TSLP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)5.69414236
2regulation of cytokine secretion involved in immune response (GO:0002739)5.62838473
3positive regulation of chemokine biosynthetic process (GO:0045080)5.27503345
4regulation of fever generation (GO:0031620)5.25129728
5positive regulation of heat generation (GO:0031652)5.19010088
6ribosomal small subunit assembly (GO:0000028)5.13689043
7regulation of membrane protein ectodomain proteolysis (GO:0051043)4.94571406
8response to interferon-beta (GO:0035456)4.70310401
9modulation of growth of symbiont involved in interaction with host (GO:0044144)4.68465630
10regulation of growth of symbiont in host (GO:0044126)4.68465630
11negative regulation of growth of symbiont in host (GO:0044130)4.68465630
12negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.68465630
13hemidesmosome assembly (GO:0031581)4.53116412
14neutrophil mediated immunity (GO:0002446)4.36650388
15positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.34073011
16branching involved in labyrinthine layer morphogenesis (GO:0060670)4.30345050
17cellular response to interferon-beta (GO:0035458)4.22511499
18positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.21254580
19negative regulation of nitric oxide biosynthetic process (GO:0045019)4.14769954
20adhesion of symbiont to host cell (GO:0044650)4.08436474
21virion attachment to host cell (GO:0019062)4.08436474
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.03357596
23neutrophil activation involved in immune response (GO:0002283)3.99410072
24regulation of podosome assembly (GO:0071801)3.96962409
25regulation of nitric oxide biosynthetic process (GO:0045428)3.95408430
26reactive oxygen species biosynthetic process (GO:1903409)3.94192646
27regulation of immunoglobulin secretion (GO:0051023)3.92648282
28negative regulation of interleukin-12 production (GO:0032695)3.89821742
29positive regulation of nitric oxide biosynthetic process (GO:0045429)3.88838056
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85345311
31myeloid leukocyte mediated immunity (GO:0002444)3.84429946
32regulation of T-helper 2 cell differentiation (GO:0045628)3.76742721
33cellular response to zinc ion (GO:0071294)3.75190363
34regulation of heterotypic cell-cell adhesion (GO:0034114)3.74525588
35regulation of heat generation (GO:0031650)3.72955703
36DNA deamination (GO:0045006)3.68820030
37regulation of mononuclear cell migration (GO:0071675)3.68470311
38response to peptidoglycan (GO:0032494)3.66220522
39activation of MAPKKK activity (GO:0000185)3.64021453
40mesenchymal cell differentiation involved in renal system development (GO:2001012)3.59913152
41mesenchymal cell differentiation involved in kidney development (GO:0072161)3.59913152
42regulation of T-helper 1 cell differentiation (GO:0045625)3.59655604
43negative regulation of phagocytosis (GO:0050765)3.58931760
44adhesion of symbiont to host (GO:0044406)3.52890358
45regulation of chemokine biosynthetic process (GO:0045073)3.48533658
46positive regulation of type 2 immune response (GO:0002830)3.46924619
47response to interferon-alpha (GO:0035455)3.46687397
48negative regulation of cytokine production involved in immune response (GO:0002719)3.45977574
49positive regulation of p38MAPK cascade (GO:1900745)3.42925704
50positive regulation of acute inflammatory response (GO:0002675)3.34912017
51negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.30273805
52negative regulation of amino acid transport (GO:0051956)3.29562754
53regulation of vitamin D biosynthetic process (GO:0060556)3.28018470
54disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.27415596
55killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.27415596
56positive regulation of natural killer cell differentiation (GO:0032825)3.27387911
57positive regulation of interleukin-6 production (GO:0032755)3.26309496
58positive regulation of NF-kappaB import into nucleus (GO:0042346)3.25656945
59cellular response to lipopolysaccharide (GO:0071222)3.24257985
60response to fungus (GO:0009620)3.22100001
61cell adhesion mediated by integrin (GO:0033627)3.18960646
62viral transcription (GO:0019083)3.16012112
63SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15843459
64negative regulation of viral genome replication (GO:0045071)3.15772472
65regulation of T-helper cell differentiation (GO:0045622)3.14759563
66cellular response to interferon-alpha (GO:0035457)3.14112975
67response to UV-B (GO:0010224)3.13956443
68positive regulation of lymphocyte apoptotic process (GO:0070230)3.12961527
69cellular response to nicotine (GO:0071316)3.12622464
70regulation of activation of Janus kinase activity (GO:0010533)3.12090280
71negative regulation of lipid storage (GO:0010888)3.10961329
72chronic inflammatory response (GO:0002544)3.10527812
73regulation of NF-kappaB import into nucleus (GO:0042345)3.10023197
74cellular response to molecule of bacterial origin (GO:0071219)3.07224914
75cellular response to exogenous dsRNA (GO:0071360)3.06173444
76cotranslational protein targeting to membrane (GO:0006613)3.05371925
77regulation of type 2 immune response (GO:0002828)3.05093713
78protein targeting to ER (GO:0045047)3.04734509
79regulation of type I interferon-mediated signaling pathway (GO:0060338)3.03612165
80translational termination (GO:0006415)3.01883987
81leukocyte mediated cytotoxicity (GO:0001909)3.00248815
82oligosaccharide catabolic process (GO:0009313)2.98739296
83glycosphingolipid catabolic process (GO:0046479)2.98443366
84positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.96997708
85cell differentiation involved in metanephros development (GO:0072202)2.94829568
86ovulation (GO:0030728)2.94675257
87respiratory burst (GO:0045730)2.94664103
88definitive hemopoiesis (GO:0060216)2.94486766
89fibril organization (GO:0097435)2.94434036
90monocyte chemotaxis (GO:0002548)2.94071308
