402)	2.95723180
41	Abnormality of nucleobase metabolism (HP:0010932)	2.88651810
42	Vascular calcification (HP:0004934)	2.75203941
43	Back pain (HP:0003418)	2.74933338
44	Delayed CNS myelination (HP:0002188)	2.74125049
45	Systemic lupus erythematosus (HP:0002725)	2.72991602
46	Skin nodule (HP:0200036)	2.67021623
47	Cardiovascular calcification (HP:0011915)	2.65147499
48	Mitral stenosis (HP:0001718)	2.62076533
49	Malnutrition (HP:0004395)	2.61490150
50	Spontaneous abortion (HP:0005268)	2.59181295
51	Late onset (HP:0003584)	2.53920771
52	Neonatal onset (HP:0003623)	2.49429004
53	Protrusio acetabuli (HP:0003179)	2.47202373
54	Lethargy (HP:0001254)	2.46379805
55	Glomerulonephritis (HP:0000099)	2.45971181
56	Abnormality of purine metabolism (HP:0004352)	2.41440240
57	Metabolic acidosis (HP:0001942)	2.40492176
58	Bifid scrotum (HP:0000048)	2.38653770
59	Esophageal varix (HP:0002040)	2.37178206
60	Vertebral compression fractures (HP:0002953)	2.37036115
61	Menorrhagia (HP:0000132)	2.35845654
62	Spastic diplegia (HP:0001264)	2.33318648
63	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.32575664
64	Dicarboxylic aciduria (HP:0003215)	2.32575664
65	Abnormality of the Achilles tendon (HP:0005109)	2.31554677
66	Rickets (HP:0002748)	2.30915094
67	Ketoacidosis (HP:0001993)	2.30824431
68	Acanthosis nigricans (HP:0000956)	2.30422221
69	Peritonitis (HP:0002586)	2.28177610
70	Irritability (HP:0000737)	2.24050499
71	Abnormal cartilage morphology (HP:0002763)	2.22849676
72	Acanthocytosis (HP:0001927)	2.17458637
73	Hydroxyprolinuria (HP:0003080)	2.13791540
74	Abnormality of proline metabolism (HP:0010907)	2.13791540
75	Opisthotonus (HP:0002179)	2.13779372
76	Pancreatitis (HP:0001733)	2.10027316
77	Osteomalacia (HP:0002749)	2.08772558
78	Cerebral edema (HP:0002181)	2.06607772
79	Hypochromic microcytic anemia (HP:0004840)	2.05942197
80	Amyloidosis (HP:0011034)	2.05449494
81	Abnormal gallbladder morphology (HP:0012437)	2.04789998
82	Ulnar bowing (HP:0003031)	2.04727402
83	Hypophosphatemic rickets (HP:0004912)	2.04722952
84	Recurrent gram-negative bacterial infections (HP:0005420)	2.04471753
85	Short nail (HP:0001799)	2.04202531
86	Cholelithiasis (HP:0001081)	2.04001869
87	Abnormal gallbladder physiology (HP:0012438)	2.03813712
88	Cholecystitis (HP:0001082)	2.03813712
89	Gout (HP:0001997)	2.03429507
90	Enlarged kidneys (HP:0000105)	1.97699050
91	Abnormal delivery (HP:0001787)	1.96445667
92	Flat acetabular roof (HP:0003180)	1.96112058
93	Arterial tortuosity (HP:0005116)	1.94820336
94	Gingival bleeding (HP:0000225)	1.94164371
95	Nephritis (HP:0000123)	1.92230565
96	Cervical subluxation (HP:0003308)	1.91602263
97	Generalized aminoaciduria (HP:0002909)	1.91342810
98	Pseudobulbar signs (HP:0002200)	1.91132514
99	Bronchomalacia (HP:0002780)	1.90214389
100	Vomiting (HP:0002013)	1.90199941
101	Hypoglycemic seizures (HP:0002173)	1.89818692
102	Reduced antithrombin III activity (HP:0001976)	1.88462478
103	Polycythemia (HP:0001901)	1.87790860
104	Brushfield spots (HP:0001088)	1.87541280
105	Vascular tortuosity (HP:0004948)	1.87190497
106	Alkalosis (HP:0001948)	1.86721792
107	Right ventricular cardiomyopathy (HP:0011663)	1.86386855
108	Hypertriglyceridemia (HP:0002155)	1.85368506
109	Abnormality of transition element cation homeostasis (HP:0011030)	1.84372157
110	Premature rupture of membranes (HP:0001788)	1.83912288
111	Abnormality of iron homeostasis (HP:0011031)	1.83781467
112	Abnormality of carpal bone ossification (HP:0006257)	1.83054637
113	Sensorimotor neuropathy (HP:0007141)	1.82655150
114	Advanced eruption of teeth (HP:0006288)	1.81935506
115	Septate vagina (HP:0001153)	1.80375606
116	Abnormality of the gallbladder (HP:0005264)	1.79356345
117	Blue sclerae (HP:0000592)	1.75811638
118	Thrombophlebitis (HP:0004418)	1.75612355
119	Abnormal enzyme/coenzyme activity (HP:0012379)	1.74635232
120	Increased mean platelet volume (HP:0011877)	1.73032394