91response to muramyl dipeptide (GO:0032495)2.91612117
92NIK/NF-kappaB signaling (GO:0038061)2.90277802
93positive regulation of T-helper cell differentiation (GO:0045624)2.90057260
94germinal center formation (GO:0002467)2.88686956
95establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87351193
96protein localization to endoplasmic reticulum (GO:0070972)2.86980288
97regulation of vitamin metabolic process (GO:0030656)2.86918967
98positive regulation of protein import into nucleus, translocation (GO:0033160)2.86368502
99indole-containing compound catabolic process (GO:0042436)2.86306710
100indolalkylamine catabolic process (GO:0046218)2.86306710
101tryptophan catabolic process (GO:0006569)2.86306710
102fibrinolysis (GO:0042730)2.86083892
103positive regulation of natural killer cell activation (GO:0032816)2.85358021
104defense response to protozoan (GO:0042832)2.83634469
105positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.81067396
106myeloid dendritic cell activation (GO:0001773)2.80369420
107respiratory tube development (GO:0030323)2.78617084
108regulation of interleukin-8 biosynthetic process (GO:0045414)2.77402800
109T-helper 1 type immune response (GO:0042088)2.76641954
110positive regulation of chemokine secretion (GO:0090197)2.74950506
111negative regulation of production of molecular mediator of immune response (GO:0002701)2.74814745
112decidualization (GO:0046697)2.72717350
113positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.72678343
114polyketide metabolic process (GO:0030638)2.71380899
115doxorubicin metabolic process (GO:0044598)2.71380899
116daunorubicin metabolic process (GO:0044597)2.71380899
117natural killer cell activation involved in immune response (GO:0002323)2.70741305
118type I interferon signaling pathway (GO:0060337)2.70189081
119cellular response to type I interferon (GO:0071357)2.70189081
120macrophage activation involved in immune response (GO:0002281)2.69517379
121ribosomal small subunit biogenesis (GO:0042274)2.69076051
122negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.68306864
123superoxide anion generation (GO:0042554)2.67894616
124regulation of interleukin-6 production (GO:0032675)2.67429223
125response to type I interferon (GO:0034340)2.66667658
126kynurenine metabolic process (GO:0070189)2.65908506
127positive regulation of interferon-alpha production (GO:0032727)2.65576044
128positive regulation of chemokine production (GO:0032722)2.64359379
129positive regulation of leukocyte apoptotic process (GO:2000108)2.63341669
130positive regulation of lipid storage (GO:0010884)2.63241046
131negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.61891265
132regulation of protein import into nucleus, translocation (GO:0033158)2.61655287
133cellular response to biotic stimulus (GO:0071216)2.61412383
134regulation of interleukin-12 production (GO:0032655)2.61377567
135glycolipid catabolic process (GO:0019377)2.61026850
136response to protozoan (GO:0001562)2.60952509
137interferon-gamma-mediated signaling pathway (GO:0060333)2.60659124
138dendritic cell differentiation (GO:0097028)2.60049906
139translational elongation (GO:0006414)2.60043650
140extracellular fibril organization (GO:0043206)2.59419318
141megakaryocyte development (GO:0035855)2.59271770
142response to ATP (GO:0033198)2.58624061
143negative regulation of interleukin-8 production (GO:0032717)2.57076697
144desmosome organization (GO:0002934)2.57043965
145barbed-end actin filament capping (GO:0051016)2.56876175
146antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.56580137
147antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.56580137
148positive regulation of T cell mediated cytotoxicity (GO:0001916)2.56072412
149regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.54997159
150negative regulation of myeloid cell apoptotic process (GO:0033033)2.53750137
151sequestering of actin monomers (GO:0042989)2.52450972
152positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.51332527
153negative regulation of mast cell activation (GO:0033004)2.50616570
154positive regulation of defense response to virus by host (GO:0002230)2.50319778
155Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50302427
156lipopolysaccharide-mediated signaling pathway (GO:0031663)2.49554523
157detection of molecule of bacterial origin (GO:0032490)2.48303249
158positive regulation of monocyte chemotaxis (GO:0090026)2.48005851
159hydrogen peroxide biosynthetic process (GO:0050665)2.46870488
160regulation of interleukin-12 biosynthetic process (GO:0045075)2.46840910
161regulation of RIG-I signaling pathway (GO:0039535)2.46229168
162regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.45549267
163positive regulation of interleukin-17 production (GO:0032740)2.45020502
164regulation of interferon-alpha production (GO:0032647)2.44568709
165mesodermal cell differentiation (GO:0048333)2.42549192
166regulation of T-helper 1 type immune response (GO:0002825)2.40553180
167myeloid dendritic cell differentiation (GO:0043011)2.39278062
168antigen processing and presentation of endogenous antigen (GO:0019883)2.37902993
169negative regulation of erythrocyte differentiation (GO:0045647)2.37869415
170granulocyte activation (GO:0036230)2.37814243
171positive regulation of macrophage differentiation (GO:0045651)2.37767143
172signal peptide processing (GO:0006465)2.37096558
173eosinophil chemotaxis (GO:0048245)2.37080801
174kinetochore organization (GO:0051383)2.36185407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.35477117
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.58187827
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.21539679
4E2F7_22180533_ChIP-Seq_HELA_Human3.99458917
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.86286522
6MYB_21317192_ChIP-Seq_ERMYB_Mouse3.64163135
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.37275995
8GATA1_22025678_ChIP-Seq_K562_Human3.17533219
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02088478
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81906998
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71766436
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70602574
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.64801724
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58822189
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.50633435
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49087410
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.42682336
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39550259
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36107999
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31900909
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31384503
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30144414
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.27188405
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23815232
25* SMAD_19615063_ChIP-ChIP_OVARY_Human2.23599711
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.21359648
27SPI1_23547873_ChIP-Seq_NB4_Human2.18748106
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18372346
29SCL_19346495_ChIP-Seq_HPC-7_Human2.15925312
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15667543
31IRF8_27001747_Chip-Seq_BMDM_Mouse2.14044030
32VDR_24787735_ChIP-Seq_THP-1_Human2.01282941
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96269998
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.91627859
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91111033
36ELK1_19687146_ChIP-ChIP_HELA_Human1.89659470
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.87736780
38JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86009425
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85874720
40VDR_24763502_ChIP-Seq_THP-1_Human1.84496965
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.77171762
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76001531
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.74697413
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74055483
45VDR_21846776_ChIP-Seq_THP-1_Human1.73344662
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73240926
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72524513
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71684681
49* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71154838
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70846059
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68383381
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.68359476
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67479307
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60426569
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59824040
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.59417484
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58909665
58* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58576011
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58360970
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.57710609
61* CJUN_26792858_Chip-Seq_BT549_Human1.56924201
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.54004012
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53975996
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53933121
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53558107
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53515504
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52926313
68TP53_18474530_ChIP-ChIP_U2OS_Human1.51334932
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51132132
70UBF1/2_26484160_Chip-Seq_HMECs_Human1.47512178
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46499050
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45622412
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44113649
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.43554925
75LXR_22158963_ChIP-Seq_LIVER_Mouse1.43543698
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42699505
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42065315
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41425401
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.37968903
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36717681
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.35560787
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.34956730
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34803006
84SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34803006
85LXR_22292898_ChIP-Seq_THP-1_Human1.32852204
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31926017
87PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31851625
88MYB_26560356_Chip-Seq_TH2_Human1.27628688
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25296505
90GATA1_19941826_ChIP-Seq_K562_Human1.24273965
91* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22863062
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22626796
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22369595
94MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21722057
95STAT1_20625510_ChIP-Seq_HELA_Human1.20598461
96MYB_26560356_Chip-Seq_TH1_Human1.20591247
97VDR_23849224_ChIP-Seq_CD4+_Human1.20167083
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17952816
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17312391
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15397142
101PU_27001747_Chip-Seq_BMDM_Mouse1.15175730
102NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14920928
103E2F1_21310950_ChIP-Seq_MCF-7_Human1.13517046
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13131025
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.12268785
106DCP1A_22483619_ChIP-Seq_HELA_Human1.11515152