121	Poikilocytosis (HP:0004447)	1.72889683
122	Glycosuria (HP:0003076)	1.72764049
123	Atrophic scars (HP:0001075)	1.72627942
124	Abdominal distention (HP:0003270)	1.71532735
125	Aortic dissection (HP:0002647)	1.71483869
126	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.69770320
127	Osteolytic defects of the hand bones (HP:0009699)	1.69770320
128	Hypotrichosis (HP:0001006)	1.66064547
129	Focal segmental glomerulosclerosis (HP:0000097)	1.64999142
130	Abnormal tarsal ossification (HP:0008369)	1.61258079
131	Microglossia (HP:0000171)	1.60950763
132	Asymmetry of the thorax (HP:0001555)	1.59168304
133	Achilles tendon contracture (HP:0001771)	1.59078731
134	Lymphangioma (HP:0100764)	1.58401279
135	Pterygium (HP:0001059)	1.58035079
136	Reticulocytosis (HP:0001923)	1.57840549
137	Abnormality of the gastric mucosa (HP:0004295)	1.57280149
138	Ankle contracture (HP:0006466)	1.56387125
139	Cerebral aneurysm (HP:0004944)	1.56312156
140	Natal tooth (HP:0000695)	1.54354466
141	Glomerulosclerosis (HP:0000096)	1.52717771
142	Mucopolysacchariduria (HP:0008155)	1.52636460
143	Urinary glycosaminoglycan excretion (HP:0003541)	1.52636460
144	Shallow orbits (HP:0000586)	1.51541743
145	J-shaped sella turcica (HP:0002680)	1.51290944
146	Abnormal hair laboratory examination (HP:0003328)	1.51199489
147	Fragile skin (HP:0001030)	1.50824046
148	Abnormality of vitamin metabolism (HP:0100508)	1.49419416
149	Abnormal ossification of hand bones (HP:0005921)	1.48780842

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	5.55239557
2	ERN1	4.44336388
3	SIK1	3.68201403
4	FGFR4	3.07399289
5	ERBB4	2.86982702
6	EPHA2	2.53724174
7	MST1R	2.43554605
8	NME2	2.34136716
9	MAPKAPK3	2.23113514
10	TRIB3	2.20769746
11	NEK9	2.19930411
12	ICK	2.00453573
13	LATS1	1.98755547
14	MAP3K3	1.94481864
15	PKN2	1.90846079
16	MAPK11	1.77205594
17	SMG1	1.66411740
18	PAK4	1.60485330
19	INSRR	1.59872072
20	LMTK2	1.57944262
21	EPHB2	1.57267418
22	RPS6KB2	1.55102685
23	MAP2K3	1.52122043
24	ABL2	1.50428779
25	TESK1	1.47525231
26	STK38L	1.45121960
27	DYRK1B	1.42608399
28	EEF2K	1.39843404
29	MUSK	1.38175547
30	CDK6	1.37460584
31	MAP3K11	1.34707014
32	GRK6	1.34061977
33	CDK12	1.33247495
34	TAOK3	1.33072821
35	FRK	1.26689771
36	KDR	1.25786945
37	TGFBR2	1.24783373
38	PRKD2	1.23700227
39	TAOK2	1.22559689
40	BMX	1.22078721
41	EPHA3	1.19877077
42	LATS2	1.18790882
43	PTK6	1.16845212
44	MAP2K4	1.16085837
45	TBK1	1.13939528
46	MAP3K10	1.13471823
47	DDR2	1.11358746
48	MAPK4	1.09146147
49	PIK3CG	1.04550955
50	MET	1.04195823
51	PRKG2	0.98858622
52	FLT3	0.96525566
53	STK38	0.95505020
54	MAP3K2	0.94583782
55	MAP2K6	0.91243201
56	TYK2	0.91077566
57	ERBB2	0.90366105
58	MAPK15	0.88504777
59	PTK2	0.86688053
60	MELK	0.85001992
61	SCYL2	0.83475147
62	MAP3K6	0.83226086
63	MAP2K2	0.82503108
64	JAK2	0.82068407
65	CSK	0.81757822
66	MYLK	0.81506813
67	PIK3CA	0.80598271
68	ILK	0.79724786
69	NTRK1	0.79539541
70	FER	0.79034697
71	PRKAA2	0.78329997
72	PIM1	0.78107756
73	MAP3K7	0.77557329
74	GSK3A	0.77225295
75	IRAK3	0.76929289
76	RPS6KA4	0.76926412
77	EPHB1	0.74726895
78	CDK7	0.71517183
79	PIM2	0.71108596
80	ARAF	0.69743098
81	NLK	0.68983440
82	MAP3K14	0.68600306
83	PDPK1	0.68530472
84	IKBKE	0.67371570
85	PRKAA1	0.67226831
86	MAPK12	0.65592662
87	PINK1	0.65004829
88	TTN	0.63773136
89	CAMK2G	0.63009583
90	TESK2	0.61904137
91	RIPK1	0.60533875
92	PDK2	0.60393931
93	RET	0.56891700
94	CAMK1G	0.52511254
95	NEK6	0.52124746
96	CDK8	0.51667213
97	PDGFRA	0.51331061
98	CDK9	0.50750971
99	SGK3	0.50203390
100	TAOK1	0.50148828
101	CDK4	0.49852558
102	RPS6KA2	0.48677171
103	MAP2K1	0.47862261
104	IKBKB	0.47324544
105	MAPKAPK2	0.46772756
106	PAK2	0.45940695
107	FGFR3	0.43119883
108	STK3	0.42581920
109	MAP3K12	0.42412904
110	TIE1	0.41403227
111	PRKCZ	0.41188540
112	CSNK1G1	0.40817665
113	IRAK1	0.40501845
114	TLK1	0.40106171
115	AKT3	0.40014617
116	PRKCI	0.39428620
117	MTOR	0.38748295
118	MAP3K9	0.38695709