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09891482
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09070326
109TRIM28_21343339_ChIP-Seq_HEK293_Human1.09011478
110SPI1_23127762_ChIP-Seq_K562_Human1.08319155
111SOX2_20726797_ChIP-Seq_SW620_Human1.07997102
112MAF_26560356_Chip-Seq_TH1_Human1.06930051
113MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04617613
114JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03954088
115KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03506365
116KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03506365
117KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03506365
118P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03385220
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03019609
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02773891
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02347618
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02272096
123* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01333041
124E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01284699
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99844910
126ELF1_20517297_ChIP-Seq_JURKAT_Human0.99818193
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.99017019
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98451663
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97651055
130HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97551030
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97256882
132FOXP3_21729870_ChIP-Seq_TREG_Human0.96670232
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96663903
134* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96251499
135NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95906128
136AR_21909140_ChIP-Seq_LNCAP_Human0.95483251
137CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95318686
138NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95225421
139ETS1_20019798_ChIP-Seq_JURKAT_Human0.94409234
140* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94319464
141CLOCK_20551151_ChIP-Seq_293T_Human0.91598349
142SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89166030
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86918824
144MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86596625
145BRD4_25478319_ChIP-Seq_HGPS_Human0.85234697
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85073332
147ATF3_27146783_Chip-Seq_COLON_Human0.84666807
148STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83813885
149THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83317521
150RUNX_20019798_ChIP-Seq_JUKART_Human0.82725250
151TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81793341
152TBX20_22080862_ChIP-Seq_HEART_Mouse0.80113769
153TBX20_22328084_ChIP-Seq_HEART_Mouse0.80113769
154EP300_21415370_ChIP-Seq_HL-1_Mouse0.79529578
155SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77973973
156STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.77487077
157CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77296036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis4.26236127
2MP0008438_abnormal_cutaneous_collagen3.63025282
3MP0009785_altered_susceptibility_to3.39376090
4MP0002139_abnormal_hepatobiliary_system3.16822837
5MP0003436_decreased_susceptibility_to3.16313479
6MP0002148_abnormal_hypersensitivity_rea3.15517210
7MP0003724_increased_susceptibility_to3.12428553
8MP0001835_abnormal_antigen_presentation2.97091581
9MP0002006_tumorigenesis2.96494088
10MP0005275_abnormal_skin_tensile2.96437958
11MP0008004_abnormal_stomach_pH2.88489449
12MP0005451_abnormal_body_composition2.67373237
13MP0002166_altered_tumor_susceptibility2.66162365
14MP0005058_abnormal_lysosome_morphology2.59694621
15MP0002396_abnormal_hematopoietic_system2.52568677
16MP0002332_abnormal_exercise_endurance2.50991974
17MP0003300_gastrointestinal_ulcer2.50867476
18MP0002419_abnormal_innate_immunity2.35158869
19MP0005025_abnormal_response_to2.26749997
20MP0005410_abnormal_fertilization2.26302255
21MP0005000_abnormal_immune_tolerance2.22880828
22MP0002877_abnormal_melanocyte_morpholog2.22569183
23MP0003806_abnormal_nucleotide_metabolis2.21146054
24MP0009840_abnormal_foam_cell2.17720006
25MP0002254_reproductive_system_inflammat2.14784978
26MP0002060_abnormal_skin_morphology2.09242350
27MP0008007_abnormal_cellular_replicative2.03699388
28MP0000685_abnormal_immune_system2.03085853
29MP0005671_abnormal_response_to1.93962789
30MP0010352_gastrointestinal_tract_polyps1.92451409
31MP0002009_preneoplasia1.91916355
32MP0001853_heart_inflammation1.84172189
33MP0003303_peritoneal_inflammation1.83460640
34MP0005503_abnormal_tendon_morphology1.76632922
35MP0001545_abnormal_hematopoietic_system1.72065734
36MP0005397_hematopoietic_system_phenotyp1.72065734
37MP0003566_abnormal_cell_adhesion1.71373613
38MP0009379_abnormal_foot_pigmentation1.68916067
39MP0002452_abnormal_antigen_presenting1.68155815
40MP0001542_abnormal_bone_strength1.67509709
41MP0001533_abnormal_skeleton_physiology1.65952799
42MP0003195_calcinosis1.63078113
43MP0003828_pulmonary_edema1.62843879
44MP0000465_gastrointestinal_hemorrhage1.58659368
45MP0000858_altered_metastatic_potential1.56564887
46MP0003656_abnormal_erythrocyte_physiolo1.55168972
47MP0002723_abnormal_immune_serum1.54703517
48MP0010155_abnormal_intestine_physiology1.52032440
49MP0001819_abnormal_immune_cell1.51241653
50MP0002420_abnormal_adaptive_immunity1.50567741
51MP0005464_abnormal_platelet_physiology1.49856994
52MP0002132_abnormal_respiratory_system1.49577098
53MP0006082_CNS_inflammation1.49458369
54MP0002837_dystrophic_cardiac_calcinosis1.49091764
55MP0003646_muscle_fatigue1.48950325
56MP0001851_eye_inflammation1.46638169
57MP0006054_spinal_hemorrhage1.44523704
58MP0001800_abnormal_humoral_immune1.41148816
59MP0005167_abnormal_blood-brain_barrier1.40178092
60MP0009278_abnormal_bone_marrow1.39647625
61MP0003950_abnormal_plasma_membrane1.36619451
62MP0003091_abnormal_cell_migration1.34246337
63MP0009333_abnormal_splenocyte_physiolog1.31977594
64MP0005390_skeleton_phenotype1.31396649
65MP0000343_altered_response_to1.29402511
66MP0001845_abnormal_inflammatory_respons1.29129332
67MP0005165_increased_susceptibility_to1.26701692
68MP0009764_decreased_sensitivity_to1.24987537
69MP0005023_abnormal_wound_healing1.23186654
70MP0002998_abnormal_bone_remodeling1.22820797
71MP0001879_abnormal_lymphatic_vessel1.22687419
72MP0003763_abnormal_thymus_physiology1.22105657
73MP0003705_abnormal_hypodermis_morpholog1.21106456
74MP0002138_abnormal_hepatobiliary_system1.15357694
75MP0009697_abnormal_copulation1.14792639
76MP0001346_abnormal_lacrimal_gland1.14653548
77MP0003075_altered_response_to1.14465724
78MP0002282_abnormal_trachea_morphology1.14262638
79MP0008057_abnormal_DNA_replication1.14007457
80MP0004808_abnormal_hematopoietic_stem1.13717466
81MP0002405_respiratory_system_inflammati1.12288743
82MP0010368_abnormal_lymphatic_system1.11843861
83MP0003448_altered_tumor_morphology1.11448587
84MP0005174_abnormal_tail_pigmentation1.09892524
85MP0003172_abnormal_lysosome_physiology1.09519578
86MP0002249_abnormal_larynx_morphology1.09013430
87MP0005387_immune_system_phenotype1.07935161
88MP0001790_abnormal_immune_system1.07935161
89MP0000490_abnormal_crypts_of1.07741807
90MP0002398_abnormal_bone_marrow1.07729565
91MP0010094_abnormal_chromosome_stability1.05574311
92MP0000716_abnormal_immune_system1.05237713
93MP0001216_abnormal_epidermal_layer1.02569131
94MP0005666_abnormal_adipose_tissue1.02515083
95MP0000427_abnormal_hair_cycle1.01385831
96MP0004272_abnormal_basement_membrane1.00688019
97MP0005266_abnormal_metabolism1.00380897
98MP0002095_abnormal_skin_pigmentation1.00174509
99MP0001243_abnormal_dermal_layer0.99720541
100MP0003868_abnormal_feces_composition0.99101925
101MP0005367_renal/urinary_system_phenotyp0.98069116
102MP0000516_abnormal_urinary_system0.98069116
103MP0004782_abnormal_surfactant_physiolog0.97772473
104MP0005164_abnormal_response_to0.95900523
105MP0004947_skin_inflammation0.95062627
106MP0008469_abnormal_protein_level0.94949963
107MP0002295_abnormal_pulmonary_circulatio0.94394488
108MP0008789_abnormal_olfactory_epithelium0.94365067
109MP0003453_abnormal_keratinocyte_physiol0.91327805
110MP0000604_amyloidosis0.91146788
111MP0005310_abnormal_salivary_gland0.90155357
112MP0003186_abnormal_redox_activity0.90031243
113MP0002429_abnormal_blood_cell0.89915296
114MP0001501_abnormal_sleep_pattern0.89574524
115MP0003279_aneurysm0.88790292
116MP0005508_abnormal_skeleton_morphology0.88499924
117MP0005595_abnormal_vascular_smooth0.86720229
118MP0009765_abnormal_xenobiotic_induced0.86038377
119MP0003690_abnormal_glial_cell0.85618969
120MP0003941_abnormal_skin_development0.85025180
121MP0005409_darkened_coat_color0.85003492
122MP0005365_abnormal_bile_salt0.82953473
123MP0000689_abnormal_spleen_morphology0.82377564
124MP0002722_abnormal_immune_system0.81750726
125MP0003943_abnormal_hepatobiliary_system0.81449395
126MP0010771_integument_phenotype0.80260515
127MP0000750_abnormal_muscle_regeneration0.78965669
128MP0001958_emphysema0.78779281
129MP0005623_abnormal_meninges_morphology0.78613347
130MP0009931_abnormal_skin_appearance0.78437695
131MP0001764_abnormal_homeostasis0.77142033
132MP0008058_abnormal_DNA_repair0.77041910
133MP0005166_decreased_susceptibility_to0.75656548
134MP0000249_abnormal_blood_vessel0.74972299
135MP0009053_abnormal_anal_canal0.74828866
136MP0009763_increased_sensitivity_to0.74584215
137MP0005535_abnormal_body_temperature0.74392134
138MP0005376_homeostasis/metabolism_phenot0.74274037
139MP0002019_abnormal_tumor_incidence0.74185582
140MP0005257_abnormal_intraocular_pressure0.74158890
141MP0010307_abnormal_tumor_latency0.72308878
142MP0004883_abnormal_blood_vessel0.70146183
143MP0005375_adipose_tissue_phenotype0.65762704
144MP0005647_abnormal_sex_gland0.64711437
145* MP0008874_decreased_physiological_sensi0.64301768
146MP0000749_muscle_degeneration0.62492462
147MP0000733_abnormal_muscle_development0.60644912

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.17858718
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.17858718
3Abnormality of glycolipid metabolism (HP:0010969)6.17858718
4Thrombocytosis (HP:0001894)5.64730494
5Elevated erythrocyte sedimentation rate (HP:0003565)4.80833165
6Nuclear cataract (HP:0100018)4.65670623
7Asymmetric septal hypertrophy (HP:0001670)4.22349262
8Myositis (HP:0100614)4.01495903
9Syringomyelia (HP:0003396)3.88952279
10Spinal cord lesions (HP:0100561)3.88952279
11Dysostosis multiplex (HP:0000943)3.83886966
12Disinhibition (HP:0000734)3.82281988
13Axonal loss (HP:0003447)3.72388826
14Recurrent abscess formation (HP:0002722)3.56129689
15Recurrent bacterial skin infections (HP:0005406)3.46516785
16Milia (HP:0001056)3.41191338
17Atrophic scars (HP:0001075)3.36665310
18Fragile nails (HP:0001808)3.36266397
19Petechiae (HP:0000967)3.35769951
20Loss of speech (HP:0002371)3.34351508
21Stomatitis (HP:0010280)3.31242769
22Abnormal number of erythroid precursors (HP:0012131)3.28459058
23Onycholysis (HP:0001806)3.21031284
24Abnormality of cells of the erythroid lineage (HP:0012130)3.20627773
25Reduced antithrombin III activity (HP:0001976)3.20147719
26Orchitis (HP:0100796)3.13766261
27Glomerulonephritis (HP:0000099)3.10357257
28Asymmetry of the thorax (HP:0001555)3.05865138
29Complement deficiency (HP:0004431)3.02780609
30Missing ribs (HP:0000921)3.00087621
31Abnormality of mucopolysaccharide metabolism (HP:0011020)2.97430383
32Abnormality of polysaccharide metabolism (HP:0011012)2.97430383
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.97430383
34Mucopolysacchariduria (HP:0008155)2.96960810
35Urinary glycosaminoglycan excretion (HP:0003541)2.96960810