119	PRKACG	0.38667223
120	PDGFRB	0.38195521
121	CAMK2B	0.37798305
122	AKT2	0.37178223
123	JAK1	0.37171275
124	MAPK7	0.36628346
125	CAMK1D	0.35841189
126	SGK2	0.35701574
127	ACVR1B	0.35311722
128	ABL1	0.34230255
129	CHUK	0.33753892
130	PBK	0.33586180
131	CDC42BPA	0.33271380
132	LIMK1	0.33002585
133	EIF2AK1	0.32906581
134	PRPF4B	0.32659854
135	MAP3K1	0.31799677
136	TRPM7	0.31618359
137	IGF1R	0.30556461
138	PRKD1	0.29496997
139	MAP3K5	0.29087386
140	CAMK2D	0.27950899
141	KSR2	0.25360273
142	RPS6KC1	0.24747379

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.41108127
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.71626618
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.20785297
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.98412120
5	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.88674251
6	Arginine biosynthesis_Homo sapiens_hsa00220	2.87711799
7	Complement and coagulation cascades_Homo sapiens_hsa04610	2.71875564
8	Tryptophan metabolism_Homo sapiens_hsa00380	2.63183656
9	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.57545532
10	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.48033188
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.45612817
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.45192262
13	Chemical carcinogenesis_Homo sapiens_hsa05204	2.40772688
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.37730552
15	Caffeine metabolism_Homo sapiens_hsa00232	2.28823510
16	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.28207332
17	Fatty acid degradation_Homo sapiens_hsa00071	2.23626904
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.14603579
19	Peroxisome_Homo sapiens_hsa04146	1.97182123
20	Retinol metabolism_Homo sapiens_hsa00830	1.95402150
21	Butanoate metabolism_Homo sapiens_hsa00650	1.88618500
22	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.87438455
23	Histidine metabolism_Homo sapiens_hsa00340	1.80373987
24	PPAR signaling pathway_Homo sapiens_hsa03320	1.77124189
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.64029143
26	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.58832877
27	Sulfur metabolism_Homo sapiens_hsa00920	1.58728378
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.58009922
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.57434977
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.56830438
31	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.53064544
32	Propanoate metabolism_Homo sapiens_hsa00640	1.52403099
33	Phenylalanine metabolism_Homo sapiens_hsa00360	1.48517763
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.46062994
35	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.45463573
36	Bile secretion_Homo sapiens_hsa04976	1.43885690
37	Sulfur relay system_Homo sapiens_hsa04122	1.39289987
38	Tyrosine metabolism_Homo sapiens_hsa00350	1.29823357
39	Folate biosynthesis_Homo sapiens_hsa00790	1.27849659
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.24792866
41	Fat digestion and absorption_Homo sapiens_hsa04975	1.24332490
42	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.21228923
43	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.21158106
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.19711572
45	ABC transporters_Homo sapiens_hsa02010	1.09093405
46	Pyruvate metabolism_Homo sapiens_hsa00620	1.07608442
47	Glutathione metabolism_Homo sapiens_hsa00480	1.07320915
48	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.05724948
49	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.04824845
50	Fatty acid elongation_Homo sapiens_hsa00062	1.03288106
51	Steroid biosynthesis_Homo sapiens_hsa00100	1.02355935
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00123450
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.98018262
54	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.95120075
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.95055086