36Generalized aminoaciduria (HP:0002909)2.96685442
37Myocardial infarction (HP:0001658)2.93790785
38Type I transferrin isoform profile (HP:0003642)2.91159117
39Nausea (HP:0002018)2.86988523
40Parakeratosis (HP:0001036)2.84988615
41Neurofibrillary tangles (HP:0002185)2.79926790
42Cutaneous melanoma (HP:0012056)2.78234301
43Periodontitis (HP:0000704)2.77084550
44Increased cerebral lipofuscin (HP:0011813)2.74534657
45Plantar hyperkeratosis (HP:0007556)2.72630059
46Eczematoid dermatitis (HP:0000976)2.68577603
47Intrahepatic cholestasis (HP:0001406)2.67605426
48Increased serum ferritin (HP:0003281)2.66938808
49Aplasia cutis congenita (HP:0001057)2.66404618
50Basal ganglia calcification (HP:0002135)2.64512498
51Vasculitis (HP:0002633)2.62472369
52Reticulocytopenia (HP:0001896)2.62202713
53Mediastinal lymphadenopathy (HP:0100721)2.61159669
54White forelock (HP:0002211)2.59014324
5511 pairs of ribs (HP:0000878)2.56775347
56Mutism (HP:0002300)2.55706258
57Eosinophilia (HP:0001880)2.55039186
58Thoracolumbar scoliosis (HP:0002944)2.53431082
59Aplastic anemia (HP:0001915)2.48099789
60Fragile skin (HP:0001030)2.45831504
61Patchy hypopigmentation of hair (HP:0011365)2.41333964
62Abnormality of complement system (HP:0005339)2.40966004
63Thick nail (HP:0001805)2.39926264
64Optic neuritis (HP:0100653)2.39490077
65Retrobulbar optic neuritis (HP:0100654)2.39490077
66Ureteral stenosis (HP:0000071)2.37991672
67Abnormality of monocarboxylic acid metabolism (HP:0010996)2.37742339
68Progressive neurologic deterioration (HP:0002344)2.36298795
69Skin ulcer (HP:0200042)2.32842969
70Abnormality of the prostate (HP:0008775)2.32299031
71Systemic lupus erythematosus (HP:0002725)2.32175457
72Ureteral obstruction (HP:0006000)2.31462590
73Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30774784
74Granulocytopenia (HP:0001913)2.28980896
75Arterial thrombosis (HP:0004420)2.28865372
76Vacuolated lymphocytes (HP:0001922)2.25151169
77Autoimmune hemolytic anemia (HP:0001890)2.23764432
78Abnormality of the pericardium (HP:0001697)2.20789448
79Abnormality of the vasculature of the conjunctiva (HP:0008054)2.17434742
80Amyloidosis (HP:0011034)2.17296976
81Dry hair (HP:0011359)2.17282455
82Thin bony cortex (HP:0002753)2.17068853
83Chronic obstructive pulmonary disease (HP:0006510)2.16362473
84Obstructive lung disease (HP:0006536)2.16362473
85Spontaneous hematomas (HP:0007420)2.15714425
86Abnormality of macrophages (HP:0004311)2.15683025
87Keratoconjunctivitis sicca (HP:0001097)2.15655779
88Cerebral inclusion bodies (HP:0100314)2.14656955
89Nephritis (HP:0000123)2.14540808
90Abnormality of the lumbar spine (HP:0100712)2.14294114
91Abnormality of the costochondral junction (HP:0000919)2.12709816
92Hyperparathyroidism (HP:0000843)2.12667094
93Ectropion (HP:0000656)2.12549147
94Pili torti (HP:0003777)2.12527206
95Increased IgM level (HP:0003496)2.12232014
96Protuberant abdomen (HP:0001538)2.10529851
97Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10070924
98Hypergammaglobulinemia (HP:0010702)2.09887821
99Recurrent gram-negative bacterial infections (HP:0005420)2.08999439
100Hematochezia (HP:0002573)2.08889960
101Chest pain (HP:0100749)2.08406247
102Polyneuropathy (HP:0001271)2.08397278
103Poor head control (HP:0002421)2.08157237
104Abnormal glycosylation (HP:0012345)2.08117202
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08117202
106Abnormal protein N-linked glycosylation (HP:0012347)2.08117202
107Abnormal protein glycosylation (HP:0012346)2.08117202
108Deep venous thrombosis (HP:0002625)2.07661021
109Gangrene (HP:0100758)2.07365290
110Autoimmune thrombocytopenia (HP:0001973)2.06649451
111Apathy (HP:0000741)2.05546205
112Severe visual impairment (HP:0001141)2.04508574
113Metaphyseal irregularity (HP:0003025)2.03116012
114Abnormal blistering of the skin (HP:0008066)2.02666928
115Leukocytosis (HP:0001974)2.02613515
116Zonular cataract (HP:0010920)2.02370211
117Prolonged bleeding time (HP:0003010)2.01618363
118Sepsis (HP:0100806)2.01593402
119Abnormality of the nasal mucosa (HP:0000433)2.01420091
120Prolonged neonatal jaundice (HP:0006579)2.01100484
121Fused cervical vertebrae (HP:0002949)2.00768605
122Spondylolisthesis (HP:0003302)2.00506713
123Gastrointestinal infarctions (HP:0005244)1.99204738
124Selective tooth agenesis (HP:0001592)1.98254293
125Hemoptysis (HP:0002105)1.97822980
126Pulmonary infiltrates (HP:0002113)1.96547878
127Hypoalphalipoproteinemia (HP:0003233)1.96419543
128Anhidrosis (HP:0000970)1.95720997
129Abnormality of iron homeostasis (HP:0011031)1.95193309
130Keratoconjunctivitis (HP:0001096)1.93821059
131Protrusio acetabuli (HP:0003179)1.93308877
132Cervical subluxation (HP:0003308)1.91954023
133Interstitial pulmonary disease (HP:0006530)1.91486470
134Inappropriate behavior (HP:0000719)1.90868388
135Nail dystrophy (HP:0008404)1.90742540
136Rickets (HP:0002748)1.86494811
137Blepharitis (HP:0000498)1.86461677
138Increased neuronal autofluorescent lipopigment (HP:0002074)1.85706125
139Acute myeloid leukemia (HP:0004808)1.85236409
140Enlarged epiphyses (HP:0010580)1.84844518
141Epistaxis (HP:0000421)1.84496450
142Submucous cleft hard palate (HP:0000176)1.83641684
143Recurrent skin infections (HP:0001581)1.83563535
144Peritonitis (HP:0002586)1.82924951
145Upper motor neuron abnormality (HP:0002127)1.82648183
146Abnormality of eosinophils (HP:0001879)1.82534410
147Mesangial abnormality (HP:0001966)1.82369050
148Abnormality of the basal ganglia (HP:0002134)1.82275311
149Conical tooth (HP:0000698)1.81921258
150J-shaped sella turcica (HP:0002680)1.80732628
151Purpura (HP:0000979)1.80558985
152Diminished motivation (HP:0000745)1.80462088
153Abnormality of the pleura (HP:0002103)1.79649747
154Pustule (HP:0200039)1.79330042
155Aortic valve stenosis (HP:0001650)1.77899621
156Nasal polyposis (HP:0100582)1.77681442
157Joint stiffness (HP:0001387)1.77505664
158Abnormality of the intrinsic pathway (HP:0010989)1.77402284
159Premature graying of hair (HP:0002216)1.76988137
160Vertigo (HP:0002321)1.76235016
161Anorexia (HP:0002039)1.76224683
162Glomerulopathy (HP:0100820)1.76163505
163Cellulitis (HP:0100658)1.76044521
164Short middle phalanx of the 5th finger (HP:0004220)1.74244894
165Vertebral compression fractures (HP:0002953)1.73716112
166Premature rupture of membranes (HP:0001788)1.72039832
167Malnutrition (HP:0004395)1.71744626
168Peripheral demyelination (HP:0011096)1.70141172
169Poikiloderma (HP:0001029)1.69995900
170Hypothermia (HP:0002045)1.69781712
171Achilles tendon contracture (HP:0001771)1.68029783
172Acne (HP:0001061)1.66295587
173Thoracic kyphosis (HP:0002942)1.64668788
174Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.63656012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.72982874
2GRK74.25425907
3PIM23.89509416
4RIPK13.48034470
5MOS3.12391527
6LATS22.61514132
7MAP3K142.59152071
8CDK82.47184421
9MKNK12.34720844
10NME22.29466929
11TBK12.25984993
12EIF2AK12.14906346
13IRAK42.11253971
14ERN12.10513614
15IRAK32.07004881
16NEK92.02316842
17MUSK2.01199054
18MAPKAPK51.90323889
19ERBB31.88133032
20RPS6KA41.81533040
21IKBKB1.81109805
22EIF2AK31.76066026
23TRPM71.75003921
24TYK21.73951835
25TAOK11.71058330
26MYLK1.70570317
27MAP3K121.70131158
28NUAK11.67951249
29KIT1.62077255
30BMPR1B1.60826684
31IKBKE1.60662360
32EPHA31.60208549
33TEC1.54951344
34MST41.54693624
35VRK11.50768784
36TGFBR11.48618996
37ZAK1.48291952
38MAP3K111.44885147
39PDGFRA1.43882370
40EIF2AK21.37764419
41PBK1.36943142
42CDC42BPA1.34566635
43PLK41.34029288
44ABL21.30563057
45SCYL21.29996556
46STK161.28655064
47PRPF4B1.27586721
48PIM11.26926260
49JAK31.22238590
50BTK1.21934201
51MAP3K51.20864659
52TXK1.16498593
53ILK1.16305267
54RPS6KB21.13872655
55TGFBR21.13828577
56CLK11.08575427
57MAP3K11.04666200
58BMPR21.04557291
59LRRK21.02049073
60CHUK0.98192898
61MATK0.97622562
62KDR0.97158287
63EEF2K0.90650928
64MAPKAPK30.87056241
65FRK0.86811961
66LATS10.86790856
67JAK10.81957012
68FGR0.81105228
69CSK0.80830009
70CSF1R0.79347240
71IRAK20.79161482
72BLK0.79085600
73TESK10.78202927
74CDK70.77857413
75LYN0.73932370
76TIE10.73785311
77TNIK0.73683995
78PKN20.71848581
79RAF10.70244632
80MAPK40.69358386
81DAPK30.68856319
82EPHB20.68506542
83STK100.68492355
84PIK3CG0.67901985
85TNK20.67091015
86PKN10.66894957
87FES0.66258549
88PAK40.65056399
89TLK10.64599207
90RPS6KA60.63739429
91RPS6KA50.63443288
92JAK20.63007993
93MARK30.62478088
94ATR0.62445453
95DYRK1B0.60178820
96GRK50.59572570
97ARAF0.59131296
98CDK60.58863530
99WEE10.58739134
100ABL10.58647748
101ICK0.57929943
102OBSCN0.57110552
103MAP3K130.55999360
104AURKB0.55826805
105SRPK10.54992019
106MAPKAPK20.54987318
107DYRK30.54276480
108SYK0.52419221
109MAP4K10.52141980
110RPS6KC10.52076937
111RPS6KL10.52076937
112BMX0.51358876
113YES10.51175553
114TTN0.50627570
115MAP3K30.49939398
116IRAK10.49904027
117AKT30.49253069
118PDGFRB0.48220613
119TAOK20.47169442
120MAP2K30.46927811
121ZAP700.46564654
122ADRBK20.46267999
123CAMKK20.45903095
124HCK0.45878972
125RIPK40.45867866
126PRKCD0.45829698
127BRAF0.44879183
128MKNK20.43224604
129NEK60.41710818
130INSRR0.41607657
131NLK0.40892569
132ACVR1B0.40416543
133GSK3A0.39526063
134TRIB30.39320341
135PAK20.39268193
136PDPK10.36487503
137PRKAA20.34923823
138CDK40.32284773
139HIPK20.31399037
140PAK10.30022421
141MAPK70.26536171
142MAP3K80.25286923
143PRKD20.24942553
144STK380.24355476
145RPS6KA20.21827187
146PLK20.21514490
147EGFR0.20967651
148TYRO30.20626996
149MAP2K60.19376446
150INSR0.18522663
151ROCK10.17518857
152PINK10.17311956

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.23861052
2Ribosome_Homo sapiens_hsa030102.91365174
3Graft-versus-host disease_Homo sapiens_hsa053322.53431817
4Leishmaniasis_Homo sapiens_hsa051402.39903603
5DNA replication_Homo sapiens_hsa030302.27555031
6Allograft rejection_Homo sapiens_hsa053302.16146306
7Legionellosis_Homo sapiens_hsa051342.13391769
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.13339136
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09198148
10Protein export_Homo sapiens_hsa030602.09192045
11Pertussis_Homo sapiens_hsa051332.08111907
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97976235
13Prion diseases_Homo sapiens_hsa050201.95985361
14Base excision repair_Homo sapiens_hsa034101.93445406
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.87821336
16Lysosome_Homo sapiens_hsa041421.80305759
17Complement and coagulation cascades_Homo sapiens_hsa046101.78017068
18Malaria_Homo sapiens_hsa051441.77942734
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76907279
20Herpes simplex infection_Homo sapiens_hsa051681.68791961
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68494486
22Salmonella infection_Homo sapiens_hsa051321.60981913
23Measles_Homo sapiens_hsa051621.60227767
24Type I diabetes mellitus_Homo sapiens_hsa049401.59866184
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.59672365
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.54349387
27TNF signaling pathway_Homo sapiens_hsa046681.51366646
28* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49697000
29Sulfur metabolism_Homo sapiens_hsa009201.49465936
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.48643572
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46190181
32Nucleotide excision repair_Homo sapiens_hsa034201.43624204
33Homologous recombination_Homo sapiens_hsa034401.31606087
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30556662
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.29740723
36Proteasome_Homo sapiens_hsa030501.25744666
37Hematopoietic cell lineage_Homo sapiens_hsa046401.23609021
38Toxoplasmosis_Homo sapiens_hsa051451.23405687
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21233158
40* Jak-STAT signaling pathway_Homo sapiens_hsa046301.21179874
41p53 signaling pathway_Homo sapiens_hsa041151.20379910