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.94248242
57	Carbon metabolism_Homo sapiens_hsa01200	0.93927942
58	One carbon pool by folate_Homo sapiens_hsa00670	0.86503433
59	Lysine degradation_Homo sapiens_hsa00310	0.70091281
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.67805025
61	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.67678097
62	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.66894153
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64082200
64	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.61424823
65	Galactose metabolism_Homo sapiens_hsa00052	0.50310735
66	Prion diseases_Homo sapiens_hsa05020	0.47179900
67	Pentose phosphate pathway_Homo sapiens_hsa00030	0.47168251
68	Metabolic pathways_Homo sapiens_hsa01100	0.45368688
69	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.44462025
70	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.34100520
71	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33610475
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.25535645
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.23705857
74	Linoleic acid metabolism_Homo sapiens_hsa00591	0.21284063
75	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.20702224
76	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.19753934
77	Other glycan degradation_Homo sapiens_hsa00511	0.18371718
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.17418715
79	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.17115447
80	Insulin resistance_Homo sapiens_hsa04931	0.16562959
81	Focal adhesion_Homo sapiens_hsa04510	0.14968605
82	Renin-angiotensin system_Homo sapiens_hsa04614	0.13799016
83	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.12952016
84	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.12641521
85	Thyroid cancer_Homo sapiens_hsa05216	0.12229133
86	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.09390521
87	Bladder cancer_Homo sapiens_hsa05219	0.08197825
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.08153698
89	Adherens junction_Homo sapiens_hsa04520	0.07993648
90	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.07528573
91	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.07406625
92	Tight junction_Homo sapiens_hsa04530	0.06361745
93	Small cell lung cancer_Homo sapiens_hsa05222	0.05009046
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.04650643
95	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.04526448
96	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.03503311
97	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1514715
98	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1455431
99	Hepatitis C_Homo sapiens_hsa05160	-0.1428356
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	-0.1405008
101	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.1325528
102	Malaria_Homo sapiens_hsa05144	-0.1154992
103	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.1130217
104	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.0829175
105	ECM-receptor interaction_Homo sapiens_hsa04512	-0.0809318
106	Amoebiasis_Homo sapiens_hsa05146	-0.0768581
107	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	-0.0737693
108	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0674947
109	Protein digestion and absorption_Homo sapiens_hsa04974	-0.0607000
110	Basal cell carcinoma_Homo sapiens_hsa05217	-0.0408346
111	Glucagon signaling pathway_Homo sapiens_hsa04922	-0.0333248
112	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.0266204
113	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0217317
114	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0150393
115	Mineral absorption_Homo sapiens_hsa04978	-0.0129342
116	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	-0.0068297

TSKU

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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