42Influenza A_Homo sapiens_hsa051641.20282429
43Rheumatoid arthritis_Homo sapiens_hsa053231.19571934
44Shigellosis_Homo sapiens_hsa051311.19022852
45Small cell lung cancer_Homo sapiens_hsa052221.18536754
46Apoptosis_Homo sapiens_hsa042101.16665284
47RNA polymerase_Homo sapiens_hsa030201.16463105
48Arachidonic acid metabolism_Homo sapiens_hsa005901.12686995
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12508246
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11310530
51Tuberculosis_Homo sapiens_hsa051521.10765094
52RNA degradation_Homo sapiens_hsa030181.10460749
53Autoimmune thyroid disease_Homo sapiens_hsa053201.10298353
54Asthma_Homo sapiens_hsa053101.06750086
55African trypanosomiasis_Homo sapiens_hsa051431.06715351
56Non-homologous end-joining_Homo sapiens_hsa034501.06625685
57Cell cycle_Homo sapiens_hsa041101.05965731
58Mismatch repair_Homo sapiens_hsa034301.05347498
59Hepatitis B_Homo sapiens_hsa051611.03107985
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02288511
61Antigen processing and presentation_Homo sapiens_hsa046121.02035927
62Basal transcription factors_Homo sapiens_hsa030220.98233875
63Viral myocarditis_Homo sapiens_hsa054160.97581832
64Thyroid cancer_Homo sapiens_hsa052160.96482122
65Amoebiasis_Homo sapiens_hsa051460.95811789
66PPAR signaling pathway_Homo sapiens_hsa033200.94756368
67Osteoclast differentiation_Homo sapiens_hsa043800.90581012
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89068833
69Tryptophan metabolism_Homo sapiens_hsa003800.88854863
70ECM-receptor interaction_Homo sapiens_hsa045120.88652925
71Phagosome_Homo sapiens_hsa041450.87842148
72Pyrimidine metabolism_Homo sapiens_hsa002400.87748893
73Spliceosome_Homo sapiens_hsa030400.87389696
74Type II diabetes mellitus_Homo sapiens_hsa049300.86882479
75Folate biosynthesis_Homo sapiens_hsa007900.86801799
76Systemic lupus erythematosus_Homo sapiens_hsa053220.86611276
77Acute myeloid leukemia_Homo sapiens_hsa052210.84152272
78Fatty acid biosynthesis_Homo sapiens_hsa000610.83150844
79Sphingolipid metabolism_Homo sapiens_hsa006000.81138980
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80714814
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78648832
82Platelet activation_Homo sapiens_hsa046110.78049450
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76700447
84Chronic myeloid leukemia_Homo sapiens_hsa052200.76392263
85Prolactin signaling pathway_Homo sapiens_hsa049170.74432790
86Chemokine signaling pathway_Homo sapiens_hsa040620.73988392
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.73467924
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71608258
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.69759296
90Galactose metabolism_Homo sapiens_hsa000520.69299959
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67577389
92N-Glycan biosynthesis_Homo sapiens_hsa005100.67174908
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63054551
94Other glycan degradation_Homo sapiens_hsa005110.60925226
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59510754
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58231411
97Phenylalanine metabolism_Homo sapiens_hsa003600.56381387
98Fatty acid degradation_Homo sapiens_hsa000710.55603107
99One carbon pool by folate_Homo sapiens_hsa006700.54177261
100Focal adhesion_Homo sapiens_hsa045100.53984287
101Hepatitis C_Homo sapiens_hsa051600.52800071
102Insulin resistance_Homo sapiens_hsa049310.52621108
103HTLV-I infection_Homo sapiens_hsa051660.51707830
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51632066
105Staphylococcus aureus infection_Homo sapiens_hsa051500.51016362
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50659984
107Primary immunodeficiency_Homo sapiens_hsa053400.50262409
108Viral carcinogenesis_Homo sapiens_hsa052030.49651710
109B cell receptor signaling pathway_Homo sapiens_hsa046620.49332881
110Glutathione metabolism_Homo sapiens_hsa004800.48951965
111Bladder cancer_Homo sapiens_hsa052190.48781996
112VEGF signaling pathway_Homo sapiens_hsa043700.48585978
113Fanconi anemia pathway_Homo sapiens_hsa034600.48185853
114Dorso-ventral axis formation_Homo sapiens_hsa043200.47045628
115Proteoglycans in cancer_Homo sapiens_hsa052050.45932358
116TGF-beta signaling pathway_Homo sapiens_hsa043500.45930282
117Pentose phosphate pathway_Homo sapiens_hsa000300.44991272
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44735423
119Mineral absorption_Homo sapiens_hsa049780.44696733
120Chemical carcinogenesis_Homo sapiens_hsa052040.43956951
121Purine metabolism_Homo sapiens_hsa002300.42692208
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40535456
123Epstein-Barr virus infection_Homo sapiens_hsa051690.39811068
124RNA transport_Homo sapiens_hsa030130.39235504
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38941189
126Fructose and mannose metabolism_Homo sapiens_hsa000510.37200190
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35548348
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.31929788
129Caffeine metabolism_Homo sapiens_hsa002320.31245743
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30332115
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28539493
132Dilated cardiomyopathy_Homo sapiens_hsa054140.28031629
133FoxO signaling pathway_Homo sapiens_hsa040680.23650489
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.22800422
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.22307205
136MicroRNAs in cancer_Homo sapiens_hsa052060.21260665
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20437069
138T cell receptor signaling pathway_Homo sapiens_hsa046600.17647959
139HIF-1 signaling pathway_Homo sapiens_hsa040660.17125273
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16336201
141MAPK signaling pathway_Homo sapiens_hsa040100.15902218

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